metaR Uritn
fast: false
reversible: true
product: MODEL1310110057#
name: uridine transport in nucleus
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110057#
is: SBO:0000185
kinetic law: MODEL1310110057#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_38418521_d130_4af4_8b02_2b3ffadd8602
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3283
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: P14060
name: HSD3B1

metaR CHATn
modifier: MODEL1310110057#
name: Choline O-acetyltransferase
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110057#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.6

metaR SPODMe
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.15.1.1
is described by: ECO:0000269
modifier: MODEL1310110057#
type: Reaction
is: SBO:0000176
name: superoxide dismutase, extracellular
product: MODEL1310110057#
reversible: false
fast: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (6649.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:12126755,PMID:3476950,PMID:9228011 NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110057#_04d6059e_970b_4264_b429_fde6b658aafd
is encoded by: hsa:1583
boundary condition: true
initial concentration: NaN
constant: false
name: CYP11A1
is: SBO:0000252
type: Species
is: G3XAD7
initial amount: NaN
has only substance units: false

metaM caro c
has only substance units: false
type: Species
is: CHEBI:17579
is: HMDB00561
is: SBO:0000247
constant: false
name: beta-carotene
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094

metaM mal L e
name: (S)-malate(2-)
is: CHEBI:15589
has only substance units: false
type: Species
is: HMDB00156
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
initial concentration: 1.0
initial amount: NaN

metaM pmtcrn x
name: L-palmitoylcarnitine
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00222
is: CHEBI:17490

metaR r1020
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
name: Postulated transport reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is described by: ECO:0000000
product: MODEL1310110057#
reversible: true
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_3fb49f3c_e429_426d_ae8c_94af0cd66493
has only substance units: false
is encoded by: hsa:AF116616
type: Species
initial concentration: NaN
constant: false
name: _AF116616_1_m
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_fe2cb80a_3ece_443f_ba64_03c3909b8ad6
is: P17516
initial amount: NaN
constant: false
name: AKR1C4
type: Species
is encoded by: hsa:1109
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM 2mb2coa c
is: SBO:0000247
is: HMDB02054
initial concentration: 1.0
constant: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
name: 2-methylcrotonoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110057#_654066a0_034d_41a5_8e89_221ea16934be
constant: false
initial concentration: NaN
is encoded by: hsa:AI971036
type: Species
is: SBO:0000252
name: _AI971036_1_m
has only substance units: false
initial amount: NaN
boundary condition: true

metaM ura e
constant: false
is: CHEBI:17568
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: uracil
type: Species
is: HMDB00300

metaM 5mthf e
has only substance units: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
type: Species
boundary condition: false
is: C00440
constant: false
initial concentration: 1.0
name: 5-Methyltetrahydrofolate
is: HMDB01396
is: SBO:0000247
initial amount: NaN
is: CHEBI:3729

metaR OCCOAtx
reactant: MODEL1310110057#
name: fatty acid intracellular transport
kinetic law: MODEL1310110057#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
fast: false

metaR PIPLC
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.1.4.11
modifier: MODEL1310110057#
name: phosphatidylinositol phospholipase C
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
reactant: MODEL1310110057#
reversible: false
kinetic law: MODEL1310110057#
type: Reaction
is described by: ECO:0000000

metaR XYLTD Dr
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:
name: xylitol dehydrogenase (D-xyulose-forming)
product: MODEL1310110057#
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_28b802a2_c427_4a00_9971_e6f7a54372d9
initial amount: NaN
is: SBO:0000252
name: PPT1
is encoded by: hsa:5538
boundary condition: true
is: Q6FGQ4
type: Species
constant: false
has only substance units: false
initial concentration: NaN

metaR r1569
product: MODEL1310110057#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction

metaR FAOXC121C101m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:1-->C10:1)m
type: Reaction

metaM pd3 c
type: Species
constant: false
is: HMDB06500
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
name: Previtamin D3
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM fe3 e
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB12943
is: CHEBI:29034
name: Fe3+
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110057#_ffe4dcb0_281e_4fae_95d4_cdc069ac61e8
initial concentration: NaN
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: Q16836
has only substance units: false
is encoded by: hsa:3033
name: HADH
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_b4f82a69_dc2c_49ac_abce_0141dda77084
is: P27144
initial amount: NaN
is encoded by: hsa:205
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
name: AK4
boundary condition: true

metaR C204CRNt
is: SBO:0000185
is described by: ECO:0000000
name: arachidonic acid transport into the mitochondria
kinetic law: MODEL1310110057#
reversible: false
reactant: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
type: Reaction
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_8f97f7b4_c4fe_4180_8f35_aeb89e46c397
type: Species
has only substance units: false
name: SLC13A4
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:26266
is: Q9UKG4
is: SBO:0000252

metaM ocdcea e
name: octadecenoate (n-C18:1)
is: C00712
notes: FORMULA: C18H33O2 CHARGE: -1
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB00207
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:0
boundary condition: false

metaR HDDACBP
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR CYSTA
is described by: ECO:0000304
fast: false
type: Reaction
reactant: MODEL1310110057#
name: cysteine transaminase
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_28c1f545_33ba_4358_b496_56cc3362e10c
is encoded by: hsa:55312
name: RFK
initial amount: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is: B2RDZ2
is: SBO:0000252

metaM uacgam c
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
initial concentration: 1.0
is: CHEBI:57705
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: SBO:0000247
type: Species
is: HMDB00290
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false

metaM glcur l
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00127
constant: false
is: CHEBI:15748
name: D-glucuronate
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaM HC01162 c
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:58376
type: Species
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate

http://identifiers.org/biomodels.db/MODEL1310110057#_96ee64f5_ba6c_4682_ae55_60a318251a9e
name: SLC35D2
type: Species
has only substance units: false
initial amount: NaN
is: Q76EJ3
initial concentration: NaN
boundary condition: true
is encoded by: hsa:11046
is: SBO:0000252
constant: false

metaR RE1522M
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000176
product: MODEL1310110057#
name: RE1522
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false

metaM hexde7coa x
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: 7-hexadecenoylcoa
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
constant: false
is: HMDB02288
is: SBO:0000247

metaR AHCYSte
type: Reaction
product: MODEL1310110057#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110057#
reversible: true
fast: false
kinetic law: MODEL1310110057#
name: Transport of S-adenosyl-L-homocysteine
is: SBO:0000185

metaM ksii core2 g
constant: false
boundary condition: false
initial concentration: 1.0
name: keratan sulfate II (core 2-linked)
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
has only substance units: false
is: CHEBI:17140
is: HMDB01644
type: Species
is: SBO:0000247
initial amount: NaN

metaR N2M2NMASNtly
is described by: ECO:0000000
fast: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
name: n2m2nmasn transport, extracellular to lysosome
is: SBO:0000185
type: Reaction
product: MODEL1310110057#
kinetic law: MODEL1310110057#

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

metaR GALASE15ly
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
name: beta-galactosidase, lysosomal
type: Reaction
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000

metaM octa c
boundary condition: false
is: HMDB00482
name: octanoate (n-C8:0)
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:25646
has only substance units: false
is: C06423
type: Species
notes: FORMULA: C8H15O2 CHARGE: -1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_f5ade01b_c901_4d43_9f77_0a0b19cb4609
is: B3KU59
boundary condition: true
is encoded by: hsa:6547
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
name: SLC8A3
type: Species

metaM 5mthf c
initial amount: NaN
has only substance units: false
constant: false
is: HMDB01396
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:3729
is: C00440
boundary condition: false
type: Species
name: 5-Methyltetrahydrofolate

metaR r1567
product: MODEL1310110057#
type: Reaction
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_41e406c3_d35e_4103_b8a3_8679c569f08d
is encoded by: hsa:2109
initial amount: NaN
name: ETFB
boundary condition: true
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is: P38117

metaR CLS hs
type: Reaction
is described by: ECO:0000000
product: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (54675.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10799718 NOTES:NJ
modifier: MODEL1310110057#
name: cardiolipin synthase (homo sapiens)
kinetic law: MODEL1310110057#
reversible: false

metaR AHCYStd
fast: false
name: diffusion of S-Adenosyl-L-homocysteine
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: true
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110057#

metaR RE3005M
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
modifier: MODEL1310110057#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
reactant: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110057#
name: RE3005
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_d6192e52_ca72_4c85_814f_6c440a9cc76d
name: ADH1A:ADH1B
is encoded by: hsa:124
initial concentration: NaN
is encoded by: hsa:125
has part: P00325
has part: P07327
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000297

metaR GALASE3ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
reversible: false
product: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
kinetic law: MODEL1310110057#
is: SBO:0000176
modifier: MODEL1310110057#

metaR DGK2m
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.8 Confidence Level: 2 AUTHORS: NOTES:Added EC- JLR IT
name: deoxyguanylate kinase (dGMP:dATP) (mitochondrial)
product: MODEL1310110057#
reversible: true
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_6ccca807_b3b1_445c_bbbe_3fcc41204b47
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
name: ACSS3
is: SBO:0000252
is: Q9H6R3
constant: false
initial amount: NaN
is encoded by: hsa:79611

metaM frdp x
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:175763
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
name: farnesyl pyrophosphate(3-)
initial concentration: 1.0
is: HMDB00961
has only substance units: false
constant: false

metaM ocdcea c
is: C00712
notes: FORMULA: C18H33O2 CHARGE: -1
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
constant: false
is: HMDB00207
is: CHEBI:0
boundary condition: false
initial amount: NaN
name: octadecenoate (n-C18:1)

metaM g3m8mpdol L r
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C1960H3228N20O770P20 CHARGE: -20
is: HMDB01342
is: C00459
type: Species
boundary condition: false
is: CHEBI:37568
has only substance units: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog

metaM glac c
name: D-glucurono-6,3-lactone
type: Species
is: HMDB06355
is: SBO:0000247
initial amount: NaN
is: CHEBI:18268
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
has only substance units: false

metaM 3mob e
initial amount: NaN
is: SBO:0000247
is: CHEBI:11851
boundary condition: false
type: Species
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
constant: false
has only substance units: false
name: 3-methyl-2-oxobutanoate
initial concentration: 1.0

metaR PI45P4P
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
product: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase

metaR FAOXC101m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

metaR r1568
reversible: true
reactant: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110057#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110057#
type: Reaction

metaM decdicoa c
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: decadienoylcoa
is: SBO:0000247
type: Species
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
is: HMDB01168

metaR FAOXC14C14OHm
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C14OH)m
type: Reaction

metaR LNELDCCPT2
fast: false
modifier: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
type: Reaction
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000000
name: carnitine transferase

metaM dhap e
constant: false
name: glycerone phosphate(2-)
is: CHEBI:57642
initial amount: NaN
is: SBO:0000247
is: HMDB01473
type: Species
initial concentration: 1.0
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110057#_metaR_FUCFUCFUCGALACGLC13GALACGLCGAL14ACGLCGALGLUSIDEte
type: Reaction
kinetic law: MODEL1310110057#
name: blood group intracellular transport
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is: SBO:0000185
product: MODEL1310110057#

metaM ksii core2 e
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
name: keratan sulfate II (core 2-linked)
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00211
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:17268

metaR r1565
product: MODEL1310110057#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110057#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110057#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_02c7bec4_c606_4812_92db_1d8347d26e8d
is encoded by: hsa:AI435857
type: Species
has only substance units: false
is: SBO:0000252
name: _AI435857_1_x
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM CE5869 e
type: Species
initial amount: NaN
is: HMDB02710
has only substance units: false
notes: FORMULA: C11H22N3O3 CHARGE: 1 INCHI: InChI=1/C11H21N3O3/c12-6-2-1-4-8(13)10(15)14-7-3-5-9(14)11(16)17/h8-9H,1-7,12-13H2,(H,16,17)/p+1/t8-,9-/m1/s1 EHMN_ABBREVIATION: CE5869
constant: false
name: lysyl-proline
is: CHEBI:27485
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaM m8masn r
boundary condition: false
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: C05876
notes: FORMULA: C70H117N2O55X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110057#_fe00474d_eec5_4707_8065_adea1f38a3b6
is: Q8IXW6
is encoded by: hsa:1809
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
type: Species
name: DPYSL3
initial concentration: NaN
initial amount: NaN

metaM octa e
is: SBO:0000247
type: Species
notes: FORMULA: C8H15O2 CHARGE: -1
constant: false
has only substance units: false
name: octanoate (n-C8:0)
initial amount: NaN
boundary condition: false
is: HMDB00482
initial concentration: 1.0
is: C06423
is: CHEBI:25646

http://identifiers.org/biomodels.db/MODEL1310110057#_d5435326_8519_4b75_90b9_213036fad1e3
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
name: OGDH
is: SBO:0000252
is: Q02218
is encoded by: hsa:4967

http://identifiers.org/biomodels.db/MODEL1310110057#_1111f39e_e2cd_461f_94a6_12e1236e227e
is: SBO:0000252
type: Species
name: PC
is: P11498
is encoded by: hsa:5091
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_d9ffb70b_92cd_40d7_87b7_67abe98b2ccb
is encoded by: hsa:3612
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is: B7Z6Q4
type: Species
name: IMPA1
is: SBO:0000252
has only substance units: false

metaR r1566
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110057#

metaR GLCt1r
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
modifier: MODEL1310110057#
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
is: SBO:0000185
product: MODEL1310110057#
reversible: true
is described by: ECO:0000269
type: Reaction
name: glucose transport (uniport)

metaR LNELDCCPT1
reversible: false
kinetic law: MODEL1310110057#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110057#
modifier: MODEL1310110057#
name: carnitine O-palmitoyltransferase
fast: false
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110057#_ad6e90c3_649b_41b7_87d5_a76d4e4551f5
initial amount: NaN
name: NDUFB5
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:4711
is: O43674
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_c9fce87c_963c_4946_83e4_5ebd737ef096
constant: false
is encoded by: hsa:54995
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
name: OXSM
type: Species
is: Q9NWU1
initial amount: NaN

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_7f5e6f21_e9d9_4dca_918f_f0a572cf4ed8
boundary condition: true
is encoded by: hsa:8612
is: SBO:0000252
is: E9PAY8
has only substance units: false
constant: false
initial concentration: NaN
name: PPAP2C
type: Species
initial amount: NaN

metaM uacgam g
initial amount: NaN
is: CHEBI:57705
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
boundary condition: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
type: Species
is: HMDB00290
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false

metaM asn L e
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
name: L-asparagine
type: Species
has only substance units: false
is: HMDB00168
initial concentration: 1.0
is: CHEBI:17196
initial amount: NaN

metaR CYSSNAT5tc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM 3mob c
name: 3-methyl-2-oxobutanoate
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
constant: false
is: SBO:0000247
is: CHEBI:11851
initial concentration: 1.0
boundary condition: false
is: HMDB00019

metaM 2decdicoa x
name: 2,7-decadienoylcoa
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/16019966

metaM dhap c
is: CHEBI:57642
constant: false
is: C00111
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: Dihydroxyacetone phosphate
type: Species
is: HMDB01473
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3411

metaR CMPSASn
kinetic law: MODEL1310110057#
reversible: false
reactant: MODEL1310110057#
fast: false
product: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.7.43
name: CMP sialic acid synthase, nuclear
modifier: MODEL1310110057#
is described by: ECO:0000304
type: Reaction

metaR M13N2Tg
is: SBO:0000176
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
fast: false
product: MODEL1310110057#
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
type: Reaction
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.101

metaM caro e
boundary condition: false
is: CHEBI:17579
constant: false
has only substance units: false
is: HMDB00561
is: SBO:0000247
initial amount: NaN
name: beta-carotene
initial concentration: 1.0
type: Species
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094

metaR DGCHOLte
name: bile acid intracellular transport
product: MODEL1310110057#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110057#
reversible: true
kinetic law: MODEL1310110057#
is: SBO:0000185
fast: false

metaM mal L c
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:15589
is: SBO:0000247
is: HMDB00156
type: Species
initial concentration: 1.0
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
name: (S)-malate(2-)
constant: false

metaR UMPK6n
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
name: UMP kinase (dCTP),nuclear
fast: false
reversible: true
product: MODEL1310110057#
is: SBO:0000176
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110057#_6e529ed5_dba5_4369_bbe9_a03e98c9ef23
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
name: HAO2
type: Species
is encoded by: hsa:51179
initial concentration: NaN

metaR FAOXC164C143x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)x
type: Reaction

metaM nadh r
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
is: HMDB01487
is: CHEBI:57945
initial amount: NaN
type: Species
is: SBO:0000247
name: NADH(2-)
has only substance units: false

metaM retfa c
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
boundary condition: false
initial amount: NaN
is: HMDB00305
type: Species
is: SBO:0000247
constant: false
is: CHEBI:50211
has only substance units: false
initial concentration: 1.0
name: fatty acid retinol

metaR RE0828E
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.4.3.22
name: RE0828
modifier: MODEL1310110057#
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
type: Reaction
fast: false

metaR BPNT
fast: false
reactant: MODEL1310110057#
product: MODEL1310110057#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.7
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
name: 3',5'-bisphosphate nucleotidase
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110057#_99b3a7a9_c783_471f_bdca_a4d587ee134a
initial amount: NaN
type: Species
is: Q9H903
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:441024
name: MTHFD2L
constant: false
is: SBO:0000252

metaR r1563
product: MODEL1310110057#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110057#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_metaR_FUCFUCFUCGALACGLC13GALACGLCGAL14ACGLCGALGLUSIDEtg
product: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#
name: blood group intracellular transport
fast: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is: SBO:0000185
reversible: true
type: Reaction

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_9e688a28_c326_49ae_a24e_1b8944ef9c8e
has only substance units: false
is encoded by: hsa:3098
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is: Q59FD4
boundary condition: true
name: HK1

metaR G14T19g
type: Reaction
kinetic law: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
product: MODEL1310110057#
modifier: MODEL1310110057#

metaM ivcoa c
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: Isovaleryl-CoA
has only substance units: false
is: HMDB01113
type: Species
notes: FORMULA: C26H40N7O17P3S CHARGE: -4

metaM ura c
is: HMDB00300
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
initial concentration: 1.0
type: Species
has only substance units: false
is: C00106
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:17568
initial amount: NaN
name: Uracil

metaM dadp c
constant: false
is: HMDB01508
is: SBO:0000247
boundary condition: false
name: dADP
initial concentration: 1.0
is: C00206
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:57667

http://identifiers.org/biomodels.db/MODEL1310110057#_790acb7b_8294_42a0_ab1b_14961e64f084
has only substance units: false
constant: false
initial amount: NaN
name: DECR1
boundary condition: true
initial concentration: NaN
type: Species
is: Q16698
is encoded by: hsa:1666
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_1c6ae699_2fd7_4619_a6fe_5fd375d9e119
type: Species
is: A8MU28
initial concentration: NaN
boundary condition: true
name: NAE1
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8883
initial amount: NaN
constant: false

metaR ADPCOAPTE
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of adipoyl coA for release into cytosol
type: Reaction

metaR TTDCPT1
reactant: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
fast: false
product: MODEL1310110057#
name: carnitine O-palmitoyltransferase
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1374.1) or (1375.2) or (126129.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110057#
is described by: ECO:0000269

metaR PMANM
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/5.4.2.2
type: Reaction
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/5.4.2.8
is described by: ECO:0000000
name: phosphomannomutase
reversible: true
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110057#_25a2d7b4_9df6_4f9f_bd32_2ff5afdd164b
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is: P37268
is encoded by: hsa:2222
type: Species
name: FDFT1

metaM q10 m
name: ubiquinone-10
is: HMDB01072
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:46245
is: SBO:0000247
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378

http://identifiers.org/biomodels.db/MODEL1310110057#_d94b3dc1_51e3_44b2_8064_938d40cf468b
constant: false
is encoded by: hsa:1376
name: CPT2
boundary condition: true
is: SBO:0000252
is: P23786
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN

metaM dhbpt c
name: 6,7-dihydrobiopterin
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
type: Species
is: HMDB00038
is: CHEBI:20680
initial amount: NaN
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268

metaR FAOXC185m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

metaM fe3 c
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: Fe3+
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB12943
notes: FORMULA: Fe CHARGE: 3

metaR r1564
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110057#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_fd288985_7b7e_4146_9ff3_8b3a29b147cc
is: SBO:0000252
name: COX7B
boundary condition: true
has only substance units: false
is: P24311
initial amount: NaN
type: Species
is encoded by: hsa:1349
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_2b0ac2c1_5537_4d00_b6fd_fd3a60246a7b
is encoded by: hsa:23236
boundary condition: true
is: Q9NQ66
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252
name: PLCB1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_449e254e_14c5_4cf0_b321_55e3c9e88610
initial concentration: NaN
constant: false
name: ADSSL1
is encoded by: hsa:122622
is: B3KTV4
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species

metaM asn L c
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
boundary condition: false
constant: false
name: L-asparagine
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00168
is: CHEBI:17196
initial amount: NaN

metaR 5ADTSTSTERONESte
is described by: ECO:0000000
name: sulfonated testosterone transport
type: Reaction
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
reactant: MODEL1310110057#
fast: false

metaR GCNTg
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.150
name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2651.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.150 Confidence Level: 4 AUTHORS: PMID:15161861,PMID:8449405 NOTES:NJ
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_6ad1e81e_fe4d_42da_bdf0_3d00b58b8e34
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:2348
initial amount: NaN
name: FOLR1
is: SBO:0000252
boundary condition: true

metaM btamp m
initial amount: NaN
constant: false
name: Biotinyl-5'-AMP
is: CHEBI:3110
is: SBO:0000247
is: HMDB04220
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
has only substance units: false

metaM ivcoa m
is: HMDB01113
type: Species
name: Isovaleryl-CoA
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
is: SBO:0000247
is: CHEBI:57345
boundary condition: false
initial amount: NaN
constant: false

metaR SPODMm
reactant: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: false
is: SBO:0000176
is described by: ECO:0000304
name: superoxide dismutase
fast: false
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.15.1.1

metaR r2201
product: MODEL1310110057#
fast: false
reversible: true
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110057#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is: SBO:0000185

metaM spmd e
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
initial concentration: 1.0
is: C00315
is: SBO:0000247
constant: false
has only substance units: false
name: Spermidine
initial amount: NaN
type: Species
is: CHEBI:57834
is: HMDB01257
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110057#_4c6a7be9_200d_4a2d_ac4b_bb13eade2e51
initial concentration: NaN
is encoded by: hsa:129642
type: Species
is: Q6ZWT7
has only substance units: false
boundary condition: true
name: MBOAT2
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_fd1f17ec_da33_41fa_b06a_bf5219dd6afd
name: HPD
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3242
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: B3KQ63

metaR RE3520E
reversible: true
is: SBO:0000176
fast: false
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.11.1.9
kinetic law: MODEL1310110057#
name: RE3520
modifier: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
type: Reaction
is described by: ECO:0000000

metaR FACOAL2042
reversible: true
kinetic law: MODEL1310110057#
is: SBO:0000176
reactant: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
name: fatty-acid--CoA ligase
type: Reaction
modifier: MODEL1310110057#

metaM retinal cis 13 r
type: Species
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: 13-cis-retinal
has only substance units: false
is: CHEBI:45487
is: HMDB06220
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_07c13735_a596_4b8b_9834_84d2a9d9f1ff
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is: Q08AH1
has only substance units: false
name: ACSM1
type: Species
is encoded by: hsa:116285
is: SBO:0000252

metaM dlnlcgcoa m
is: SBO:0000247
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
type: Species
is: CHEBI:27979
boundary condition: false
initial amount: NaN
constant: false
name: dihomo-gamma-linolenyl coenzyme A
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_3e18955d_9b0f_4d26_a5da_ddecd81b440a
has only substance units: false
boundary condition: true
is encoded by: hsa:9551
is: SBO:0000252
constant: false
type: Species
name: ATP5J2
initial concentration: NaN
is: F8W7V3
initial amount: NaN

metaM itacon m
constant: false
boundary condition: false
is: HMDB02092
is: CHEBI:17240
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
initial amount: NaN
type: Species
has only substance units: false
name: itaconate(2-)
initial concentration: 1.0
is: SBO:0000247

metaR MALTSULtm
fast: false
type: Reaction
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reversible: true
reactant: MODEL1310110057#
is: SBO:0000185
name: Malate:thiosulfate antiport, mitochondrial
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110057#_c428cd1f_49bf_48e4_a15d_2a1de87d83b2
is encoded by: hsa:AA614647
name: _AA614647_1_c
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaR FUT18g
is described by: ECO:0000269
fast: false
is: SBO:0000176
reactant: MODEL1310110057#
name: Galactoside 2-alpha-L-fucosyltransferase 1
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.69
reversible: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_1a678a4f_c421_440f_a5b0_af5917631036
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI345944
boundary condition: true
constant: false
has only substance units: false
name: _AI345944_1_m

metaR r2200
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000185
fast: false
reactant: MODEL1310110057#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is described by: ECO:0000000
modifier: MODEL1310110057#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM 4hoxpacd c
is: HMDB03767
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
is: CHEBI:15621
name: (4-hydroxyphenyl)acetaldehyde
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_eebc744d_c728_4078_8d25_30277b1f1ea0
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:AI091231
initial amount: NaN
name: _AI091231_1_c

metaR NDPK7n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reversible: true
fast: false
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
modifier: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110057#_10358fb6_f046_4670_8e24_f4fc8f99e442
is: B7Z9T9
type: Species
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5158
name: PDE6B
has only substance units: false

metaR B3GNT11g
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (10678.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
reactant: MODEL1310110057#
reversible: false
type: Reaction
is: SBO:0000176
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
modifier: MODEL1310110057#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110057#_ec665dd8_8107_45a6_8e4f_05269e568dde
type: Species
name: TPI1
initial concentration: NaN
constant: false
boundary condition: true
is: Q53HE2
initial amount: NaN
has only substance units: false
is encoded by: hsa:7167
is: SBO:0000252

metaR C4DCe
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of succinyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_af093c10_916e_46bd_9ea7_0f8d9345250b
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: PDXP
is encoded by: hsa:57026
initial amount: NaN
is: Q96GD0
has only substance units: false
constant: false

metaM datp c
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: C00131
is: CHEBI:61404
constant: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
name: dATP
is: HMDB01532

http://identifiers.org/biomodels.db/MODEL1310110057#_4fb6a11c_236b_4e33_9c33_939530b2e4e1
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
name: ACOT7
constant: false
is: SBO:0000252
is encoded by: hsa:11332
is: O00154

metaR r1454
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
kinetic law: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
product: MODEL1310110057#
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_eba1e6c9_75f3_4393_8f22_fa55907a93a1
is: SBO:0000252
name: ARSA
has only substance units: false
is encoded by: hsa:410
constant: false
type: Species
is: P15289
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM pmtcrn r
type: Species
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00222
name: L-palmitoylcarnitine
has only substance units: false
is: CHEBI:17490
initial concentration: 1.0

metaM spmd c
is: C00315
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: CHEBI:57834
is: HMDB01257
has only substance units: false
initial amount: NaN
name: Spermidine

http://identifiers.org/biomodels.db/MODEL1310110057#_b57a4b54_f027_4c9b_aec2_0f2bccde1519
is encoded by: hsa:229
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
name: ALDOB
type: Species
is: P05062

metaM CE5786 e
initial amount: NaN
is: CHEBI:27485
initial concentration: 1.0
is: SBO:0000247
name: kinetensin
is: HMDB02710
has only substance units: false
type: Species
constant: false
boundary condition: false
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786

http://identifiers.org/biomodels.db/MODEL1310110057#_d2d36cf7_ca21_4f3e_87c3_0a3c69af05b1
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
name: ST3GAL3
initial concentration: NaN
is encoded by: hsa:6487
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_09fb313b_bc1d_4b27_be69_e0f298a04f22
is encoded by: hsa:5053
initial amount: NaN
constant: false
name: PAH
type: Species
is: P00439
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR RETI1
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#
name: retinol isomerase (11-cis)
is: SBO:0000176
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_1b03a28f_d2fb_426f_a035_3f100d94c465
initial concentration: NaN
is: H0YMZ7
has only substance units: false
name: PDE8A
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:5151
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_1fc0271b_76fa_4e98_b90d_144b6e04bffb
has part: P22392
is: SBO:0000297
has part: P15531
boundary condition: true
is encoded by: hsa:4831
initial amount: NaN
name: NME1:NME2
type: Species
is encoded by: hsa:4830
initial concentration: NaN
constant: false
has only substance units: false

metaM c10dc x
type: Species
has only substance units: false
notes: FORMULA: C17H30NO6 CHARGE: -1
is: HMDB00651
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
name: sebacoyl carnitine

metaM gacpail hs r
boundary condition: false
type: Species
is: C00092
constant: false
is: HMDB01401
is: SBO:0000247
name: glucosaminyl-acylphosphatidylinositol
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
is: CHEBI:61548
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_52f6af16_394c_4874_9db8_68388523f9ad
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
has only substance units: false
constant: false
has part: Q5VYT2
boundary condition: true
is encoded by: hsa:4712
initial amount: NaN
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:4731
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_53279c35_ebf6_487c_a3b6_b84bca0bbd8b
is: Q16881
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:7296
has only substance units: false
initial concentration: NaN
constant: false
name: TXNRD1

metaR r2202
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
modifier: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#

metaR GAO1g
name: Ganglioside O-acetylation
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
is described by: ECO:0000269
modifier: MODEL1310110057#
reactant: MODEL1310110057#
reversible: false
kinetic law: MODEL1310110057#
fast: false
product: MODEL1310110057#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110057#_8a651329_51a9_4972_adae_1134d637515b
boundary condition: true
has only substance units: false
is: Q99685
constant: false
is encoded by: hsa:11343
initial concentration: NaN
is: SBO:0000252
type: Species
name: MGLL
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_0a90f8d8_6949_464a_b9d9_ed40f45990e1
name: SLC3A2:SLC7A6
has only substance units: false
is encoded by: hsa:9057
type: Species
is: SBO:0000297
constant: false
initial amount: NaN
boundary condition: true
has part: Q92536
initial concentration: NaN

metaR NACHEXA12ly
type: Reaction
reactant: MODEL1310110057#
name: beta-N-acetylhexosaminidase A, lysosomal
is: SBO:0000176
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
is described by: ECO:0000000

metaM c10crn e
name: decanoyl carnitine
constant: false
notes: FORMULA: C17H33NO4 CHARGE: 0
type: Species
initial concentration: 1.0
is: HMDB00651
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110057#_c6ad5793_c89f_4d60_b880_9243810a0ac8
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5152
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: PDE9A

metaM dudp n
name: dUDP(3-)
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: CHEBI:60471
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: HMDB01000

metaM 3mob m
type: Species
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
initial concentration: 1.0
name: 3-methyl-2-oxobutanoate
boundary condition: false
is: HMDB00019
is: SBO:0000247
is: CHEBI:11851
constant: false
has only substance units: false
initial amount: NaN

metaM nadh x
is: CHEBI:57945
is: HMDB01487
initial amount: NaN
name: Nicotinamide adenine dinucleotide - reduced
is: http://identifiers.org/pubchem.compound/3306
is: C00004
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
boundary condition: false

metaR r1682
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110057#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110057#
modifier: MODEL1310110057#
reversible: false
type: Reaction
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_9b357f2c_da9d_4a70_b81d_3e446bf44e43
constant: false
is encoded by: hsa:4724
initial amount: NaN
type: Species
name: NDUFS4
initial concentration: NaN
boundary condition: true
is: O43181
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_97827ec4_d72d_4025_9e40_c8b954de5a63
has only substance units: false
initial amount: NaN
is: Q96EK6
boundary condition: true
type: Species
initial concentration: NaN
name: GNPNAT1
is encoded by: hsa:64841
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_43f6d9a6_a507_412a_aef1_df41dfee85eb
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:6817
constant: false
initial concentration: NaN
type: Species
name: SULT1A1

http://identifiers.org/biomodels.db/MODEL1310110057#_6af91ba0_fb33_4870_a035_c52ee4b49aba
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
name: ALDH3A1
is encoded by: hsa:218
type: Species
is: SBO:0000252
initial concentration: NaN
is: P30838

http://identifiers.org/biomodels.db/MODEL1310110057#_caa2f8a0_3865_4196_9fab_52e952e18d1e
name: PIGK:PIGU:PIGT:GPAA1:PIGS
type: Species
is encoded by: hsa:10026
has part: O43292
has only substance units: false
has part: Q9H490
is encoded by: hsa:8733
has part: Q969N2
constant: false
is: SBO:0000297
is encoded by: hsa:51604
boundary condition: true
initial amount: NaN
has part: Q8NBL9
is encoded by: hsa:94005
has part: Q92643
is encoded by: hsa:128869
initial concentration: NaN

metaM glcur r
initial concentration: 1.0
is: SBO:0000247
is: HMDB00127
boundary condition: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: CHEBI:15748
type: Species
name: D-glucuronate
initial amount: NaN
constant: false
has only substance units: false

metaM txa2 r
type: Species
is: CHEBI:57445
has only substance units: false
is: SBO:0000247
name: thromboxane A2(1-)
is: HMDB01452
constant: false
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
initial amount: NaN
initial concentration: 1.0

metaM xoldiolone r
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
initial amount: NaN
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:28477
constant: false
is: HMDB02197

metaM mi14p c
has only substance units: false
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
is: HMDB00968
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:58282
type: Species
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_f18a8cde_1401_4348_9080_f2313e461004
has only substance units: false
is encoded by: hsa:8398
initial concentration: NaN
type: Species
is: A8K460
name: PLA2G6
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaM T4hcinnm m
is: SBO:0000247
is: HMDB02035
is: CHEBI:12876
name: trans-4-coumarate
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H7O3 CHARGE: -1 INCHI: InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/p-1/b6-3+ EHMN_ABBREVIATION: C00811
initial concentration: 1.0
constant: false
type: Species

metaM dudp m
initial amount: NaN
is: SBO:0000247
is: HMDB01000
constant: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial concentration: 1.0
type: Species
boundary condition: false
name: dUDP(3-)
has only substance units: false
is: CHEBI:60471

metaM acmana c
type: Species
name: N-acetyl-D-mannosamine
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
boundary condition: false
has only substance units: false
is: HMDB01129
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17122

metaR NACHEXA9ly
type: Reaction
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110057#
reversible: false
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110057#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is: SBO:0000176
kinetic law: MODEL1310110057#

metaM mev R c
type: Species
is: HMDB00227
is: SBO:0000247
name: (R)-mevalonate
is: CHEBI:36464
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
constant: false
initial concentration: 1.0

metaM gthox c
initial concentration: 1.0
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: C00127
initial amount: NaN
boundary condition: false
is: HMDB03337
constant: false
has only substance units: false
type: Species
name: Oxidized glutathione
is: CHEBI:58297
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_ad695e13_69db_4b1c_8db9_9decad37e372
has only substance units: false
is encoded by: hsa:85365
is: SBO:0000252
is: Q9H553
initial concentration: NaN
type: Species
name: ALG2
boundary condition: true
initial amount: NaN
constant: false

metaM glac r
is: CHEBI:18268
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: D-glucurono-6,3-lactone
constant: false
initial concentration: 1.0
is: HMDB06355
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
type: Species
has only substance units: false

metaR THFtm
is described by: ECO:0000000
product: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reversible: true
kinetic law: MODEL1310110057#
is: SBO:0000185

metaR EX tetdec2crn
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_6680e057_d49e_49cb_8b55_c38036c56ffb
initial concentration: NaN
has only substance units: false
name: PIGX
boundary condition: true
is encoded by: hsa:54965
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is: Q8TBF5

metaR DMHPTCRNCPT2
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:made reversible since Keq ~ 0.6. dmhptcoa is a special case because its biochemical fate has not be elucidated. NJ
product: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110057#
is described by: ECO:0000000
fast: false
name: 2,6 dimethylheptanoly CoA carnitine transferase

metaR DNDPt35m
is described by: ECO:0000269
reactant: MODEL1310110057#
is: SBO:0000185
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reversible: false
modifier: MODEL1310110057#
name: dGDP transport via dADP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
type: Reaction

metaM core4 g
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C24H40N3O15X CHARGE: 0
has only substance units: false
is: CHEBI:16478
type: Species
name: Core 4

metaM 12ppd S c
is: HMDB06213
is: SBO:0000247
boundary condition: false
is: CHEBI:29002
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: (S)-propane-1,2-diol
type: Species
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1

metaR EX tststerones LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: testosterone sulfate exchange
type: Reaction

metaM ksi deg33 l
is: HMDB00143
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
boundary condition: false
is: SBO:0000247
constant: false
name: keratan sulfate I, degradation product 33
initial amount: NaN
is: CHEBI:12936
has only substance units: false
type: Species
initial concentration: 1.0

metaR EX c51crn
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

metaM 3dodtricoa m
is: HMDB11123
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: SBO:0000247
name: 3,6,9-dodecatrienoylcoa
is: C05279
initial concentration: 1.0
has only substance units: false
type: Species

metaM c10crn c
notes: FORMULA: C17H33NO4 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: decanoyl carnitine
is: HMDB00651
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaM cspg c l
has only substance units: false
is: HMDB02183
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
initial amount: NaN
boundary condition: false
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan
initial concentration: 1.0
is: CHEBI:36005

http://identifiers.org/biomodels.db/MODEL1310110057#_86bf4d71_0f2b_403d_80c4_15551eb4fa9d
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q8WVQ1
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:124583
type: Species
name: CANT1

metaM lneldccoa m
initial concentration: 1.0
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/5462164
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
name: linoelaidyl coenzyme A
type: Species
is: HMDB01064
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_5259edb3_5ea3_417b_8cd2_e01d24ff3ab6
initial concentration: NaN
is: Q9NPC4
is encoded by: hsa:53947
name: A4GALT
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true

metaR r1459
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000185
type: Reaction
fast: false
reversible: true
product: MODEL1310110057#
is described by: ECO:0000000
name: Transport reaction
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#

metaM ksii core2 l
initial concentration: 1.0
constant: false
is: HMDB01644
name: keratan sulfate II (core 2-linked)
is: SBO:0000247
boundary condition: false
is: CHEBI:17140
has only substance units: false
type: Species
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
initial amount: NaN

metaR DURIt
is described by: ECO:0000000
name: deoxyuridine transport via diffusion
is: SBO:0000185
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
type: Reaction

metaM thmmp m
initial amount: NaN
type: Species
notes: FORMULA: C12H16N4O4PS CHARGE: -1 INCHI: InChI=1S/C12H17N4O4PS/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19)/p-1 EHMN_ABBREVIATION: C01081
is: HMDB02666
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
name: thiamine(1+) monophosphate(2-)
is: CHEBI:37575
has only substance units: false

metaR r0074
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
fast: false
modifier: MODEL1310110057#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.1
product: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_c61658a1_7eba_4383_8939_8121a6820b94
name: NDUFA5
is: Q16718
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4698
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaR GCHOLAt2
is: SBO:0000185
modifier: MODEL1310110057#
type: Reaction
reversible: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (6554.1) or (6555.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12851823,PMID:7592981,PMID:8132774,PMID:9109432 NOTES:electrogenic uptake NJ
product: MODEL1310110057#
name: glycocholate transport via sodium cotransport
reactant: MODEL1310110057#
fast: false
is described by: ECO:0000269

metaR ALAGLNexR
kinetic law: MODEL1310110057#
product: MODEL1310110057#
name: L-alanine/glutamine reversible exchange
type: Reaction
is: SBO:0000185
reactant: MODEL1310110057#
reversible: true
modifier: MODEL1310110057#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false

metaM galgalthcrm hs g
type: Species
initial amount: NaN
is: CHEBI:26174
constant: false
initial concentration: 1.0
name: Gal-Gal-Gal-Gal-Glc-Cer
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C48H86NO27FULLRCO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110057#_4c6be74d_7c85_4de0_b2a7_508b465cf05a
has only substance units: false
is encoded by: hsa:54872
initial concentration: NaN
is: SBO:0000297
initial amount: NaN
constant: false
has part: Q8NCI4
boundary condition: true
type: Species
name: PIGF:PIGG

metaR FAOXC101C8m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

metaR HSD11B2r
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.1.1.146
type: Reaction
product: MODEL1310110057#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3291.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110057#
name: 11-beta-hydroxysteroid dehydrogenase type 2
reversible: true

metaR DRPA
is: SBO:0000176
fast: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
name: deoxyribose-phosphate aldolase
reversible: false
is described by: ECO:0000000
product: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction

metaM CE4792 m
is: CHEBI:57923
has only substance units: false
initial concentration: 1.0
name: 3-oxo-cis-8-tetradecenoyl-CoA
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
type: Species

metaR FAOXC225x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)x
type: Reaction

metaM q10 c
initial concentration: 1.0
is: CHEBI:46245
is: SBO:0000247
name: ubiquinone-10
initial amount: NaN
constant: false
type: Species
has only substance units: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
boundary condition: false
is: HMDB01072

metaM 4ppan c
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
name: D-4'-Phosphopantothenate
is: CHEBI:10986
boundary condition: false
constant: false
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB01016
initial concentration: 1.0
initial amount: NaN
is: C03492

http://identifiers.org/biomodels.db/MODEL1310110057#_f015371f_eaa9_48de_a1fe_06ca49b2e780
is encoded by: hsa:4047
boundary condition: true
is: E9PEI9
name: LSS
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR MMCDm
is described by: ECO:0000212
kinetic law: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES:JLR mitochondrial isoform - NCD
reactant: MODEL1310110057#
name: Methylmalonyl-CoA decarboxylase, mitochondrial
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/4.1.1.9
fast: false
type: Reaction
modifier: MODEL1310110057#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110057#_b4b3d88c_1a81_4c8c_b32c_aeb0b3dd1f37
is: SBO:0000252
name: ACHE
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:43
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_002f1f5a_b45d_4cb4_915b_928c589a39fc
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:23236
initial amount: NaN
is: SBO:0000252
name: PLCB1
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_eb4267d9_4f08_48bc_a1c4_ce21f19557e6
constant: false
name: MECR
is: SBO:0000252
is encoded by: hsa:51102
boundary condition: true
is: Q9BV79
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN

metaM cl c
type: Species
constant: false
name: Chloride
initial concentration: 1.0
notes: FORMULA: Cl CHARGE: -1
is: HMDB00492
is: C00115
initial amount: NaN
is: CHEBI:3966
boundary condition: false
has only substance units: false
is: SBO:0000247

metaM lneldccoa c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
type: Species
is: HMDB06521
is: SBO:0000247
name: linoelaidyl coenzyme A
constant: false
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/9543677

metaR MMTSADm
reversible: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1527093 NOTES:MM. biochemical activity measured in rat, sequence similarity found in human
kinetic law: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: malonate-semialdehyde dehydrogenase (acetylating), mitochondrial
fast: false
reactant: MODEL1310110057#

metaR C142OHe
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:2-OH
type: Reaction

metaM hdd2crn c
initial amount: NaN
is: HMDB06317
boundary condition: false
has only substance units: false
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: trans-Hexadec-2-enoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110057#_b79b666c_0406_4c5f_b5fd_2f7628cb2a7e
initial amount: NaN
has only substance units: false
is: O95861
initial concentration: NaN
name: BPNT1
boundary condition: true
type: Species
constant: false
is encoded by: hsa:10380
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_e9268d7e_e983_46ce_a3dd_6b46c8ad0cc2
name: PLCD4
boundary condition: true
constant: false
initial amount: NaN
is: Q9BRC7
is encoded by: hsa:84812
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_47b6c9dd_47e1_4dbb_96f4_ea7466a6d44c
has only substance units: false
type: Species
name: PISD
constant: false
initial amount: NaN
boundary condition: true
is: Q9UG56
is encoded by: hsa:23761
initial concentration: NaN
is: SBO:0000252

metaM CE5854 e
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
name: gama-CEHC-glucuronide
constant: false
initial amount: NaN
is: HMDB02710
is: SBO:0000247
is: CHEBI:27485

metaR FAOXC160
reversible: false
reactant: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
name: Beta oxidation of long chain fatty acid
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110057#_b3963000_9528_49de_b442_d76c4b598a4a
is encoded by: hsa:50
is: Q99798
initial amount: NaN
name: ACO2
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false

metaM ksi pre31 g
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
is: SBO:0000247
is: HMDB00175
type: Species
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 31
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:58053
is: C00130
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_6633e614_61be_452b_9115_2382dd9351c3
constant: false
name: ATP5G2
is encoded by: hsa:517
is: Q06055
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaM ksi pre16 g
constant: false
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
is: C00130
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 16
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00175

metaM melatn c
name: melatonin
is: CHEBI:16796
notes: FORMULA: C13H16N2O2 CHARGE: 0 INCHI: InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C01598
initial amount: NaN
is: HMDB01389
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species

metaR EX ptdca LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentadecanoate exchange
type: Reaction

metaR COQ7m
type: Reaction
fast: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
modifier: MODEL1310110057#
name: Ubiquinone biosynthesis COQ7
notes: GENE_ASSOCIATION: (10229.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.14.13.- IT
is described by: ECO:0000269
product: MODEL1310110057#
reversible: false
is: SBO:0000176

metaM ksi pre32 g
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
constant: false
is: CHEBI:28067
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 32

http://identifiers.org/biomodels.db/MODEL1310110057#_f59a6d01_f71f_4168_903d_5be4ff8c4a21
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is: P30838
initial amount: NaN
has only substance units: false
name: ALDH3A1
is encoded by: hsa:218
type: Species

metaR PCHOLP hs
reversible: false
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
product: MODEL1310110057#
reactant: MODEL1310110057#
name: choline phosphatase
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.1.4.4
is: SBO:0000176
modifier: MODEL1310110057#
type: Reaction

metaR FAOXC161C141x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C16:1-->C14:1)x
type: Reaction

metaM 3dodtricoa x
is: HMDB11123
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: C05279
name: 3,6,9-dodecatrienoylcoa
has only substance units: false
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN

metaR GLUt2m
notes: GENE_ASSOCIATION: (83733.1) or (8604.1) or (79751.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
product: MODEL1310110057#
is described by: ECO:0000269
fast: false
is: SBO:0000185
modifier: MODEL1310110057#
reversible: true
type: Reaction
name: L-glutamate reversible transport via proton symport, mitochondrial
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#

metaM 3ivcoa m
is: C05998
initial concentration: 1.0
name: 3-hydroxyisovalerylcoa
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/11966188
has only substance units: false
is: HMDB06870
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110057#_54dd1954_2199_4966_a01e_16965f3d0a73
boundary condition: true
name: GPD1
is encoded by: hsa:2819
has only substance units: false
is: SBO:0000252
constant: false
is: F8W1L5
initial amount: NaN
type: Species
initial concentration: NaN

metaR HMGLm
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
is: SBO:0000176
product: MODEL1310110057#
reactant: MODEL1310110057#
name: hydroxymethylglutaryl-CoA lyase
kinetic law: MODEL1310110057#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/4.1.3.4
modifier: MODEL1310110057#
is described by: ECO:0000134
type: Reaction

metaM 2mp2coa m
boundary condition: false
is: HMDB01011
constant: false
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:27754
initial concentration: 1.0
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
name: 2-Methylprop-2-enoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110057#_953e23ce_cf4b_42fb_af92_49a2dbd90385
is: P51570
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: GALK1
is encoded by: hsa:2584
initial concentration: NaN
has only substance units: false
constant: false

metaR ASCBt
kinetic law: MODEL1310110057#
fast: false
name: L-ascorbate transport via facilitated diffusion
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
product: MODEL1310110057#
reactant: MODEL1310110057#
reversible: true

metaR DAGK hs
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
name: Diacylglycerol phosphate kinase (homo sapiens)
product: MODEL1310110057#
modifier: MODEL1310110057#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110057#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.107
reactant: MODEL1310110057#
reversible: true

metaM succoa c
constant: false
initial concentration: 1.0
name: Succinyl-CoA
is: HMDB01022
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
initial amount: NaN
boundary condition: false

metaR GLCNACT L
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
reversible: false
product: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (liver)
is described by: ECO:0000000
is: SBO:0000176

metaR FAOXC164C143m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)m
type: Reaction

metaR GCC2cm
is version of: http://identifiers.org/ec-code/2.1.2.10
type: Reaction
product: MODEL1310110057#
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/1.8.1.4
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
fast: false
kinetic law: MODEL1310110057#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110057#
is: SBO:0000176
name: glycine-cleavage complex (lipoamide), mitochondrial

metaM mi14p n
boundary condition: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
is: HMDB00968
initial concentration: 1.0
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:58282
has only substance units: false

metaM btamp c
boundary condition: false
is: SBO:0000247
is: HMDB04220
initial amount: NaN
name: Biotinyl-5'-AMP
is: CHEBI:3110
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921

metaR GALtly
product: MODEL1310110057#
type: Reaction
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
fast: false
is described by: ECO:0000000
reactant: MODEL1310110057#
name: galactose efflux from lysosome

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_2d21d94b_9f57_4ac1_beb0_421e75a7489d
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ATP5E
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: P56381
is encoded by: hsa:514

metaM c4dc e
name: succinyl carnitine
constant: false
notes: FORMULA: C11H18NO6 CHARGE: -1
is: C02862
is: HMDB02013
initial concentration: 1.0
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/213144
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM ksii core2 deg1 l
is: HMDB00868
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
boundary condition: false
has only substance units: false
is: CHEBI:57737
type: Species
name: keratan sulfate II (core 2-linked), degradation product 1

metaM cl e
is: HMDB00492
notes: FORMULA: Cl CHARGE: -1
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:3966
constant: false
name: Chloride
is: C00115

http://identifiers.org/biomodels.db/MODEL1310110057#_7963ea14_9cf3_452d_a610_09dd29e26238
initial concentration: NaN
is: SBO:0000252
name: CPT1B
is encoded by: hsa:1375
type: Species
initial amount: NaN
is: Q92523
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_29f54d37_edb8_458c_832d_3ee780b9a164
name: NT5C2
is: SBO:0000252
type: Species
boundary condition: true
constant: false
is encoded by: hsa:22978
initial concentration: NaN
has only substance units: false
is: P49902
initial amount: NaN

metaM dgtp m
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:16497
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: C00286
has only substance units: false
is: HMDB01440
name: dGTP
type: Species
initial amount: NaN
is: SBO:0000247

metaR FAS160COA
kinetic law: MODEL1310110057#
product: MODEL1310110057#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.3.1.85
name: fatty-acyl-CoA synthase (n-C16:0CoA)
is: SBO:0000176
reversible: false
modifier: MODEL1310110057#

metaR DECDICRNe
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of decadienoyl carnitine into the extra cellular space
type: Reaction

metaR FAOXTC122TC101m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C12:2-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_f7006924_7f81_4961_8e6f_f6ff96b731de
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:79646
has only substance units: false
is: Q9H999
name: PANK3
constant: false

metaM c51crn c
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C12H21NO4 CHARGE: 0
constant: false
initial concentration: 1.0
initial amount: NaN
name: tiglyl carnitine
is: HMDB02366
type: Species

metaR ADK1
is: SBO:0000176
name: adenylate kinase
modifier: MODEL1310110057#
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
kinetic law: MODEL1310110057#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110057#

metaM acetone c
constant: false
type: Species
boundary condition: false
is: SBO:0000247
name: acetone
has only substance units: false
is: CHEBI:15347
initial concentration: 1.0
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
initial amount: NaN
is: HMDB01659

metaM mthgxl c
initial concentration: 1.0
is: CHEBI:17158
constant: false
has only substance units: false
initial amount: NaN
name: methylglyoxal
is: HMDB01167
is: SBO:0000247
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
boundary condition: false
type: Species

metaM thmmp c
is: CHEBI:37575
has only substance units: false
is: HMDB02666
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
name: Thiamin monophosphate
constant: false
is: C01081
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
boundary condition: false

metaM ocdcea r
type: Species
name: octadecenoate (n-C18:1)
notes: FORMULA: C18H33O2 CHARGE: -1
is: C00712
is: SBO:0000247
has only substance units: false
is: HMDB00207
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:0
initial concentration: 1.0

metaR FAOXC11C9m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C11-->C9)m
type: Reaction

metaR PDE1
is version of: http://identifiers.org/ec-code/3.1.4.17
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.1.4.35
name: 3',5'-cyclic-nucleotide phosphodiesterase
product: MODEL1310110057#
reversible: false
reactant: MODEL1310110057#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110057#_d15ec3ea_c870_4c8a_8b83_d91653c7724c
is encoded by: hsa:55349
initial concentration: NaN
is: SBO:0000252
name: CHDH
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: Q8NE62
type: Species

metaM icit m
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: HMDB00193
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
is: C00311
initial amount: NaN
constant: false
name: Isocitrate
initial concentration: 1.0
is: CHEBI:16087

metaR r0295
modifier: MODEL1310110057#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
is: SBO:0000176
product: MODEL1310110057#
type: Reaction
name: glycine synthase Nitrogen metabolism EC:2.1.2.10

metaR r1464
kinetic law: MODEL1310110057#
reversible: true
reactant: MODEL1310110057#
name: Active transport
product: MODEL1310110057#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:

metaR 5HOXINDACTO2OX
reversible: false
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.2.3.1
product: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.3.1 Confidence Level: 2 AUTHORS: PMID:11306106 NOTES:SAB questionable--balanced, but h2o2 production is based on an obscure comment in entrez
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is described by: ECO:0000304
name: 5-Hydroxyindoleacetaldehyde:oxygen oxidoreductase

http://identifiers.org/biomodels.db/MODEL1310110057#_2bc5423a_1ed3_4335_941e_0afa6e8e50c1
constant: false
boundary condition: true
initial amount: NaN
type: Species
name: GLO1
is: Q04760
initial concentration: NaN
is encoded by: hsa:2739
has only substance units: false
is: SBO:0000252

metaM CE4876 r
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
has only substance units: false
is: CHEBI:57923
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
name: delta12-Prostaglandin J2
initial concentration: 1.0

metaR r1678
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110057#
is described by: ECO:0000000
product: MODEL1310110057#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110057#
fast: false
is: SBO:0000185
reversible: false
type: Reaction
reactant: MODEL1310110057#

metaM ser L e
has only substance units: false
is: HMDB00187
boundary condition: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: CHEBI:17115
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
name: L-serine

metaR NORANMT
modifier: MODEL1310110057#
fast: false
product: MODEL1310110057#
is described by: ECO:0000269
name: noradrenaline N-methyltransferase
type: Reaction
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5409.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.1.1.28 Confidence Level: 4 AUTHORS: NOTES:SAB
is version of: http://identifiers.org/ec-code/2.1.1.28

metaR r1019
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
kinetic law: MODEL1310110057#
is described by: ECO:0000000
name: Postulated transport reaction
reversible: true
reactant: MODEL1310110057#
is: SBO:0000185
product: MODEL1310110057#
fast: false

metaR ILETAm
kinetic law: MODEL1310110057#
is: SBO:0000176
fast: false
name: isoleucine transaminase, mitochondrial
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
type: Reaction
is described by: ECO:0000269
product: MODEL1310110057#
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
modifier: MODEL1310110057#
reactant: MODEL1310110057#

metaR ACNACNGALGBSIDEte
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000000
reactant: MODEL1310110057#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
name: acnacngalgbside hs transport
fast: false
type: Reaction

metaR MI14P4P
reversible: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110057#
is: SBO:0000176
name: inositol-1,4-bisphosphate 4-phosphatase

metaM acetone e
type: Species
is: SBO:0000247
boundary condition: false
name: acetone
is: CHEBI:15347
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB01659
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_0a4e1207_3976_405c_98a4_69d850fa968e
boundary condition: true
initial amount: NaN
is encoded by: hsa:MBOAT5
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
name: _MBOAT5_1_c

http://identifiers.org/biomodels.db/MODEL1310110057#_5870cea5_6b9c_4134_87fa_a186d78ad545
is encoded by: hsa:6487
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: ST3GAL3
boundary condition: true
initial concentration: NaN

metaR EX 3mlda LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-Methylimidazoleacetic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_50af1473_b813_48f8_8df2_c0e04b7a9905
boundary condition: true
initial amount: NaN
constant: false
name: _R51273_1_c
is encoded by: hsa:R51273
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaR ADK3
product: MODEL1310110057#
type: Reaction
reversible: true
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
name: adentylate kinase (GTP)
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176

metaM nadh c
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: C00004
is: http://identifiers.org/pubchem.compound/3306
is: CHEBI:57945
initial amount: NaN
constant: false
name: Nicotinamide adenine dinucleotide - reduced
initial concentration: 1.0
is: HMDB01487

metaR r0899
type: Reaction
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
name: Amino acid transporter ATB0+ Facilitated diffusion
fast: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true

metaR SERPT
is: SBO:0000176
product: MODEL1310110057#
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction
fast: false
is described by: ECO:0000269
modifier: MODEL1310110057#
reversible: false
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.50
name: serine C-palmitoyltransferase

metaM sebacid c
is: SBO:0000247
has only substance units: false
is: HMDB00792
name: sebacicacid
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: C08277
initial amount: NaN
notes: FORMULA: C10H16O4 CHARGE: -2

metaR r1018
product: MODEL1310110057#
name: Transport reaction
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_3eaed1c0_e93c_49c6_ad1f_426bd6b4fa70
is: SBO:0000252
name: SCD
boundary condition: true
is: O00767
constant: false
type: Species
is encoded by: hsa:6319
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR ABO5g
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.37
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
reversible: false
product: MODEL1310110057#
fast: false

metaR C142OHc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradeca dienoyl carnitine
type: Reaction

metaR HCO3 CLt
modifier: MODEL1310110057#
fast: false
product: MODEL1310110057#
is: SBO:0000185
name: bicarbonate transport (Cl-/HCO3- exchange)
kinetic law: MODEL1310110057#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM
type: Reaction
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_b625c801_2eb8_4bf1_be68_b7d2d071ca89
name: SLC34A1
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: Q7Z725
is encoded by: hsa:6569
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_4a107936_aeec_460b_bd62_3e7c7b7916a9
is encoded by: hsa:1650
constant: false
type: Species
boundary condition: true
name: DDOST
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P39656

http://identifiers.org/biomodels.db/MODEL1310110057#_2e5a9abf_42ba_45ae_b703_3e45b9f15b00
is: SBO:0000252
initial concentration: NaN
name: PLCB4
is: E2QRH8
boundary condition: true
is encoded by: hsa:5332
type: Species
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_13c62925_e953_4619_9dad_36c13c9591b2
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:29922
has only substance units: false
is: Q9Y5B8
type: Species
constant: false
name: NME7

metaR FAOXC5C5OHm
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C5OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_d461d23b_8147_415c_b36f_6aff4d55820b
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q5MY95
type: Species
initial amount: NaN
name: ENTPD8
is encoded by: hsa:377841
has only substance units: false

metaM ser L c
boundary condition: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: HMDB00187
is: CHEBI:17115
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
name: L-serine
has only substance units: false
initial concentration: 1.0

metaM ksi deg36 l
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
initial concentration: 1.0
is: CHEBI:12936
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
constant: false
name: keratan sulfate I, degradation product 36
initial amount: NaN
is: HMDB00143

metaM hom L c
is: HMDB00719
boundary condition: false
is: CHEBI:15699
initial concentration: 1.0
type: Species
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial amount: NaN
constant: false
is: SBO:0000247
name: L-homoserine
has only substance units: false

metaR HOCDACBP
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxyoctadecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM CE5126 x
type: Species
constant: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5126
name: (2R)-pristanoyl-CoA
initial concentration: 1.0
initial amount: NaN
is: CHEBI:12947
has only substance units: false
is: SBO:0000247
boundary condition: false

metaM nadh m
has only substance units: false
initial amount: NaN
name: Nicotinamide adenine dinucleotide - reduced
is: CHEBI:57945
constant: false
is: C00004
type: Species
is: SBO:0000247
is: HMDB01487
is: http://identifiers.org/pubchem.compound/3306
initial concentration: 1.0
boundary condition: false

metaR GLNALANaEx
fast: false
is: SBO:0000185
reactant: MODEL1310110057#
modifier: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000269
kinetic law: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)

metaM dhap x
is: HMDB01473
is: C00111
initial concentration: 1.0
is: CHEBI:57642
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3411
name: Dihydroxyacetone phosphate
is: SBO:0000247
type: Species

metaM ocdca c
has only substance units: false
constant: false
is: HMDB00827
is: CHEBI:25629
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
initial amount: NaN
type: Species
name: stearate

metaM frdp r
name: Farnesyl diphosphate
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:175763
is: HMDB00961
boundary condition: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
type: Species
has only substance units: false
is: C00448

http://identifiers.org/biomodels.db/MODEL1310110057#_cf0b6788_6547_4e1c_8a4e_00641013d9d6
initial amount: NaN
is: P14324
name: FDPS
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:2224

metaR HTDCACBP
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxytetradecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR r1574
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110057#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110057#
fast: false
type: Reaction
kinetic law: MODEL1310110057#

metaR PDE4
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.1.4.17
name: 3',5'-cyclic-nucleotide phosphodiesterase
type: Reaction
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110057#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.35
fast: false
is described by: ECO:0000269
modifier: MODEL1310110057#
reactant: MODEL1310110057#

metaM 3hpcoa m
is: SBO:0000247
is: HMDB06807
boundary condition: false
is: CHEBI:58528
initial amount: NaN
name: 3-hydroxypropanoyl-CoA(4-)
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_3cf32ef4_1b69_45e6_b524_e311cd6b3e9a
is encoded by: hsa:10587
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
constant: false
name: TXNRD2
initial amount: NaN

metaM xtsn c
constant: false
initial concentration: 1.0
boundary condition: false
name: xanthosine
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00299
type: Species
is: CHEBI:18107
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaM glcur e
is: HMDB00127
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15748
name: D-glucuronate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110057#_ab93565e_37c9_4cd8_8800_b83e3bf552ac
initial concentration: NaN
name: SLC27A4
has only substance units: false
boundary condition: true
is: Q6P1M0
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:10999
initial amount: NaN

metaR PRO Dtde
product: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
fast: false
reactant: MODEL1310110057#
reversible: true
name: D-proline transport, extracellular

metaM HC01602 c
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: SBO:0000247
initial amount: NaN
is: CHEBI:57454
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: C00234
name: 10-Formyltetrahydrofolate

metaR r1573
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110057#
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110057#
is: SBO:0000185
product: MODEL1310110057#

metaM pristcoa x
initial amount: NaN
name: pristanoyl coa
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
constant: false
boundary condition: false
is: CHEBI:51341

metaR TTDCPT2
reactant: MODEL1310110057#
reversible: false
modifier: MODEL1310110057#
type: Reaction
name: carnitine transferase
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR r0186
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
product: MODEL1310110057#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110057#
is: SBO:0000176
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
type: Reaction
fast: false

metaR G12MT2 L
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
product: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
fast: false
reversible: false
reactant: MODEL1310110057#
is described by: ECO:0000000

metaM dgtp c
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB01440
name: dGTP
is: CHEBI:16497
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
constant: false
is: C00286
is: SBO:0000247
boundary condition: false

metaM pheme e
name: Protoheme
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: C00032
is: CHEBI:17627
is: SBO:0000247
is: HMDB03178
type: Species
boundary condition: false
constant: false
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032

metaM c51crn e
initial amount: NaN
initial concentration: 1.0
name: tiglyl carnitine
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
is: HMDB02366
notes: FORMULA: C12H21NO4 CHARGE: 0
constant: false

metaM ksi pre13 g
boundary condition: false
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
constant: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 13
initial amount: NaN
is: HMDB00175
is: C00130
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:58053

metaM hom L e
is: SBO:0000247
is: CHEBI:15699
initial concentration: 1.0
is: HMDB00719
initial amount: NaN
name: L-homoserine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
boundary condition: false
has only substance units: false
constant: false
type: Species

metaR H2O2tp
reversible: true
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000000
product: MODEL1310110057#
name: hydrogen peroxide peroxisomal transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110057#_6a31322d_3a40_4709_95b3_140051d49300
type: Species
name: _H17063_1_c
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:H17063
initial concentration: NaN

metaR FAOXC101C8x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8:0)x
type: Reaction

metaM eipencoa x
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/24892790
constant: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
is: SBO:0000247
name: 2,5,8,11,14-eicosapentaenoylcoa

metaM ksi pre5 g
is: CHEBI:28067
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C101H164N7O75SX CHARGE: -2
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 5
boundary condition: false

metaM Lpipecol x
is: CHEBI:30913
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00716
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
name: L-pipecolic acid

metaR SUCRe
kinetic law: MODEL1310110057#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.20
is described by: ECO:0000269
modifier: MODEL1310110057#
name: sucrose hydrolyzing enxyme, extracellular
fast: false
reversible: false
reactant: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.10
notes: GENE_ASSOCIATION: (6476.1) or (8972.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.26 Confidence Level: 4 AUTHORS: PMID:1560017,PMID:3143729 NOTES:NCD

metaM eicostetcrn c
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB01356
initial amount: NaN
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
constant: false
is: SBO:0000247
is: CHEBI:57312
name: Eicosatetranoyl carnitine
type: Species

metaR PEPCKm
fast: false
is: SBO:0000176
type: Reaction
reversible: false
name: Phosphoenolpyruvate carboxykinase (GTP)
is version of: http://identifiers.org/ec-code/4.1.1.32
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000000
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
modifier: MODEL1310110057#

metaR XOLDIOLONEt
fast: false
product: MODEL1310110057#
reversible: true
name: lipid, flip-flop intracellular transport
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#

metaM 3mgcoa m
is: HMDB01057
is: CHEBI:57346
boundary condition: false
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
name: trans-3-methylglutaconyl-CoA(5-)
initial concentration: 1.0

metaM aicar c
boundary condition: false
is: CHEBI:58475
is: C04677
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: HMDB01517
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR EX crvnc LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC22:6 exchange
type: Reaction

metaM f1p c
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:18105
name: D-Fructose 1-phosphate
is: C01094
initial concentration: 1.0
is: HMDB01076
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00662 EHMN_ABBREVIATION: C01094
boundary condition: false

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaM ksii core4 pre8 g
is: SBO:0000247
initial amount: NaN
is: HMDB00175
is: C00130
notes: FORMULA: C83H134N7O61SX CHARGE: -2
is: CHEBI:58053
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 8
constant: false
type: Species

metaM 2mb2coa m
has only substance units: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
initial concentration: 1.0
is: HMDB02054
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: CHEBI:57337
boundary condition: false
name: 2-methylcrotonoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110057#_0f7aada1_9d66_4a05_a684_3e5bd28ca0ad
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:2983
has only substance units: false
initial amount: NaN
type: Species
is: Q02153
name: GUCY1B3

metaR GAMt1r
is described by: ECO:0000269
fast: false
product: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
name: glucosamine transport (uniport)
reversible: true
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110057#_8778bd6d_0ba9_4767_9a4b_1b3f5ea90847
name: ATIC
is: SBO:0000252
is encoded by: hsa:471
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: P31939

metaR r2079
product: MODEL1310110057#
modifier: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110057#
fast: false
reversible: true
kinetic law: MODEL1310110057#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110057#_325c898f_40a2_4c56_bfde_5da2364c03c0
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:9091
is encoded by: hsa:51227
type: Species
has only substance units: false
has part: B2RAU6
boundary condition: true
is encoded by: hsa:5277
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial concentration: NaN
is encoded by: hsa:5279
constant: false
has part: P57054

metaR r1571
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
is described by: ECO:0000000
product: MODEL1310110057#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM pheme c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: C00032
is: CHEBI:17627
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB03178
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
constant: false
name: Protoheme

metaR DCK2n
kinetic law: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.74
modifier: MODEL1310110057#
reversible: true
fast: false
product: MODEL1310110057#
reactant: MODEL1310110057#
name: Deoxycytidine kinase, nuclear (UTP)

http://identifiers.org/biomodels.db/MODEL1310110057#_4ed20c1d_8b69_4fe8_8397_9900cb61a50c
name: RPN1
initial amount: NaN
type: Species
has only substance units: false
is: P04843
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6184
constant: false
is: SBO:0000252

metaR TYRt
reactant: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000269
kinetic law: MODEL1310110057#
fast: false
reversible: true
is: SBO:0000185
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
type: Reaction
name: L-tyrosine transport

metaR RE3624M
type: Reaction
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
reactant: MODEL1310110057#
is: SBO:0000176
reversible: false
name: RE3624
kinetic law: MODEL1310110057#
is described by: ECO:0000000

metaM dgtp e
boundary condition: false
is: HMDB01440
initial concentration: 1.0
is: CHEBI:16497
constant: false
name: dGTP
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_f05f4a8d_c6bb_412e_a331_13dc67755154
type: Species
is: SBO:0000252
has only substance units: false
name: PPCS
initial concentration: NaN
is: Q9HAB8
is encoded by: hsa:79717
constant: false
initial amount: NaN
boundary condition: true

metaM c4dc c
is: HMDB02013
is: SBO:0000247
is: C02862
notes: FORMULA: C11H18NO6 CHARGE: -1
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
name: succinyl carnitine
is: http://identifiers.org/pubchem.compound/213144
constant: false

metaM CE1943 e
notes: FORMULA: C7H14NO2 CHARGE: 1 INCHI: InChI=1/C7H13NO2/c9-6-2-1-4-8-5-3-7-10/h6-8H,1-5H2/p+1 EHMN_ABBREVIATION: CE1943
name: spermidine dialdehyde
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: C00010
initial amount: NaN
is: SBO:0000247
is: HMDB01423
has only substance units: false
is: CHEBI:57287

http://identifiers.org/biomodels.db/MODEL1310110057#_9f091d93_410d_4984_b482_bd6d7d5d2b21
initial amount: NaN
is: SBO:0000297
has only substance units: false
is encoded by: hsa:3939
is encoded by: hsa:3945
has part: P07195
type: Species
constant: false
name: LDHA:LDHB
initial concentration: NaN
has part: P00338
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_9640e492_a476_4c24_a82d_a7ffa38036ff
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8876
name: VNN1
boundary condition: true
is: O95497
type: Species
initial amount: NaN
constant: false
initial concentration: NaN

metaR PROSTGH2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is: SBO:0000185
name: Prostaglandin H2 transport
reversible: true
type: Reaction
product: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
is described by: ECO:0000269
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_9ca57188_575e_46b2_9cb6_647ec9b107d4
constant: false
is: P54868
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3158
is: SBO:0000252
name: HMGCS2
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_2b086a56_25c8_40df_ab23_0310d061a5fb
initial amount: NaN
is: B4DP47
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:593
is: SBO:0000252
name: BCKDHA
type: Species
has only substance units: false

metaM aicar e
type: Species
initial concentration: 1.0
is: C04677
constant: false
is: HMDB01517
boundary condition: false
initial amount: NaN
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
has only substance units: false
is: CHEBI:58475
notes: FORMULA: C9H13N4O8P CHARGE: -2
is: SBO:0000247

metaR r0181
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110057#
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is: SBO:0000176
modifier: MODEL1310110057#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
reversible: true

metaM ksi deg17 l
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
name: keratan sulfate I, degradation product 17
is: HMDB00143
is: CHEBI:12936
constant: false
boundary condition: false
type: Species
initial amount: NaN

metaR r1570
kinetic law: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction

metaR DESAT22 1p
is: SBO:0000176
kinetic law: MODEL1310110057#
reversible: false
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
type: Reaction
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110057#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110057#_0512ab73_c7d1_43e4_be50_1af2b7da36f1
has only substance units: false
is encoded by: hsa:5052
constant: false
is: SBO:0000252
name: PRDX1
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN

metaM 2oxoadp c
is: SBO:0000247
is: CHEBI:57499
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00225
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
name: 2-oxoadipate(2-)

metaM dump c
is: C00365
constant: false
is: HMDB01409
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:246422
type: Species
name: dUMP
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
has only substance units: false

metaR FAOXC225m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

metaR ME2m
is version of: http://identifiers.org/ec-code/1.1.1.40
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
name: malic enzyme (NADP), mitochondrial
kinetic law: MODEL1310110057#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.38
fast: false
type: Reaction
product: MODEL1310110057#
reversible: false
reactant: MODEL1310110057#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110057#_0c6d2407_0b1d_4469_b5ed_16ac7798648c
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:763
boundary condition: true
is: P35218
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: CA5A

metaR RE2972M
type: Reaction
kinetic law: MODEL1310110057#
reversible: true
is: SBO:0000176
reactant: MODEL1310110057#
is described by: ECO:0000000
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.1.67
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
fast: false
product: MODEL1310110057#
name: RE2972

metaM m2mn l
has only substance units: false
type: Species
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
initial amount: NaN
is: HMDB06537
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110057#_b85b7af2_858e_4f69_a3a1_6c844ded12a4
boundary condition: true
is encoded by: hsa:8879
is: O95470
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
name: SGPL1
type: Species

metaR BILIRUBt2
modifier: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
is: SBO:0000185
name: bilirubin transport via bicarbonate countertransport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
reactant: MODEL1310110057#
reversible: true
kinetic law: MODEL1310110057#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_55f8cd5b_6789_430d_8d99_cdf29cf2886d
is encoded by: hsa:55350
is encoded by: hsa:8875
is: SBO:0000297
has only substance units: false
constant: false
is encoded by: hsa:8876
boundary condition: true
initial concentration: NaN
has part: A8K7W0
initial amount: NaN
type: Species
name: VNN3:VNN2:VNN1
has part: O95497

metaM forglu c
has only substance units: false
type: Species
name: N-Formimidoyl-L-glutamate
initial amount: NaN
is: CHEBI:18327
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
constant: false
is: HMDB00854
is: C00439
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110057#_10c8d003_1d7b_49cd_9cb5_857b1b625a14
is: SBO:0000252
is: P49189
is encoded by: hsa:223
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
name: ALDH9A1
initial concentration: NaN
constant: false

metaR r0892
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.1.2.27
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction
fast: false
product: MODEL1310110057#
is: SBO:0000185
reactant: MODEL1310110057#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_4f1a1394_9f7b_465f_b25f_69716b2a04e4
constant: false
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is: SBO:0000297
boundary condition: true
initial amount: NaN
is encoded by: hsa:51227
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_a06348d0_a80f_455b_9b6c_3a424447f4fd
initial concentration: NaN
is: Q8IUC8
type: Species
constant: false
name: GALNT13
is encoded by: hsa:114805
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_d5cf806b_8231_419a_83a5_22917094b3ef
type: Species
is encoded by: hsa:83733
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q9H1K4
constant: false
has only substance units: false
name: SLC25A18
is: SBO:0000252

metaM zymstnl r
constant: false
initial concentration: 1.0
name: 5alpha-cholest-8-en-3beta-ol
initial amount: NaN
is: HMDB06841
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
is: CHEBI:16608
type: Species

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_41a2f9c2_75b9_453d_807a_4b12bdce6089
is encoded by: hsa:3422
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
name: IDI1
initial concentration: NaN
is: Q13907

http://identifiers.org/biomodels.db/MODEL1310110057#_4848ed03_51c8_4d3b_8f10_81eb460766a7
is: SBO:0000252
is encoded by: hsa:27235
type: Species
name: COQ2
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q96H96
initial concentration: NaN

metaR MI1345PP
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.36
is: SBO:0000176
reactant: MODEL1310110057#
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
type: Reaction
product: MODEL1310110057#
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.56
fast: false
modifier: MODEL1310110057#

metaM q10 e
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
name: ubiquinone-10
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:46245
type: Species
is: HMDB01072
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_c07a342c_67b5_4439_952a_e17a83737a49
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:4512
constant: false
boundary condition: true
name: COX1
has only substance units: false
is: SBO:0000252
is: Q7GXY8

metaM mal L m
name: (S)-malate(2-)
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:15589
is: SBO:0000247
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: HMDB00156
initial amount: NaN
constant: false

metaM ocdca e
type: Species
is: CHEBI:25629
name: octadecanoate (n-C18:0)
is: HMDB00827
constant: false
is: C01530
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530

metaM c10dc c
boundary condition: false
name: sebacoyl carnitine
is: SBO:0000247
notes: FORMULA: C17H30NO6 CHARGE: -1
constant: false
initial amount: NaN
is: HMDB00651
type: Species
has only substance units: false
initial concentration: 1.0

metaM acgam6p c
is: SBO:0000247
is: CHEBI:57513
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
constant: false
name: N-acetyl-D-glucosamine 6-phosphate(2-)
is: HMDB01062

http://identifiers.org/biomodels.db/MODEL1310110057#_b245c224_34b7_409c_9d2a_0de57c5fb800
name: BCAT2
is encoded by: hsa:587
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is: O15382

metaR T4HCINNMFM
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
is: SBO:0000176
product: MODEL1310110057#
reversible: false
name: 4-hydroxycinnamate formation

metaM nm2masn g
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
is: C05884
constant: false
notes: FORMULA: C42H70N3O30X CHARGE: 0
boundary condition: false

metaR C161CPT2
reactant: MODEL1310110057#
name: transport of Hexadecenoyl-CoA into mitochondrial matrix
kinetic law: MODEL1310110057#
fast: false
type: Reaction
modifier: MODEL1310110057#
reversible: false
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
is described by: ECO:0000000

metaR RE1836X
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.176
is described by: ECO:0000000
type: Reaction
name: RE1836
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
product: MODEL1310110057#
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
reversible: true

metaM docohexcoa m
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
name: 2,4,7,10,13,16-docosahexenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110057#_1d8a1c61_3655_4ce6_b6a5_1a7c43842b68
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
is: P04818
initial concentration: NaN
is encoded by: hsa:7298
name: TYMS

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

metaR SUCCTD
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaR FAOXC161C141m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:1-->C14:1)m
type: Reaction

metaM hdd2crn m
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
type: Species
boundary condition: false
name: trans-Hexadec-2-enoyl carnitine
is: HMDB06317
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM icit x
name: isocitrate(3-)
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: HMDB00193
constant: false
is: CHEBI:16087
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM doco13ecoa x
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
name: 13-docosenoylcoa
is: http://identifiers.org/pubchem.compound/24892791
initial concentration: 1.0
is: SBO:0000247

metaM glcur c
is: HMDB00127
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
type: Species
name: D-glucuronate
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15748
has only substance units: false

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_b07d06ea_fbc6_4b76_806d_95d37d5cdfe1
constant: false
type: Species
has only substance units: false
name: XDH
initial amount: NaN
is: P47989
boundary condition: true
initial concentration: NaN
is encoded by: hsa:7498
is: SBO:0000252

metaR C161CPT1
is: SBO:0000176
kinetic law: MODEL1310110057#
fast: false
name: production of palmitoleoylcarnitine
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:TDV
modifier: MODEL1310110057#
reactant: MODEL1310110057#

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_ee1474c9_100b_4431_9afa_f1571a055bb0
is: Q9HCQ5
name: GALNT9
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:50614
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_2010b037_2999_4f8e_82d4_551c63ae2fb5
constant: false
initial concentration: NaN
is: P27987
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:3707
initial amount: NaN
name: ITPKB
is: SBO:0000252

metaM 2dodtricoa x
has only substance units: false
type: Species
name: 2,6,9-dodecatrienoylcoa
is: C05279
boundary condition: false
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: HMDB11123
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110057#_598bbdaa_e3d8_4d31_9fe4_81e0839c929a
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:T83654
constant: false
name: _T83654_1_m
initial concentration: NaN
type: Species

metaR SERGLNexR
modifier: MODEL1310110057#
name: L-Serine/Glutamine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110057#
reversible: true
is: SBO:0000185
reactant: MODEL1310110057#
type: Reaction
is described by: ECO:0000304
product: MODEL1310110057#
fast: false

metaM atp m
is: C00002
initial concentration: 1.0
is: CHEBI:57299
boundary condition: false
has only substance units: false
name: ATP(4-)
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00538

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaR GALASE4ly
type: Reaction
product: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110057#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#

metaR r2102
type: Reaction
fast: false
product: MODEL1310110057#
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000

metaR r1579
fast: false
product: MODEL1310110057#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110057#

metaM atp n
is: HMDB00538
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
is: CHEBI:57299
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
name: ATP(3-)
constant: false
initial amount: NaN
is: SBO:0000247

metaM nh4 n
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
name: ammonium
is: SBO:0000247
is: HMDB00051
is: CHEBI:28938
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
type: Species
initial concentration: 1.0

metaM phyt2ohcoa x
is: SBO:0000247
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)32(50)40(54)70-20-19-43-30(49)17-18-44-38(53)35(52)41(6,7)22-63-69(60,61)66-68(58,59)62-21-29-34(65-67(55,56)57)33(51)39(64-29)48-24-47-31-36(42)45-23-46-37(31)48/h23-29,32-35,39,50-52H,8-22H2,1-7H3,(H,43,49)(H,44,53)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/t26?,27?,28?,29-,32?,33-,34-,35+,39-/m1/s1 EHMN_ABBREVIATION: C07343
name: 2-hydroxyphytanoyl-CoA(4-)
is: HMDB01295
initial amount: NaN
is: CHEBI:57334
constant: false
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0

metaR CYSGLTH
product: MODEL1310110057#
fast: false
type: Reaction
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
is: SBO:0000176
name: Glutathione:cystine oxidoreductase
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110057#

metaM trdox c
is: CHEBI:18191
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: C00343
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
initial concentration: 1.0
type: Species
has only substance units: false
name: Oxidized thioredoxin
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_25858d16_befa_4c4b_acc0_9315a4792576
is encoded by: hsa:64902
constant: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
name: AGXT2
has only substance units: false
is: Q9BYV1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_fc8cf6cd_ed5c_467a_9439_f520f20fa3ae
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P23677
type: Species
is encoded by: hsa:3706
name: ITPKA
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_c7d131c2_2794_4b13_97c5_d17cea3064c6
has only substance units: false
type: Species
is encoded by: hsa:9058
boundary condition: true
initial amount: NaN
is: E7ETH5
constant: false
initial concentration: NaN
name: SLC13A2
is: SBO:0000252

metaM lnlncg e
is: SBO:0000247
constant: false
type: Species
is: CHEBI:32391
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
name: gamma-linolenate
boundary condition: false
initial amount: NaN
is: HMDB03073
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_cffdcc80_1beb_47ad_a14e_122cbd9b8133
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: Q9HC21
is encoded by: hsa:60386
initial concentration: NaN
type: Species
is: SBO:0000252
name: SLC25A19

http://identifiers.org/biomodels.db/MODEL1310110057#_313ebb22_927e_48a2_9d3b_eb9e81e57a09
initial concentration: NaN
has only substance units: false
is encoded by: hsa:51733
boundary condition: true
type: Species
name: UPB1
initial amount: NaN
is: B3KNC1
is: SBO:0000252
constant: false

metaR r2101
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110057#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110057#
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110057#

metaR EX glygn5 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 5 (glycogenin-2[1,4-Glc])
type: Reaction

metaR VALtec
fast: false
is: SBO:0000185
name: L-valine transport via diffusion (extracellular to cytosol)
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
is described by: ECO:0000269
modifier: MODEL1310110057#
reversible: true
product: MODEL1310110057#
type: Reaction

metaR H2MTer L
reversible: false
name: H2 mannosyltransferase, endoplasmic reticulum
fast: false
reactant: MODEL1310110057#
product: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
modifier: MODEL1310110057#
is described by: ECO:0000000

metaR S6T1g
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
product: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
reactant: MODEL1310110057#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110057#_00b86de2_8b43_4bb6_afe9_5238f09ec81f
name: MTHFD1
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4522
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is: P11586

http://identifiers.org/biomodels.db/MODEL1310110057#_58970ffe_af90_4d9d_b9ac_0ad3a2e03f2f
is: SBO:0000252
is encoded by: hsa:BE042354
type: Species
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
name: _BE042354_1_m
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_c
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
is: CHEBI:15347
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB01659
constant: false
has only substance units: false
type: Species
name: Type IIIA glycolipid

metaM nh4 m
has only substance units: false
constant: false
type: Species
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
name: Ammonium
boundary condition: false
is: C01342
initial concentration: 1.0
is: SBO:0000247
is: HMDB00051
is: CHEBI:28938
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_849f7c30_60a8_4820_9cd3_65562fa4725f
is: Q3I5F7
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: ACOT6
is encoded by: hsa:641372
initial concentration: NaN
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_ff5577d0_983e_48ea_8a38_f84a7d22a28a
type: Species
is encoded by: hsa:10998
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q9Y2P5
initial amount: NaN
name: SLC27A5
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_56309b23_0953_4487_8409_7c87ad1e9bed
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR UMPK5n
fast: false
is: SBO:0000176
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110057#
type: Reaction
name: UMP kinase (dATP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
product: MODEL1310110057#
reactant: MODEL1310110057#
reversible: true

metaM dcholcoa c
is: SBO:0000247
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial concentration: 1.0
constant: false
name: chenodeoxycholoyl coenzyme a
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:28701
boundary condition: false
is: HMDB06292

metaM uri e
boundary condition: false
initial concentration: 1.0
is: C00299
constant: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
type: Species
is: CHEBI:16704
name: Uridine
has only substance units: false
is: SBO:0000247
is: HMDB00296
initial amount: NaN

metaR r2100
product: MODEL1310110057#
reactant: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
is: SBO:0000185
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM tridcoa m
is: HMDB13109
is: SBO:0000247
notes: FORMULA: C34H56N7O17P3S CHARGE: -4
constant: false
name: tridecanoylcoa
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110057#_34fe1d07_1931_4b71_8f00_4d2c2b07d77c
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: P27707
constant: false
is: SBO:0000252
name: DCK
initial amount: NaN
is encoded by: hsa:1633

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_6b0c4bc1_78de_479a_986b_1561e7c08c7a
type: Species
initial concentration: NaN
constant: false
name: BDH1
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:622
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_40df961d_3f0b_4f2d_9fae_0ec53b443a48
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: GGT2
is encoded by: hsa:728441
type: Species
initial concentration: NaN
constant: false

metaM lnlncg c
boundary condition: false
initial amount: NaN
name: gamma-linolenate
initial concentration: 1.0
has only substance units: false
is: HMDB03073
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: CHEBI:32391
constant: false
is: SBO:0000247
type: Species

metaR r2060
is: SBO:0000185
fast: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110057#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110057#
modifier: MODEL1310110057#
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

http://identifiers.org/biomodels.db/MODEL1310110057#_f4824ad3_d09d_4ff2_aba9_86be1ada678e
initial amount: NaN
name: GAPDH
is: SBO:0000252
is: E7EUT4
type: Species
constant: false
boundary condition: true
is encoded by: hsa:2597
initial concentration: NaN
has only substance units: false

metaM idp e
name: IDP(3-)
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
type: Species
is: CHEBI:58280
is: HMDB03335
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR C10DCc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoylcarnitine
type: Reaction

metaR r2393
is: SBO:0000185
type: Reaction
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110057#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_e81592c4_fd1d_43f6_a1d9_55cbc060b52f
constant: false
is: P16260
type: Species
initial amount: NaN
is encoded by: hsa:8034
has only substance units: false
boundary condition: true
name: SLC25A16
initial concentration: NaN
is: SBO:0000252

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaM ksi deg6 l
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
type: Species
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I, degradation product 6
initial amount: NaN
has only substance units: false
is: HMDB00143
constant: false
is: CHEBI:12936
boundary condition: false

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaM m2mpdol L c
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28049
is: SBO:0000247
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
notes: FORMULA: C1420H2328N20O320P20 CHARGE: -20
type: Species
has only substance units: false
boundary condition: false

metaR RE3006M
kinetic law: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE3006
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110057#
is: SBO:0000176
reactant: MODEL1310110057#

metaR COt
name: CO transporter via diffusion
product: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
reactant: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false

metaR ACP1 FMN
type: Reaction
is: SBO:0000176
modifier: MODEL1310110057#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.2
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
name: acid phosphatase (FMN)
is described by: ECO:0000254
product: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:8522318 NOTES:INVALID ECO TERM: IFH

http://identifiers.org/biomodels.db/MODEL1310110057#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_e
initial amount: NaN
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
boundary condition: false
is: SBO:0000247
name: Type IIIA glycolipid
is: HMDB01659
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: CHEBI:15347

metaR PI45P5P
fast: false
is described by: ECO:0000000
product: MODEL1310110057#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.1.3.36
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
kinetic law: MODEL1310110057#
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
reversible: false

metaR SUCCOAPET
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaR CTPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110057#
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: CTP diffusion in nucleus
reactant: MODEL1310110057#
product: MODEL1310110057#

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

metaR r1575
product: MODEL1310110057#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110057#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110057#
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110057#_a6fcb211_4573_480f_b386_6376cfbea42d
is: Q9NWU1
constant: false
type: Species
initial amount: NaN
boundary condition: true
name: OXSM
initial concentration: NaN
is encoded by: hsa:54995
is: SBO:0000252
has only substance units: false

metaR r2063
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
modifier: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110057#

metaM uri c
initial amount: NaN
is: C00299
constant: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
name: Uridine
has only substance units: false
is: SBO:0000247
is: HMDB00296
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:16704

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_31b200c4_ade6_45d1_8e6f_cd1645f12848
is encoded by: hsa:3613
initial amount: NaN
initial concentration: NaN
name: IMPA2
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is: O14732
boundary condition: true

metaR PYRt2r
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
product: MODEL1310110057#
modifier: MODEL1310110057#
reversible: true
reactant: MODEL1310110057#
name: pyruvate reversible transport via proton symport

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaR B3GNT310g
reversible: false
kinetic law: MODEL1310110057#
product: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
is described by: ECO:0000254
is: SBO:0000176
type: Reaction
reactant: MODEL1310110057#
modifier: MODEL1310110057#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus

metaR r2106
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reactant: MODEL1310110057#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110057#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
kinetic law: MODEL1310110057#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110057#_46a5b697_8a66_409c_b5c6_54258a7e4122
boundary condition: true
is: Q86WU2
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:197257
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: LDHD

http://identifiers.org/biomodels.db/MODEL1310110057#_2bb77daf_5e2e_42de_8339_57ef87e7934e
type: Species
constant: false
has only substance units: false
boundary condition: true
name: DGKZ
initial amount: NaN
is: B7Z6M3
is encoded by: hsa:8525
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_b866328a_c68f_4825_99e2_daf715739470
name: PFKFB1
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:5207
initial concentration: NaN
constant: false
is: P16118
type: Species

metaM tetdec2crn c
constant: false
has only substance units: false
type: Species
is: HMDB02014
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C21H37NO4 CHARGE: 0
name: tetradecadienoyl carnitine
boundary condition: false

metaM gam6p c
is: CHEBI:12962
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
type: Species
constant: false
has only substance units: false
is: HMDB01254
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: D-Glucosamine 6-phosphate
boundary condition: false

metaR r1576
product: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110057#
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110057#
type: Reaction

metaR r2105
product: MODEL1310110057#
reversible: true
fast: false
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110057#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110057#_976482e7_8a1a_4a2b_b93f_f85d9597d3f9
has only substance units: false
type: Species
is encoded by: hsa:54
is: SBO:0000252
boundary condition: true
constant: false
name: ACP5
initial concentration: NaN
initial amount: NaN
is: P13686

metaM idp c
is: CHEBI:58280
type: Species
is: HMDB03335
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial amount: NaN
is: SBO:0000247
name: IDP(3-)

http://identifiers.org/biomodels.db/MODEL1310110057#_284988f7_e419_4bac_9628_4d04cacdcfc0
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:AI291895
name: _AI291895_1_c

metaR FUT99g
is described by: ECO:0000269
kinetic law: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
reversible: false
type: Reaction
modifier: MODEL1310110057#
name: Alpha-(1,3)-fucosyltransferase
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.152
product: MODEL1310110057#

metaM 2oxoadp m
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
type: Species
is: CHEBI:57499
has only substance units: false
initial concentration: 1.0
is: HMDB00225
boundary condition: false
name: 2-oxoadipate(2-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_884d8d49_08bb_45f6_9491_2beabadc8b9a
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2762
name: GMDS
has only substance units: false
initial concentration: NaN
constant: false
is: O60547
initial amount: NaN

metaR EX 3octdece1crn
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-octadecenoyl carnitine
type: Reaction

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_00e6c991_8d24_4d6d_a8c0_d069cdba7987
is encoded by: hsa:8802
is: P53597
constant: false
name: SUCLG1
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR r2104
fast: false
type: Reaction
product: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000185
kinetic law: MODEL1310110057#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110057#_98340896_4020_4b65_8679_3120e7708610
is encoded by: hsa:51166
initial amount: NaN
type: Species
has only substance units: false
is: Q4W5N8
boundary condition: true
name: AADAT
constant: false
initial concentration: NaN
is: SBO:0000252

metaR CERT2rt
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.11.1
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
product: MODEL1310110057#
name: ceramide transport protein
modifier: MODEL1310110057#

metaR RE0827E
fast: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
reversible: false
product: MODEL1310110057#
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110057#
is: SBO:0000176
name: RE0827
type: Reaction
is described by: ECO:0000000

metaR PRO1xm
fast: false
is version of: http://identifiers.org/ec-code/1.5.99.8
modifier: MODEL1310110057#
name: proline oxidase (NAD), mitochondrial
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD
is: SBO:0000176
product: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction
reversible: false
is described by: ECO:0000254
reactant: MODEL1310110057#

metaR EX 3hexdcrn
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecanoyl carnitine
type: Reaction

metaM ksi deg3 l
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB06529
is: CHEBI:50570
name: keratan sulfate I, degradation product 3
notes: FORMULA: C233H371N16O205S12 CHARGE: -13

http://identifiers.org/biomodels.db/MODEL1310110057#_eb5698ff_d993_4cad_9171_96d3d416cf07
initial concentration: NaN
initial amount: NaN
constant: false
name: ATP5G1
is encoded by: hsa:516
has only substance units: false
is: P05496
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_07273950_91eb_46af_ac2c_0a563a1095ce
is: SBO:0000252
is encoded by: hsa:84264
boundary condition: true
type: Species
constant: false
initial concentration: NaN
name: HAGHL
has only substance units: false
initial amount: NaN

metaM estradiol c
initial amount: NaN
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
is: SBO:0000247
is: HMDB00151
name: estradiol
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:16469

http://identifiers.org/biomodels.db/MODEL1310110057#_39a28687_fcb5_4b3d_955e_2f99229736d1
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: NDUFS7
constant: false
type: Species
is: O75251
is: SBO:0000252
is encoded by: hsa:374291

metaM tddedi2coa m
is: SBO:0000247
constant: false
type: Species
has only substance units: false
is: HMDB00792
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: trans2,6dodecadienoylcoa
is: C08277

http://identifiers.org/biomodels.db/MODEL1310110057#_fcc8c24f_5845_4d20_8514_75ef3abddf52
is: P30519
is: SBO:0000252
is encoded by: hsa:3163
constant: false
initial concentration: NaN
name: HMOX2
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species

metaR TRIODTHYt2
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reversible: true
type: Reaction
modifier: MODEL1310110057#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
name: T3 transport via facilitated diffusion
is described by: ECO:0000269
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_d62442d7_4191_4853_bad0_ecd04238303a
constant: false
has only substance units: false
initial amount: NaN
is: E7EPT3
is: SBO:0000252
name: ALDH7A1
initial concentration: NaN
type: Species
is encoded by: hsa:501
boundary condition: true

metaR FALDH
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110057#
name: formaldehyde dehydrogenase
fast: false
product: MODEL1310110057#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_bc14ca27_0dcc_48fd_9a1c_e08207ef24cf
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2523
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
name: FUT1
type: Species
is: Q6IZA2

metaR LNLNCAt
is: SBO:0000185
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110057#
reversible: true
kinetic law: MODEL1310110057#
type: Reaction
fast: false
reactant: MODEL1310110057#
is described by: ECO:0000000

metaR r2103
type: Reaction
modifier: MODEL1310110057#
reversible: true
product: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM tetdec2crn e
has only substance units: false
constant: false
notes: FORMULA: C21H37NO4 CHARGE: 0
is: HMDB05066
name: tetradecadienoyl carnitine
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR CRNCAR3tp
reversible: false
name: carnitine-propcarnitine carrier, peroxisomal
product: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:copied from NCD's CRNCARtp NJ
reactant: MODEL1310110057#

metaR EX CE5869 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lysyl-proline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_0e101eb4_b556_4742_bc4f_2a5a8d174804
name: SMPD3
is: A8K0T6
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:55512
type: Species
initial amount: NaN
initial concentration: NaN

metaR FAOXC184m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

metaM HC00361 c
name: sedoheptulose 1,7-bisphosphate(4-)
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
is: CHEBI:58335
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_d13b9bff_4ffd_4341_b8ea_85f48e77e33f
is: SBO:0000252
is: Q01968
name: OCRL
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:4952
constant: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_e1e4af8c_8b3f_4a39_9395_d2e368fbe2f3
is encoded by: hsa:6389
has part: O14521
is encoded by: hsa:6391
type: Species
initial concentration: NaN
name: SDHA:SDHB:SDHC:SDHD
constant: false
is: SBO:0000297
is encoded by: hsa:6390
has part: Q99643
has part: P31040
has only substance units: false
boundary condition: true
initial amount: NaN
has part: P21912
is encoded by: hsa:6392

http://identifiers.org/biomodels.db/MODEL1310110057#_4bf4a464_d75b_4fbf_bdf6_543c30752fdf
is: P22392
type: Species
is encoded by: hsa:4831
name: NME2
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM kynate c
initial amount: NaN
has only substance units: false
type: Species
constant: false
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
is: HMDB00715
name: kynurenate
initial concentration: 1.0
is: CHEBI:58454
is: SBO:0000247
boundary condition: false

metaM succoa m
is: CHEBI:57292
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB01022
name: Succinyl-CoA
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_5554b86e_c8f1_4e06_8044_5b2a16d33b71
has only substance units: false
initial amount: NaN
type: Species
name: HPRT1
initial concentration: NaN
boundary condition: true
is: P00492
constant: false
is: SBO:0000252
is encoded by: hsa:3251

http://identifiers.org/biomodels.db/MODEL1310110057#_6e012a4f_8093_4eca_a71d_2a0e08d4c051
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AW277253
initial concentration: NaN
boundary condition: true
type: Species
name: _AW277253_1_c

metaR r1578
product: MODEL1310110057#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110057#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR ACCOAtr
type: Reaction
is: SBO:0000185
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ changed name from ACCOArt to ACCOAtr for consistency - NCD
is described by: ECO:0000000
product: MODEL1310110057#
modifier: MODEL1310110057#
name: acetyl-coa transport
kinetic law: MODEL1310110057#
fast: false
reversible: true

metaM thbpt4acam c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: 4a-hydroxytetrahydrobiopterin
is: SBO:0000247
is: CHEBI:15374
is: HMDB02281
constant: false
boundary condition: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
type: Species

metaM idp n
has only substance units: false
is: CHEBI:58280
boundary condition: false
is: HMDB03335
type: Species
name: IDP(3-)
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247

metaR HSD17B4x
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110057#
reversible: false
name: hydroxysteroid (17-beta) dehydrogenase 4
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
modifier: MODEL1310110057#
type: Reaction

metaM r5p r
constant: false
name: alpha-D-Ribose 5-phosphate
initial concentration: 1.0
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
type: Species
is: SBO:0000247
is: CHEBI:18189
is: HMDB00618
initial amount: NaN
boundary condition: false
has only substance units: false

metaM ca2 c
is: CHEBI:29108
is: HMDB00464
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
boundary condition: false
name: calcium(2+)
constant: false
has only substance units: false
initial amount: NaN

metaM CE4790 m
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
has only substance units: false
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:57923
initial amount: NaN
type: Species
initial concentration: 1.0

metaR O2t
product: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110057#
name: o2 transport (diffusion)
reversible: true
reactant: MODEL1310110057#
type: Reaction

metaM estradiol e
name: estradiol
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:16469
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
is: HMDB00151

http://identifiers.org/biomodels.db/MODEL1310110057#_e6fb0e85_7137_4398_9178_bdae7ef82095
constant: false
is encoded by: hsa:6391
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: SDHC
is: Q99643

http://identifiers.org/biomodels.db/MODEL1310110057#_f502b997_a861_4b9b_9d16_4e4f15774684
is encoded by: hsa:1962
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q9NY65
constant: false
name: EHHADH
type: Species

metaR SPMTDe
reactant: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
fast: false
is described by: ECO:0000134
reversible: true
is: SBO:0000185
name: SPMTDe
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR 3HKYNAKGAT
is: SBO:0000176
type: Reaction
is described by: ECO:0000304
reversible: false
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.6.1.64
fast: false
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.6.1.7
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
product: MODEL1310110057#

metaR HEXDCRNe
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecanoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_04bf0216_cf89_4b48_adbc_ca0367c6d080
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:4718
is: Q549M5
name: NDUFC2
constant: false
type: Species
boundary condition: true

metaM leugly c
constant: false
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/97364
boundary condition: false
notes: FORMULA: C8H16N2O3 CHARGE: 0
name: Leucylglycine
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_196f9b49_0f22_42ad_9e33_1079f8ee6909
name: ACAT2
is encoded by: hsa:39
is: SBO:0000252
constant: false
is: Q9BWD1
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_3022bf0e_b57d_4f48_9c0d_058895e15a55
type: Species
is encoded by: hsa:6390
has only substance units: false
is: P21912
is: SBO:0000252
name: SDHB
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR NADtpu
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
name: NAD transporter, peroxisome
product: MODEL1310110057#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110057#_c466796a_9bd1_43ef_9a3b_257a58079c1e
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
name: _BF195998_1_x
boundary condition: true
initial concentration: NaN
is encoded by: hsa:BF195998
type: Species

metaR FRDPtcr
reversible: true
type: Reaction
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
is: SBO:0000185
kinetic law: MODEL1310110057#
is described by: ECO:0000134
product: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
fast: false

metaM ocdececrn c
initial amount: NaN
constant: false
name: 11-octadecenoyl carnitine
boundary condition: false
type: Species
notes: FORMULA: C25H47NO4 CHARGE: 0
is: HMDB06351
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaR PYRt2m
modifier: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
reversible: true
is: SBO:0000185
fast: false
name: pyruvate mitochondrial transport via proton symport
type: Reaction
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
is described by: ECO:0000000

metaR GALASE16ly
kinetic law: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110057#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
modifier: MODEL1310110057#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR SERtN1
is described by: ECO:0000269
is: SBO:0000185
name: Serine transport (Na, H coupled)
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
fast: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
reversible: true
modifier: MODEL1310110057#

metaR GRTTx
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.1
product: MODEL1310110057#
fast: false
modifier: MODEL1310110057#
is described by: ECO:0000134
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
reversible: false
name: geranyltranstransferase
reactant: MODEL1310110057#

metaR NRPPHRt4 2 r
is: SBO:0000185
product: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000269
modifier: MODEL1310110057#
fast: false
name: Norepinephrine reversible transport in via sodium symport (1:2)

metaR FAOXC205C185m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:5)m
type: Reaction

metaM ca2 e
is: CHEBI:29108
has only substance units: false
is: HMDB00464
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
name: calcium(2+)
boundary condition: false
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
initial amount: NaN

metaR ATPS4m
is described by: ECO:0000134
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.3.14
name: ATP synthase (four protons for one ATP)
notes: GENE_ASSOCIATION: (513.1 and 498.2 and 506.1 and 509.2 and 514.1 or 498.2 and 513.2 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 514.2 and 506.1 or 498.2 and 513.2 and 506.1 and 509.2 and 514.1 or 513.2 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 498.1 and 506.1 and 509.2 and 514.1 or 513.1 and 498.2 and 514.2 and 506.1 and 509.2 or 513.1 and 498.2 and 509.1 and 506.1 and 514.1 or 498.2 and 509.1 and 513.2 and 506.1 and 514.1 or 513.2 and 498.1 and 506.1 and 509.2 and 514.1 or 513.2 and 514.2 and 506.1 and 509.2 and 498.3 or 513.2 and 506.1 and 509.2 and 498.3 and 514.1 or 513.1 and 509.1 and 506.1 and 498.3 and 514.1 or 509.1 and 513.2 and 514.2 and 506.1 and 498.3 or 513.1 and 498.2 and 509.1 and 514.2 and 506.1 or 513.1 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 506.1 and 514.1 or 513.1 and 506.1 and 509.2 and 498.3 and 514.1 or 509.1 and 513.2 and 506.1 and 498.3 and 514.1 or 513.1 and 514.2 and 506.1 and 509.2 and 498.3 or 509.1 and 513.2 and 498.1 and 506.1 and 514.1 or 513.1 and 509.1 and 514.2 and 506.1 and 498.3 or 498.2 and 509.1 and 513.2 and 514.2 and 506.1 or 509.1 and 513.2 and 498.1 and 514.2 and 506.1) and (10632.1 and 4905.1 and 10476.1 and 9551.3 and 522.5 and 516.2 and 521.1 and 515.1 or 518.3 and 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 9551.3 and 522.3 or 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 517.2 and 9551.2 and 522.3 or 10632.1 and 4905.1 and 10476.1 and 522.5 and 9551.2 and 518.2 and 521.1 and 515.1 or 4905.1 and 515.2 and 10476.2 and 516.2 and 521.1 and 10632.1 and 9551.3 and 522.5 or 518.3 and 4905.1 and 9551.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 522.4 or 10632.1 and 4905.1 and 10476.1 and 9551.1 and 522.2 and 515.2 and 518.2 and 521.1 or 518.3 and 10632.1 and 4905.1 and 10476.1 and 515.3 and 9551.2 and 522.4 and 521.1 or 10632.1 and 4905.1 and 10476.1 and 515.3 and 522.2 and 9551.3 and 518.2 and 521.1 or 4905.1 and 9551.1 and 10476.2 and 522…
kinetic law: MODEL1310110057#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.14
is version of: http://identifiers.org/ec-code/3.6.4.6
reactant: MODEL1310110057#
modifier: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000185

metaM vitd3 e
initial concentration: 1.0
is: HMDB00876
boundary condition: false
name: calciol
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:28940
is: SBO:0000247
type: Species
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1

metaR B3GNT12g
is: SBO:0000176
reactant: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (10678.1) or (10678.2) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
fast: false
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.149
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
modifier: MODEL1310110057#
reversible: false

metaR PYRt2p
product: MODEL1310110057#
reactant: MODEL1310110057#
reversible: true
kinetic law: MODEL1310110057#
name: pyruvate peroxisomal transport via proton symport
fast: false
type: Reaction
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12705896,PMID:12739169,PMID:9786900 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000185

metaM trdox m
has only substance units: false
initial amount: NaN
boundary condition: false
name: Oxidized thioredoxin
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
is: CHEBI:18191

metaR EX retinol cis 11 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cis-11-retinol exchange
type: Reaction

metaR DOLGLCP Lter
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)
reversible: false
product: MODEL1310110057#
type: Reaction

metaR C161CRN2t
is: SBO:0000185
reversible: false
product: MODEL1310110057#
kinetic law: MODEL1310110057#
name: C161 transport into the mitochondria
modifier: MODEL1310110057#
type: Reaction
fast: false
reactant: MODEL1310110057#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110057#_1d5adf17_9f1b_487f_82b4_f2e183306aa5
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:30
is: Q96CA6
initial amount: NaN
initial concentration: NaN
constant: false
name: ACAA1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_d2e79c48_c1a8_4225_b7f9_68927cbb0ba0
boundary condition: true
is: Q8NBL9
is encoded by: hsa:94005
name: PIGS
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

metaR DM btn
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for biotin
type: Reaction

metaR DM pnto R
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for (R)-Pantothenate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_40940112_e3d0_40c5_a317_d7f459541a97
initial amount: NaN
is encoded by: hsa:2982
type: Species
is: SBO:0000297
name: GUCY1B2:GUCY1A3
initial concentration: NaN
is encoded by: hsa:2974
has part: D6RDW3
boundary condition: true
constant: false
has only substance units: false

metaM ethamp r
name: O-phosphonatoethanaminium(1-)
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00224
is: CHEBI:58190

metaM HC02207 c
is: CHEBI:27555
name: prostaglandin-c2
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955

metaM nh4 x
is: SBO:0000247
is: HMDB00051
type: Species
is: C01342
has only substance units: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
name: Ammonium
is: CHEBI:28938

metaM uri n
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 INCHI: InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: CHEBI:16704
name: uridine
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00296
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_431187e3_137d_4d37_b57b_e3220db012f4
boundary condition: true
name: GLRX
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2745
is: P35754
initial concentration: NaN

metaR GALASE20ly
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR ACCOAtn
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110057#
name: acetyl-CoA transport, nuclear
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110057#_e278310a_8a25_4c41_ac18_7f8037ea2a35
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
constant: false
name: PDE9A
is encoded by: hsa:5152

metaM atp r
initial amount: NaN
name: ATP(4-)
type: Species
is: C00002
constant: false
has only substance units: false
is: CHEBI:57299
is: SBO:0000247
is: HMDB00538
boundary condition: false
initial concentration: 1.0

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

metaR NACHEXA15ly
reversible: false
type: Reaction
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
fast: false
kinetic law: MODEL1310110057#
name: beta-N-acetylhexosaminidase A, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110057#

metaM dcholcoa r
is: CHEBI:28701
initial amount: NaN
type: Species
boundary condition: false
name: chenodeoxycholoyl coenzyme a
is: SBO:0000247
has only substance units: false
is: HMDB06292
initial concentration: 1.0
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
constant: false

metaR HSD3A2r
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110057#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is: SBO:0000176
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.1.1.225
product: MODEL1310110057#

metaR 2HBt2
is: SBO:0000185
type: Reaction
modifier: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
fast: false
kinetic law: MODEL1310110057#
is described by: ECO:0000269
reactant: MODEL1310110057#
product: MODEL1310110057#
name: 2-hydroxybutyrate cotransport with proton

http://identifiers.org/biomodels.db/MODEL1310110057#_2a869dee_173b_4aa9_bf28_c82b6cdf3495
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is: P14410
boundary condition: true
type: Species
is encoded by: hsa:6476
has only substance units: false
name: SI

metaM vitd3 c
type: Species
boundary condition: false
is: HMDB00876
name: calciol
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28940
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1

metaM c101coa c
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
name: decenoylcoa
boundary condition: false
is: HMDB00651
is: SBO:0000247
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_4f783ac2_e883_4a07_aaee_4b532c96d650
is: SBO:0000252
is: P36957
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1743
boundary condition: true
name: DLST
type: Species
constant: false
initial amount: NaN

metaM dd5ecoa m
is: HMDB13028
has only substance units: false
is: C01942
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
initial concentration: 1.0
name: 5-dodecenoylcoa
boundary condition: false

metaR CLOHtex2
modifier: MODEL1310110057#
name: chloride transport via hydroxide countertransport (2:1)
is described by: ECO:0000304
fast: false
reversible: false
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reactant: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000185

metaM 3ddecdicoa m
is: SBO:0000247
is: C05280
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
constant: false
is: HMDB03952
name: 3,6-dodecadienoylcoa
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM acetone m
name: acetone
is: HMDB01659
is: CHEBI:15347
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207

http://identifiers.org/biomodels.db/MODEL1310110057#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_g
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
has only substance units: false
is: CHEBI:57847
boundary condition: false
initial concentration: 1.0
is: HMDB00304
name: Type IIIA glycolipid

metaR DMHPTCRNt
type: Reaction
is described by: ECO:0000000
product: MODEL1310110057#
name: 2,6 dimethylheptanoyl crn transport
fast: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES:dmhptcoa is 'special' because its biochemical fat isn't known NJ
reversible: true
is: SBO:0000185
reactant: MODEL1310110057#

metaR CERT1rt
is: SBO:0000185
name: ceramide transport protein
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
product: MODEL1310110057#
reversible: true
is described by: ECO:0000304
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110057#

metaR r1693
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
modifier: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_metaM_acgalfucgalacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
type: Species
is: CHEBI:61648
name: (Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C72H125N4O41FULLRCO CHARGE: 0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_8f2260f8_73e4_4048_88bf_0ef6bcc8280a
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1384
initial concentration: NaN
type: Species
name: CRAT
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_b4b06b76_195d_47b6_b18a_82f64e399eb1
has only substance units: false
initial amount: NaN
constant: false
name: SLC43A2
is: SBO:0000252
is encoded by: hsa:124935
is: Q8N370
boundary condition: true
type: Species
initial concentration: NaN

metaR NDPK8n
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110057#
is described by: ECO:0000304
reactant: MODEL1310110057#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
kinetic law: MODEL1310110057#
is: SBO:0000176
product: MODEL1310110057#

metaR THCHOLSTOICtm
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110057#
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110057#
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110057#

metaR FAOXC102C101m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaR ARACHDt2
reactant: MODEL1310110057#
is: SBO:0000185
name: fatty acid transport via diffusion
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
fast: false
product: MODEL1310110057#
kinetic law: MODEL1310110057#

metaM eicostetcrn m
has only substance units: false
is: SBO:0000247
is: CHEBI:57312
constant: false
name: Eicosatetranoyl carnitine
initial amount: NaN
type: Species
boundary condition: false
is: HMDB01356
initial concentration: 1.0
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1

metaR GLYCtm
is: SBO:0000185
kinetic law: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
is described by: ECO:0000000
reversible: true
type: Reaction
name: glycerol transport
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV

metaR PHCHGSm
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
fast: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110057#

metaR MCCCrm
type: Reaction
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000269
modifier: MODEL1310110057#
reversible: true
product: MODEL1310110057#
fast: false
name: methylcrotonoyl-CoA carboxylase, mitochondrial
is version of: http://identifiers.org/ec-code/6.4.1.4
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110057#_66da468d_423e_4486_805b_a718bd1e18c0
name: DLD:DLST:OGDH:PDHX
type: Species
has part: B4E3E9
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:4967
is: SBO:0000297
initial amount: NaN

metaR SUCOAS1m
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
reversible: true
name: Succinate--CoA ligase (GDP-forming)
is described by: ECO:0000000
reactant: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176

metaM leugly e
is: http://identifiers.org/pubchem.compound/97364
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C8H16N2O3 CHARGE: 0
name: Leucylglycine
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR RE1523M
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
name: RE1523
product: MODEL1310110057#
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_09982af4_c32c_4f82_9322_cdd93e7f1f82
initial concentration: NaN
is encoded by: hsa:586
initial amount: NaN
is: P54687
boundary condition: true
name: BCAT1
is: SBO:0000252
constant: false
has only substance units: false
type: Species

metaR PHYCBOXL
reactant: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
name: L-Phenylalanine carboxy-lyase
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.28
is: SBO:0000176

metaR FUMm
reversible: true
is: SBO:0000176
modifier: MODEL1310110057#
name: fumarase, mitochondrial
reactant: MODEL1310110057#
fast: false
type: Reaction
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/4.2.1.2
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
kinetic law: MODEL1310110057#
is described by: ECO:0000134

metaR ALR2
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.1.1.2
modifier: MODEL1310110057#
fast: false
type: Reaction
name: aldose reductase (methylglyoxal)
reversible: false
reactant: MODEL1310110057#
is: SBO:0000176
product: MODEL1310110057#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.21
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110057#_6348de80_ba24_435d_a301_d36fe6491fb4
initial amount: NaN
has only substance units: false
is: P04183
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: TK1
is encoded by: hsa:7083
type: Species

metaR NACHEXA11ly
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: false
fast: false
is described by: ECO:0000000
modifier: MODEL1310110057#
name: beta-N-acetylhexosaminidase A, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is: SBO:0000176

metaM dgtp n
initial concentration: 1.0
is: HMDB01440
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: dGTP
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: C00286
is: CHEBI:16497

http://identifiers.org/biomodels.db/MODEL1310110057#_a884bd98_35d8_4c3e_b8f7_827514ab410f
is: Q4KWH8
is encoded by: hsa:23007
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: PLCH1
constant: false
type: Species
boundary condition: true
initial amount: NaN

metaR FAOXC102m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_d7306250_4b90_483c_b67f_3f103d8f831f
is: SBO:0000252
boundary condition: true
is encoded by: hsa:79814
type: Species
initial amount: NaN
is: Q9BSE5
has only substance units: false
initial concentration: NaN
constant: false
name: AGMAT

http://identifiers.org/biomodels.db/MODEL1310110057#_2fadeabd_7c0a_4c3c_8003_53307b865774
has only substance units: false
type: Species
boundary condition: true
is: P00374
name: DHFR
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1719
constant: false
initial concentration: NaN

metaM 35cgmp c
type: Species
initial amount: NaN
is: CHEBI:57746
initial concentration: 1.0
boundary condition: false
name: 3',5'-cyclic GMP(1-)
is: HMDB01314
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942

http://identifiers.org/biomodels.db/MODEL1310110057#_388132be_a4f9_42a5_bcf3_999f72e325b9
name: VNN2
type: Species
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:8875
initial concentration: NaN
has only substance units: false
is: O95498
is: SBO:0000252

metaR EHGLAT2m
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
type: Reaction
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000304
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
reversible: false
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110057#
is: SBO:0000176
fast: false

metaR ALR3
name: aldose reductase (acetol)
is: SBO:0000176
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.1.1.2
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.21
reversible: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
product: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
is described by: ECO:0000269

metaM dudp c
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: CHEBI:60471
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: C01346
constant: false
is: SBO:0000247
is: HMDB01000
name: dUDP
boundary condition: false
type: Species

metaM dag hs r
is: SBO:0000247
is: CHEBI:18035
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
name: diglyceride
boundary condition: false
has only substance units: false

metaR r0179
reactant: MODEL1310110057#
modifier: MODEL1310110057#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.27
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110057#
product: MODEL1310110057#
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16

http://identifiers.org/biomodels.db/MODEL1310110057#_59ee3109_4607_426f_9068_841dad9523b0
is encoded by: hsa:26275
name: HIBCH
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q6NVY1

http://identifiers.org/biomodels.db/MODEL1310110057#_727792e1_8252_4db3_ae4e_c6862ea9ba25
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is: Q96NR8
has only substance units: false
is encoded by: hsa:145226
initial amount: NaN
constant: false
name: RDH12

http://identifiers.org/biomodels.db/MODEL1310110057#_8628c106_3053_4a06_80bc_eed55d4f93c3
boundary condition: true
initial amount: NaN
is encoded by: hsa:3098
name: HK1
type: Species
is: P19367
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_5cc06ca4_4441_46a4_a51d_65c7ef01b86e
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P43166
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:766
name: CA7
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_c0bc6a9c_538c_414b_b8a6_e7dd1def5729
initial amount: NaN
is encoded by: hsa:4725
boundary condition: true
name: NDUFS5
constant: false
is: SBO:0000252
is: Q6IBA0
initial concentration: NaN
type: Species
has only substance units: false

metaM 3mlda e
name: 3-Methylimidazoleacetic acid
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
is: HMDB02820
is: C05828
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/8122
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false

metaM doco13ecoa c
boundary condition: false
name: 13-docosenoylcoa
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892791
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_6bc87e74_8fac_433a_aaf8_edd9cf209291
initial concentration: NaN
has only substance units: false
name: NT5C2
is encoded by: hsa:22978
boundary condition: true
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
is: P49902

http://identifiers.org/biomodels.db/MODEL1310110057#_5eb515e2_a684_4629_b5e1_9b1b7db7217d
is: SBO:0000252
is: D6RDW3
type: Species
initial amount: NaN
is encoded by: hsa:2982
initial concentration: NaN
name: GUCY1A3
boundary condition: true
has only substance units: false
constant: false

metaR D3AIBTm
reversible: true
type: Reaction
product: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
reactant: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000176

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaR OMPDC
kinetic law: MODEL1310110057#
is described by: ECO:0000269
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.10
is: SBO:0000176
product: MODEL1310110057#
reversible: false
name: orotidine-5'-phosphate decarboxylase
reactant: MODEL1310110057#

metaM 3ddcrn e
boundary condition: false
has only substance units: false
is: HMDB00791
constant: false
type: Species
notes: FORMULA: C19H37NO5 CHARGE: 0
is: C02838
is: SBO:0000247
name: 3-hydroxydodecanoylcarnitine
initial amount: NaN
initial concentration: 1.0

metaR FAOXC8C6m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)m
type: Reaction

metaM m6mpdol L r
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: CHEBI:37635
is: SBO:0000247
type: Species
has only substance units: false
constant: false
notes: FORMULA: C1660H2728N20O520P20 CHARGE: -20

metaM Ser Thr l
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00224
boundary condition: false
notes: FORMULA: XH CHARGE: 0
type: Species
is: SBO:0000247
name: protein-linked serine or threonine residue (O-glycosylation site)
is: CHEBI:58190

http://identifiers.org/biomodels.db/MODEL1310110057#_6e75a429_8f00_4a1b_946c_2bcc8a61c87a
has only substance units: false
constant: false
is encoded by: hsa:80025
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: PANK2
type: Species
is: Q6P1K9

metaR r1259
reactant: MODEL1310110057#
name: EC:6.2.1.3
product: MODEL1310110057#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110057#
is: SBO:0000176
reversible: false

metaR THRASNNaEx
product: MODEL1310110057#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110057#
reversible: false
fast: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
name: L-threonine/L-asparagine Na-dependent exchange (Thr-L in)
reactant: MODEL1310110057#

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

metaM 25aics c
is: CHEBI:58443
is: C04823
has only substance units: false
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
type: Species
initial amount: NaN
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00797
is: SBO:0000247

metaM gbside hs c
initial amount: NaN
type: Species
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
is: SBO:0000247
is: CHEBI:18259
constant: false
name: globoside
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR PI5P3K
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.154
reversible: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
reactant: MODEL1310110057#
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.1.137
modifier: MODEL1310110057#
name: phosphatidylinositol-5-phosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.153
fast: false

metaR FACOAL203
fast: false
product: MODEL1310110057#
reversible: true
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

metaR DNDPt14m
kinetic law: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
name: dUDP transport via dTDP antiport
reversible: false
fast: false
reactant: MODEL1310110057#
is: SBO:0000185
modifier: MODEL1310110057#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR GASNASEly
modifier: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
name: glycosylasparaginase, lysosomal
is version of: http://identifiers.org/ec-code/3.5.1.26
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110057#
is: SBO:0000176
reversible: false
fast: false

metaR GPIDAer
fast: false
modifier: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
reactant: MODEL1310110057#
reversible: false
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
type: Reaction
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_654fb621_7d94_4f96_84c6_cb8eb95ea952
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:217
name: ALDH2
constant: false
boundary condition: true
initial amount: NaN
is: P05091
initial concentration: NaN

metaR EX glyphe LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylphenylalaine
type: Reaction

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_20122d7d_94ec_4996_97da_41a8f718a2ff
is: Q9GZV3
is encoded by: hsa:60482
initial amount: NaN
name: SLC5A7
type: Species
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_fa47fc0a_b121_4876_ba02_52851e07158e
constant: false
is: SBO:0000252
name: NDUFS1
is encoded by: hsa:4719
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: P28331

http://identifiers.org/biomodels.db/MODEL1310110057#_d8df13cc_0061_4a06_bc0d_daf140bd0ad2
is encoded by: hsa:80347
constant: false
is: Q13057
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
name: COASY
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_78d841f4_5907_46ae_aee7_caaca6e00d5f
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8869
name: ST3GAL5
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q9UNP4
type: Species
constant: false

metaR FACOAL204
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
fast: false
modifier: MODEL1310110057#
is: SBO:0000176
product: MODEL1310110057#
name: fatty-acid--CoA ligase
type: Reaction
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_ef88bec4_18c7_411f_84da_65522b9f13b6
boundary condition: true
is: P30048
name: PRDX3
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10935

metaM 3mlda c
is: C05828
has only substance units: false
name: 3-Methylimidazoleacetic acid
boundary condition: false
is: SBO:0000247
is: HMDB02820
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/8122
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
initial amount: NaN
type: Species

metaR ABO4g
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.37
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
is: SBO:0000176
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
type: Reaction
modifier: MODEL1310110057#
reversible: false
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
fast: false

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaR r1686
reactant: MODEL1310110057#
product: MODEL1310110057#
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is: SBO:0000185
fast: false
type: Reaction
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110057#_ea95a39f_c395_4f52_bbcf_78ebcd356ff3
name: MANBA
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4126
constant: false
is: O00462
boundary condition: true
initial concentration: NaN

metaM xylt c
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
type: Species
is: CHEBI:17151
is: SBO:0000247
name: xylitol
has only substance units: false
is: HMDB02917
boundary condition: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_a7fd462c_5d3b_4ad9_a934_694d367d04be
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: _AI972237_1_c
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:AI972237

metaM 3ddcrn c
initial amount: NaN
is: HMDB00623
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C19H37NO5 CHARGE: 0
type: Species
initial concentration: 1.0
name: 3-hydroxydodecanoylcarnitine
constant: false

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaR DDECCRNe
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of lauroyl carnitine into extra cellular space
type: Reaction

metaM HC02207 e
initial amount: NaN
type: Species
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
is: CHEBI:27555
initial concentration: 1.0
name: prostaglandin-c2

http://identifiers.org/biomodels.db/MODEL1310110057#_5fb3f285_5e3c_4c15_b6ee_73a27196ffc4
is: P50226
constant: false
initial concentration: NaN
has only substance units: false
name: SULT1A2
boundary condition: true
is encoded by: hsa:6799
is: SBO:0000252
type: Species
initial amount: NaN

metaM gbside hs e
has only substance units: false
is: CHEBI:18259
constant: false
initial concentration: 1.0
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
is: SBO:0000247
type: Species
name: globoside
initial amount: NaN
boundary condition: false

metaR H2Otly
fast: false
type: Reaction
name: H2O transport, lysosomal
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110057#
reversible: true
kinetic law: MODEL1310110057#

metaR LEUKTRF4t
is: SBO:0000185
name: leukotriene F4 transport
reactant: MODEL1310110057#
reversible: true
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false

metaM 2octpencoa m
name: 2,6,9,12,15-octadecapentenoylcoa
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species

metaM cholcoar x
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:58677
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
constant: false
boundary condition: false
initial amount: NaN
is: HMDB02178
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760

metaM ksi deg35 l
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
initial amount: NaN
name: keratan sulfate I, degradation product 35
is: CHEBI:12936
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: HMDB00143
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_41a354b6_8b36_48a3_812a_5698a3773269
type: Species
initial amount: NaN
has only substance units: false
name: DDC
is: SBO:0000252
initial concentration: NaN
is: Q53Y41
boundary condition: true
is encoded by: hsa:1644
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_749e0517_4f1d_41a1_814b_896bf42c52c6
has only substance units: false
name: MAOB
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
type: Species
is: P27338
is encoded by: hsa:4129
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_cfd4ec7c_ef37_4f24_9bd4_b5772c5c8c1c
is: SBO:0000252
initial concentration: NaN
is: Q9H5J4
type: Species
name: ELOVL6
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:79071

http://identifiers.org/biomodels.db/MODEL1310110057#_073a9a12_0936_4b02_8230_eb39d94f95ac
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
name: _LOC374569_1_e
is encoded by: hsa:LOC374569
has only substance units: false
initial concentration: NaN

metaR FAOXC225C204x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_28c7ada1_2067_4cbf_9a21_b047a6329d8a
is encoded by: hsa:7358
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: O60701
initial amount: NaN
name: UGDH
boundary condition: true

metaR VALTAm
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
product: MODEL1310110057#
reactant: MODEL1310110057#
name: valine transaminase, mitochondiral
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
kinetic law: MODEL1310110057#
reversible: true
modifier: MODEL1310110057#

metaM estradiol r
is: CHEBI:16469
initial amount: NaN
boundary condition: false
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
initial concentration: 1.0
type: Species
has only substance units: false
name: estradiol
constant: false
is: HMDB00151
is: SBO:0000247

metaM mi145p c
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
constant: false
is: SBO:0000247
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
type: Species
is: CHEBI:203600
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB01498

metaM hpdcacrn c
initial concentration: 1.0
initial amount: NaN
constant: false
name: heptadecanoyl carnitine
boundary condition: false
has only substance units: false
is: HMDB06210
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_caf8a638_0e77_4725_9c13_000deede2644
has only substance units: false
type: Species
name: MTMR3
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:8897

http://identifiers.org/biomodels.db/MODEL1310110057#_976ee244_61c0_4acd_b157_61936adac41a
has only substance units: false
type: Species
boundary condition: true
name: PNPLA4
constant: false
is encoded by: hsa:8228
is: P41247
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR EX txa2 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thromboxane A2 exchange
type: Reaction

metaM cysam c
name: cysteaminium
initial concentration: 1.0
constant: false
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
is: CHEBI:58029
type: Species
is: HMDB02991
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM CE1926 e
boundary condition: false
is: SBO:0000247
name: gama-carboxyethyl-hydroxychroman
constant: false
initial concentration: 1.0
is: CHEBI:15748
type: Species
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
initial amount: NaN
is: HMDB00127
has only substance units: false

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaR CYTK1n
reversible: true
is described by: ECO:0000269
type: Reaction
fast: false
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is: SBO:0000176
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP),nuclear
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR r0281
product: MODEL1310110057#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/5.3.1.6
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
reactant: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:

metaM Ser Thr g
is: CHEBI:58336
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: XH CHARGE: 0
is: HMDB00645
has only substance units: false
name: protein-linked serine or threonine residue (O-glycosylation site)
constant: false

metaM xylt e
is: CHEBI:17151
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: HMDB02917
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
name: xylitol

metaR GLUTCOAACBP
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of glutaryl-CoA(5-) from mitochondria into cytosol
type: Reaction

metaR r1252
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110057#
kinetic law: MODEL1310110057#
name: EC:6.2.1.3
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110057#
is: SBO:0000176

metaR ARAB Lt
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
name: L-arabinoase extracellular transport
kinetic law: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
fast: false
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_c95fc25a_fa22_41a4_9f94_c5d61d1cb5d7
boundary condition: true
name: CYP27A1
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q02318
initial amount: NaN
type: Species
is encoded by: hsa:1593

http://identifiers.org/biomodels.db/MODEL1310110057#_10c2bbe2_8c96_4918_8535_1a644e9b8fc0
is: Q9BVK2
initial amount: NaN
name: ALG8
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:79053
type: Species
boundary condition: true

metaM octe5coa x
initial amount: NaN
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: 5-octenoylcoa
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4

metaM i c
name: iodide
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: HMDB12238
is: CHEBI:16382
initial concentration: 1.0
type: Species

metaR BTND1n
is: SBO:0000176
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
reversible: false
type: Reaction
modifier: MODEL1310110057#
name: biotinidase (biotin), nuclear
is version of: http://identifiers.org/ec-code/3.5.1.12
is described by: ECO:0000269

metaM 3hdcoa c
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
is: HMDB00651
is: SBO:0000247
initial concentration: 1.0
type: Species
name: (S)-3-Hydroxydecanoyl-CoA
initial amount: NaN

metaM gbside hs g
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
type: Species
initial concentration: 1.0
is: CHEBI:18259
constant: false
name: globoside
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaR EX fuc L LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Fucose exchange
type: Reaction

metaM gacpail hs c
initial concentration: 1.0
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
is: HMDB01401
initial amount: NaN
is: C00092
type: Species
name: glucosaminyl-acylphosphatidylinositol
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:61548

metaR KSII CORE4tly
fast: false
is: SBO:0000185
name: keratan sulfate II (core 4) transport, extracellular to lysosome
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_e6291cb4_739a_4eb0_b12a_394af5b99f20
is: Q9UNK4
is: SBO:0000252
constant: false
is encoded by: hsa:26279
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
name: PLA2G2D
has only substance units: false

metaM 3dpdhb m
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:50775
name: 3-Decaprenyl-4,5-dihdydroxybenzoate
notes: FORMULA: C57H85O4 CHARGE: -1 INCHI: InChI=1S/C57H86O4/c1-43(2)21-12-22-44(3)23-13-24-45(4)25-14-26-46(5)27-15-28-47(6)29-16-30-48(7)31-17-32-49(8)33-18-34-50(9)35-19-36-51(10)37-20-38-52(11)39-40-53-41-54(57(60)61)42-55(58)56(53)59/h21,23,25,27,29,31,33,35,37,39,41-42,58-59H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,60,61)/b44-23+,45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false

metaM man1p c
is: CHEBI:35374
initial concentration: 1.0
name: D-Mannose 1-phosphate
is: HMDB06330
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
boundary condition: false
is: SBO:0000247
type: Species

metaR UGT1A10r
kinetic law: MODEL1310110057#
reversible: true
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
is: SBO:0000176
is described by: ECO:0000134
type: Reaction
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.17
reactant: MODEL1310110057#
fast: false
product: MODEL1310110057#

metaM dcholcoa x
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: HMDB06292
is: CHEBI:28701
constant: false
initial amount: NaN
is: SBO:0000247
name: chenodeoxycholoyl coenzyme a
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false

metaR r0178
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110057#
type: Reaction
is version of: http://identifiers.org/ec-code/2.5.1.21
reactant: MODEL1310110057#
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
reversible: true
fast: false

metaR GMPtg
fast: false
kinetic law: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110057#
name: GMP transport (Golgi)
reactant: MODEL1310110057#
type: Reaction

metaM thbpt4acam n
type: Species
is: HMDB02281
initial concentration: 1.0
is: SBO:0000247
name: 4a-hydroxytetrahydrobiopterin
initial amount: NaN
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
has only substance units: false
is: CHEBI:15374
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_5bfb9022_6dd0_402e_ac52_940682bad40d
is encoded by: hsa:27124
name: INPP5J
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_89b6fcfb_37f6_4dea_8afb_b6f07a9a7236
is: SBO:0000252
type: Species
name: ALDH3B1
initial amount: NaN
has only substance units: false
is: P43353
boundary condition: true
is encoded by: hsa:221
constant: false
initial concentration: NaN

metaR FADtx
kinetic law: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
name: FAD transporter, peroxisomal
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true

metaR CLFORtex
reactant: MODEL1310110057#
type: Reaction
is described by: ECO:0000304
reversible: false
modifier: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000185
name: chloride transport via formate countertransport
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
kinetic law: MODEL1310110057#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_7997167a_1e2d_48ba_af3e_464c526c7f2a
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI935189
type: Species
has only substance units: false
boundary condition: true
name: _AI935189_1_m
constant: false
initial concentration: NaN

metaR DOCO13EFATP
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: absorption or uptake of 13-docosenoic acid into cells
type: Reaction

metaR TETDECE1CRNe
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tetradecenoyl carnitine into extra cellular space
type: Reaction

metaR NAtx
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
fast: false
product: MODEL1310110057#
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000185
name: sodium transport via diffusion (perioxisome)
is described by: ECO:0000000

metaM andrstandn r
is: CHEBI:15994
initial amount: NaN
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
name: 5alpha-androstane-3,17-dione
is: SBO:0000247
is: HMDB00899
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_a43d43ef_b158_4756_a594_91048799c95a
constant: false
has only substance units: false
type: Species
is: P49915
is encoded by: hsa:8833
name: GMPS
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR ELAIDCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
is: SBO:0000176
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
name: carnitine O-palmitoyltransferase
product: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110057#_8adf5fae_9a67_40b7_92a6_5d167e615aa2
is encoded by: hsa:4712
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
name: NDUFB6
is: Q5VYT2
is: SBO:0000252
has only substance units: false

metaM 3mldz c
initial amount: NaN
notes: FORMULA: C6H8N2O CHARGE: 0 INCHI: InChI=1S/C6H8N2O/c1-8-4-6(2-3-9)7-5-8/h3-5H,2H2,1H3 EHMN_ABBREVIATION: C05827
is: SBO:0000247
is: HMDB04181
type: Species
name: 1-methylimidazole-4-acetaldehyde
constant: false
is: CHEBI:28104
boundary condition: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_431973d6_d32d_40a0_b093_f2519b90c3d1
type: Species
name: SLC7A6
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9057
constant: false
is: Q92536
boundary condition: true
has only substance units: false

metaM nh4 e
initial concentration: 1.0
name: ammonium
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00051
is: CHEBI:28938
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
boundary condition: false

metaR FAOXC184x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:4)x
type: Reaction

metaR SIAASEly
is version of: http://identifiers.org/ec-code/3.2.1.18
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
product: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110057#
fast: false

metaR DOPAtu
name: Dopamine uniport
type: Reaction
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

metaM i e
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: HMDB12238
is: CHEBI:16382
constant: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
boundary condition: false
name: iodide

metaR r1584
fast: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaR ELAIDCPT2
name: carnitine transferase
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000000
reactant: MODEL1310110057#
is: SBO:0000176
modifier: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR EX 3tdcrn
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-tetradecanoyl carnitine
type: Reaction

metaM 4fumacac c
type: Species
is: HMDB01268
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:18034
name: 4-fumarylacetoacetate(2-)
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
has only substance units: false

metaM undcoa m
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: undecanoylcoa
has only substance units: false
constant: false
notes: FORMULA: C32H52N7O17P3S CHARGE: -4
is: HMDB13114
initial amount: NaN

metaM atp e
initial concentration: 1.0
name: ATP(4-)
is: CHEBI:57299
has only substance units: false
is: SBO:0000247
is: HMDB00538
type: Species
is: C00002
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_2a5a5591_0d87_4273_87d5_301684c4629d
initial concentration: NaN
constant: false
type: Species
is: P03905
is: SBO:0000252
is encoded by: hsa:4538
boundary condition: true
initial amount: NaN
has only substance units: false
name: ND4

metaR DNDPt25m
product: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction
name: dTDP transport via dCDP antiport
reactant: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110057#
is described by: ECO:0000269
reversible: false
is: SBO:0000185

metaM lnlncg l
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
constant: false
type: Species
is: CHEBI:32391
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: gamma-linolenate
has only substance units: false
is: HMDB03073

http://identifiers.org/biomodels.db/MODEL1310110057#_bc0f9d20_5f94_428f_991e_02a6fbf2d72d
boundary condition: true
is encoded by: hsa:6533
initial concentration: NaN
is: Q9BRI2
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
name: SLC6A6

metaM prgnlones c
name: pregnenolone sulfate
notes: FORMULA: C21H31O5S CHARGE: -1 INCHI: InChI=1S/C21H32O5S/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19H,5-12H2,1-3H3,(H,23,24,25)/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: CE4764
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:35420
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00774
is: SBO:0000247

metaR r1583
is: SBO:0000185
type: Reaction
product: MODEL1310110057#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_2115ef56_9e51_4570_b568_f4d12a8b7f9a
boundary condition: true
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: GPX1
is encoded by: hsa:2876

metaR FAOXC102C101x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_229e4eab_c479_479f_b001_57f01007e68e
is encoded by: hsa:316
is: Q06278
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
name: AOX1
constant: false

metaR GLCAASE8ly
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110057#
is described by: ECO:0000269
name: beta-glucuronidase, lysosomal
fast: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.31
modifier: MODEL1310110057#
product: MODEL1310110057#
reversible: false

metaM ksi pre33 g
is: CHEBI:58053
constant: false
is: HMDB00175
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 33
is: C00130
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
type: Species
initial concentration: 1.0

metaR CORE2GTg
modifier: MODEL1310110057#
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.102
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110057#
reversible: false
reactant: MODEL1310110057#
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110057#_ee2d2f7d_74af_42a0_8bde_cf8fa15690f8
initial amount: NaN
boundary condition: true
constant: false
name: GART
is encoded by: hsa:2618
initial concentration: NaN
type: Species
is: P22102
has only substance units: false
is: SBO:0000252

metaR MACACI
type: Reaction
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.5.1.18
name: maleylacetoacetate isomerase
is: SBO:0000176
reversible: false
modifier: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
reactant: MODEL1310110057#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110057#_ba22f683_4de2_42a7_8a9c_6c20657ac836
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:81579
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q542Y6
boundary condition: true
name: PLA2G12A

metaM 3ddecdicoa x
has only substance units: false
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial concentration: 1.0
constant: false
is: HMDB03952
name: 3,6-dodecadienoylcoa
type: Species
is: SBO:0000247
is: C05280
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_a31666a9_02ef_4bb9_9a4a_4b65c3aa746e
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is: Q96AT9
name: RPE
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6120

metaR FAOXC225C204m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaR r1586
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#

metaR r0173
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: true
type: Reaction
name: (S)-Lactate:NAD+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.1.1.27
notes: GENE_ASSOCIATION: (3704.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:12042361,PMID:17045662,PMID:7449128,PMID:9927705 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.19

http://identifiers.org/biomodels.db/MODEL1310110057#_cd775234_b81b_4b0e_8fe3_84947972eaa5
is: Q9BQL0
is encoded by: hsa:594
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
name: BCKDHB
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_efcd6233_e105_4a59_b30d_41ef9fbabf52
type: Species
name: SLC10A1
initial concentration: NaN
constant: false
is encoded by: hsa:6554
is: B2RA41
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR r1799
reversible: false
product: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110057#
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_b1c3b750_e9fb_4506_a376_32ec15cda153
is encoded by: hsa:2954
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: GSTZ1
boundary condition: true
type: Species
constant: false
is: SBO:0000252

metaM gbside hs l
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
has only substance units: false
is: SBO:0000247
is: CHEBI:18259
boundary condition: false
initial amount: NaN
type: Species
name: globoside
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_21761107_d4f8_47d4_8a78_be109567962c
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:123041
initial concentration: NaN
type: Species
name: SLC24A4
boundary condition: true

metaM succoa x
boundary condition: false
initial concentration: 1.0
name: Succinyl-CoA
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
is: HMDB01022
type: Species
constant: false

metaM cholcoar r
is: SBO:0000247
type: Species
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
is: CHEBI:58677
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: HMDB02178
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
initial concentration: 1.0

metaR ECOAH9m
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
kinetic law: MODEL1310110057#
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
modifier: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM atp c
initial amount: NaN
constant: false
name: ATP(4-)
initial concentration: 1.0
has only substance units: false
is: CHEBI:30616
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00538
is: C00002

metaR r1892
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reversible: false
is: SBO:0000185
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM HC01403 m
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28325
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
name: (S)-Hydroxydecanoyl-CoA
type: Species
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false

metaR r2069
product: MODEL1310110057#
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR r0287
is described by: ECO:0000000
is: SBO:0000176
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
type: Reaction
reversible: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
kinetic law: MODEL1310110057#
fast: false
product: MODEL1310110057#
modifier: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_68e5c647_b569_4dd9_a674_6c56ebc89e48
initial amount: NaN
is encoded by: hsa:230
name: ALDOC
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: P09972
type: Species
is: SBO:0000252

metaR SUBERCROT
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberyl carnitine
type: Reaction

metaR r1585
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaM txa2 e
boundary condition: false
constant: false
has only substance units: false
name: thromboxane A2(1-)
initial amount: NaN
is: CHEBI:57445
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: SBO:0000247
is: HMDB01452
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_2e9dbef4_a56a_4a63_a8ca_61cf25a25c27
boundary condition: true
constant: false
type: Species
is encoded by: hsa:NM 001929
is: SBO:0000252
initial concentration: NaN
name: _NM_001929_1_c
has only substance units: false
initial amount: NaN

metaR TTDCAFATPc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaR P5CRm
is: SBO:0000176
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000304
name: pyrroline-5-carboxylate reductase (m)
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.2
reactant: MODEL1310110057#
reversible: false
product: MODEL1310110057#

metaM lnlncg r
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: gamma-linolenate
is: CHEBI:32391
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: SBO:0000247
has only substance units: false
is: HMDB03073
boundary condition: false

metaR FAOXC205C184x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:4)x
type: Reaction

metaR r2391
kinetic law: MODEL1310110057#
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000185

metaR S6T18g
fast: false
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.2.17
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.21
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#

metaM dolp L r
constant: false
name: dolichyl phosphate(2-)
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: SBO:0000247
boundary condition: false
is: CHEBI:57683

metaR SIAT4Bg
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.4
type: Reaction
product: MODEL1310110057#
modifier: MODEL1310110057#
fast: false
is described by: ECO:0000269
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
is: SBO:0000176

metaR FACOAL205
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110057#
reversible: true
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110057#
is: SBO:0000176
fast: false

metaM nrvnc c
is: CHEBI:32392
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
name: nervonate
is: HMDB02368

metaR r1580
product: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110057#

metaR COUCOAFm
name: p-coumaroyl-CoA formation
reversible: false
reactant: MODEL1310110057#
fast: false
product: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: 6.2.1.12 Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine. (EC 6.2.1.12) .
type: Reaction

metaM ptth m
type: Species
initial amount: NaN
name: pantetheine
constant: false
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
initial concentration: 1.0
is: HMDB03426
has only substance units: false
is: CHEBI:16753
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_c6aef711_fdfa_4d14_b1cb_905ea9ea129e
is encoded by: hsa:1633
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
name: DCK
is: P27707
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_8cfb6f31_1010_47e4_89d5_4da7a3217d7c
has only substance units: false
is encoded by: hsa:5172
is: SBO:0000252
is: O43511
initial concentration: NaN
boundary condition: true
type: Species
constant: false
initial amount: NaN
name: SLC26A4

metaR FAOXC101x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_ca4be59b_da0c_4504_8f54_74cfadd132cf
name: ADCY3
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is: B3KT86
is encoded by: hsa:109
has only substance units: false
initial amount: NaN
type: Species

metaR PAIL45P HStn
kinetic law: MODEL1310110057#
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110057#_4af078f2_299e_4c26_ae29_b240fdff8f0c
boundary condition: true
is encoded by: hsa:30
is: SBO:0000252
name: ACAA1
is: Q96CA6
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaM nrvnc e
is: CHEBI:32392
initial concentration: 1.0
type: Species
initial amount: NaN
name: nervonate
has only substance units: false
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
boundary condition: false
constant: false
is: HMDB02368
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_c2d54548_cd3b_48e8_b8ed_aad4a9e9efd1
is: P14618
constant: false
is encoded by: hsa:5315
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
name: PKM2
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_7e9e8ecb_e5c3_43e7_bfd3_b4cbc6853314
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:55825
is: Q9BY49
name: PECR
has only substance units: false
initial amount: NaN

metaR DADNt4
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reversible: true
reactant: MODEL1310110057#
type: Reaction
fast: false
name: deoxyadenosine transport via diffusion
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000000

metaR ME1m
type: Reaction
product: MODEL1310110057#
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.1.1.38
fast: false
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reversible: false
name: malic enzyme (NAD), mitochondrial
modifier: MODEL1310110057#
is: SBO:0000176
kinetic law: MODEL1310110057#

metaR FAOXC226m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

metaR 3AIBtm
is described by: ECO:0000000
reactant: MODEL1310110057#
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000185
name: 3-amino-isobutyrate transport, mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
fast: false
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.6.1.19

metaR FACOAL206
product: MODEL1310110057#
reversible: true
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
reactant: MODEL1310110057#
is described by: ECO:0000269

metaR HPYRR2x
is described by: ECO:0000304
kinetic law: MODEL1310110057#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.27
reactant: MODEL1310110057#
name: hydroxypyruvate reductase (NADH)
type: Reaction
product: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3948.1) or (197257.1) or (3945.1) or (160287.1) or (3945.1 and 3939.1) or (92483.1) or (3939.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:14635115,PMID:5635456 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.2.4
modifier: MODEL1310110057#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_7546b635_2971_42a2_ab15_5209d4fb5919
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
name: ACADM
is: P11310
is: SBO:0000252
is encoded by: hsa:34
type: Species

metaR DGSNtm
reversible: true
kinetic law: MODEL1310110057#
fast: false
name: deoyguanosine transport in mitochondria
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:3696164 NOTES:
is described by: ECO:0000000
product: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction

metaM txa2 c
is: HMDB01452
name: thromboxane A2(1-)
is: CHEBI:57445
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
constant: false

metaM nh4 c
boundary condition: false
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
type: Species
initial amount: NaN
is: C01342
has only substance units: false
is: HMDB00051
is: CHEBI:28938
initial concentration: 1.0
constant: false
name: Ammonium

http://identifiers.org/biomodels.db/MODEL1310110057#_14fbe6a3_ad3e_4876_9805_be88e51bfb41
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: SLC23A1
has only substance units: false
is encoded by: hsa:9963

http://identifiers.org/biomodels.db/MODEL1310110057#_594467d2_ec55_4790_ac0b_404e3d1c0676
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: H6PD
initial amount: NaN
is encoded by: hsa:9563
type: Species
boundary condition: true
is: O95479

metaM HC01603 c
constant: false
is: SBO:0000247
name: 10-Formyltetrahydrofolate
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0
is: C00234
is: CHEBI:57454
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false

metaM ksi deg30 l
is: CHEBI:12936
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
name: keratan sulfate I, degradation product 30
has only substance units: false
is: HMDB00143
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
constant: false
is: SBO:0000247

metaM 12ppd R c
type: Species
is: HMDB01881
has only substance units: false
name: (R)-propane-1,2-diol
is: SBO:0000247
constant: false
is: CHEBI:28972
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM ocdececrn m
initial amount: NaN
constant: false
name: 11-octadecenoyl carnitine
is: HMDB06351
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C25H47NO4 CHARGE: 0
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_97f77169_999e_43b1_b11c_6fc2f288f727
type: Species
initial concentration: NaN
boundary condition: true
is: P22413
constant: false
is: SBO:0000252
has only substance units: false
name: ENPP1
initial amount: NaN
is encoded by: hsa:5167

http://identifiers.org/biomodels.db/MODEL1310110057#_180636b7_8784_4b0d_ac24_41580a28ba9c
boundary condition: true
name: PIK3CB
has only substance units: false
initial amount: NaN
type: Species
is: B4DER4
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:5291

metaM his L m
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:15971
boundary condition: false
is: SBO:0000247
name: L-histidine
initial amount: NaN
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: HMDB00177

http://identifiers.org/biomodels.db/MODEL1310110057#_c4a34000_4095_4ebe_aecd_2836ec928928
boundary condition: true
is: SBO:0000297
initial concentration: NaN
name: NME1:NME2
constant: false
is encoded by: hsa:4830
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_7a4da79f_ea19_4f26_aa14_a16b9dfda18c
has only substance units: false
initial amount: NaN
is encoded by: hsa:8396
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
name: PIP4K2B
is: P78356
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_8ce4b536_f675_4b55_82a5_6067b6c0c177
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6389
initial concentration: NaN
name: SDHA
is: P31040
type: Species
initial amount: NaN
boundary condition: true

metaR r2390
product: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110057#
reversible: false
reactant: MODEL1310110057#

metaR r1581
type: Reaction
reactant: MODEL1310110057#
is: SBO:0000185
product: MODEL1310110057#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_5d4465a9_89f0_41e0_9a14_8822edb9bf06
name: BDH1
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:622

metaR r0170
is version of: http://identifiers.org/ec-code/2.7.1.40
fast: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
modifier: MODEL1310110057#
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
reversible: true
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_99c6b00d_28b0_43fa_acdf_78baa40c9691
constant: false
name: NDUFA3
is encoded by: hsa:4696
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is: O95167

metaM octe5coa m
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
type: Species
has only substance units: false
boundary condition: false
constant: false
name: 5-octenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110057#_045194c0_fd6b_4597_85f8_5dd78d8079d3
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:BE966236
initial concentration: NaN
type: Species
name: _BE966236_1_m

http://identifiers.org/biomodels.db/MODEL1310110057#_d98982b7_eea4_4c83_a0c3_62db673e2d38
has part: O95498
has only substance units: false
name: VNN3:VNN2:VNN1
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:55350
is: SBO:0000297
type: Species
constant: false
is encoded by: hsa:8875
boundary condition: true

metaM ksii core4 pre6 g
constant: false
notes: FORMULA: C69H111N6O51SX CHARGE: -2
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:28067
boundary condition: false
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 6
has only substance units: false

metaR r1589
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR DESAT16 2
type: Reaction
name: palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA)
modifier: MODEL1310110057#
reversible: false
is version of: http://identifiers.org/ec-code/1.14.19.1
is: SBO:0000176
product: MODEL1310110057#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_d363b198_c627_4473_8f54_a3e33f0fef23
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:122970
is: Q8N9L9
type: Species
boundary condition: true
constant: false
initial amount: NaN
name: ACOT4

http://identifiers.org/biomodels.db/MODEL1310110057#_3cae8148_aca9_404d_85df_efba9675d594
initial amount: NaN
type: Species
name: RHAG
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6005
is: Q96E98
constant: false

metaR r1109
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110057#
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110057#
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_497edaa7_d89c_41a9_b2a0_adcb87858c52
name: NDUFA9
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
constant: false
is: Q16795
is encoded by: hsa:4704
initial concentration: NaN
initial amount: NaN

metaR RE2660C
reversible: true
is described by: ECO:0000000
name: RE2660
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
product: MODEL1310110057#
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaR RE2626M
product: MODEL1310110057#
is: SBO:0000176
modifier: MODEL1310110057#
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
name: RE2626
reversible: true
fast: false
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#

metaR r2386
fast: false
reactant: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
product: MODEL1310110057#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaM c6dc c
type: Species
is: SBO:0000247
is: HMDB00705
name: adipoyl carnitine
notes: FORMULA: C13H22NO6 CHARGE: -1
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_78b01b80_58e1_4788_abb0_777fd492e534
has only substance units: false
is encoded by: hsa:79369
type: Species
name: B3GNT4
boundary condition: true
initial concentration: NaN
constant: false
is: Q9C0J1
is: SBO:0000252
initial amount: NaN

metaM dcamp c
type: Species
is: CHEBI:57567
constant: false
boundary condition: false
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
is: HMDB00536
name: N6-(1,2-Dicarboxyethyl)-AMP
is: SBO:0000247
initial amount: NaN
is: C03794
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_76342d9c_0082_417c_b5b0_628c5399ffff
is: SBO:0000252
type: Species
name: PDE4B
has only substance units: false
is encoded by: hsa:5142
is: Q5TEK5
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_6a4f7c1b_ef72_4f1c_ad44_7aa28349690f
is encoded by: hsa:9962
constant: false
type: Species
has only substance units: false
name: SLC23A2
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_d1158b49_2837_4185_af71_6c44e7f387cc
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
name: _U37519_1_m
type: Species
initial concentration: NaN
is encoded by: hsa:U37519
boundary condition: true

metaR SMPD3g
is described by: ECO:0000304
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.12
modifier: MODEL1310110057#
reversible: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000176

metaM pacald c
constant: false
type: Species
is: HMDB06236
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
is: CHEBI:16424
has only substance units: false
name: phenylacetaldehyde

http://identifiers.org/biomodels.db/MODEL1310110057#_bc39dc6c_a8b8_44a0_9109_3eb3e0367b59
has only substance units: false
type: Species
is: Q1LZ56
initial concentration: NaN
initial amount: NaN
name: SLC36A1
boundary condition: true
constant: false
is encoded by: hsa:206358
is: SBO:0000252

metaR ACOAD10m
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110057#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
product: MODEL1310110057#
modifier: MODEL1310110057#
reactant: MODEL1310110057#
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM

metaR r2385
product: MODEL1310110057#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
modifier: MODEL1310110057#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
kinetic law: MODEL1310110057#
type: Reaction

metaM arab L c
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:30849
notes: FORMULA: C5H10O5 CHARGE: 0
has only substance units: false
is: HMDB00646
initial amount: NaN
name: L-arabinose
is: SBO:0000247
boundary condition: false

metaR TDCHOLAtx
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
fast: false
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_5482036d_85ba_44c3_b939_c936d5cec674
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: GALK2
initial amount: NaN
is encoded by: hsa:2585

http://identifiers.org/biomodels.db/MODEL1310110057#_e81469f5_348a_41e0_9b3c_feb6ee70a54f
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
name: DPM2
is encoded by: hsa:8818
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_40b66d36_6ef2_4149_b952_c0bd774a6b34
initial amount: NaN
initial concentration: NaN
name: GLRX2
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is encoded by: hsa:51022

http://identifiers.org/biomodels.db/MODEL1310110057#_9bad8ada_1220_47bb_aaa6_c2d5159f7348
is: Q92569
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: PIK3R3
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:8503

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_8d04d72a_36bf_4eae_90ea_c416b22e78cf
has only substance units: false
type: Species
is: Q8NCI4
constant: false
boundary condition: true
is encoded by: hsa:54872
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: PIGG

metaM gdp m
is: C00035
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
name: GDP
is: HMDB01201
is: CHEBI:58189
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_380968ef_c8d6_4e7b_8fe2_4d520052c63f
is: SBO:0000252
initial concentration: NaN
is: P49753
name: ACOT2
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:10965
type: Species
constant: false

metaR A4GALTg
modifier: MODEL1310110057#
name: Lactosylceramide 4-alpha-galactosyltransferase
reactant: MODEL1310110057#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
is version of: http://identifiers.org/ec-code/2.4.1.228
kinetic law: MODEL1310110057#
type: Reaction
reversible: false
fast: false
is: SBO:0000176
product: MODEL1310110057#

metaM C02470 c
has only substance units: false
initial amount: NaN
is: HMDB00881
type: Species
name: Xanthurenic acid
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
is: C02470
is: http://identifiers.org/pubchem.compound/5485
constant: false

metaR RE1807C
reactant: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000000
name: RE1807
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
kinetic law: MODEL1310110057#
is: SBO:0000176
reversible: true
type: Reaction

metaM arg L m
type: Species
has only substance units: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: CHEBI:32682
boundary condition: false
constant: false
is: HMDB00517
initial concentration: 1.0
name: L-argininium(1+)
initial amount: NaN
is: SBO:0000247

metaR r2388
modifier: MODEL1310110057#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185

metaR UDPGD
reversible: false
is described by: ECO:0000304
product: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (7358.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 1.1.1.22 Confidence Level: 2 AUTHORS: PMID:9296457,PMID:9737970 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.1.1.22
modifier: MODEL1310110057#
type: Reaction
name: UDPglucose 6-dehydrogenase
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000176

metaR ADKd
name: adenylate kinase (d form)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
reactant: MODEL1310110057#
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: true
modifier: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_942f1b30_169b_4bba_9b2a_23952fa14a67
constant: false
initial amount: NaN
is encoded by: hsa:1718
name: DHCR24
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q15392
boundary condition: true
has only substance units: false

metaR r2099
type: Reaction
fast: false
reversible: true
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110057#
is described by: ECO:0000000
modifier: MODEL1310110057#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_d56e8649_387c_494e_bde6_f7691360a5fe
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:641371
is: SBO:0000252
has only substance units: false
name: ACOT1
constant: false
is: E9KL42
type: Species
boundary condition: true

metaR r1587
type: Reaction
is: SBO:0000185
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110057#
is described by: ECO:0000000
product: MODEL1310110057#

metaR TRPt
type: Reaction
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000185
fast: false
product: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
reactant: MODEL1310110057#
is described by: ECO:0000269
name: L-tryptophan transport

metaR MTHFR3
notes: GENE_ASSOCIATION: (4524.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 2 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 350. NOTES:absorbed folate undergoes conversion to 5-methyl-THF within the enterocytes.
reversible: false
product: MODEL1310110057#
name: 5,10-methylenetetrahydrofolatereductase (NADPH)
modifier: MODEL1310110057#
is: SBO:0000176
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.5.1.20
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_89c56eb2_5076_4b21_94e8_6e62e1829b9a
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI971036
has only substance units: false
initial amount: NaN
name: _AI971036_1_x
boundary condition: true
constant: false
type: Species

metaR r2387
product: MODEL1310110057#
is described by: ECO:0000000
reactant: MODEL1310110057#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
modifier: MODEL1310110057#
reversible: false
kinetic law: MODEL1310110057#

metaR GALASE7ly
fast: false
name: beta-galactosidase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110057#
modifier: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaM odecoa m
is: SBO:0000247
is: HMDB01322
initial amount: NaN
constant: false
has only substance units: false
name: Octadecenoyl-CoA (n-C18:1CoA)
is: CHEBI:57387
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510

http://identifiers.org/biomodels.db/MODEL1310110057#_7da91350_cdaf_4222_8850_57cc4cbbcde6
boundary condition: true
name: SLC24A1
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is: B4DUG1
initial concentration: NaN
is encoded by: hsa:9187

metaR r1588
reversible: true
product: MODEL1310110057#
is: SBO:0000185
reactant: MODEL1310110057#
is described by: ECO:0000000
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r2098
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110057#
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110057#
fast: false
is described by: ECO:0000000
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_070ec3bb_7cd1_4272_bd50_7e1f9e5aa8b9
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:30
constant: false
has only substance units: false
boundary condition: true
name: ACAA1
is: Q96CA6

metaM gluala e
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
is: HMDB06248
constant: false
boundary condition: false
is: C03740
is: http://identifiers.org/pubchem.compound/6503
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: 5-L-Glutamyl-L-alanine
type: Species
initial concentration: 1.0

metaM dhf c
initial concentration: 1.0
constant: false
name: 7,8-Dihydrofolate
is: HMDB01056
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
has only substance units: false
is: C00415
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:57451

http://identifiers.org/biomodels.db/MODEL1310110057#_f51c714a_3ea8_4e57_916f_23a8bc24531b
name: COX6A2
initial amount: NaN
constant: false
is: Q02221
is encoded by: hsa:1339
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_7e25490c_4449_44d3_b90e_8b1252b17e1d
type: Species
constant: false
is: SBO:0000252
has only substance units: false
name: IDH3B
boundary condition: true
initial amount: NaN
is encoded by: hsa:3420
is: O43837
initial concentration: NaN

metaR HSD3A1r
reactant: MODEL1310110057#
modifier: MODEL1310110057#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.225
is described by: ECO:0000269
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is: SBO:0000176
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
product: MODEL1310110057#
fast: false

metaM em2emgacpail hs r
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
initial amount: NaN
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16038
boundary condition: false
has only substance units: false

metaR HXPRT
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.2.8
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
fast: false
reactant: MODEL1310110057#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
reversible: false
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)

metaR S6T2g
reactant: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
product: MODEL1310110057#
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000176

metaR r2382
type: Reaction
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110057#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
product: MODEL1310110057#
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#

metaR AK2LGCHOLt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.1.1.21 Confidence Level: 2 AUTHORS: PMID:2004782,PMID:2253271,PMID:8106516 NOTES:
fast: false
name: 1-alkyl 2-acylglycerol 3-phosphocholine transport
reversible: true
type: Reaction
product: MODEL1310110057#
is described by: ECO:0000269
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_eb7c1145_95cb_4cff_ba6a_5d3cb015bf03
initial amount: NaN
is: SBO:0000252
is: P49448
boundary condition: true
initial concentration: NaN
name: GLUD2
type: Species
constant: false
has only substance units: false
is encoded by: hsa:2747

metaM cdpea c
constant: false
name: cdpea[c]
is: CHEBI:57876
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
is: HMDB01564
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C11H19N4O11P2 CHARGE: -1 INCHI: InChI=1S/C11H20N4O11P2/c12-2-4-23-27(19,20)26-28(21,22)24-5-6-8(16)9(17)10(25-6)15-3-1-7(13)14-11(15)18/h1,3,6,8-10,16-17H,2,4-5,12H2,(H,19,20)(H,21,22)(H2,13,14,18)/p-1/t6-,8-,9-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00433 EHMN_ABBREVIATION: C00570

metaM tyr L m
initial concentration: 1.0
name: L-tyrosine
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: SBO:0000247
initial amount: NaN
is: HMDB00158
boundary condition: false
constant: false
type: Species
is: CHEBI:17895
has only substance units: false

metaR GUAPRT
name: guanine phosphoribosyltransferase
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
reactant: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.2.8
fast: false
reversible: false

metaM dag hs e
name: diglyceride
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:18035
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110057#_23e9aed8_9397_418d_be11_035d7f21ecd9
type: Species
has part: P39656
constant: false
has part: Q53G02
name: DAD1:DDOST:RPN1:RPN2
has part: P04844
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6185
is encoded by: hsa:6184
boundary condition: true
is: SBO:0000297
has only substance units: false
has part: P04843
is encoded by: hsa:1650
is encoded by: hsa:1603

metaR r2097
product: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110057#
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM hpdcacrn m
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
is: HMDB06210
name: heptadecanoyl carnitine
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
boundary condition: false

metaM HC02180 c
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
constant: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: thromboxane-b2
is: CHEBI:28728
initial amount: NaN

metaR PEAMNO
product: MODEL1310110057#
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.22
type: Reaction
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.4.3.21
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.4.3.4
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
is: SBO:0000176
name: Phenethylamine oxidase
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_407168f0_43ba_49d4_8d80_952e52a706b6
name: SDHB
initial amount: NaN
type: Species
is: P21912
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:6390

http://identifiers.org/biomodels.db/MODEL1310110057#_be2a0fc0_a7e1_473c_b93a_d438ce20fc3b
is encoded by: hsa:594
boundary condition: true
type: Species
name: BCKDHB
constant: false
initial concentration: NaN
has only substance units: false
is: P21953
is: SBO:0000252
initial amount: NaN

metaM gdp n
initial amount: NaN
is: HMDB01201
type: Species
has only substance units: false
is: CHEBI:58189
constant: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: GDP(3-)

metaR ADSL2
product: MODEL1310110057#
reversible: false
is version of: http://identifiers.org/ec-code/4.3.2.2
modifier: MODEL1310110057#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
type: Reaction
reactant: MODEL1310110057#
name: adenylosuccinate lyase
fast: false

metaR PIACGT
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.198
is version of: http://identifiers.org/ec-code/2.4.1.83
reactant: MODEL1310110057#
name: phosphatidylinositol N-acetylglucosaminyltransferase
fast: false
type: Reaction
product: MODEL1310110057#
reversible: false
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_8bce114b_c24c_4822_9a40_ab3b8a3d03cc
name: SULT1A2
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:6799
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR SUCCACT
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of succinate
type: Reaction

metaM pro L c
initial amount: NaN
name: L-proline
is: SBO:0000247
type: Species
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:17203
is: HMDB00162
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145

metaR FAOXC143C123x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)x
type: Reaction

metaR r2096
kinetic law: MODEL1310110057#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110057#
modifier: MODEL1310110057#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110057#

metaR r1106
reactant: MODEL1310110057#
name: Postulated transport reaction
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_fa4419ce_4e2b_406f_883b_fd8bfb577f4b
is: A8K761
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: NDUFB10
is encoded by: hsa:4716

metaR C8DCc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberylcarnitine
type: Reaction

metaM dhf e
initial concentration: 1.0
type: Species
has only substance units: false
name: dihydrofolate(2-)
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: CHEBI:57451
is: SBO:0000247
is: HMDB01056

metaR FAOXC61C4x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)x
type: Reaction

metaM dag hs c
name: diglyceride
type: Species
initial concentration: 1.0
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
is: CHEBI:18035
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false

metaM ksi pre34 g
constant: false
boundary condition: false
is: CHEBI:58053
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C00130
name: keratan sulfate I biosynthesis, precursor 34
is: HMDB00175
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
has only substance units: false

metaR ADSL1
product: MODEL1310110057#
reversible: false
type: Reaction
name: adenylosuccinate lyase
kinetic law: MODEL1310110057#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.3.2.2
modifier: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
is: SBO:0000176

metaR URIt
modifier: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110057#
is described by: ECO:0000269
reversible: true
product: MODEL1310110057#
reactant: MODEL1310110057#
name: uridine facilated transport in cytosol
is: SBO:0000185
fast: false

metaM acgam1p c
is: CHEBI:7125
boundary condition: false
name: N-Acetyl-D-glucosamine 1-phosphate
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
is: HMDB01367
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaR r2384
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
reactant: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110057#
reversible: false
modifier: MODEL1310110057#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110057#
type: Reaction

metaR r2095
is: SBO:0000185
kinetic law: MODEL1310110057#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110057#
modifier: MODEL1310110057#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110057#

metaR UMPK4n
name: UMP kinase (GTP),nuclear
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110057#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
product: MODEL1310110057#

metaR RE3269C
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
name: RE3269
fast: false
kinetic law: MODEL1310110057#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.48
reactant: MODEL1310110057#
modifier: MODEL1310110057#
product: MODEL1310110057#
reversible: true

metaM arachdcrn c
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: CHEBI:57387
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB01322
is: SBO:0000247
name: C20:4 carnitine
boundary condition: false
type: Species

metaM HC02180 e
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: thromboxane-b2
is: CHEBI:28728
constant: false

metaR CMPACNAtn
fast: false
type: Reaction
reversible: false
product: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110057#
is: SBO:0000185
name: CMP-Sia nuclear export

metaR EX estradiol LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: estradiol exchange
type: Reaction

metaR B3GALT5g
fast: false
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
product: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: false
name: Beta-1,3-galactosyltransferase 5

metaM arab L e
boundary condition: false
is: CHEBI:30849
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0
is: HMDB00646
has only substance units: false
name: L-arabinose
type: Species
is: SBO:0000247
constant: false

metaR FAOXC184C163x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:3)x
type: Reaction

metaR r2094
is described by: ECO:0000000
reactant: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110057#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM pro L e
boundary condition: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: CHEBI:17203
is: HMDB00162
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
name: L-proline
initial amount: NaN

metaM nadph x
name: Nicotinamide adenine dinucleotide phosphate - reduced
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
constant: false
type: Species
boundary condition: false
is: C00005
has only substance units: false
initial amount: NaN
is: CHEBI:57783
is: SBO:0000247
is: HMDB00221
initial concentration: 1.0

metaR HSD17B42x
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: false
product: MODEL1310110057#
name: hydroxysteroid (17-beta) dehydrogenase 4
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
is described by: ECO:0000269
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110057#_85ee0285_65d1_424d_8da4_aaa8e7bea455
initial amount: NaN
initial concentration: NaN
name: ATP2B1
constant: false
is: SBO:0000252
boundary condition: true
type: Species
is: P20020
has only substance units: false
is encoded by: hsa:490

metaR r2093
reactant: MODEL1310110057#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110057#
modifier: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110057#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_9d6da6c3_78f3_4ac5_b5bf_f468100746ff
is: SBO:0000252
name: TPK1
has only substance units: false
is: F5GZG6
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:27010
boundary condition: true
type: Species
constant: false

metaR CMPACNAtg
is: SBO:0000185
modifier: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
reactant: MODEL1310110057#
reversible: true
fast: false
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000269
name: CMP-Sia Golgi transport via CMP antiport

http://identifiers.org/biomodels.db/MODEL1310110057#_29570279_b334_4cd2_9301_a767380be5d8
is encoded by: hsa:6576
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: SLC25A1
constant: false
boundary condition: true
initial concentration: NaN
is: D9HTE9

http://identifiers.org/biomodels.db/MODEL1310110057#_eac25662_e394_49e2_a33b_011cefcc0332
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:9377
is: SBO:0000252
is: P20674
name: COX5A
initial amount: NaN
has only substance units: false

metaR NH4t3r
type: Reaction
name: ammonia transport via proton antiport
is: SBO:0000185
fast: false
product: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
kinetic law: MODEL1310110057#
reversible: true
modifier: MODEL1310110057#
is described by: ECO:0000269

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_28dfde35_7977_4945_a1d2_0b0526dcb2ec
initial concentration: NaN
name: _AI694761_1_c
initial amount: NaN
is encoded by: hsa:AI694761
type: Species
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252

metaR 4PYRDX
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT Reaction correct??? (active transport)
name: 4-Pyridoxal secretion
reactant: MODEL1310110057#
product: MODEL1310110057#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_dba8752d_cbe0_4ec8_b8fc_a9ca3a8dd3b8
boundary condition: true
name: SLC16A10
is: SBO:0000252
has only substance units: false
is encoded by: hsa:117247
type: Species
constant: false
initial concentration: NaN
is: Q8TF71
initial amount: NaN

metaM nadph m
is: HMDB00221
is: SBO:0000247
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: CHEBI:57783
constant: false
type: Species
is: C00005
boundary condition: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR PMEVKx
modifier: MODEL1310110057#
reactant: MODEL1310110057#
name: phosphomevalonate kinase
is: SBO:0000176
kinetic law: MODEL1310110057#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.4.2
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.4.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ

metaM alpam m
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB06239
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
name: S-aminomethyldihydrolipoamide

metaR r2092
fast: false
reversible: true
product: MODEL1310110057#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110057#
is described by: ECO:0000000

metaR NDPK9n
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction
fast: false
is described by: ECO:0000269
modifier: MODEL1310110057#
is: SBO:0000176
reversible: true
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear

metaR ACHEe
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
type: Reaction
product: MODEL1310110057#
is: SBO:0000176
fast: false
modifier: MODEL1310110057#
name: Acetylcholinesterase
reactant: MODEL1310110057#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.1.1.7

metaM vacccrn c
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
is: HMDB06351
boundary condition: false
is: SBO:0000247
name: Vaccenyl carnitine

metaM octdececrn c
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C25H47NO4 CHARGE: 0
has only substance units: false
constant: false
is: HMDB06351
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110057#_24431723_1ea4_48ff_9537_48687329a08f
is: Q13613
boundary condition: true
initial concentration: NaN
name: MTMR1
constant: false
is encoded by: hsa:8776
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaR FUT16g
name: Galactoside 2-alpha-L-fucosyltransferase 1
product: MODEL1310110057#
reversible: false
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.69
reactant: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_metaR_ACGALFUCGALACGALFUCGALACGLCGAL14ACGLCGALGLUSIDEtg
product: MODEL1310110057#
name: blood group intracellular transport
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
reactant: MODEL1310110057#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110057#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_75651e88_0d17_4a5a_8991_7c78a7bea8b6
has only substance units: false
is encoded by: hsa:5144
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q08499
type: Species
constant: false
name: PDE4D
initial amount: NaN

metaR APAT2rm
type: Reaction
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
fast: false
reversible: true
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
reactant: MODEL1310110057#
is: SBO:0000176
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.6.1.19
is described by: ECO:0000212
modifier: MODEL1310110057#

metaR FAOXC10C10OHm
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->OHC10)m
type: Reaction

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

metaR FAS140COA
name: fatty-acyl-CoA synthase (n-C14:0CoA)
product: MODEL1310110057#
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000269
reversible: false
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD

metaR DHEASULT
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.8.2.14
is described by: ECO:0000269
product: MODEL1310110057#
modifier: MODEL1310110057#
name: Dehydroepiandrosterone sulfotransferase
fast: false
kinetic law: MODEL1310110057#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.4
notes: GENE_ASSOCIATION: (6783.1) or (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:1588921 NOTES:NJ
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_5b7ddde0_a4e5_400e_bd7f_8701bfa6335b
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4731
is: SBO:0000252
is: P56181
constant: false
boundary condition: true
type: Species
name: NDUFV3

metaR ACETONEt2m
is: SBO:0000185
name: acetone mitochondrial transport via proton symport
reversible: true
reactant: MODEL1310110057#
is described by: ECO:0000000
modifier: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110057#
type: Reaction
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_a5c494e4_af62_4c9a_87db_80bb34ffe5d1
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
constant: false
name: _AI971036_1_c
initial amount: NaN
is encoded by: hsa:AI971036

metaR r2091
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110057#
type: Reaction
fast: false
product: MODEL1310110057#
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110057#
is described by: ECO:0000000
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110057#_d212f53e_5d05_4266_b945_6ce5c0d311d8
is: Q02218
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:4967
initial amount: NaN
name: OGDH
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_ac5dcbf4_cf30_47ef_85b6_9e9c168bc164
name: _AA526438_1_m
boundary condition: true
initial amount: NaN
is encoded by: hsa:AA526438
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
has only substance units: false

metaM for c
is: C00058
name: Formate
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15740
type: Species
is: HMDB00142
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_121183bd_f31d_45fa_bb59_7e036b81a525
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is: Q96C36
name: PYCR2
is encoded by: hsa:29920

metaR r1434
reactant: MODEL1310110057#
reversible: false
is described by: ECO:0000000
name: Transport reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:

metaR DCMPDA
reactant: MODEL1310110057#
product: MODEL1310110057#
name: dCMP deaminase
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.12
modifier: MODEL1310110057#
is described by: ECO:0000254
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
reversible: true
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_ca728b41_6e90_41f0_97ba_f1c196c110a6
is: SBO:0000252
constant: false
boundary condition: true
name: CHST4
is: Q8NCG5
is encoded by: hsa:10164
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false

metaM dolp L c
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
name: dolichyl phosphate(2-)
boundary condition: false
is: CHEBI:57683
initial amount: NaN

metaR FAOXC184C163m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C18:4-->C16:3)m
type: Reaction

metaM 3tetd7ecoacrn c
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C21H39NO5 CHARGE: 0
initial amount: NaN
constant: false
is: HMDB02014
boundary condition: false
name: 3-hydroxy tetradecenoyl-7-carnitine
has only substance units: false

metaR PEROXx
notes: GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ
reactant: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
name: peroxisomal lumped long chain fatty acid oxidation
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110057#
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110057#

metaM 3hdcoa m
has only substance units: false
boundary condition: false
name: (S)-3-Hydroxydecanoyl-CoA
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966

http://identifiers.org/biomodels.db/MODEL1310110057#_fdd08f61_1722_4380_b84a_0c1917bc9863
has only substance units: false
initial concentration: NaN
is: SBO:0000297
name: B4GALT1:LALBA
initial amount: NaN
constant: false
is encoded by: hsa:3906
type: Species
boundary condition: true
has part: P00709

metaR r2090
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110057#
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110057#
reactant: MODEL1310110057#

metaM dag hs n
initial amount: NaN
name: diglyceride
constant: false
initial concentration: 1.0
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
type: Species
boundary condition: false
is: CHEBI:18035
has only substance units: false
is: SBO:0000247

metaM gluside hs c
is: SBO:0000247
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial amount: NaN
initial concentration: 1.0
name: D-glucosyl-N-acylsphingosine
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:18368

metaM peamn c
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: HMDB12275
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
constant: false
name: 2-phenylethanaminium
is: CHEBI:225237
initial concentration: 1.0

metaM 10fthf m
constant: false
name: 10-formyltetrahydrofolate(2-)
is: SBO:0000247
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:57454
initial amount: NaN
is: HMDB00972

metaR EX srtn LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Serotonin exchange
type: Reaction

metaR M1316Mg
product: MODEL1310110057#
is: SBO:0000176
fast: false
reactant: MODEL1310110057#
modifier: MODEL1310110057#
reversible: false
kinetic law: MODEL1310110057#
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.114

http://identifiers.org/biomodels.db/MODEL1310110057#_cada5950_4f06_4e2a_9420_c1301182fc4e
is: Q5TDP6
is: SBO:0000252
name: LGSN
is encoded by: hsa:51557
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_metaR_ACGALFUCGALACGALFUCGALACGLCGAL14ACGLCGALGLUSIDEte
product: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
name: blood group intracellular transport
is: SBO:0000185
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ

metaR r1435
reactant: MODEL1310110057#
is described by: ECO:0000000
reversible: false
product: MODEL1310110057#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
name: Transport reaction
kinetic law: MODEL1310110057#

metaR HEXDICOAACBPx
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexadecanedioyl coa
type: Reaction

metaR PPD2CSPp
product: MODEL1310110057#
name: PPD2CSPp
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
reversible: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
is: SBO:0000176

metaR RE2660N
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/4.2.1.96
name: RE2660
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_8bf5dcb3_f4b4_4378_9c64_27c7047b76e8
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: GBA
type: Species
is encoded by: hsa:2629
constant: false
boundary condition: true

metaR RE1807M
fast: false
reversible: true
reactant: MODEL1310110057#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15
name: RE1807
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
product: MODEL1310110057#
is described by: ECO:0000000
modifier: MODEL1310110057#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_ad7dfa24_58c7_4399_b041_f9d5f7964020
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1103
name: CHAT
boundary condition: true
constant: false
initial amount: NaN
is: Q6LEN6
type: Species
is: SBO:0000252

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaR ARACHt
name: fatty acid transport via diffusion
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110057#
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110057#

metaM ksi pre27 g
is: C00130
is: CHEBI:58053
type: Species
is: HMDB00175
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 27
initial amount: NaN
constant: false
notes: FORMULA: C205H328N14O171S8X CHARGE: -9

metaR CRVNCtr
reactant: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
kinetic law: MODEL1310110057#
is: SBO:0000185
reversible: true
name: fatty acid transport via diffusion
type: Reaction
is described by: ECO:0000000

metaR C101CPT1
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decenoylcarnitine
type: Reaction

metaR MI145PK
name: inositol-1,4,5-trisphosphate 3-kinase
kinetic law: MODEL1310110057#
fast: false
modifier: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110057#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.127
reactant: MODEL1310110057#

metaM HC00664 c
type: Species
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-2-6(10)5(9)4(8)3(15-6)1-14-16(11,12)13/h3-5,7-10H,1-2H2,(H2,11,12,13)/p-2/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C01097
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
name: D-tagatofuranose 6-phosphate(2-)
is: SBO:0000247
is: CHEBI:58695

http://identifiers.org/biomodels.db/MODEL1310110057#_ccbb3133_f681_4a0d_9249_bf1071cbb1f8
constant: false
boundary condition: true
has only substance units: false
name: ADCY4
is: SBO:0000252
type: Species
initial amount: NaN
is: Q8NFM4
initial concentration: NaN
is encoded by: hsa:196883

metaR r1433
reversible: false
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
reactant: MODEL1310110057#
type: Reaction
is: SBO:0000176
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9

http://identifiers.org/biomodels.db/MODEL1310110057#_3ddd92d6_c3d7_4410_b4a9_2efe48363d04
boundary condition: true
is: O43505
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:11041
constant: false
has only substance units: false
name: B3GNT1

http://identifiers.org/biomodels.db/MODEL1310110057#_d612d37e_3f7d_4189_b307_90cf71055afa
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10020
constant: false
type: Species
initial amount: NaN
is: B7Z428
has only substance units: false
is: SBO:0000252
name: GNE

metaM CE0713 m
initial amount: NaN
is: SBO:0000247
name: 3-oxolinoleoyl-CoA
has only substance units: false
constant: false
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
type: Species
is: HMDB02329
boundary condition: false
is: CHEBI:30623
initial concentration: 1.0

metaR r2389
is described by: ECO:0000000
kinetic law: MODEL1310110057#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000185
type: Reaction
fast: false
reversible: false

metaM nadph r
is: C00005
type: Species
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial concentration: 1.0
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
has only substance units: false
is: HMDB00221
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:57783

http://identifiers.org/biomodels.db/MODEL1310110057#_966734d3_732c_4fb9_b7e0_d51235cb3e32
is: SBO:0000252
type: Species
is encoded by: hsa:81031
name: SLC2A10
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: O95528

metaM ptth c
is: HMDB03426
is: CHEBI:16753
constant: false
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
name: pantetheine

metaR FAOXC165C164m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

metaR r0707
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.168
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777 NOTES:
name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate phosphohydrolase (alkaline optimum) Folate biosynthesis EC:3.1.3.1
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110057#
product: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
is described by: ECO:0000000

metaR INSTt2r
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
is: SBO:0000185
type: Reaction
modifier: MODEL1310110057#
product: MODEL1310110057#
name: inositol transport in via proton symport
reversible: true
kinetic law: MODEL1310110057#
fast: false
reactant: MODEL1310110057#

metaR FAOXC4C4DCc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: succ-->C4DCc
type: Reaction

metaM gal l
name: D-galactose
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
is: CHEBI:12936
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00143
has only substance units: false
boundary condition: false

metaR CYTK3n
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
reversible: true
is: SBO:0000176
name: cytidylate kinase (dCMP,CTP),nuclear
type: Reaction
product: MODEL1310110057#
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_91c5e688_7ad4_4362_9f65_4e6aa4e7b288
constant: false
name: GGCT
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:79017
has only substance units: false
is: B8ZZR8
initial amount: NaN

metaM occoa m
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:57386
is: C01944
boundary condition: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: HMDB01070
constant: false
type: Species
name: Octanoyl-CoA (n-C8:0CoA)
has only substance units: false

metaM ksi pre12 g
type: Species
has only substance units: false
is: SBO:0000247
is: C00130
is: CHEBI:58053
boundary condition: false
constant: false
is: HMDB00175
initial concentration: 1.0
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 12

metaR r0706
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.10
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
fast: false
is: SBO:0000176
modifier: MODEL1310110057#
reactant: MODEL1310110057#

metaM strdnc c
boundary condition: false
is: C16300
has only substance units: false
is: HMDB06547
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: SBO:0000247
name: stearidonic acid C18:4, n-3
is: http://identifiers.org/pubchem.compound/47205608
constant: false
type: Species

metaR GLNS
reversible: false
reactant: MODEL1310110057#
type: Reaction
name: glutamine synthetase
modifier: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000254
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/4.1.1.15
fast: false
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110057#

metaR r1431
reactant: MODEL1310110057#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
is described by: ECO:0000000
product: MODEL1310110057#
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110057#_7490b6e6_dfe4_4e89_99ec_b90f0808f801
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
is: Q709F0
is encoded by: hsa:84129
name: ACAD11

http://identifiers.org/biomodels.db/MODEL1310110057#_761a6da4_a0d0_4843_a7b0_f16f3ef59baa
is: P14410
is: SBO:0000252
constant: false
initial amount: NaN
name: SI
is encoded by: hsa:6476
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true

metaR NP1
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
name: nucleotide phosphatase
product: MODEL1310110057#
is described by: ECO:0000304
is: SBO:0000176

metaR FAOXC141C141OHm
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C14:1OH)m
type: Reaction

metaR H6ET3er
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
is described by: ECO:0000000
kinetic law: MODEL1310110057#
reversible: false
product: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.1
type: Reaction
is: SBO:0000176
modifier: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD

metaM udpglcur c
name: UDP-D-glucuronate
constant: false
is: HMDB00935
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
boundary condition: false
initial concentration: 1.0
is: CHEBI:58052
type: Species
is: C00167

http://identifiers.org/biomodels.db/MODEL1310110057#_0d6fa131_85cf_4324_a2d0_6b6dff575479
is: Q16836
constant: false
initial concentration: NaN
has only substance units: false
name: HADH
type: Species
boundary condition: true
is encoded by: hsa:3033
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_5b4d150f_2fc7_48f5_8ab2_d61bc72206f5
constant: false
name: PIP4K2A
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P48426
is encoded by: hsa:5305
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_9dc75ea5_e347_4ec5_b74b_c5ca0d9e930b
name: PIP5K1B
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8395
initial concentration: NaN
constant: false
is: O14986
type: Species
boundary condition: true
initial amount: NaN

metaR r1655
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
product: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_7a01f36c_c6b5_4862_a53f_3d26a6d90689
constant: false
initial amount: NaN
name: PLA2G1B
has only substance units: false
boundary condition: true
is: P04054
initial concentration: NaN
is encoded by: hsa:5319
is: SBO:0000252
type: Species

metaR MI145PP
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
reactant: MODEL1310110057#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.86
type: Reaction
product: MODEL1310110057#
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.1.3.36
fast: false
name: inositol-1,4,5-trisphosphate 5-phosphatase

metaR DGNSKm
reactant: MODEL1310110057#
name: deoxyguanosine kinase
fast: false
product: MODEL1310110057#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.113
modifier: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (1716.5) or (1716.1) or (1716.4) or (1716.2) or (1716.3) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:8692979 NOTES:
kinetic law: MODEL1310110057#
is described by: ECO:0000269
is: SBO:0000176

metaM o2 r
is: HMDB01377
initial concentration: 1.0
is: C00007
name: O2
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
has only substance units: false

metaR INSt
is described by: ECO:0000269
type: Reaction
reversible: true
kinetic law: MODEL1310110057#
fast: false
modifier: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000185
reactant: MODEL1310110057#
name: Inosine transport (diffusion)
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR

http://identifiers.org/biomodels.db/MODEL1310110057#_081c0ac1_710a_47bc_ae7a_a6cc968757c0
constant: false
name: B4GALT1
initial concentration: NaN
is: P15291
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:2683

http://identifiers.org/biomodels.db/MODEL1310110057#_7836c018_f4bb_4cfe_a439_b2c7a023935c
initial concentration: NaN
is: P49888
type: Species
boundary condition: true
initial amount: NaN
name: SULT1E1
is encoded by: hsa:6783
is: SBO:0000252
has only substance units: false
constant: false

metaR TTDCRNt
product: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
name: transport into the mitochondria (carnitine)
reversible: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110057#_8d95ca5c_0c7a_4b4b_a5d2_c6251ca1b9ae
constant: false
is: O00400
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:9197
type: Species
name: SLC33A1

http://identifiers.org/biomodels.db/MODEL1310110057#_453cb7f0_cd6b_48c1_aec5_e22b1c3614c5
is: Q9NVE7
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
name: PANK4
is encoded by: hsa:55229
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_e9fadf50_135c_4767_b5c2_3e7671379af6
name: SLC20A2
boundary condition: true
is: B2RBR4
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:6575
type: Species

metaR DMNONCOACRNCPT1
kinetic law: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
name: DMNONCOACRNCPT1
reactant: MODEL1310110057#
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_485dd24a_999d_46fd_96cf_519b5be86a9c
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaR 2HCO3 NAt
kinetic law: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
fast: false
is described by: ECO:0000269
is: SBO:0000185
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
reversible: true
modifier: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM

metaR ABTArm
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110057#
is: SBO:0000176
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
modifier: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.19.4 Confidence Level: 4 AUTHORS: PMID:10407778,PMID:7721088 NOTES:kh 1/6/03
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.6.1.19
reversible: true
fast: false

metaM strdnc e
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: http://identifiers.org/pubchem.compound/47205608
is: HMDB06547
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: C16300
constant: false
has only substance units: false
name: stearidonic acid C18:4, n-3

metaM atp x
is: CHEBI:57299
is: HMDB00538
is: C00002
boundary condition: false
name: ATP(4-)
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_421be226_4e1a_48c2_8adc_a2fb745af40a
type: Species
is: A8MYF6
has only substance units: false
is encoded by: hsa:6307
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: MSMO1

metaR CYTK2n
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
name: cytidylate kinase (dCMP),nuclear
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110057#
reversible: true
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
fast: false

metaR r0166
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
product: MODEL1310110057#

metaR r1654
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110057#
type: Reaction
fast: false
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000185
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_07d9481f_19d2_491d_afcd_b2a12b513338
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
constant: false
name: _AI769281_1_e
is: SBO:0000252
is encoded by: hsa:AI769281
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_6d53e033_a319_47a9_b8be_8350f024173c
is encoded by: hsa:8503
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000297
constant: false
has part: A7E2E0
initial concentration: NaN
type: Species
is encoded by: hsa:5293
has part: Q92569
name: PIK3CD:PIK3R3

metaR FAOXC165C164x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:5-->C16:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_6ae82f3c_4a13_4f20_a06c_f908d720d69e
constant: false
is: SBO:0000252
boundary condition: true
is: O95168
has only substance units: false
type: Species
initial concentration: NaN
name: NDUFB4
initial amount: NaN
is encoded by: hsa:4710

metaR AKGMALtm
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
name: alpha-ketoglutarate/malate transporter
fast: false
modifier: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110057#
reversible: true
reactant: MODEL1310110057#
product: MODEL1310110057#
type: Reaction

metaR GALACGLCGALGBSIDEte
fast: false
name: galacglcgalgbside hs transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
is described by: ECO:0000000
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000185
type: Reaction
reversible: true

metaR EX 3hdececrn
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecenoyl carnitine
type: Reaction

metaM ach c
is: CHEBI:15355
initial concentration: 1.0
constant: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: HMDB00895
name: acetylcholine
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR CRNCARtp
reactant: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110057#
is: SBO:0000185
name: carnitine-acetylcarnitine carrier, peroxisomal
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110057#

metaM vacccrn m
is: HMDB06351
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
name: Vaccenyl carnitine
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false

metaR OCD11COACPT1
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR BTNPLm
reactant: MODEL1310110057#
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
fast: false
is: SBO:0000176
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/6.3.4.10
is described by: ECO:0000000
kinetic law: MODEL1310110057#
reversible: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_9b0b5b77_009b_4631_a3dc_67d4394a7f79
is encoded by: hsa:1798
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q9H3H5
type: Species
name: DPAGT1

metaR r1653
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110057#
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110057#
is: SBO:0000185
product: MODEL1310110057#
type: Reaction
modifier: MODEL1310110057#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR C161CPT22
name: C161 transport into the mitochondria
modifier: MODEL1310110057#
reactant: MODEL1310110057#
reversible: false
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
kinetic law: MODEL1310110057#
is: SBO:0000176
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_95fd3325_114d_454a_b340_7da19019f31e
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: ALDH1A3
is encoded by: hsa:220
has only substance units: false
is: P47895
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_282d49e6_b9f6_4f00_b0cf_d3d7ab243ab1
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
name: PKM2
is: P14618
is encoded by: hsa:5315
boundary condition: true
is: SBO:0000252

metaR GALSIDEtg
type: Reaction
product: MODEL1310110057#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
reactant: MODEL1310110057#
name: galactocerebroside intracellular transport
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_6a62457a_21e1_449d_84aa_da57802b6a36
boundary condition: true
is encoded by: hsa:6487
name: ST3GAL3
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_0fdbf8d6_48f7_40b0_a0d3_539b8dc40af6
is: P15328
type: Species
constant: false
is: SBO:0000252
boundary condition: true
name: FOLR1
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2348

metaR EX 5mthf LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 5-Methyltetrahydrofolate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_fceb328d_76f7_4e77_a024_79bc8edbbf33
type: Species
name: _AA532636_1_m
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:AA532636
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR RE3626M
name: RE3626
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
product: MODEL1310110057#
is described by: ECO:0000000
reactant: MODEL1310110057#
reversible: false
modifier: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
fast: false

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_f8f4c189_6400_4dde_a8e0_e9ae07492ef2
boundary condition: true
is: A8K7J7
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: HK1
is encoded by: hsa:3098

metaM ach e
name: acetylcholine
initial concentration: 1.0
constant: false
is: HMDB00895
is: CHEBI:15355
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
has only substance units: false
is: SBO:0000247

metaM lac L e
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:16651
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00190
name: (S)-lactate
initial amount: NaN

metaR r1652
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110057#
is described by: ECO:0000000
modifier: MODEL1310110057#
fast: false
type: Reaction
product: MODEL1310110057#
reactant: MODEL1310110057#
reversible: true
is: SBO:0000185

metaM hLkynr c
initial concentration: 1.0
initial amount: NaN
is: HMDB11631
is: CHEBI:17380
name: 3-hydroxy-L-kynurenine
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_94abeda6_70ea_44cc_9f20_375fbb50a735
name: ALPL
is: B7Z4Y6
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:249

metaR FAOXC15C13m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C15-->C13)m
type: Reaction

metaR NADPHtru
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
is: SBO:0000185
name: NADPH transporter, endoplasmic reticulum
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: false
product: MODEL1310110057#

metaM o2 m
type: Species
initial concentration: 1.0
is: C00007
name: O2
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:15379
has only substance units: false
boundary condition: false
is: HMDB01377
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007

metaM gal c
has only substance units: false
initial concentration: 1.0
name: D-Galactose
is: C00124
is: HMDB00143
is: CHEBI:0
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0
constant: false

metaR FAOXC225C226m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

metaM oh1 c
has only substance units: false
is: C01328
initial concentration: 1.0
is: HMDB01039
type: Species
boundary condition: false
notes: FORMULA: HO CHARGE: -1
name: hydroxide ion
initial amount: NaN
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_75750d25_2fca_402c_bbeb_c20eb2ddf963
initial amount: NaN
is: Q4FEB3
initial concentration: NaN
is encoded by: hsa:1215
is: SBO:0000252
type: Species
name: CMA1
boundary condition: true
constant: false
has only substance units: false

metaR r1651
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110057#
modifier: MODEL1310110057#
reactant: MODEL1310110057#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_b5b466ba_4820_40de_a056_fb9fa2d842cf
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
name: NT5C1B
initial amount: NaN
is: Q96P26
is encoded by: hsa:93034

metaM galgbside hs g
initial concentration: 1.0
type: Species
is: CHEBI:18259
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
name: galactosylgloboside
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110057#_6f94e8f0_d303_4412_b6ed_f4cba3a999f2
initial amount: NaN
is: P40394
boundary condition: true
name: ADH7
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:131
type: Species

metaM ditp c
is: HMDB03537
boundary condition: false
is: CHEBI:61382
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
name: dITP(4-)
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345

metaR MALSO3tm
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reversible: true
name: Malate:sulfite antiport, mitochondrial
is described by: ECO:0000269
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
modifier: MODEL1310110057#

metaR r1590
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000000

metaM 34dhmald m
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB06242
name: 3,4-Dihydroxymandelaldehyde
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
constant: false
is: C05577
boundary condition: false
is: http://identifiers.org/pubchem.compound/7903
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_19f1c6b0_859b_4833_a297_c226374f873c
boundary condition: true
is encoded by: hsa:1629
initial concentration: NaN
type: Species
initial amount: NaN
is: P11182
is: SBO:0000252
name: DBT
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_fe3ccfdf_5950_49ac_bcff_32c1b93bd3ea
is encoded by: hsa:570
initial concentration: NaN
has only substance units: false
name: BAAT
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is: Q14032
constant: false

metaR FAOXC184C164m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)m
type: Reaction

metaR INSTt4 2
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: true
is described by: ECO:0000006
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
fast: false
is: SBO:0000185
type: Reaction
name: inositol transport via sodium symport
product: MODEL1310110057#
modifier: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_e3b9f2aa_994a_41d9_a650_571a3cde5256
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:482
is: SBO:0000252
name: ATP1B2
initial concentration: NaN
constant: false
is: P14415
has only substance units: false

metaM xoltriol m
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:16496
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
is: HMDB01457
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
initial amount: NaN

metaR P5CRxm
fast: false
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.5.1.2
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:PRO1x is irreversible in the other direction
name: pyrroline-5-carboxylate reductase (m)
kinetic law: MODEL1310110057#
is: SBO:0000176
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is described by: ECO:0000304
type: Reaction
reversible: false

metaM dec47dicoa m
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
name: 4,7-decadienoylcoa
is: http://identifiers.org/pubchem.compound/16019966
type: Species
boundary condition: false
is: SBO:0000247

metaR PAFt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110057#
fast: false
name: 1-alkyl 2-acteylglycerol 3-phosphocholine transport
reversible: true
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000000

metaR NACHEXA19ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
type: Reaction
modifier: MODEL1310110057#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: false
reactant: MODEL1310110057#
name: beta-N-acetylhexosaminidase A, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110057#_9bcc202d_0e51_4ed3_968f_90050ca360cb
name: RRM1
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6240
has only substance units: false
constant: false
initial amount: NaN
is: P23921

metaM damp c
name: dAMP(2-)
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
type: Species
is: HMDB00905
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:58245
initial concentration: 1.0
constant: false

metaR PTDCACRNCPT1
reversible: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
kinetic law: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
modifier: MODEL1310110057#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110057#
reactant: MODEL1310110057#
name: carnitine fatty-acyl transferase

metaR RE2799C
reactant: MODEL1310110057#
fast: false
is: SBO:0000176
name: RE2799
product: MODEL1310110057#
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:

metaR r1650
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_1084fddf_6f93_4636_8abc_9aa398a71b64
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
name: _AW299740_1_m
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:AW299740

metaM sebcoa x
boundary condition: false
has only substance units: false
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
initial concentration: 1.0
type: Species
initial amount: NaN
name: sebacoylcoa
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
constant: false

metaM c6dc x
has only substance units: false
is: HMDB04047
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: SBO:0000247
is: C14143
name: adipoyl carnitine
notes: FORMULA: C13H22NO6 CHARGE: -1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_30a221da_23db_4fad_87fe_30af889deea4
is encoded by: hsa:51301
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: GCNT4
is: Q9P109

http://identifiers.org/biomodels.db/MODEL1310110057#_ee65b5dc_553f_446a_88b4_69aac6bfa78e
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10606
initial amount: NaN
is: SBO:0000252
is: P22234
constant: false
name: PAICS
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_14f2f28f_9c0c_4f2a_816f_3be7cf56cbbb
initial amount: NaN
is: O43181
is encoded by: hsa:4724
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
name: NDUFS4
is: SBO:0000252

metaM 3hdeccoa m
constant: false
has only substance units: false
type: Species
is: HMDB02288
name: 3-hydroxyhexadecenoylcoa
initial concentration: 1.0
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR TDCHOLAte
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
name: bile acid intracellular transport
type: Reaction
product: MODEL1310110057#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110057#_b88d0568_be09_4312_8b3e_a41b407ed364
is: O00142
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: TK2
has only substance units: false
is encoded by: hsa:7084

metaM gal e
is: HMDB00143
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:0
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0
is: C00124
is: SBO:0000247
has only substance units: false
name: D-Galactose
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_67feb683_439d_46f8_912b_fe9cc401ba17
initial concentration: NaN
initial amount: NaN
name: PCYT2
constant: false
type: Species
boundary condition: true
has only substance units: false
is: F5H8B1
is: SBO:0000252
is encoded by: hsa:5833

http://identifiers.org/biomodels.db/MODEL1310110057#_41dc7f5a_a954_4899_8b3d_1a1d2555f1f1
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:353
initial concentration: NaN
constant: false
is: P07741
initial amount: NaN
name: APRT
has only substance units: false

metaR CRNtx
name: carnitine transport peroxisome to mitochondria
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
product: MODEL1310110057#
fast: false
reversible: true
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000000

metaR PTDCACRNCPT2
product: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000176
name: pentadecanoate transport into the mitochondria
modifier: MODEL1310110057#
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ

metaR FUT15g
product: MODEL1310110057#
reversible: false
fast: false
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
name: Galactoside 2-alpha-L-fucosyltransferase 1
is version of: http://identifiers.org/ec-code/2.4.1.69
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110057#
type: Reaction

metaM CE5120 m
type: Species
boundary condition: false
name: trans-2-cis-8-tetradecadienoyl-CoA
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
has only substance units: false
is: CHEBI:57923

http://identifiers.org/biomodels.db/MODEL1310110057#_ba50dce4_80ed_478d_836b_72390a6141e8
has only substance units: false
name: AK2
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:204
is: SBO:0000252
type: Species

metaM accoa c
is: HMDB01206
is: C00024
is: CHEBI:57288
type: Species
has only substance units: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: Acetyl-CoA
initial concentration: 1.0
constant: false

metaR 3SALAASPm
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
name: cysteinesulfinate-aspartate mitochondrial shuttle
kinetic law: MODEL1310110057#
product: MODEL1310110057#
fast: false
is described by: ECO:0000304
modifier: MODEL1310110057#
reversible: true
reactant: MODEL1310110057#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_b5970998_76a9_46c3_a80c_4aeac785659f
is encoded by: hsa:6539
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: P48065
name: SLC6A12

metaR ARACHDtr
is: SBO:0000185
product: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
name: intracellular transport
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaR RE2426C
name: RE2426
is: SBO:0000176
product: MODEL1310110057#
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:
reversible: true
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_9ec10585_8d2a_4299_be52_10ebf6122414
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:518
initial concentration: NaN
initial amount: NaN
type: Species
name: ATP5G3

http://identifiers.org/biomodels.db/MODEL1310110057#_91c60c40_2ace_4d23_9f10_cfb63c21f18b
constant: false
is encoded by: hsa:8398
name: PLA2G6
is: O60733
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR CDIPTr
reversible: true
fast: false
modifier: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
is: SBO:0000176
name: phosphatidylinositol synthase (Homo sapiens)
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
is version of: http://identifiers.org/ec-code/2.7.8.11
is described by: ECO:0000000

metaR AG13T17g
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110057#
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110057#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110057#_cb7b7fbc_18eb_4bbb_a626_e9b246968632
has only substance units: false
boundary condition: true
is: O76074
initial amount: NaN
name: PDE5A
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:8654
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_a6512e91_e1fc_411e_9404_45e3ce67da46
initial amount: NaN
is encoded by: hsa:2678
initial concentration: NaN
has only substance units: false
is: P19440
is: SBO:0000252
type: Species
boundary condition: true
constant: false
name: GGT1

metaM ksi deg5 l
initial concentration: 1.0
is: CHEBI:12936
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
is: HMDB00143
constant: false
has only substance units: false
name: keratan sulfate I, degradation product 5

metaR NAt3 1
reactant: MODEL1310110057#
product: MODEL1310110057#
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: true
type: Reaction
is: SBO:0000185
name: sodium proton antiporter (H:NA is 1:1)
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
is described by: ECO:0000269
fast: false

metaR GALSIDEtl
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
reversible: true
product: MODEL1310110057#
is described by: ECO:0000000
name: galactocerebroside intracellular transport
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110057#_e4734c28_9049_4237_8da0_80b6aee7bcb2
is encoded by: hsa:5152
has only substance units: false
constant: false
name: PDE9A
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR FORMCOAtx
type: Reaction
reactant: MODEL1310110057#
reversible: true
product: MODEL1310110057#
is described by: ECO:0000000
name: formyl coa transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism see Verhoeven 11591435 and clayton 11356171 - added for peroxisomal oxidation of fatty acids NJ
is: SBO:0000185
fast: false
kinetic law: MODEL1310110057#

metaR EX CE2915 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-casomorphin exchange
type: Reaction

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_f041fb4f_d692_4da2_a575_260d450092c7
boundary condition: true
name: FLAD1
is: SBO:0000252
is encoded by: hsa:80308
constant: false
initial concentration: NaN
type: Species
is: Q8NFF5
has only substance units: false
initial amount: NaN

metaR r1594
reversible: true
product: MODEL1310110057#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110057#

metaR PA HStn
reactant: MODEL1310110057#
name: phosphatidate transport, nuclear
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110057#
fast: false
type: Reaction
product: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000185

metaR ARGDCm
notes: GENE_ASSOCIATION: (113451.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.19 Confidence Level: 4 AUTHORS: PMID:14752610 NOTES:SAB m
product: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.19
kinetic law: MODEL1310110057#
reversible: false
type: Reaction
reactant: MODEL1310110057#
modifier: MODEL1310110057#
name: arginine decarboxylase (m)
is: SBO:0000176
is described by: ECO:0000269

metaM ficytC m
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
has only substance units: false
is: CHEBI:15991
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
name: Ferricytochrome c
boundary condition: false
type: Species

metaR FAOXC5C3x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C3)m
type: Reaction

metaR ILETA
is: SBO:0000176
kinetic law: MODEL1310110057#
name: isoleucine transaminase
reversible: true
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
is version of: http://identifiers.org/ec-code/2.6.1.42
fast: false
reactant: MODEL1310110057#
type: Reaction
modifier: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000269

metaM cs c deg3 l
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 3
is: SBO:0000247
notes: FORMULA: C31H48NO32S2 CHARGE: -3
is: CHEBI:15748
is: HMDB00127
type: Species
has only substance units: false

metaM gdp c
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:58189
is: C00035
has only substance units: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
constant: false
name: GDP
initial concentration: 1.0
is: HMDB01201
is: SBO:0000247

metaR FAOXC180
name: Beta oxidation of long chain fatty acid
product: MODEL1310110057#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110057#
reversible: false
fast: false
is: SBO:0000176
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#

metaR r1593
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110057#
product: MODEL1310110057#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_170d42e3_7afb_4289_84ce_a02df44de0df
initial amount: NaN
is: P34896
is encoded by: hsa:6470
constant: false
boundary condition: true
name: SHMT1
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_36eb989e_b5a7_454d_b2e7_df1992b491d3
is encoded by: hsa:9060
name: PAPSS2
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
is: O95340
is: SBO:0000252
initial concentration: NaN

metaR DNDPt26m
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
is described by: ECO:0000269
reversible: false
is: SBO:0000185
name: dCDP transport via dUDP antiport
type: Reaction
product: MODEL1310110057#
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_feb68137_9446_49fb_9985_f1cee96aff2b
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2530
initial concentration: NaN
is: B4DFS7
constant: false
type: Species
name: FUT8

metaR EX vacc LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: vaccenic acid exchange
type: Reaction

metaR NACASPAH
reversible: false
is: SBO:0000176
reactant: MODEL1310110057#
is described by: ECO:0000269
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (443.1) or (91703.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.15 Confidence Level: 4 AUTHORS: PMID:8252036 NOTES:SAB
kinetic law: MODEL1310110057#
type: Reaction
fast: false
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.5.1.15
name: N-Acetyl-L-aspartate amidohydrolase

http://identifiers.org/biomodels.db/MODEL1310110057#_e058a669_5ad8_419b_af3c_921f31d9bfc6
has only substance units: false
initial concentration: NaN
has part: Q06055
is: SBO:0000297
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:517
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2

metaR FMNAT
name: FMN adenylyltransferase
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
reactant: MODEL1310110057#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.2
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reversible: false
is described by: ECO:0000134
fast: false
modifier: MODEL1310110057#
type: Reaction

metaR PAIL HStn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110057#
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
name: phosphatidylinositol nuclear transport (diffusion)

metaM zym int2 r
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: CHEBI:52386
boundary condition: false
is: SBO:0000247
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
name: zymosterol intermediate 2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_c069fd8d_1282_42e6_a436_190449130e22
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:1718
has only substance units: false
is: Q15392
constant: false
name: DHCR24

metaR ETF
is described by: ECO:0000000
reactant: MODEL1310110057#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
is: SBO:0000176
reversible: false
product: MODEL1310110057#
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
name: electron transfer flavoprotein

http://identifiers.org/biomodels.db/MODEL1310110057#_bf989f85_d2be_49cb_9c58_10b2e3f6d16e
type: Species
constant: false
name: NMNAT3
is: Q96T66
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:349565
has only substance units: false

metaR CYSO
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
name: cysteine oxidase
kinetic law: MODEL1310110057#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.20
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110057#
fast: false
product: MODEL1310110057#
modifier: MODEL1310110057#

metaR r1592
reactant: MODEL1310110057#
product: MODEL1310110057#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true

metaM oh1 e
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
name: hydroxide ion
is: SBO:0000247
notes: FORMULA: HO CHARGE: -1
type: Species
is: C01328
initial concentration: 1.0
is: HMDB01039

metaM occoa x
boundary condition: false
is: C01944
is: CHEBI:57386
name: Octanoyl-CoA (n-C8:0CoA)
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
has only substance units: false
is: HMDB01070

http://identifiers.org/biomodels.db/MODEL1310110057#_0f8c6cdf_2679_43a3_a7c2_aba25daf4240
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110057#_eef71a87_434a_4e32_a9c0_20fa9e21f326
type: Species
initial concentration: NaN
is: SBO:0000252
name: ACAT2
constant: false
is encoded by: hsa:39
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q9BWD1

http://identifiers.org/biomodels.db/MODEL1310110057#_bf44e89f_d914_4e68_b5c0_1c1d479f6855
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
is: E7EPT3
boundary condition: true
initial concentration: NaN
is encoded by: hsa:501
has only substance units: false
name: ALDH7A1

metaR r1591
reversible: true
product: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM gdp e
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
name: GDP(3-)
type: Species
is: HMDB01201
constant: false
is: CHEBI:58189
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM mhista c
name: N(tele)-methylhistaminium
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00898
initial concentration: 1.0
constant: false
notes: FORMULA: C6H12N3 CHARGE: 1 INCHI: InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3/p+1 EHMN_ABBREVIATION: C05127
is: CHEBI:58600
boundary condition: false
type: Species

metaR PMTCOAtx
is: SBO:0000185
reactant: MODEL1310110057#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
kinetic law: MODEL1310110057#
name: fatty acid intracellular transport

metaR GLUPRT
reactant: MODEL1310110057#
name: glutamine phosphoribosyldiphosphate amidotransferase
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
is version of: http://identifiers.org/ec-code/2.4.2.14
is described by: ECO:0000269
fast: false
reversible: false
product: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110057#_96bf4284_557d_49d1_be3e_40664fedfcc5
initial amount: NaN
name: GALNT5
type: Species
constant: false
has only substance units: false
boundary condition: true
is: A5PKZ1
is: SBO:0000252
is encoded by: hsa:11227
initial concentration: NaN

metaR DUDPtn
is described by: ECO:0000000
is: SBO:0000185
name: dUDP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110057#
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110057#
product: MODEL1310110057#

metaR r2380
product: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110057#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction

metaR RE2626C
product: MODEL1310110057#
reversible: true
is: SBO:0000176
name: RE2626
type: Reaction
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:

metaM 2dr5p c
is: CHEBI:57651
initial concentration: 1.0
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
constant: false
is: HMDB01031
has only substance units: false
is: SBO:0000247
boundary condition: false
name: 2-deoxy-D-ribose 5-phosphate(2-)
type: Species
initial amount: NaN

metaR FAOXC163C164x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)x
type: Reaction

metaR PROSTGE1t
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
name: prostaglandin transport via bicarbonate countertransport
modifier: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#
fast: false

metaR BILIRUBtr
name: lipid, flip-flop intracellular transport
reversible: true
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110057#
type: Reaction

metaR sink octdececoa LPAREN c RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: OCTDECECOASINK
type: Reaction

metaM xoltriol c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
is: HMDB01457
type: Species
is: CHEBI:16496
has only substance units: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454

metaR MANt1r
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
modifier: MODEL1310110057#
name: mannose transport (uniport)
kinetic law: MODEL1310110057#
fast: false
product: MODEL1310110057#
reactant: MODEL1310110057#
reversible: true
is described by: ECO:0000269
type: Reaction
is: SBO:0000185

metaR GLYCt
reversible: true
is: SBO:0000185
name: glycerol transport via channel
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
product: MODEL1310110057#
type: Reaction
is described by: ECO:0000000
fast: false

metaR r1598
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#

metaM coa c
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: HMDB01423
name: Coenzyme A
is: CHEBI:3312
is: C00010
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110057#_bc4c181a_02e8_42cf_86a2_6302c18ad4ae
initial concentration: NaN
type: Species
is: Q86YN1
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: DOLPP1
has only substance units: false
is encoded by: hsa:57171

http://identifiers.org/biomodels.db/MODEL1310110057#_00f74848_58bc_4108_a63a_5fe564926c12
is encoded by: hsa:R06874
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
name: _R06874_1_r

metaR DDCRNe
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydodecanoyl carnitine into extra cellular space
type: Reaction

metaR r1659
reactant: MODEL1310110057#
modifier: MODEL1310110057#
product: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110057#_f57346c1_1869_4a63_90c9_d0ae3716c96a
name: PDE9A
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:5152
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true

MODEL1310110057
reaction: metaR sink 5hpet LPAREN c RPAREN
species: metaM 3snpyr m
reaction: metaR r0784
species: metaM utp n
reaction: metaR ASNALANaEx
reaction: metaR RE0453M
species: metaM gthrd m
species: metaM tetdece1crn c
reaction: metaR FAOXTC122m
reaction: metaR COUCOAFm
reaction: metaR r0747
species: metaM ksi pre26 g
reaction: metaR r1164
species: metaM HC02203 c
reaction: metaR SUCCCROT
reaction: metaR CYTK10n
reaction: metaR EX Rtotal2 LPAREN e RPAREN
reaction: metaR OBDHc
species: metaM h2o c
species: metaM h m
species: metaM CE4790 m
reaction: metaR BTNt2
species: metaM gbside hs g
species: metaM cs c deg3 l
species: metaM taur c
species: metaM idp c
species: metaM ala D c
reaction: metaR SUCRe
reaction: metaR r1552
reaction: metaR NDP7er
species: metaM dcmp n
species: metaM thymd m
reaction: metaR FAOXC18C18OHm
reaction: metaR r0354
species: metaM ksi pre36 g
reaction: metaR CERT2rt
reaction: metaR EX HC01610 LPAREN e RPAREN
species: metaM thbpt4acam n
species: metaM ivcrn e
species: metaM for r
species: metaM agm m
reaction: metaR NACHEXA19ly
reaction: metaR ATPS4m
species: metaM dhbpt c
species: metaM ptdcacoa c
reaction: metaR r0750
reaction: metaR PEAMNO
species: metaM gtp e
species: metaM 3ttetddcoacrn c
reaction: metaR GCC2bim
reaction: metaR MDHm
reaction: metaR FAOXC2031836m
reaction: metaR r1659
reaction: metaR PALFATPtc
species: metaM malcoa c
reaction: metaR r0819
reaction: metaR r0559
reaction: metaR N2M2NMASNtly
reaction: metaR RE0689E
reaction: metaR FAOXC2242046m
species: metaM ksi deg3 l
species: metaM acmanap c
reaction: metaR r1106
species: metaM prostgh2 c
reaction: metaR FAOXC184x
species: metaM dad 2 e
reaction: metaR INSTt2r
reaction: metaR FAEL183
species: metaM tststerones e
reaction: metaR EX maltpt LPAREN e RPAREN
reaction: metaR FAOXC184C163m
species: metaM 3hibutcoa m
reaction: metaR r0835
reaction: metaR ASNGLNNaEx
reaction: metaR IPDDIx
reaction: metaR DOLPMT L
reaction: metaR NACASPAH
species: metaM 5mta c
species: metaM 4izp c
reaction: metaR EX crm hs LPAREN e RPAREN

http://identifiers.org/biomodels.db/MODEL1310110057#_a83d79ba_e128_4614_880b_a6703454c0ec
is: SBO:0000252
is: P19801
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:26
name: ABP1

metaM o2 e
name: O2
has only substance units: false
is: HMDB01377
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
is: CHEBI:15379
is: C00007

http://identifiers.org/biomodels.db/MODEL1310110057#_22e27ced_ba88_45de_a8bd_b9c7f10aa28e
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaM leuktrD4 c
is: CHEBI:28666
has only substance units: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
constant: false
initial concentration: 1.0
name: Leukotriene D4
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB03080

metaM lac L c
boundary condition: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
name: (S)-lactate
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:16651
is: HMDB00190
initial concentration: 1.0
type: Species

metaR r1597
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110057#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110057#
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110057#

metaR AKR1D2
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
reactant: MODEL1310110057#
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110057#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.3.1.3

http://identifiers.org/biomodels.db/MODEL1310110057#_969b51ad_ebb6_48de_9c66_ebee5b21fc11
initial concentration: NaN
is encoded by: hsa:1609
has only substance units: false
is: P52824
name: DGKQ
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true

metaM tyr L e
boundary condition: false
is: SBO:0000247
is: CHEBI:17895
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
name: L-tyrosine
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: HMDB00158
has only substance units: false

metaM gdp g
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB01201
name: GDP(3-)
constant: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: CHEBI:58189
initial amount: NaN

metaM C05279 m
boundary condition: false
initial concentration: 1.0
name: trans,cis-Lauro-2,6-dienoyl-CoA
type: Species
is: SBO:0000247
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
is: CHEBI:28387
has only substance units: false
constant: false
initial amount: NaN
is: HMDB11123

http://identifiers.org/biomodels.db/MODEL1310110057#_62b58876_74b0_4e9a_98fd_4fef87d331d2
initial concentration: NaN
initial amount: NaN
is: O75746
type: Species
constant: false
boundary condition: true
name: SLC25A12
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8604

metaR VITD3t2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
type: Reaction
fast: false
name: Vitamin D3 uptake
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: false
is described by: ECO:0000000
product: MODEL1310110057#
is: SBO:0000185

metaR FAOXC163GC142m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaR r1658
reactant: MODEL1310110057#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110057#
is: SBO:0000185
kinetic law: MODEL1310110057#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r1596
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110057#
reversible: true
is described by: ECO:0000000

metaM pro L m
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
name: L-proline
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: CHEBI:17203
is: HMDB00162

http://identifiers.org/biomodels.db/MODEL1310110057#_2cfd5676_a003_4f2c_8e99_f83a9cc1362d
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is: P31639
initial amount: NaN
boundary condition: true
has only substance units: false
name: SLC5A2
is encoded by: hsa:6524

http://identifiers.org/biomodels.db/MODEL1310110057#_ac692b00_d9e3_4c63_bf93_c96852d2fbf8
initial amount: NaN
boundary condition: true
is: Q9ULC5
type: Species
initial concentration: NaN
is encoded by: hsa:51703
constant: false
has only substance units: false
is: SBO:0000252
name: ACSL5

metaR FAOXC225C226x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_c003d10b_3700_47db_8b80_ec7ca2b4a56f
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:2821
has only substance units: false
type: Species
is: SBO:0000252
is: P06744
name: GPI
initial amount: NaN

metaM dhf m
name: dihydrofolate(2-)
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57451
is: HMDB01056

metaM coa e
is: HMDB01423
constant: false
type: Species
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287
is: SBO:0000247
is: C00010
name: Coenzyme A
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR SERASNNaEx
name: L-serine/L-asparagine Na-dependent exchange (Ser-L in)
type: Reaction
fast: false
is described by: ECO:0000269
product: MODEL1310110057#
reversible: false
is: SBO:0000185
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110057#

metaR FATP2t
is: SBO:0000185
reversible: true
fast: false
modifier: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
name: fatty acid electroneutral transport
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000269

metaM o2 c
is: C00007
is: HMDB01377
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
constant: false
is: CHEBI:15379
has only substance units: false
name: O2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_190ac3e1_7894_4b05_bcbe_a244d35b43a6
is: SBO:0000252
is encoded by: hsa:4023
initial concentration: NaN
boundary condition: true
type: Species
is: P06858
constant: false
has only substance units: false
name: LPL
initial amount: NaN

metaR r1657
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110057#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110057#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
reactant: MODEL1310110057#
fast: false
modifier: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_a6aa1c4f_0d5b_4b27_bb3d_6cbea6cd0618
is: O60476
boundary condition: true
is encoded by: hsa:10905
name: MAN1A2
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species

metaR FAOXC161802m
is described by: ECO:0000269
name: Beta oxidation fatty acid
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110057#
fast: false
type: Reaction
reactant: MODEL1310110057#

metaR NaKt
modifier: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
is described by: ECO:0000269
is: SBO:0000185
fast: false
name: Na+/K+ exchanging ATPase
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)
is version of: http://identifiers.org/ec-code/3.6.3.9
product: MODEL1310110057#
reversible: false

metaR r1595
fast: false
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaM 3hdeccoa c
initial amount: NaN
initial concentration: 1.0
name: 3-hydroxyhexadecenoylcoa
has only substance units: false
is: SBO:0000247
constant: false
type: Species
is: HMDB02014
boundary condition: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4

metaM udpglcur r
is: SBO:0000247
is: CHEBI:58052
name: UDP-D-glucuronate
is: C00167
initial concentration: 1.0
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
boundary condition: false
type: Species
constant: false
is: HMDB00935
has only substance units: false
initial amount: NaN

metaM tyr L c
is: HMDB00158
name: L-tyrosine
has only substance units: false
initial concentration: 1.0
is: CHEBI:17895
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085

metaR r0160
reactant: MODEL1310110057#
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
product: MODEL1310110057#
reversible: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.3.2
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_5e760d8a_2d5b_40aa_9580_ac3dfb5c8e24
has only substance units: false
type: Species
is: P48736
initial amount: NaN
initial concentration: NaN
name: PIK3CG
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5294

metaM Rtotalcoa c
has only substance units: false
is: HMDB01448
initial amount: NaN
constant: false
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
type: Species
name: R total Coenzyme A
is: SBO:0000247
is: CHEBI:16189
boundary condition: false
initial concentration: 1.0

metaM CE1944 c
is: CHEBI:36781
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
name: 1-pyrrolinium
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944

metaR r1656
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110057#
reversible: true
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaM 5forthf c
constant: false
boundary condition: false
is: CHEBI:57456
name: 5-Formiminotetrahydrofolate
is: HMDB01534
initial amount: NaN
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
initial concentration: 1.0
is: C00664
has only substance units: false
type: Species
is: SBO:0000247

metaR BILGLCURtr
reactant: MODEL1310110057#
is described by: ECO:0000000
product: MODEL1310110057#
kinetic law: MODEL1310110057#
name: glucuronidated compound transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
is: SBO:0000185
fast: false
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_c2001f82_86dc_4711_bd32_ba62d42e39cb
boundary condition: true
initial amount: NaN
is encoded by: hsa:5048
type: Species
has only substance units: false
is: P43034
constant: false
name: PAFAH1B1
is: SBO:0000252
initial concentration: NaN

metaR r0714
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
reversible: false
reactant: MODEL1310110057#
product: MODEL1310110057#
kinetic law: MODEL1310110057#

metaM pcrn m
type: Species
boundary condition: false
has only substance units: false
constant: false
is: HMDB00824
is: http://identifiers.org/pubchem.compound/107738
name: propionyl-carnitine
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3

metaR VLCSp
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is: SBO:0000176
name: Very-long-chain-fatty-acid-CoA ligase
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: false
product: MODEL1310110057#
reactant: MODEL1310110057#

metaR EHGLATm
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
modifier: MODEL1310110057#
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
is described by: ECO:0000212

metaR G14Tg
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: false
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110057#

metaR LNLNCGCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
product: MODEL1310110057#
modifier: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000269
name: carnitine transferase
kinetic law: MODEL1310110057#
reversible: false
fast: false
reactant: MODEL1310110057#

metaM HC01522 c
is: CHEBI:28508
is: SBO:0000247
initial amount: NaN
type: Species
name: Gentisate aldehyde
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
has only substance units: false

metaR RE2649C
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110057#
is: SBO:0000176
kinetic law: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
name: RE2649

metaR r1599
product: MODEL1310110057#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110057#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110057#
is described by: ECO:0000000

metaR r2087
type: Reaction
product: MODEL1310110057#
fast: false
reversible: true
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110057#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110057#

metaM leuktrD4 e
has only substance units: false
is: HMDB03080
boundary condition: false
is: CHEBI:28666
initial amount: NaN
constant: false
type: Species
name: Leukotriene D4
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: SBO:0000247
initial concentration: 1.0

metaR r2376
product: MODEL1310110057#
kinetic law: MODEL1310110057#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
reactant: MODEL1310110057#
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110057#_23624bf8_bc25_4501_87da_9b99f4396024
boundary condition: true
name: LDHC
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3948
initial amount: NaN
initial concentration: NaN
is: P07864
constant: false

metaR LNLNCGCPT1
type: Reaction
product: MODEL1310110057#
is: SBO:0000176
name: carnitine O-palmitoyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110057#
reversible: false
fast: false
reactant: MODEL1310110057#
modifier: MODEL1310110057#

metaM 2hexdtricoa m
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: 2,7,10-hexadecatrienoylcoa
is: HMDB02288
boundary condition: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C37H56N7O17P3S CHARGE: -4

metaM adrncoa m
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205480
constant: false
name: adrenyl coenzyme A
boundary condition: false
is: SBO:0000247
is: C16170

http://identifiers.org/biomodels.db/MODEL1310110057#_518e44a9_8658_4cb0_a971_665fb7e071a4
has only substance units: false
is: SBO:0000252
is encoded by: hsa:53630
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q9HAY6
type: Species
name: BCMO1

metaM 4mop m
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
is: SBO:0000247
has only substance units: false
is: HMDB00695
type: Species
initial amount: NaN
is: CHEBI:17865
name: 4-methyl-2-oxopentanoate

metaR GALASE12ly
product: MODEL1310110057#
modifier: MODEL1310110057#
is described by: ECO:0000000
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110057#
type: Reaction

metaR ACCOAC
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaR HDECEACBP
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecenoylcoa from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_fefc66bf_cb6f_438d_82c0_95d0df3506f8
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:3030
is: E9KL44
initial concentration: NaN
boundary condition: true
name: HADHA
constant: false
is: SBO:0000252

metaR 41R2A1H12BOOX
modifier: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.4
is described by: ECO:0000269
type: Reaction
reversible: false
name: 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_4194c7c7_c447_4d13_b21c_50fa5693eb46
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is: Q96CD2
is encoded by: hsa:60490
has only substance units: false
initial concentration: NaN
type: Species
name: PPCDC

http://identifiers.org/biomodels.db/MODEL1310110057#_04a1d810_a5e3_4c99_a64f_bae52b881fa5
initial concentration: NaN
has part: P56134
is encoded by: hsa:9551
is: SBO:0000297
has only substance units: false
is encoded by: hsa:522
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
type: Species
initial amount: NaN
boundary condition: true
constant: false

metaM HC02203 c
is: CHEBI:27820
initial concentration: 1.0
boundary condition: false
name: prostaglandin-a2
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
type: Species
is: SBO:0000247

metaR r2375
kinetic law: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
product: MODEL1310110057#

metaR r2086
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
product: MODEL1310110057#
reactant: MODEL1310110057#
modifier: MODEL1310110057#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
kinetic law: MODEL1310110057#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_32d07141_9513_4c0f_839a_5cb62eeb2669
is encoded by: hsa:211
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: P13196
boundary condition: true
initial concentration: NaN
name: ALAS1
constant: false
type: Species

metaR r0716
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
kinetic law: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
product: MODEL1310110057#
is described by: ECO:0000000

metaR GLYt7 211 r
is described by: ECO:0000269
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
name: glycine reversible transport via sodium and chloride symport (2:1:1)

metaR VLCSr
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
reactant: MODEL1310110057#
is: SBO:0000176
kinetic law: MODEL1310110057#
is described by: ECO:0000269
reversible: false
fast: false
name: Very-long-chain-fatty-acid-CoA ligase
modifier: MODEL1310110057#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110057#

metaM ditp n
name: dITP(4-)
constant: false
type: Species
is: HMDB03537
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
is: CHEBI:61382
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR 2AMADPTm
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
is described by: ECO:0000269
type: Reaction
product: MODEL1310110057#
fast: false
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
kinetic law: MODEL1310110057#
is: SBO:0000185
reversible: true
modifier: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_18dc229c_7091_4759_95a9_745a196a65f3
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:6549
name: SLC9A2
is: Q9UBY0
type: Species
has only substance units: false
is: SBO:0000252

metaR GULN3D
fast: false
reactant: MODEL1310110057#
is: SBO:0000176
name: L-gulonate 3-dehydrogenase
kinetic law: MODEL1310110057#
reversible: true
type: Reaction
product: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD

metaM accoa r
initial concentration: 1.0
name: acetyl-CoA(4-)
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:57288
is: SBO:0000247
is: HMDB01206
has only substance units: false
type: Species

metaR r2089
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110057#
product: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110057#

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR 2MB2COAc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 2-methylcrotonoyl-CoA into cytosol
type: Reaction

metaM 3ttetddcoacrn e
boundary condition: false
is: HMDB02014
constant: false
notes: FORMULA: C21H37NO5 CHARGE: 0
initial amount: NaN
has only substance units: false
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR r2374
is described by: ECO:0000000
kinetic law: MODEL1310110057#
product: MODEL1310110057#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110057#
reversible: true
fast: false
is: SBO:0000185

metaM pentcoa m
boundary condition: false
name: pentanoylcoa
has only substance units: false
is: C00888
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
is: HMDB13037
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_8b5cde68_56dc_45f6_9ae8_34d30df7c348
initial concentration: NaN
is: O60909
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN
name: B4GALT2
is encoded by: hsa:8704

metaM acnam n
constant: false
initial concentration: 1.0
is: CHEBI:35418
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial amount: NaN
name: N-acetylneuraminate
type: Species
boundary condition: false
is: HMDB00230
has only substance units: false
is: SBO:0000247

metaM dec47dicoa x
constant: false
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: 4,7-decadienoylcoa
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110057#_b4f7d339_9fc2_464b_96d7_f1b52aaab071
is encoded by: hsa:6521
initial concentration: NaN
has only substance units: false
type: Species
is: P02730
initial amount: NaN
constant: false
is: SBO:0000252
name: SLC4A1
boundary condition: true

metaR r0715
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
is described by: ECO:0000000
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
type: Reaction
reactant: MODEL1310110057#
modifier: MODEL1310110057#
reversible: false
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/6.3.2.5
kinetic law: MODEL1310110057#
fast: false

metaR CREATt4 2 r
reactant: MODEL1310110057#
reversible: true
modifier: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110057#
name: Creatine transport (sodium symport) (2:1)
product: MODEL1310110057#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_43c9b77f_1c63_47b6_b8cd_fbfb7571bdd6
constant: false
initial amount: NaN
has only substance units: false
is: G5E960
is: SBO:0000252
type: Species
is encoded by: hsa:5331
name: PLCB3
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_efe91a1f_382b_469e_b697_99c01b897638
name: SLC7A8:SLC3A2
boundary condition: true
is: SBO:0000297
type: Species
has part: Q9UHI5
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:23428

metaR r2088
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_36be0a82_7b23_4285_9007_a02b72b8ba94
type: Species
initial concentration: NaN
constant: false
is: O75715
boundary condition: true
is encoded by: hsa:2880
name: GPX5
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_9aae3956_4d2c_4e62_946c_436bec285e4d
initial concentration: NaN
name: MTHFS
is encoded by: hsa:10588
boundary condition: true
is: P49914
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN

metaR r2373
reactant: MODEL1310110057#
is described by: ECO:0000000
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110057#
reversible: true

metaR NACHEXA3ly
reversible: false
kinetic law: MODEL1310110057#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110057#
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
fast: false
product: MODEL1310110057#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52

metaM Ssq23epx r
is: HMDB01188
constant: false
type: Species
name: (S)-2,3-epoxysqualene
is: CHEBI:15441
is: SBO:0000247
boundary condition: false
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR 4NPHte
reactant: MODEL1310110057#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: true
name: xenobiotic transport
is: SBO:0000185

metaR ATP2ter
type: Reaction
is: SBO:0000185
product: MODEL1310110057#
name: AMP/ATP transporter, endoplasmic reticulum
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
is described by: ECO:0000000

metaR r2083
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110057#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_8280839c_1d4f_412d_a793_2fa63291e665
is: B7Z6S1
constant: false
is: SBO:0000252
type: Species
has only substance units: false
name: GBA
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2629

http://identifiers.org/biomodels.db/MODEL1310110057#_c944536f_18b6_4c28_adc2_0275f9c67b6d
constant: false
name: ENPP1
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P22413
type: Species
initial amount: NaN
is encoded by: hsa:5167
is: SBO:0000252

metaR SRTNt6 2 r
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000269
modifier: MODEL1310110057#
fast: false
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_1c360c3b_85a1_4dd5_9fba_91c2aad35c13
type: Species
is encoded by: hsa:1956
is: P00533
constant: false
initial amount: NaN
name: EGFR
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_7664cb3b_6b3d_44fc_a0d1_eddb5725ccff
is: SBO:0000252
name: NDUFS6
initial concentration: NaN
is: Q6IBC4
initial amount: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:4726
has only substance units: false

metaM 3ttetddcoacrn c
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
is: HMDB02014
has only substance units: false
notes: FORMULA: C21H37NO5 CHARGE: 0
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_b629b6f7_ce09_4283_b9d0_8d0269795ecb
initial concentration: NaN
has only substance units: false
is encoded by: hsa:7296
name: TXNRD1
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false

metaR r2372
is described by: ECO:0000000
product: MODEL1310110057#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110057#
fast: false
type: Reaction
kinetic law: MODEL1310110057#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM g1m8masn r
is: C05875
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C76H127N2O60X CHARGE: 0
has only substance units: false
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_d7bf003a_ac3a_4beb_a29b_2d8423bb64eb
has only substance units: false
name: DGKI
is encoded by: hsa:9162
initial concentration: NaN
is: O75912
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true

metaR C10DCCACT
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacoyl carnitine into cytosol
type: Reaction

metaM sphgn c
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
initial concentration: 1.0
boundary condition: false
is: HMDB00269
constant: false
initial amount: NaN
is: CHEBI:57817
is: SBO:0000247
type: Species
name: sphinganine(1+)
has only substance units: false

metaR HEXDIACTD
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

metaM xyl D c
initial amount: NaN
constant: false
name: aldehydo-D-xylose
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
is: SBO:0000247
boundary condition: false
is: CHEBI:15936
type: Species

metaR ACONTm
is described by: ECO:0000134
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/4.2.1.3
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
reactant: MODEL1310110057#
product: MODEL1310110057#
reversible: true
type: Reaction
fast: false
name: Aconitate hydratase
is: SBO:0000176

metaM tdchola c
name: taurochenodeoxycholate
is: CHEBI:9407
boundary condition: false
has only substance units: false
type: Species
is: HMDB00951
initial amount: NaN
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR r1116
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000185
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
fast: false
is described by: ECO:0000000
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
type: Reaction
reversible: true

metaR r2082
product: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110057#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110057#

metaM adp m
name: ADP
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:456216
is: C00008
has only substance units: false
is: http://identifiers.org/pubchem.compound/3310
constant: false
is: HMDB01341
type: Species

metaR r2371
kinetic law: MODEL1310110057#
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110057#
fast: false

metaM ppcoa c
is: CHEBI:57392
constant: false
initial amount: NaN
is: HMDB01275
has only substance units: false
type: Species
name: Propanoyl-CoA
is: C00100
is: SBO:0000247
boundary condition: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110057#_b737308c_0b33_45be_bd64_a907c00d5b73
type: Species
name: AOC3
has only substance units: false
is: Q16853
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:8639
initial concentration: NaN
is: SBO:0000252

metaM ksi deg4 l
type: Species
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
has only substance units: false
is: HMDB00868
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: keratan sulfate I, degradation product 4
is: CHEBI:57737
constant: false

metaM hx2coa m
is: http://identifiers.org/pubchem.compound/11966188
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB06870
name: trans-Hex-2-enoyl-CoA
is: SBO:0000247
constant: false
type: Species
is: C05998
initial concentration: 1.0
notes: FORMULA: C27H40N7O17P3S CHARGE: -4

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaM adp n
is: HMDB01341
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:456216
name: ADP(3-)
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247

metaR OCTDECCACT
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaM retinal 11 cis c
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: HMDB02152
type: Species
constant: false
has only substance units: false
is: CHEBI:16066
is: SBO:0000247
name: 11-cis-retinal
initial concentration: 1.0

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_8b12e387_32a9_4114_a7c2_2f2c02d4cdb5
is encoded by: hsa:6487
initial amount: NaN
name: ST3GAL3
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false

metaR r2085
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110057#
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR r1117
name: Facilitated diffusion
kinetic law: MODEL1310110057#
is described by: ECO:0000000
product: MODEL1310110057#
is: SBO:0000185
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
reactant: MODEL1310110057#

metaR CYTK9
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110057#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,dCTP)
reversible: true

metaM mag hs c
is: HMDB12130
name: monoacylglycerol 2
initial amount: NaN
is: CHEBI:16987
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_bab2ccbc_5818_4729_bb53_ed165262057a
initial amount: NaN
is encoded by: hsa:AA664770
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
name: _AA664770_1_m
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_5abea368_1338_453d_888e_3d2f20ef44ca
boundary condition: true
initial amount: NaN
is encoded by: hsa:271
initial concentration: NaN
constant: false
type: Species
is: Q01433
is: SBO:0000252
has only substance units: false
name: AMPD2

http://identifiers.org/biomodels.db/MODEL1310110057#_bd9c8a70_297d_4a8d_aa52_fd91b9deb999
is: SBO:0000252
is encoded by: hsa:276
is: Q6NSB3
type: Species
has only substance units: false
name: AMY1A
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false

metaM tdchola e
initial concentration: 1.0
name: taurochenodeoxycholate
is: SBO:0000247
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
constant: false
initial amount: NaN
type: Species
is: HMDB00951
boundary condition: false
has only substance units: false
is: CHEBI:9407

metaM 5aizc c
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
is: C04751
has only substance units: false
is: CHEBI:58564
is: HMDB06273
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
type: Species
initial amount: NaN

metaM 10fthf7glu e
is: HMDB00972
initial amount: NaN
boundary condition: false
notes: FORMULA: C50H57N13O25 CHARGE: -8
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:57454
name: 10-formyltetrahydrofolate-[Glu](7)
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110057#_4c94cf4a_f87c_4dad_9667_e9333d954ac0
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
name: QPRT
is encoded by: hsa:23475
has only substance units: false
is: Q15274
is: SBO:0000252
constant: false

metaR GALASE5ly
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110057#
fast: false
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR r2084
product: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110057#
is: SBO:0000185
reversible: true
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction

metaM HC02203 e
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
type: Species
name: prostaglandin-a2
has only substance units: false
is: CHEBI:27820
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
is: SBO:0000247

metaR EX c3dc
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for malonyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_099185e0_fb34_4463_811f_b9ad3ac93c47
has only substance units: false
constant: false
boundary condition: true
name: GALE
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2582
is: Q38G75
type: Species

metaM bildglcur c
is: HMDB03325
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:58471
initial concentration: 1.0
boundary condition: false
name: bis(beta-glucosyluronate)bilirubin
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: SBO:0000247
constant: false

metaM retinol cis 11 e
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: CHEBI:16302
name: 11-cis-retinol
is: HMDB06216
is: SBO:0000247
type: Species

metaM 4nphsf c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
has only substance units: false
type: Species
initial concentration: 1.0
name: 4-Nitrophenyl sulfate
is: CHEBI:35422
constant: false
initial amount: NaN
is: HMDB06492

metaR S6T3g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.2.17
reversible: false
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.21
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
reactant: MODEL1310110057#
product: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction

metaR SGPL12r
modifier: MODEL1310110057#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/4.1.2.27
type: Reaction
fast: false
product: MODEL1310110057#
name: Sphingosine-1-phosphate lyase

metaM man e
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:16024
initial amount: NaN
is: HMDB00169
is: C00159
boundary condition: false
name: D-Mannose
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_f108841b_1eda_4df3_853b_d320f9cceea5
has only substance units: false
initial amount: NaN
name: HSD11B1
is: P28845
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:3290
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_d293ba56_d283_4635_9557_24769564073c
is: P48201
is encoded by: hsa:518
initial amount: NaN
name: ATP5G3
boundary condition: true
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial concentration: NaN

metaM etfrd m
notes: FORMULA: RH2 CHARGE: 0
is: CHEBI:17263
boundary condition: false
initial amount: NaN
type: Species
name: Electron transfer flavoprotein reduced
has only substance units: false
is: HMDB00145
constant: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_30475df3_bb21_4d9d_965d_4994fceb019d
is: SBO:0000252
has only substance units: false
name: SGPP2
type: Species
initial amount: NaN
initial concentration: NaN
is: Q8IWX5
boundary condition: true
constant: false
is encoded by: hsa:130367

metaR C81CRNe
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octenoyl carnitine into the extra cellular space
type: Reaction

metaR PI45P3K
reversible: false
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110057#

metaR r1010
fast: false
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
kinetic law: MODEL1310110057#
name: Postulated transport reaction

metaM 4hexdtetcoa x
is: HMDB02288
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false
name: 4,7,10,13-hexadecatetraenoylcoa
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR r1446
type: Reaction
reactant: MODEL1310110057#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
fast: false
product: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110057#
name: EC:1.3.3.6

http://identifiers.org/biomodels.db/MODEL1310110057#_24b443c8_78a1_4ce3_9bf9_0de5ea371c2f
is encoded by: hsa:9926
is: SBO:0000252
boundary condition: true
constant: false
is: Q92604
name: LPGAT1
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR FAOXC16180m
modifier: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
name: Beta oxidation fatty acid

metaR FUT17g
is version of: http://identifiers.org/ec-code/2.4.1.69
product: MODEL1310110057#
is: SBO:0000176
modifier: MODEL1310110057#
is described by: ECO:0000269
fast: false
type: Reaction
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
reversible: false
name: Galactoside 2-alpha-L-fucosyltransferase 1

metaR r0086
type: Reaction
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
is described by: ECO:0000000
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.3
reversible: false
product: MODEL1310110057#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_da198726_fe41_408c_b863_6dbc41ad8ce7
constant: false
is: Q16775
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: HAGH
is encoded by: hsa:3029

http://identifiers.org/biomodels.db/MODEL1310110057#_c99720d5_b471_45f6_9e2b_ab1aab35c395
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: MTMR2
initial concentration: NaN
is: A6NN98
type: Species
is encoded by: hsa:8898

metaM bildglcur e
is: HMDB03325
is: CHEBI:58471
has only substance units: false
type: Species
constant: false
boundary condition: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: bis(beta-glucosyluronate)bilirubin

metaM 4mop e
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:17865
constant: false
has only substance units: false
type: Species
is: HMDB00695
initial amount: NaN
name: 4-methyl-2-oxopentanoate
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1

http://identifiers.org/biomodels.db/MODEL1310110057#_2776fdd4_be6f_4e1d_9f4e_f2c49994bdce
is: SBO:0000252
name: _AI640625_1_c
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:AI640625
type: Species

metaM o2 x
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007
constant: false
has only substance units: false
is: CHEBI:15379
name: O2
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01377

http://identifiers.org/biomodels.db/MODEL1310110057#_2da6cfa4_3958_4bd7_b893_d901033b2229
initial amount: NaN
type: Species
is encoded by: hsa:55512
initial concentration: NaN
has only substance units: false
name: SMPD3
is: Q9NY59
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_5c66fc15_e7a2_42c6_a189_53bd82455093
type: Species
name: COX8C
constant: false
initial amount: NaN
is encoded by: hsa:341947
boundary condition: true
is: Q7Z4L0
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM accoa g
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
name: acetyl-CoA(4-)
is: CHEBI:57288
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species
initial amount: NaN
is: HMDB01206

metaR PROD2m
type: Reaction
kinetic law: MODEL1310110057#
name: Proline dehydrogenase (m)
modifier: MODEL1310110057#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
is described by: ECO:0000254
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.99.8
product: MODEL1310110057#
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_0583585b_3288_4cfe_b9c8_1eabb6b408ea
is: P49327
is encoded by: hsa:2194
constant: false
name: FASN
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaR r1011
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
product: MODEL1310110057#
reversible: false
type: Reaction
is described by: ECO:0000000
name: Transport reaction
kinetic law: MODEL1310110057#
fast: false
is: SBO:0000185

metaR SERDGLYexR
is: SBO:0000185
product: MODEL1310110057#
name: D-Serine/Glycine reversible exchange
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000304
kinetic law: MODEL1310110057#

metaR RE2999M
modifier: MODEL1310110057#
type: Reaction
reversible: true
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/5.3.3.8
name: RE2999
reactant: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM HC01410 m
name: (2E)-Hexenoyl-CoA
is: CHEBI:28706
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110057#_feb476b2_cc08_4acc_9f39_44839311897d
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:AI090874
initial amount: NaN
name: _AI090874_1_c

metaR r1670
is: SBO:0000185
kinetic law: MODEL1310110057#
type: Reaction
name: Y+LAT2 Utilized transport
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110057#

metaM retinol cis 11 c
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
name: 11-cis-retinol
is: CHEBI:16302
is: HMDB06216
initial concentration: 1.0
is: SBO:0000247

metaR UMPK3n
reactant: MODEL1310110057#
name: UMP kinase (UTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110057#
fast: false
modifier: MODEL1310110057#
product: MODEL1310110057#
reversible: true
type: Reaction
is described by: ECO:0000269
is: SBO:0000176

metaM man c
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
name: D-Mannose
is: CHEBI:16024
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
is: C00159
constant: false
initial amount: NaN
is: HMDB00169
type: Species

metaR r2081
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110057#
fast: false
modifier: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
reversible: true

metaM cs c l
constant: false
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
is: SBO:0000247
name: chondroitin sulfate C (GalNAc6S-GlcA), free chain
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:36005
is: HMDB02183

metaR r1012
kinetic law: MODEL1310110057#
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
product: MODEL1310110057#
reversible: false
name: Postulated transport reaction

metaM sebcoa c
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
initial concentration: 1.0
is: HMDB00651
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: sebacoylcoa
boundary condition: false

metaR MI134P4P
kinetic law: MODEL1310110057#
fast: false
product: MODEL1310110057#
reversible: false
is: SBO:0000176
name: inositol-1,3,4-trisphosphate 4-phosphatase
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110057#

metaM 10fthf5glu e
is: HMDB00972
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:57454
name: 10-formyltetrahydrofolate-[Glu](5)
is: SBO:0000247
notes: FORMULA: C40H45N11O19 CHARGE: -6
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110057#_06dfd8ad_44c2_4c52_89cf_9a654a0eb84c
has only substance units: false
name: ATP5H
is: O75947
is encoded by: hsa:10476
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_da0acbe3_55fd_4eec_b707_959597aa8999
name: NDUFB6
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:4712
is: SBO:0000252
is: O95139
initial concentration: NaN
constant: false
initial amount: NaN

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaM adp r
type: Species
name: ADP(3-)
is: HMDB01341
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:456216
is: SBO:0000247
constant: false

metaM ser L m
initial concentration: 1.0
constant: false
name: L-serine
boundary condition: false
initial amount: NaN
is: CHEBI:17115
type: Species
is: HMDB00187
has only substance units: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_a96c12ce_8857_43fb_a518_663f4602b2f9
name: ATP5J
is: Q6IB54
is encoded by: hsa:522
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR r1671
reactant: MODEL1310110057#
reversible: true
kinetic law: MODEL1310110057#
type: Reaction
fast: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110057#
is: SBO:0000185

metaM 4mop c
initial amount: NaN
is: HMDB00695
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
is: CHEBI:17865
has only substance units: false
name: 4-methyl-2-oxopentanoate
constant: false
type: Species

metaR Q10H2e
is: SBO:0000185
reactant: MODEL1310110057#
reversible: true
fast: false
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
kinetic law: MODEL1310110057#
product: MODEL1310110057#
name: transport of ubiquinol into lymph

http://identifiers.org/biomodels.db/MODEL1310110057#_ccfea622_2ea9_496c_bcb6_4ae1ce9a6aca
is: Q6PXP3
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:155184
has only substance units: false
name: SLC2A7

metaM adrncoa c
is: C16170
is: http://identifiers.org/pubchem.compound/47205480
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
name: adrenyl coenzyme A
initial amount: NaN
constant: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1

metaR r2080
kinetic law: MODEL1310110057#
is: SBO:0000185
modifier: MODEL1310110057#
reactant: MODEL1310110057#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110057#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM ach n
name: acetylcholine
initial amount: NaN
is: CHEBI:15355
has only substance units: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: HMDB00895
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
boundary condition: false

metaR FBP26
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
modifier: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.105
notes: GENE_ASSOCIATION: (2203.1) or (5210.1) or (5207.1) or (5209.1) or (5208.1) or (8789.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 3.1.3.46 Confidence Level: 0 AUTHORS: NOTES:IF
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.11
product: MODEL1310110057#
name: Fructose-2,6-bisphosphate 2-phosphatase
fast: false

metaR r1013
name: Transport reaction
reversible: false
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110057#
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110057#_a28d5f2a_67b8_499d_93ce_042b7c6377fc
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8790
type: Species
name: FPGT
constant: false
is: O14772
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR r0149
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.39
fast: false
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110057#
product: MODEL1310110057#

metaR XOL7AH2tm
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110057#
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110057#
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_d2e96c45_03b1_4efa_bbfe_eed949964091
constant: false
is encoded by: hsa:AI915649
name: _AI915649_1_c
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252

metaR VALLAT1tc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Valine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_3160b88e_7c9e_4185_b843_57138732e71a
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: SLC22A3
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:6581
type: Species
is: Q5SYN6

metaM dump n
type: Species
constant: false
is: HMDB01409
name: dUMP(2-)
has only substance units: false
is: CHEBI:246422
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: SBO:0000247
initial concentration: 1.0

metaM icit c
is: HMDB00193
constant: false
has only substance units: false
initial amount: NaN
is: C00311
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
type: Species
is: CHEBI:16087
initial concentration: 1.0
is: SBO:0000247
name: Isocitrate
boundary condition: false

metaR r0083
is version of: http://identifiers.org/ec-code/1.1.1.42
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
product: MODEL1310110057#
reversible: true
reactant: MODEL1310110057#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110057#_db802589_7678_424d_b672_aa7079f6120c
initial concentration: NaN
type: Species
boundary condition: true
name: SLC26A6
is encoded by: hsa:65010
is: SBO:0000252
has only substance units: false
is: Q548A7
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_a9263231_e364_4353_91da_bc9e574077e6
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: LDHD
initial concentration: NaN
boundary condition: true
is encoded by: hsa:197257

metaR r0718
modifier: MODEL1310110057#
is described by: ECO:0000000
reactant: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.1.1.181
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reversible: false
product: MODEL1310110057#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaR ALAR
is described by: ECO:0000212
modifier: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000176
reactant: MODEL1310110057#
type: Reaction
fast: false
name: alanine racemase
kinetic law: MODEL1310110057#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_23fba6cf_ba3a_4fa9_953e_ef1a5891688d
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
name: AK5
is: SBO:0000252
is encoded by: hsa:26289
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_023d5f78_5bc0_42e5_84eb_7087bada4ebd
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: P22303
constant: false
name: ACHE
is encoded by: hsa:43

metaM Lcystin e
has only substance units: false
is: HMDB00192
name: L-cystine
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
initial concentration: 1.0
constant: false
is: CHEBI:16283
type: Species

metaR CYTD
is: SBO:0000176
modifier: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
type: Reaction
reversible: false
kinetic law: MODEL1310110057#
is described by: ECO:0000254
name: cytidine deaminase
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.5

metaM tre e
boundary condition: false
is: CHEBI:16551
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
constant: false
is: HMDB00975
initial amount: NaN
is: SBO:0000247
is: C01083
initial concentration: 1.0
type: Species
has only substance units: false
name: Trehalose

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_metaR_GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEtg
reactant: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is described by: ECO:0000000
name: blood group intracellular transport
kinetic law: MODEL1310110057#
is: SBO:0000185
fast: false
reversible: true

metaR r1014
name: Postulated transport reaction
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
reactant: MODEL1310110057#
fast: false
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000185

metaM dump m
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
type: Species
constant: false
is: HMDB01409
has only substance units: false
is: CHEBI:246422
initial concentration: 1.0
initial amount: NaN
name: dUMP(2-)
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110057#_bcb8c1d1_a761_49fb_ba83_9624546ab445
type: Species
is: Q6IBC4
name: NDUFS6
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4726
has only substance units: false

metaR r2379
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction
is: SBO:0000185
product: MODEL1310110057#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaM man6p c
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
is: SBO:0000247
name: D-Mannose 6-phosphate
type: Species
is: HMDB01078
is: CHEBI:17369
has only substance units: false

metaR FUM
is: SBO:0000176
name: fumarase
reactant: MODEL1310110057#
product: MODEL1310110057#
modifier: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.2
type: Reaction

metaM docohexcoa x
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
is: SBO:0000247
constant: false
name: 2,4,7,10,13,16-docosahexenoylcoa
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110057#_611dfd59_d193_45e0_ac3e_7fdebcf8aa9d
is: P16930
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:2184
name: FAH
initial amount: NaN

metaR r1443
reactant: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
product: MODEL1310110057#
reversible: false
name: EC:1.3.3.6

http://identifiers.org/biomodels.db/MODEL1310110057#_f0f0b256_7837_445a_bbad_dc065039204f
has only substance units: false
is: Q8IXK2
constant: false
initial concentration: NaN
is encoded by: hsa:79695
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: GALNT12

http://identifiers.org/biomodels.db/MODEL1310110057#_6f31f034_2505_47c5_a185_a7d075d9f815
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:8402
name: SLC25A11
is: SBO:0000252
has only substance units: false
is: F5GY65
boundary condition: true
initial concentration: NaN

metaR r0717
is: SBO:0000176
product: MODEL1310110057#
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_50e7e4d2_b80e_4f3a_a007_8eff42db923d
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:8813
initial concentration: NaN
has only substance units: false
is: O60762
type: Species
initial amount: NaN
name: DPM1

http://identifiers.org/biomodels.db/MODEL1310110057#_d086530e_efa5_42fd_92ed_bbaf9c8c6c95
is: SBO:0000252
constant: false
type: Species
is: Q7GXZ1
has only substance units: false
is encoded by: hsa:4541
initial amount: NaN
initial concentration: NaN
name: ND6
boundary condition: true

metaM pdx5p c
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C8H10NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00459 EHMN_ABBREVIATION: C00627
boundary condition: false
constant: false
name: Pyridoxine 5'-phosphate
initial concentration: 1.0
is: HMDB01319
is: C00627
initial amount: NaN
is: CHEBI:58589

metaR RE0690E
is version of: http://identifiers.org/ec-code/1.4.3.22
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000000
modifier: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
name: RE0690
type: Reaction
reversible: false
is: SBO:0000176

metaM acnam l
is: HMDB00230
initial amount: NaN
is: SBO:0000247
is: CHEBI:35418
type: Species
has only substance units: false
name: N-acetylneuraminate
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
boundary condition: false
constant: false
initial concentration: 1.0

metaM xol7ah2 m
is: CHEBI:28047
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
type: Species
has only substance units: false
initial amount: NaN
is: HMDB06893
name: 5beta-cholestane-3alpha,7alpha-diol

metaR DSAT
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110057#
name: dihydrosphingosine N-acyltransferase
is: SBO:0000176
reactant: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ

http://identifiers.org/biomodels.db/MODEL1310110057#_26057170_c069_47df_972e_fadf801e479b
has only substance units: false
type: Species
is: O75414
boundary condition: true
is encoded by: hsa:10201
is: SBO:0000252
initial concentration: NaN
name: NME6
constant: false
initial amount: NaN

metaR CYTK4n
reactant: MODEL1310110057#
reversible: true
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
modifier: MODEL1310110057#
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
kinetic law: MODEL1310110057#
name: cytidylate kinase (dCMP,GTP),nuclear

metaR r2378
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
is described by: ECO:0000000

metaM lnlccrn m
type: Species
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
is: SBO:0000247
initial amount: NaN
name: Linoleyl carnitine
constant: false
initial concentration: 1.0
is: HMDB06469
boundary condition: false
has only substance units: false

metaR HBZOPT10m
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.5.1.39
notes: GENE_ASSOCIATION: (27235.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:15153069,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.5.1.- IT
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
name: Hydroxybenzoate Decaprenyltransferase
fast: false
type: Reaction
product: MODEL1310110057#
is: SBO:0000176

metaR THRSERNaEx
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
product: MODEL1310110057#
name: L-serine/L-threonine Na-dependent exchange (Thr-L in)
type: Reaction
modifier: MODEL1310110057#
reversible: false
is: SBO:0000185

metaR NAGA2ly
kinetic law: MODEL1310110057#
reversible: false
name: N-acetylgalactosaminidase, alpha-
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
reactant: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.49
fast: false
modifier: MODEL1310110057#
product: MODEL1310110057#

metaR r0085
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110057#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176
modifier: MODEL1310110057#
fast: false
reversible: false
product: MODEL1310110057#
kinetic law: MODEL1310110057#

metaR GLYPHEPEPT1tc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycylphenylalanine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR RE1525M
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110057#
name: RE1525
type: Reaction
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110057#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_metaR_GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEte
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110057#
name: blood group intracellular transport
kinetic law: MODEL1310110057#
product: MODEL1310110057#

metaR GASNASE2ly
name: glycosylasparaginase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110057#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.5.1.26
fast: false
modifier: MODEL1310110057#
is: SBO:0000176

metaM Lcystin c
has only substance units: false
name: L-cystine
is: HMDB00192
boundary condition: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: CHEBI:16283

http://identifiers.org/biomodels.db/MODEL1310110057#_561c5a48_a4b7_42ba_850f_765802ca5bc6
name: INPP5E
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:56623
boundary condition: true
has only substance units: false
is: Q9NRR6
constant: false

metaR FAOXC5C5DCc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of glutaryl carnitine
type: Reaction

metaR PHYTt
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
product: MODEL1310110057#
name: fatty acid transport via diffusion
kinetic law: MODEL1310110057#
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110057#

metaM accoa n
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
boundary condition: false
has only substance units: false
name: acetyl-CoA(4-)
type: Species
is: CHEBI:57288
initial amount: NaN
initial concentration: 1.0
is: HMDB01206
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_5ef282fc_2b7c_4525_b897_6664ba4ff748
constant: false
type: Species
is: SBO:0000252
is: Q86YU0
has only substance units: false
name: CA7
is encoded by: hsa:766
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR TAURt4 2 r
modifier: MODEL1310110057#
type: Reaction
name: taurine transport (sodium symport) (2:1)
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
reactant: MODEL1310110057#
is described by: ECO:0000269

metaR HDCACBP
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR r2377
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false

metaR r0084
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
modifier: MODEL1310110057#
reversible: true
fast: false
is: SBO:0000176
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.1.1.42
reactant: MODEL1310110057#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_metaM_galacglc13galacglcgal14acglcgalgluside_hs_g
has only substance units: false
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0
constant: false
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: nLc8Cer
is: CHEBI:26174
initial amount: NaN

metaR 5HLTDL
reversible: false
is: SBO:0000176
type: Reaction
product: MODEL1310110057#
name: 5-Hydroxy-L-tryptophan decarboxy-lyase
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:1540578 NOTES:SAB
is described by: ECO:0000269
modifier: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.28

metaM xylu L c
has only substance units: false
is: CHEBI:17399
boundary condition: false
is: SBO:0000247
is: HMDB00751
initial amount: NaN
name: L-xylulose
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
constant: false
type: Species

metaR PMTCOAFABP1tc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of palmitoyl coA into the enterocytes
type: Reaction

metaR GALACGLCGALGBSIDEtg
type: Reaction
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000000
name: galacglcgalgbside hs intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
fast: false
is: SBO:0000185

metaR 3SALATAim
modifier: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: false
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial
fast: false
is: SBO:0000176
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.6.1.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_2cd41b65_0c75_4058_a699_962224aed10f
is encoded by: hsa:7355
constant: false
has only substance units: false
is: P78381
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: SLC35A2

metaM accoa m
boundary condition: false
type: Species
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
name: Acetyl-CoA
initial amount: NaN
is: HMDB01206
is: CHEBI:57288
is: C00024
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0

metaR ACNACNGALGBSIDEtg
is described by: ECO:0000000
name: acnacngalgbside hs intracellular transport
kinetic law: MODEL1310110057#
product: MODEL1310110057#
fast: false
reversible: true
reactant: MODEL1310110057#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

metaR RE0691C
is: SBO:0000176
name: RE0691
fast: false
reactant: MODEL1310110057#
is described by: ECO:0000000
product: MODEL1310110057#
reversible: true
type: Reaction
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR DGULND
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
type: Reaction
fast: false
is: SBO:0000176
reversible: true
reactant: MODEL1310110057#
name: dehydro-L-gulonate decarboxylase

metaR PI4PLCn
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.11
is described by: ECO:0000269
kinetic law: MODEL1310110057#
type: Reaction
name: phosphatidylinositol 4-phosphate phospholipase C, nucleus
modifier: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
is: SBO:0000176
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD

metaM man l
is: SBO:0000247
is: HMDB00169
is: CHEBI:16024
initial amount: NaN
constant: false
type: Species
name: D-mannose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
boundary condition: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110057#_d11bb9cb_8537_433a_ae0d_bb0658d396e7
initial concentration: NaN
is encoded by: hsa:56301
boundary condition: true
constant: false
is: SBO:0000252
name: SLC7A10
is: Q9NS82
has only substance units: false
type: Species
initial amount: NaN

metaR r1665
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110057#
name: Y+LAT2 Utilized transport
product: MODEL1310110057#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_e21bedc0_5b22_4c2d_a883_84fd45d389d7
is: B3KUK6
initial concentration: NaN
name: NT5C1B
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:93034
has only substance units: false

metaM HC01842 c
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:31997
name: Phosphodimethylethanolamine

metaM malttr e
is: HMDB01262
initial concentration: 1.0
type: Species
has only substance units: false
is: C01835
constant: false
is: CHEBI:27931
boundary condition: false
is: SBO:0000247
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
initial amount: NaN
name: maltotriose

metaR NOt
product: MODEL1310110057#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: NO transport (diffusion)
type: Reaction
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_c9dcba6f_a59f_47c6_a2ad_0cdc4cc266f4
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
name: _C7orf24_1_m
is encoded by: hsa:C7orf24

metaR AG13T9g
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_081d9d18_6734_4f2e_bdc2_d5b85ac5f31e
is: SBO:0000252
is: E9PDD5
has only substance units: false
initial amount: NaN
name: IDH3G
is encoded by: hsa:3421
constant: false
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_f3ea749e_1dd2_4d16_ba89_1527aabe5c16
is: SBO:0000252
constant: false
is encoded by: hsa:4357
has only substance units: false
boundary condition: true
is: P25325
initial amount: NaN
type: Species
initial concentration: NaN
name: MPST

http://identifiers.org/biomodels.db/MODEL1310110057#_c2974551_ed9e_4fa3_90e4_0a8b6bc0d4cb
is: Q674R7
is: SBO:0000252
boundary condition: true
has only substance units: false
name: ATG9B
initial amount: NaN
type: Species
is encoded by: hsa:285973
constant: false
initial concentration: NaN

metaM 10fthf c
constant: false
is: C00234
boundary condition: false
name: 10-Formyltetrahydrofolate
has only substance units: false
is: HMDB00972
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial amount: NaN

metaM abt e
type: Species
name: L-arabinitol
has only substance units: false
is: HMDB01851
is: CHEBI:18403
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM 3dpdhb me m
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:50776
initial amount: NaN
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate
notes: FORMULA: C58H87O4 CHARGE: -1 INCHI: InChI=1S/C58H88O4/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58(60)61)43-56(62-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43,59H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3,(H,60,61)/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+

metaM nadph c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00221
constant: false
is: CHEBI:57783
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: C00005
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_9dcd16f1_4473_4f72_8f56_fe7ffcbd8e4e
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: PDE1C
constant: false
has only substance units: false
is encoded by: hsa:5137
is: Q8NB10
initial amount: NaN
type: Species

metaM glu5p m
notes: FORMULA: C5H8NO7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01092 EHMN_ABBREVIATION: C03287
constant: false
boundary condition: false
is: SBO:0000247
name: L-Glutamate 5-phosphate
initial concentration: 1.0
is: HMDB01228
initial amount: NaN
has only substance units: false
is: CHEBI:58274
type: Species

metaR ETFQO
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.5.1
fast: false
reversible: false
product: MODEL1310110057#
is described by: ECO:0000000
type: Reaction
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
modifier: MODEL1310110057#

metaR XOL27OHtm
kinetic law: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
is: SBO:0000185
product: MODEL1310110057#
name: 27 hydroxy cholesterol transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
fast: false
is described by: ECO:0000000

metaM Rtotal c
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB01448
is: SBO:0000247
is: CHEBI:16189
notes: FORMULA: CO2FULLR CHARGE: -1
constant: false
boundary condition: false
has only substance units: false
name: R total

metaR r1664
name: Y+LAT2 Utilized transport
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110057#
reactant: MODEL1310110057#
reversible: true
product: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM gar c
initial concentration: 1.0
name: N1-(5-Phospho-D-ribosyl)glycinamide
is: SBO:0000247
type: Species
is: HMDB02022
boundary condition: false
has only substance units: false
is: C03838
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
constant: false
is: CHEBI:58457
initial amount: NaN

metaR NADPtxu
kinetic law: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
name: NADP transporter, peroxisome
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ potential for free H NJ
reversible: false
is: SBO:0000185
product: MODEL1310110057#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110057#_metaM_galacglcgalacglcgal14acglcgalgluside_hs_g
boundary condition: false
is: CHEBI:26174
name: I-antigen
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_967d0c7a_77c3_4cdc_9f2f_bbd3115c4a7b
is: P09417
constant: false
name: QDPR
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:5860

metaM 4hexdtetcoa m
boundary condition: false
initial concentration: 1.0
name: 4,7,10,13-hexadecatetraenoylcoa
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: HMDB02288
type: Species

metaR NAt5
kinetic law: MODEL1310110057#
type: Reaction
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (6548.1) or (6550.1) or (6549.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:8199403,PMID:8595899 NOTES:NCD
name: sodium/ammonium proton antiporter
is described by: ECO:0000269
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110057#
reactant: MODEL1310110057#

metaM vacccoa m
is: http://identifiers.org/pubchem.compound/9543677
has only substance units: false
name: vaccenyl coenzyme A
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB06521
is: SBO:0000247
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1

metaM ei11ecoa x
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
name: 11-eicosenoylcoa
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790

metaR r1667
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110057#
name: Y+LAT2 Utilized transport
type: Reaction
reversible: true
product: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false

metaR FAOXC61C4m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

metaR GGH 7DHFe
name: Gamma-glutamyl hydrolase (7DHF), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110057#
reversible: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
product: MODEL1310110057#
modifier: MODEL1310110057#
fast: false

metaR r1453
reversible: true
kinetic law: MODEL1310110057#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
reactant: MODEL1310110057#
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_e7ea71dd_1e4a_4e60_9bf7_0b80a83825fe
name: HADHA
initial concentration: NaN
is encoded by: hsa:3030
is: E9KL44
type: Species
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

metaM dhea c
has only substance units: false
type: Species
is: HMDB00077
is: CHEBI:28689
initial amount: NaN
boundary condition: false
name: 3beta-hydroxyandrost-5-en-17-one
constant: false
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_76d768dc_efe6_4f8a_bb4f_c8ecda468a92
constant: false
initial concentration: NaN
is: P33316
boundary condition: true
has only substance units: false
initial amount: NaN
name: DUT
is encoded by: hsa:1854
type: Species
is: SBO:0000252

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaR UDPG4E
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
name: UDPglucose 4-epimerase
type: Reaction
is: SBO:0000176
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/5.1.3.2
modifier: MODEL1310110057#
is described by: ECO:0000134

metaM gthox m
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
constant: false
initial amount: NaN
is: HMDB03337
boundary condition: false
is: CHEBI:58297
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species

metaM CE0785 m
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
type: Species
is: CHEBI:57795
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
name: cis,cis-myristo-5,8-dienoyl-CoA
initial concentration: 1.0

metaM ksi deg21 l
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
boundary condition: false
initial concentration: 1.0
is: CHEBI:12936
name: keratan sulfate I, degradation product 21
is: HMDB00143

metaR CORE3GTg
modifier: MODEL1310110057#
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110057#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110057#
fast: false
is: SBO:0000176
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
reversible: false

metaR SUBEACTD
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberic acid into cytosol (diffusion)
type: Reaction

metaM s2l2n2m2masn e
is: CHEBI:3554
boundary condition: false
is: HMDB00244
name: de-Fuc form of PA6
notes: FORMULA: C84H135N6O61X CHARGE: -2
has only substance units: false
initial amount: NaN
type: Species
is: C00255
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM 4hpro LT m
has only substance units: false
is: CHEBI:18095
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: trans-4-hydroxy-L-proline
boundary condition: false
is: HMDB00725
constant: false

metaR FAOXC143C123m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

metaR r1666
product: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110057#
name: Y+LAT2 Utilized transport
type: Reaction
reversible: true
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110057#_cbd7cb45_ee48_413b_8767_3a1474215c57
has only substance units: false
is: C9JZ62
initial concentration: NaN
constant: false
is encoded by: hsa:641649
initial amount: NaN
boundary condition: true
name: TMEM91
is: SBO:0000252
type: Species

metaM Rtotal e
name: R total
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:3554
notes: FORMULA: CO2FULLR CHARGE: -1
is: C00255
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00244
has only substance units: false

metaR FACOAL224
is described by: ECO:0000000
name: fatty-acid--CoA ligase
product: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110057#
reversible: true
is: SBO:0000176

metaM paf hs e
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:36707
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false

metaR r0081
reactant: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
type: Reaction
fast: false
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
is described by: ECO:0000000
reversible: true
is: SBO:0000176
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.5.1.12

metaR RE3627M
is: SBO:0000176
reactant: MODEL1310110057#
product: MODEL1310110057#
reversible: true
name: RE3627
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
type: Reaction
kinetic law: MODEL1310110057#

metaM xyl D l
name: aldehydo-D-xylose
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
is: CHEBI:15936
constant: false

metaM dlnlcgcoa c
has only substance units: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:27979
initial amount: NaN
type: Species
name: dihomo-gamma-linolenyl coenzyme A

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR EX 34dhoxpeg LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxyphenylethyleneglycol exchange
type: Reaction

metaM bildglcur r
is: SBO:0000247
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
type: Species
constant: false
is: HMDB03325
boundary condition: false
name: bis(beta-glucosyluronate)bilirubin
initial concentration: 1.0
is: CHEBI:58471
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_6b06670e_fe22_4082_b844_ec1cd49fbf52
name: _R33828_1_c
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:R33828
initial amount: NaN
constant: false
type: Species
boundary condition: true

metaM HC00718 c
has only substance units: false
is: SBO:0000247
name: N-methylethanolaminium phosphate(1-)
is: CHEBI:57781
initial amount: NaN
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
type: Species
constant: false
initial concentration: 1.0
boundary condition: false

metaM pcrn x
has only substance units: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: HMDB00824
boundary condition: false
name: propionyl-carnitine
is: http://identifiers.org/pubchem.compound/107738
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
initial amount: NaN

metaR HSD11B1r
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (3290.2) or (3290.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.146 Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
is: SBO:0000176
reversible: true
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.1.1.146
type: Reaction
fast: false
product: MODEL1310110057#
is described by: ECO:0000269
name: 11-beta-hydroxysteroid dehydrogenase type 1
kinetic law: MODEL1310110057#

metaR r1661
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110057#
reversible: true
reactant: MODEL1310110057#
is described by: ECO:0000000
modifier: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR HGNTOR
reversible: false
type: Reaction
modifier: MODEL1310110057#
fast: false
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.13.11.5
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110057#

metaM gluside hs g
boundary condition: false
is: CHEBI:18368
constant: false
initial amount: NaN
type: Species
name: D-glucosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_0c88fb49_d166_4831_96d9_1cb087dc00cb
name: NDUFB10
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:4716
is: A8K761

metaR PROt4 2 r
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
product: MODEL1310110057#
name: Proline transport (sodium symport) (2:1)
fast: false
is described by: ECO:0000006
reactant: MODEL1310110057#
is: SBO:0000185
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction

metaM acnam c
initial concentration: 1.0
has only substance units: false
name: N-acetylneuraminate
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00230
initial amount: NaN
is: CHEBI:35418
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_f87f67a9_a2d7_4400_a8a4_71ec5767d070
initial amount: NaN
is: Q99624
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:10991
boundary condition: true
is: SBO:0000252
type: Species
name: SLC38A3

http://identifiers.org/biomodels.db/MODEL1310110057#_e368453a_c06b_4170_b868_ba1ea8a46026
is encoded by: hsa:34
name: ACADM
is: P11310
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false

metaM mev R x
initial concentration: 1.0
is: HMDB00227
has only substance units: false
is: CHEBI:36464
initial amount: NaN
constant: false
name: (R)-mevalonate
type: Species
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
boundary condition: false
is: SBO:0000247

metaR FACOAL160i
type: Reaction
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
is described by: ECO:0000269
kinetic law: MODEL1310110057#
name: C160 fatty acid activation
is: SBO:0000176
reversible: false
product: MODEL1310110057#
fast: false
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_e65fbebc_e330_4b71_874e_35c10b5aaac7
is encoded by: hsa:125
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: P00325
has only substance units: false
name: ADH1B

metaR MEVK1x
is version of: http://identifiers.org/ec-code/2.7.1.36
name: mevalonate kinase (atp)
kinetic law: MODEL1310110057#
fast: false
modifier: MODEL1310110057#
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
reversible: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.1.36 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version NJ
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_d7e07ac0_3a78_44b3_af92_1badcaad5162
is encoded by: hsa:2517
is: SBO:0000252
boundary condition: true
type: Species
name: FUCA1
constant: false
is: P04066
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

metaR LEUTA
is version of: http://identifiers.org/ec-code/2.6.1.42
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
name: leucine transaminase
is: SBO:0000176
is described by: ECO:0000269
reversible: true
product: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction
modifier: MODEL1310110057#

metaR ITPtn
product: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
reactant: MODEL1310110057#
name: ITP nuclear transport
fast: false

metaR r1660
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110057#

metaR FACOAL226
name: fatty-acid--CoA ligase
is described by: ECO:0000000
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
kinetic law: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is: SBO:0000176
fast: false

metaR r0156
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
kinetic law: MODEL1310110057#
product: MODEL1310110057#
fast: false
reversible: false
modifier: MODEL1310110057#
type: Reaction
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is described by: ECO:0000000
reactant: MODEL1310110057#
is: SBO:0000176

metaM fe2 e
is: SBO:0000247
is: HMDB00692
is: CHEBI:29033
initial amount: NaN
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: C00023
name: Fe2+
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
has only substance units: false

metaR ASNGLNNaEx
is: SBO:0000185
fast: false
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)
modifier: MODEL1310110057#
type: Reaction
reversible: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000269
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

http://identifiers.org/biomodels.db/MODEL1310110057#_6b74125c_8c3e_48d9_9bfe_f4ccdc06bdfd
initial amount: NaN
has only substance units: false
name: ESCO2
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:157570
initial concentration: NaN
is: Q56NI9
type: Species

metaM lnlccrn c
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: Linoleyl carnitine
type: Species
is: HMDB06469
initial amount: NaN
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_260fceb9_841d_4155_86ef_28235f19abc4
has only substance units: false
is encoded by: hsa:79087
is: SBO:0000252
is: Q9BV10
name: ALG12
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_62f8693c_bf62_426f_bae4_2a7f9f943403
initial concentration: NaN
boundary condition: true
is encoded by: hsa:26290
constant: false
type: Species
name: GALNT8
is: Q9NY28
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_04660fd9_7a99_4734_8aa5_82b9bace31d9
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: P00338
constant: false
type: Species
is encoded by: hsa:3939
has only substance units: false
name: LDHA
initial amount: NaN

metaM dadp m
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:57667
has only substance units: false
type: Species
is: HMDB01508
initial amount: NaN
constant: false
name: dADP(3-)

http://identifiers.org/biomodels.db/MODEL1310110057#_afffa083_cf37_4de4_a596_ee0144eb1552
type: Species
has only substance units: false
name: B3GNT2
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10678
initial amount: NaN

metaR r0157
is: SBO:0000176
fast: false
product: MODEL1310110057#
kinetic law: MODEL1310110057#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
reversible: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
is version of: http://identifiers.org/ec-code/6.3.4.2
type: Reaction
modifier: MODEL1310110057#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110057#_5f4039a8_5a51_4369_8620_5ae0533ff74d
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
name: ALG3
constant: false
is encoded by: hsa:10195
has only substance units: false

metaM adrncoa x
name: adrenyl coenzyme A
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205480
type: Species
is: C16170
has only substance units: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: SBO:0000247
constant: false
boundary condition: false

metaR LEUyLAThtc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_221e2ca2_6811_4555_90d9_002477a33441
is: Q546E0
constant: false
is: SBO:0000252
is encoded by: hsa:2530
name: FUT8
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false

metaR DCYTt
reactant: MODEL1310110057#
reversible: true
kinetic law: MODEL1310110057#
name: deoxycytidine transport via diffusion
is: SBO:0000185
product: MODEL1310110057#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_e40d3dac_1b22_425f_8e38_388036662227
has only substance units: false
name: ACSL5
initial concentration: NaN
is: Q9ULC5
constant: false
is encoded by: hsa:51703
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252

metaR AG13T18g
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110057#
is: SBO:0000176
product: MODEL1310110057#
reversible: false
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_80aab5ec_d613_443e_899b_6389b12cc8c8
is: SBO:0000252
constant: false
initial concentration: NaN
name: ACO1
boundary condition: true
initial amount: NaN
is encoded by: hsa:48
type: Species
has only substance units: false
is: P21399

metaM 10fthf e
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: HMDB00972
type: Species
boundary condition: false
has only substance units: false
name: 10-formyltetrahydrofolate(2-)
initial amount: NaN
constant: false
is: CHEBI:57454
is: SBO:0000247

metaM 2decdicoa m
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/16019966
name: 2,7-decadienoylcoa
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false

metaR C14STRr
name: C-14 sterol reductase
type: Reaction
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.3.1.70
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ

metaM 3tetd7ecoacrn e
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: 3-hydroxy tetradecenoyl-7-carnitine
initial amount: NaN
notes: FORMULA: C21H39NO5 CHARGE: 0
is: HMDB02014
constant: false

metaM man g
is: HMDB00169
name: D-mannose
constant: false
has only substance units: false
type: Species
is: CHEBI:16024
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial amount: NaN
is: SBO:0000247

metaR ALOX52
modifier: MODEL1310110057#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
reversible: false
name: Arachidonate 5-lipoxygenase
is version of: http://identifiers.org/ec-code/1.13.11.34
is: SBO:0000176
fast: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_26d405be_a269_49d1_a356_fa3e9c2eebbf
boundary condition: true
is: SBO:0000252
name: PDE7A
has only substance units: false
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5150

metaM for e
is: HMDB00142
is: SBO:0000247
constant: false
name: formate
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:15740
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
has only substance units: false

metaM dadp n
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:57667
type: Species
is: HMDB01508
name: dADP(3-)
has only substance units: false
initial amount: NaN
constant: false

metaR r1662
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110057#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#

metaM 2hexdtricoa x
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
is: HMDB02288
initial amount: NaN
constant: false
initial concentration: 1.0
name: 2,7,10-hexadecatrienoylcoa
has only substance units: false
boundary condition: false

metaM 4nphsf e
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB06492
initial amount: NaN
boundary condition: false
name: 4-Nitrophenyl sulfate
constant: false
initial concentration: 1.0
is: CHEBI:35422
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)

metaM fe2 c
is: C00023
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: HMDB00692
initial concentration: 1.0
is: CHEBI:29033
name: Fe2+

metaM accoa x
has only substance units: false
is: C00024
is: HMDB01206
type: Species
initial concentration: 1.0
is: CHEBI:57288
boundary condition: false
is: SBO:0000247
name: Acetyl-CoA
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_a00f9400_4c0b_4353_a415_006c8657955d
name: _N63787_1_c
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:N63787
boundary condition: true
is: SBO:0000252
type: Species

metaM 3mox4hpac m
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB05175
boundary condition: false
is: CHEBI:28111
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
initial amount: NaN
type: Species
has only substance units: false

metaM 4hpro LT e
name: trans-4-hydroxy-L-proline
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00725

metaR HDCEAtr
product: MODEL1310110057#
name: fatty acid transport via diffusion
reactant: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true

metaR CYTK8
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
reversible: true
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110057#
name: cytidylate kinase (CMP,dATP)
modifier: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false

metaM arg L c
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:32682
type: Species
is: HMDB00517
boundary condition: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial amount: NaN
name: L-argininium(1+)

http://identifiers.org/biomodels.db/MODEL1310110057#_2d0c396c_ef8f_4ef0_a7ed_9acfc8e15537
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:27068
name: PPA2
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_384b9ca1_f060_429b_bd14_39f2ad91fd3d
name: _W74642_1_c
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:W74642
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR GLNTHRNaEx
name: L-threonine/L-glutamine Na-dependent exchange (Gln-L in)
is: SBO:0000185
modifier: MODEL1310110057#
reversible: false
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaM vacccoa c
initial amount: NaN
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/9543677
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
is: HMDB06521
name: vaccenyl coenzyme A
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_d9e4a0ab_e20f_4235_b9b3_2d74afebe8e8
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaR CHSTEROLt1
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction
name: cholesterol intracellular transport
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
fast: false
is: SBO:0000185
product: MODEL1310110057#
reversible: true
modifier: MODEL1310110057#
is described by: ECO:0000304

metaM CE5236 c
boundary condition: false
is: CHEBI:28002
is: SBO:0000247
name: O2'-4a-cyclic-tetrahydrobiopterin
has only substance units: false
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
constant: false
is: HMDB03952
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_d5c8f501_9a48_4d91_a1b9_2d5174fc6d82
boundary condition: true
is: SBO:0000252
has only substance units: false
name: ATP5C1
is encoded by: hsa:509
initial amount: NaN
type: Species
is: Q6I9V2
initial concentration: NaN
constant: false

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_0ead3538_a4d9_4fc1_8bc9_d43201d88fb9
initial amount: NaN
is encoded by: hsa:H17063
type: Species
boundary condition: true
name: _H17063_1_m
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_6bd96748_e657_4ad9_a8f8_4dfcd86e30a7
name: ACLY
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:47
boundary condition: true
initial amount: NaN
is: P53396
type: Species

metaR CYTK7
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110057#
is: SBO:0000176
reactant: MODEL1310110057#
name: cytidylate kinase (CMP,UTP)
reversible: true
modifier: MODEL1310110057#
fast: false
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_a2657818_487f_4852_b990_8e3ca27d8842
initial amount: NaN
is: Q16762
name: TST
type: Species
is: SBO:0000252
is encoded by: hsa:7263
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaM gpail hs c
boundary condition: false
is: CHEBI:17049
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
has only substance units: false
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_2614551f_fa6f_4ff4_aed9_473561650f2e
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:57835
initial amount: NaN
is: SBO:0000252
name: SLC4A5
type: Species

metaR CSNATr
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
reactant: MODEL1310110057#
type: Reaction
is described by: ECO:0000000
name: carnitine O-acetyltransferase
kinetic law: MODEL1310110057#
fast: false
is: SBO:0000176
product: MODEL1310110057#
reversible: true

metaR CHSTEROLt2
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: true
name: cholesterol intracellular transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fast: false
is: SBO:0000185
product: MODEL1310110057#
type: Reaction

metaM odecoa c
initial concentration: 1.0
name: Octadecenoyl-CoA (n-C18:1CoA)
is: CHEBI:3793
constant: false
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: HMDB01322
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_1ae50c62_c509_4bde_ad46_b6dc275b9b01
has only substance units: false
initial concentration: NaN
name: IDH1
is encoded by: hsa:3417
initial amount: NaN
is: O75874
type: Species
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_ad686736_ff5e_443e_ab1a_051d95bfa34d
initial concentration: NaN
is: Q99714
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:3028
name: HSD17B10

metaM adp c
is: http://identifiers.org/pubchem.compound/3310
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
is: C00008
is: CHEBI:16761
initial amount: NaN
has only substance units: false
name: ADP
is: HMDB01341

metaR CYTK6
reactant: MODEL1310110057#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110057#
fast: false
reversible: true
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,CTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269

metaM 4hpro LT c
constant: false
type: Species
is: HMDB00725
boundary condition: false
initial amount: NaN
has only substance units: false
name: trans-4-hydroxy-L-proline
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:18095
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690

metaM s2l2n2m2masn l
notes: FORMULA: C84H135N6O61X CHARGE: -2
has only substance units: false
initial concentration: 1.0
is: CHEBI:18287
is: SBO:0000247
type: Species
is: HMDB00174
name: de-Fuc form of PA6
constant: false
initial amount: NaN
boundary condition: false

metaR FATP3t
reactant: MODEL1310110057#
is described by: ECO:0000269
is: SBO:0000185
reversible: true
fast: false
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
product: MODEL1310110057#
type: Reaction
name: fatty acid electroneutral transport

metaM arg L e
is: CHEBI:32682
type: Species
name: L-argininium(1+)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
has only substance units: false
is: HMDB00517

metaM for r
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
name: Formate
is: C00058
constant: false
initial concentration: 1.0
is: CHEBI:15740
type: Species
is: HMDB00142
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110057#_f99b232f_a465_4692_a482_3ca7d6c86796
has part: B4DY56
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
constant: false
initial amount: NaN
is: SBO:0000297
type: Species
is encoded by: hsa:498
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM gluside hs r
has only substance units: false
type: Species
is: SBO:0000247
name: D-glucosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial concentration: 1.0
initial amount: NaN
is: CHEBI:18368
constant: false
boundary condition: false

metaM xyl D e
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
is: CHEBI:15936
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
name: aldehydo-D-xylose
has only substance units: false

metaR VD3
reactant: MODEL1310110057#
fast: false
product: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000134
name: Vitamin D3 formation
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT

http://identifiers.org/biomodels.db/MODEL1310110057#_0574677f_3e0e_4a9f_ba28_e47435252c4a
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5334
type: Species
constant: false
boundary condition: true
initial concentration: NaN
name: PLCL1
initial amount: NaN
is: Q15111

metaR ESTRADIOLtr
reversible: true
fast: false
kinetic law: MODEL1310110057#
name: estradiol intracellular transport
reactant: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

http://identifiers.org/biomodels.db/MODEL1310110057#_metaM_fucgalacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
name: VI2Fuc-nLc6
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C64H112N3O36FULLRCO CHARGE: 0
is: CHEBI:61648
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_dfd8634e_be84_4cbf_b2bd_5226bffea551
has only substance units: false
name: SLC4A10
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:57282
initial concentration: NaN
constant: false
is: B7Z1R0

http://identifiers.org/biomodels.db/MODEL1310110057#_cb8441f1_647a_45e3_ac44_bf408f00cfa6
initial concentration: NaN
is: P04075
is encoded by: hsa:226
boundary condition: true
initial amount: NaN
name: ALDOA
is: SBO:0000252
constant: false
has only substance units: false
type: Species

metaR CYTK5
name: cytidylate kinase (dCMP)
modifier: MODEL1310110057#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
reversible: true
reactant: MODEL1310110057#
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR GCHOLAte
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110057#
name: bile acid intracellular transport
reactant: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaM sucr e
is: C00089
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: Sucrose
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00091 EHMN_ABBREVIATION: C00089
has only substance units: false
is: HMDB00258
constant: false
type: Species
boundary condition: false
is: CHEBI:17992

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR PROSTGE2t
reactant: MODEL1310110057#
is: SBO:0000185
modifier: MODEL1310110057#
type: Reaction
fast: false
kinetic law: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
product: MODEL1310110057#
name: prostaglandin transport via bicarbonate countertransport

metaR CSNATp
is version of: http://identifiers.org/ec-code/2.3.1.7
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
fast: false
product: MODEL1310110057#
reversible: true
is: SBO:0000176
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110057#_19473121_a285_4461_85a9_970d60f031ae
is: Q8IWU9
boundary condition: true
name: TPH2
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:121278

metaR CYTK4
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110057#
is: SBO:0000176
modifier: MODEL1310110057#
name: cytidylate kinase (dCMP)(GTP)
reversible: true
kinetic law: MODEL1310110057#
fast: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.3

metaM adp e
constant: false
is: HMDB01341
is: CHEBI:456216
type: Species
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial amount: NaN
name: ADP(3-)
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM chtn e
boundary condition: false
constant: false
is: CHEBI:17029
is: SBO:0000247
type: Species
notes: FORMULA: C24H41N3O16 CHARGE: 0 INCHI: InChI=1S/C24H41N3O16/c1-7(31)25-13-18(36)20(11(5-29)39-22(13)38)42-24-15(27-9(3)33)19(37)21(12(6-30)41-24)43-23-14(26-8(2)32)17(35)16(34)10(4-28)40-23/h10-24,28-30,34-38H,4-6H2,1-3H3,(H,25,31)(H,26,32)(H,27,33)/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+,24+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02118
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: chitin
is: HMDB03362

http://identifiers.org/biomodels.db/MODEL1310110057#_551fc3a3_d0c6_4309_8771_77fb6b9e0785
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: ALG2
initial concentration: NaN
constant: false
is encoded by: hsa:85365

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaM ins c
is: SBO:0000247
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00195
name: Inosine
constant: false
boundary condition: false
is: C00294
is: CHEBI:17596
initial concentration: 1.0

metaR r1669
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110057#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110057#
is: SBO:0000185
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110057#

metaR LNLCCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
kinetic law: MODEL1310110057#
name: carnitine O-palmitoyltransferase
is described by: ECO:0000269
is: SBO:0000176
fast: false
reactant: MODEL1310110057#
product: MODEL1310110057#

metaM octdececrn m
notes: FORMULA: C25H47NO4 CHARGE: 0
is: SBO:0000247
constant: false
type: Species
has only substance units: false
boundary condition: false
is: HMDB06351
initial concentration: 1.0
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
initial amount: NaN

metaM ksi pre19 g
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 19
is: CHEBI:58053
boundary condition: false
is: SBO:0000247
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
initial amount: NaN
type: Species
is: HMDB00175
has only substance units: false
constant: false
is: C00130

metaR CYTK3
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110057#
reversible: true
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
modifier: MODEL1310110057#
name: cytidylate kinase (CMP)(GTP)
type: Reaction
fast: false
product: MODEL1310110057#

metaM paf hs c
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
boundary condition: false
initial concentration: 1.0
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
is: CHEBI:36707
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
type: Species

metaR SERGLNNaEx
type: Reaction
reactant: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
name: L-serine/L-glutamine Na-dependent exchange (Ser-L in)
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
is: SBO:0000185
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110057#_1e1cb56e_672d_417b_8b32_993393ce3e31
is: SBO:0000252
name: OGDHL
is encoded by: hsa:55753
type: Species
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q9ULD0

http://identifiers.org/biomodels.db/MODEL1310110057#_8a9b0e72_90e6_47e8_848d_77e832a14e1e
is encoded by: hsa:126
has part: P00326
name: ADH1A:ADH1C
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000297
boundary condition: true

metaM dopasf c
is: HMDB06275
name: dopamine 3-O-sulfate
initial amount: NaN
is: SBO:0000247
is: CHEBI:37946
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690

metaR PAFH
product: MODEL1310110057#
fast: false
type: Reaction
modifier: MODEL1310110057#
is: SBO:0000176
reversible: false
name: Platelet-activating factor acetylhydrolase
is described by: ECO:0000269
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (5051.1) or (5049.1 and 5050.1) or (5049.1 and 5050.1 and 5048.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:7669037,PMID:8028668,PMID:8955149 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.1.47
kinetic law: MODEL1310110057#

metaR LNLCCPT2
reactant: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
reversible: false
name: carnitine transferase
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
fast: false

metaR r1668
kinetic law: MODEL1310110057#
is: SBO:0000185
modifier: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110057#

metaM man r
initial concentration: 1.0
is: HMDB00169
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false
is: CHEBI:16024
boundary condition: false
is: SBO:0000247
name: D-mannose
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_c86c04cd_dc99_419c_9ce6_2c634d6bc5a4
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: _AA629629_1_m
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:AA629629

http://identifiers.org/biomodels.db/MODEL1310110057#_72fd41f3_1d84_4b2d_aba1_5efdd21991e2
name: SLC12A4
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is: F5H066
has only substance units: false
is encoded by: hsa:6560

metaM tdcrn e
is: HMDB05066
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: myristoyl carnitine
has only substance units: false
notes: FORMULA: C21H41NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110057#_730960c7_b302_49e7_a7b0_4251280774ad
has only substance units: false
is: SBO:0000252
is encoded by: hsa:26503
initial amount: NaN
name: SLC17A5
is: Q9NRA2
boundary condition: true
initial concentration: NaN
type: Species
constant: false

metaR C12DCACOT
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of dodecanedioyl coa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_796f6003_e654_4697_be95_4819a67823d4
name: NDUFA7
type: Species
is encoded by: hsa:4701
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q6FG42
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_1e654c0d_907a_47aa_914f_9241f3c17706
is: Q9NZJ6
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:51805
boundary condition: true
name: COQ3
is: SBO:0000252
type: Species

metaR CYTK2
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110057#
is: SBO:0000176
name: cytidylate kinase (dCMP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
product: MODEL1310110057#
fast: false
is described by: ECO:0000269

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_21a03e34_f99e_4906_a4c9_7ea14b5c4d0a
has only substance units: false
initial concentration: NaN
is encoded by: hsa:158
constant: false
initial amount: NaN
is: P30566
name: ADSL
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_3c10472f_2b55_4176_8745_7fbb38889b9f
is: SBO:0000252
name: AKR1D1
is encoded by: hsa:6718
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: P51857
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_9b8fe60a_19a0_45df_96ca_508b29f29829
is: P26572
name: MGAT1
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:4245
initial concentration: NaN

metaR CSNATm
name: carnitine O-aceyltransferase, mitochondrial
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
fast: false
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.3.1.7
kinetic law: MODEL1310110057#
is: SBO:0000176
reversible: true
product: MODEL1310110057#

metaR MMSAD3m
is version of: http://identifiers.org/ec-code/1.2.1.27
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
reversible: false
product: MODEL1310110057#
is: SBO:0000176
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD

metaR NACHEXA18ly
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110057#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is described by: ECO:0000000
is: SBO:0000176
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110057#
product: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#

metaR CHSTEROLt3
reactant: MODEL1310110057#
type: Reaction
reversible: true
is: SBO:0000185
name: cholesterol intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
product: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
is described by: ECO:0000000

metaR EX caro LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Carotene exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_11d0922f_2338_4473_9dfc_dcc4147252ff
type: Species
initial amount: NaN
is encoded by: hsa:477
is encoded by: hsa:23439
initial concentration: NaN
has part: Q9UN42
boundary condition: true
has only substance units: false
is: SBO:0000297
name: ATP1B4:ATP1A2
has part: P50993
constant: false

metaR LTD4DP
fast: false
reversible: true
is described by: ECO:0000000
name: Leukotriene D4 dipeptidase
kinetic law: MODEL1310110057#
is: SBO:0000176
product: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ

metaM ins e
constant: false
is: C00294
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: SBO:0000247
boundary condition: false
is: CHEBI:17596
type: Species
name: Inosine
has only substance units: false
initial amount: NaN
is: HMDB00195
initial concentration: 1.0

metaR CYTK1
fast: false
type: Reaction
name: cytidylate kinase (CMP)
kinetic law: MODEL1310110057#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#

metaM ksi deg32 l
type: Species
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I, degradation product 32
is: HMDB00143
is: SBO:0000247
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
constant: false
boundary condition: false
is: CHEBI:12936
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_4b7894f0_4c85_42d3_8c8d_37991b0d3c74
name: HAL
has only substance units: false
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:3034
initial concentration: NaN
is: B4E0V8
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_7c952045_018f_4770_bcd8_69c06cdc8921
constant: false
is encoded by: hsa:222
type: Species
is: P48448
name: ALDH3B2
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_9fc5837b_e330_4684_b945_3c4de28099db
is encoded by: hsa:516
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000297
type: Species
boundary condition: true
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
has part: Q6FIH7

metaR RE0944E
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.1
name: RE0944
product: MODEL1310110057#
is described by: ECO:0000000
reactant: MODEL1310110057#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.17
kinetic law: MODEL1310110057#
is: SBO:0000176
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reversible: true

metaM ksii core2 pre9 g
initial amount: NaN
is: SBO:0000247
constant: false
name: keratan sulfate II biosynthesis, precursor 9
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
is: CHEBI:28067
type: Species
boundary condition: false

metaM dopasf e
is: SBO:0000247
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
name: dopamine 3-O-sulfate
is: CHEBI:37946
constant: false
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB06275

metaM clpn hs c
constant: false
is: CHEBI:28494
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H16O9P2FULLRCO2FULLR2CO2FULLRCO2FULLR2CO2 CHARGE: -2
is: SBO:0000247
name: cardiolipin
type: Species
boundary condition: false

metaM tdcrn c
boundary condition: false
has only substance units: false
is: SBO:0000247
name: myristoyl carnitine
notes: FORMULA: C21H41NO4 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
is: HMDB05066
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_74da2753_f024_41e7_ad11_241152046070
is encoded by: hsa:55163
name: PNPO
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is: Q9NVS9
type: Species
boundary condition: true
initial concentration: NaN

metaR MG1er
fast: false
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110057#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.2.1.106
reversible: false
type: Reaction
reactant: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_7f3557d8_ba60_40ae_9d15_9a9a800c9540
is encoded by: hsa:84720
boundary condition: true
has part: Q8TEQ8
initial concentration: NaN
has part: Q07326
is encoded by: hsa:5281
name: PIGF:PIGO
has only substance units: false
is: SBO:0000297
initial amount: NaN
type: Species
constant: false

metaR XOL7AONEtr
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110057#

metaR r0936
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
product: MODEL1310110057#
is described by: ECO:0000000
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
name: Transport reaction
is: SBO:0000185

metaM ksi pre26 g
is: SBO:0000247
is: CHEBI:28067
constant: false
boundary condition: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 26
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C199H318N14O166S8X CHARGE: -9

metaR FATP9t
reversible: true
is: SBO:0000185
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/6.2.1.3
is version of: http://identifiers.org/ec-code/6.2.1.7
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reactant: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
is described by: ECO:0000269
name: fatty acid electroneutral transport

metaM cgly e
is: CHEBI:4047
has only substance units: false
is: HMDB00078
initial amount: NaN
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
name: L-cysteinylglycine
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR PACCOAL
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
name: phenylacetate-CoA ligase
reactant: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000000
fast: false

metaR ACGAMK
name: N-acetylglucosamine kinase
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110057#
reversible: false
type: Reaction
product: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.59

http://identifiers.org/biomodels.db/MODEL1310110057#_24c2b2da_54ba_41d7_8f71_fb6f3dec89b3
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:1962
type: Species
has only substance units: false
is: Q9NY65
initial concentration: NaN
name: EHHADH
boundary condition: true

metaR PI345P3P
is: SBO:0000176
modifier: MODEL1310110057#
type: Reaction
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.67
is described by: ECO:0000000
product: MODEL1310110057#
reversible: false

metaR AG13T8g
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
modifier: MODEL1310110057#
reactant: MODEL1310110057#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110057#
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110057#

metaR C180CRNt
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
is: SBO:0000185
kinetic law: MODEL1310110057#
name: C180 transport into the mitochondria
fast: false
type: Reaction
reversible: false
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000269

metaR COQ3m
modifier: MODEL1310110057#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110057#
reversible: false
is version of: http://identifiers.org/ec-code/2.1.1.114
is: SBO:0000176
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10777520,PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_2.1.1.114 IT
product: MODEL1310110057#
name: methyltransferase COQ3
type: Reaction
reactant: MODEL1310110057#

metaR FBA4
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (226.2) or (229.1) or (226.3) or (230.1) or (226.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.2.13 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
type: Reaction
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
reversible: true
is: SBO:0000176
modifier: MODEL1310110057#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.1.2.13
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_973ef54f_12a2_47dd_ab6a_53b67868dfd1
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:23657
has only substance units: false
name: SLC7A11
is: Q9UPY5

metaM 34dhoxmand c
has only substance units: false
is: HMDB01866
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: 3,4-Dihydroxymandelate
type: Species
is: CHEBI:27637
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580

http://identifiers.org/biomodels.db/MODEL1310110057#_af86c651_9c75_48c2_a04b_0a930c5dc474
boundary condition: true
is: Q9P019
type: Species
initial concentration: NaN
name: PHPT1
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:29085
constant: false

metaM dpcoa c
initial amount: NaN
has only substance units: false
is: C00882
type: Species
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:57328
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
name: Dephospho-CoA
is: HMDB01373
initial concentration: 1.0

metaM abt c
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:18403
is: SBO:0000247
name: L-arabinitol
type: Species
is: HMDB01851

metaR FE3MTP1
reversible: false
is described by: ECO:0000134
product: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
name: transport of ferrous iron into blood
modifier: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
fast: false

metaM cgly c
name: L-cysteinylglycine
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:4047
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
type: Species
is: HMDB00078
is: SBO:0000247
has only substance units: false

metaM hexdectecoa m
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB02288
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
boundary condition: false
name: 2,4,7,10-hexadecatetraenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110057#_6004242a_0e45_4711_a94b_f17adba55d0f
is: SBO:0000252
initial amount: NaN
name: NDUFB9
has only substance units: false
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:4715
is: Q9Y6M9

http://identifiers.org/biomodels.db/MODEL1310110057#_6dc5f800_f552_4c28_83ea_def8e58a28d5
is: SBO:0000252
boundary condition: true
is: Q8N3T1
name: GALNTL2
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:117248
initial amount: NaN

metaM hdd2coa m
has only substance units: false
name: trans-Hexadec-2-enoyl-CoA
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: CHEBI:61526
is: C05272
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB03945
boundary condition: false
constant: false

metaR TCYNTt
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reversible: false
name: Thiocyanate transport via diffusion (cytosol to extracellular)
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM

metaM galgalgalthcrm hs g
is: SBO:0000247
is: CHEBI:26174
boundary condition: false
initial amount: NaN
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
initial concentration: 1.0
constant: false
has only substance units: false
type: Species

metaM sucsal m
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
is: CHEBI:57706
is: HMDB01259
constant: false
has only substance units: false
name: Succinic semialdehyde
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR TAUBETAtc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by beta transport system
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_e8422db7_b259_40df_a1e0_eb6fd301ef5f
is: P09917
type: Species
is encoded by: hsa:240
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: ALOX5

metaR r0616
type: Reaction
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
fast: false
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
product: MODEL1310110057#

metaR BHBt
is: SBO:0000185
product: MODEL1310110057#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
name: (R)-3-Hydroxybutanoate transport via H+ symport
reactant: MODEL1310110057#
reversible: true
kinetic law: MODEL1310110057#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_871ba50a_25ac_4765_9b0c_73bf65a18a50
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
type: Species
is: O75752
is encoded by: hsa:8706
name: B3GALNT1

metaR NADS2
reactant: MODEL1310110057#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/6.3.5.1
type: Reaction
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: NAD synthase (glutamine-hydrolysing)
is: SBO:0000176
fast: false

metaM CE5236 n
is: HMDB03952
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: CHEBI:28002
is: SBO:0000247
has only substance units: false
name: O2'-4a-cyclic-tetrahydrobiopterin
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_05e7ea22_9172_4010_a7d8_e8805e7091a0
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3295
is: E9PB82
name: HSD17B4
boundary condition: true
constant: false
type: Species
has only substance units: false

metaR r0617
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
fast: false
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
reactant: MODEL1310110057#
type: Reaction
is: SBO:0000176
reversible: true

metaM duri n
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16450
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
boundary condition: false
name: 2'-deoxyuridine
is: SBO:0000247
type: Species
is: HMDB00012
constant: false
has only substance units: false

metaR r0937
name: Transport reaction
reversible: true
kinetic law: MODEL1310110057#
product: MODEL1310110057#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110057#

metaR FBA2
kinetic law: MODEL1310110057#
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD
modifier: MODEL1310110057#
type: Reaction
fast: false
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/4.1.2.13
is described by: ECO:0000304
is: SBO:0000176
reversible: true
product: MODEL1310110057#

metaR OCT11EFATP
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of vaccenic acid by cells
type: Reaction

metaR C160CPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
reversible: false
type: Reaction
modifier: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000269
product: MODEL1310110057#
name: C160 transport into the mitochondria

metaR r1527
reversible: false
fast: false
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/4.2.1.1
kinetic law: MODEL1310110057#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110057#_927630cf_1e40_4dd3_911c_968aa76adf9c
initial concentration: NaN
name: SLC6A8
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: B4DIA3
boundary condition: true
is encoded by: hsa:6535
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_38d70ccc_b341_4581_a762_dbf623ee8861
type: Species
has only substance units: false
initial concentration: NaN
is: O14561
name: NDUFAB1
is encoded by: hsa:4706
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252

metaR APOCFm
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
is described by: ECO:0000000
reversible: false
name: Apocarboxylase formation, mitochondrial
reactant: MODEL1310110057#
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110057#

metaR TDPm
product: MODEL1310110057#
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 2 AUTHORS: PMID:9755848 NOTES:_01-25-05 IT
name: thiamin pyrophosphatase, mitochondrial

metaR TPI
is described by: ECO:0000134
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.1.1
name: triose-phosphate isomerase
fast: false
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
reversible: true
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000176
modifier: MODEL1310110057#
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_1b3b2bd3_bd43_4c3c_8465_f9651759472c
is encoded by: hsa:2108
is: SBO:0000252
name: ETFA
is: P13804
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_b5aeed3d_909f_4680_9cf1_0b85188f5ac9
type: Species
initial amount: NaN
is encoded by: hsa:6821
name: SUOX
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
is: P51687

metaM thcholstoic x
is: SBO:0000247
type: Species
is: CHEBI:18402
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
constant: false
boundary condition: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
has only substance units: false
is: HMDB03873
initial concentration: 1.0
initial amount: NaN

metaM eicostetcoa c
type: Species
is: C16164
initial concentration: 1.0
initial amount: NaN
name: eicosatetranoyl coenzyme A
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1

metaR r0614
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
is: SBO:0000176
reversible: true
fast: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110057#
product: MODEL1310110057#
type: Reaction

metaR C160CPT1
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110057#
name: production of Palmitoylcarnitine
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000269
modifier: MODEL1310110057#
product: MODEL1310110057#

metaR ACGALtly
is described by: ECO:0000000
fast: false
product: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
reversible: false
reactant: MODEL1310110057#
name: N-acetyl-galactosamine lysosomal efflux
type: Reaction
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_35694768_78a4_4aa1_87c7_5f14bff103ee
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4833
name: NME4
is: O00746
constant: false

metaM ksi deg2 l
initial amount: NaN
constant: false
is: CHEBI:50570
name: keratan sulfate I, degradation product 2
notes: FORMULA: C241H384N17O210S12 CHARGE: -13
boundary condition: false
is: HMDB06529
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0

metaR ECOAH12m
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110057#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000304
product: MODEL1310110057#
reactant: MODEL1310110057#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
is: SBO:0000176

metaM c12dccoa c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: dodecanedioylcoa
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
constant: false
type: Species
is: HMDB00623

http://identifiers.org/biomodels.db/MODEL1310110057#_430f51eb_e0df_48aa_9d93_0393d52a2cec
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: ACOT8
type: Species
is encoded by: hsa:10005
is: O14734

metaR r0595
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 2.8.1.2 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:851908 NOTES:
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: false
fast: false
is described by: ECO:0000000
name: 3-Mercaptopyruvate:cyanide sulfurtransferase Cysteine metabolism EC:2.8.1.2
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_296f90bf_c2b1_41c0_be88_46190ddf8d12
constant: false
is: SBO:0000252
boundary condition: true
name: _BE966236_1_c
has only substance units: false
type: Species
is encoded by: hsa:BE966236
initial concentration: NaN
initial amount: NaN

metaM btcoa x
notes: FORMULA: C25H38N7O17P3S CHARGE: -4
is: C00136
has only substance units: false
name: Butanoyl-CoA
is: HMDB01088
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_b581d0a9_ebe8_4e86_b6da_155b3a99d051
initial concentration: NaN
boundary condition: true
is: Q86XP1
is: SBO:0000252
is encoded by: hsa:160851
constant: false
type: Species
name: DGKH
initial amount: NaN
has only substance units: false

metaR RE1533M
kinetic law: MODEL1310110057#
name: RE1533
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
fast: false
modifier: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110057#

metaR URATEt
kinetic law: MODEL1310110057#
reversible: false
fast: false
reactant: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: urate export from cytosol
type: Reaction
product: MODEL1310110057#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110057#_f87cafac_3364_4211_b58d_082a1048bf66
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is: P55084
type: Species
is encoded by: hsa:3032
initial concentration: NaN
initial amount: NaN
name: HADHB

http://identifiers.org/biomodels.db/MODEL1310110057#_dbdf9f3b_e581_4c47_80ed_421e2c431304
type: Species
initial concentration: NaN
initial amount: NaN
name: ACADS
is: P16219
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:35
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_deb2d322_5eeb_451b_bf47_b3bfe679ae92
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has part: P48201
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:518
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_e1761da1_96a1_454c_81c6_1491449fbee7
constant: false
is encoded by: hsa:686
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: BTD
is: P43251

metaR r0615
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.168
fast: false
type: Reaction
reactant: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
modifier: MODEL1310110057#
reversible: true
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2

http://identifiers.org/biomodels.db/MODEL1310110057#_53a8f5d5_9063_4e0e_a587_bd07f0a04c78
has only substance units: false
initial amount: NaN
is encoded by: hsa:2746
constant: false
is: E9KL48
boundary condition: true
is: SBO:0000252
name: GLUD1
initial concentration: NaN
type: Species

metaM galgalgalthcrm hs c
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:12936
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110057#_5917e2cb_66b7_4776_a213_73a215f4eb89
type: Species
constant: false
is: O43677
name: NDUFC1
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:4717
is: SBO:0000252

metaR r0596
type: Reaction
modifier: MODEL1310110057#
product: MODEL1310110057#
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
is described by: ECO:0000000
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
fast: false

metaM 5mta c
is: HMDB01173
boundary condition: false
is: SBO:0000247
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
is: CHEBI:17509
constant: false
has only substance units: false
is: C00170
type: Species
initial concentration: 1.0
initial amount: NaN
name: 5-Methylthioadenosine

metaR C3STDH1Pr
is described by: ECO:0000134
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110057#
name: C-3 sterol dehydrogenase (4-methylzymosterol)
is version of: http://identifiers.org/ec-code/1.1.1.170
modifier: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
fast: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ

metaR C141OHc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_7bf731f6_1573_4a05_9d56_296b91395b86
is encoded by: hsa:270
initial amount: NaN
is: P23109
type: Species
name: AMPD1
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_e730fa82_2dc4_4ac6_ad51_73d3b7ff147a
has only substance units: false
boundary condition: true
is: P48651
name: PTDSS1
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:9791

http://identifiers.org/biomodels.db/MODEL1310110057#_9417621f_5602_4b8c_a976_a2b107311679
is: SBO:0000252
initial concentration: NaN
name: NT5E
boundary condition: true
is: P21589
initial amount: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:4907

metaM sprm e
name: spermine(4+)
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
boundary condition: false
initial amount: NaN
is: CHEBI:45725
is: SBO:0000247
has only substance units: false
is: HMDB01256

metaM ipdp x
initial amount: NaN
is: SBO:0000247
is: CHEBI:128769
is: HMDB01347
has only substance units: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
constant: false
boundary condition: false
name: isopentenyl diphosphate(3-)
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110057#_b64f30a7_5b28_4624_8a2a_939920e98815
is: C9JFZ1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8867
type: Species
boundary condition: true
constant: false
initial amount: NaN
name: SYNJ1
has only substance units: false

metaR SPH1Pte
fast: false
reversible: true
name: sph1p transport
product: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
type: Reaction
is: SBO:0000185
reactant: MODEL1310110057#
is described by: ECO:0000000

metaM tdcoa x
is: C02593
initial concentration: 1.0
is: CHEBI:57385
boundary condition: false
is: HMDB01521
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
has only substance units: false
name: Tetradecanoyl-CoA (n-C14:0CoA)
type: Species
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_0e7ea90a_adcc_4e12_939a_a92084678e51
has only substance units: false
name: ST3GAL3
constant: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:6487
is: SBO:0000252
is: Q5T4Y1

metaR DDECE1CRNe
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of dodecenoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_0ea75a55_0f40_48c3_a1bf_52ef129c3948
constant: false
name: CCBL1
is: Q16773
type: Species
is encoded by: hsa:883
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM 42A3HP24DB c
type: Species
is: C05645
is: HMDB04083
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
constant: false
initial amount: NaN
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
has only substance units: false
is: http://identifiers.org/pubchem.compound/7956

metaM dpcoa e
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:57328
is: SBO:0000247
is: HMDB01373
boundary condition: false
initial amount: NaN
is: C00882
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
name: Dephospho-CoA

http://identifiers.org/biomodels.db/MODEL1310110057#_ce4e720a_9c12_4786_9f6b_099616fbf0cb
constant: false
is encoded by: hsa:10195
has only substance units: false
is: SBO:0000252
name: ALG3
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species

metaM ksi deg9 l
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
is: CHEBI:12936
is: HMDB00143
constant: false
initial amount: NaN
name: keratan sulfate I, degradation product 9
type: Species

metaR ABTD
fast: false
reactant: MODEL1310110057#
name: L-arabinitol 4-dehydrogenase
is described by: ECO:0000000
reversible: true
is: SBO:0000176
product: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaR 4MOPte
reversible: true
product: MODEL1310110057#
name: Transport of 4-methyl-2-oxopentanoate
type: Reaction
reactant: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110057#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_6eeb9167_9a7c_4ccf_95db_5136b9bddc25
is: SBO:0000252
is encoded by: hsa:1036
initial amount: NaN
constant: false
is: Q16878
initial concentration: NaN
has only substance units: false
name: CDO1
type: Species
boundary condition: true

metaM galgalgalthcrm hs e
is: SBO:0000247
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
type: Species
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
initial concentration: 1.0
is: C00124
initial amount: NaN
has only substance units: false
is: HMDB00143
is: CHEBI:0
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_62bbdeef_8f04_4fac_b4bc_5da9cf246c80
is: Q16774
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:2987
initial concentration: NaN
name: GUK1

http://identifiers.org/biomodels.db/MODEL1310110057#_760640cc_b74f_45e0_93c1_529749918135
type: Species
is: Q6IA69
initial concentration: NaN
is encoded by: hsa:55191
initial amount: NaN
boundary condition: true
name: NADSYN1
constant: false
has only substance units: false
is: SBO:0000252

metaR B3GALT3g
is: SBO:0000176
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
name: Beta-1,3-galactosyltransferase 3
reversible: false
modifier: MODEL1310110057#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.79
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000269

metaR G14T15g
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110057#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
product: MODEL1310110057#
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110057#

metaR RE2998M
is described by: ECO:0000000
modifier: MODEL1310110057#
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
reactant: MODEL1310110057#
name: RE2998
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110057#
fast: false

metaM arachcrn m
is: SBO:0000247
has only substance units: false
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
constant: false
name: arachidyl carnitine
boundary condition: false
initial concentration: 1.0
is: HMDB06460
type: Species
initial amount: NaN

metaR HPDCACRNt
name: heptadecanoate transport into the mitochondria
fast: false
reactant: MODEL1310110057#
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
type: Reaction
reversible: false
product: MODEL1310110057#
is described by: ECO:0000269

metaM hco3 c
constant: false
is: C00288
is: SBO:0000247
is: CHEBI:17544
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
name: Bicarbonate
is: HMDB00595
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
has only substance units: false

metaM acac e
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:13705
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: HMDB00060
name: acetoacetate

metaM coucoa m
initial amount: NaN
is: CHEBI:57355
is: C00223
type: Species
initial concentration: 1.0
notes: FORMULA: C30H38N7O18P3S1 CHARGE: -4 INCHI: InChI=1S/C30H42N7O18P3S/c1-30(2,25(42)28(43)33-10-9-20(39)32-11-12-59-21(40)8-5-17-3-6-18(38)7-4-17)14-52-58(49,50)55-57(47,48)51-13-19-24(54-56(44,45)46)23(41)29(53-19)37-16-36-22-26(31)34-15-35-27(22)37/h3-8,15-16,19,23-25,29,38,41-42H,9-14H2,1-2H3,(H,32,39)(H,33,43)(H,47,48)(H,49,50)(H2,31,34,35)(H2,44,45,46)/p-4/t19-,23-,24-,25+,29-/m1/s1
name: 4-coumaroyl-CoA(4-)
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false

metaR PYDXNK
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.35
fast: false
name: pyridoxine kinase
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110057#
product: MODEL1310110057#

metaR MANtg
type: Reaction
product: MODEL1310110057#
reversible: false
fast: false
is: SBO:0000185
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: mannose efflux from Golgi apparatus
is described by: ECO:0000000

metaR EX 4mptnl LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-methylpentanal Exchange
type: Reaction

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaR GARFT
fast: false
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.1.2.2
reactant: MODEL1310110057#
is described by: ECO:0000269
modifier: MODEL1310110057#
name: phosphoribosylglycinamide formyltransferase
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
kinetic law: MODEL1310110057#
type: Reaction
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_b25f8abf_89f6_4e2d_9264_924251e26dac
boundary condition: true
is encoded by: hsa:3030
name: HADHA
has only substance units: false
type: Species
is: SBO:0000252
is: E9KL44
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_cb464e39_2b45_49c8_bf20_018c06f613fb
has only substance units: false
name: GPX4
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: P36969
is: SBO:0000252
is encoded by: hsa:2879
boundary condition: true

metaR r0723
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
kinetic law: MODEL1310110057#
is described by: ECO:0000000
reactant: MODEL1310110057#
reversible: false
modifier: MODEL1310110057#
type: Reaction
is: SBO:0000176
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.3.1.41
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaM prostgi2 r
is: CHEBI:57403
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB01335
has only substance units: false
name: prostaglandin I2(1-)
initial concentration: 1.0
initial amount: NaN
constant: false

metaR ACACT1rm
fast: false
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110057#
is: SBO:0000176
product: MODEL1310110057#
name: acetyl-CoA C-acetyltransferase, mitochondrial
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110057#

metaR C141OHe
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:1-OH
type: Reaction

metaM crn c
name: L-Carnitine
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: HMDB00062
constant: false
is: CHEBI:16347
initial amount: NaN
is: C00318

http://identifiers.org/biomodels.db/MODEL1310110057#_8769e72f_19a1_463a_8ab1_3c7a1e36b716
name: NDUFA11
is encoded by: hsa:126328
type: Species
initial amount: NaN
constant: false
is: C9JT23
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM pyr c
has only substance units: false
is: http://identifiers.org/pubchem.compound/3324
initial amount: NaN
constant: false
is: HMDB00243
is: C00022
boundary condition: false
type: Species
name: pyruvate
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1
is: CHEBI:15361
initial concentration: 1.0

metaR r0033
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
reactant: MODEL1310110057#
product: MODEL1310110057#
modifier: MODEL1310110057#
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24

metaR GUACYC
reactant: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2977.1 and 2983.1) or (4882.2) or (2982.1 and 2974.1) or (2986.1) or (4882.1) or (2984.1) or (4881.1) or (2977.1 and 2974.1) or (3000.1) or (2982.1 and 2983.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.2 Confidence Level: 4 AUTHORS: PMID:10449911,PMID:10777682,PMID:11565546,PMID:11851379,PMID:1352257,PMID:14748740,PMID:15371450,PMID:7601467,PMID:7761400,PMID:7777544,PMID:7954658,PMID:8838319,PMID:9097965,PMID:9742212 NOTES:IT
reversible: false
type: Reaction
modifier: MODEL1310110057#
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/4.6.1.2
kinetic law: MODEL1310110057#
name: guanylate cyclase
fast: false
is described by: ECO:0000269

metaR THRGLYexR
fast: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000304
reactant: MODEL1310110057#
name: L-threonine/glycine reversible exchange
modifier: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_36d51e82_05aa_4a17_aa06_172131d10bfd
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:10786
initial concentration: NaN
type: Species
name: SLC17A3
initial amount: NaN
is: O00476
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_b79980eb_8cc8_45ff_b2dd_7f80784a44ee
has only substance units: false
initial amount: NaN
is: P05091
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:217
name: ALDH2
is: SBO:0000252
constant: false

metaR DHPM2
kinetic law: MODEL1310110057#
is described by: ECO:0000000
fast: false
product: MODEL1310110057#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 2 AUTHORS: NOTES:Also acts on dihydrothymine and hydantoin. Found not specific evidence in PubMed, but Dihydropyrimidinase is supposed to be in cytosol and catalyze this reaction. Old information
type: Reaction
is: SBO:0000176
reactant: MODEL1310110057#
name: dihydropyrimidinase (dihydrothymine)

metaR r0724
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.1.33
kinetic law: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
product: MODEL1310110057#
is: SBO:0000176
modifier: MODEL1310110057#

metaM s2l2n2m2m l
name: de-Fuc form of PA6 (w/o peptide linkage)
type: Species
constant: false
initial amount: NaN
is: CHEBI:50570
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C84H136N6O62 CHARGE: -2
is: SBO:0000247
boundary condition: false
is: HMDB06529

metaM 2hb c
boundary condition: false
is: SBO:0000247
is: HMDB00008
name: 2-Hydroxybutyrate
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
initial concentration: 1.0
constant: false
is: CHEBI:1148
type: Species
has only substance units: false
initial amount: NaN

metaM thcholstoic m
is: SBO:0000247
constant: false
is: HMDB03873
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
boundary condition: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
type: Species
is: CHEBI:18402
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_348e634b_64e3_492f_b718_02ff2be18d71
boundary condition: true
name: PRDX1
type: Species
is: Q06830
has only substance units: false
is encoded by: hsa:5052
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN

metaM f26bp c
is: CHEBI:58579
is: HMDB01047
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
name: beta-D-fructofuranose 2,6-bisphosphate(4-)
boundary condition: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-2-6(18-20(13,14)15)5(9)4(8)3(17-6)1-16-19(10,11)12/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4-,5+,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00484 EHMN_ABBREVIATION: C00665
initial amount: NaN

metaM hco3 e
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: C00288
is: CHEBI:17544
boundary condition: false
type: Species
is: HMDB00595
initial concentration: 1.0
name: Bicarbonate
constant: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288

metaM tag hs c
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:17855
initial concentration: 1.0
is: SBO:0000247
name: triglyceride
has only substance units: false
type: Species

metaM acac c
is: HMDB00060
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
name: acetoacetate
is: CHEBI:13705

metaR r0488
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
reversible: true
product: MODEL1310110057#
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
is described by: ECO:0000000
reactant: MODEL1310110057#
is: SBO:0000176
kinetic law: MODEL1310110057#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_e2bc76a2_86e8_47b3_9967_f7919bcd89a5
constant: false
is encoded by: hsa:9990
is: SBO:0000252
is: Q9UHW9
has only substance units: false
initial concentration: NaN
name: SLC12A6
initial amount: NaN
boundary condition: true
type: Species

metaM CE0849 m
constant: false
has only substance units: false
name: cis,cis-palmito-7,10-dienoyl-CoA
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
is: SBO:0000247
type: Species
is: CHEBI:57795

metaR INSTt4
reversible: true
is: SBO:0000185
product: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
fast: false
name: inositol transport via sodium symport
kinetic law: MODEL1310110057#
is described by: ECO:0000269
reactant: MODEL1310110057#
modifier: MODEL1310110057#

metaR DMNONCRNCPT2
kinetic law: MODEL1310110057#
name: DMNONCRNCPT2
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
reactant: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000000
reversible: true

metaM crn e
is: CHEBI:16347
initial amount: NaN
initial concentration: 1.0
is: C00318
is: HMDB00062
is: SBO:0000247
type: Species
name: L-Carnitine
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

metaM ksi pre30 g
type: Species
is: HMDB00175
constant: false
initial concentration: 1.0
is: C00130
is: CHEBI:58053
is: SBO:0000247
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 30
has only substance units: false
boundary condition: false

metaR DHPM1
is version of: http://identifiers.org/ec-code/3.5.2.2
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
reversible: false
product: MODEL1310110057#
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110057#
name: dihydropyrimidinase (5,6-dihydrouracil)

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaR ACt2m
fast: false
kinetic law: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
reactant: MODEL1310110057#
is described by: ECO:0000000
product: MODEL1310110057#
reversible: true
name: acetate mitochondrial transport via proton symport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_695279ca_5851_4fde_a8a8_aadc952da1e0
constant: false
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
name: PDE8B
initial amount: NaN
is encoded by: hsa:8622
is: O95263
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_f1bac4f3_1efb_4613_9f02_126dd71abf67
is: G3XA95
name: PPAP2A
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8611

http://identifiers.org/biomodels.db/MODEL1310110057#_fe76849c_5985_486c_acfb_930156737f19
type: Species
is: A7E2E0
constant: false
has only substance units: false
is: SBO:0000252
name: PIK3CD
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:5293

http://identifiers.org/biomodels.db/MODEL1310110057#_0ebfb537_d240_4495_921c_ef4c002f95a3
type: Species
is encoded by: hsa:PRO1933
initial concentration: NaN
boundary condition: true
name: _PRO1933_1_m
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252

metaM pyr e
initial amount: NaN
constant: false
is: HMDB00243
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:15361
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
name: pyruvate
initial concentration: 1.0

metaR FAOXC10C8m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_8ab5b32d_5f22_43b8_b486_77ba6367e4a7
initial concentration: NaN
is: SBO:0000252
name: ALG5
type: Species
constant: false
is: Q9Y673
is encoded by: hsa:29880
boundary condition: true
has only substance units: false
initial amount: NaN

metaR GGH 6DHFe
is: SBO:0000176
fast: false
modifier: MODEL1310110057#
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
name: Gamma-glutamyl hydrolase (6DHF), extracellular
reversible: false
reactant: MODEL1310110057#

metaR SERGLYexR
is described by: ECO:0000304
is: SBO:0000185
fast: false
reactant: MODEL1310110057#
reversible: true
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
name: L-Serine/Glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110057#

metaR DOLMANP Lter
type: Reaction
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: dolichol-phosphate mannose flippase (liver)
fast: false
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000185

metaM duri e
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: C00526
initial concentration: 1.0
initial amount: NaN
is: HMDB00012
name: Deoxyuridine
type: Species
is: CHEBI:16450

metaM 3hexdtetcoa m
initial amount: NaN
is: HMDB02288
boundary condition: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
name: 3,7,10,13-hexadecatetraenoylcoa
has only substance units: false
initial concentration: 1.0
constant: false

metaR r0722
is: SBO:0000176
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/4.2.3.12
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
fast: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110057#_e5d8eba5_bf04_4d39_95b6_a45b2b1a6841
type: Species
boundary condition: true
name: PDE9A
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5152
has only substance units: false
constant: false
is: SBO:0000252

metaM 2hb e
is: HMDB00008
has only substance units: false
boundary condition: false
name: 2-Hydroxybutyrate
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
initial concentration: 1.0
is: CHEBI:1148
initial amount: NaN
type: Species
is: SBO:0000247

metaR RE0688E
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
type: Reaction
name: RE0688
product: MODEL1310110057#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_35618448_ec1e_45dc_adf7_3c10c5ae87dc
name: DGKZ
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: G3V0F6
is encoded by: hsa:8525
type: Species
constant: false
initial concentration: NaN

metaM tag hs e
initial amount: NaN
name: triglyceride
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
has only substance units: false
constant: false
is: CHEBI:17855

metaR FAOXC2242046m
fast: false
modifier: MODEL1310110057#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110057#
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
type: Reaction
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110057#_73d316e3_620f_4cf3_ba2c_40c6ab7d16e9
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:112
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: ADCY6

http://identifiers.org/biomodels.db/MODEL1310110057#_1be31b72_6987_4c12_a20a_69b4bbffd240
name: ST3GAL3
initial concentration: NaN
is encoded by: hsa:6487
constant: false
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_dc986085_70da_474b_a772_2122c67ad819
constant: false
has only substance units: false
is encoded by: hsa:25769
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: SLC24A2
type: Species
is: Q9UI40
boundary condition: true

metaR FAOXC181C181OHm
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C18:1OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_0fbdf1a6_1a66_45a0_b30e_464f321331cd
is encoded by: hsa:65985
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: AACS
is: Q86V21
initial concentration: NaN
has only substance units: false

metaR DOPASULT
is version of: http://identifiers.org/ec-code/2.8.2.1
reversible: false
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
name: Dopamine Sulfotransferase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)
reactant: MODEL1310110057#
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110057#

metaR PI45PLC
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110057#
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.1.4.11
is described by: ECO:0000000
kinetic law: MODEL1310110057#
reversible: false

metaR CRNrtx
reversible: true
fast: false
is described by: ECO:0000134
reactant: MODEL1310110057#
is: SBO:0000185
type: Reaction
name: reversible transport of L-Carnitine in peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
product: MODEL1310110057#
kinetic law: MODEL1310110057#

metaM Rtotal2 c
initial concentration: 1.0
is: HMDB01564
is: CHEBI:57876
name: R total 2 position
notes: FORMULA: CO2FULLR2 CHARGE: -1
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false

metaM arach c
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
is: CHEBI:32360
initial concentration: 1.0
name: arachidate
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: HMDB02212

metaR RE2759X
is version of: http://identifiers.org/ec-code/5.1.99.4
reversible: true
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (23600.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:11060344,PMID:11060359 NOTES:
fast: false
product: MODEL1310110057#
is: SBO:0000176
modifier: MODEL1310110057#
type: Reaction
is described by: ECO:0000000
name: RE2759
reactant: MODEL1310110057#

metaM hdd2coa x
initial amount: NaN
name: (E)-hexadec-2-enoyl-CoA(4-)
is: CHEBI:61526
is: SBO:0000247
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB03945
constant: false

metaM duri m
initial amount: NaN
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
type: Species
is: CHEBI:16450
initial concentration: 1.0
name: 2'-deoxyuridine
is: HMDB00012

metaR r0932
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110057#
name: Transport reaction
type: Reaction
reversible: true
reactant: MODEL1310110057#
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110057#

metaR B3GNT31g
type: Reaction
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
reversible: false
is: SBO:0000176
modifier: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000269
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus

metaM c81coa c
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: HMDB03949
name: octenoylcoa
is: C05276
is: SBO:0000247
boundary condition: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110057#_af9ada9b_1308_429e_975f_576ec5346579
name: EGFL8
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:80864
boundary condition: true
type: Species
constant: false
is: Q99944

metaR EX CE5868 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acetyl-seryl-aspartate exchange
type: Reaction

metaR r0728
product: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110057#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110057#
fast: false
reversible: true
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

metaR GGH 5DHFe
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
type: Reaction
product: MODEL1310110057#
modifier: MODEL1310110057#
name: Gamma-glutamyl hydrolase (5DHF), extracellular
is: SBO:0000176
kinetic law: MODEL1310110057#
is described by: ECO:0000000
reversible: false

metaM tdcoa m
has only substance units: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
initial amount: NaN
is: HMDB01521
is: CHEBI:57385
name: Tetradecanoyl-CoA (n-C14:0CoA)
initial concentration: 1.0
is: SBO:0000247
is: C02593
boundary condition: false
type: Species
constant: false

metaR 34DHXMANDACOX NADP
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
is described by: ECO:0000269
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
product: MODEL1310110057#
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110057#

metaR EX lpchol hs LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lysophosphatidylcholine
type: Reaction

metaR r0931
is described by: ECO:0000000
kinetic law: MODEL1310110057#
name: Transport reaction
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110057#
reversible: false
type: Reaction

metaR DOLPMT1 Ler
is: SBO:0000176
fast: false
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.258
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110057#
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110057#_metaM_galacglcgal14acglcgalgluside_hs_g
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0
is: SBO:0000247
is: CHEBI:26174
type: Species
initial amount: NaN
name: i-antigen
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false

metaM arach e
is: CHEBI:32360
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: arachidate
type: Species
constant: false
has only substance units: false
is: HMDB02212
boundary condition: false

metaM Rtotal2 e
boundary condition: false
is: HMDB00244
initial concentration: 1.0
constant: false
name: R total 2 position
notes: FORMULA: CO2FULLR2 CHARGE: -1
type: Species
is: CHEBI:3554
initial amount: NaN
is: SBO:0000247
is: C00255
has only substance units: false

metaM thcholstoic r
is: SBO:0000247
constant: false
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: CHEBI:18402
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
has only substance units: false
type: Species
is: HMDB03873
boundary condition: false
initial amount: NaN

metaR RE0452M
reversible: true
fast: false
is described by: ECO:0000000
name: RE0452
reactant: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110057#

metaR PROSTGI2tr
reactant: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000185
kinetic law: MODEL1310110057#
name: Prostaglandin I2 transport (ER)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is described by: ECO:0000269
reversible: true
type: Reaction
fast: false

metaR DOLPMT4 Ler
kinetic law: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
reversible: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
type: Reaction
reactant: MODEL1310110057#
fast: false
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_ac496ad4_16b5_4d1b_9414_bf4d76137917
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: P07954
name: FH
is: SBO:0000252
is encoded by: hsa:2271
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_44c5410f_08bc_4c07_b9da_602affc61bbb
boundary condition: true
has only substance units: false
is encoded by: hsa:5287
name: PIK3C2B
type: Species
is: O00750
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR ACt2r
is described by: ECO:0000000
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
type: Reaction
fast: false
name: acetate reversible transport via proton symport
reactant: MODEL1310110057#
is: SBO:0000185

metaM 5HPET c
is: HMDB01193
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
name: 5(S)-HPETE(1-)
is: SBO:0000247
is: CHEBI:57450
boundary condition: false
initial amount: NaN

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_8533966f_f6ef_43a5_988a_17558c6fc7b0
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:H77542
type: Species
name: _H77542_1_c
boundary condition: true
initial amount: NaN
constant: false

metaR 10FTHFtm
fast: false
product: MODEL1310110057#
is: SBO:0000185
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
reactant: MODEL1310110057#
reversible: true
kinetic law: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110057#_66f9d64b_29dc_41d6_88e2_7983496d2695
is: O00330
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
name: PDHX
type: Species
is: SBO:0000252
is encoded by: hsa:8050

http://identifiers.org/biomodels.db/MODEL1310110057#_263bf124_6333_4cc0_84cf_1fd7bf3df48b
is encoded by: hsa:28976
type: Species
has only substance units: false
is: Q9H845
initial amount: NaN
initial concentration: NaN
name: ACAD9
is: SBO:0000252
constant: false
boundary condition: true

metaR r1418
kinetic law: MODEL1310110057#
reversible: true
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
product: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110057#
type: Reaction

metaR r1979
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
fast: false
product: MODEL1310110057#
modifier: MODEL1310110057#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110057#
reversible: false
reactant: MODEL1310110057#

metaM dpcoa m
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
name: 3'-dephospho-CoA(2-)
is: CHEBI:57328
constant: false
is: HMDB01373
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR r0726
modifier: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: true
reactant: MODEL1310110057#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.33
type: Reaction
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000176

metaR G14T2g
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reactant: MODEL1310110057#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110057#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90

http://identifiers.org/biomodels.db/MODEL1310110057#_eaa27dc5_3a50_483b_93a8_31806cafa3af
is encoded by: hsa:AL038231
name: _AL038231_1_c
initial amount: NaN
boundary condition: true
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaR r1977
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110057#
is described by: ECO:0000000
fast: false
product: MODEL1310110057#
reactant: MODEL1310110057#
modifier: MODEL1310110057#
reversible: false

metaM btcoa m
constant: false
name: Butanoyl-CoA
is: SBO:0000247
is: HMDB01088
type: Species
boundary condition: false
is: C00136
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57371
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136

metaM CE4872 c
has only substance units: false
constant: false
is: HMDB00127
is: CHEBI:15748
type: Species
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
is: SBO:0000247
initial amount: NaN
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
initial concentration: 1.0
boundary condition: false

metaR CO2t
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
kinetic law: MODEL1310110057#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: CO2 transporter via diffusion
product: MODEL1310110057#
reversible: true

metaM ha pre1 l
boundary condition: false
name: hyaluronan biosynthesis, precursor 1
initial amount: NaN
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16126
type: Species
constant: false

metaM tddedicoa m
boundary condition: false
constant: false
type: Species
initial amount: NaN
name: trans3,6dodecadienoylcoa
is: http://identifiers.org/pubchem.compound/5280771
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0

metaR MMMm
type: Reaction
product: MODEL1310110057#
is: SBO:0000176
reactant: MODEL1310110057#
is described by: ECO:0000269
modifier: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/5.4.99.2
name: methylmalonyl-CoA mutase
reversible: true
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
kinetic law: MODEL1310110057#

metaM h e
initial concentration: 1.0
boundary condition: false
is: C00080
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: "
constant: false
is: SBO:0000247
has only substance units: false
name: proton
is: http://identifiers.org/pubchem.compound/3380
type: Species
is: CHEBI:24636

http://identifiers.org/biomodels.db/MODEL1310110057#_b0a04764_984e_45c3_b2a3_bf94d11cb2d8
is: SBO:0000252
is encoded by: hsa:55229
initial amount: NaN
boundary condition: true
name: PANK4
type: Species
initial concentration: NaN
has only substance units: false
is: Q9NVE7
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_413c1d0b_dd44_4f69_b0a7_d954adb4f1d9
initial amount: NaN
is encoded by: hsa:7378
constant: false
type: Species
has only substance units: false
boundary condition: true
is: Q16831
is: SBO:0000252
initial concentration: NaN
name: UPP1

http://identifiers.org/biomodels.db/MODEL1310110057#_fe0915ea_0556_49b1_99f4_5a848bab1c99
initial concentration: NaN
initial amount: NaN
is: Q14442
has only substance units: false
boundary condition: true
name: PIGH
is: SBO:0000252
constant: false
is encoded by: hsa:5283
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_c418f5af_6ad3_42bf_9ed4_8cfdc61fbbfe
name: SGPP1
is: Q9BX95
initial amount: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:81537
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM lnlncgcrn m
is: HMDB06318
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: gamma-linolenyl carnitine
boundary condition: false
initial amount: NaN

metaR NAGLCAly
is described by: ECO:0000000
reactant: MODEL1310110057#
product: MODEL1310110057#
reversible: false
kinetic law: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
type: Reaction
is: SBO:0000176
name: N-acetylglucosaminidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110057#_3bc5f682_3b6b_4cfa_b13c_b64f91643ae7
boundary condition: true
name: LHPP
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:64077
is: Q9H008
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_46e0bac5_9d71_46ad_aea9_5b62f7510d63
is encoded by: hsa:3704
has only substance units: false
constant: false
name: ITPA
type: Species
is: Q9BY32
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR FAOXC16080m
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
type: Reaction
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_6555fe85_66d1_4ddc_8cc7_c54557975978
is encoded by: hsa:55753
initial concentration: NaN
name: OGDHL
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q9ULD0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_202cb669_2384_4d7e_b1f6_0cc229fcf84b
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
name: FTCD
is encoded by: hsa:10841
has only substance units: false
constant: false

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaR SADT
name: sulfate adenylyltransferase
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
reversible: false
product: MODEL1310110057#
fast: false
modifier: MODEL1310110057#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.25
type: Reaction
reactant: MODEL1310110057#
is described by: ECO:0000269

metaR PROt2r
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
modifier: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000304
is: SBO:0000185
kinetic law: MODEL1310110057#
name: L-proline reversible transport via proton symport
reactant: MODEL1310110057#
reversible: true
fast: false

metaR RE0453M
reversible: true
name: RE0453
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000000
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is: SBO:0000176
product: MODEL1310110057#

metaM adn e
boundary condition: false
is: HMDB00050
has only substance units: false
initial amount: NaN
name: Adenosine
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:16335
is: C00212
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
type: Species

metaR DECDPtm
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:ubiquinone precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110057#

metaM 2octdectecoa m
boundary condition: false
is: http://identifiers.org/pubchem.compound/5280355
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial amount: NaN
name: 2,6,9,12-octadecatetraenoylcoa
type: Species

metaR RE0583C
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
is: SBO:0000176
product: MODEL1310110057#
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
name: RE0583

http://identifiers.org/biomodels.db/MODEL1310110057#_3712cf3d_23d5_4226_bb2e_fcb9420f6d05
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:3635
is: Q92835
constant: false
is: SBO:0000252
type: Species
boundary condition: true
name: INPP5D

metaM etoh e
name: ethanol
boundary condition: false
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16236
is: HMDB00108
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_e45ad2b4_7249_4eb7_8629_fabda0d256ea
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:W87865
constant: false
type: Species
name: _W87865_1_c
is: SBO:0000252
boundary condition: true

metaM fald c
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:16842
is: SBO:0000247
name: formaldehyde
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
is: HMDB01426

metaR AATAi
reversible: false
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110057#
name: 2-aminoadipate transaminase, irreversible
notes: GENE_ASSOCIATION: (51166.1) or (51166.2) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 4 AUTHORS: PMID:12126930 NOTES:MM
is: SBO:0000176
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.6.1.7
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_65c4fba4_71dc_4f8d_a6a1_d2d25eb7ff40
is encoded by: hsa:5373
boundary condition: true
type: Species
is: O15305
name: PMM2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false

metaR RE1810M
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
reversible: true
product: MODEL1310110057#
fast: false
is described by: ECO:0000000
name: RE1810
reactant: MODEL1310110057#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_babb78f0_42cb_46c0_8878_25ee2e637ca4
constant: false
has only substance units: false
initial concentration: NaN
is: P16499
type: Species
is encoded by: hsa:5145
initial amount: NaN
boundary condition: true
name: PDE6A
is: SBO:0000252

metaM c12dccoa x
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
boundary condition: false
constant: false
name: dodecanedioylcoa
type: Species
is: HMDB03712

metaR r0027
modifier: MODEL1310110057#
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.39
product: MODEL1310110057#
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
type: Reaction

metaM retinal c
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: retinal
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
is: CHEBI:15035
type: Species
is: HMDB01358
initial concentration: 1.0
has only substance units: false

metaR VALTA
is described by: ECO:0000269
name: valine transaminase
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
type: Reaction
reversible: true
modifier: MODEL1310110057#
is: SBO:0000176
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.6.1.42
fast: false
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_c365ff15_af5a_48fe_a2ca_ce5dbb020652
is: SBO:0000252
has only substance units: false
is: H0UI06
constant: false
initial amount: NaN
type: Species
name: COX7A2
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1347

metaM h c
notes: FORMULA: H CHARGE: 1 INCHI: "
boundary condition: false
has only substance units: false
name: proton
is: C00080
initial amount: NaN
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3380
type: Species
is: CHEBI:24636
initial concentration: 1.0

metaM nadp r
is: CHEBI:58349
is: C00006
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00217
constant: false
name: Nicotinamide adenine dinucleotide phosphate
initial concentration: 1.0
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006

metaM ctdecdcoa m
is: C08277
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species
name: cis2trans4decadienoylcoa
is: HMDB00792
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM pyr m
constant: false
name: pyruvate
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
type: Species
is: HMDB00243
initial concentration: 1.0
is: SBO:0000247
is: C00022
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3324
boundary condition: false
is: CHEBI:15361
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_9636dba2_52a8_4231_97ae_b190b104b840
is: SBO:0000252
constant: false
name: CYBRD1
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is: B4DWD7
is encoded by: hsa:79901

metaM hexdiac c
is: HMDB00672
notes: FORMULA: C16H28O4 CHARGE: -2
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
constant: false
name: hexadecanediocacid
is: C08260
initial amount: NaN

metaR UDPDOLPT L
reversible: false
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
reactant: MODEL1310110057#
fast: false
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110057#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.117
product: MODEL1310110057#

metaR FMNALKPle
reactant: MODEL1310110057#
name: FMNALKPle
is described by: ECO:0000134
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000176
product: MODEL1310110057#

metaM hco3 m
initial amount: NaN
is: SBO:0000247
type: Species
is: C00288
name: Bicarbonate
is: HMDB00595
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:17544
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_01699ee8_be90_4017_bd01_2475cc6d40f9
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:5151
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
name: PDE8A

metaR PRGNLONESULT
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.8.2.2
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.8.2.14
fast: false
is: SBO:0000176
name: steroid sulfotransferase
modifier: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (6822.1) or (6820.2) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:12145317,PMID:9799594 NOTES:NJ
reversible: false

metaM etoh c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00108
has only substance units: false
type: Species
constant: false
is: CHEBI:16236
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
name: ethanol

metaR RE3001M
is: SBO:0000176
reversible: true
type: Reaction
name: RE3001
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.34
is described by: ECO:0000000
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
reactant: MODEL1310110057#
fast: false

metaM adn c
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: SBO:0000247
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: C00212
initial concentration: 1.0
has only substance units: false
is: CHEBI:16335
is: HMDB00050
name: Adenosine

metaR ACGALtlg
is: SBO:0000185
reactant: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism - may be vesicular NJ
product: MODEL1310110057#
name: N-acetyl-galactosamine intracellular transport
reversible: true

metaR HIBDm
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
kinetic law: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
is described by: ECO:0000269
reversible: true
is: SBO:0000176
reactant: MODEL1310110057#
product: MODEL1310110057#
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.1.1.31
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_c1e55056_9d38_45b8_a70a_1116c7eb77f3
is: P34059
name: GALNS
initial concentration: NaN
is encoded by: hsa:2588
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
has only substance units: false

metaR B3GNT313g
is described by: ECO:0000254
fast: false
reversible: false
is: SBO:0000176
type: Reaction
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reactant: MODEL1310110057#
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
kinetic law: MODEL1310110057#
product: MODEL1310110057#

metaR r0720
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
reversible: false
is: SBO:0000176
fast: false
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110057#_28ddca88_f2dd_4ae5_8504_d2c2124b0e87
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species
is: Q6UWQ5
initial concentration: NaN
boundary condition: true
name: LYZL1
is encoded by: hsa:84569

http://identifiers.org/biomodels.db/MODEL1310110057#_4274f4e6_f7dd_4baa_8bc0_8bab04f09998
constant: false
is: SBO:0000297
has part: P33402
is encoded by: hsa:2983
is encoded by: hsa:2977
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: GUCY1A2:GUCY1B3
has part: Q02153

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_37851716_55ea_4a19_bbb1_0b18a3b9d6bd
boundary condition: true
name: _AI684467_1_m
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI684467
type: Species
has only substance units: false

metaM lgnc e
boundary condition: false
name: lignocerate
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
is: HMDB02003
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:31014
constant: false
has only substance units: false
is: SBO:0000247

metaM duri c
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial concentration: 1.0
is: CHEBI:16450
initial amount: NaN
has only substance units: false
is: C00526
name: Deoxyuridine
is: HMDB00012
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110057#_200f6ff3_c62e_4472_9dd5_d65e9c57d4ab
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: GCDH
initial concentration: NaN
is encoded by: hsa:2639
is: Q92947
is: SBO:0000252

metaM 4aphdob c
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: HMDB00978
is: CHEBI:58147
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR PGISr
kinetic law: MODEL1310110057#
reversible: true
is version of: http://identifiers.org/ec-code/5.3.99.4
modifier: MODEL1310110057#
product: MODEL1310110057#
name: Prostaglandin I2 synthase
is: SBO:0000176
is described by: ECO:0000134
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ
reactant: MODEL1310110057#

metaM 5tedtricoa m
constant: false
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
name: 5,8,11-tetradecatrienoylcoa
initial concentration: 1.0
is: HMDB02288
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_ddf37eec_abd4_4ed3_a163_590bac2c2dde
initial amount: NaN
name: ACADM
is: P11310
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:34
boundary condition: true
constant: false
type: Species
has only substance units: false

metaM 2dpmhobq m
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C58H88O4 CHARGE: 0 INCHI: InChI=1S/C58H88O4/c1-43(2)23-14-24-44(3)25-15-26-45(4)27-16-28-46(5)29-17-30-47(6)31-18-32-48(7)33-19-34-49(8)35-20-36-50(9)37-21-38-51(10)39-22-40-52(11)41-42-54-53(12)55(59)57(61)58(62-13)56(54)60/h23,25,27,29,31,33,35,37,39,41,61H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b44-25+,45-27+,46-29+,47-31+,48-33+,49-35+,50-37+,51-39+,52-41+
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:50771
is: HMDB06484
name: 2-decaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone

metaR r0494
reactant: MODEL1310110057#
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
product: MODEL1310110057#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110057#

metaM HC01223 m
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
is: CHEBI:57340
type: Species
constant: false
is: SBO:0000247
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM dcsptn1 e
is: HMDB13123
initial amount: NaN
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoic acid
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/5282848
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
constant: false

metaR FAOXC1811603m
name: Beta oxidation fatty acid
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
modifier: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
is: SBO:0000176

metaR AIRCr
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.2.6
reactant: MODEL1310110057#
product: MODEL1310110057#
name: phosphoribosylaminoimidazole carboxylase
fast: false
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000269
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110057#_334780b1_864b_42b2_a268_5e9324b3db04
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
name: DPM2
has only substance units: false
initial amount: NaN
boundary condition: true
is: O94777
is encoded by: hsa:8818

metaR HIVCACBP
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyisovalerylcoa from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_1a2511e5_419b_46fb_9160_0a24f1ecc33c
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
name: SLC26A6
initial amount: NaN
is encoded by: hsa:65010
is: Q9Y3Y1
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_b3ec4c3a_6ef8_46d7_aaaa_a4f4ed91c9b6
is encoded by: hsa:AI824319
constant: false
initial concentration: NaN
name: _AI824319_1_r
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false

metaM fum m
is: HMDB00134
boundary condition: false
initial amount: NaN
is: CHEBI:29806
constant: false
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
name: Fumarate
initial concentration: 1.0
is: C00122

metaR FAS100COA
fast: false
name: fatty acyl-CoA synthase (n-C10:0CoA)
reactant: MODEL1310110057#
product: MODEL1310110057#
reversible: false
kinetic law: MODEL1310110057#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000269
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_ff605941_2ec9_45bc_813a_81a5ee87fb10
is encoded by: hsa:9487
constant: false
initial concentration: NaN
boundary condition: true
name: PIGL
type: Species
is: Q9Y2B2
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_002ce4d4_2aa1_4877_8acb_58ec73b3190b
is encoded by: hsa:6508
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: SLC4A3
has only substance units: false
type: Species
constant: false

metaR r0497
is: SBO:0000176
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
type: Reaction
reactant: MODEL1310110057#
reversible: true
is described by: ECO:0000000
product: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/1.2.4.2
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_a342ce90_98eb_46b6_8e0b_ada2342b1551
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:55907
is: Q8NFW8
name: CMAS
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_f851abb3_f9a0_4069_a9bf_0548b1a67a4f
is encoded by: hsa:6487
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: B4DX62
initial concentration: NaN
boundary condition: true
name: ST3GAL3

metaR GALNTg
is: SBO:0000176
type: Reaction
name: GalNAc transferase, Golgi apparatus
reversible: false
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
modifier: MODEL1310110057#
product: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.41

metaM hdd2coa c
boundary condition: false
constant: false
type: Species
is: C05272
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: HMDB03945
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: trans-Hexadec-2-enoyl-CoA
is: CHEBI:61526

metaM thp2c c
name: 1-piperideine-6-carboxylate
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:16987
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
is: HMDB12130
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM nadp x
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00217
constant: false
initial amount: NaN
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: SBO:0000247
is: CHEBI:58349
name: Nicotinamide adenine dinucleotide phosphate
is: C00006
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_11d44527_6ec1_4401_903f_cfe1033b8649
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
name: PDE1A
is: SBO:0000252
is: Q9Y633
type: Species
initial concentration: NaN
is encoded by: hsa:5136

metaM dcsptn1 c
name: docosa-4,7,10,13,16-pentaenoic acid
is: HMDB13123
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
is: http://identifiers.org/pubchem.compound/5282848

metaM ha pre1 e
constant: false
is: SBO:0000247
has only substance units: false
name: hyaluronan biosynthesis, precursor 1
is: CHEBI:16126
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
initial amount: NaN

metaM prostge2 e
boundary condition: false
initial concentration: 1.0
is: HMDB01220
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
constant: false
is: CHEBI:606564
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
name: prostaglandin E2(1-)

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaR CYTK10n
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
name: cytidylate kinase (CMP,dGTP),nuclear
fast: false
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_91963df4_b21d_41a9_96d3_854a40af3dc4
type: Species
is encoded by: hsa:3036
name: HAS1
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: Q8IYH3
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_bb20e6c5_1eba_4d1b_900f_5e40727e6d3a
is: SBO:0000252
constant: false
is encoded by: hsa:514
initial concentration: NaN
name: ATP5E
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false

metaM h m
has only substance units: false
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
constant: false
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: proton
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
is: C00080

metaR S23T2g
kinetic law: MODEL1310110057#
fast: false
product: MODEL1310110057#
modifier: MODEL1310110057#
reactant: MODEL1310110057#
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.4
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176

metaR r0611
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.2.3.1
fast: false
reversible: true
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251 NOTES:
is described by: ECO:0000000
product: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
is: SBO:0000176
name: ITP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11

http://identifiers.org/biomodels.db/MODEL1310110057#_db44ccb8_e050_4e40_a9ac_1cd3cc9660f7
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q9NST1
initial amount: NaN
type: Species
is encoded by: hsa:80339
constant: false
name: PNPLA3
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_1f10d11e_284c_4444_bb92_c94d0b2945a5
type: Species
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:223
has only substance units: false
is: P49189
is: SBO:0000252
name: ALDH9A1
initial concentration: NaN

metaR r2506
product: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110057#
name: Utilized transport

metaM lnlnca l
name: alpha-linolenate
boundary condition: false
is: HMDB01388
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
type: Species
has only substance units: false
constant: false
is: CHEBI:32387
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_67c37620_5811_4345_abd1_ffddfcee0f36
boundary condition: true
is encoded by: hsa:400410
is: SBO:0000252
initial concentration: NaN
name: ST20
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: Q9HBF5

metaM ddsmsterol r
constant: false
is: SBO:0000247
name: 7-dehydrodesmosterol
is: CHEBI:27910
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
initial concentration: 1.0
type: Species
is: HMDB03896
boundary condition: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_0766e543_b141_4514_937a_9988bf091802
is: B7Z792
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:4720
initial amount: NaN
is: SBO:0000252
name: NDUFS2
has only substance units: false

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_d57046de_85c2_47ce_9502_a457af79f0db
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5634
name: PRPS2
is: P11908

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_d2e26cf3_2f6a_4bac_840a_4d14aae69de2
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: PLCH2
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: O75038
is encoded by: hsa:9651

metaR S6T15g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is described by: ECO:0000000
fast: false
reversible: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.8.2.17
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.21

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

metaM h n
type: Species
is: SBO:0000247
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:24636
constant: false
initial concentration: 1.0

metaM orot e
has only substance units: false
is: HMDB00226
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: SBO:0000247
initial concentration: 1.0
constant: false
name: orotate
type: Species
is: CHEBI:30839
initial amount: NaN
boundary condition: false

metaM 5HPET r
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:57450
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
boundary condition: false
is: HMDB01193
name: 5(S)-HPETE(1-)

http://identifiers.org/biomodels.db/MODEL1310110057#_7e2725e3_2cae_4429_8711_be533fc261e8
name: _AI222095_1_m
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:AI222095
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_b32089a6_f08e_47d5_a567_6a5bf489cb08
is encoded by: hsa:53354
constant: false
is: Q8TE04
initial concentration: NaN
name: PANK1
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR r0610
is: SBO:0000176
product: MODEL1310110057#
name: CTP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
kinetic law: MODEL1310110057#
reversible: true
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251,PMID:193556,PMID:2987258,PMID:6091737 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction

metaR DRBK
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.15 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
name: Deoxyribokinase
product: MODEL1310110057#
reactant: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
is described by: ECO:0000304
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.15
kinetic law: MODEL1310110057#

metaR RTOTALFATPc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

metaR EX leugly LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylglycine
type: Reaction

metaR LSTO1r
name: Lathosterol oxidase
product: MODEL1310110057#
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.21.6
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
reversible: false
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_897367eb_0c8b_4d05_ad8f_f342daaed7b1
is: P22392
is encoded by: hsa:4831
boundary condition: true
type: Species
name: NME2
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR ACONT
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000134
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.3
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3658.1) or (48.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:SMP. Biochemical
name: aconitase
product: MODEL1310110057#
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_f6abf4ae_6cce_4cb6_8e42_14afd6a26b0b
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is: Q4F7X0
name: ADCY8
is encoded by: hsa:114
type: Species
has only substance units: false

metaM ha e
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
constant: false
name: hyaluronan
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:16336

metaM prist x
initial amount: NaN
is: SBO:0000247
name: pristanic acid
boundary condition: false
type: Species
is: CHEBI:51340
constant: false
initial concentration: 1.0
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
is: HMDB00795
has only substance units: false

metaM prostge2 c
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB01220
initial amount: NaN
type: Species
name: prostaglandin E2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: CHEBI:606564
is: SBO:0000247
constant: false

metaR RE3628M
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
name: RE3628
product: MODEL1310110057#
type: Reaction
reversible: true
modifier: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/5.3.3.8
is described by: ECO:0000000
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110057#
is: SBO:0000176

metaM CE4872 m
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: HMDB00127
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
is: CHEBI:15748
boundary condition: false
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110057#_7662cbcb_2ab5_4936_9116_24b54655d272
is encoded by: hsa:4842
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
name: NOS1
is: B4DG68
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_7fa67edf_f58f_49fb_979b_798b52b3ac87
is: Q02338
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:622
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: BDH1

http://identifiers.org/biomodels.db/MODEL1310110057#_482f0256_04b7_4068_8df3_46da95e31503
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6487
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: ST3GAL3
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_691108db_049d_4773_9dbb_475a466025e0
is: SBO:0000252
name: ALDH3B1
initial amount: NaN
is: P43353
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:221
has only substance units: false
type: Species

metaR EX CE4723 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: neocasomorphin (1-5) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_0595aa34_ca73_4ddd_921f_479354d89b5d
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q9H3S5
boundary condition: true
is encoded by: hsa:93183
type: Species
name: PIGM
is: SBO:0000252
constant: false

metaM lnlncgcrn c
type: Species
boundary condition: false
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1
initial amount: NaN
name: gamma-linolenyl carnitine
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB06318

metaM 3hdececrn c
initial amount: NaN
has only substance units: false
name: 3-hydroxyhexadecenoylcarnitine
boundary condition: false
notes: FORMULA: C23H43NO5 CHARGE: 0
constant: false
initial concentration: 1.0
is: HMDB02014
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_951d59d8_986d_4594_aa6a_470521236480
has only substance units: false
initial amount: NaN
is encoded by: hsa:6550
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P48764
constant: false
type: Species
name: SLC9A3

http://identifiers.org/biomodels.db/MODEL1310110057#_957503ff_27b2_40a1_b835_b32a3b5a2aca
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
type: Species
initial amount: NaN
has part: Q6IB54
is encoded by: hsa:522
has only substance units: false
constant: false
is: SBO:0000297
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_471c7f7e_9b21_4d12_bcd5_7281215c4607
initial concentration: NaN
is: P38571
name: LIPA
is encoded by: hsa:3988
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_e72ff9c5_96d7_42f6_96ad_a1b31c5f65e9
constant: false
is: SBO:0000297
type: Species
initial concentration: NaN
boundary condition: true
name: IDH3A:IDH3B:IDH3G
is encoded by: hsa:3420
initial amount: NaN
has only substance units: false

metaM taur e
is: CHEBI:3544
has only substance units: false
type: Species
boundary condition: false
constant: false
is: HMDB00251
notes: FORMULA: C2H7NO3S CHARGE: 0
is: SBO:0000247
is: C00245
name: Taurine
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_b3e74b08_e2cd_4356_af83_e5b4c3617828
type: Species
initial amount: NaN
is encoded by: hsa:53354
boundary condition: true
name: PANK1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false

metaM 3hdececrn e
has only substance units: false
constant: false
initial concentration: 1.0
name: 3-hydroxyhexadecenoylcarnitine
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C23H43NO5 CHARGE: 0
is: HMDB02068
initial amount: NaN

metaM adpac c
boundary condition: false
initial concentration: 1.0
name: adipic acid
type: Species
constant: false
notes: FORMULA: C6H8O4 CHARGE: -2
has only substance units: false
is: HMDB00448
is: SBO:0000247
initial amount: NaN

metaR RE0453C
is: SBO:0000176
name: RE0453
type: Reaction
product: MODEL1310110057#
reversible: true
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110057#
fast: false

metaM h l
is: http://identifiers.org/pubchem.compound/3380
notes: FORMULA: H CHARGE: 1 INCHI: "
type: Species
name: proton
is: C00080
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:24636
initial concentration: 1.0
constant: false

metaR NDPK2n
reversible: true
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
reactant: MODEL1310110057#
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
type: Reaction
is: SBO:0000176

metaM lgnc c
boundary condition: false
is: CHEBI:31014
name: lignocerate
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB02003
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_b9d1f442_c481_40d9_aecf_962345c8811d
initial amount: NaN
initial concentration: NaN
name: BLVRB
is: SBO:0000252
is encoded by: hsa:645
type: Species
is: P30043
constant: false
boundary condition: true
has only substance units: false

metaR HISD
fast: false
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
product: MODEL1310110057#
reversible: false
name: histidase
type: Reaction
modifier: MODEL1310110057#
is described by: ECO:0000269
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.3.1.3

http://identifiers.org/biomodels.db/MODEL1310110057#_4f03bbe6_fb4f_4000_8f8e_9131cdc5461c
is: Q9Y345
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
name: SLC6A5
type: Species
is: SBO:0000252
is encoded by: hsa:9152
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_32ce3d32_c40d_4af4_a800_8ca9851582c1
is: SBO:0000297
initial amount: NaN
initial concentration: NaN
has part: Q15102
has only substance units: false
is encoded by: hsa:5050
has part: A8DPS7
name: PAFAH1B2:PAFAH1B3
constant: false
is encoded by: hsa:5049
boundary condition: true
type: Species

metaM tdchola x
initial concentration: 1.0
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
name: taurochenodeoxycholate
constant: false
boundary condition: false
is: CHEBI:9407
has only substance units: false
is: SBO:0000247
is: HMDB00951
initial amount: NaN
type: Species

metaM malcoa c
is: CHEBI:57384
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
type: Species
name: Malonyl-CoA
boundary condition: false
is: HMDB01175
initial concentration: 1.0
constant: false
initial amount: NaN
is: C00083
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_218e3693_4a47_4579_887d_1568fe8bb8e7
name: OGDH
has only substance units: false
is: SBO:0000252
is: B4E3E9
initial concentration: NaN
is encoded by: hsa:4967
boundary condition: true
constant: false
initial amount: NaN
type: Species

metaM taur c
is: CHEBI:3544
initial amount: NaN
notes: FORMULA: C2H7NO3S CHARGE: 0
is: HMDB00251
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: C00245
name: Taurine
has only substance units: false
boundary condition: false

metaM maltpt e
type: Species
has only substance units: false
is: C02052
is: SBO:0000247
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
constant: false
is: http://identifiers.org/pubchem.compound/5141
initial amount: NaN
boundary condition: false
is: HMDB01296
name: maltopentaose
initial concentration: 1.0

metaR SIAASE4ly
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110057#
is described by: ECO:0000000
fast: false
product: MODEL1310110057#
name: sialidase, lysosomal
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4

metaM prostgi2 e
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
boundary condition: false
initial concentration: 1.0
is: HMDB01335
is: SBO:0000247
name: prostaglandin I2(1-)
constant: false
is: CHEBI:57403

metaM ipdp c
type: Species
initial concentration: 1.0
initial amount: NaN
is: C00129
is: CHEBI:128769
is: HMDB01347
is: SBO:0000247
constant: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
name: Isopentenyl diphosphate
has only substance units: false
boundary condition: false

metaR TETDEC2CRNe
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of tetradecadienoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_3ef26dc5_0002_438a_b842_14a0ca7f2157
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P48067
is: SBO:0000252
name: SLC6A9
is encoded by: hsa:6536
type: Species
has only substance units: false
constant: false

metaM nadp m
is: SBO:0000247
type: Species
is: C00006
is: HMDB00217
name: Nicotinamide adenine dinucleotide phosphate
initial amount: NaN
is: CHEBI:58349
boundary condition: false
constant: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
initial concentration: 1.0
has only substance units: false

metaM 56dura c
name: 5,6-dihydrouracil
initial amount: NaN
is: CHEBI:15901
boundary condition: false
is: HMDB00076
constant: false
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_9b2ca92d_4d1a_4f55_be0b_257578fb1f8f
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: UGP2
has only substance units: false
constant: false
is encoded by: hsa:7360
boundary condition: true

metaR SBTR
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.1.1.2
name: D-sorbitol reductase
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.21
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_77c2cb51_575b_4da7_999d_22990c2dff9a
has only substance units: false
is encoded by: hsa:51727
initial amount: NaN
is: B2R6S5
is: SBO:0000252
name: CMPK1
type: Species
constant: false
boundary condition: true
initial concentration: NaN

metaR LNELDCCRNt
reactant: MODEL1310110057#
fast: false
reversible: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is: SBO:0000185
name: transport into the mitochondria (carnitine)
is described by: ECO:0000000
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#

metaM orot5p c
is: SBO:0000247
is: HMDB00218
has only substance units: false
is: C01103
is: CHEBI:57538
boundary condition: false
initial concentration: 1.0
name: Orotidine 5'-phosphate
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103

metaM pyr x
type: Species
is: CHEBI:15361
name: pyruvate
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3324
is: C00022
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00243
constant: false
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022

http://identifiers.org/biomodels.db/MODEL1310110057#_f427ff7c_43d7_42f1_8dbc_7dd2dfac0028
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:23533
is: Q8WYR1
name: PIK3R5

metaR sink tetdece1coa LPAREN c RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDECE1COASINK
type: Reaction

metaR r2509
reactant: MODEL1310110057#
product: MODEL1310110057#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
kinetic law: MODEL1310110057#
name: Utilized transport
is described by: ECO:0000000
type: Reaction
fast: false

metaM 13 cis retn r
boundary condition: false
is: HMDB06219
constant: false
is: http://identifiers.org/pubchem.compound/7847414
has only substance units: false
name: 13-cis-retinoate
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
is: D00348
is: SBO:0000247
initial concentration: 1.0
type: Species

metaM thcholstoic c
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:18402
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
constant: false
is: HMDB03873
is: SBO:0000247

metaR RBFK
fast: false
kinetic law: MODEL1310110057#
name: riboflavin kinase
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110057#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.26
is: SBO:0000176
product: MODEL1310110057#
modifier: MODEL1310110057#

metaM l2n2m2mn l
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:12936
is: HMDB00143
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C54H91N3O41 CHARGE: 0
constant: false
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)

metaR DCSPTN1CPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
name: carnitine transferase
fast: false
product: MODEL1310110057#
modifier: MODEL1310110057#

metaR ALACYSNaEx
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110057#
is: SBO:0000185
fast: false
reactant: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

http://identifiers.org/biomodels.db/MODEL1310110057#_7f8bc2b3_239e_4182_9b9e_3c1507dedc89
constant: false
is encoded by: hsa:64600
boundary condition: true
has only substance units: false
name: PLA2G2F
is: Q9BZM2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species

metaM h g
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
name: proton
is: CHEBI:24636

metaM 6hoxmelatn c
type: Species
is: C05643
name: 6-Hydroxymelatonin
boundary condition: false
is: http://identifiers.org/pubchem.compound/7954
initial amount: NaN
constant: false
notes: FORMULA: C13H16N2O3 CHARGE: 0 INCHI: InChI=1/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C05643
is: SBO:0000247
initial concentration: 1.0
is: HMDB04081
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_a4a3c80f_d809_4e45_a146_da63d43440fa
constant: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:1374
is: SBO:0000252
name: CPT1A
initial concentration: NaN
is: Q8WZ48
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_b475606f_1847_4f47_bfde_0b2c5ca93e1e
constant: false
initial concentration: NaN
is: Q12882
type: Species
is encoded by: hsa:1806
name: DPYD
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM prostgi2 c
type: Species
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: prostaglandin I2(1-)
is: HMDB01335
is: SBO:0000247
constant: false
is: CHEBI:57403

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

metaM lnlnca r
is: CHEBI:32387
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
initial amount: NaN
type: Species
is: HMDB01388
constant: false
initial concentration: 1.0
has only substance units: false
name: alpha-linolenate
boundary condition: false

metaM 5tedtricoa x
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: HMDB02288
name: 5,8,11-tetradecatrienoylcoa
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_a39f027a_0402_47f3_ae93_28d2ded93421
initial amount: NaN
name: RBKS
is: Q9H477
has only substance units: false
is encoded by: hsa:64080
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252

metaR r2508
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000185
name: Utilized transport
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110057#

metaM adp x
type: Species
boundary condition: false
is: SBO:0000247
name: ADP(3-)
is: HMDB01341
is: CHEBI:456216
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_be718b67_9a47_44bd_8587_2dc78696858a
type: Species
is: Q9Y217
is encoded by: hsa:9107
initial concentration: NaN
name: MTMR6
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_09620825_b3f3_4b2e_8704_afe14fe7e09f
name: PLCE1
initial concentration: NaN
type: Species
is: Q9P212
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:51196
boundary condition: true

metaR 34HPPte
is described by: ECO:0000134
type: Reaction
reversible: true
name: Transport of 3-(4-hydroxyphenyl)pyruvate
is: SBO:0000185
product: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_bb9a8b2e_a33f_4f34_b64d_ffa6c95fc190
type: Species
name: B3GALT5
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:10317
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_6ae9041e_ea6d_498e_aded_c08efe912ebd
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:127
name: ADH4
is: P08319
type: Species
initial concentration: NaN
initial amount: NaN

metaR DCSPTN1CPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
is: SBO:0000176
fast: false
product: MODEL1310110057#
name: carnitine O-palmitoyltransferase
type: Reaction

metaR ARACHCRNt
is described by: ECO:0000000
fast: false
product: MODEL1310110057#
is: SBO:0000185
reversible: false
modifier: MODEL1310110057#
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110057#_d696caf9_4b05_4b70_a568_1df11a5c9710
name: OGDH
type: Species
initial concentration: NaN
is encoded by: hsa:4967
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is: Q02218

metaM orot c
initial concentration: 1.0
boundary condition: false
is: HMDB00226
initial amount: NaN
name: Orotate
is: CHEBI:30839
is: C00295
constant: false
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295

metaR IVCOAACBP
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Isovaleryl-CoA from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_57ad9b33_ad78_4cfb_910d_02e9f6b10937
is: SBO:0000297
has part: P16499
is encoded by: hsa:5145
name: PDE6A:PDE6H:PDE6B
has part: B7Z9T9
boundary condition: true
is encoded by: hsa:5158
constant: false
initial amount: NaN
is encoded by: hsa:5149
has part: Q13956
initial concentration: NaN
has only substance units: false
type: Species

metaR FATP8t
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000269
is: SBO:0000185
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
product: MODEL1310110057#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.7
name: fatty acid electroneutral transport
type: Reaction
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
modifier: MODEL1310110057#

metaR r2507
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
reversible: true
name: Utilized transport
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false

metaR ASPTAm
reactant: MODEL1310110057#
name: aspartate transaminase
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
product: MODEL1310110057#
type: Reaction
reversible: true
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110057#_94cce4f4_8beb_4a86_983a_c2035c698ca6
type: Species
has only substance units: false
is encoded by: hsa:8897
initial concentration: NaN
name: MTMR3
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

metaR r0926
reactant: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
is described by: ECO:0000000
product: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
is: SBO:0000185
reversible: false
name: Postulated transport reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_b20d5964_2b39_46e4_bef1_45ab8dfb09d7
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:4128
is: Q53YE7
has only substance units: false
name: MAOA

metaR 34DHPHEt
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:NCD
kinetic law: MODEL1310110057#
type: Reaction
name: 3,4-Dihydroxy-L-phenylalanine transport
modifier: MODEL1310110057#
fast: false
reversible: true

metaM dcsptn1coa m
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205483
is: HMDB06513
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
type: Species
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: C16173
boundary condition: false

metaR ORNt4m
type: Reaction
reversible: true
modifier: MODEL1310110057#
is described by: ECO:0000269
product: MODEL1310110057#
name: ornithine mitochondrial transport exchange with citruline
fast: false
reactant: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_4a46ab9d_79a0_4a4c_990d_543b45552348
initial concentration: NaN
name: PDE9A
is: SBO:0000252
is encoded by: hsa:5152
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
constant: false

metaR B3GNT32g
reversible: false
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110057#
fast: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_b773fefd_ca1d_4eb9_832b_049d3691b06c
initial concentration: NaN
is: F5GWS5
constant: false
boundary condition: true
is: SBO:0000252
type: Species
name: ADCY10
has only substance units: false
initial amount: NaN
is encoded by: hsa:55811

metaM HC02187 c
has only substance units: false
is: SBO:0000247
name: reverse-triiodthyronine
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:28774
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
constant: false
type: Species

metaR CITt4 2
modifier: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000269
name: citrate transport via sodium symport
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110057#_87f45f4f_c78b_4e1d_8367_58f362a384f8
is encoded by: hsa:AI480132
name: _AI480132_1_c
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species

metaR TKT2
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is described by: ECO:0000000
is: SBO:0000176
reversible: true
name: transketolase
is version of: http://identifiers.org/ec-code/2.2.1.1
product: MODEL1310110057#
modifier: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
type: Reaction

metaM 3sala m
type: Species
has only substance units: false
is: CHEBI:61085
initial amount: NaN
is: SBO:0000247
is: C00606
initial concentration: 1.0
constant: false
name: 3-sulfino-L-alanine (1-)
boundary condition: false
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606

http://identifiers.org/biomodels.db/MODEL1310110057#_c00a8736_eb72_4ae9_928b_3181bbcdf6b0
has only substance units: false
boundary condition: true
is: P28330
name: ACADL
type: Species
is encoded by: hsa:33
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

metaR CSCPASEly
reversible: false
kinetic law: MODEL1310110057#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reactant: MODEL1310110057#
is described by: ECO:0000000
name: chondroitin sulfate C proteoglycan protease, lysosome (endosome)
product: MODEL1310110057#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_1d6343f5_f055_49ce_8298_fafa5732a4fb
name: SLC29A1
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2030
type: Species
is: Q99808
boundary condition: true
initial amount: NaN
constant: false

metaM dad 2 e
is: HMDB00101
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
type: Species
initial amount: NaN
initial concentration: 1.0
name: 2-deoxyadenosine
is: SBO:0000247
constant: false
is: CHEBI:17256
boundary condition: false
has only substance units: false

metaR L LACt4r
fast: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
name: L-lactate reversible transport via sodium symport
reversible: true
product: MODEL1310110057#

metaR r0629
reversible: true
product: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.1
is: SBO:0000176
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.22
reactant: MODEL1310110057#
is described by: ECO:0000000
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:

metaR FAOXC5OHc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: (3-hydroxyisovalerylcoa-->3-hydroxyisovalerylcarnitine)c
type: Reaction

metaR TMNDNCCRNt
is: SBO:0000185
kinetic law: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
reversible: false
name: transport into the mitochondria (carnitine)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
modifier: MODEL1310110057#
reactant: MODEL1310110057#

metaR C140CPT1
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of myristoylcarnitine
type: Reaction

metaR GDPtg
kinetic law: MODEL1310110057#
is: SBO:0000185
reactant: MODEL1310110057#
fast: false
product: MODEL1310110057#
is described by: ECO:0000000
name: GDP intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_562eb472_64fe_4013_aa8f_74fc2e09d6dc
is: P57103
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:6547
initial concentration: NaN
name: SLC8A3
initial amount: NaN
type: Species

metaR AG13T7g
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110057#
modifier: MODEL1310110057#
product: MODEL1310110057#
reversible: false
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaM 3hpp m
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
initial concentration: 1.0
is: HMDB00700
is: CHEBI:16510
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
constant: false
name: 3-hydroxypropionate

http://identifiers.org/biomodels.db/MODEL1310110057#_ceacc4d6_efb9_4477_b81e_fa31817d70a5
constant: false
is encoded by: hsa:2731
boundary condition: true
is: P23378
initial concentration: NaN
name: GLDC
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN

metaM 5dhf e
constant: false
initial amount: NaN
name: pentaglutamyl folate (DHF)
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
type: Species
has only substance units: false
is: HMDB06487
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaM ttdca c
boundary condition: false
is: HMDB00806
initial concentration: 1.0
type: Species
has only substance units: false
name: myristate
initial amount: NaN
constant: false
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
is: SBO:0000247
is: CHEBI:30807

http://identifiers.org/biomodels.db/MODEL1310110057#_47b74bb1_eb54_4bd8_8413_3695a8cce343
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
name: _AI924226_1_m
boundary condition: true
is encoded by: hsa:AI924226
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_metaM_acglcgalacglcgal14acglcgalgluside_hs_g
name: (Gal)3 (Glc)1 (GlcNAc)3 (Cer)1
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:26174
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_557eb4d8_c555_4377_bf24_195a3c8ff4da
constant: false
is encoded by: hsa:8654
boundary condition: true
name: PDE5A
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaM bilglcur c
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
name: mono(glucosyluronic acid)bilirubin(2-)
boundary condition: false
is: CHEBI:57767
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_afea01f4_9ecf_4efc_af66_e7df66a6c188
initial concentration: NaN
initial amount: NaN
is: Q9Y2Z9
is encoded by: hsa:51004
type: Species
is: SBO:0000252
boundary condition: true
name: COQ6
has only substance units: false
constant: false

metaR GLCURtly
reactant: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
fast: false
kinetic law: MODEL1310110057#
is described by: ECO:0000269
modifier: MODEL1310110057#
is: SBO:0000185
name: glucuronate transport into lysososme
type: Reaction
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_2fecace1_5004_44f3_80b6_60aabb00d2e2
initial concentration: NaN
constant: false
has only substance units: false
is: Q08M29
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:2651
name: GCNT2

metaM lnlnca e
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:32387
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB01388
name: alpha-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_18422b2d_60fe_4dc8_91f0_721304e62baf
initial amount: NaN
boundary condition: true
is encoded by: hsa:10229
is: SBO:0000252
type: Species
constant: false
is: Q99807
initial concentration: NaN
has only substance units: false
name: COQ7

metaR sink dd2coa LPAREN c RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: DD2COASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_25aca7b5_409b_46f0_b6b7_e7a455eeba25
initial concentration: NaN
constant: false
is encoded by: hsa:204
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
name: AK2

metaM 3octdectecoa x
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355
type: Species
constant: false
boundary condition: false
initial amount: NaN
name: 3,6,9,12-octadecatetraenoylcoa
is: SBO:0000247
notes: FORMULA: C39H58N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110057#_bedf2c43_5929_4d2a_8d0d_c59c4dd799f5
constant: false
is encoded by: hsa:954
boundary condition: true
name: ENTPD2
initial amount: NaN
is: Q9Y5L3
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR CITt4 4
is described by: ECO:0000006
fast: false
reversible: true
modifier: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
name: citrate transport via sodium symport
reactant: MODEL1310110057#

metaR r0587
modifier: MODEL1310110057#
reversible: true
kinetic law: MODEL1310110057#
fast: false
is described by: ECO:0000000
product: MODEL1310110057#
is: SBO:0000176
reactant: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM 3mop m
name: 3-methyl-2-oxopentanoate
initial amount: NaN
boundary condition: false
is: CHEBI:28654
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00491
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671

metaR DNDPt10m
product: MODEL1310110057#
reversible: false
reactant: MODEL1310110057#
is: SBO:0000185
kinetic law: MODEL1310110057#
fast: false
modifier: MODEL1310110057#
is described by: ECO:0000269
name: dADP transport via dCDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_2985e3a6_bb3b_403d_85bf_63c08702a988
is encoded by: hsa:8836
initial amount: NaN
initial concentration: NaN
is: Q92820
is: SBO:0000252
constant: false
has only substance units: false
name: GGH
type: Species
boundary condition: true

metaM xoldioloneh c
constant: false
initial amount: NaN
has only substance units: false
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
type: Species
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
initial concentration: 1.0
boundary condition: false
is: HMDB06887
is: CHEBI:2288
is: SBO:0000247

metaM coa r
name: Coenzyme A
has only substance units: false
constant: false
type: Species
is: HMDB01423
is: CHEBI:57287
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: SBO:0000247
is: C00010
initial amount: NaN

metaM 34dhmald c
is: HMDB06242
name: 3,4-Dihydroxymandelaldehyde
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/7903
is: C05577
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_152c9a0a_437a_40b2_9e9b_a6c4d200e27c
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:7359
name: _7359_1_c
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_2a2df107_2b7d_42da_971d_5b0af0c40ed1
boundary condition: true
name: ST3GAL4
is encoded by: hsa:6484
has only substance units: false
initial concentration: NaN
is: Q6IBE6
initial amount: NaN
constant: false
type: Species
is: SBO:0000252

metaR ALAGLYexR
kinetic law: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
is described by: ECO:0000304
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-alanine/glycine reversible exchange
modifier: MODEL1310110057#
fast: false
reversible: true
product: MODEL1310110057#

metaR TKT1
kinetic law: MODEL1310110057#
reversible: true
name: transketolase
fast: false
is described by: ECO:0000000
modifier: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.2.1.1
type: Reaction
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_a04b8423_13f5_4489_9c23_d4c1b5507a00
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
name: HMGCS1
is encoded by: hsa:3157
constant: false
is: Q01581
initial amount: NaN
boundary condition: true

metaM ttdca e
is: HMDB00806
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: tetradecanoate (n-C14:0)
initial amount: NaN
is: C06424
boundary condition: false
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
type: Species
is: CHEBI:30807
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_5b0b8dca_3a38_4513_b5fd_d27e13e8bbfe
is encoded by: hsa:501
type: Species
initial amount: NaN
name: ALDH7A1
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: E7EPT3
constant: false

metaR THRGLNNaEx
name: L-threonine/L-glutamine Na-dependent exchange (Thr-L in)
fast: false
kinetic law: MODEL1310110057#
reversible: false
type: Reaction
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
modifier: MODEL1310110057#
is: SBO:0000185
product: MODEL1310110057#

metaM ala D e
has only substance units: false
is: CHEBI:15570
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: HMDB01310
constant: false
name: D-alanine
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species

metaR RBTt
is described by: ECO:0000000
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reversible: false
product: MODEL1310110057#
name: ribitol transport via passive diffusion
type: Reaction
is: SBO:0000185
fast: false

metaM ha l
name: hyaluronan
is: SBO:0000247
is: CHEBI:16336
constant: false
boundary condition: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0

metaR FAOXC123C102x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)x
type: Reaction

metaM bilglcur e
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
name: mono(glucosyluronic acid)bilirubin(2-)
is: SBO:0000247
boundary condition: false
is: CHEBI:57767
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_e9e5be28_5316_4fb3_a805_76b59ec4d4e8
is: Q8WWX8
initial concentration: NaN
is encoded by: hsa:115584
initial amount: NaN
has only substance units: false
name: SLC5A11
is: SBO:0000252
type: Species
boundary condition: true
constant: false

metaR RE2541E
name: RE2541
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: true

metaR RE1534M
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110057#
is described by: ECO:0000000
type: Reaction
name: RE1534
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
fast: false
is: SBO:0000176

metaR r1423
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
fast: false
reactant: MODEL1310110057#
name: Facilitated diffusion
type: Reaction
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000185
reversible: false
is described by: ECO:0000000

metaR G12MT1 L
fast: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110057#
is: SBO:0000176
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
kinetic law: MODEL1310110057#
is described by: ECO:0000000
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_a40a05e2_79d7_462c_97d9_d1176d43d242
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
name: SLCO1A2
has only substance units: false
initial amount: NaN
is: P46721
is encoded by: hsa:6579

metaR PLA2 2
is: SBO:0000176
notes: GENE_ASSOCIATION: (8398.1) or (5320.1) or (8398.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:9272153,PMID:9417066 NOTES:phosphatidyl choline degradation NJ
kinetic law: MODEL1310110057#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.1.1.4
modifier: MODEL1310110057#
fast: false
name: phospholipase A2
reactant: MODEL1310110057#
reversible: false

metaM tststerones e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1/C19H28O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h11,14-17H,3-10H2,1-2H3,(H,21,22,23)/t14-,15-,16-,17-,18-,19-/m0/s1
has only substance units: false
constant: false
is: HMDB02833
is: SBO:0000247
initial amount: NaN
type: Species
name: testosterone sulfate

metaR LYSOXp
is: SBO:0000176
product: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
is described by: ECO:0000000
type: Reaction
name: L-lysine oxidase, peroxisomal

metaR TAGt
type: Reaction
name: triacylglycerol transport
reversible: true
reactant: MODEL1310110057#
is described by: ECO:0000000
product: MODEL1310110057#
is: SBO:0000185
kinetic law: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110057#_68bef1ad_d748_41a9_95bc_8d8b44efa261
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4125
constant: false
name: MAN2B1
initial amount: NaN
is: O00754
type: Species
has only substance units: false

metaR ABTti
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
product: MODEL1310110057#
fast: false
name: L-arabinitol transport via passive diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
is: SBO:0000185

metaR DNDPt8m
type: Reaction
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
reversible: false
product: MODEL1310110057#
name: dADP transport via dUDP antiport
modifier: MODEL1310110057#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269

metaM prpncoa m
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
boundary condition: false
has only substance units: false
name: acryloyl-CoA(4-)
is: CHEBI:57367
is: SBO:0000247
type: Species
is: HMDB02307
constant: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_a1476656_6e86_4369_86a2_48b1fd2db826
is encoded by: hsa:5152
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
name: PDE9A

http://identifiers.org/biomodels.db/MODEL1310110057#_0c08ed10_82c0_4048_8b64_db7070091cbf
is encoded by: hsa:570
has only substance units: false
is: Q14032
name: BAAT
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_edcdaacc_7622_40f1_8310_bce744cd0eeb
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:2585
constant: false
is: SBO:0000252
name: GALK2
initial concentration: NaN
type: Species
is: Q01415

metaM hepcoa m
is: HMDB12969
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C28H44N7O17P3S CHARGE: -4
is: SBO:0000247
name: heptanoylcoa
type: Species
constant: false
has only substance units: false

metaM HC02187 e
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
is: CHEBI:28774
has only substance units: false
initial concentration: 1.0
name: reverse-triiodthyronine

metaM gpi sig r
is: SBO:0000247
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
notes: FORMULA: Y CHARGE: 0
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00224
is: CHEBI:58190
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_ef3d8098_150d_4543_a349_0b71004c6e28
constant: false
name: GALT
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is: B2RAT6
has only substance units: false
is encoded by: hsa:2592

metaR r1538
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000185
fast: false
modifier: MODEL1310110057#
is described by: ECO:0000000
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
product: MODEL1310110057#
reversible: false
type: Reaction

metaM ksii core4 pre7 g
notes: FORMULA: C75H121N6O56SX CHARGE: -2
boundary condition: false
constant: false
type: Species
name: keratan sulfate II biosynthesis, precursor 7
is: HMDB00175
is: SBO:0000247
is: CHEBI:58053
initial amount: NaN
is: C00130
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_fdcc5c89_56f2_4bf1_8770_a2689a38269b
name: SLC40A1
constant: false
is: Q9NP59
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:30061

metaM 4mptnl m
boundary condition: false
is: CHEBI:17998
type: Species
initial amount: NaN
name: 4-methylpentanal
initial concentration: 1.0
has only substance units: false
is: HMDB01318
constant: false
is: SBO:0000247
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373

metaR 5ADTSTSTERONESULT
is described by: ECO:0000269
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES:NJ
kinetic law: MODEL1310110057#
fast: false
product: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.14
is: SBO:0000176
name: 5alpha-Dihydrotestosterone sulfotransferase
reversible: false

metaR SUCD1m
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
is version of: http://identifiers.org/ec-code/1.3.5.1
fast: false
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
name: succinate dehydrogenase
reversible: true
product: MODEL1310110057#

metaR CSPG Ctly
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000185
fast: false
product: MODEL1310110057#
name: chondroitin sulfate C transport, extracellular to lysosome

metaM hexdiac r
is: SBO:0000247
has only substance units: false
type: Species
name: hexadecanediocacid
initial concentration: 1.0
is: C08260
constant: false
initial amount: NaN
is: HMDB00672
boundary condition: false
notes: FORMULA: C16H28O4 CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110057#_e8730243_5a1b_4c0e_8a8b_51b4aea19a0a
boundary condition: true
name: NDUFV3
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:4731

metaR TCYNTtm
fast: false
reactant: MODEL1310110057#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110057#
product: MODEL1310110057#
name: Thiocyanate transport via diffusion (mitochondrial)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110057#_7a644336_db5a_4cbd_b919_d1bb021f9e7b
is: SBO:0000252
constant: false
is encoded by: hsa:1545
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
name: CYP1B1
is: Q16678

metaR r0627
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110057#
reversible: true
kinetic law: MODEL1310110057#
is described by: ECO:0000000
product: MODEL1310110057#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_aa2fa149_f76c_45df_9594_7b1a4ca168ed
is: O60658
is encoded by: hsa:5151
type: Species
has only substance units: false
initial concentration: NaN
name: PDE8A
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_318210d0_3856_462c_b31a_1a32b7387bf7
constant: false
is encoded by: hsa:4729
has only substance units: false
type: Species
is: P19404
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: NDUFV2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_49d67d12_5c27_4dcd_8ad4_2b1963566da2
is: SBO:0000252
name: SLC27A2
is: O14975
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:11001
boundary condition: true

metaM coa n
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: CHEBI:57287
name: coenzyme A(4-)
is: SBO:0000247
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
boundary condition: false
is: HMDB01423

http://identifiers.org/biomodels.db/MODEL1310110057#_1dedcb00_cc93_48e5_941b_69966e89d664
initial concentration: NaN
name: VNN3:VNN2:VNN1
is: SBO:0000297
has only substance units: false
is encoded by: hsa:55350
constant: false
boundary condition: true
type: Species
initial amount: NaN

metaR CHSTEROLtrc
reactant: MODEL1310110057#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110057#
type: Reaction
reversible: true
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
name: transport of cholesterol into the cytosol
is described by: ECO:0000134

metaM fadh2 m
is: SBO:0000247
name: Flavin adenine dinucleotide reduced
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58307
type: Species
boundary condition: false
has only substance units: false
constant: false
is: HMDB01197
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: C01352

metaR KHte
kinetic law: MODEL1310110057#
name: KHte
reactant: MODEL1310110057#
is: SBO:0000185
type: Reaction
product: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
is described by: ECO:0000134

metaR r0584
fast: false
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110057#
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110057#
type: Reaction

metaR 4HGLSDm
reversible: true
fast: false
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
is: SBO:0000176
type: Reaction
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000212
product: MODEL1310110057#
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.5.1.12

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaM dhcholoylcoa x
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA
has only substance units: false
is: HMDB06895
constant: false
boundary condition: false
is: CHEBI:27393

http://identifiers.org/biomodels.db/MODEL1310110057#_05fa9d28_79ef_4d4b_b31c_2163f7b8d75e
boundary condition: true
is encoded by: hsa:3291
name: HSD11B2
initial concentration: NaN
is: P80365
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_43f9d260_9e50_4fdc_9b75_97eebd75a8f4
type: Species
is encoded by: hsa:284098
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
name: PIGW
is: Q7Z7B1
boundary condition: true

metaM L2aadp6sa c
is: SBO:0000247
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
initial concentration: 1.0
boundary condition: false
constant: false
name: L-allysine
is: CHEBI:17917
type: Species
is: HMDB01263
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_d6927412_bb03_470c_b8b8_929fd7f37c40
type: Species
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: Q7GXZ8
is encoded by: hsa:4513
initial concentration: NaN
name: COX2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_576c72b9_81f4_47dc_af91_c247634f7bcb
has only substance units: false
is encoded by: hsa:AI620219
boundary condition: true
constant: false
name: _AI620219_1_c
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

metaR CYSSERNaEx
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
reactant: MODEL1310110057#
type: Reaction
reversible: false
name: L-serine/L-cysteine Na-dependent exchange (Cys-L in)
product: MODEL1310110057#
is described by: ECO:0000269
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is: SBO:0000185

metaR ACGBGBSIDEtg
reversible: true
kinetic law: MODEL1310110057#
is described by: ECO:0000000
name: acgbgbside hs intracellular transport
reactant: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is: SBO:0000185
fast: false

metaM dnad c
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
is: C00857
has only substance units: false
name: Deamino-NAD+
initial concentration: 1.0
initial amount: NaN
is: HMDB01179
type: Species
is: CHEBI:18304
constant: false
boundary condition: false
is: SBO:0000247

metaR DGSNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
kinetic law: MODEL1310110057#
is: SBO:0000185
reversible: true
reactant: MODEL1310110057#
is described by: ECO:0000000
product: MODEL1310110057#
type: Reaction
fast: false
name: deoyguanosine transport via diffusion

metaR r0733
reactant: MODEL1310110057#
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
modifier: MODEL1310110057#
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.5.1.12
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaM coa m
is: CHEBI:57287
constant: false
name: Coenzyme A
is: SBO:0000247
initial concentration: 1.0
is: C00010
has only substance units: false
type: Species
boundary condition: false
is: HMDB01423
initial amount: NaN
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010

http://identifiers.org/biomodels.db/MODEL1310110057#_79da4b1d_9fb5_4fe7_ae4d_ec2d2ca3d227
is: SBO:0000252
is: Q96P26
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:93034
name: NT5C1B
type: Species
constant: false

metaR ENGASE2ly
reactant: MODEL1310110057#
name: endo-beta-N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110057#_0f3cb560_e8e6_4613_b76e_03cfddcd64cc
has only substance units: false
is: SBO:0000252
name: ATP5G3
type: Species
is encoded by: hsa:518
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false

metaR RE2625M
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000176
product: MODEL1310110057#
name: RE2625
modifier: MODEL1310110057#
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_cec6cd00_504d_452f_bfbd_9ca9a0aa6e61
is: SBO:0000252
name: SLC25A2
constant: false
has only substance units: false
is: Q9BXI2
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:83884
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_47e5531c_05d6_4735_9fba_20235716fd00
name: OCRL
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4952
has only substance units: false
initial amount: NaN

metaM retn e
type: Species
is: HMDB01852
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
name: all-trans-retinoate
boundary condition: false
is: CHEBI:35291
initial concentration: 1.0
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777

http://identifiers.org/biomodels.db/MODEL1310110057#_7770b731_d51e_44c1_8863_948e2508ee27
name: FOLR1
is encoded by: hsa:2348
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN

metaM phyt c
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
name: phytanate
is: CHEBI:37257
is: HMDB00801
initial amount: NaN

metaR r0734
reversible: false
is: SBO:0000176
reactant: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110057#
product: MODEL1310110057#
type: Reaction

metaR r0474
fast: false
product: MODEL1310110057#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#
is: SBO:0000176
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

metaM hdcea c
initial concentration: 1.0
has only substance units: false
type: Species
name: Hexadecenoate (n-C16:1)
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB03229
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: CHEBI:32372
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110057#_53f884d0_1781_41ba_bb67_2c0c35d4a55d
has only substance units: false
boundary condition: true
is: P24666
is encoded by: hsa:52
initial amount: NaN
name: ACP1
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN

metaM dcsptn1coa c
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205483
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
constant: false
initial concentration: 1.0
type: Species
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
boundary condition: false
is: HMDB06513
is: C16173

metaR r1429
fast: false
product: MODEL1310110057#
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_39cb92d2_11e1_4c0a_b50a_1811e88349b4
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q53Y25
initial amount: NaN
name: GCK
has only substance units: false
is encoded by: hsa:2645

metaR r1291
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction
is: SBO:0000185
name: Postulated transport reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110057#
product: MODEL1310110057#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_e9dda58a_4d42_4f44_89a7_655a0173d43d
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1351
type: Species
name: COX8A
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q53XN1

metaR r0735
type: Reaction
is: SBO:0000176
modifier: MODEL1310110057#
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: true
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is described by: ECO:0000000
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3

metaM taur x
type: Species
is: CHEBI:15891
constant: false
initial amount: NaN
name: taurine
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00251
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245

http://identifiers.org/biomodels.db/MODEL1310110057#_74099183_2ace_4915_9562_1ec037a85b36
type: Species
boundary condition: true
is encoded by: hsa:728226
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: _728226_1_m
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_7e0cf4be_5863_4c15_81d5_6b3fdf35c33e
constant: false
is: SBO:0000252
is encoded by: hsa:2954
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: A6NED0
name: GSTZ1
has only substance units: false

metaR r0475
reversible: true
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110057#
is: SBO:0000176
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reactant: MODEL1310110057#
type: Reaction

metaR RE2954C
modifier: MODEL1310110057#
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000000
reversible: true
fast: false
name: RE2954
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.40
is: SBO:0000176
type: Reaction

metaR DCTPtn
kinetic law: MODEL1310110057#
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110057#
reversible: true
name: dCTP diffusion in nucleus
is: SBO:0000185
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaR OCTAt
kinetic law: MODEL1310110057#
name: Octanoate transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
reactant: MODEL1310110057#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110057#
type: Reaction

metaR 34DHOXPEGOX
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.99.24
modifier: MODEL1310110057#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.1
notes: GENE_ASSOCIATION: (130.1) or (127.1) or (125.1 and 124.1) or (131.1) or (126.1 and 124.1) or (128.1) or (137872.1) or (125.1 and 126.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.1.1.1 Confidence Level: 4 AUTHORS: PMID:3466164 NOTES:SAB
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110057#
product: MODEL1310110057#
kinetic law: MODEL1310110057#
name: 3,4-Dihydroxyphenylethyleneglycol:NAD+ oxidoreductase
fast: false

metaR GALASE17ly
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
name: beta-galactosidase, lysosomal

metaR r0021
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.6.1.5
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
reactant: MODEL1310110057#
product: MODEL1310110057#
modifier: MODEL1310110057#

metaR G14T16g
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

metaR NCKt
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110057#
fast: false
name: Na+/Ca2+-K+ exchange
reversible: true
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
product: MODEL1310110057#
is described by: ECO:0000269
reactant: MODEL1310110057#
modifier: MODEL1310110057#

metaM dd3coa x
name: 3-dodecenoylcoa
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
is: HMDB04257

metaR r1428
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
name: Free diffusion
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: true
fast: false
product: MODEL1310110057#

metaM tststerones c
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1/C19H28O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h11,14-17H,3-10H2,1-2H3,(H,21,22,23)/t14-,15-,16-,17-,18-,19-/m0/s1
name: testosterone sulfate
type: Species
is: HMDB02833
initial concentration: 1.0

metaR RE0689E
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is: SBO:0000176
name: RE0689
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.22
product: MODEL1310110057#
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
reversible: false
reactant: MODEL1310110057#
is described by: ECO:0000000

metaR FRUt4
is: SBO:0000185
is described by: ECO:0000269
name: D-fructose transport via sodium cotransport
product: MODEL1310110057#
type: Reaction
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
fast: false
reversible: true
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaR FAOXC164GC163m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_9bdeb8b6_92b3_4327_8f3b_c0e09eb65a0f
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is encoded by: hsa:AU149534
initial amount: NaN
name: _AU149534_1_e
initial concentration: NaN

metaM fum c
name: Fumarate
type: Species
boundary condition: false
is: HMDB00134
initial concentration: 1.0
initial amount: NaN
is: CHEBI:29806
constant: false
is: SBO:0000247
is: C00122
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
has only substance units: false

metaR r0022
kinetic law: MODEL1310110057#
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
modifier: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.7
reactant: MODEL1310110057#
is: SBO:0000176
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_0c17e0f7_e766_4211_844e_ce41e1125d18
name: SULT1A3
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6818
boundary condition: true
is: P50224
initial concentration: NaN

metaR TSTSTERONEt
fast: false
name: Testosterone transport
product: MODEL1310110057#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
kinetic law: MODEL1310110057#
is: SBO:0000185

metaR C4STMO2r
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.170
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.72
name: C-4 methyl sterol oxidase
reactant: MODEL1310110057#
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
product: MODEL1310110057#
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_77e7f42e_7f71_46e2_8128_58e8c0dc950f
initial concentration: NaN
constant: false
has only substance units: false
is: Q3KQV9
name: UAP1L1
boundary condition: true
is encoded by: hsa:91373
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_4f5a4b7d_865a_40e0_a691_10258737e914
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:513
boundary condition: true
name: ATP5D
is: SBO:0000252
constant: false
initial concentration: NaN

metaR ST8SIA11
reversible: false
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.99.8
name: Beta-galactoside alpha-2,3-sialyltransferase
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
kinetic law: MODEL1310110057#
fast: false
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_e9d7a742_b0c5_4642_b1ac_c2101dcdbf99
boundary condition: true
name: AMY1B
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P04745
type: Species
is encoded by: hsa:277
constant: false
is: SBO:0000252

metaR r1968
is: SBO:0000185
reactant: MODEL1310110057#
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: false
type: Reaction
product: MODEL1310110057#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110057#_cfc35a34_ea8b_43ac_86c5_a133e68249e4
initial amount: NaN
type: Species
is encoded by: hsa:259230
has only substance units: false
initial concentration: NaN
name: SGMS1
is: D3DWC4
boundary condition: true
constant: false
is: SBO:0000252

metaR PItg
type: Reaction
reactant: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false
is: SBO:0000185
fast: false
product: MODEL1310110057#
kinetic law: MODEL1310110057#
name: phosphate transport, Golgi apparatus

metaM lnlnca c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: SBO:0000247
constant: false
boundary condition: false
name: alpha-linolenate
is: CHEBI:32387
type: Species
is: HMDB01388

metaM ksi deg8 l
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00143
is: CHEBI:12936
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: keratan sulfate I, degradation product 8

metaM gln L m
boundary condition: false
initial concentration: 1.0
is: HMDB00641
type: Species
name: L-glutamine
is: CHEBI:18050
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
constant: false
initial amount: NaN

metaR EX 11 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 11-cis-retinol exchange
type: Reaction

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaM ala D c
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
has only substance units: false
boundary condition: false
type: Species
is: HMDB01310
name: D-alanine
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15570
is: SBO:0000247

metaR NADH2 u10m
type: Reaction
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
is: SBO:0000185
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.6.5.3
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
reversible: false
name: NADH dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.6.99.3
product: MODEL1310110057#

metaR XOLTRIOLtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
product: MODEL1310110057#
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: true
is: SBO:0000185
type: Reaction
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110057#_763546fd_fc55_43bf_b432_645533517b21
is: Q9H310
name: RHBG
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:57127
initial amount: NaN

metaR DAGKn hs
notes: GENE_ASSOCIATION: (8525.1) or (9162.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
reactant: MODEL1310110057#
name: Diacylglycerol phosphate kinase (homo sapiens)
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.1.107
is described by: ECO:0000269
type: Reaction
reversible: true
modifier: MODEL1310110057#
fast: false
product: MODEL1310110057#

metaR PGK
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.2.3
name: phosphoglycerate kinase
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
fast: false
is: SBO:0000176

metaM lcts g
has only substance units: false
initial amount: NaN
constant: false
name: lactose
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00186
type: Species
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11?,12+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
is: CHEBI:17716

metaR ST8SIA12
product: MODEL1310110057#
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.99.8
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
name: Beta-galactoside alpha-2,3-sialyltransferase
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000176
reversible: false

metaR ACGBGBSIDEtl
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
fast: false
is described by: ECO:0000000
name: acgbgbside hs intracellular transport
kinetic law: MODEL1310110057#
reversible: true
type: Reaction
product: MODEL1310110057#
is: SBO:0000185

metaR r0921
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12006583,PMID:1260500,PMID:12838422,PMID:14747464,PMID:16595656,PMID:168203,PMID:17187757,PMID:17279066,PMID:3728675,PMID:6778226,PMID:7419607,PMID:7479738,PMID:8438778 NOTES:
reversible: false
is described by: ECO:0000000
name: Postulated transport reaction
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
product: MODEL1310110057#

metaM fadh2 c
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: HMDB01197
initial amount: NaN
is: SBO:0000247
name: FADH2(2-)
constant: false
boundary condition: false
is: CHEBI:58307

metaM ksi deg14 l
is: CHEBI:12936
is: SBO:0000247
is: HMDB00143
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
name: keratan sulfate I, degradation product 14
has only substance units: false
notes: FORMULA: C166H267N11O145S8 CHARGE: -8

metaR RE0453N
name: RE0453
is: SBO:0000176
reversible: true
reactant: MODEL1310110057#
product: MODEL1310110057#
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000000
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_5e56e7d4_c79e_4f07_bf42_c298819845c2
is: P33121
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2180
name: ACSL1
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species

metaR PYK
reactant: MODEL1310110057#
is described by: ECO:0000134
type: Reaction
reversible: false
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.40
product: MODEL1310110057#
name: pyruvate kinase
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:

metaM dad 2 c
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: 2-deoxyadenosine
is: HMDB00101
is: SBO:0000247
boundary condition: false
type: Species
constant: false
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
is: CHEBI:17256

http://identifiers.org/biomodels.db/MODEL1310110057#_478b38d2_f10b_4b25_abb2_4e083f1a1613
is: Q9UNU6
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:1582
initial concentration: NaN
constant: false
name: CYP8B1
has only substance units: false

metaR ME2
type: Reaction
product: MODEL1310110057#
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.1.1.40
is described by: ECO:0000000
name: malic enzyme (NADP)
notes: GENE_ASSOCIATION: (4199.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:
kinetic law: MODEL1310110057#
fast: false
reversible: false
modifier: MODEL1310110057#
is: SBO:0000176

metaR SUCCtp
name: succinate transporter, peroxisome
kinetic law: MODEL1310110057#
is: SBO:0000185
fast: false
product: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
is described by: ECO:0000000

metaR 7DHCHSTEROLtr
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is described by: ECO:0000000
name: cholesterol precursor intracellular transport
product: MODEL1310110057#
reversible: true
reactant: MODEL1310110057#

metaM 6pgc r
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:58759
has only substance units: false
is: HMDB01316
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
name: 6-phosphonatooxy-D-gluconate

metaR A MANASEly
name: alpha-mannosidase, lysosomal
kinetic law: MODEL1310110057#
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.24
reactant: MODEL1310110057#
product: MODEL1310110057#
modifier: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD

metaR FAOXC184C164x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_198cf6c2_274e_4776_af16_0ed299cfb63f
constant: false
boundary condition: true
is: B3KT19
has only substance units: false
is encoded by: hsa:5295
initial concentration: NaN
initial amount: NaN
name: PIK3R1
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_ba002275_bd49_4bfd_b941_25115bc43689
initial concentration: NaN
name: DHODH
constant: false
is: Q02127
type: Species
is encoded by: hsa:1723
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true

metaM coa g
is: SBO:0000247
is: CHEBI:57287
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: HMDB01423
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: coenzyme A(4-)

metaM ksi pre11 g
is: CHEBI:28067
is: SBO:0000247
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 11
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
has only substance units: false
constant: false
type: Species

metaR LEUGLYHYc
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
product: MODEL1310110057#
name: hydrolysis of leucylglycine
type: Reaction
fast: false
reactant: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000134
reversible: true

metaM prist c
initial amount: NaN
type: Species
constant: false
name: pristanic acid
initial concentration: 1.0
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
boundary condition: false
is: SBO:0000247
is: CHEBI:51340
has only substance units: false
is: HMDB00795

metaM bilirub c
boundary condition: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
constant: false
is: HMDB00054
initial amount: NaN
is: CHEBI:57977
initial concentration: 1.0
type: Species
is: SBO:0000247
name: bilirubin(2-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_c4ea328d_dcbd_4cf5_8b92_f750fb60d3cd
initial concentration: NaN
is encoded by: hsa:9514
initial amount: NaN
is: Q99999
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
constant: false
name: GAL3ST1

metaR r0739
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110057#
modifier: MODEL1310110057#
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_9c0952e8_b1e3_4509_a80d_1379ab5fe296
is: SBO:0000252
is encoded by: hsa:55350
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
name: VNN3
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_db541a88_1c74_431b_bfd1_0eceb5265d65
type: Species
is: Q92959
name: SLCO2A1
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6578
boundary condition: true
initial concentration: NaN

metaM HC01412 m
name: trans-tetradec-2-enoyl-CoA(4-)
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:61405
type: Species
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273

metaR OCDCAtr
product: MODEL1310110057#
name: fatty acid transport via diffusion
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110057#
is: SBO:0000185
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_539097cd_e17e_4a9a_bc08_54e48702ad1c
is: Q8TB61
type: Species
name: SLC35B2
is encoded by: hsa:347734
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true

metaR ACNAMPH
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: N-Acetylneuraminate 9-phosphate phosphohydrolase
kinetic law: MODEL1310110057#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110057#_e00ab473_1ee4_4ea5_89f6_04a0662df0df
name: SLC4A8
is encoded by: hsa:9498
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: E7EML0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_977b2e0c_bc68_4121_8ceb_4bf5455d29e0
initial concentration: NaN
is encoded by: hsa:57835
name: SLC4A5
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false

metaR PGI
is: SBO:0000176
name: glucose-6-phosphate isomerase
modifier: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.1.9
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:

metaM phyt e
name: phytanate
type: Species
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
boundary condition: false
is: CHEBI:37257
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00801
initial amount: NaN
has only substance units: false

metaM lac L x
constant: false
boundary condition: false
is: CHEBI:16651
is: HMDB00190
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: (S)-lactate
initial concentration: 1.0
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177

metaM lcts e
is: CHEBI:17716
is: SBO:0000247
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
is: HMDB00186
type: Species
name: Lactose
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: C00243
boundary condition: false
constant: false

metaR SUCCt2m
is: SBO:0000185
kinetic law: MODEL1310110057#
is described by: ECO:0000269
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: true
modifier: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
name: succinate transport, mitochondrial

metaM retn c
boundary condition: false
is: CHEBI:35291
name: all-trans-retinoate
is: HMDB01852
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
type: Species

metaM 5hoxindoa c
initial concentration: 1.0
type: Species
is: HMDB00763
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H8NO3 CHARGE: -1 INCHI: InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14) HEPATONET_1.0_ABBREVIATION: HC01537 EHMN_ABBREVIATION: C05635
constant: false
is: CHEBI:27823
initial amount: NaN
boundary condition: false
name: 5-Hydroxyindoleacetate

metaR SAMHISTA
fast: false
reactant: MODEL1310110057#
reversible: false
type: Reaction
product: MODEL1310110057#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.1.8
name: S-Adenosyl-L-methionine:histamine N-tele-methyltransferase
modifier: MODEL1310110057#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3176.1) SUBSYSTEM: Histidine metabolism EC Number: 2.1.1.8 Confidence Level: 4 AUTHORS: PMID:7943261 NOTES:SAB R02155
kinetic law: MODEL1310110057#

metaR EX 4pyrdx LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Pyridoxate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_45a2b7df_c954_4286_ab69_a83981e3a739
is: Q99519
has only substance units: false
type: Species
constant: false
is encoded by: hsa:4758
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: NEU1
initial amount: NaN

metaM hpyr c
constant: false
is: SBO:0000247
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
name: 3-hydroxypyruvate
type: Species
boundary condition: false
is: CHEBI:17180
has only substance units: false
is: HMDB01352
initial concentration: 1.0
initial amount: NaN

metaR S6TASE22ly
is: SBO:0000176
product: MODEL1310110057#
reversible: true
name: galactose-6-sulfate sulfatase, lysosomal
fast: false
modifier: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_5c08f301_406c_4374_8ce9_ccbcd6d99af2
name: ESCO1
is encoded by: hsa:114799
constant: false
is: Q5FWF5
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species

metaR NACHEX5ly
product: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
reversible: false
kinetic law: MODEL1310110057#
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
modifier: MODEL1310110057#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR DOLPH Ler
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
fast: false
reactant: MODEL1310110057#
reversible: false
name: Dolichol-phosphate phosphohydrolase, human (liver)
is described by: ECO:0000000
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000176
type: Reaction

metaM bilirub e
initial amount: NaN
name: bilirubin(2-)
is: HMDB00054
is: CHEBI:57977
constant: false
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial concentration: 1.0

metaR RE1573M
product: MODEL1310110057#
is: SBO:0000176
name: RE1573
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
reversible: true
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/5.3.3.8
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_8e41d52a_b549_4aa9_8280_13e9acc7601d
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:AI818585
has only substance units: false
name: _AI818585_1_c

http://identifiers.org/biomodels.db/MODEL1310110057#_fe533d7a_fb46_42ac_8422_a3b693cfd87f
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:8659
name: ALDH4A1
type: Species
initial concentration: NaN
is: SBO:0000252
is: P30038

metaR r1964
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110057#
fast: false
modifier: MODEL1310110057#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110057#_0c63162d_4626_483d_a475_e8d726819af5
name: FUT8
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2530
is: G3V5N0
type: Species

metaM bilglcur r
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: mono(glucosyluronic acid)bilirubin(2-)
constant: false
initial amount: NaN
type: Species
is: CHEBI:57767

http://identifiers.org/biomodels.db/MODEL1310110057#_471ebe82_b52e_4a6d_87fd_f59aebb8002c
initial concentration: NaN
name: NDUFB3
type: Species
is encoded by: hsa:4709
constant: false
has only substance units: false
is: Q6IB80
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_3b7abcaf_1bdd_4a59_a7b7_5cbb5afff6e9
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:10195
name: ALG3
boundary condition: true

metaM tdcoa c
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: HMDB01521
boundary condition: false
initial amount: NaN
is: CHEBI:57385
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
type: Species
constant: false
is: C02593

metaM fru e
constant: false
is: HMDB00660
name: D-Fructose
boundary condition: false
has only substance units: false
is: C00095
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15824
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095

metaR C3DCe
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of malonyl carnitine into extra cellular space
type: Reaction

metaM prostge1 c
is: HMDB01442
is: CHEBI:57397
name: prostaglandin E1(1-)
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM acnamp c
initial amount: NaN
has only substance units: false
name: N-Acetylneuraminate 9-phosphate
boundary condition: false
is: CHEBI:27438
type: Species
is: HMDB06268
constant: false
is: SBO:0000247
notes: FORMULA: C11H17NO12P CHARGE: -3 INCHI: InChI=1S/C11H20NO12P/c1-4(13)12-7-5(14)2-11(19,10(17)18)24-9(7)8(16)6(15)3-23-25(20,21)22/h5-9,14-16,19H,2-3H2,1H3,(H,12,13)(H,17,18)(H2,20,21,22)/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01734 EHMN_ABBREVIATION: C06241
initial concentration: 1.0

metaR r0480
reversible: true
reactant: MODEL1310110057#
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
product: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110057#_c0152d0e_a72d_4e7d_85f1_f91c3090abdf
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10317
name: B3GALT5
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
type: Species

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaR CO2tp
name: CO2 peroxisomal transport
kinetic law: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR PItn
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: phosphate transport, nuclear
reactant: MODEL1310110057#
fast: false
product: MODEL1310110057#
reversible: true
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaR r1298
name: Vesicular transport
reactant: MODEL1310110057#
is: SBO:0000185
kinetic law: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110057#
reversible: false
type: Reaction

metaM pail45p hs n
is: CHEBI:28910
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
constant: false
name: phosphatidylinositol 4,5-bisphosphate
is: SBO:0000247

metaR OAGD3te
name: oagd3 hs transport
reversible: true
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
type: Reaction
reactant: MODEL1310110057#
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_fec1b9ef_b246_47ca_a36b_0f5b4fbb0fd8
is: Q13946
is encoded by: hsa:5150
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
name: PDE7A

metaM pydxn c
is: SBO:0000247
type: Species
is: C00314
is: HMDB00239
has only substance units: false
constant: false
is: CHEBI:16709
boundary condition: false
name: Pyridoxine
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314

metaM CE2916 e
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247
has only substance units: false
type: Species
is: C01936
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C35H51N6O10 CHARGE: -1 INCHI: InChI=1/C35H52N6O10/c1-5-20(4)29(35(50)51)39-31(46)26-9-7-17-41(26)34(49)24(14-15-27(43)44)37-32(47)28(19(2)3)38-30(45)25-8-6-16-40(25)33(48)23(36)18-21-10-12-22(42)13-11-21/h10-13,19-20,23-26,28-29,42H,5-9,14-18,36H2,1-4H3,(H,37,47)(H,38,45)(H,39,46)(H,43,44)(H,50,51)/p-1/t20-,23+,24+,25+,26+,28-,29-/m0/s1 EHMN_ABBREVIATION: CE2916
name: neocasomorphin

metaR FUT14g
reversible: false
kinetic law: MODEL1310110057#
product: MODEL1310110057#
name: Galactoside 2-alpha-L-fucosyltransferase 1
modifier: MODEL1310110057#
is described by: ECO:0000269
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
reactant: MODEL1310110057#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.69

metaM c101crn c
name: decenoyl carnitine
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB13205
notes: FORMULA: C17H31NO4 CHARGE: 0
constant: false
initial amount: NaN

metaR GUAt
reversible: true
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
is: SBO:0000185
name: Guanine transport
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000269
reactant: MODEL1310110057#
modifier: MODEL1310110057#
fast: false
type: Reaction

metaM cdp n
is: CHEBI:58069
boundary condition: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB01546
has only substance units: false
name: CDP(3-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_862382b0_b5c4_4086_a90f_63d13f833714
name: DGAT1
type: Species
boundary condition: true
is: O75907
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8694
initial concentration: NaN
constant: false
has only substance units: false

metaR r1299
type: Reaction
name: Vesicular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110057#
reversible: false
is described by: ECO:0000000
product: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110057#_19bcf3cc_ac5a_41af_a775_5ea324bc585a
constant: false
name: SLC2A6
initial amount: NaN
is encoded by: hsa:11182
is: Q9UGQ3
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN

metaM prostge1 e
type: Species
is: HMDB01442
initial amount: NaN
is: CHEBI:57397
boundary condition: false
has only substance units: false
name: prostaglandin E1(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM pail45p hs m
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:28910
initial concentration: 1.0
name: phosphatidylinositol 4,5-bisphosphate
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
has only substance units: false
boundary condition: false
constant: false

metaR r1147
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110057#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110057#
reactant: MODEL1310110057#

metaM fgam c
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
is: C04376
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
constant: false
is: HMDB01308
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
has only substance units: false
is: CHEBI:58426
initial amount: NaN

metaR G14T3g
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110057#
is: SBO:0000176
product: MODEL1310110057#
type: Reaction
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD

metaR ALAtN1
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
is described by: ECO:0000269
name: Alanine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110057#

metaR r1292
name: Postulated transport reaction
reactant: MODEL1310110057#
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000185

metaR FAOXC201C181x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

metaR B3GNT314g
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
product: MODEL1310110057#
fast: false
reversible: false
is described by: ECO:0000254
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is: SBO:0000176
type: Reaction

metaR 4ABUTtm
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD
name: 4-aminobutanoate mitochondrial transport via diffusion
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110057#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110057#_0ad375e9_b3af_4298_860f_1e92b709a5ca
is encoded by: hsa:2519
constant: false
has only substance units: false
name: FUCA2
initial amount: NaN
initial concentration: NaN
is: Q9BTY2
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_7701262c_d9cf_4f40_87a6_e6cf7559a3c5
is encoded by: hsa:1103
is: D3DX95
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: CHAT

metaM CE2424 m
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB11123
is: CHEBI:28387
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species

metaR r0730
reversible: false
is: SBO:0000176
reactant: MODEL1310110057#
type: Reaction
fast: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211

metaR FORtr
product: MODEL1310110057#
is: SBO:0000185
name: FOR transporter, endoplasmic reticulum
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
is described by: ECO:0000000
type: Reaction

metaM 34dhoxmand m
type: Species
name: 3,4-Dihydroxymandelate
is: CHEBI:27637
has only substance units: false
is: HMDB01866
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110057#_4c5930e4_692c_4bb9_bec2_1a9dc286f26e
initial amount: NaN
is encoded by: hsa:8803
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
is: E5KS60
name: SUCLA2

http://identifiers.org/biomodels.db/MODEL1310110057#_d2e28afa_bcf8_400a_b155_5b9dad432e16
boundary condition: true
is: SBO:0000252
name: SLC2A13
is: Q96QE2
is encoded by: hsa:114134
type: Species
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

metaR ATPH2e
kinetic law: MODEL1310110057#
type: Reaction
is described by: ECO:0000269
name: ATP diphosphohydrolase
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.6
notes: GENE_ASSOCIATION: (954.2) or (954.1) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: false

metaM hpdcacoa m
type: Species
initial concentration: 1.0
is: HMDB06497
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
name: heptadecanoyl coa
constant: false

metaR r1148
reactant: MODEL1310110057#
is: SBO:0000185
kinetic law: MODEL1310110057#
name: Active transport
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110057#

metaM gln L e
name: L-glutamine
is: CHEBI:18050
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: HMDB00641
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_bb84c832_4716_4b62_8bb8_57c3dd2aff42
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
name: NDUFB11
is encoded by: hsa:54539
is: Q9NX14

metaM 3ohdcoa m
initial amount: NaN
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
is: SBO:0000247
is: HMDB06402
has only substance units: false
name: 3-oxopalmitoyl-CoA(4-)
initial concentration: 1.0
constant: false
is: CHEBI:57349
boundary condition: false
type: Species

metaR RE3079X
is version of: http://identifiers.org/ec-code/6.2.1.3
name: RE3079
product: MODEL1310110057#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:11356164 NOTES:IT - fixed proton
modifier: MODEL1310110057#
reversible: true
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
is described by: ECO:0000000

metaM acngalgbside hs g
initial amount: NaN
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
is: CHEBI:16523
is: HMDB03406
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: SBO:0000247
name: sialyl galactosylgloboside
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_7f58fc0e_7f6a_4e6c_be4a_0a6da88a4e28
boundary condition: true
is encoded by: hsa:3032
is: SBO:0000252
is: P55084
name: HADHB
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

metaM hdcea e
is: HMDB03229
is: SBO:0000247
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
name: Hexadecenoate (n-C16:1)
type: Species
is: CHEBI:32372
has only substance units: false

metaR EX but LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Butyrate (n-C4:0) exchange
type: Reaction

metaR r0732
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
product: MODEL1310110057#
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000
reactant: MODEL1310110057#
reversible: false
fast: false
type: Reaction
is: SBO:0000176

metaM leuktrB4 c
has only substance units: false
is: CHEBI:57461
is: HMDB01085
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: leukotriene B4(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
constant: false

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

metaR RE2625C
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110057#
name: RE2625

http://identifiers.org/biomodels.db/MODEL1310110057#_68fc385f_51b7_4191_b297_d7a6cd289cc3
is: Q16850
initial amount: NaN
is encoded by: hsa:1595
type: Species
initial concentration: NaN
name: CYP51A1
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_1f954432_bca7_4589_bfac_7a0fe2950692
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:6555
is: Q12908
name: SLC10A2
type: Species

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

metaR r0483
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
is: SBO:0000176
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
type: Reaction
product: MODEL1310110057#
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
is described by: ECO:0000000

metaR r0731
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
reactant: MODEL1310110057#
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: false
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110057#
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_102dcc06_8d52_4c48_9df3_892b13900806
initial concentration: NaN
boundary condition: true
type: Species
name: DHCR24
constant: false
is: Q15392
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:1718

metaR r2408
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
product: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000185
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

http://identifiers.org/biomodels.db/MODEL1310110057#_56c95d8e_f1b8_443b_8db8_20979f14957b
boundary condition: true
initial amount: NaN
is encoded by: hsa:10026
has only substance units: false
constant: false
type: Species
is: Q92643
is: SBO:0000252
name: PIGK
initial concentration: NaN

metaR UREAt5
type: Reaction
modifier: MODEL1310110057#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:NCD
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: true
reactant: MODEL1310110057#
name: urea, water cotransport
is described by: ECO:0000269

metaM dsmsterol r
initial concentration: 1.0
is: HMDB02719
is: CHEBI:17737
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
name: desmosterol
is: SBO:0000247

metaR FAOXC123C102m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)m
type: Reaction

metaM 3aib e
is: HMDB02166
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: SBO:0000247
is: CHEBI:33094
name: (S)-3-aminoisobutyric acid

metaM gln L c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00641
boundary condition: false
is: CHEBI:18050
constant: false
name: L-glutamine
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067

metaM fru c
boundary condition: false
type: Species
is: HMDB00660
has only substance units: false
name: D-Fructose
constant: false
initial concentration: 1.0
is: C00095
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: CHEBI:15824
initial amount: NaN

metaR DURItn
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
name: deoxyuridine transport in nucleus
product: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
reversible: true

metaR S23T3g
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110057#
fast: false
reversible: false
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.99.6
type: Reaction
reactant: MODEL1310110057#
is described by: ECO:0000000
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)

metaR GLYOX
reversible: false
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
name: hydroxyacylglutathione hydrolase
notes: GENE_ASSOCIATION: (3029.1) or (84264.2) or (84264.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.6 Confidence Level: 4 AUTHORS: PMID:15117945,PMID:8550579 NOTES:IF
is described by: ECO:0000269
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.6
reactant: MODEL1310110057#

metaR r0594
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
reactant: MODEL1310110057#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000176
product: MODEL1310110057#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_7313f359_9581_4e56_8c89_abd3654b8769
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: GAPDHS
has only substance units: false
type: Species
is: O14556
constant: false
initial amount: NaN
is encoded by: hsa:26330

http://identifiers.org/biomodels.db/MODEL1310110057#_9f14fe09_cbc1_42eb_b863_aa344ea2f471
initial amount: NaN
is: Q9NSW9
name: SLC9A5
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:6553

metaR PEt
reversible: true
reactant: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#
is: SBO:0000185
product: MODEL1310110057#
type: Reaction
name: phosphatidylethanolamine transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_e84e77cc_1c83_44df_9398_51d748e468de
constant: false
initial amount: NaN
is: P37268
is encoded by: hsa:2222
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: FDFT1

metaM 5mta e
is: C00170
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17509
initial amount: NaN
type: Species
constant: false
name: 5-Methylthioadenosine
boundary condition: false
has only substance units: false
notes: FORMULA: C11H15N5O3S CHARGE: 0
is: HMDB01173

metaR RE3270C
reactant: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
fast: false
name: RE3270
reversible: true
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:IT - fixed proton
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_fb11fdfe_102a_43e2_a8f1_8e4141df17a4
name: RDH5
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5959
boundary condition: true
type: Species
is: Q92781
has only substance units: false

metaM pail45p hs c
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
constant: false
is: CHEBI:28910
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: phosphatidylinositol 4,5-bisphosphate
type: Species
initial concentration: 1.0

metaM mi13p c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: 1D-myo-Inositol 1,3-bisphosphate
is: CHEBI:18225
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: HMDB06234
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-

metaR PI34P5K
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.68
reactant: MODEL1310110057#
product: MODEL1310110057#
fast: false
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
kinetic law: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110057#

metaR DM atp c
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000134
product: MODEL1310110057#
reversible: false
kinetic law: MODEL1310110057#
name: DM_atp(c)

metaR RE3421R
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
reactant: MODEL1310110057#
name: RE3421
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110057#
product: MODEL1310110057#

metaM fadh2 x
is: HMDB01197
initial amount: NaN
name: FADH2(2-)
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
initial concentration: 1.0
has only substance units: false
is: CHEBI:58307
type: Species

metaM hexdectecoa x
boundary condition: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial amount: NaN
is: HMDB02288
name: 2,4,7,10-hexadecatetraenoylcoa
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial concentration: 1.0

metaM leuktrB4 e
initial concentration: 1.0
has only substance units: false
is: HMDB01085
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
constant: false
is: CHEBI:57461
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
name: leukotriene B4(1-)

metaR r2403
kinetic law: MODEL1310110057#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reactant: MODEL1310110057#
fast: false

metaR r2516
kinetic law: MODEL1310110057#
product: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110057#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_b5583e02_e557_4b65_9080_bac136eef7d8
has only substance units: false
is: SBO:0000252
is: B3KQH0
is encoded by: hsa:55343
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
name: SLC35C1

http://identifiers.org/biomodels.db/MODEL1310110057#_14bd3e8c_30e9_405b_a4aa_2f07e169523b
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
name: _AI926493_1_c
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI926493

metaR RE0935E
name: RE0935
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.2.1.1
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110057#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_6ad32bbc_07bf_4296_89da_b7caca8dc482
initial amount: NaN
is encoded by: hsa:29124
has only substance units: false
constant: false
is: Q9UHV8
boundary condition: true
initial concentration: NaN
name: LGALS13
type: Species
is: SBO:0000252

metaR UGALGTg
is described by: ECO:0000134
is: SBO:0000176
fast: false
reactant: MODEL1310110057#
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (3906.1) and (2683.1) or (8704.2) or (8704.1) SUBSYSTEM: Galactose metabolism EC Number: 2.4.1.22 Confidence Level: 4 AUTHORS: PMID:11419947 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
name: UDPgalactose:D-glucose 4-beta-D-galactosyltransferase, Golgi apparatus

metaM occoa c
is: CHEBI:57386
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: C01944
initial amount: NaN
constant: false
is: HMDB01070
boundary condition: false
name: Octanoyl-CoA (n-C8:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110057#_metaR_EX_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIA glycolipid exchange
type: Reaction

metaR ADNCYC
is version of: http://identifiers.org/ec-code/4.6.1.1
is described by: ECO:0000269
name: adenylate cyclase
modifier: MODEL1310110057#
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110057#_3c05d6ee_876f_4d58_a0ec_d58280974324
is: SBO:0000252
is encoded by: hsa:5298
type: Species
boundary condition: true
is: Q9UBF8
initial concentration: NaN
initial amount: NaN
name: PI4KB
constant: false
has only substance units: false

metaM tetdece1coa c
is: SBO:0000247
type: Species
boundary condition: false
name: tetradecenoylcoa
has only substance units: false
initial amount: NaN
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
initial concentration: 1.0
is: HMDB05066
constant: false

metaR RE1447M
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110057#
type: Reaction
fast: false
name: RE1447
reversible: true
modifier: MODEL1310110057#
is described by: ECO:0000000
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.3.1.41

metaR N3Tg
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.122
modifier: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000176
fast: false
reversible: false
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_b90a2bde_b72f_4c72_9004_f3aab0a602b4
constant: false
is: O14975
has only substance units: false
is encoded by: hsa:11001
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: SLC27A2

http://identifiers.org/biomodels.db/MODEL1310110057#_e768bf62_28ab_4a65_af99_52c54a75c55e
name: PLCB2
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is: Q59F77
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5330

http://identifiers.org/biomodels.db/MODEL1310110057#_07cce3f8_e7c8_4be5_8854_b9b149fd6b55
has part: Q9BQL0
constant: false
type: Species
is: SBO:0000297
is encoded by: hsa:594
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
name: DBT:DLD:BCKDHA:BCKDHB

metaM b2coa m
is: SBO:0000247
boundary condition: false
type: Species
constant: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
has only substance units: false
is: HMDB02009
is: CHEBI:57332
initial amount: NaN
initial concentration: 1.0
name: crotonoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110057#_e0505fd8_cfc7_4f89_ba20_692fcce902ee
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
name: ABCD1
is: SBO:0000252
is: P33897
initial amount: NaN
is encoded by: hsa:215

http://identifiers.org/biomodels.db/MODEL1310110057#_833d80b6_97a7_4ca0_ab7f_f4b75ac24834
name: HK2
is: SBO:0000252
type: Species
is: P52789
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:3099
constant: false

metaR DASCBR
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110057#
reversible: false
type: Reaction
product: MODEL1310110057#
modifier: MODEL1310110057#
fast: false
name: dehydroascorbate reductase
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
is version of: http://identifiers.org/ec-code/1.8.4.1
reactant: MODEL1310110057#

metaR RE1447N
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
fast: false
name: RE1447
kinetic law: MODEL1310110057#
is: SBO:0000176
reactant: MODEL1310110057#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110057#

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaM leu L m
is: HMDB00687
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
type: Species
name: L-leucine
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: CHEBI:15603

metaR RETFA
type: Reaction
is described by: ECO:0000000
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reversible: false
fast: false
is: SBO:0000176
name: retinol acyltransferase

metaM CE5125 x
name: (2S)-pristanoyl-CoA
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5125
is: CHEBI:12947

metaR FAOXTC101TC102m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:1-->C10:2)m
type: Reaction

metaR r2405
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110057#
is: SBO:0000185
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
reactant: MODEL1310110057#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_14991fe2_61c9_4203_ac52_fa81bc58621c
initial amount: NaN
boundary condition: true
is encoded by: hsa:92745
initial concentration: NaN
is: Q8WUX1
name: SLC38A5
constant: false
has only substance units: false
is: SBO:0000252
type: Species

metaR HOXG
modifier: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
kinetic law: MODEL1310110057#
type: Reaction
is described by: ECO:0000134
name: Heme oxygenase 1
fast: false
is version of: http://identifiers.org/ec-code/1.14.99.3

metaR SCPx
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.176
reactant: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
is described by: ECO:0000269
kinetic law: MODEL1310110057#
name: peroxisomal thiolase 2
product: MODEL1310110057#
modifier: MODEL1310110057#
reversible: false

metaR AKGtp
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110057#
reversible: true
reactant: MODEL1310110057#
name: AKG transporter, peroxisome
is: SBO:0000185
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
fast: false

metaR RE0383C
fast: false
modifier: MODEL1310110057#
is: SBO:0000176
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000000
name: RE0383

metaR SEBCOAPET
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

metaR CHLtm
is described by: ECO:0000000
reactant: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
type: Reaction
reversible: true
name: choline transport via diffusion (cytosol to mitochondria)
kinetic law: MODEL1310110057#
fast: false
product: MODEL1310110057#

metaR r0591
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110057#_2f3d6b22_268e_4887_9f0d_d6c037095f21
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaM mpdol L c
has only substance units: false
type: Species
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:18396
constant: false
notes: FORMULA: C1300H2128N20O220P20 CHARGE: -20 INCHI: InChI=1S/C47H82N2O22P2/c1-26(2)13-9-14-27(3)15-10-16-28(4)17-11-18-29(5)19-12-20-30(6)21-22-64-72(60,61)71-73(62,63)70-46-37(49-32(8)54)40(57)43(35(25-52)67-46)68-45-36(48-31(7)53)39(56)44(34(24-51)66-45)69-47-42(59)41(58)38(55)33(23-50)65-47/h13,15,17,19,30,33-47,50-52,55-59H,9-12,14,16,18,20-25H2,1-8H3,(H,48,53)(H,49,54)(H,60,61)(H,62,63)/b27-15+,28-17+,29-19+/t30?,33-,34-,35-,36-,37-,38-,39-,40-,41+,42+,43-,44-,45+,46-,47+/m1/s1
boundary condition: false

metaR RE1135C
is version of: http://identifiers.org/ec-code/3.1.6.2
kinetic law: MODEL1310110057#
name: RE1135
modifier: MODEL1310110057#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:10049998,PMID:1606923 NOTES:
type: Reaction
reactant: MODEL1310110057#
product: MODEL1310110057#
fast: false

metaM 3mop e
name: 3-methyl-2-oxopentanoate
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:28654
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
is: HMDB00491

metaM 3octdece1crn c
notes: FORMULA: C25H47NO5 CHARGE: 0
boundary condition: false
name: 3-hydroxy-octadecenoyl carnitine
is: HMDB13336
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
type: Species

metaR NDPK3n
fast: false
type: Reaction
product: MODEL1310110057#
is: SBO:0000176
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110057#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_089198b6_35cb_46dd_b29e_804562f1aa48
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:83594
name: NUDT12
constant: false
type: Species
is: Q9BQG2
boundary condition: true

metaM s7p c
is: HMDB01068
is: CHEBI:57483
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
name: Sedoheptulose 7-phosphate
is: C05382
constant: false
initial amount: NaN

metaR r0590
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
reversible: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110057#
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_9e2bf5d5_08eb_4459_88aa_0039655621bb
type: Species
initial concentration: NaN
has only substance units: false
is: Q9P0J0
is: SBO:0000252
is encoded by: hsa:51079
initial amount: NaN
name: NDUFA13
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_26548128_555c_478a_ad28_172f6b2cb39e
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P13073
is encoded by: hsa:1327
initial amount: NaN
name: COX4I1
constant: false
type: Species

metaR OAGD3tg
is: SBO:0000185
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reversible: true
product: MODEL1310110057#
name: oagd3 hs intracellular transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110057#_4e22c13a_ce51_46c7_8f87_e7e6887587d4
boundary condition: true
constant: false
is encoded by: hsa:51109
type: Species
initial concentration: NaN
is: B4DDW0
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: RDH11

metaM ksii core2 deg5 l
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 5
constant: false
is: HMDB00143
type: Species
is: CHEBI:12936
has only substance units: false
notes: FORMULA: C50H82N4O38SX CHARGE: -1
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110057#_1ad90934_9105_4100_8627_0da479e1451b
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: _AA177072_1_c
is encoded by: hsa:AA177072
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_45d2aa91_795f_4b7a_988d_0908e67471d0
constant: false
is encoded by: hsa:151531
type: Species
is: SBO:0000252
is: O95045
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: UPP2
boundary condition: true

metaR MANter
name: mannose efflux from endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#
reversible: false

metaM acmanap c
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB01121
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H2,15,16,17)/p-2 HEPATONET_1.0_ABBREVIATION: HC01257 EHMN_ABBREVIATION: C04257
is: SBO:0000247
type: Species
is: CHEBI:58557
name: N-acetyl-D-mannosamine 6-phosphate(2-)
has only substance units: false
initial amount: NaN

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

metaM 3snpyr m
initial amount: NaN
is: CHEBI:1665
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
is: SBO:0000247
has only substance units: false
is: HMDB02332
name: 3-Sulfinopyruvate

http://identifiers.org/biomodels.db/MODEL1310110057#_1fdcab98_1056_4ac9_8ff7_af37088ab0e3
is: O95573
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2181
type: Species
constant: false
name: ACSL3
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM phyt x
type: Species
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
has only substance units: false
initial concentration: 1.0
name: phytanate
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00801
is: CHEBI:37257

metaR ALADGLYexR
is: SBO:0000185
modifier: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
name: D-alanine/glycine reversible exchange
reactant: MODEL1310110057#
reversible: true
type: Reaction
kinetic law: MODEL1310110057#
product: MODEL1310110057#

metaM 4mptnl c
boundary condition: false
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17998
has only substance units: false
is: SBO:0000247
name: 4-methylpentanal
is: HMDB01318
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373

metaR PItx
kinetic law: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
type: Reaction
reversible: true
name: Phosphate transporter, peroxisome
fast: false
is: SBO:0000185
reactant: MODEL1310110057#
is described by: ECO:0000000

metaM 3otdcoa m
constant: false
boundary condition: false
name: 3-Oxotetradecanoyl-CoA
type: Species
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
is: HMDB03935
is: CHEBI:28726
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM eicostetcoa m
name: eicosatetranoyl coenzyme A
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
initial amount: NaN
type: Species
is: C16164
has only substance units: false
is: SBO:0000247
constant: false

metaM bilirub r
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00054
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: CHEBI:57977
initial concentration: 1.0
initial amount: NaN
name: bilirubin(2-)
constant: false
type: Species

metaM maltttr e
constant: false
initial amount: NaN
is: HMDB01296
type: Species
is: C02052
is: http://identifiers.org/pubchem.compound/5141
name: Maltotetraose
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052

metaR S6T14g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000176
kinetic law: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false

metaR r2519
type: Reaction
fast: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
name: Utilized transport

metaM 3octdece1crn e
initial concentration: 1.0
notes: FORMULA: C25H47NO5 CHARGE: 0
name: 3-hydroxy-octadecenoyl carnitine
initial amount: NaN
is: HMDB13336
boundary condition: false
type: Species
constant: false
is: SBO:0000247
has only substance units: false

metaM 3mop c
name: 3-methyl-2-oxopentanoate
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
is: CHEBI:28654
is: HMDB00491
boundary condition: false
type: Species
has only substance units: false

metaM c101crn e
boundary condition: false
notes: FORMULA: C17H31NO4 CHARGE: 0
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB13205
name: decenoyl carnitine
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_6dba4f75_84f8_4ff8_a56a_99914a6ea6b9
name: _22305_1_c
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:22305
is: SBO:0000252
constant: false

metaR EX 3ivcrn
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-isovaleryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_2ba172f0_9705_4e5e_abfb_87a6fc6d7fe5
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:10423
name: CDIPT
has only substance units: false
boundary condition: true
type: Species
is: A8K3L7

metaR RPEc
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
name: ribulose 5-phosphate 3-epimerase
reversible: true
kinetic law: MODEL1310110057#
product: MODEL1310110057#
type: Reaction

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

metaM 3octdectecoa m
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
type: Species
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false
name: 3,6,9,12-octadecatetraenoylcoa

metaR GPDDA1
kinetic law: MODEL1310110057#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.46 Confidence Level: 0 AUTHORS: NOTES:JLR
product: MODEL1310110057#
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
reactant: MODEL1310110057#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_36445cec_8d8f_49f0_bdaf_4dfbf5525798
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1716
name: DGUOK
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: E5KSL6

http://identifiers.org/biomodels.db/MODEL1310110057#_7d0e8064_4d81_4bfe_a100_c9f7e8d66b6b
initial amount: NaN
has part: Q8WYR1
initial concentration: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:23533
name: PIK3R5:PIK3CG
is: SBO:0000297

metaR OROTGLUt
name: OROTGLUt
is described by: ECO:0000134
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110057#
product: MODEL1310110057#
fast: false
reversible: true
is: SBO:0000185
type: Reaction

metaR EX 3ddcrn
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

metaM dcsptn1coa x
is: HMDB06513
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205483
initial amount: NaN
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: C16173
initial concentration: 1.0
constant: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
type: Species
is: SBO:0000247

metaM thm c
type: Species
is: C00378
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:0
is: HMDB00235
boundary condition: false
name: Thiamin
notes: FORMULA: C12H17N4OS CHARGE: 1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_aa07b6f7_c9fd_425d_a4c7_957ffa18bf2a
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
name: NDUFS3
boundary condition: true
is: O75489
is encoded by: hsa:4722
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_39d1acc1_b353_45a3_8096_2026d0dd65b3
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial amount: NaN
name: NDUFB4
initial concentration: NaN
has only substance units: false
is: O95168
is encoded by: hsa:4710

metaM 4mptnl e
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:17998
is: SBO:0000247
initial concentration: 1.0
is: HMDB01318
has only substance units: false
name: 4-methylpentanal
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373

metaM 3aib m
has only substance units: false
name: (S)-3-aminoisobutyric acid
is: HMDB02166
is: CHEBI:33094
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_86acad3b_fd08_4646_b6c4_b9d8ec4f088e
is: P45954
is: SBO:0000252
is encoded by: hsa:36
initial concentration: NaN
constant: false
name: ACADSB
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species

metaM coa x
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: C00010
is: HMDB01423
type: Species
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
name: Coenzyme A
initial concentration: 1.0
is: CHEBI:57287

metaM 3ohdcoa x
is: CHEBI:57349
is: HMDB06402
name: 3-oxopalmitoyl-CoA(4-)
constant: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_24e23682_307b_427d_a005_76c4aac75106
name: NSDHL
is encoded by: hsa:50814
constant: false
initial concentration: NaN
has only substance units: false
is: Q15738
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM fdp c
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB01058
type: Species
name: D-Fructose 1,6-bisphosphate
is: http://identifiers.org/pubchem.compound/3647
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
is: CHEBI:16905
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: C00354

http://identifiers.org/biomodels.db/MODEL1310110057#_056bf47f_8365_470d_8e87_5879b136c20c
name: _AI222095_1_e
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI222095
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_1deae081_c023_4527_9b9f_6c4bd096cd09
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:760
initial amount: NaN
constant: false
is: P00918
initial concentration: NaN
boundary condition: true
name: CA2

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_1cfdeccd_fecc_42e2_9b53_8b1a4271e038
has only substance units: false
is: Q5JPH6
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
name: EARS2
initial concentration: NaN
boundary condition: true
is encoded by: hsa:124454

metaR CO2tm
product: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
fast: false
is described by: ECO:0000000
name: CO2 transport (diffusion), mitochondrial
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110057#

metaR EX 34hpp
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_644ab988_3f57_4682_a481_c5cd8ef57eb6
is: P30837
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
name: ALDH1B1
is encoded by: hsa:219
is: SBO:0000252
type: Species

metaR D LACt2
reversible: true
modifier: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
type: Reaction
reactant: MODEL1310110057#
name: D-lactate transport via proton symport
is: SBO:0000185

metaR HAS1
name: hyaluronan synthase
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110057#
fast: false
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.212
product: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110057#_cd5b1374_0658_4e8c_85d2_e38796e958f8
type: Species
is: SBO:0000252
has only substance units: false
constant: false
name: PPA2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:27068
boundary condition: true

metaM dhdascb e
is: HMDB01264
boundary condition: false
name: dehydroascorbide(1-)
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:58070

metaR C51CPT1
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tiglylcarnitine
type: Reaction

metaR C181CRNt
name: C181 transport into the mitochondria
is: SBO:0000185
type: Reaction
product: MODEL1310110057#
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000000
reversible: false
fast: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV

metaR LCADi
modifier: MODEL1310110057#
name: lactaldehyde dehydrogenase
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.2.1.36
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
is: SBO:0000176
is described by: ECO:0000304
reactant: MODEL1310110057#
product: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR DM dgpi prot hs r
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dgpi prot hs(r)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_cfec3753_69cf_4df1_af92_c6c91a8f8fd8
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: O43315
constant: false
type: Species
name: AQP9
is encoded by: hsa:366

metaM ksii core4 pre4 g
is: HMDB00175
notes: FORMULA: C61H99N5O43X CHARGE: -1
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 4
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58053
is: SBO:0000247
boundary condition: false
constant: false
is: C00130
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_69bb8e83_276e_41e6_927e_c6117dd9603d
is: SBO:0000252
type: Species
constant: false
is: O60503
is encoded by: hsa:115
initial amount: NaN
name: ADCY9
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR r1549
reactant: MODEL1310110057#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110057#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000

metaR TYRTA
kinetic law: MODEL1310110057#
name: tyrosine transaminase
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110057#
reversible: true
type: Reaction
product: MODEL1310110057#
fast: false
reactant: MODEL1310110057#

metaM orn m
boundary condition: false
constant: false
type: Species
is: CHEBI:46912
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: SBO:0000247
is: C01602
initial amount: NaN
is: HMDB00214
has only substance units: false
initial concentration: 1.0
name: Ornithine

metaR r0915
is: SBO:0000185
type: Reaction
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reversible: true
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR AG13T6g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110057#
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000176
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
fast: false

metaM ru5p D c
initial concentration: 1.0
is: CHEBI:58121
constant: false
is: SBO:0000247
name: D-ribulose 5-phosphate(2-)
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
has only substance units: false
is: HMDB00618
boundary condition: false
initial amount: NaN
type: Species

metaR PI345P5P
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.1.3.56
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.1.3.86
reversible: false
reactant: MODEL1310110057#
is: SBO:0000176
fast: false
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.1.3.36
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_c9664484_9566_467e_8f45_53b614a75efb
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
name: NANS
is encoded by: hsa:54187
initial concentration: NaN
is: Q9NR45
has only substance units: false

metaM pac c
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: phenylacetate
is: HMDB00209
is: SBO:0000247
boundary condition: false
is: CHEBI:18401
type: Species

metaM dhdascb c
boundary condition: false
name: dehydroascorbide(1-)
is: CHEBI:58070
type: Species
is: HMDB01264
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false

metaM CE2917 e
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: apelin-13
is: C01936
initial amount: NaN
notes: FORMULA: C69H114N23O16S CHARGE: 3 INCHI: InChI=1/C69H111N23O16S/c1-39(2)32-47(86-58(98)44(17-9-26-78-68(73)74)83-63(103)52-20-12-29-91(52)65(105)45(18-10-27-79-69(75)76)84-56(96)42(71)22-23-54(72)94)59(99)89-50(37-93)61(101)87-48(34-41-35-77-38-81-41)60(100)82-43(16-7-8-25-70)57(97)80-36-55(95)90-28-11-19-51(90)62(102)85-46(24-31-109-3)66(106)92-30-13-21-53(92)64(104)88-49(67(107)108)33-40-14-5-4-6-15-40/h4-6,14-15,35,38-39,42-53,93H,7-13,16-34,36-37,70-71H2,1-3H3,(H2,72,94)(H,77,81)(H,80,97)(H,82,100)(H,83,103)(H,84,96)(H,85,102)(H,86,98)(H,87,101)(H,88,104)(H,89,99)(H,107,108)(H4,73,74,78)(H4,75,76,79)/p+3/t42-,43-,44-,45+,46-,47+,48+,49+,50-,51+,52+,53-/m1/s1 EHMN_ABBREVIATION: CE2917

metaM homoval m
boundary condition: false
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:545959
has only substance units: false
name: Homovanillate
is: HMDB00118

metaR r1548
type: Reaction
reactant: MODEL1310110057#
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110057#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR EX prgstrn LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Progesterone exchange
type: Reaction

metaM 3octpencoa m
is: http://identifiers.org/pubchem.compound/5280355
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
name: 3,6,9,12,15-octadecapentenoylcoa
is: SBO:0000247

metaR DHAAt1r
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
is described by: ECO:0000269
reversible: true
name: dehydroascorbate transport (uniport)
type: Reaction
product: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
is: SBO:0000185
modifier: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_9b6b9ff4_967a_40b7_8b22_1556275d1221
has only substance units: false
name: ACE
initial concentration: NaN
is: B4DKH4
is encoded by: hsa:1636
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species

metaR FAEL204
product: MODEL1310110057#
reactant: MODEL1310110057#
reversible: false
kinetic law: MODEL1310110057#
type: Reaction
name: fatty-acyl-CoA elongation (n-C20:4CoA)
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
modifier: MODEL1310110057#

metaM HC02204 c
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:27624
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
name: prostaglandin-b1

metaR FAOXTC142TC122m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C14:2-->C12:2)m
type: Reaction

metaR RE2974C
modifier: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
fast: false
is: SBO:0000176
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.68
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.1.149
is described by: ECO:0000000
name: RE2974

metaM ribflv c
is: C00255
boundary condition: false
is: CHEBI:3554
initial amount: NaN
name: Riboflavin
is: SBO:0000247
notes: FORMULA: C17H20N4O6 CHARGE: 0
initial concentration: 1.0
type: Species
constant: false
is: HMDB00244
has only substance units: false

metaR r0051
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
type: Reaction
reversible: true
modifier: MODEL1310110057#
reactant: MODEL1310110057#
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
fast: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.5
product: MODEL1310110057#
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_b511b010_42b8_4a7e_87a1_1268978f8982
is: P47895
constant: false
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:220
initial amount: NaN
initial concentration: NaN
name: ALDH1A3

metaR HAS2
kinetic law: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.212
reversible: false
name: hyaluronan synthase
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
fast: false
product: MODEL1310110057#
type: Reaction

metaM amp r
is: CHEBI:456215
type: Species
is: C00020
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial amount: NaN
is: SBO:0000247
is: HMDB00045
name: AMP
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_9d0e60d8_07b8_48d0_9061_30b8f110da08
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: PYCR1
is: A6NFM2
is encoded by: hsa:5831

http://identifiers.org/biomodels.db/MODEL1310110057#_77deb790_0b7f_4b6b_824f_fc4b268527ea
is: Q8N0X4
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:171425
initial concentration: NaN
name: CLYBL
type: Species

metaR r1547
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110057#
kinetic law: MODEL1310110057#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110057#

metaR r0917
reactant: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
reversible: true
is: SBO:0000185
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

http://identifiers.org/biomodels.db/MODEL1310110057#_68b9c68e_ce6b_4578_a814_865d1a207889
boundary condition: true
is encoded by: hsa:203
is: SBO:0000252
initial concentration: NaN
is: P00568
type: Species
constant: false
initial amount: NaN
name: AK1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_7645182c_1000_45f4_b367_65d725d22898
is: SBO:0000252
initial concentration: NaN
name: AGA
boundary condition: true
is: P20933
initial amount: NaN
is encoded by: hsa:175
constant: false
has only substance units: false
type: Species

metaM g6p r
name: D-Glucose 6-phosphate
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB01401
is: C00092
is: CHEBI:61548
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
boundary condition: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_ad022bf8_cc84_422f_8139_538c33ea194b
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is: P23786
is encoded by: hsa:1376
name: CPT2

http://identifiers.org/biomodels.db/MODEL1310110057#_d0f48843_478d_4fb1_9578_3ad585c1db75
is encoded by: hsa:8394
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: PIP5K1A
boundary condition: true
has only substance units: false
type: Species
constant: false
is: Q99755

metaR GULLACter
reversible: false
reactant: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES:NCD
kinetic law: MODEL1310110057#
is: SBO:0000185
product: MODEL1310110057#
type: Reaction
is described by: ECO:0000000
name: gulonolactone endoplasmic reticular transport

http://identifiers.org/biomodels.db/MODEL1310110057#_80b26982_bfc6_4516_8e5c_256075c1be54
initial concentration: NaN
is: SBO:0000252
name: NDUFA10
is: O95299
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:4705
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_ce515780_df4f_47d0_aa10_9183ef9fbec9
has only substance units: false
type: Species
is: O94777
initial amount: NaN
is encoded by: hsa:8818
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: DPM2

http://identifiers.org/biomodels.db/MODEL1310110057#_5ba6d11d_365c_4846_80f2_63e1bc5b2fae
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is: P04062
is encoded by: hsa:2629
name: GBA
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_52fd012a_2e87_49b2_9272_f4b5674921ee
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3421
is: SBO:0000252
type: Species
constant: false
name: IDH3G
has only substance units: false
boundary condition: true
is: P51553

http://identifiers.org/biomodels.db/MODEL1310110057#_9b7781e2_594d_447f_8b2b_177f55a87a87
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
name: _AF080579_1_c
initial concentration: NaN
constant: false
is encoded by: hsa:AF080579
is: SBO:0000252

metaM amp m
initial concentration: 1.0
type: Species
has only substance units: false
name: AMP(2-)
initial amount: NaN
boundary condition: false
is: HMDB00045
constant: false
is: SBO:0000247
is: CHEBI:456215
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020

metaR B3GNT33g
fast: false
is: SBO:0000176
kinetic law: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110057#
modifier: MODEL1310110057#
reversible: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
type: Reaction
is described by: ECO:0000269

metaM c226crn m
has only substance units: false
type: Species
is: HMDB06510
initial concentration: 1.0
name: cervonyl carnitine
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/127055
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
constant: false
boundary condition: false

metaR RE1531M
name: RE1531
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110057#
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110057#
product: MODEL1310110057#

metaR FBP
is version of: http://identifiers.org/ec-code/3.1.3.11
product: MODEL1310110057#
fast: false
name: fructose-bisphosphatase
is: SBO:0000176
notes: GENE_ASSOCIATION: (2203.1) or (8789.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.11 Confidence Level: 0 AUTHORS: PMID:9678974 NOTES:SMP
modifier: MODEL1310110057#
reversible: false
type: Reaction
reactant: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_cd20aaad_56f0_4ea4_b0b3_f6a3b2b1f93b
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:84264
boundary condition: true
is: Q6PII5
name: HAGHL
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_7b6d86b7_5349_4bd4_859e_da74a09bd82c
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5289
constant: false
is: Q8NEB9
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: PIK3C3

metaR PVD3
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000134
name: Previtamin D3 formation
product: MODEL1310110057#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110057#_ecc9b31d_c694_49a0_881f_1774d337c401
initial concentration: NaN
is: SBO:0000252
type: Species
is: F6SH78
is encoded by: hsa:60481
has only substance units: false
name: ELOVL5
initial amount: NaN
boundary condition: true
constant: false

metaM ksi e
is: CHEBI:17268
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
initial concentration: 1.0
is: HMDB00211
type: Species
initial amount: NaN
has only substance units: false
name: keratan sulfate I
is: SBO:0000247
constant: false
boundary condition: false

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaM pan4p c
initial amount: NaN
is: HMDB01416
has only substance units: false
constant: false
name: Pantetheine 4'-phosphate
is: CHEBI:47942
initial concentration: 1.0
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: C01134
is: SBO:0000247
boundary condition: false
type: Species

metaM ribflv e
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: Riboflavin
is: C00255
initial amount: NaN
constant: false
is: CHEBI:3554
has only substance units: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
type: Species
is: HMDB00244

http://identifiers.org/biomodels.db/MODEL1310110057#_7af278ae_7ffe_4c83_b1c6_3ecb5683a51c
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: _H45672_1_m
is encoded by: hsa:H45672
initial concentration: NaN

metaR r0911
reversible: true
type: Reaction
fast: false
product: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
kinetic law: MODEL1310110057#
name: Facilitated diffusion
reactant: MODEL1310110057#

metaM leu L e
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00687
name: L-leucine
is: CHEBI:15603
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123

metaM CE5132 c
constant: false
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:57923
initial amount: NaN
type: Species
is: SBO:0000247

metaR C80CPT1
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of octanoylcarnitine
type: Reaction

metaR r0801
reversible: true
product: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
fast: false
kinetic law: MODEL1310110057#
is described by: ECO:0000000
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1

http://identifiers.org/biomodels.db/MODEL1310110057#_84be1dc8_773c_4856_94f5_7d646aa0339c
has part: Q6IBB3
is encoded by: hsa:10632
is encoded by: hsa:516
initial concentration: NaN
is encoded by: hsa:515
is encoded by: hsa:521
is encoded by: hsa:9551
has part: P05496
is encoded by: hsa:4905
has only substance units: false
is encoded by: hsa:10476
has part: Q08ET0
boundary condition: true
initial amount: NaN
has part: P46459
type: Species
name: ATP5H:ATP5L:NSF:ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
has part: A0PJH2
has part: O75964
constant: false
is encoded by: hsa:522
has part: P56385
is: SBO:0000297

metaR UGLT
product: MODEL1310110057#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110057#
name: UDPglucose--hexose-1-phosphate uridylyltransferase
fast: false
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
type: Reaction
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.7.12
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110057#_d8cb952f_8b7d_4f10_bba7_c00a2642a143
initial concentration: NaN
is encoded by: hsa:T83654
type: Species
initial amount: NaN
name: _T83654_1_e
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_e92ce7ef_7938_471b_8fc3_d422dc08b9d1
has only substance units: false
constant: false
is encoded by: hsa:788
is: O43772
boundary condition: true
name: SLC25A20
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN

metaM urea m
boundary condition: false
initial amount: NaN
is: C00086
name: Urea
is: SBO:0000247
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
is: CHEBI:16199
is: HMDB00294
constant: false
type: Species
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_d08db1b8_b35f_4a84_95ae_e5a55562627a
name: SLC22A2
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6582
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: O15244

metaM CE5586 c
type: Species
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:58732
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR r0913
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
product: MODEL1310110057#
is described by: ECO:0000000
reactant: MODEL1310110057#
type: Reaction

metaR TALA
modifier: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
fast: false
name: transaldolase
is described by: ECO:0000000
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.2.1.2

metaM ksi pre4 g
is: HMDB00175
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 4
constant: false
type: Species
is: C00130
has only substance units: false
boundary condition: false
is: CHEBI:58053
notes: FORMULA: C101H165N7O72X CHARGE: -1

metaR CYOOm3
name: cytochrome c oxidase, mitochondrial Complex IV
reversible: false
is: SBO:0000185
fast: false
modifier: MODEL1310110057#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.9.3.1
type: Reaction
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
product: MODEL1310110057#
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_343d832c_a33d_4267_9af4_ecff5ab16512
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:6817
type: Species
name: SULT1A1
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_dcf8ef7f_a2e5_449e_9022_9fd03dbbfde0
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:7166
boundary condition: true
initial amount: NaN
name: TPH1
is: P17752
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_9a7facd9_7204_40ef_90ee_7f20b60a52d0
initial concentration: NaN
constant: false
name: PLCB1
is encoded by: hsa:23236
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN

metaR GALASE9ly
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110057#
is described by: ECO:0000000
fast: false
reversible: false
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_dcf66b0c_af3c_43b1_91f6_151f0908ecf0
initial amount: NaN
boundary condition: true
name: CHST5
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:23563
type: Species
constant: false

metaM cit m
boundary condition: false
is: SBO:0000247
constant: false
is: C00158
initial concentration: 1.0
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
name: Citrate
type: Species
is: CHEBI:16947
is: HMDB00094
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_4e710c62_9dc6_4072_8b8e_9d21050da8db
constant: false
type: Species
initial amount: NaN
name: LDHAL6B
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q9BYZ2
is: SBO:0000252
is encoded by: hsa:92483

metaM dmhptcrn m
name: 2,6 dimethylheptanoyl carnitine
initial amount: NaN
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
is: HMDB06320
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_721eac6d_3b6e_4a91_a6d6_fd2601f347e8
has only substance units: false
name: SLC25A26
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:115286
initial concentration: NaN

metaR EX CE4722 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-casomorphin (1-6) exchange
type: Reaction

metaR R group phosphotase 1
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
name: R group phosphotase 1

metaM adrnl c
notes: FORMULA: C9H14NO3 CHARGE: 1 INCHI: InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3 EHMN_ABBREVIATION: C00788
initial concentration: 1.0
has only substance units: false
is: CHEBI:33568
boundary condition: false
initial amount: NaN
type: Species
constant: false
name: Adrenaline
is: SBO:0000247
is: HMDB00068

metaR THYMDtm
fast: false
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:TDV
is: SBO:0000185
name: thymd transport
product: MODEL1310110057#
reactant: MODEL1310110057#
modifier: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_571ea19d_2f0d_4ebc_a9ff_34f8a041cd25
is: Q8IWW8
initial concentration: NaN
name: ADHFE1
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:137872
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_5d7f7c53_6fab_4acd_8d44_6007c467e74e
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:H53099
name: _H53099_1_m
initial concentration: NaN
constant: false

metaM amp x
is: SBO:0000247
constant: false
name: AMP
has only substance units: false
initial concentration: 1.0
is: C00020
is: HMDB00045
is: CHEBI:456215
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020

metaR RE1903R
is: SBO:0000176
product: MODEL1310110057#
reversible: true
reactant: MODEL1310110057#
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110057#
name: RE1903
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110057#_668d0d79_bb61_4920_aeb0_f21f3a503cc3
is: Q53HM1
type: Species
is encoded by: hsa:54963
initial amount: NaN
initial concentration: NaN
name: UCKL1
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false

metaM orn e
is: CHEBI:0
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB00214
type: Species
is: C01602
name: Ornithine
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H13N2O2 CHARGE: 1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_06d64d20_f33b_453a_85ae_a7ef63131028
is: SBO:0000252
is: Q16706
boundary condition: true
name: MAN2A1
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:4124
constant: false
has only substance units: false

metaR FUMSO4tm
reactant: MODEL1310110057#
reversible: true
fast: false
is described by: ECO:0000269
name: Fumarate:sulfate antiport, mitochondrial
is: SBO:0000185
product: MODEL1310110057#
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
type: Reaction

metaR CITtam
name: citrate transport, mitochondrial
product: MODEL1310110057#
is described by: ECO:0000269
reversible: true
fast: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_3031f822_27c6_4ba5_81ef_cfea0a916f64
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:217
name: ALDH2
is: P05091
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species

metaR RE2814R
type: Reaction
kinetic law: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
reversible: true
name: RE2814
fast: false
is described by: ECO:0000000
product: MODEL1310110057#
reactant: MODEL1310110057#

metaM HC02206 e
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
constant: false
is: CHEBI:57399
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
name: prostaglandin C1(1-)

metaM 3pg m
is: HMDB00807
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
has only substance units: false
type: Species
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
constant: false
is: CHEBI:58272
initial amount: NaN
boundary condition: false

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_a27c3b3b_75af_471e_9d48_0e1c442c0c68
boundary condition: true
is encoded by: hsa:9197
initial amount: NaN
is: O00400
initial concentration: NaN
name: SLC33A1
constant: false
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_b1648880_c7d4_4c06_9431_ada2c8163339
constant: false
type: Species
has only substance units: false
name: CA12
initial concentration: NaN
is encoded by: hsa:771
is: O43570
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR C161OHc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecenoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_365506bf_01f3_46ec_98d0_80b43aa60eec
name: NDUFB7
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:4713
is: P17568
constant: false
has only substance units: false

metaR UAGALDP
reactant: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000176
name: UDP-N-acetylgalactosamine diphosphorylase
reversible: false
type: Reaction

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR FBA
is version of: http://identifiers.org/ec-code/4.1.2.13
product: MODEL1310110057#
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
name: fructose-bisphosphate aldolase
modifier: MODEL1310110057#
reversible: true
fast: false
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_374bb7b7_3850_44ce_b135_579b839f8fbc
is encoded by: hsa:11001
type: Species
boundary condition: true
initial concentration: NaN
is: O14975
initial amount: NaN
name: SLC27A2
has only substance units: false
is: SBO:0000252
constant: false

metaR RE3003M
fast: false
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
modifier: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.3.8
is described by: ECO:0000000
reversible: true
name: RE3003

metaR r1540
is described by: ECO:0000000
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110057#
reversible: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
type: Reaction
kinetic law: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is: SBO:0000185

metaM grdp x
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: geranyl diphosphate(3-)
constant: false
initial amount: NaN
has only substance units: false
is: HMDB01285
is: CHEBI:58057

http://identifiers.org/biomodels.db/MODEL1310110057#_c5cfe794_ab24_416f_8985_5d1a680d608b
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: _AGPAT7_1_c
is encoded by: hsa:AGPAT7
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_1c6d6367_7dfc_4e76_a524_fc98010a59a2
is encoded by: hsa:7372
constant: false
boundary condition: true
initial concentration: NaN
is: A8K5J1
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: UMPS

metaR PYNP2r
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
is described by: ECO:0000269
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
product: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
reversible: true
name: pyrimidine-nucleoside phosphorylase (uracil)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.3
type: Reaction

metaR RE1520M
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
reversible: true
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110057#
modifier: MODEL1310110057#
name: RE1520

http://identifiers.org/biomodels.db/MODEL1310110057#_7c4c24f8_7542_482c_847c_dc87ab90e7c6
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3162
type: Species
is: Q6FH11
is: SBO:0000252
name: HMOX1
boundary condition: true
constant: false

metaM leu L c
initial amount: NaN
name: L-leucine
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
constant: false
is: CHEBI:15603
boundary condition: false
is: HMDB00687

http://identifiers.org/biomodels.db/MODEL1310110057#_92ae708f_ba5c_479e_9278_671bdb88104e
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:22934
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: P49247
name: RPIA

metaM HC02206 c
is: CHEBI:57399
has only substance units: false
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: prostaglandin C1(1-)
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_cbc88ef4_d103_4180_ae36_4e06f5e3df86
boundary condition: true
has only substance units: false
is encoded by: hsa:39
constant: false
initial concentration: NaN
type: Species
name: ACAT2
is: SBO:0000252
is: Q9BWD1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_9f6444f9_53ce_421e_9448_06d0aa70f192
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: CDIPT
initial concentration: NaN
type: Species
is encoded by: hsa:10423
boundary condition: true
is: O14735

http://identifiers.org/biomodels.db/MODEL1310110057#_cd3249a3_fb01_4a66_83d3_7e203e210f58
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: CYP1A2
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:1544
is: P05177

metaR OCDEAFABP1tc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of octadecenoyl coA into the enterocytes
type: Reaction

metaM pail3p hs c
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
constant: false
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
is: CHEBI:58088
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR r0747
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110057#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
is: SBO:0000176
modifier: MODEL1310110057#

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaM mmcoa R m
name: (R)-methylmalonyl-CoA(5-)
is: HMDB01269
is: CHEBI:57326
has only substance units: false
boundary condition: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR XYLt
kinetic law: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
name: D-xylose reversible transport
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
modifier: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110057#_cde91a57_45c9_401d_a09d_8830a301b2a2
has only substance units: false
is: P49748
name: ACADVL
boundary condition: true
is encoded by: hsa:37
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
initial amount: NaN

metaR PYDXPP
reactant: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
product: MODEL1310110057#
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (57026.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:14522954,PMID:6380540 NOTES:
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/3.1.3.3
modifier: MODEL1310110057#
name: Pyridoxal 5-phosphate phosphatase

metaR r1546
type: Reaction
kinetic law: MODEL1310110057#
is: SBO:0000185
product: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaR TSTSTERONESULT
fast: false
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
product: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
name: testosterone sulfotransferase
notes: GENE_ASSOCIATION: (6822.1) or (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.8.2.14

http://identifiers.org/biomodels.db/MODEL1310110057#_66ac678e_0b16_4246_b167_10bdd6a06a9b
boundary condition: true
has only substance units: false
constant: false
is: Q6UVY6
initial concentration: NaN
initial amount: NaN
name: MOXD1
is encoded by: hsa:26002
type: Species
is: SBO:0000252

metaM nrpphr e
constant: false
has only substance units: false
is: CHEBI:33569
is: HMDB00216
is: SBO:0000247
initial amount: NaN
name: Norepinephrine
boundary condition: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_28e1ec65_fe2c_42dc_aed8_42f5ee8912aa
is: SBO:0000252
name: PANK2
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:80025
initial concentration: NaN

metaR CYTDn
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.5.4.5
reversible: false
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:
kinetic law: MODEL1310110057#
type: Reaction
is: SBO:0000176
name: cytidine deaminase, nuclear
is described by: ECO:0000254
fast: false
product: MODEL1310110057#

metaM hpdcacoa c
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
name: heptadecanoyl coa
type: Species
is: HMDB06497
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false

metaM tetdec2coa c
has only substance units: false
constant: false
boundary condition: false
name: tetradecadienoylcoa
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
is: HMDB02014
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_a1fc601a_5f79_43b5_805b_d7675ee6e5d0
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
name: _22305_2_c
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:22305

metaM val L e
boundary condition: false
is: SBO:0000247
is: HMDB00883
type: Species
has only substance units: false
constant: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial concentration: 1.0
is: CHEBI:16414
name: L-valine
initial amount: NaN

metaR B3GNT311g
is: SBO:0000176
reactant: MODEL1310110057#
fast: false
is described by: ECO:0000254
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
product: MODEL1310110057#

metaR EX CE2917 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: apelin-13 exchange
type: Reaction

metaM urea c
is: HMDB00294
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:16199
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: C00086
name: Urea

http://identifiers.org/biomodels.db/MODEL1310110057#_12738130_4d64_44e9_b7c2_929c5f8abc1a
is: Q5SPY7
type: Species
name: ENTPD2
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:954
constant: false
has only substance units: false

metaR C18OHc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecanoylcarnitine
type: Reaction

metaR RTOTALt
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
name: RTOTAL transport
reversible: true
kinetic law: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110057#
fast: false

metaM g6p c
name: D-Glucose 6-phosphate
has only substance units: false
is: HMDB01401
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
constant: false
initial amount: NaN
is: CHEBI:61548
initial concentration: 1.0
is: C00092
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_46281b6a_e4f2_4362_9df5_56d8c398ec79
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: Q86SK9
is: SBO:0000252
is encoded by: hsa:79966
has only substance units: false
initial amount: NaN
name: SCD5

http://identifiers.org/biomodels.db/MODEL1310110057#_c461327d_a2a7_44d9_b5cc_f5253c0ecee0
name: FOLR1
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:2348
is: SBO:0000252

metaR r0463
reversible: true
fast: false
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
product: MODEL1310110057#
is described by: ECO:0000000
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction
is: SBO:0000176

metaM tmndnc c
has only substance units: false
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/446284
name: timnodonic acid C20:5, n-3
type: Species
initial amount: NaN
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: HMDB01999
initial concentration: 1.0
constant: false

metaM HC02204 e
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
initial concentration: 1.0
name: prostaglandin-b1
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:27624
type: Species

metaR HPDCAt
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
name: fatty acid transport via diffusion
kinetic law: MODEL1310110057#

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_3aa6fe15_8ab8_4850_a164_5c557873d410
name: ATP5J2
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q6IBB3
is encoded by: hsa:9551

http://identifiers.org/biomodels.db/MODEL1310110057#_eb8c2c66_a79e_41b7_ad12_a948caa85f39
is encoded by: hsa:10637
type: Species
initial concentration: NaN
boundary condition: true
is: O75610
name: LEFTY1
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaR MG2er
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
is described by: ECO:0000000
product: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
fast: false
kinetic law: MODEL1310110057#
type: Reaction
is: SBO:0000176
reversible: false

metaR FAOXC102C81m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

metaR ARABR
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.21
name: arabinose reductase
is described by: ECO:0000269
reactant: MODEL1310110057#
reversible: false
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.2
kinetic law: MODEL1310110057#
is: SBO:0000176
modifier: MODEL1310110057#
type: Reaction
product: MODEL1310110057#

metaR r0809
type: Reaction
modifier: MODEL1310110057#
fast: false
reversible: true
name: Facilitated diffusion
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110057#
product: MODEL1310110057#

metaM pi x
initial concentration: 1.0
initial amount: NaN
name: hydrogenphosphate
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
is: SBO:0000247
is: HMDB00973
is: CHEBI:43474

metaR r1544
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110057#
type: Reaction
reversible: true
kinetic law: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110057#

metaM nrpphr c
has only substance units: false
constant: false
is: CHEBI:33569
name: Norepinephrine
is: HMDB00216
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
boundary condition: false
initial concentration: 1.0
type: Species

metaM val L c
is: SBO:0000247
has only substance units: false
is: HMDB00883
type: Species
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
constant: false
name: L-valine
boundary condition: false
initial concentration: 1.0
is: CHEBI:16414

metaR r0464
kinetic law: MODEL1310110057#
is described by: ECO:0000000
fast: false
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
product: MODEL1310110057#
type: Reaction
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
reactant: MODEL1310110057#

metaM 3aib c
has only substance units: false
boundary condition: false
constant: false
is: HMDB02166
initial concentration: 1.0
is: CHEBI:33094
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
type: Species
is: SBO:0000247
initial amount: NaN
name: (S)-3-aminoisobutyric acid

metaR SBCOAACOTx
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of suberyl coa for release into cytosol
type: Reaction

metaM CE4722 e
name: beta-casomorphin (1-6)
initial amount: NaN
notes: FORMULA: C38H49N6O10 CHARGE: -1 INCHI: InChI=1/C38H50N6O10/c1-22(2)32(35(50)40-27(16-17-31(46)47)37(52)44-19-7-11-30(44)38(53)54)42-33(48)28(21-23-8-4-3-5-9-23)41-34(49)29-10-6-18-43(29)36(51)26(39)20-24-12-14-25(45)15-13-24/h3-5,8-9,12-15,22,26-30,32,45H,6-7,10-11,16-21,39H2,1-2H3,(H,40,50)(H,41,49)(H,42,48)(H,46,47)(H,53,54)/p-1/t26-,27+,28+,29-,30+,32-/m1/s1 EHMN_ABBREVIATION: CE4722
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: C01936
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false

metaM urea e
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
name: Urea
has only substance units: false
is: CHEBI:16199
is: HMDB00294
is: C00086
initial concentration: 1.0
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086

metaM orn c
is: C01602
constant: false
name: Ornithine
has only substance units: false
type: Species
is: CHEBI:0
is: SBO:0000247
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: HMDB00214
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR RIBt
type: Reaction
reversible: true
name: ribose transport via diffusion
kinetic law: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110057#

metaR LEUGLYPEPT1tc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR 3MOPte
is described by: ECO:0000134
name: Transport of 3-methyl-2-oxopentanoate
product: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_26755a1d_edd8_4d19_a84b_c82f98d93141
boundary condition: true
constant: false
is encoded by: hsa:10317
type: Species
is: Q9Y2C3
initial amount: NaN
name: B3GALT5
is: SBO:0000252
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_d2d126a8_e51a_42c4_997c_9ec7282f1fe0
type: Species
has only substance units: false
is: Q13454
is encoded by: hsa:7991
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: TUSC3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_a77ab8ef_0c69_4275_b917_a3ee72c84fc8
name: PGM3
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:5238
is: B4DX94

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaR G14T17g
kinetic law: MODEL1310110057#
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110057#
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false

metaR r0055
fast: false
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110057#
product: MODEL1310110057#
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
reversible: true
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
is version of: http://identifiers.org/ec-code/2.4.2.8
is version of: http://identifiers.org/ec-code/2.4.2.7
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_a1306597_7c4e_44c5_a6f9_261365348c5e
is: SBO:0000252
name: PPA1
is encoded by: hsa:5464
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
is: Q15181

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaM tmndnc e
constant: false
initial amount: NaN
is: HMDB01999
is: SBO:0000247
name: timnodonic acid C20:5, n-3
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/446284
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
boundary condition: false
type: Species
has only substance units: false

metaM m8mpdol L r
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C1780H2928N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1 EHMN_ABBREVIATION: C05868
initial amount: NaN
is: SBO:0000247
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
is: CHEBI:59093

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_2c275c1f_4ed8_4626_a12e_34211487068c
type: Species
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: ACLY
is: SBO:0000252
boundary condition: true
is encoded by: hsa:47

metaR HACD9m
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
fast: false
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
is described by: ECO:0000134
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR MAOX
name: Methylamine oxidase
fast: false
is described by: ECO:0000304
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:11136547,PMID:14715500,PMID:9131641 NOTES:SAB
modifier: MODEL1310110057#
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.21
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.4.3.22

metaR METLEUex
kinetic law: MODEL1310110057#
type: Reaction
fast: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (6520.1 and 8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
reversible: false
product: MODEL1310110057#
is: SBO:0000185
modifier: MODEL1310110057#
name: Methionine/Leucine exchange (Met in)
is described by: ECO:0000269

metaM hxan c
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
constant: false
name: Hypoxanthine
is: C00262
is: HMDB00157
boundary condition: false
is: CHEBI:17368
has only substance units: false
initial concentration: 1.0

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaM ppi x
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00250
has only substance units: false
is: CHEBI:33019
initial amount: NaN
name: Diphosphate
is: C00013
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
boundary condition: false
constant: false

metaR r2526
kinetic law: MODEL1310110057#
reversible: true
product: MODEL1310110057#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
fast: false
is described by: ECO:0000000

metaR r0744
reactant: MODEL1310110057#
is: SBO:0000176
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
reversible: false
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110057#

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaR URIDK2m
is described by: ECO:0000134
kinetic law: MODEL1310110057#
name: uridylate kinase (dUMP), mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
reversible: true
fast: false
reactant: MODEL1310110057#
is: SBO:0000176
product: MODEL1310110057#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_3bc5c1bd_4aa3_4e2e_ae93_bf5499dd472f
constant: false
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6818
initial concentration: NaN
initial amount: NaN
is: Q1ET61
name: SULT1A3

metaR G14T4g
product: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
kinetic law: MODEL1310110057#
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
is described by: ECO:0000000

metaR F6Tg
type: Reaction
modifier: MODEL1310110057#
reactant: MODEL1310110057#
reversible: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.68
is described by: ECO:0000000
name: glycoprotein 6-alpha-L-fucosyltransferase

http://identifiers.org/biomodels.db/MODEL1310110057#_922e24a2_dbab_4b6a_91a1_3716bbdbbe73
boundary condition: true
has only substance units: false
is: Q9Y619
is: SBO:0000252
is encoded by: hsa:10166
name: SLC25A15
type: Species
initial concentration: NaN
constant: false
initial amount: NaN

metaR NDPK10n
modifier: MODEL1310110057#
fast: false
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
reversible: true
is: SBO:0000176
type: Reaction
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110057#

metaR DLNLCGt
reversible: true
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
name: fatty acid transport via diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
is: SBO:0000185

metaR r0470
kinetic law: MODEL1310110057#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110057#
fast: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reversible: true
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is described by: ECO:0000000

metaM co2 x
initial concentration: 1.0
boundary condition: false
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
is: CHEBI:16526
has only substance units: false
is: HMDB01967
name: carbon dioxide

http://identifiers.org/biomodels.db/MODEL1310110057#_a4b0cc7c_f070_4ced_ba3a_11c3a9736322
initial concentration: NaN
boundary condition: true
name: GLB1
is: P16278
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2720
constant: false

metaR GULNter
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: L-gulonate endoplasmic reticular export
reversible: false
fast: false
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#

metaM cit e
is: SBO:0000247
has only substance units: false
is: CHEBI:16947
is: HMDB00094
initial concentration: 1.0
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
constant: false
type: Species
initial amount: NaN
boundary condition: false
name: citrate(3-)

metaR S6T17g
fast: false
is: SBO:0000176
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
product: MODEL1310110057#
modifier: MODEL1310110057#

metaM adrncrn c
is: HMDB00062
name: Adrenyl carnitine
is: C00318
boundary condition: false
constant: false
is: CHEBI:16347
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C29H49NO4 CHARGE: 0
has only substance units: false

metaM 3sala c
initial concentration: 1.0
is: CHEBI:61085
initial amount: NaN
type: Species
constant: false
is: C00606
boundary condition: false
name: 3-Sulfino-L-alanine
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606

metaM prgstrn e
name: progesterone
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:17026
is: HMDB01830
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410

metaM focytC m
boundary condition: false
type: Species
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16928
constant: false
has only substance units: false
name: Ferrocytochrome C
initial amount: NaN

metaR r0743
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
reactant: MODEL1310110057#
is described by: ECO:0000000
fast: false
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
is: SBO:0000176

metaM dcmp n
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01202
is: CHEBI:57566
type: Species
name: dCMP(2-)
constant: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239

metaR r2525
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110057#
reversible: true

metaR FAOXC200180m
modifier: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
reversible: false
name: Beta oxidation of long chain fatty acid
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#

metaM dmhptcrn e
name: 2,6 dimethylheptanoyl carnitine
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
initial concentration: 1.0
has only substance units: false
is: HMDB06320
boundary condition: false

metaR PI4P3K
type: Reaction
fast: false
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.1.153
is: SBO:0000176
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.1.154
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
name: phosphatidylinositol 4-phosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.11.1

http://identifiers.org/biomodels.db/MODEL1310110057#_93eab590_2db7_4c09_9c6b_2ce1cc78596a
is encoded by: hsa:482
has only substance units: false
has part: P14415
name: ATP1A3:ATP1B2
boundary condition: true
is: SBO:0000297
type: Species
initial concentration: NaN
initial amount: NaN
constant: false

metaM ksi deg29 l
boundary condition: false
type: Species
is: HMDB00143
is: CHEBI:12936
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
initial amount: NaN
initial concentration: 1.0
constant: false
name: keratan sulfate I, degradation product 29
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_09dc5c1f_1e29_4c67_a94d_9cd689208c4b
is: P19440
has only substance units: false
initial amount: NaN
name: GGT1
is encoded by: hsa:2678
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_38c5a49b_43c5_4c59_97dc_0be0a7ff68f0
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is: P36269
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2687
name: GGT5

http://identifiers.org/biomodels.db/MODEL1310110057#_323c535d_9726_4bd8_bad8_047aef55f710
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:LOC647190
constant: false
name: _LOC647190_1_c

metaR ACOAD9m
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
type: Reaction
reactant: MODEL1310110057#
product: MODEL1310110057#
reversible: false
is: SBO:0000176
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial
fast: false
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR sink tetdec2coa LPAREN c RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDEC2COASINK
type: Reaction

metaR ASNSERNaEx
type: Reaction
reactant: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000269
name: L-serine/L-asparagine Na-dependent exchange (Asn-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110057#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110057#_8579307d_7c88_4467_b97d_897579e68b08
type: Species
name: FASN
is encoded by: hsa:2194
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: P49327
has only substance units: false
boundary condition: true
constant: false

metaM cit c
initial amount: NaN
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
name: Citrate
has only substance units: false
is: C00158
is: SBO:0000247
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: HMDB00094
is: CHEBI:16947

metaR RE2814M
reversible: true
name: RE2814
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000000
product: MODEL1310110057#
fast: false

metaR r0472
type: Reaction
is: SBO:0000176
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
product: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reversible: true
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

metaR r0741
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
is: SBO:0000176
product: MODEL1310110057#
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110057#
reactant: MODEL1310110057#

metaM hxcoa m
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
is: HMDB06522
type: Species
name: Hexanoyl-CoA (n-C6:0CoA)
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM cortsn r
has only substance units: false
notes: FORMULA: C21H28O5 CHARGE: 0 INCHI: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00762
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB02802
type: Species
name: cortisone
is: CHEBI:16962
boundary condition: false

metaR DURIPP
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.3
modifier: MODEL1310110057#
fast: false
type: Reaction
product: MODEL1310110057#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
name: deoxyuridine phosphorylase
is: SBO:0000176
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_4833a5ea_349d_4c8e_89ec_27250b38e9e0
is: Q53H96
constant: false
is encoded by: hsa:65263
is: SBO:0000252
name: PYCRL
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR GCC2am
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.8.1.4
kinetic law: MODEL1310110057#
reversible: true
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.1.2.10
type: Reaction
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.4.4.2
product: MODEL1310110057#
is: SBO:0000176
fast: false
name: glycine-cleavage complex (lipoamide), mitochondrial
modifier: MODEL1310110057#

metaM c226crn c
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
constant: false
initial amount: NaN
is: HMDB06510
name: cervonyl carnitine
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/127055

metaM prgstrn c
initial amount: NaN
boundary condition: false
is: HMDB01830
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
name: progesterone
is: CHEBI:17026
is: SBO:0000247

metaM ethamp c
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:58190
initial amount: NaN
constant: false
is: HMDB00224
type: Species
is: SBO:0000247
name: ethamp[c]

http://identifiers.org/biomodels.db/MODEL1310110057#_daf87bd2_d281_46aa_9b7f_ac0615b54aeb
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: LDHC
has only substance units: false
is encoded by: hsa:3948
is: P07864
is: SBO:0000252
constant: false

metaM e4p c
is: CHEBI:16897
initial amount: NaN
is: C00279
name: D-Erythrose 4-phosphate
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
initial concentration: 1.0
is: HMDB01321
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_84eb4a4c_db5a_474c_995f_a895b4aeb9b6
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: Q53H96
name: PYCRL
is encoded by: hsa:65263
boundary condition: true

metaM dmhptcrn c
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB06320
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
initial concentration: 1.0
type: Species
name: 2,6 dimethylheptanoyl carnitine
has only substance units: false

metaM 6a2ohxnt x
name: 6-amino-2-oxohexanoic acid
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: CHEBI:17534
boundary condition: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
is: HMDB12151
is: SBO:0000247
initial concentration: 1.0

metaR FAS80COA L
product: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
is: SBO:0000176
fast: false
is described by: ECO:0000269
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#

metaR LPASE
reversible: false
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.5
name: lysophospholipase
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (5321.1) or (1178.1) or (29124.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9430701 NOTES:phosphatidyl choline degradation NJ
fast: false
reactant: MODEL1310110057#
modifier: MODEL1310110057#

metaR IVCRNe
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of isovaleryl carnitine into the extra cellular space
type: Reaction

metaM fuc L e
initial amount: NaN
is: CHEBI:18287
is: SBO:0000247
has only substance units: false
constant: false
type: Species
name: L-fucose
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
is: HMDB00174
boundary condition: false
initial concentration: 1.0

metaR ATPH1e
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (954.1) or (954.2) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
name: ATP diphosphohydrolase
is described by: ECO:0000269
kinetic law: MODEL1310110057#
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.6
product: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is: SBO:0000176

metaM biliverd c
constant: false
name: biliverdin(2-)
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:57991
is: HMDB01008

metaR IPDPtx
type: Reaction
is: SBO:0000185
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
name: Isopentenyl diphosphate transport (peroxisome)
fast: false
is described by: ECO:0000134
reversible: true
product: MODEL1310110057#
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_b8d05ecb_4d74_4efb_8e1f_dca66138bbdb
initial amount: NaN
is encoded by: hsa:56606
initial concentration: NaN
has only substance units: false
boundary condition: true
name: SLC2A9
constant: false
is: SBO:0000252
type: Species

metaM dtdp c
is: HMDB01274
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
name: dTDP
initial amount: NaN
is: C00363
initial concentration: 1.0
is: CHEBI:58369
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
type: Species

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR MALtm
product: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
fast: false
kinetic law: MODEL1310110057#
reversible: true
name: malate transport, mitochondrial
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110057#
modifier: MODEL1310110057#

metaM rbt e
is: HMDB00508
boundary condition: false
name: D-ribitol
has only substance units: false
is: CHEBI:15963
initial amount: NaN
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM CE5117 m
constant: false
is: CHEBI:57923
type: Species
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
initial concentration: 1.0
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false

metaM nad x
is: HMDB00902
boundary condition: false
has only substance units: false
constant: false
is: C00003
name: Nicotinamide adenine dinucleotide
type: Species
is: CHEBI:57540
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3305

metaR r2521
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
is: SBO:0000185
product: MODEL1310110057#
reversible: true
kinetic law: MODEL1310110057#
name: Utilized transport
type: Reaction
reactant: MODEL1310110057#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110057#_6db65a90_75b9_4da5_8058_6ab2b6365a81
is: Q9HC58
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:57419
name: SLC24A3

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

metaM HC02020 r
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C43H76O2 CHARGE: 0 INCHI: InChI=1S/C43H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-23-41(44)45-36-28-30-42(5)35(32-36)24-25-37-39-27-26-38(34(4)22-20-21-33(2)3)43(39,6)31-29-40(37)42/h24,33-34,36-40H,7-23,25-32H2,1-6H3/t34-,36+,37+,38-,39+,40+,42+,43-/m1/s1
name: Cholesterol-ester-palm
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:3663
is: SBO:0000247

metaM val L m
is: HMDB00883
boundary condition: false
constant: false
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial concentration: 1.0
name: L-valine
is: CHEBI:16414
initial amount: NaN

metaM lthstrl r
type: Species
is: CHEBI:17168
constant: false
is: HMDB01170
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
initial concentration: 1.0
is: SBO:0000247
name: 5alpha-cholest-7-en-3beta-ol
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110057#_280d27e0_2778_419f_adab_548e47d8caad
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial concentration: NaN
name: INPPL1
initial amount: NaN
boundary condition: true
is: O15357
is encoded by: hsa:3636

metaM ru5p D r
is: SBO:0000247
type: Species
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
constant: false
name: D-ribulose 5-phosphate(2-)
initial concentration: 1.0
is: HMDB00618
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:58121

metaM ppi r
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00250
name: Diphosphate
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0
is: CHEBI:33019
is: C00013
boundary condition: false

metaR FACOAL140i
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
name: fatty-acid--CoA ligase (tetradecanoate)
modifier: MODEL1310110057#
product: MODEL1310110057#
reversible: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000176

metaR GAL3ST11
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
reversible: false
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
type: Reaction
product: MODEL1310110057#
is described by: ECO:0000000
modifier: MODEL1310110057#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.11
name: Galactosylceramide sulfotransferase

metaR RE1897C
name: RE1897
kinetic law: MODEL1310110057#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
reactant: MODEL1310110057#
reversible: true
is described by: ECO:0000000
product: MODEL1310110057#
type: Reaction

metaR r2520
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110057#
kinetic law: MODEL1310110057#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
fast: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
reversible: true
type: Reaction

metaM fuc L c
has only substance units: false
initial amount: NaN
name: L-fucose
is: CHEBI:18287
is: SBO:0000247
type: Species
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
constant: false
is: HMDB00174
boundary condition: false
initial concentration: 1.0

metaM CE2705 c
initial concentration: 1.0
name: quinonoid dihydrobiopterin
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:36781
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
boundary condition: false

metaR DOLASNT Ler
type: Reaction
product: MODEL1310110057#
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.119
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (liver)
kinetic law: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
reversible: false
reactant: MODEL1310110057#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110057#_bc1d444f_4e10_49c2_bb6f_58e2bc890627
initial concentration: NaN
name: UPP1
is encoded by: hsa:7378
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

metaM dtdp e
is: CHEBI:58369
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274

metaR r1155
is described by: ECO:0000000
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
fast: false
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_9438a38e_9cc1_418e_87fc_043169a25912
is encoded by: hsa:3948
initial amount: NaN
name: LDHC
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
constant: false

metaR r1260
reactant: MODEL1310110057#
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: EC:6.2.1.3
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110057#

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaM rbt c
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00508
is: CHEBI:15963
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
type: Species
initial amount: NaN
initial concentration: 1.0
name: D-ribitol

metaR TTDCAtr
reversible: true
kinetic law: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
name: tetradecanoate (transport)
is: SBO:0000185
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_14928c37_7311_4d0e_806b_316d05f315a4
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
name: UROD
type: Species
is encoded by: hsa:7389
is: P06132

metaR RAI1
reversible: true
kinetic law: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000176
name: retinal isomerase (11-cis)
fast: false
product: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110057#_6877c9cc_d1c1_44b6_8930_dbfca4950514
constant: false
name: SLC20A1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is: Q8WUM9
has only substance units: false
is encoded by: hsa:6574
boundary condition: true

metaR r1156
kinetic law: MODEL1310110057#
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
reactant: MODEL1310110057#
is: SBO:0000176

metaR CSNATer
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (1384.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:11257506,PMID:3759988 NOTES:mm
is described by: ECO:0000254
product: MODEL1310110057#
name: carnitine O-acetyltransferase, endolasmic reticulum
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.3.1.7
is: SBO:0000176
type: Reaction

metaM co2 r
name: CO2
is: SBO:0000247
is: CHEBI:16526
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
type: Species
initial concentration: 1.0
is: HMDB01967
boundary condition: false
constant: false
is: C00011
initial amount: NaN
has only substance units: false

metaR TXASr
name: Thromboxane-A synthase
type: Reaction
is described by: ECO:0000134
reversible: false
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.99.5
reactant: MODEL1310110057#
fast: false
modifier: MODEL1310110057#
product: MODEL1310110057#
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_9a4f2e46_80e5_4f75_9f9d_8c605ee608b8
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:AV717590
is: SBO:0000252
name: _AV717590_1_m
boundary condition: true
type: Species

metaR FAOXC80
modifier: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110057#
name: Beta oxidation of med/long chain fatty acid
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
reversible: false
product: MODEL1310110057#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_ae6692d9_5271_428b_aa56_178785833a8f
boundary condition: true
has only substance units: false
is: SBO:0000252
name: GBA
type: Species
constant: false
is encoded by: hsa:2629
initial concentration: NaN
is: B7Z5G2
initial amount: NaN

metaR RETH
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT
is version of: http://identifiers.org/ec-code/3.1.1.3
fast: false
is described by: ECO:0000000
product: MODEL1310110057#
is: SBO:0000176
name: retinyl ester hydrolase
modifier: MODEL1310110057#
reversible: false
type: Reaction
reactant: MODEL1310110057#

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_9eb77d7b_a9c5_4b01_afa0_1dac0bed7df5
name: SLC17A1
is: SBO:0000252
is encoded by: hsa:6568
is: Q14916
constant: false
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN

metaR COQ5m
fast: false
reactant: MODEL1310110057#
is described by: ECO:0000000
type: Reaction
name: Ubiquinone biosynthesis methyltransferase COQ5
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:_2.1.1.- IT
reversible: false
kinetic law: MODEL1310110057#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110057#_e1f16625_3531_4ded_9747_3c8f4d8ccf11
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q13423
is encoded by: hsa:23530
name: NNT

http://identifiers.org/biomodels.db/MODEL1310110057#_metaR_ACGALFUCGALACGALFUC12GAL14ACGLCGALGLUSIDEte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
name: blood group intracellular transport
type: Reaction
product: MODEL1310110057#

metaR PRPPS
name: phosphoribosylpyrophosphate synthetase
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110057#
product: MODEL1310110057#
modifier: MODEL1310110057#
reversible: true
is: SBO:0000176
reactant: MODEL1310110057#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.6.1

http://identifiers.org/biomodels.db/MODEL1310110057#_82de98ce_0ac8_4687_8ed1_80955b0a565d
constant: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000297
has only substance units: false
name: NME1:NME2
is encoded by: hsa:4830

http://identifiers.org/biomodels.db/MODEL1310110057#_afd8faf6_5765_4a21_9a23_837e9d1a1a30
initial amount: NaN
constant: false
name: PLCD3
is encoded by: hsa:113026
boundary condition: true
is: SBO:0000252
type: Species
is: Q8N3E9
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_a51cfad0_b6ca_49d3_9154_4a514528d347
name: NT5C
initial concentration: NaN
boundary condition: true
is encoded by: hsa:30833
type: Species
is: SBO:0000252
constant: false
is: Q8TCD5
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_41fce0d9_9510_475c_a1c9_2faf643820a4
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
name: HAO1
initial amount: NaN
is: SBO:0000252
type: Species
is: Q9UJM8
is encoded by: hsa:54363

http://identifiers.org/biomodels.db/MODEL1310110057#_a5c80203_a9ba_4399_9a79_d2dfd82556e9
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
name: ADSL
initial amount: NaN
is encoded by: hsa:158
boundary condition: true

metaR BALAtmr
reactant: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
kinetic law: MODEL1310110057#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110057#
name: Beta-alanine reversible mitochondrial transport (diffusion)

metaR r0309
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
kinetic law: MODEL1310110057#
is: SBO:0000176
name: trans-Hexadec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is version of: http://identifiers.org/ec-code/1.4.3.22
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
reversible: true

metaR EX doco13ac
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_b5469064_11a7_462d_a25a_aee9a92b62f1
is: SBO:0000252
is: P19801
type: Species
is encoded by: hsa:26
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
name: ABP1
boundary condition: true

metaR r1154
product: MODEL1310110057#
fast: false
is described by: ECO:0000000
type: Reaction
name: EC:1.2.7.2
reversible: true
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110057#_87a2912a_28ae_49c9_8ba3_845d2dd3d25a
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P17050
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:4668
name: NAGA

metaM g1m8mpdol L r
boundary condition: false
initial concentration: 1.0
is: C05870
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C1840H3028N20O670P20 CHARGE: -20
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
is: SBO:0000247

metaM ptdca c
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/22169126
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
is: HMDB00826
name: pentadecanoate
boundary condition: false
type: Species
initial amount: NaN

metaR HEXCOAACBP
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexanoyl-CoA (n-C6:0CoA) from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_1c2e0d4e_6cd4_4099_8892_ae3976e37e62
name: RDH16
is: SBO:0000252
is: O75452
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:8608

metaM ascb L e
constant: false
boundary condition: false
name: L-ascorbate
is: CHEBI:38290
has only substance units: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: HMDB00044
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN

metaM octdececoa m
name: octadecenoylcoa
initial amount: NaN
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/5280355
is: SBO:0000247
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species

metaM c81crn e
notes: FORMULA: C15H27NO4 CHARGE: 0
is: HMDB13324
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
name: octenoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110057#_ead6b9ab_c57d_43e2_abd2_060a05eaa061
initial concentration: NaN
boundary condition: true
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:84076
is: SBO:0000252
has only substance units: false
is: Q9H0I9
name: TKTL2

metaM hxcoa c
is: SBO:0000247
type: Species
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
is: HMDB13130
constant: false
has only substance units: false
initial amount: NaN
name: Hexanoyl-CoA (n-C6:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110057#_eab3e32b_e2b7_4f3e_a2d4_62e77be706ba
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:1345
has only substance units: false
is: P09669
name: COX6C
boundary condition: true
is: SBO:0000252
type: Species

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

metaM HC02217 c
is: CHEBI:27647
boundary condition: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
name: prostaglandin-g2
initial amount: NaN
has only substance units: false

metaM pail35p hs c
is: CHEBI:57923
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
has only substance units: false
boundary condition: false

metaM retn r
is: HMDB01852
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial amount: NaN
has only substance units: false
is: CHEBI:35291
name: all-trans-retinoate
boundary condition: false
initial concentration: 1.0

metaM ksi g
has only substance units: false
initial concentration: 1.0
is: HMDB01644
boundary condition: false
name: keratan sulfate I
is: CHEBI:17140
initial amount: NaN
constant: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: SBO:0000247
type: Species

metaR FAOXC102C81x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)x
type: Reaction

metaR ICDHyrm
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110057#
reversible: true
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
is version of: http://identifiers.org/ec-code/1.1.1.42
name: Isocitrate dehydrogenase (NADP+)
product: MODEL1310110057#
modifier: MODEL1310110057#

metaR RE1530M
is: SBO:0000176
is described by: ECO:0000000
name: RE1530
type: Reaction
modifier: MODEL1310110057#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.21
fast: false
reactant: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (7084.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
kinetic law: MODEL1310110057#

metaM 2dodtricoa m
is: HMDB11123
constant: false
initial amount: NaN
name: 2,6,9-dodecatrienoylcoa
type: Species
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: C05279

metaR NDPK4n
kinetic law: MODEL1310110057#
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
reactant: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
is described by: ECO:0000304
modifier: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_04a6f2a0_16fd_4db4_b7ff_71501c37fcb2
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: P61457
is encoded by: hsa:5092
is: SBO:0000252
name: PCBD1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_1ab6dace_0492_439b_b090_6f6316ab2299
has only substance units: false
is: P07203
initial concentration: NaN
constant: false
is: SBO:0000252
name: GPX1
initial amount: NaN
boundary condition: true
is encoded by: hsa:2876
type: Species

metaM crtsl r
notes: FORMULA: C21H30O5 CHARGE: 0 INCHI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00735
constant: false
type: Species
boundary condition: false
name: cortisol
is: HMDB00063
initial concentration: 1.0
is: CHEBI:17650
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaM ascb L c
boundary condition: false
name: L-ascorbate
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: CHEBI:38290
is: HMDB00044
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM ptdca e
type: Species
name: pentadecanoate
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/22169126
boundary condition: false
is: HMDB00826
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)

metaR RE2445E
is: SBO:0000176
reactant: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (1636.1) or (59272.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.15.1 Confidence Level: 0 AUTHORS: PMID:11244003 NOTES:
name: RE2445
type: Reaction
modifier: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.17.23
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.4.15.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_36ae5889_4687_49d0_a673_38916c145bc1
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: C5HZ13
name: CLC
boundary condition: true
is encoded by: hsa:1178

metaM amp c
name: AMP
is: SBO:0000247
boundary condition: false
is: C00020
is: CHEBI:3322
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2
constant: false
is: HMDB00045
type: Species
has only substance units: false

metaM HC00900 c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: Methylmalonate
has only substance units: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
type: Species
is: CHEBI:30860
constant: false
boundary condition: false

metaM CE2705 n
is: HMDB02281
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
constant: false
is: CHEBI:15374
name: quinonoid dihydrobiopterin
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_7f624b31_007a_49de_843c_e37670f7385b
is encoded by: hsa:250
is: P05187
name: ALPP
initial concentration: NaN
constant: false
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaM ksii core4 pre10 g
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
type: Species
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 10
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0

metaR r0907
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110057#
name: Active transport
type: Reaction
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110057#

metaR ABUTt2r
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
product: MODEL1310110057#
name: 4-aminobutyrate reversible transport in via proton symport
reactant: MODEL1310110057#
reversible: true
kinetic law: MODEL1310110057#
fast: false
is described by: ECO:0000304
is: SBO:0000185
modifier: MODEL1310110057#

metaM HC02217 e
constant: false
is: SBO:0000247
has only substance units: false
name: prostaglandin-g2
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
boundary condition: false
is: CHEBI:27647

metaR LYStip
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
reactant: MODEL1310110057#
is: SBO:0000185
name: L-lysine transport, peroxisomal (irreversible)
product: MODEL1310110057#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_6dcccc5e_7527_4c4c_a68b_9eb584c5cb4c
is encoded by: hsa:5236
is: SBO:0000252
name: PGM1
initial amount: NaN
constant: false
is: B4DPV0
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM 4abutn e
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
initial concentration: 1.0
name: 4-ammoniobutanal
is: HMDB01080
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:58264
constant: false
boundary condition: false
initial amount: NaN

metaR FAOXC204C184m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_c8492bbf_07c4_4653_af23_3f06fc709421
is: A8K7W0
name: VNN2
is encoded by: hsa:8875
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false

metaR r0908
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
product: MODEL1310110057#
is: SBO:0000185
reactant: MODEL1310110057#
type: Reaction
name: Postulated transport reaction

metaR FAOXC1811601m
reactant: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110057#
name: Beta oxidation fatty acid

metaR PROSTGE2t2
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110057#
fast: false
name: prostaglandin uniport
product: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_06ef6dd3_1620_4d83_903b_66a820286d5b
has only substance units: false
constant: false
type: Species
boundary condition: true
initial concentration: NaN
name: SULT1A3
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6818

metaR 3SPYRSPm
reversible: false
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110057#
is: SBO:0000176
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
product: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_c1cb12e0_c377_4f2a_8977_de932fce2061
is encoded by: hsa:AI348006
constant: false
initial concentration: NaN
name: _AI348006_1_c
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_e1d0b011_1314_41b3_93d8_5b5e9b42d0e8
is: B5MCC7
is encoded by: hsa:52
name: ACP1
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_metaR_ACGALFUCGALACGALFUC12GAL14ACGLCGALGLUSIDEtg
product: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is described by: ECO:0000000
fast: false
reactant: MODEL1310110057#
reversible: true
kinetic law: MODEL1310110057#
type: Reaction
name: blood group intracellular transport

metaM fuc L l
name: L-fucose
is: HMDB00174
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:18287
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
has only substance units: false
constant: false
boundary condition: false
type: Species

metaR RE0936E
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110057#
fast: false
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (59272.1) SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 0 AUTHORS: PMID:10969042,PMID:11815627 NOTES:
type: Reaction
name: RE0936
is version of: http://identifiers.org/ec-code/3.4.17.23
product: MODEL1310110057#
reactant: MODEL1310110057#
reversible: true

metaM amp e
is: SBO:0000247
has only substance units: false
name: AMP
is: C00020
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00045
initial concentration: 1.0
type: Species
is: CHEBI:456215

metaR r0909
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
type: Reaction
name: Transport reaction
kinetic law: MODEL1310110057#
product: MODEL1310110057#
fast: false
is: SBO:0000185
reactant: MODEL1310110057#
reversible: true

metaR LEUTAm
product: MODEL1310110057#
is: SBO:0000176
reactant: MODEL1310110057#
reversible: true
name: leucine transaminase, mitochondrial
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
kinetic law: MODEL1310110057#
fast: false
type: Reaction
modifier: MODEL1310110057#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42

http://identifiers.org/biomodels.db/MODEL1310110057#_0acb2682_40c8_4333_9806_8fdd39896ab9
is: Q4J699
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:491
name: ATP2B2
type: Species

metaM ksi l
is: CHEBI:57455
initial concentration: 1.0
is: C00445
name: keratan sulfate I
constant: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
initial amount: NaN
type: Species
is: HMDB01354
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR DOPABMO
fast: false
product: MODEL1310110057#
type: Reaction
reversible: false
kinetic law: MODEL1310110057#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.17.1
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (26002.1) or (1621.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.17.1 Confidence Level: 4 AUTHORS: NOTES:SAB
is: SBO:0000176
name: dopamine beta-monooxygenase
modifier: MODEL1310110057#

metaR RE1448N
is described by: ECO:0000000
product: MODEL1310110057#
name: RE1448
is: SBO:0000176
kinetic law: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_758dfa36_65e7_4ea1_b855_8b9343e13bf3
initial amount: NaN
constant: false
is encoded by: hsa:218
name: ALDH3A1
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is: P30838

metaM hxan e
constant: false
name: hypoxanthine
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:17368
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
has only substance units: false
type: Species
is: HMDB00157

http://identifiers.org/biomodels.db/MODEL1310110057#_c5a42cd6_dbb3_4815_8710_ee00cd5ab540
boundary condition: true
has only substance units: false
is encoded by: hsa:AA081045
name: _AA081045_1_e
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_c0bc8156_21c9_47ce_a267_3c205277fd16
is: SBO:0000252
is encoded by: hsa:4720
type: Species
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is: B7Z792
has only substance units: false
name: NDUFS2

metaM dtdp m
type: Species
initial amount: NaN
name: dTDP
is: HMDB01274
is: CHEBI:58369
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial concentration: 1.0
boundary condition: false
constant: false
is: C00363

http://identifiers.org/biomodels.db/MODEL1310110057#_4a13a64c_61eb_4efb_9576_780b5988ba35
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: Q6IBC0
initial amount: NaN
is encoded by: hsa:3155
type: Species
name: HMGCL

metaR FATP6t
type: Reaction
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.7
kinetic law: MODEL1310110057#
fast: false
is: SBO:0000185
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
modifier: MODEL1310110057#
name: fatty acid electroneutral transport

metaM 4abutn c
initial concentration: 1.0
name: 4-Aminobutanal
is: C00555
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: HMDB01080
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:58264
is: SBO:0000247
constant: false
initial amount: NaN

metaR 3HLYTCL
name: 3-Hydroxy-L-tyrosine carboxy-lyase
modifier: MODEL1310110057#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: NOTES:SAB
is version of: http://identifiers.org/ec-code/4.1.1.28
product: MODEL1310110057#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_07db5222_f4b8_4bf9_8498_d569f40ab304
boundary condition: true
is: SBO:0000252
type: Species
name: ATP1A1
is encoded by: hsa:476
initial concentration: NaN
is: B7Z3U6
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_be9b97b5_9c26_425b_9dc8_858431b016e2
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AA203143
name: _AA203143_1_c
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false

metaM c81crn c
type: Species
boundary condition: false
notes: FORMULA: C15H27NO4 CHARGE: 0
is: HMDB13324
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
name: octenoyl carnitine

metaR C6CRNe
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexanoyl carnitine into the extra cellular fluid
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_d28c6102_ea6c_4bfa_9ef6_5664628fc2b9
constant: false
has only substance units: false
is encoded by: hsa:5335
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is: P19174
initial amount: NaN
name: PLCG1

metaM nad r
is: HMDB00902
initial concentration: 1.0
name: NAD(1-)
boundary condition: false
type: Species
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
constant: false
is: SBO:0000247
is: CHEBI:57540
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_8224305e_f2bf_4835_8f4a_120f9493ba32
name: PIGO
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:84720
is: SBO:0000252
type: Species

metaR r2199
reactant: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110057#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
kinetic law: MODEL1310110057#
reversible: true
fast: false
modifier: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_213c66ed_2a8e_45c5_9a63_6447fbc54ac1
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:953
initial amount: NaN
is: Q86VV3
constant: false
boundary condition: true
name: ENTPD1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_029543a9_aa61_40d1_86d9_8382082b92c9
initial amount: NaN
has only substance units: false
is encoded by: hsa:56954
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
name: NIT2
is: Q9NQR4
boundary condition: true

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

metaR ASNTHRNaEx
product: MODEL1310110057#
reversible: false
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
type: Reaction
name: L-threonine/L-asparagine Na-dependent exchange (Asn-L in)
is: SBO:0000185
reactant: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#

metaR DAG HSter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110057#
name: diacylglycerol ER export
kinetic law: MODEL1310110057#
is described by: ECO:0000000
product: MODEL1310110057#
reversible: false

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_17112354_eb36_426b_a17b_2d1e01683df7
name: HYAL3
constant: false
is encoded by: hsa:8372
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is: O43820

metaR B3GNT34g
reversible: false
is: SBO:0000176
reactant: MODEL1310110057#
type: Reaction
modifier: MODEL1310110057#
product: MODEL1310110057#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus

metaM ksi pre22 g
initial amount: NaN
type: Species
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
is: CHEBI:58053
boundary condition: false
initial concentration: 1.0
is: C00130
is: SBO:0000247
is: HMDB00175
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 22
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_cca1c3cc_81b4_42ce_98d6_6c4099acdc05
is: P59796
initial concentration: NaN
is encoded by: hsa:257202
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: GPX6
boundary condition: true
constant: false
type: Species

metaR DPPS
type: Reaction
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
name: decaprenyl synthase
product: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 2 AUTHORS: PMID:16262699 NOTES:by analogy to other dimethyl transferase rxns. See PMID: 10586494, human interemidate (from C15 ->C50) not explicitly determined yet, however it is known to occur since this pathway is essential in Q10 synthesis. For human metabolism: may be associated w/ GeneID: 23590 TPRT - recheck lit in future IT and NJ
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110057#_14f5aa64_1064_4f4c_a9f6_db35067af90f
initial amount: NaN
name: PANK1
is: SBO:0000252
constant: false
is encoded by: hsa:53354
is: Q8TE04
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR ABUTD
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
product: MODEL1310110057#
reactant: MODEL1310110057#
modifier: MODEL1310110057#
name: Aminobutyraldehyde dehydrogenase
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_2c4cf04b_51d5_4e9a_a4de_a3443d9b57b5
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
name: ACSL1
is encoded by: hsa:2180
is: P33121
type: Species
constant: false
initial amount: NaN

metaM nad m
name: Nicotinamide adenine dinucleotide
has only substance units: false
type: Species
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00902
is: http://identifiers.org/pubchem.compound/3305
initial amount: NaN
is: CHEBI:57540
is: C00003
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110057#_f3cd7160_4210_49f4_a94d_e676b512e68d
is: SBO:0000252
name: TKTL1
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:8277
is: B7Z7I0

metaR FAOXC2051843m
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
reversible: false
reactant: MODEL1310110057#
product: MODEL1310110057#
name: Beta oxidation of fatty acid
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
is described by: ECO:0000000

metaR LEUtec
modifier: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
is described by: ECO:0000269
name: L-leucine transport via diffusion (extracellular to cytosol)
type: Reaction
reversible: true
kinetic law: MODEL1310110057#
fast: false
is: SBO:0000185
product: MODEL1310110057#

metaR DOLP Lter
is described by: ECO:0000000
type: Reaction
product: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: dolichol phosphate flippase (liver)
is: SBO:0000176
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
reversible: false

metaR GBA
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.45
reversible: false
product: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110057#
name: Glucosylceramidase
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaM sgalside hs l
is: SBO:0000247
constant: false
has only substance units: false
name: sulfatide galactocerebroside
is: HMDB00904
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
is: CHEBI:16349
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species

metaR AG13T5g
product: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
reversible: false
modifier: MODEL1310110057#
is described by: ECO:0000000
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110057#
is: SBO:0000176

metaM adpac x
notes: FORMULA: C6H8O4 CHARGE: -2
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00448
constant: false
is: SBO:0000247
type: Species
name: adipic acid

metaM xoltetrol c
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:17278
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB01231
type: Species

metaR r1559
reactant: MODEL1310110057#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110057#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110057#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110057#_1f14bd2e_3b69_4978_a398_39d775ce54fb
constant: false
boundary condition: true
is: O75438
name: NDUFB1
type: Species
is encoded by: hsa:4707
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR ATPtx
is: SBO:0000185
reversible: true
product: MODEL1310110057#
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
name: ATP transporter, peroxisomal
reactant: MODEL1310110057#

metaM ahcys e
name: S-Adenosyl-L-homocysteine
is: SBO:0000247
boundary condition: false
is: CHEBI:16680
type: Species
initial amount: NaN
is: HMDB00939
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C14H20N6O5S CHARGE: 0
is: C00021

metaM cmp g
constant: false
name: CMP(2-)
initial concentration: 1.0
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00095
is: CHEBI:60377
initial amount: NaN

metaR C121CPT1
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecenoylcarnitine
type: Reaction

metaR r1401
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
is version of: http://identifiers.org/ec-code/2.7.10.1
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.2.1.35
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.3.1.41
is: SBO:0000185
reactant: MODEL1310110057#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.51
fast: false
is described by: ECO:0000000
name: Facilitated diffusion
type: Reaction
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.1.1.3

metaR GBSIDEtl
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) NJ
product: MODEL1310110057#
fast: false
type: Reaction
name: globoside intracellular transport
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#

metaR NDP8
is: SBO:0000176
product: MODEL1310110057#
is described by: ECO:0000269
reactant: MODEL1310110057#
reversible: false
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
name: nucleoside-diphosphatase (dUDP)
is version of: http://identifiers.org/ec-code/2.7.4.9
kinetic law: MODEL1310110057#
fast: false
modifier: MODEL1310110057#

metaM m4mpdol L r
is: SBO:0000247
boundary condition: false
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
is: CHEBI:37633
type: Species
initial concentration: 1.0

metaM ksii core2 pre6 g
is: SBO:0000247
notes: FORMULA: C61H98N5O46SX CHARGE: -2
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:28067
type: Species
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 6
initial amount: NaN

metaR NDP8ex
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
kinetic law: MODEL1310110057#
type: Reaction
fast: false
name: nucleoside-diphosphatase (UTP), extracellular
modifier: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.6
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110057#_a1694c25_9223_4fd5_b52c_4555254dd5b4
initial concentration: NaN
initial amount: NaN
name: SLC46A1
type: Species
constant: false
is encoded by: hsa:113235
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q96NT5

metaM h r
constant: false
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: C00080
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
name: proton
initial amount: NaN
boundary condition: false
is: CHEBI:24636
type: Species

metaR NADPHtxu
kinetic law: MODEL1310110057#
type: Reaction
is described by: ECO:0000000
name: NADPH transporter, peroxisome
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ free hydrogens NJ
reversible: false
is: SBO:0000185
product: MODEL1310110057#
reactant: MODEL1310110057#

metaR M4MPDOL Lter
reversible: false
is: SBO:0000185
fast: false
name: m4mpdol flippase
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110057#
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110057#_dadecb0b_d90a_475f_a4d9_0f012bfbe2d5
boundary condition: true
type: Species
is encoded by: hsa:11136
is: P82251
is: SBO:0000252
name: SLC7A9
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM dtdp n
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
boundary condition: false
is: SBO:0000247
is: HMDB01274
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
initial concentration: 1.0
is: CHEBI:58369
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_6b8ea0f2_14ec_4623_84da_c9781dde4947
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: Q10472
is: SBO:0000252
is encoded by: hsa:2589
has only substance units: false
name: GALNT1

metaM glx m
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00119
name: glyoxylate
is: CHEBI:36655
has only substance units: false
initial amount: NaN
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
constant: false
type: Species

metaM 3ivcrn e
constant: false
boundary condition: false
is: HMDB13336
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C12H23NO5 CHARGE: 0
name: 3-hydroxy-isovaleryl carnitine
type: Species

metaR TRPHYDRO2
reactant: MODEL1310110057#
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
is described by: ECO:0000269
product: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
type: Reaction
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.14.16.4

http://identifiers.org/biomodels.db/MODEL1310110057#_752a7260_734f_4999_bce2_5a12ec9fef12
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
name: _2544_1_c
is encoded by: hsa:2544
boundary condition: true
type: Species

metaR LPS3
fast: false
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (11343.1) or (11343.2) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.23 Confidence Level: 4 AUTHORS: PMID:9495531 NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110057#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.23
is: SBO:0000176
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
name: lipase

metaM ahcys c
type: Species
is: HMDB00939
has only substance units: false
is: CHEBI:16680
initial concentration: 1.0
name: S-Adenosyl-L-homocysteine
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
initial amount: NaN
is: C00021
constant: false
boundary condition: false
is: SBO:0000247

metaR r1400
type: Reaction
is: SBO:0000185
reactant: MODEL1310110057#
reversible: false
fast: false
product: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
is described by: ECO:0000000
name: Active transport

metaM omhpal r
notes: FORMULA: C16H30O3 CHARGE: -1
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
name: w-hydroxypalmiticacid
boundary condition: false
is: HMDB06294
type: Species
has only substance units: false

metaR RTOTAL2t
kinetic law: MODEL1310110057#
name: RTOTAL2 transport
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_e0f7171c_dd1b_49be_bc5b_ed0e0da8fac1
constant: false
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: Q9NUB1
name: ACSS1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:84532

http://identifiers.org/biomodels.db/MODEL1310110057#_4689ea17_adf7_4d9d_86e4_2634ddb5be44
is: Q9Y227
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:9583
name: ENTPD4
type: Species
has only substance units: false
initial amount: NaN

metaR EX thym LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymine exchange
type: Reaction

metaM 3thexddcoacrn c
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB02014
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
type: Species
notes: FORMULA: C23H41NO5 CHARGE: 0

metaR 3DPHBH1
reactant: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212 NOTES:Used to make Ubiquinone-10 enzyme has not been identified yet. IT
name: Hydroxylation of 3-Decaprenyl-4-hydroxybenzoate (NADH)

metaR r0603
product: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
modifier: MODEL1310110057#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.12
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
type: Reaction
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: true

metaR MELATNOX
product: MODEL1310110057#
name: Melatonin:NADP oxidoreductase
kinetic law: MODEL1310110057#
type: Reaction
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.14.14.1
is version of: http://identifiers.org/ec-code/1.14.13.48
is described by: ECO:0000269
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (1557.1) or (1543.1) or (1545.1) or (1544.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15616152 NOTES:SAB made up name
reversible: false
fast: false
is: SBO:0000176

metaR LPS2
product: MODEL1310110057#
reversible: false
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
name: lipase
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.34
fast: false

metaM mi1p D c
constant: false
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
initial concentration: 1.0
is: HMDB02985
has only substance units: false
is: CHEBI:58433
type: Species
name: 1D-myo-inositol 1-phosphate(2-)
boundary condition: false
initial amount: NaN

metaM octdececoa c
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
name: octadecenoylcoa
is: HMDB06351
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4

metaR NDPK6n
product: MODEL1310110057#
is described by: ECO:0000304
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
reactant: MODEL1310110057#
reversible: true
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false
is: SBO:0000176

metaM CE2434 m
initial amount: NaN
type: Species
constant: false
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
has only substance units: false
is: CHEBI:57795
initial concentration: 1.0
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_7fe8c999_1130_4053_9e13_45df855ff0d0
constant: false
name: B3GNT5
initial concentration: NaN
is: Q9BYG0
is encoded by: hsa:84002
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR P450SCC1m
reactant: MODEL1310110057#
fast: false
is described by: ECO:0000134
product: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
reversible: true
name: cholesterol monooxygenase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110057#_7b54fe34_8119_4447_8f54_baacfedd86e0
constant: false
name: SLC5A5
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:6528
is: Q92911
is: SBO:0000252
initial concentration: NaN

metaR NACHEXA22ly
fast: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110057#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110057#
product: MODEL1310110057#
name: beta-N-acetylhexosaminidase A, lysosomal

metaR GLYCLTtp
is described by: ECO:0000000
type: Reaction
name: glycolate transport into peroxisome
product: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110057#_83e26afa_8d7e_4cb5_b604_3a11bc5aa91b
initial amount: NaN
is: SBO:0000252
constant: false
name: TKT
is encoded by: hsa:7086
boundary condition: true
is: E7EPA7
initial concentration: NaN
has only substance units: false
type: Species

metaR RE1532M
name: RE1532
modifier: MODEL1310110057#
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
product: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM 3ivcrn c
is: C05998
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB06870
is: SBO:0000247
notes: FORMULA: C12H23NO5 CHARGE: 0
is: http://identifiers.org/pubchem.compound/11966188
boundary condition: false
name: 3-hydroxy-isovaleryl carnitine

metaM nadp c
name: Nicotinamide adenine dinucleotide phosphate
initial concentration: 1.0
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
constant: false
boundary condition: false
is: HMDB00217
initial amount: NaN
is: SBO:0000247
is: C00006
type: Species
has only substance units: false
is: CHEBI:58349

metaR FTHFL
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110057#
is: SBO:0000176
product: MODEL1310110057#
type: Reaction
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.5.1.5
is described by: ECO:0000134
reactant: MODEL1310110057#
name: Formate-tetrahydrofolate ligase
reversible: true

metaR RNDR3
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 4 AUTHORS: PMID:14729598 NOTES:
reversible: false
product: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
is: SBO:0000176
fast: false
name: ribonucleoside-diphosphate reductase (CDP)
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000269
kinetic law: MODEL1310110057#

metaM ppi c
is: C00013
initial amount: NaN
name: Diphosphate
is: CHEBI:0
constant: false
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB00250
boundary condition: false

metaM tmndnccoa c
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
initial amount: NaN
is: HMDB06514
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
has only substance units: false
name: timnodonyl coenzyme A

metaR DUMPtn
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
name: dUMP nuclear transport
reactant: MODEL1310110057#

metaR r0604
kinetic law: MODEL1310110057#
is: SBO:0000176
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110057#
modifier: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_1cdd05a1_118d_4127_aa82_c0812bf78323
name: ADCY2
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is: Q71UM8
initial amount: NaN
is encoded by: hsa:108
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_71492641_cb85_48d0_8436_8cd167a8701a
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: A0PJH2
has only substance units: false
constant: false
name: ATP5H
is encoded by: hsa:10476

metaM 3thexddcoacrn e
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
notes: FORMULA: C23H41NO5 CHARGE: 0
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
is: HMDB02014

http://identifiers.org/biomodels.db/MODEL1310110057#_ac66a180_494f_4d17_b5f2_bc500bb20f66
initial amount: NaN
name: AK3
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
is: E7ET30
is encoded by: hsa:50808
boundary condition: true
type: Species

metaR NDPK6m
product: MODEL1310110057#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110057#
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
is described by: ECO:0000254
reactant: MODEL1310110057#
modifier: MODEL1310110057#
fast: false

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaR BIOCYTtn
fast: false
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
reversible: true
is described by: ECO:0000000
type: Reaction
name: biocytin transport, nuclear
is: SBO:0000185
product: MODEL1310110057#

metaR TRDR
is described by: ECO:0000269
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.8.1.9
name: thioredoxin reductase (NADPH)
kinetic law: MODEL1310110057#
fast: false
type: Reaction
modifier: MODEL1310110057#
is: SBO:0000176
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110057#_bd7aa678_335f_4041_b3fd_c84507f8ad18
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: _286297_1_c
boundary condition: true
constant: false
type: Species
is encoded by: hsa:286297
is: SBO:0000252

metaM adrncrn m
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: C00318
has only substance units: false
is: HMDB00062
name: Adrenyl carnitine
notes: FORMULA: C29H49NO4 CHARGE: 0
constant: false
is: CHEBI:16347
type: Species

metaM n2m2masn g
constant: false
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
initial concentration: 1.0
notes: FORMULA: C50H83N4O35X CHARGE: 0
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: C11530
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110057#_5aff3924_5ee7_4206_9df9_0bf4419a3466
initial concentration: NaN
is: P37837
is encoded by: hsa:6888
has only substance units: false
is: SBO:0000252
name: TALDO1
initial amount: NaN
type: Species
constant: false
boundary condition: true

metaM dhcholestancoa x
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
initial concentration: 1.0
boundary condition: false
is: CHEBI:15494
has only substance units: false
is: HMDB02159
is: SBO:0000247
constant: false
type: Species
initial amount: NaN

metaR OCOAT1m
type: Reaction
product: MODEL1310110057#
is: SBO:0000176
name: 3-oxoacid CoA-transferase
kinetic law: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/2.8.3.5
notes: GENE_ASSOCIATION: (5019.1) or (64064.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.8.3.5 Confidence Level: 4 AUTHORS: PMID:10964512,PMID:11756565 NOTES:TDV
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is described by: ECO:0000269
reversible: true

metaR RNDR2
kinetic law: MODEL1310110057#
reversible: false
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction
reactant: MODEL1310110057#
is: SBO:0000176
name: ribonucleoside-diphosphate reductase (GDP)
modifier: MODEL1310110057#
fast: false

metaR FAOXC12DCC10DCx
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12DC-->C10DC)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_5586a315_3c0d_4bff_b6e8_a8353cd77e27
type: Species
boundary condition: true
name: AK7
is: SBO:0000252
is: Q96M32
has only substance units: false
initial amount: NaN
is encoded by: hsa:122481
constant: false
initial concentration: NaN

metaM ile L m
is: CHEBI:17191
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: L-isoleucine
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: HMDB00172
is: SBO:0000247

metaR ACACT7p
fast: false
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
product: MODEL1310110057#
reactant: MODEL1310110057#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR BTNDm
reversible: false
name: biotinidase (biotin), mitochondrial
is version of: http://identifiers.org/ec-code/3.5.1.12
fast: false
reactant: MODEL1310110057#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
modifier: MODEL1310110057#
is: SBO:0000176

metaM cmp c
initial concentration: 1.0
initial amount: NaN
name: CMP
is: C00055
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
has only substance units: false
is: SBO:0000247
is: CHEBI:60377
is: HMDB00095
constant: false
type: Species
boundary condition: false

metaM co2 c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:3313
has only substance units: false
is: SBO:0000247
notes: FORMULA: CO2 CHARGE: 0
constant: false
type: Species
boundary condition: false
is: C00011
name: CO2
is: HMDB01967

metaR ADPACDAc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of adipic acid for formation of adipoyl carnitine
type: Reaction

metaR r0317
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.1.2.10
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.4.4.2
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
is: SBO:0000176
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.8.1.4
kinetic law: MODEL1310110057#

metaM ppi e
is: C00013
constant: false
name: Diphosphate
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00250
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: CHEBI:33019
boundary condition: false
initial amount: NaN

metaR CYTDtn
is described by: ECO:0000000
fast: false
reactant: MODEL1310110057#
is: SBO:0000185
product: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: cytidine transport in nucleus
type: Reaction
kinetic law: MODEL1310110057#

metaR RNDR1
is described by: ECO:0000254
modifier: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
name: ribonucleoside-diphosphate reductase (ADP)
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110057#
reversible: false

metaM lnlccoa c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
name: linoleic coenzyme A
type: Species
is: http://identifiers.org/pubchem.compound/5462164
boundary condition: false
is: HMDB01064
is: SBO:0000247
has only substance units: false
constant: false

metaM CE5118 m
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: CHEBI:57923
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110057#_387bab35_3932_4123_9771_3999fadf5185
name: PIGC
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5279
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
is: Q92535

http://identifiers.org/biomodels.db/MODEL1310110057#_9e1e9818_2cdd_4b75_823f_cf3be4e7f72f
is: SBO:0000252
name: B3GALNT1
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:8706
is: Q49AT3
initial concentration: NaN

metaM creat m
name: creatine
has only substance units: false
is: HMDB00064
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
constant: false
is: CHEBI:16919
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_931592f4_c49a_48e9_bc2b_ca85a9b13263
type: Species
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:AA526438
is: SBO:0000252
initial concentration: NaN
name: _AA526438_1_c
has only substance units: false

metaM co2 e
initial amount: NaN
is: CHEBI:16526
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB01967
name: CO2
type: Species
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: C00011
initial concentration: 1.0

metaM cmp e
initial amount: NaN
name: CMP(2-)
is: CHEBI:60377
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
has only substance units: false
type: Species
is: HMDB00095
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110057#_abe46a2a_ca70_445a_8f12_df1623987afb
has only substance units: false
is encoded by: hsa:4706
is: SBO:0000252
name: NDUFAB1
is: O14561
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species

metaM pi c
is: SBO:0000247
constant: false
initial concentration: 1.0
name: hydrogenphosphate
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2
is: C00009
is: HMDB00973
is: CHEBI:43474

metaR EX nac LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_5cec9ff1_f0c7_4057_82b7_8b4ceb7a92e4
is: Q6P1K9
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:80025
boundary condition: true
constant: false
initial concentration: NaN
name: PANK2

metaM dcmp c
initial concentration: 1.0
constant: false
is: HMDB01202
is: CHEBI:57566
type: Species
name: dCMP
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C00239
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
boundary condition: false

metaR FAOXC102C103m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaR r1836
fast: false
modifier: MODEL1310110057#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
name: Y+LAT2 Utilized transport

metaR r0456
type: Reaction
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.1.32
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110057#
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
is: SBO:0000176
reversible: false
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
fast: false
kinetic law: MODEL1310110057#

metaM cmp n
boundary condition: false
initial concentration: 1.0
is: CHEBI:60377
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
initial amount: NaN
name: CMP(2-)
type: Species
constant: false
has only substance units: false
is: HMDB00095

metaM h x
is: C00080
has only substance units: false
is: CHEBI:24636
initial concentration: 1.0
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
name: proton

metaR MACOXO
type: Reaction
notes: GENE_ASSOCIATION: (218.1) or (221.1) or (4129.1) or (222.1) or (220.1) SUBSYSTEM: Histidine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10344773 NOTES:SAB added 2 h to balance--not certain
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
product: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.4
reversible: false
name: 3-Methylimidazole acetaldehyde:NAD+ oxidoreductase
is: SBO:0000176
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000269

metaR SO4tl
type: Reaction
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
name: Sulfate transport (lysosome)
is described by: ECO:0000269
reactant: MODEL1310110057#
is: SBO:0000185
fast: false
product: MODEL1310110057#
reversible: true

metaR L LACt2r
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
kinetic law: MODEL1310110057#
name: L-lactate reversible transport via proton symport
fast: false
is: SBO:0000185
reactant: MODEL1310110057#
reversible: true
product: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_72bad0b2_372d_4567_aaf7_447290823aeb
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: A5JJ20
is: SBO:0000252
is encoded by: hsa:8671
name: SLC4A4
has only substance units: false
initial amount: NaN

metaM HC00250 c
initial concentration: 1.0
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial amount: NaN
has only substance units: false
is: CHEBI:29919
name: hydrosulfide
boundary condition: false
constant: false
type: Species
is: SBO:0000247

metaR r1552
reversible: true
product: MODEL1310110057#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM glx c
initial concentration: 1.0
has only substance units: false
name: glyoxylate
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
boundary condition: false
is: SBO:0000247
is: CHEBI:36655
initial amount: NaN
is: HMDB00119
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_97ffd8c7_a1f9_4856_8002_6c38cbb89909
name: UEVLD
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:55293
is: Q8IX04
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM xoltetrol m
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:17278
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
boundary condition: false
is: HMDB01231
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
is: SBO:0000247
initial amount: NaN
type: Species

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaM mi1p D n
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
name: 1D-myo-inositol 1-phosphate(2-)
is: CHEBI:58433
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB02985

metaR PDX5PO
name: pyridoxine 5'-phosphate oxidase
is: SBO:0000176
fast: false
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.4.3.5
product: MODEL1310110057#
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES:NCD
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_17e7b52d_89c6_4eb3_a920_bbb3a7a76e9e
is: SBO:0000252
boundary condition: true
has only substance units: false
name: PIGN
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:23556
type: Species

metaM ppi n
initial concentration: 1.0
name: diphosphate(3-)
is: HMDB00250
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:33019
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013

http://identifiers.org/biomodels.db/MODEL1310110057#_4d5f7b30_d871_456a_9008_8f24d090c6de
has only substance units: false
is: O00624
type: Species
constant: false
name: SLC17A2
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10246
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_057aa73a_225d_4dd0_bb2d_97d723e884a5
has only substance units: false
is encoded by: hsa:51
constant: false
boundary condition: true
name: ACOX1
is: B4DK61
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM HC02179 c
boundary condition: false
initial concentration: 1.0
name: 20-hydroxy-arachidonate
has only substance units: false
type: Species
constant: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial amount: NaN
is: CHEBI:34306
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_c8393c3c_eb39_4d70_9b14_3768f6c162a4
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q5JWV8
constant: false
boundary condition: true
is encoded by: hsa:2182
name: ACSL4

metaR HOCTDACBP
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyoctadecenoylcoa from mitochondria into the cytosol
type: Reaction

metaR r1551
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#
fast: false
is: SBO:0000185
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM tcynt c
has only substance units: false
initial amount: NaN
type: Species
constant: false
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: SBO:0000247
initial concentration: 1.0
name: thiocyanate
is: HMDB01453
is: CHEBI:18022
boundary condition: false

metaR DNDPt23m
kinetic law: MODEL1310110057#
name: dTDP transport via dGTP antiport
reversible: false
modifier: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185

metaR STS2
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110057#
reversible: false
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.6.2
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is: SBO:0000176
name: Steryl-sulfatase
product: MODEL1310110057#

metaR CITtbm
kinetic law: MODEL1310110057#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000185
type: Reaction
name: citrate transport, mitochondrial
fast: false
reversible: true
product: MODEL1310110057#

metaR NADtx
product: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
is: SBO:0000185
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: transport of NAD into peroxisome
reversible: true

metaM CE5868 e
has only substance units: false
type: Species
notes: FORMULA: C9H12N2O7 CHARGE: -2 INCHI: InChI=1/C9H14N2O7/c1-4(13)10-6(3-12)8(16)11-5(9(17)18)2-7(14)15/h5-6,12H,2-3H2,1H3,(H,10,13)(H,11,16)(H,14,15)(H,17,18)/p-2/t5-,6+/m1/s1 EHMN_ABBREVIATION: CE5868
initial concentration: 1.0
is: SBO:0000247
name: N-acetyl-seryl-aspartate
boundary condition: false
initial amount: NaN
is: HMDB02710
constant: false
is: CHEBI:27485

http://identifiers.org/biomodels.db/MODEL1310110057#_82a58c2d_cf47_4970_a0ab_dfabe20f58a5
constant: false
name: DGKD
is encoded by: hsa:8527
is: Q16760
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR FAOXC102C103x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)x
type: Reaction

metaR STS1
reversible: false
fast: false
kinetic law: MODEL1310110057#
is: SBO:0000176
name: Steryl-sulfatase
is described by: ECO:0000269
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.1.6.2
type: Reaction
product: MODEL1310110057#
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ

metaR r1554
reversible: true
product: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110057#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110057#
type: Reaction

metaR RE3004M
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000000
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE3004
modifier: MODEL1310110057#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110057#_bc100d17_a0b7_40f1_ad63_d9ed9917879b
name: NDUFA12
initial concentration: NaN
has only substance units: false
is encoded by: hsa:55967
is: SBO:0000252
type: Species
is: F8VQS7
boundary condition: true
initial amount: NaN
constant: false

metaR C10OHc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdecanoylcarnitinec
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_64d6fffb_564f_4a90_a361_53780ff4bbb6
is encoded by: hsa:518
type: Species
is encoded by: hsa:515
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
constant: false
is encoded by: hsa:10476
has part: P18859
has part: P24539
boundary condition: true
is encoded by: hsa:522
is: SBO:0000297
initial concentration: NaN
has only substance units: false
has part: O75947

metaR 5OXPROt
name: Transport of 5-oxoprolinate
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110057#
type: Reaction
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#

metaM tmndnccoa m
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
type: Species
name: timnodonyl coenzyme A
initial concentration: 1.0
has only substance units: false
is: HMDB06514
boundary condition: false

metaM HC01115 c
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
name: NeuNGc
is: CHEBI:29025
is: SBO:0000247
boundary condition: false

metaR C4DCCACT
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinyl carnitine into cytosol
type: Reaction

metaR UMPK7n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reactant: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
fast: false
name: UMP kinase (dGTP),nuclear
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110057#
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR G14T18g
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110057#
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110057#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reactant: MODEL1310110057#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110057#

metaM HC02179 e
type: Species
name: 20-hydroxy-arachidonate
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial amount: NaN
constant: false
is: CHEBI:34306

metaR UGLCNACtg
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
name: UDP-GlcNAc Golgi transport via CMP antiport
reactant: MODEL1310110057#
is: SBO:0000185
fast: false
reversible: true
type: Reaction
is described by: ECO:0000269

metaM nad c
constant: false
is: http://identifiers.org/pubchem.compound/3305
boundary condition: false
is: CHEBI:57540
has only substance units: false
is: SBO:0000247
is: HMDB00902
name: Nicotinamide adenine dinucleotide
is: C00003
type: Species
initial concentration: 1.0
initial amount: NaN

metaR CHAT
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
type: Reaction
product: MODEL1310110057#
name: Choline O-acetyltransferase
modifier: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.6
reversible: true
kinetic law: MODEL1310110057#

metaM 2octdectecoa x
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
name: 2,6,9,12-octadecatetraenoylcoa
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/5280355

metaM dolglcp L r
constant: false
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
is: CHEBI:15812
initial concentration: 1.0
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
is: SBO:0000247
initial amount: NaN

metaR r1553
is described by: ECO:0000000
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
reactant: MODEL1310110057#

metaR GBSIDEte
kinetic law: MODEL1310110057#
name: globoside transport
is described by: ECO:0000000
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - The goal of this transporter is to get globoside to the EC plasma membrane NJ
reversible: true
fast: false
reactant: MODEL1310110057#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110057#_a0646fd0_b8fc_48dc_9757_c1e65fe7684e
type: Species
has only substance units: false
is encoded by: hsa:29920
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q96C36
name: PYCR2
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_a9e37273_a382_4968_980c_b38dff6eb8f3
has only substance units: false
type: Species
is encoded by: hsa:3418
name: IDH2
constant: false
is: P48735
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR r1556
reactant: MODEL1310110057#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110057#
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110057#

metaM 7dhchsterol c
type: Species
initial amount: NaN
is: CHEBI:17759
has only substance units: false
name: cholesta-5,7-dien-3beta-ol
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
is: HMDB00032
constant: false
boundary condition: false
initial concentration: 1.0

metaR GACPAILter
kinetic law: MODEL1310110057#
reversible: false
product: MODEL1310110057#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
name: glucosaminyl-acylphosphatidylinositol ER flippase
is described by: ECO:0000000

metaR ASCBt4
fast: false
modifier: MODEL1310110057#
reversible: true
name: L-ascorbate transport via proton symport
kinetic law: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_e4382006_a620_4501_88f5_51e8602715c9
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:2974
name: GUCY1B2
boundary condition: true
initial amount: NaN

metaM ksii core4 pre3 g
is: HMDB00175
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 3
is: CHEBI:58053
is: C00130
constant: false
notes: FORMULA: C55H89N5O38X CHARGE: -1
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_5bd39fb6_4f31_445b_9c57_5498562c15fb
is: Q9NPH0
has only substance units: false
name: ACP6
is encoded by: hsa:51205
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false

metaR r0311
is described by: ECO:0000000
fast: false
reactant: MODEL1310110057#
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
reversible: false
modifier: MODEL1310110057#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.3.1.9
is: SBO:0000176
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaR IPDDIx
modifier: MODEL1310110057#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.3.2
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
name: isopentenyl-diphosphate D-isomerase
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
reversible: true
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110057#_f4ab6303_ee2a_4928_a152_b93b7e34b8a5
is encoded by: hsa:51
type: Species
is: B4DK61
constant: false
name: ACOX1
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM chol c
initial concentration: 1.0
name: Choline
is: HMDB00097
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
boundary condition: false
constant: false
type: Species
is: C00114
is: CHEBI:15354

metaR B3GNT312g
reversible: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
type: Reaction
product: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
is described by: ECO:0000254
reactant: MODEL1310110057#
is: SBO:0000176
modifier: MODEL1310110057#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaR G14T5g
modifier: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is: SBO:0000176
kinetic law: MODEL1310110057#
product: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
reversible: false

metaR r0758
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is: SBO:0000176
reactant: MODEL1310110057#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.16
product: MODEL1310110057#
is described by: ECO:0000000
name: 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase Tryptophan metabolism EC:1.2.1.3
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:8155713,PMID:8605195 NOTES:
fast: false

metaR ADEt
reversible: true
reactant: MODEL1310110057#
name: adenine reversible transport, cytosol
modifier: MODEL1310110057#
is: SBO:0000185
fast: false
product: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
is described by: ECO:0000269

metaM 3decdicoa x
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/16019966
name: 3,7-decadienoylcoa
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM ppi m
name: Diphosphate
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0
boundary condition: false
type: Species
is: C00013
has only substance units: false
is: CHEBI:33019
is: SBO:0000247
initial amount: NaN
is: HMDB00250
constant: false

metaM core3 g
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: SBO:0000247
has only substance units: false
is: CHEBI:16250
name: Core 3

metaR EX dag hs LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for diglyceride
type: Reaction

metaM c4dc x
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB02013
name: succinyl carnitine
notes: FORMULA: C11H18NO6 CHARGE: -1
is: http://identifiers.org/pubchem.compound/213144
is: C02862
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_19dc0dd4_117a_4772_a2c1_e93560babd75
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8140
constant: false
name: SLC3A2:SLC7A5
has only substance units: false
type: Species
has part: Q8IV97
is: SBO:0000297
initial amount: NaN

metaR BTNDe
reactant: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110057#
name: biotinidase (biotin), extracellular
reversible: false
fast: false
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT
type: Reaction
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.5.1.12

metaR r0450
fast: false
reversible: true
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000000
reactant: MODEL1310110057#
type: Reaction
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.3
modifier: MODEL1310110057#

metaM btcoa c
constant: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
is: CHEBI:57371
is: HMDB01088
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: Butanoyl-CoA
is: C00136

metaR EX hpdca LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptadecanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_f16eaa95_8b5d_471e_9bcc_c4529a41e31d
initial amount: NaN
constant: false
has part: P10619
has only substance units: false
is: SBO:0000297
name: GALNS:GLB1:NEU1:CTSA
initial concentration: NaN
has part: P34059
has part: Q99519
is encoded by: hsa:5476
has part: P16278
is encoded by: hsa:2720
is encoded by: hsa:4758
is encoded by: hsa:2588
type: Species
boundary condition: true

metaM od2coa m
type: Species
constant: false
boundary condition: false
is: SBO:0000247
name: trans-Octadec-2-enoyl-CoA
is: HMDB06529
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h18-19,26-28,32-34,38,49-50H,4-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b19-18+/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE2244
is: CHEBI:50570
initial concentration: 1.0
initial amount: NaN

metaR ILEt5m
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
name: Isoleucine mitochondrial transport
fast: false
reactant: MODEL1310110057#
product: MODEL1310110057#
type: Reaction

metaM HC00250 e
has only substance units: false
initial amount: NaN
is: CHEBI:29919
name: hydrosulfide
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
type: Species
constant: false

metaR RE1521M
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000000
reactant: MODEL1310110057#
name: RE1521
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
product: MODEL1310110057#
fast: false
type: Reaction

metaR EX chtn LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chitin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_dbebce5a_8740_4372_9c1c_6633d4df0d1d
is: SBO:0000252
name: COASY
has only substance units: false
initial amount: NaN
is encoded by: hsa:80347
boundary condition: true
constant: false
is: Q13057
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_ed0c2dae_fc3d_4af6_a722_096bf42fc87e
name: _AA021081_1_r
initial concentration: NaN
is encoded by: hsa:AA021081
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false

metaR r1557
reversible: true
product: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000185

metaM co2 m
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
has only substance units: false
is: HMDB01967
constant: false
type: Species
name: CO2
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: C00011
is: CHEBI:16526

http://identifiers.org/biomodels.db/MODEL1310110057#_94e37e65_96a3_4c94_a03d_708a56a80d11
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
name: CA9
initial amount: NaN
boundary condition: true
is: Q16790
is encoded by: hsa:768
constant: false

metaR ETOHt
product: MODEL1310110057#
fast: false
reversible: true
kinetic law: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD
reactant: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000000
name: ethanol reversible transport

http://identifiers.org/biomodels.db/MODEL1310110057#_08774edd_d615_4370_b08d_e79bf37478ed
initial concentration: NaN
constant: false
is encoded by: hsa:55276
type: Species
is: SBO:0000252
name: PGM2
has only substance units: false
is: Q96G03
initial amount: NaN
boundary condition: true

metaR BILDGLCURtr
name: glucuronidated compound transport
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
kinetic law: MODEL1310110057#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110057#
type: Reaction
fast: false

metaM chol e
initial concentration: 1.0
name: Choline
initial amount: NaN
is: SBO:0000247
is: HMDB00097
has only substance units: false
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
is: C00114
type: Species
boundary condition: false
is: CHEBI:15354

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_c406b336_6186_450e_9188_43e76be52255
name: HSD17B10
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q99714
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:3028

metaM tcynt e
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: SBO:0000247
is: HMDB01453
initial concentration: 1.0
is: CHEBI:18022
name: thiocyanate
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_a3ea992e_97f2_4959_81e8_16b27885ae20
type: Species
initial concentration: NaN
is encoded by: hsa:66035
constant: false
has only substance units: false
is: Q8WXF9
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: SLC2A11

metaR SFGTH
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.2.12
reversible: true
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
name: S-Formylglutathione hydralase
kinetic law: MODEL1310110057#
fast: false
modifier: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#

metaM pan4p m
has only substance units: false
boundary condition: false
is: CHEBI:47942
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: SBO:0000247
type: Species
name: pantetheine 4'-phosphate(2-)
is: HMDB01416

metaR ACACt2m
name: Acetoacetate mitochondrial transport via H+ symport
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
product: MODEL1310110057#
reactant: MODEL1310110057#
modifier: MODEL1310110057#
reversible: true

metaM CE2431 m
boundary condition: false
has only substance units: false
name: cis-deca-4-enoyl-CoA
type: Species
is: CHEBI:57795
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431

metaR TMDPK
fast: false
type: Reaction
modifier: MODEL1310110057#
reactant: MODEL1310110057#
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.6.2
kinetic law: MODEL1310110057#
reversible: false

metaM ak2lgchol hs c
boundary condition: false
constant: false
has only substance units: false
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
initial concentration: 1.0
initial amount: NaN
is: C04317
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/6975
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317

http://identifiers.org/biomodels.db/MODEL1310110057#_39239ee0_db0b_40b5_a93f_c12865a6f941
is encoded by: hsa:1593
boundary condition: true
name: CYP27A1
constant: false
initial amount: NaN
type: Species
is: Q02318
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM pi m
name: hydrogenphosphate
is: C00009
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: CHEBI:43474
is: HMDB00973
boundary condition: false

metaR NDPK7
name: nucleoside-diphosphate kinase (ATP:dCDP)
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110057#
is described by: ECO:0000269
is: SBO:0000176

metaM 3pg c
boundary condition: false
initial amount: NaN
name: 3-Phospho-D-glycerate
is: C00197
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3497
is: CHEBI:58272
has only substance units: false
is: HMDB00807

metaR C101CRNe
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decenoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_7431f243_d99d_4d19_9701_3a541f4acfa8
has only substance units: false
initial amount: NaN
boundary condition: true
name: _AI285872_1_c
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:AI285872
type: Species

metaR CYTK14
name: cytidylate kinase (dCMP,UTP)
is described by: ECO:0000269
reversible: true
type: Reaction
fast: false
product: MODEL1310110057#
is: SBO:0000176
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_8f2e4dfb_31bb_44aa_b0c7_7313b04e0fa2
is: P18283
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:2877
name: GPX2
initial concentration: NaN
type: Species
has only substance units: false

metaR r0754
product: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000176
modifier: MODEL1310110057#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reversible: true

metaR NDPK8
is: SBO:0000176
modifier: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110057#
type: Reaction
is described by: ECO:0000269
name: Nucleoside-diphosphate kinase (ATP:dADP)
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110057#

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

metaM omhpal c
notes: FORMULA: C16H30O3 CHARGE: -1
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
name: w-hydroxypalmiticacid
constant: false
is: HMDB06294

metaR FAOXC15ATPx
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C15)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_32c5b8fe_bcbb_4fa8_b3a6_ef0db89a1aac
has only substance units: false
is encoded by: hsa:123041
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q8NFF2
type: Species
is: SBO:0000252
name: SLC24A4
constant: false

metaM CE2416 x
name: (2R,6S,10S)-pristanate
has only substance units: false
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)/p-1/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: CE2416
is: CHEBI:57923
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247

metaR FAOXC1811602m
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
kinetic law: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
reactant: MODEL1310110057#
name: Beta oxidation fatty acid
fast: false
modifier: MODEL1310110057#
type: Reaction

metaR NDPK6
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
reactant: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Nucleoside-diphosphate kinase (ATP:dUDP)
reversible: true
type: Reaction
product: MODEL1310110057#
is described by: ECO:0000269
modifier: MODEL1310110057#

metaR PCm
type: Reaction
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/6.4.1.1
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
name: pyruvate carboxylase
product: MODEL1310110057#
fast: false
reversible: false

metaR r0191
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.2.1.24
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
type: Reaction
is: SBO:0000176
modifier: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
reversible: false

metaR CYTK13
name: cytidylate kinase (dCMP,dATP)
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
type: Reaction
kinetic law: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110057#
fast: false
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_5962f17f_e90d_48ea_b81c_34de4ba91279
is encoded by: hsa:6526
type: Species
is: P53794
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: SLC5A3
has only substance units: false

metaM m4mpdol L c
constant: false
is: CHEBI:37633
boundary condition: false
type: Species
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM dgpi prot hs r
type: Species
boundary condition: false
is: HMDB02925
is: CHEBI:53486
notes: FORMULA: C39H76N4O37P4FULLRCO2FULLR2CO2X CHARGE: 0
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
name: deacylated-glycophosphatidylinositol (GPI)-anchored protein

metaM gam e
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
name: D-Glucosamine
is: SBO:0000247
is: CHEBI:17315
is: HMDB01514
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: C00329

metaR r0753
reactant: MODEL1310110057#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110057#
is: SBO:0000176
modifier: MODEL1310110057#
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
product: MODEL1310110057#
type: Reaction

metaM pail5p hs c
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: CHEBI:57795
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR r2535
product: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_c81e1507_cf92_4870_b194_1e49811b582e
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: P07205
is encoded by: hsa:5232
name: PGK2
initial amount: NaN
type: Species
boundary condition: true

metaM lnlccoa m
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5462164
type: Species
is: HMDB01064
name: linoleic coenzyme A
has only substance units: false
boundary condition: false

metaM estrone c
has only substance units: false
notes: FORMULA: C18H22O2 CHARGE: 0 INCHI: InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1 EHMN_ABBREVIATION: C00468
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00145
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:17263
name: estrone

metaR C12OHc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdodecanoylcarnitinec
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_9e8aecc6_9e95_4054_b615_c3f0703283d0
initial concentration: NaN
type: Species
name: EHHADH
is: Q9NY65
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1962

metaR CYTK12
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110057#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is described by: ECO:0000269
name: cytidylate kinase (dCMP,dCTP)

http://identifiers.org/biomodels.db/MODEL1310110057#_4fa6d5bd_7658_4684_9a1f_bf4b0cc58b0b
initial concentration: NaN
is: SBO:0000252
constant: false
name: NDUFB2
is: H7C5B8
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:4708
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_metaR_EX_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_6e6eecf7_c214_4b4f_8ef5_7ddf1da0936d
initial amount: NaN
has part: O15254
is: SBO:0000297
type: Species
name: EHHADH:ACAA1:HSD17B4:ACOX3
boundary condition: true
has only substance units: false
initial concentration: NaN
has part: Q9NY65
is encoded by: hsa:1962
constant: false
is encoded by: hsa:8310

metaR RE0937E
name: RE0937
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.17.23
notes: GENE_ASSOCIATION: (59272.1) SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 0 AUTHORS: PMID:10969042,PMID:11815627 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110057#
reversible: true
modifier: MODEL1310110057#
is: SBO:0000176
fast: false
product: MODEL1310110057#
kinetic law: MODEL1310110057#

metaR METtec
reactant: MODEL1310110057#
is: SBO:0000185
fast: false
product: MODEL1310110057#
name: L-methionine transport via diffusion (extracellular to cytosol)
reversible: true
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
type: Reaction
modifier: MODEL1310110057#
is described by: ECO:0000269

metaR ACNAMlt
reactant: MODEL1310110057#
type: Reaction
reversible: true
kinetic law: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
name: N-acetylneuraminate transport into lysososme
fast: false
is described by: ECO:0000269
modifier: MODEL1310110057#
product: MODEL1310110057#

metaM 11 cis retfa e
boundary condition: false
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
is: HMDB00972
is: CHEBI:57454
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
name: fatty acid 11-cis-retinol
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_b9a5e405_4292_4672_9f52_7f59f44693f2
name: SLC16A3
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9123
constant: false
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: O15427

metaM ksi deg27 l
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
name: keratan sulfate I, degradation product 27
is: CHEBI:12936
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110057#_abd46b47_436a_46da_bf93_410da6009842
type: Species
is: SBO:0000252
name: PLA2G2E
is encoded by: hsa:30814
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q9NZK7

metaM 3decdicoa m
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species
name: 3,7-decadienoylcoa

metaM xan c
boundary condition: false
constant: false
has only substance units: false
name: Xanthine
initial concentration: 1.0
is: HMDB00292
type: Species
is: CHEBI:17712
initial amount: NaN
is: C00385
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_37e978c8_69a6_471a_84d6_56395428e5a9
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
name: PIGO
boundary condition: true
is: Q8TEQ8
is encoded by: hsa:84720

metaR r0193
reversible: true
product: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
is: SBO:0000176
reactant: MODEL1310110057#
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
is described by: ECO:0000000
fast: false

metaM 2dp6mobq me m
type: Species
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C58H88O3 CHARGE: 0 INCHI: InChI=1S/C58H88O3/c1-44(2)23-14-24-45(3)25-15-26-46(4)27-16-28-47(5)29-17-30-48(6)31-18-32-49(7)33-19-34-50(8)35-20-36-51(9)37-21-38-52(10)39-22-40-53(11)41-42-55-54(12)56(59)43-57(61-13)58(55)60/h23,25,27,29,31,33,35,37,39,41,43H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+,53-41+
initial concentration: 1.0
is: CHEBI:50772
is: SBO:0000247
initial amount: NaN
name: 2-decaprenyl-6-methoxy-3-methyl-1,4-benzoquinone

metaR KYNAKGAT
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.7
is: SBO:0000176
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
reactant: MODEL1310110057#
name: L-Kynurenine:2-oxoglutarate aminotransferase
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.6.1.64
is described by: ECO:0000269
reversible: false
product: MODEL1310110057#
type: Reaction
modifier: MODEL1310110057#

metaM pi n
has only substance units: false
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: SBO:0000247
is: HMDB00973
is: CHEBI:43474
boundary condition: false
initial amount: NaN
constant: false
name: hydrogenphosphate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_6562be96_9117_4f2b_bd3f_a22d5bce2355
is: SBO:0000252
initial amount: NaN
name: _LOC728997_1_c
initial concentration: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:LOC728997

metaR r2537
is: SBO:0000185
product: MODEL1310110057#
is described by: ECO:0000000
reactant: MODEL1310110057#
reversible: true
fast: false
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
kinetic law: MODEL1310110057#

metaR r0755
fast: false
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reversible: true
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000000

metaR CYTK11
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dGTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110057#
reversible: true
kinetic law: MODEL1310110057#
is: SBO:0000176
reactant: MODEL1310110057#
product: MODEL1310110057#

metaR NDPK9
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
reversible: true
kinetic law: MODEL1310110057#
type: Reaction
name: nucleoside-diphosphate kinase (ATP:IDP)
reactant: MODEL1310110057#
fast: false
is: SBO:0000176
product: MODEL1310110057#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM gam c
is: C00329
initial concentration: 1.0
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
name: D-Glucosamine
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:17315
boundary condition: false
type: Species
is: HMDB01514

http://identifiers.org/biomodels.db/MODEL1310110057#_2f20488c_012d_43ec_a3cd_748a0a186e8a
is: SBO:0000252
constant: false
is encoded by: hsa:F23536
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: _F23536_1_m

metaM chol r
is: CHEBI:15354
initial amount: NaN
name: choline
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: HMDB00097
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
has only substance units: false

metaR RE3245C
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110057#
product: MODEL1310110057#
name: RE3245
reversible: true
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_4fe2b7ef_933e_4ad4_8ebd_07a23de0e676
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:1607
boundary condition: true
name: DGKB

metaR r2532
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110057#
fast: false
product: MODEL1310110057#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110057#
reversible: true
is: SBO:0000185
type: Reaction

metaR r0750
product: MODEL1310110057#
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
is: SBO:0000176
reversible: true
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110057#
fast: false

metaR CYOR u10m
reversible: false
fast: false
is described by: ECO:0000134
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
name: ubiquinol-6 cytochrome c reductase, Complex III
kinetic law: MODEL1310110057#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.92
is: SBO:0000185
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.2.1.3

metaR NDPK3
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
name: nucleoside-diphosphate kinase (ATP:CDP)
modifier: MODEL1310110057#
reactant: MODEL1310110057#
reversible: true
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000269

metaR EICOSTETt
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
is: SBO:0000185
reactant: MODEL1310110057#
fast: false
product: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#
reversible: true

metaR r0196
type: Reaction
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
product: MODEL1310110057#
fast: false
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.6.1.5

http://identifiers.org/biomodels.db/MODEL1310110057#_92d4afda_5379_4b9d_910a_1d337ccf6ceb
initial amount: NaN
name: DGKD
constant: false
is encoded by: hsa:8527
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

metaM pheacgln c
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
is: SBO:0000247
type: Species
constant: false
is: HMDB06344
has only substance units: false
boundary condition: false
is: CHEBI:58310
initial amount: NaN
initial concentration: 1.0

metaR DLNLCGCRNt
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110057#
name: transport into the mitochondria (carnitine)
reversible: false
reactant: MODEL1310110057#
fast: false
modifier: MODEL1310110057#
is described by: ECO:0000000
product: MODEL1310110057#
type: Reaction

metaM 56dthm c
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
name: 5,6-dihydrothymine
type: Species
is: HMDB00079
is: CHEBI:27468
is: SBO:0000247
boundary condition: false

metaR DOLPGT2 Ler
reversible: false
reactant: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is described by: ECO:0000000
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.265
modifier: MODEL1310110057#
is: SBO:0000176
type: Reaction
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
product: MODEL1310110057#

metaM dolglcp L c
has only substance units: false
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
initial concentration: 1.0
is: CHEBI:15812
initial amount: NaN
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110057#_5d1b49fb_1fac_47c7_923d_af5e7274e49c
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4700
type: Species
constant: false
initial concentration: NaN
is: P56556
has only substance units: false
initial amount: NaN
name: NDUFA6

metaR GLYt7 311 r
fast: false
reactant: MODEL1310110057#
reversible: true
name: glycine reversible transport via sodium and chloride symport (3:1:1)
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
product: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
is described by: ECO:0000006

http://identifiers.org/biomodels.db/MODEL1310110057#_23501c2b_4277_4cd9_a66a_d80f440c0504
initial amount: NaN
initial concentration: NaN
name: ACE2
boundary condition: true
is: C7ECU1
has only substance units: false
type: Species
is encoded by: hsa:59272
is: SBO:0000252
constant: false

metaR NDPK2
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110057#
name: nucleoside-diphosphate kinase (ATP:UDP)
is: SBO:0000176
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110057#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR r1560
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110057#
reversible: true
product: MODEL1310110057#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_6004514b_d587_4d42_a3bd_facc760e2bdd
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI191472
name: _AI191472_1_c
is: SBO:0000252
type: Species
initial amount: NaN
constant: false

metaM od2coa c
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244
boundary condition: false
is: HMDB06529
is: CHEBI:50570
type: Species
initial concentration: 1.0
name: trans-Octadec-2-enoyl-CoA
is: SBO:0000247
is: C16218

metaM sebacid x
boundary condition: false
is: HMDB00792
is: C08277
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C10H16O4 CHARGE: -2
initial amount: NaN
is: SBO:0000247
name: sebacicacid
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_1c889701_bd7a_435c_9a78_f4bee4763799
is: Q9H008
has only substance units: false
type: Species
name: LHPP
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:64077
initial amount: NaN
boundary condition: true

metaR RE1898C
reversible: true
type: Reaction
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
reactant: MODEL1310110057#
is: SBO:0000176
fast: false
name: RE1898
product: MODEL1310110057#
is described by: ECO:0000000

metaM core2 g
name: Core 2
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:15876
notes: FORMULA: C22H37N2O15X CHARGE: 0
initial amount: NaN

metaR NDPK5
is described by: ECO:0000269
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
name: Nucleoside-diphosphate kinase (ATP:dGDP)
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000176

metaR r0752
modifier: MODEL1310110057#
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110057#

metaR r2534
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000

metaR M16NTg
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
is: SBO:0000176
reactant: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
modifier: MODEL1310110057#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.143
type: Reaction
kinetic law: MODEL1310110057#
is described by: ECO:0000000
product: MODEL1310110057#

metaR r1561
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
fast: false

metaM pheacgln e
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
constant: false
type: Species
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
is: HMDB06344
initial amount: NaN
is: CHEBI:58310
boundary condition: false
has only substance units: false

metaR CHOLD2m
modifier: MODEL1310110057#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.99.1
notes: GENE_ASSOCIATION: (55349.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.99.1 Confidence Level: 4 AUTHORS: PMID:15321791 NOTES:
product: MODEL1310110057#
name: choline dehydrogenase (FAD acceptor), mitochondrial
is described by: ECO:0000269
reactant: MODEL1310110057#
is: SBO:0000176
kinetic law: MODEL1310110057#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110057#_670186cf_be9f_49ea_b3e0_ff7e7dbee206
is encoded by: hsa:1716
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: DGUOK

metaM chol m
name: choline
is: CHEBI:15354
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial amount: NaN
is: HMDB00097

metaM tcynt m
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: thiocyanate
constant: false
is: CHEBI:18022
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: HMDB01453
has only substance units: false

metaR FUMtm
is described by: ECO:0000269
name: fumarate transport, mitochondrial
reversible: true
modifier: MODEL1310110057#
product: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#

metaR LTC4CP
reactant: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
reversible: true
is described by: ECO:0000000
product: MODEL1310110057#
name: Leukotriene C4 carboxypeptidase
fast: false
kinetic law: MODEL1310110057#
is: SBO:0000176

metaM acac m
is: CHEBI:13705
has only substance units: false
is: SBO:0000247
name: acetoacetate
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: HMDB00060
type: Species
constant: false

metaM pi r
has only substance units: false
is: CHEBI:43474
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: hydrogenphosphate
is: HMDB00973
is: C00009
constant: false
type: Species

metaM 13dampp c
initial concentration: 1.0
type: Species
is: CHEBI:57484
name: trimethylenediaminium
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00002
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

metaR NDPK4
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reversible: true
reactant: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
name: nucleoside-diphosphate kinase (ATP:dTDP)
is described by: ECO:0000269
modifier: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_a61d489e_2341_47f8_8127_da0de17cfd1c
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3420
is: SBO:0000252
constant: false
name: IDH3B

metaR r1562
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
product: MODEL1310110057#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110057#_8dfe8b10_96e4_485b_82f0_ac1b1a206bde
is encoded by: hsa:83715
is: B1AK53
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
name: ESPN

metaM chol n
initial concentration: 1.0
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
type: Species
name: choline
constant: false
is: CHEBI:15354
boundary condition: false
initial amount: NaN
is: HMDB00097
has only substance units: false
is: SBO:0000247

metaM pi e
has only substance units: false
constant: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
name: hydrogenphosphate
is: C00009
initial concentration: 1.0
is: HMDB00973
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247

metaR PROSTGI2t
name: Prostaglandin I2 transport
is: SBO:0000185
kinetic law: MODEL1310110057#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_7f83e80d_b11b_4049_af2e_2152c4d9177d
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: O95395
is: SBO:0000252
constant: false
name: GCNT3
type: Species
boundary condition: true
is encoded by: hsa:9245

metaM ahcys m
name: S-Adenosyl-L-homocysteine
is: C00021
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00939
has only substance units: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
constant: false
is: CHEBI:16680

metaR FUCASE2e
is version of: http://identifiers.org/ec-code/3.2.1.51
modifier: MODEL1310110057#
name: alpha-fucosidase, extracellular
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:10460218,PMID:11389735,PMID:12604617,PMID:2317201 NOTES:NCD
kinetic law: MODEL1310110057#
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110057#_1cbd8f0e_4e00_49fb_a7e1_1116e83ea686
initial concentration: NaN
name: AMPD2
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:271
has only substance units: false
is: E9PNG0
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_1aa26b63_5531_4608_9fc8_5d4bb27934f8
has only substance units: false
is: P50993
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
name: ATP1A2
is encoded by: hsa:477

http://identifiers.org/biomodels.db/MODEL1310110057#_025abe48_760f_4288_a867_a92079cec964
is encoded by: hsa:113451
is: SBO:0000252
type: Species
constant: false
is: Q96A70
name: ADC
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_61e9fc9d_d5ce_434c_9e35_1dd770aaa3e1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1892
boundary condition: true
constant: false
name: ECHS1
initial amount: NaN
type: Species
is: P30084

metaR FUMAC
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.7.1.2
reactant: MODEL1310110057#
name: fumarylacetoacetase
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110057#
fast: false
reversible: false
modifier: MODEL1310110057#
product: MODEL1310110057#

metaR BALABETAtc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of beta alanine into the intestinal cells by beta transport system
type: Reaction

metaR P4501B1r
notes: GENE_ASSOCIATION: (1545.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:8910454 NOTES:_4 hydroxylation of 17 beta estradiol NJ
modifier: MODEL1310110057#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.14.1
fast: false
kinetic law: MODEL1310110057#
reversible: false
reactant: MODEL1310110057#
name: cytochrome P450 1B1
is: SBO:0000176
product: MODEL1310110057#

metaM camp c
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
has only substance units: false
name: 3',5'-cyclic AMP(1-)
is: HMDB00058
is: CHEBI:58165
initial amount: NaN
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110057#_67c477c5_86d6_4b40_9af3_7aaad4176295
has only substance units: false
type: Species
constant: false
name: NDUFV1
initial amount: NaN
is: E5KNH5
is encoded by: hsa:4723
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR PCt
is described by: ECO:0000269
product: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ
is: SBO:0000185
kinetic law: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
name: phosphatidylcholine transporter
is version of: http://identifiers.org/ec-code/3.6.3.44
modifier: MODEL1310110057#
reversible: true

metaR EX glyb LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycine betaine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_70ebf4a8_5404_4107_9169_782bffd360b7
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: FOLR1
is encoded by: hsa:2348
initial concentration: NaN
constant: false
boundary condition: true

metaR PIt7
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
type: Reaction
fast: false
modifier: MODEL1310110057#
name: phosphate transport in/out via three Na+ symporter
reversible: true
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is: SBO:0000185

metaM din e
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00071
name: Deoxyinosine
is: C05512
is: CHEBI:28997
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_d9192713_1028_45b6_a8cb_bfec930b1ca5
constant: false
is: B2RB47
has only substance units: false
initial amount: NaN
is encoded by: hsa:271
name: AMPD2
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN

metaM pan4p e
type: Species
name: Pantetheine 4'-phosphate
is: C01134
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: SBO:0000247
has only substance units: false
is: CHEBI:47942
initial amount: NaN
constant: false
is: HMDB01416
initial concentration: 1.0
boundary condition: false

metaM creat c
is: CHEBI:16919
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00064
initial concentration: 1.0
constant: false
name: creatine
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110057#_f15fdb77_51e8_4a23_8cbd_78cfa760fa6a
has only substance units: false
boundary condition: true
is encoded by: hsa:50484
initial amount: NaN
is: Q7LG56
name: RRM2B
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN

metaR FAOXC18480m
kinetic law: MODEL1310110057#
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110057#
reversible: false
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110057#_9b19c35b_57f0_4be2_b1a4_428882bc8d06
initial amount: NaN
name: CA4
is: Q6FHI7
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:762
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_2011b455_a06a_49dd_8ef6_dc2d0c99d70b
initial concentration: NaN
constant: false
boundary condition: true
is: Q53YB7
is encoded by: hsa:1329
initial amount: NaN
is: SBO:0000252
name: COX5B
has only substance units: false
type: Species

metaR r1164
name: EC:2.3.1.26
fast: false
product: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110057#
type: Reaction
reversible: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:

metaR NDP7g
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
modifier: MODEL1310110057#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
name: nucleoside-diphosphatase (UDP), Golgi apparatus
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.6.1.6
type: Reaction
reversible: false
is described by: ECO:0000269

metaM arachcrn c
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
name: arachidyl carnitine
type: Species
is: HMDB06460
boundary condition: false
initial concentration: 1.0
constant: false

metaR ACOX22x
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 2 AUTHORS: PMID:11181649 NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 analog as per KEGG added NJ
modifier: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
is described by: ECO:0000304
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.99.3
reversible: false
type: Reaction
name: acyl-Coenzyme A oxidase 2, branched chain

metaM 3hexdtetcoa x
boundary condition: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: HMDB02288
name: 3,7,10,13-hexadecatetraenoylcoa

metaM 3octdeccrn e
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C25H49NO5 CHARGE: 0
initial concentration: 1.0
type: Species
name: 3-hydroxyoctadecanoyl carnitine
is: SBO:0000247
boundary condition: false
is: HMDB13336

metaR FAOXTC122m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization trans(C12:2)m
type: Reaction

metaM pail34p hs c
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:57658
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
constant: false
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)

metaR G6PDH2rer
is described by: ECO:0000269
kinetic law: MODEL1310110057#
is: SBO:0000176
reactant: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.47
modifier: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
type: Reaction
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_85e90e52_e938_47e0_a060_bbe7a1f0b87d
is: SBO:0000297
type: Species
initial amount: NaN
is encoded by: hsa:5291
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:5295
has part: B4DER4
has part: B3KT19
name: PIK3CB:PIK3R1
initial concentration: NaN

metaR FAOXC18C18OHm
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18-->C18OH)m
type: Reaction

metaR FAOXC61m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaM pi g
is: CHEBI:43474
has only substance units: false
name: hydrogenphosphate
is: HMDB00973
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

http://identifiers.org/biomodels.db/MODEL1310110057#_6f21ffae_0799_40b4_b0f3_58792ec66ac1
is: SBO:0000252
is: P57054
name: PIGP
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:51227
initial concentration: NaN
initial amount: NaN
type: Species

metaR NACHEXA20ly
modifier: MODEL1310110057#
is described by: ECO:0000000
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
kinetic law: MODEL1310110057#
reversible: false
name: beta-N-acetylhexosaminidase A, lysosomal
type: Reaction
is: SBO:0000176

metaM pail5p hs n
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: CHEBI:57795
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_a2bbc36f_32da_4957_8780_99c41887b266
constant: false
initial amount: NaN
has only substance units: false
is: P00390
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: GSR
is encoded by: hsa:2936

http://identifiers.org/biomodels.db/MODEL1310110057#_be3bf6a6_c2e7_442e_88ad_4634b9b059b1
initial concentration: NaN
has only substance units: false
constant: false
name: DYLX2
boundary condition: true
is encoded by: hsa:9856
is: F5H123
type: Species
initial amount: NaN
is: SBO:0000252

metaM din c
has only substance units: false
type: Species
initial concentration: 1.0
name: Deoxyinosine
initial amount: NaN
is: HMDB00071
is: C05512
is: CHEBI:28997
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: SBO:0000247
constant: false
boundary condition: false

metaR NDPK1
product: MODEL1310110057#
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000134
name: nucleoside-diphosphate kinase (ATP:GDP)
is: SBO:0000176
kinetic law: MODEL1310110057#

metaM 7dhchsterol r
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
name: cholesta-5,7-dien-3beta-ol
is: SBO:0000247
is: HMDB00032
has only substance units: false
type: Species
is: CHEBI:17759

metaR r2194
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is: SBO:0000185
product: MODEL1310110057#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110057#_8070c791_bedf_4102_ad40_93b24ddcf233
name: ENTPD1
has only substance units: false
is: Q86VV3
initial amount: NaN
is encoded by: hsa:953
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_1c778206_2452_4d84_91f7_99cc4ff825f1
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
name: ACPP
boundary condition: true
is: P15309
has only substance units: false
is: SBO:0000252
is encoded by: hsa:55

metaR HPYRRy
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.1.1.79
fast: false
type: Reaction
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:2689175,PMID:9038835 NOTES:JLR
name: Hydroxypyruvate reductase (NADPH)
modifier: MODEL1310110057#
is: SBO:0000176
product: MODEL1310110057#

metaR FATP7t
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.7
name: fatty acid electroneutral transport
is described by: ECO:0000000
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
product: MODEL1310110057#
is: SBO:0000185
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/6.2.1.3

metaM hexdicoa x
initial concentration: 1.0
is: HMDB03932
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
initial amount: NaN
constant: false
name: hexadecanedioylcoa
is: C05258

metaM ksii core2 deg6 l
initial amount: NaN
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 6
boundary condition: false
is: CHEBI:12936
constant: false
notes: FORMULA: C44H72N4O33SX CHARGE: -1
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110057#_f9601676_1d38_45ba_bbd2_4db842e992d6
constant: false
initial concentration: NaN
name: _AI971023_1_c
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI971023
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_82bec579_a1eb_48ba_a8f2_da65bca73a2d
is: B4DYG5
is encoded by: hsa:5297
constant: false
name: PI4KA
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM thp2c x
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB12130
boundary condition: false
has only substance units: false
type: Species
name: 1-piperideine-6-carboxylate
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
is: CHEBI:16987
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_8273674d_48a5_4c86_b154_f4194bded8ee
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:57379
name: AICDA
has only substance units: false
is: SBO:0000252
is: Q546Y9
initial concentration: NaN
type: Species

metaR PIt8
fast: false
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
reactant: MODEL1310110057#
is: SBO:0000185
product: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
name: phosphate transport in/out via Na+ symporter
reversible: true
is described by: ECO:0000006

http://identifiers.org/biomodels.db/MODEL1310110057#_15e70586_2ab3_460a_8601_769a0c241d6c
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:AI697028
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
name: _AI697028_1_m

metaR NDPK5n
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110057#
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
kinetic law: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110057#
product: MODEL1310110057#
reversible: true
is described by: ECO:0000304

metaR r2193
reversible: true
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110057#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110057#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110057#

metaR EX 3aib LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-3-Amino-isobutanoate exchange
type: Reaction

metaR COQ6m
fast: false
modifier: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (51004.1) or (51004.2) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.13.12.- IT
reversible: false
product: MODEL1310110057#
is described by: ECO:0000269
is: SBO:0000176
name: Ubiquinone biosynthesis monooxgenase COQ6

metaR PTDCACRNt
kinetic law: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
name: pentadecanoate transport into the mitochondria
fast: false
reactant: MODEL1310110057#
reversible: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110057#
is: SBO:0000185

metaR CYTK10
type: Reaction
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
name: cytidylate kinase (CMP,dGTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
is: SBO:0000176
product: MODEL1310110057#
modifier: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269

metaM ile L e
is: CHEBI:17191
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: L-isoleucine
is: HMDB00172

http://identifiers.org/biomodels.db/MODEL1310110057#_b5741751_0148_4d81_85db_8a8b126572b2
constant: false
name: _AA081045_1_m
has only substance units: false
initial amount: NaN
is encoded by: hsa:AA081045
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_1dcf4799_aaad_414a_8099_cc7cb171ebb0
initial concentration: NaN
has only substance units: false
is encoded by: hsa:7264
initial amount: NaN
is: Q13630
type: Species
is: SBO:0000252
boundary condition: true
name: TSTA3
constant: false

metaR C120CPT1
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanoylcarnitine
type: Reaction

metaR r2196
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110057#
is: SBO:0000185
kinetic law: MODEL1310110057#
fast: false
modifier: MODEL1310110057#
product: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_0ff08cc6_701e_40fd_91f6_ba2ed52fc514
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P03915
type: Species
name: ND5
is encoded by: hsa:4540
constant: false
has only substance units: false
boundary condition: true

metaR ACNAM9PL
is described by: ECO:0000269
is: SBO:0000176
fast: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD
modifier: MODEL1310110057#
type: Reaction
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
is version of: http://identifiers.org/ec-code/2.5.1.56
reactant: MODEL1310110057#
reversible: false
product: MODEL1310110057#

metaR FAOXC221C201x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_115dd4ab_75aa_4188_a4b4_6538a2767f33
has only substance units: false
type: Species
is: O43678
initial amount: NaN
constant: false
is: SBO:0000252
name: NDUFA2
is encoded by: hsa:4695
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_9a4e4a76_9ef5_4258_b8a5_57ab5e0136ca
initial amount: NaN
is: Q9UPR5
constant: false
type: Species
name: SLC8A2
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6543

metaM met L c
is: SBO:0000247
name: L-methionine
constant: false
has only substance units: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: CHEBI:16643
is: HMDB00696
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM ksii core2 pre10 g
has only substance units: false
is: CHEBI:28067
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 10
type: Species

metaR r1980
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000185
name: Y+LAT2 Utilized transport
reversible: false
fast: false

metaR r2195
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110057#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110057#
reactant: MODEL1310110057#
modifier: MODEL1310110057#

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaM 3hibutcoa m
is: HMDB01052
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
initial amount: NaN
initial concentration: 1.0
name: (S)-3-Hydroxyisobutyryl-CoA
constant: false
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:28259
is: SBO:0000247

metaM glx x
is: SBO:0000247
is: CHEBI:36655
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: glyoxylate
is: HMDB00119
has only substance units: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
boundary condition: false

metaR S6T16g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
is: SBO:0000176
product: MODEL1310110057#
modifier: MODEL1310110057#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_2967cd8f_afe8_4029_8fbb_df483946349a
type: Species
name: CMPK1
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: B2R6S5
is: SBO:0000252
is encoded by: hsa:51727
initial concentration: NaN

metaR PRPNCOAHYDm
name: Propenoyl-CoA hydrolase (m)
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
product: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
is described by: ECO:0000134
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/4.2.1.18
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110057#_84da6334_88f9_4646_b4bf_a40a0f50d33d
has only substance units: false
initial amount: NaN
is encoded by: hsa:1738
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: DLD
is: P09622
constant: false
type: Species

metaM dhcholestancoa r
is: HMDB02159
constant: false
is: CHEBI:15494
has only substance units: false
type: Species
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
initial amount: NaN

metaR 4HBZFm
reversible: false
product: MODEL1310110057#
fast: false
name: 4-hydroxybenzoate formation
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
is: SBO:0000176
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110057#_49952575_dd89_41dd_9fcd_76a28a8966cd
name: SLC3A2
is: SBO:0000252
initial concentration: NaN
is: P08195
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:6520
type: Species

metaM 56dthm m
has only substance units: false
is: HMDB00079
name: 5,6-dihydrothymine
type: Species
boundary condition: false
is: CHEBI:27468
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
constant: false

metaR PIPLCn
product: MODEL1310110057#
name: phosphatidylinositol phospholipase C, nucleus
reversible: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.1.4.11
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_6b5f05fd_6872_4371_b01f_50e6028047fb
name: IDH3A
boundary condition: true
constant: false
is: P50213
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3419
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_68197686_0dc0_4105_8ca4_95344abb52a8
initial amount: NaN
has only substance units: false
is encoded by: hsa:10327
boundary condition: true
name: AKR1A1
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_69f765b1_eb9b_4f66_9226_0e101c237c70
name: _AI990637_1_x
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:AI990637

http://identifiers.org/biomodels.db/MODEL1310110057#_b6f6d467_62cb_4b97_97fa_fc6da3bb6140
initial concentration: NaN
is: SBO:0000252
name: TRNT1
is encoded by: hsa:51095
boundary condition: true
constant: false
has only substance units: false
type: Species
is: Q96Q11
initial amount: NaN

metaM ak2lgchol hs e
constant: false
has only substance units: false
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
type: Species
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
boundary condition: false
is: http://identifiers.org/pubchem.compound/6975
is: C04317
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR RE2973C
is version of: http://identifiers.org/ec-code/2.7.1.153
type: Reaction
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: true
modifier: MODEL1310110057#
name: RE2973
is version of: http://identifiers.org/ec-code/2.7.1.137
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.1.154
is described by: ECO:0000000
kinetic law: MODEL1310110057#

metaR GALASE6ly
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110057#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110057#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: false
name: beta-galactosidase, lysosomal

metaM creat e
initial amount: NaN
is: CHEBI:16919
is: HMDB00064
boundary condition: false
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: creatine
type: Species

metaR C60CPT1
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexanoylcarnitine
type: Reaction

metaM ile L c
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: L-isoleucine
type: Species
is: CHEBI:17191
boundary condition: false
is: HMDB00172

metaR r2198
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is: SBO:0000185
fast: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
reactant: MODEL1310110057#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110057#
modifier: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_8c72d64a_95af_4924_a245_72799b96292c
initial amount: NaN
is encoded by: hsa:4351
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is: P34949
boundary condition: true
name: MPI
initial concentration: NaN

metaM met L e
initial concentration: 1.0
name: L-methionine
has only substance units: false
is: HMDB00696
is: CHEBI:16643
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false

metaR METyLATthc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Methionine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaR r2197
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_4970af4a_4a29_4c59_9a06_e189bd5ffb01
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:728441
name: GGT2
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_8fa632cd_bd02_458a_b3be_19f5e5ee06bc
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
name: TXNRD1
has only substance units: false
boundary condition: true
is encoded by: hsa:7296
initial amount: NaN

metaM 3octdeccrn c
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
name: 3-hydroxyoctadecanoyl carnitine
type: Species
notes: FORMULA: C25H49NO5 CHARGE: 0
is: HMDB13336
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_1da56033_c70a_4bdd_9329_ca9f2bd419c8
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6472
name: SHMT2
constant: false
is: B4DJQ3
initial amount: NaN
boundary condition: true

metaM docosahexcoa m
has only substance units: false
constant: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
name: 3,7,10,13,16,19-docosahexenoylcoa
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
is: SBO:0000247

metaR KHK2
fast: false
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.3 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.1.3
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110057#
kinetic law: MODEL1310110057#
name: ketohexokinase (D-xylulose)
reactant: MODEL1310110057#
type: Reaction
reversible: false

metaM pydx5p e
boundary condition: false
constant: false
notes: FORMULA: C8H8NO6P CHARGE: -2 INCHI: InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)/p-2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
name: pyridoxal 5'-phosphate(2-)
is: HMDB01491
is: CHEBI:597326

http://identifiers.org/biomodels.db/MODEL1310110057#_e4c8d0a1_4c66_466b_a5fd_4ae3e566b127
type: Species
is: O75251
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:374291
initial concentration: NaN
constant: false
has only substance units: false
name: NDUFS7

metaR r0666
modifier: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
is: SBO:0000176
type: Reaction
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
is version of: http://identifiers.org/ec-code/1.2.4.2

metaR r2315
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
product: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR 4HOXPACDOX NADP
reactant: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110057#
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
product: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
is: SBO:0000176
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110057#_5cdab77c_4f58_4b0f_af44_2f34ebeada5f
has only substance units: false
name: CHAT
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1103
is: D3DX95
constant: false
is: SBO:0000252
type: Species
initial amount: NaN

metaM ksi deg26 l
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00061
is: SBO:0000247
type: Species
initial amount: NaN
name: keratan sulfate I, degradation product 26
constant: false
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
is: CHEBI:58343

metaR r1172
is: SBO:0000176
reactant: MODEL1310110057#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110057#
reversible: false
fast: false
kinetic law: MODEL1310110057#
name: EC:3.1.1.13
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110057#_0fe52bb1_0d10_4aa3_975b_82582522bf5f
constant: false
boundary condition: true
type: Species
is: Q9UJ70
name: NAGK
is: SBO:0000252
is encoded by: hsa:55577
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_e1387a9e_4a6e_4a78_a0c4_7cff95138b29
initial amount: NaN
is: SBO:0000297
constant: false
boundary condition: true
initial concentration: NaN
has part: Q9P2X0
is encoded by: hsa:8818
has only substance units: false
is encoded by: hsa:54344
name: DPM3:DPM1:DPM2
type: Species

metaM anth c
type: Species
boundary condition: false
is: CHEBI:16567
is: SBO:0000247
is: HMDB01123
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
name: anthranilate

metaR GGT6
type: Reaction
reactant: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
kinetic law: MODEL1310110057#
fast: false
product: MODEL1310110057#
is: SBO:0000176
name: Gamma-glutamyltransferase
reversible: true

metaR DESAT18 4
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
is version of: http://identifiers.org/ec-code/1.14.19.1
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: false
modifier: MODEL1310110057#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110057#

metaM HC02202 e
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
is: SBO:0000247
type: Species
initial concentration: 1.0
name: prostaglandin A1(1-)
is: CHEBI:57398
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_8580b846_9334_4917_8eb3_9e78934d0cce
is encoded by: hsa:231
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
name: AKR1B1
type: Species
has only substance units: false
is: P15121

metaR EX urea LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urea exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_cf0cba4a_1fe1_4c1b_a166_13bb63392792
is: Q96PD7
boundary condition: true
is encoded by: hsa:84649
initial amount: NaN
name: DGAT2
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_0caab929_2d7c_483c_8702_0bb872b145f4
initial amount: NaN
type: Species
boundary condition: true
name: SHMT1
is: SBO:0000252
is encoded by: hsa:6470
constant: false
initial concentration: NaN
has only substance units: false

metaR ADPACTD
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport into cytosol (diffusion)
type: Reaction

metaR r2316
reversible: true
fast: false
product: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_22652725_624a_47de_8d4b_25febe7c8ac2
constant: false
is: B4E097
is encoded by: hsa:2592
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
name: GALT

metaM sphmyln hs g
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:58216
initial concentration: 1.0
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
name: sphingomyelin betaine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_9d67d4a3_40b1_4152_8255_5f25925192ec
constant: false
initial amount: NaN
is encoded by: hsa:386757
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: SLC6A10P
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_3b6693d6_87af_40c3_82d7_64037b0ac479
constant: false
type: Species
is: P53004
has only substance units: false
initial concentration: NaN
is encoded by: hsa:644
is: SBO:0000252
name: BLVRA
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_3e9eff24_c144_4a25_9216_b5d4095dc12e
has part: B7Z2T0
is: SBO:0000297
boundary condition: true
type: Species
initial amount: NaN
name: ATP1A3:ATP1B1
is encoded by: hsa:478
has part: A3KLL5
constant: false
initial concentration: NaN
is encoded by: hsa:481
has only substance units: false

metaM 3hexdcrn c
initial amount: NaN
name: 3-hydroxyhexadecanoylcarnitine
constant: false
has only substance units: false
notes: FORMULA: C23H45NO5 CHARGE: 0
type: Species
is: SBO:0000247
is: HMDB13336
boundary condition: false
initial concentration: 1.0

metaR r2313
is described by: ECO:0000000
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110057#
reversible: true

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

metaR DINt
is: SBO:0000185
fast: false
type: Reaction
reversible: true
name: deoxyinosine transport via diffusion
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000000
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110057#_28773249_f0d2_47b2_b7bb_88397b16e68c
boundary condition: true
initial concentration: NaN
is: Q9HCR9
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:50940
has only substance units: false
name: PDE11A
is: SBO:0000252

metaM pydx5p c
notes: FORMULA: C8H8NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
initial concentration: 1.0
is: CHEBI:597326
is: SBO:0000247
boundary condition: false
is: HMDB01491
initial amount: NaN
name: Pyridoxal 5'-phosphate
constant: false
has only substance units: false
type: Species
is: C00018

metaR SIAASE3ly
is version of: http://identifiers.org/ec-code/3.2.1.23
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000176
product: MODEL1310110057#
is described by: ECO:0000000
reversible: false

metaR Ser Thrtg
name: Ser/Thr transport (from golgi to lysosome)
is: SBO:0000185
reversible: true
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
kinetic law: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110057#_fead0f4b_4802_491a_8b81_c35d4ed56e34
type: Species
name: DPM3
is encoded by: hsa:54344
constant: false
initial concentration: NaN
is: Q9P2X0
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaM m2emgacpail hs r
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:24636
constant: false
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
is: C00080

metaM CE2435 m
is: CHEBI:57795
initial amount: NaN
constant: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
name: trans,cis-deca-2,4-dienoyl-CoA

metaM glyc3p x
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:57597
boundary condition: false
is: HMDB00126
initial amount: NaN
is: C00093
constant: false
has only substance units: false
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
name: Glycerol 3-phosphate

metaR r2314
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110057#_1bf6523f_1473_4a83_a156_9a57d4cf58ec
type: Species
has part: Q9BRB3
is encoded by: hsa:5277
has part: O94777
boundary condition: true
is: SBO:0000297
is encoded by: hsa:5283
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has only substance units: false
has part: Q14442
is encoded by: hsa:51227
is encoded by: hsa:9091
has part: Q92535
is encoded by: hsa:8818
is encoded by: hsa:5279
constant: false
has part: B3KUV7
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_9ae254e2_95ea_45a4_89e8_ea1ca491b314
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:2110
type: Species
name: ETFDH
is: SBO:0000252
is: Q16134
initial amount: NaN
has only substance units: false

metaM 3hmbcoa m
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:57312
type: Species
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB01356
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405

metaM HC02202 c
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
initial concentration: 1.0
has only substance units: false
is: CHEBI:57398
constant: false
name: prostaglandin A1(1-)
boundary condition: false

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaM ksii core2 pre3 g
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58053
type: Species
name: keratan sulfate II biosynthesis, precursor 3
is: HMDB00175
is: C00130
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C47H76N4O33X CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110057#_1e6c70cf_191f_4571_b234_ac4a80da4333
is encoded by: hsa:93010
boundary condition: true
is: Q8NFL0
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: B3GNT7
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_d4b5d90e_3ec4_4105_be3a_2b784db52a0e
is: SBO:0000252
is encoded by: hsa:3101
boundary condition: true
name: HK3
initial concentration: NaN
is: P52790
constant: false
type: Species
has only substance units: false
initial amount: NaN

metaM pro D e
is: HMDB03411
initial concentration: 1.0
boundary condition: false
name: D-proline
is: SBO:0000247
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
has only substance units: false
is: CHEBI:16313
constant: false
initial amount: NaN
type: Species

metaM bhb c
name: (R)-3-hydroxybutyrate
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
type: Species
is: SBO:0000247
is: HMDB00011
constant: false
is: CHEBI:10983
has only substance units: false
initial concentration: 1.0

metaR PAPStg
fast: false
type: Reaction
modifier: MODEL1310110057#
name: 3'-Phosphoadenylyl sufate Golgi transport
reversible: true
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000185
reactant: MODEL1310110057#

metaM acgam l
boundary condition: false
name: N-acetyl-D-glucosamine
has only substance units: false
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: CHEBI:17411
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00215
constant: false

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaM 44mzym r
initial concentration: 1.0
constant: false
is: HMDB01286
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
is: CHEBI:18364
name: 14-demethyllanosterol
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN

metaM Lkynr c
is: SBO:0000247
is: HMDB00684
name: L-kynurenine
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
is: CHEBI:16946
constant: false

metaR r2319
fast: false
type: Reaction
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR C141CPT1
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecenoylcarnitine
type: Reaction

metaR BUP2
fast: false
name: beta-ureidopropionase (D-3-amino-isobutanoate forming)
is described by: ECO:0000269
is: SBO:0000176
reversible: false
modifier: MODEL1310110057#
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.5.1.6
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:11508704,PMID:5773299 NOTES:MM

metaM urate c
is: C00366
initial amount: NaN
is: HMDB00289
initial concentration: 1.0
has only substance units: false
name: Urate
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
boundary condition: false
is: CHEBI:17775
constant: false
is: SBO:0000247
type: Species

metaM prgnlone m
type: Species
is: CHEBI:16581
constant: false
name: pregnenolone
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00253
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953

http://identifiers.org/biomodels.db/MODEL1310110057#_96a23bbe_6608_4e2e_b91c_e8e55f6177fe
type: Species
has only substance units: false
constant: false
boundary condition: true
name: _AV717590_1_c
is encoded by: hsa:AV717590
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_cd43223c_fd65_48e3_9d2b_07d7a8cec6bc
is: Q6FGA0
initial concentration: NaN
initial amount: NaN
constant: false
name: COX7A2L
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:9167
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_25c53358_e5c6_46fb_a5b9_9e458725921a
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
name: PLD1
is: Q59EA4
is encoded by: hsa:5337

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaR MALSO4tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
modifier: MODEL1310110057#
fast: false
product: MODEL1310110057#
name: Malate:sulfate antiport, mitochondrial
kinetic law: MODEL1310110057#
type: Reaction
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110057#

metaM l2fn2m2masn g
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
is: CHEBI:28067
constant: false
type: Species
notes: FORMULA: C68H113N4O49X CHARGE: 0
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR FACOAL180i
kinetic law: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
is: SBO:0000176
reactant: MODEL1310110057#
reversible: false
modifier: MODEL1310110057#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
name: C180 fatty acid activation

http://identifiers.org/biomodels.db/MODEL1310110057#_ed19daf9_5be3_46ef_9eaf_4d989190fab5
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: SLC9A4
is: Q6AI14
has only substance units: false
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:389015

metaM pro D c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:16313
boundary condition: false
type: Species
name: D-proline
has only substance units: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: HMDB03411

metaM sphmyln hs c
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
initial concentration: 1.0
initial amount: NaN
name: sphingomyelin betaine
constant: false
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:58216
has only substance units: false

metaR C141ACBP
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradecenoyl coa from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_a322d9b3_3624_4b89_9326_46afdbf5a06b
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: B2RAT6
has only substance units: false
name: GALT
type: Species
is encoded by: hsa:2592
constant: false

metaR EX ddece1crn
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dodecenoyl carnitine
type: Reaction

metaM oaa c
notes: FORMULA: C4H2O5 CHARGE: -2
initial amount: NaN
is: C00036
initial concentration: 1.0
has only substance units: false
is: CHEBI:3338
boundary condition: false
type: Species
is: HMDB00223
constant: false
is: SBO:0000247
name: Oxaloacetate

metaM ddcacoa x
type: Species
boundary condition: false
is: CHEBI:57375
initial concentration: 1.0
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB03571
constant: false
name: Dodecanoyl-CoA (n-C12:0CoA)
is: C01832

metaR r2317
reversible: true
reactant: MODEL1310110057#
type: Reaction
fast: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000185

metaR r0668
reactant: MODEL1310110057#
fast: false
modifier: MODEL1310110057#
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
is version of: http://identifiers.org/ec-code/2.4.2.19
product: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#
reversible: true

metaR GPIMTer L
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
is: SBO:0000176
fast: false
kinetic law: MODEL1310110057#
reversible: false
type: Reaction
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is described by: ECO:0000000
product: MODEL1310110057#

metaM decdp m
notes: FORMULA: C50H81O7P2 CHARGE: -3 INCHI: InChI=1/C50H90O7P2/c1-41(2)21-31-53-58(51,54-32-22-42(3)4)57-59(52,35-25-45(9)10,36-26-46(11)12,37-27-47(13)14,38-28-48(15)16,39-29-49(17)18,40-30-50(19)20,55-33-23-43(5)6)56-34-24-44(7)8/h21-30H,31-40H2,1-20H3
constant: false
boundary condition: false
type: Species
has only substance units: false
is: HMDB06288
initial concentration: 1.0
name: all trans Decaprenyl diphosphate
is: SBO:0000247
initial amount: NaN

metaR ALAASNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110057#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110057#
type: Reaction
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)
fast: false
is described by: ECO:0000269
product: MODEL1310110057#
modifier: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_6cbc234d_0789_46fe_95bc_4d510ca6fd95
is: P49748
name: ACADVL
is encoded by: hsa:37
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species

metaM urate e
initial concentration: 1.0
has only substance units: false
name: Urate
constant: false
is: SBO:0000247
is: CHEBI:17775
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: C00366
initial amount: NaN
boundary condition: false
is: HMDB00289
type: Species

metaR APOCF
fast: false
name: Apocarboxylase formation
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
kinetic law: MODEL1310110057#
is: SBO:0000176
reversible: false
reactant: MODEL1310110057#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_e1332768_3642_41d8_a0f4_a9aedbef31c7
constant: false
is encoded by: hsa:51
name: ACOX1
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: B4DK61
type: Species
boundary condition: true

metaR GLNSERNaEx
is: SBO:0000185
product: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
modifier: MODEL1310110057#
name: L-serine/L-glutamine Na-dependent exchange (Gln-L in)
kinetic law: MODEL1310110057#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110057#

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaM anth e
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:16567
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
constant: false
is: HMDB01123
name: anthranilate

metaR FAOXC15NADPx
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid alpha oxidation(2-Hydroxyphytanoyl-CoA)(nadp)x
type: Reaction

metaR C14OHc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecanoylcarnitine
type: Reaction

metaR FAOXC123x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)x
type: Reaction

metaR r2318
kinetic law: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110057#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110057#
fast: false

metaR EX c8crn
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoyl carnitine
type: Reaction

metaR PPItr
name: Diphosphate transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
type: Reaction
reactant: MODEL1310110057#
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110057#
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_0b71f327_dd33_4d9e_8ab5_3c19d0bc191f
is: O43488
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8574
name: AKR7A2
has only substance units: false
constant: false
type: Species

metaR r0669
reactant: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
kinetic law: MODEL1310110057#
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
product: MODEL1310110057#
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000000

metaR r0779
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
type: Reaction
is: SBO:0000176
product: MODEL1310110057#
reversible: false
modifier: MODEL1310110057#
is described by: ECO:0000000
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM retinol e
is: HMDB00305
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
name: retinol
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:50211
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_f7408ff6_6fa0_47e1_a77a_ad9d897db307
has part: P50213
constant: false
is encoded by: hsa:3421
is encoded by: hsa:3419
type: Species
initial amount: NaN
is encoded by: hsa:3420
initial concentration: NaN
boundary condition: true
has part: E9PDD5
name: IDH3A:IDH3B:IDH3G
has only substance units: false
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110057#_00f4f599_f6a6_4130_87a4_d39128a113aa
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:5140
has only substance units: false
type: Species
name: PDE3B
initial concentration: NaN
is: Q13370

metaR CORE4GTg
is described by: ECO:0000000
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.102
reactant: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
kinetic law: MODEL1310110057#
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
type: Reaction
product: MODEL1310110057#
reversible: false
fast: false

metaR 41R1H2MAE12BOOX
name: 4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
reversible: false
kinetic law: MODEL1310110057#
fast: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.4
is: SBO:0000176

metaR AMPDA
is: SBO:0000176
modifier: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.4.6
name: Adenosine monophosphate deaminase
kinetic law: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
reversible: false
fast: false
reactant: MODEL1310110057#

metaR UMPK
reversible: true
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000176
product: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110057#
name: UMP kinase

http://identifiers.org/biomodels.db/MODEL1310110057#_cd47c7c2_1046_4461_9c02_40c6a97118f7
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:R14373
type: Species
name: _R14373_1_x
boundary condition: true

metaR GK1
is described by: ECO:0000269
name: guanylate kinase (GMP:ATP)
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reactant: MODEL1310110057#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.8

metaM ptdcacoa c
is: HMDB06499
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
name: pentadecanoyl Coenzyme A
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
is: SBO:0000247

metaM ksi deg12 l
has only substance units: false
constant: false
is: CHEBI:12936
is: HMDB00143
type: Species
name: keratan sulfate I, degradation product 12
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
initial amount: NaN
is: SBO:0000247

metaR EX tetdece1crn
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_a11ba11d_e627_4070_ac68_d83b54c1d02d
boundary condition: true
name: PPA2
constant: false
is encoded by: hsa:27068
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q9H2U2
type: Species

metaM HC01401 m
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:27668
type: Species
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
boundary condition: false
is: SBO:0000247
name: (S)-3-Hydroxydodecanoyl-CoA
initial amount: NaN

metaR HOCTDECCRNe
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyoctadecanoyl carnitine into extra cellular space
type: Reaction

metaR 3MOBte
name: Transport of 3-methyl-2-oxobutanoate
product: MODEL1310110057#
reversible: true
is described by: ECO:0000134
fast: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110057#
is: SBO:0000185
type: Reaction

metaM retinol c
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
name: retinol
is: HMDB00305
is: SBO:0000247
is: CHEBI:50211
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_3a6ce290_f840_4ca0_b583_a642654d982d
is: SBO:0000297
boundary condition: true
initial amount: NaN
is encoded by: hsa:5295
constant: false
type: Species
has only substance units: false
name: PIK3CA:PIK3R1
initial concentration: NaN
has part: P27986

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaM bhb e
is: CHEBI:10983
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
initial concentration: 1.0
type: Species
name: (R)-3-hydroxybutyrate
initial amount: NaN
is: HMDB00011
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR AKGDm
is version of: http://identifiers.org/ec-code/1.8.1.4
type: Reaction
is: SBO:0000176
is described by: ECO:0000134
reversible: false
is version of: http://identifiers.org/ec-code/1.2.4.2
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (4967.2) and (1738.1 and 8050.1) and (1743.1) or (4967.1) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Citric acid cycle EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:1542694 NOTES:EC taken from Ligand TV. Genetic
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.3.1.61
reactant: MODEL1310110057#
fast: false
name: 2-oxoglutarate dehydrogenase

http://identifiers.org/biomodels.db/MODEL1310110057#_5bccca39_ea05_40dc_891d_ec292cff0d4a
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q86SF2
is encoded by: hsa:51809
initial amount: NaN
type: Species
name: GALNT7

metaM acgam r
boundary condition: false
is: CHEBI:17411
initial concentration: 1.0
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: HMDB00215
type: Species
initial amount: NaN
has only substance units: false
constant: false
name: N-acetyl-D-glucosamine
is: SBO:0000247

metaM HC01444 e
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
name: Galactosylglycerol
type: Species
has only substance units: false
is: CHEBI:15754

http://identifiers.org/biomodels.db/MODEL1310110057#_b1aaced9_5747_4683_a431_9e922f060d8e
is: O15056
boundary condition: true
initial amount: NaN
name: SYNJ2
type: Species
constant: false
is encoded by: hsa:8871
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM CE2421 m
is: HMDB02329
is: CHEBI:30623
type: Species
initial concentration: 1.0
constant: false
name: (3S)-3-hydroxylinoleoyl-CoA
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_a782c469_8451_4fa0_bdae_7a4cbaebc5b3
type: Species
is encoded by: hsa:4048
name: LTA4H
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P09960

http://identifiers.org/biomodels.db/MODEL1310110057#_e95e4dd8_9e61_4b75_ac81_d4560a1edce7
name: PYCR1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
is: A6NFM2
is encoded by: hsa:5831

http://identifiers.org/biomodels.db/MODEL1310110057#_71217cc4_d2ba_4b10_a86d_12cc1a82b50d
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:10587
has only substance units: false
is: SBO:0000252
name: TXNRD2
is: Q9NNW7
boundary condition: true
constant: false

metaR CHOLESTle
product: MODEL1310110057#
name: hydrolysis of cholesterol ester by cholesterol esterase
type: Reaction
is: SBO:0000176
reversible: false
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/3.1.1.13
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_f514a622_1733_454f_aa98_d0d4308d306e
initial amount: NaN
name: PDE8A
is encoded by: hsa:5151
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_8bbbbdff_bd32_4a2f_8fda_2ea5165ce31a
constant: false
initial concentration: NaN
is: P00414
initial amount: NaN
name: COX3
is encoded by: hsa:4514
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_e57040a3_b794_4b8c_b2ce_7e95358835da
initial concentration: NaN
is: P80404
is encoded by: hsa:18
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: ABAT
type: Species
constant: false
boundary condition: true

metaR PPItm
kinetic law: MODEL1310110057#
name: diphopshate transporter, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
fast: false
product: MODEL1310110057#
reactant: MODEL1310110057#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000134

metaR KCC2t
name: K+-Cl- cotransporter (NH4+)
modifier: MODEL1310110057#
reversible: true
is described by: ECO:0000269
product: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD

metaR EX thf LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_437abce1_66d8_49ec_99c5_60145b701d19
has part: P19404
is encoded by: hsa:4698
is encoded by: hsa:4539
is encoded by: hsa:4540
is encoded by: hsa:4538
is encoded by: hsa:4715
has part: Q7GXY9
is encoded by: hsa:4710
is encoded by: hsa:4694
has part: O95167
has part: Q6IBA0
is encoded by: hsa:4717
has part: Q85KV6
has part: Q549M5
has part: O75489
is encoded by: hsa:4729
is encoded by: hsa:4709
has part: P03905
has part: O95139
is encoded by: hsa:55967
is encoded by: hsa:4535
has part: Q6IBB5
is encoded by: hsa:4731
is encoded by: hsa:4711
is encoded by: hsa:4724
is encoded by: hsa:4723
is encoded by: hsa:4704
is encoded by: hsa:374291
has part: O14561
has part: P56181
is encoded by: hsa:4716
is: SBO:0000297
is encoded by: hsa:4706
boundary condition: true
has part: O00483
is encoded by: hsa:4696
has part: Q9Y6M9
is encoded by: hsa:4695
has part: A8K761
has part: Q6FG42
type: Species
is encoded by: hsa:4718
has part: P28331
has part: F8VQS7
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
has only substance units: false
has part: O95169
has part: P17568
is encoded by: hsa:4720
is encoded by: hsa:4700
is encoded by: hsa:4536
has part: Q13454
has part: B7Z792
is encoded by: hsa:4713
is encoded by: hsa:4712
is encoded by: hsa:51079
has part: P03915
has part: P03897
has part: O95299
has part: O43674
has part: E5KNH5
is encoded by: hsa:4726
is encoded by: hsa:4719
is encoded by: hsa:4725
is encoded by: hsa:4705
is encoded by: hsa:126328
has part: Q16718
has part: O43677
has part: H7C5B8
has part: Q7GXZ1
has part: B1AM93
has part: O43181
is encoded by: hsa:4697
has part: Q7GXZ4
is encoded by: hsa:4537
initial amount: NaN
has part: Q6IBC4
has part: Q9P0J0
has part: O43678
is encoded by: hsa:4722

metaM 4h2oglt m
is: HMDB02070
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
name: 4-hydroxy-2-oxoglutarate(2-)
has only substance units: false
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
is: CHEBI:17742
is: SBO:0000247

metaR r0974
name: Active transport
kinetic law: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
product: MODEL1310110057#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true

metaM CE2838 e
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
name: maltononaose
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
type: Species
constant: false
is: C01936
has only substance units: false

metaM 3hexdcrn e
name: 3-hydroxyhexadecanoylcarnitine
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: false
is: HMDB13336
notes: FORMULA: C23H45NO5 CHARGE: 0

metaM s2l2n2m2mn l
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB06529
notes: FORMULA: C76H123N5O57 CHARGE: -2
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:50570
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

metaM oaa m
is: HMDB00223
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: Oxaloacetate
is: C00036
is: CHEBI:16452
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
constant: false
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_f47d04ac_7bfd_4943_b92e_13dec514c356
is encoded by: hsa:222
is: P48448
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
name: ALDH3B2
boundary condition: true
type: Species
is: SBO:0000252

metaM gpi prot hs r
name: {[(Prot-PE-Man),(PE)-Man],[PE]}-Man-GlcN-acylPI
is: HMDB00220
boundary condition: false
is: C00249
initial concentration: 1.0
is: CHEBI:7896
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2X CHARGE: 0
type: Species

metaM dece4coa x
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: HMDB02145
boundary condition: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
is: SBO:0000247
name: 4-decenoylcoa
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_f8ac33ab_b268_4a3c_bee6_3db3790b6b29
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: ABO
is encoded by: hsa:28
is: P16442
has only substance units: false
constant: false
type: Species

metaM trdrd m
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:15967
boundary condition: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
name: Reduced thioredoxin
constant: false
initial amount: NaN
type: Species

metaR CHOLPtg
product: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110057#
name: choline phosphate intracellular transport
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110057#_67f11bd2_0851_4a61_9008_e4f5476f1745
constant: false
is: Q5JT09
is encoded by: hsa:83549
name: UCK1
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN

metaR RE1254C
reactant: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
name: RE1254
reversible: true
product: MODEL1310110057#
type: Reaction

metaR r0973
fast: false
reactant: MODEL1310110057#
product: MODEL1310110057#
reversible: true
is: SBO:0000185
name: Facilitated diffusion
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
is described by: ECO:0000000
type: Reaction

metaR RE0938E
kinetic law: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (59272.1) SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 0 AUTHORS: PMID:10969042,PMID:11384769,PMID:11815627 NOTES:
name: RE0938
modifier: MODEL1310110057#
type: Reaction
fast: false
product: MODEL1310110057#
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.4.17.23
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_575253ab_5b27_47d1_9889_5726fcf1199c
is encoded by: hsa:4846
type: Species
constant: false
name: NOS3
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: A0S0A7
has only substance units: false
initial amount: NaN

metaR H2Oter
product: MODEL1310110057#
reactant: MODEL1310110057#
reversible: true
name: H2O endoplasmic reticulum transport
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction

metaR DESAT18 8
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
fast: false
reactant: MODEL1310110057#
name: fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
modifier: MODEL1310110057#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
is: SBO:0000176

metaR SUBERICACT
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of suberic acid for formation of suberyl carnitine
type: Reaction

metaR NTD11
is version of: http://identifiers.org/ec-code/3.1.3.5
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Purine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
name: 5'-nucleotidase (IMP)
reversible: false
kinetic law: MODEL1310110057#
fast: false
modifier: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000269
is: SBO:0000176

metaM octd11ecoa m
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB06294
has only substance units: false
type: Species
initial concentration: 1.0
name: 11-octadecenoylcoa
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110057#_4d649e1c_ada6_4595_a23b_a97a01ef8c7a
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:80704
initial concentration: NaN
is: SBO:0000252
is: Q9BZV2
name: SLC19A3
constant: false

metaR FAOXC7C5m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C7-->C5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_ad6985de_5f9c_42cb_9a73_3d9e8638e896
boundary condition: true
is: O15254
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:8310
constant: false
name: ACOX3
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_98f8cb51_199d_453d_a88e_9acc58d112dc
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is: Q6FGV9
is encoded by: hsa:10654
name: PMVK
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_329ffdf3_01b7_46b1_a7cc_2fd66658b88c
is: SBO:0000252
boundary condition: true
type: Species
name: ABAT
constant: false
is encoded by: hsa:18
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR r0660
modifier: MODEL1310110057#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110057#
fast: false
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110057#
is: SBO:0000176
reactant: MODEL1310110057#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_39568645_cfe5_48ca_96fa_eeac1718a0cf
is encoded by: hsa:6548
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
is: P19634
name: SLC9A1
initial amount: NaN

metaR GALGALGALTHCRMte
name: galgalgalthcrm hs transport
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
is: SBO:0000185
product: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_031f6c8a_509a_43cb_9684_e4ed7b87285a
type: Species
boundary condition: true
initial amount: NaN
name: TAZ
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q16635
constant: false
is encoded by: hsa:6901

metaR ALCD21 L
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.1.99.24
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.1.1.1
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
is described by: ECO:0000304
fast: false
type: Reaction
is: SBO:0000176
name: alcohol dehydrogenase (L-1,2-propanediol)
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110057#_3c491f5b_eb13_4e01_8f35_e17e500fd09b
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:5372
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
name: PMM1
is: A8K003

metaR EX CE4724 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: apelin (1-12) exchange
type: Reaction

metaR C30CPT1
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of propionylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_5d685b3c_2afd_44b2_9d67_3660e6228684
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:126328
name: NDUFA11
is: C9JT23
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true

metaR THRGLNexR
product: MODEL1310110057#
reactant: MODEL1310110057#
reversible: true
name: L-threonine/glycine reversible exchange
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is described by: ECO:0000304
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false

metaM lnlncgcoa c
is: SBO:0000247
is: CHEBI:57363
is: HMDB06368
constant: false
has only substance units: false
boundary condition: false
name: gamma-linolenoyl-CoA(4-)
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035

metaR r0661
product: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
reactant: MODEL1310110057#

metaR r0774
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
modifier: MODEL1310110057#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:

metaM thcrm hs g
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:24636
name: trihexosyl ceramide
constant: false
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
initial amount: NaN
boundary condition: false

metaR MI14Ptn
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110057#
reversible: true
name: inositol 1,4-bisphosphate nuclear transport (diffusion)
product: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_fc4af184_0e5c_466e_8908_e19de8baddc3
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3418
initial amount: NaN
constant: false
is: P48735
name: IDH2

metaR GLYBt4 2 r
product: MODEL1310110057#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6539.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
modifier: MODEL1310110057#
name: Betaine transport (sodium symport) (2:1)
type: Reaction
is: SBO:0000185
is described by: ECO:0000269

metaM ksi pre1 g
name: keratan sulfate I biosynthesis, precursor 1
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
constant: false
is: HMDB00175
is: CHEBI:58053
initial amount: NaN
is: C00130
notes: FORMULA: C79H129N5O57X CHARGE: -1
initial concentration: 1.0

metaR FAOXC164C165x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_5d74b836_033a_434e_ada7_2a364b7182a1
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: _AI934540_1_c
constant: false
type: Species
is encoded by: hsa:AI934540

metaR DITPtn
name: dITP nuclear transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110057#
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110057#
product: MODEL1310110057#

metaR SQLSr
type: Reaction
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
kinetic law: MODEL1310110057#
is: SBO:0000176
fast: false
reversible: false
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.5.1.21
name: Squalene synthase

metaM glygn4 e
type: Species
is: CHEBI:4167
initial amount: NaN
notes: FORMULA: C18H31O16X CHARGE: 0
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
is: HMDB00122
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR r2433
reversible: false
fast: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110057#_202a0ece_9018_4320_8492_310cf4b82d5a
is encoded by: hsa:1375
constant: false
is: B7Z5T8
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
name: CPT1B
is: SBO:0000252

metaR UDPtl
reversible: true
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
type: Reaction
is: SBO:0000185
name: udp intracellular transport
is described by: ECO:0000000
fast: false
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_c30d442c_c93b_45a5_b7d0_9b16af0fdd88
boundary condition: true
type: Species
is: Q1EHB4
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
name: SLC5A12
initial amount: NaN
is encoded by: hsa:159963

metaR r1921
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Y+LAT2 Utilized transport
modifier: MODEL1310110057#
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaR RE1691M
type: Reaction
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
is version of: http://identifiers.org/ec-code/2.8.1.1
reversible: true
name: RE1691
product: MODEL1310110057#
is described by: ECO:0000000
reactant: MODEL1310110057#
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000176
fast: false

metaM ha deg1 l
name: hyaluronan degradation product 1
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: CHEBI:16336
has only substance units: false
is: SBO:0000247
notes: FORMULA: C22H33N2O16 CHARGE: -1
initial concentration: 1.0

metaM ksi deg1 e
constant: false
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
is: SBO:0000247
boundary condition: false
name: keratan sulfate I, degradation product 1
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:17268
type: Species
is: HMDB00211

metaR NACHEXA17ly
product: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
reversible: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase A, lysosomal
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_2e433b4f_2669_4d0c_bcaf_f650cc3909c6
type: Species
initial amount: NaN
name: LDHB
initial concentration: NaN
is: P07195
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:3945
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_60c74bb6_7efa_4a69_9d95_6e6f65292ba8
is encoded by: hsa:HG2846-HT2983
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
name: _HG2846_HT2983_1_c
is: SBO:0000252
type: Species
boundary condition: true

metaM dhcrm hs c
is: CHEBI:31488
has only substance units: false
initial amount: NaN
name: dihydroceramide
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
type: Species
is: SBO:0000247

metaR MHISOR
modifier: MODEL1310110057#
name: N-Methylhistamine:oxygen oxidoreductase (deaminating)
kinetic law: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.22
is version of: http://identifiers.org/ec-code/1.4.3.21
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Histidine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:12072962,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:
reactant: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
is: SBO:0000176

metaM paps g
constant: false
initial amount: NaN
is: HMDB01134
is: SBO:0000247
is: CHEBI:58339
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
initial concentration: 1.0
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_acd6c8b8_841b_467c_a30e_c05aa5da3739
initial amount: NaN
has only substance units: false
name: _AA788780_1_c
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:AA788780

metaM ddcacoa m
name: Dodecanoyl-CoA (n-C12:0CoA)
type: Species
has only substance units: false
is: HMDB03571
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
initial concentration: 1.0
is: C01832
is: CHEBI:57375
constant: false
boundary condition: false

metaM pnto R e
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: SBO:0000247
initial amount: NaN
is: CHEBI:7916
is: HMDB00210
type: Species
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
name: (R)-Pantothenate

metaM betald m
is: CHEBI:15710
constant: false
has only substance units: false
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
name: betaine aldehyde
is: SBO:0000247
is: HMDB01252

metaR GALGALGALTHCRMtg
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
is described by: ECO:0000000
type: Reaction
reversible: true
name: galgalgalthcrm hs intracellular transport
reactant: MODEL1310110057#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_b0cc6177_9684_4f57_9780_abe618e2b2d2
boundary condition: true
has only substance units: false
is: SBO:0000252
is: E9PB82
is encoded by: hsa:3295
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
name: HSD17B4

metaM 3htdcoa c
is: HMDB02014
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
name: (S)-3-Hydroxytetradecanoyl-CoA

metaM HC02208 c
is: CHEBI:27696
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
name: prostaglandin-d1
initial concentration: 1.0
boundary condition: false

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

metaM hexdicoa c
constant: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
is: SBO:0000247
name: hexadecanedioylcoa
is: HMDB02014
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false

metaR r0975
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110057#
is: SBO:0000185
product: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
name: Facilitated diffusion
is described by: ECO:0000000

metaR O2tm
name: O2 transport (diffusion)
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110057#
is described by: ECO:0000000
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
is: SBO:0000185
product: MODEL1310110057#

metaM ala L m
is: HMDB00161
name: L-alanine
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
constant: false
is: CHEBI:16977
is: SBO:0000247
initial concentration: 1.0

metaR EX c101crn
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_d6427f0e_c07b_4216_a527_f521ae34bf05
is: SBO:0000252
initial concentration: NaN
type: Species
is: P54709
constant: false
has only substance units: false
is encoded by: hsa:483
initial amount: NaN
boundary condition: true
name: ATP1B3

metaR AG13T4g
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110057#
is described by: ECO:0000000
modifier: MODEL1310110057#
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110057#
kinetic law: MODEL1310110057#

metaR TMDK1m
notes: GENE_ASSOCIATION: (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:9342341 NOTES:TV
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.21
type: Reaction
product: MODEL1310110057#
modifier: MODEL1310110057#
name: thymidine kinase (ATP:thymidine)
reactant: MODEL1310110057#
is described by: ECO:0000269
kinetic law: MODEL1310110057#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_03737c7e_7abd_42c7_bdd0_d64d756a80eb
boundary condition: true
is: P42765
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10449
constant: false
initial amount: NaN
name: ACAA2

http://identifiers.org/biomodels.db/MODEL1310110057#_9bf8b91c_74b7_46b1_bc00_155af24d6553
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
name: _AI631997_1_m
is encoded by: hsa:AI631997
constant: false
initial amount: NaN

metaR FAOXC164m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaR C142ACBP
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradeca dienoyl coa from mitochondria into cytosol
type: Reaction

metaR r0321
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/6.3.5.2
is: SBO:0000176
product: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: false
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
fast: false
kinetic law: MODEL1310110057#

metaM eitetcoa m
is: SBO:0000247
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: 5,8,11,14-eicosatetraenoylcoa

metaR LPCOXp
type: Reaction
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
product: MODEL1310110057#
name: L-pipecolate oxidase, peroxisomal
modifier: MODEL1310110057#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.5.3.1
reversible: false

metaR HMGCOASi
is version of: http://identifiers.org/ec-code/2.3.3.10
name: Hydroxymethylglutaryl CoA synthase (ir)
reversible: false
reactant: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
fast: false
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (3157.1) or (3157.2) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:1358203 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission Made irreversible to match KEGG data for S. aureus

metaM leuktrE4 c
is: HMDB02200
has only substance units: false
initial concentration: 1.0
name: leukotriene E4(1-)
boundary condition: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
type: Species
is: CHEBI:57462
initial amount: NaN
is: SBO:0000247
constant: false

metaR DSREDUCr
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
name: Desmosterol reductase
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.72
reversible: false
reactant: MODEL1310110057#
fast: false
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000134
product: MODEL1310110057#

metaM pnto R c
is: CHEBI:7916
is: HMDB00210
type: Species
initial amount: NaN
constant: false
name: (R)-Pantothenate
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
boundary condition: false

metaM ksii core4 pre1 g
name: keratan sulfate II biosynthesis, precursor 1
has only substance units: false
is: CHEBI:28067
is: SBO:0000247
type: Species
notes: FORMULA: C36H60N3O25X CHARGE: 0
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false

metaR r0559
modifier: MODEL1310110057#
reversible: true
reactant: MODEL1310110057#
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.3

metaM ksi deg41 l
constant: false
is: CHEBI:12936
is: HMDB00143
name: keratan sulfate I, degradation product 41
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C34H58N2O26 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110057#_36518cfb_d07b_4908_83ff_3eb441750dca
is: B4DKS0
boundary condition: true
initial amount: NaN
is encoded by: hsa:6566
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: SLC16A1

metaR 2OXOADOXm
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
is version of: http://identifiers.org/ec-code/1.2.4.2
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.61
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
fast: false
product: MODEL1310110057#
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
type: Reaction
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.8.1.4
is described by: ECO:0000304

metaM ser D e
is: SBO:0000247
name: D-serine
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB03406
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: CHEBI:16523
has only substance units: false
constant: false
boundary condition: false

metaM dlnlcgcrn c
name: dihomo-gamma-linolenyl carnitine
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB01311
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
type: Species
is: CHEBI:16004

http://identifiers.org/biomodels.db/MODEL1310110057#_35edd5ef_90f1_4464_8ca6_6989131aae7a
is: SBO:0000252
name: PFKFB3
has only substance units: false
is: Q16875
is encoded by: hsa:5209
type: Species
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_82a78fc7_ca93_4f14_bcd4_73b22442e53e
initial amount: NaN
is: SBO:0000297
has only substance units: false
boundary condition: true
has part: B2R892
constant: false
is encoded by: hsa:1158
initial concentration: NaN
name: CKB:CKM
type: Species

metaR APOC LYS BTNPm
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000176
kinetic law: MODEL1310110057#
reversible: false
name: proteolysis of apoC-Lys-btn, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false

metaR G14T14g
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110057#
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110057#
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

metaM HC02208 e
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
is: CHEBI:27696
name: prostaglandin-d1
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_d86aa647_f6e0_4756_aee9_c512006591a2
name: PPT2
boundary condition: true
initial concentration: NaN
is encoded by: hsa:9374
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: Q9UMR5

metaM galgluside hs g
is: HMDB00295
is: SBO:0000247
name: galactosyl glucosyl ceramide
is: C00015
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
has only substance units: false
boundary condition: false
is: CHEBI:58223
type: Species

metaR r0558
is described by: ECO:0000000
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110057#
product: MODEL1310110057#
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
fast: false
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.5.1.3

metaR F1PGT
reversible: true
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110057#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.30
product: MODEL1310110057#
name: fucose-1-phosphate guanylyltransferase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_83e48459_728d_4d82_8124_411a9b4d4684
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: E5KNH5
name: NDUFV1
boundary condition: true
is encoded by: hsa:4723
constant: false
type: Species

metaM leuktrE4 e
is: HMDB02200
constant: false
boundary condition: false
name: leukotriene E4(1-)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:57462
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
type: Species
has only substance units: false

metaR G14T7g
product: MODEL1310110057#
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110057#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110057#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

metaR O16G1e
is: SBO:0000176
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
reversible: false
name: oligo-1,6-glucosidase (glygn4 -> glygn5), extracellular
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.2.1.10
is described by: ECO:0000000
product: MODEL1310110057#
type: Reaction

metaM HC01399 m
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
has only substance units: false
boundary condition: false
name: (S)-3-Hydroxytetradecanoyl-CoA
is: CHEBI:27466

http://identifiers.org/biomodels.db/MODEL1310110057#_2dfb4c95_f222_49f9_b765_b5f6983c54c9
type: Species
is: SBO:0000297
is encoded by: hsa:54965
has part: Q9H3S5
has only substance units: false
has part: Q8TBF5
initial concentration: NaN
name: PIGX:PIGM
constant: false
initial amount: NaN
is encoded by: hsa:93183
boundary condition: true

metaM arachcoa c
constant: false
is: CHEBI:15527
is: HMDB04258
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
name: arachidyl coenzyme A
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false

metaR C162OHe
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C16:2OH
type: Reaction

metaM paps c
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB01134
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
initial concentration: 1.0
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
initial amount: NaN
is: CHEBI:58339
type: Species
has only substance units: false

metaM ala L e
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
has only substance units: false
type: Species
is: HMDB00161
name: L-alanine
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:16977
constant: false

metaM dhor S c
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB03349
name: (S)-dihydroorotate
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
is: CHEBI:30864
type: Species
initial amount: NaN
has only substance units: false

metaR r0829
is described by: ECO:0000000
product: MODEL1310110057#
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.37
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110057#

metaR r1926
fast: false
product: MODEL1310110057#
is described by: ECO:0000000
reactant: MODEL1310110057#
modifier: MODEL1310110057#
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110057#

metaM ser D c
name: D-serine
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
has only substance units: false
is: HMDB03406
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:16523
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_e5ba92bc_7bd1_44e9_9a4a_27d103f9f527
is encoded by: hsa:1109
initial concentration: NaN
initial amount: NaN
is: P17516
constant: false
boundary condition: true
type: Species
name: AKR1C4
has only substance units: false
is: SBO:0000252

metaM ksi deg1 l
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
type: Species
has only substance units: false
initial amount: NaN
name: keratan sulfate I, degradation product 1
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00174
constant: false
is: CHEBI:18287

metaR 34DHOXPEGt
fast: false
kinetic law: MODEL1310110057#
name: 3,4-Dihydroxyphenylethyleneglycol transport (diffusion)
reversible: true
product: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:7473774 NOTES:SAB
type: Reaction
reactant: MODEL1310110057#
is described by: ECO:0000000

metaM CE2418 m
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB11123
is: SBO:0000247
is: CHEBI:28387
initial amount: NaN
boundary condition: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418

http://identifiers.org/biomodels.db/MODEL1310110057#_c7d51b97_e521_47eb_a416_084359326ce0
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:517
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
constant: false
initial concentration: NaN
is encoded by: hsa:9551
boundary condition: true
has part: F8W7V3

metaM ksi deg40 l
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00143
type: Species
has only substance units: false
notes: FORMULA: C40H68N2O31 CHARGE: 0
name: keratan sulfate I, degradation product 40
constant: false
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110057#_1a15d25c_80c1_4c58_8d35_ff3bdc3520d1
initial concentration: NaN
is: Q11203
constant: false
is encoded by: hsa:6487
name: ST3GAL3
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species

metaR NACHEX25ly
product: MODEL1310110057#
kinetic law: MODEL1310110057#
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110057#
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
is: SBO:0000176

metaR r0556
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
reversible: true
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110057#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110057#
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.14.19.1
fast: false

metaR ACETONEt2
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is: SBO:0000185
reactant: MODEL1310110057#
name: acetone transport via proton symport
is described by: ECO:0000269
product: MODEL1310110057#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_590501ba_e4c4_44d0_90bd_31d2486cc624
boundary condition: true
type: Species
name: B4GALT2
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:8704

http://identifiers.org/biomodels.db/MODEL1310110057#_54cedb5b_4998_49ee_a211_2ea500dbe246
initial amount: NaN
constant: false
has only substance units: false
name: GALNT10
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:55568
type: Species
boundary condition: true

metaR C162OHc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxy hexadecadienoyl carnitine
type: Reaction

metaR ALCD21 D
is version of: http://identifiers.org/ec-code/1.1.1.1
is: SBO:0000176
kinetic law: MODEL1310110057#
name: alcohol dehydrogenase (D-1,2-propanediol)
reversible: false
is version of: http://identifiers.org/ec-code/1.1.99.24
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
is described by: ECO:0000304
fast: false
reactant: MODEL1310110057#
type: Reaction
modifier: MODEL1310110057#

metaR GALt4
product: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110057#
fast: false
modifier: MODEL1310110057#
is: SBO:0000185
name: galactose transport via sodium symport
type: Reaction
kinetic law: MODEL1310110057#

metaM trdrd c
is: SBO:0000247
is: CHEBI:15967
constant: false
boundary condition: false
type: Species
is: C00342
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
name: Reduced thioredoxin

http://identifiers.org/biomodels.db/MODEL1310110057#_dc9c7e8d_e096_4fb1_844b_dae51fb92912
is: P78382
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:10559
has only substance units: false
initial concentration: NaN
name: SLC35A1
type: Species
boundary condition: true

metaM dece4coa m
initial amount: NaN
name: 4-decenoylcoa
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB02145
type: Species

metaR O2tp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000000
name: O2 transport, peroxisomal
product: MODEL1310110057#
kinetic law: MODEL1310110057#

metaR r1924
product: MODEL1310110057#
fast: false
modifier: MODEL1310110057#
is described by: ECO:0000000
reactant: MODEL1310110057#
name: Y+LAT2 Utilized transport
reversible: false
kinetic law: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR r1816
kinetic law: MODEL1310110057#
type: Reaction
fast: false
product: MODEL1310110057#
reversible: false
reactant: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
modifier: MODEL1310110057#

metaM eicostet e
name: eicosatetranoic acid
notes: FORMULA: C20H31O2 CHARGE: -1
type: Species
is: CHEBI:36033
has only substance units: false
initial concentration: 1.0
is: HMDB02177
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false

metaR AG13T14g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
is: SBO:0000176
modifier: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#
reversible: false
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.149

metaR r1929
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: false
product: MODEL1310110057#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_54a8a839_167e_4be8_8190_59e7935bae0f
initial amount: NaN
boundary condition: true
constant: false
is: P43007
has only substance units: false
is encoded by: hsa:6509
is: SBO:0000252
name: SLC1A4
type: Species
initial concentration: NaN

metaM 3htdcoa m
type: Species
constant: false
initial concentration: 1.0
is: HMDB02288
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: (S)-3-Hydroxytetradecanoyl-CoA
notes: FORMULA: C35H58N7O18P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110057#_a134afe9_fb9a_4ef8_a1ab_c47bee16096b
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:AA854479
name: _AA854479_1_m
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM ibcoa m
boundary condition: false
is: CHEBI:57338
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
has only substance units: false
type: Species
is: HMDB01243
name: isobutyryl-CoA(4-)
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM c8crn c
is: HMDB00791
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C15H29NO4 CHARGE: 0
name: octanoyl carnitine
has only substance units: false
initial amount: NaN
type: Species
is: C02838
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110057#_59199e53_7aa9_4b5a_8561_e71b4b45d6ab
boundary condition: true
type: Species
initial concentration: NaN
constant: false
name: RRM2B
initial amount: NaN
is: Q7LG56
is: SBO:0000252
has only substance units: false
is encoded by: hsa:50484

http://identifiers.org/biomodels.db/MODEL1310110057#_3739682c_9f46_4aaf_be37_c0791cfcf96f
has only substance units: false
name: LEFTY1
is: O75610
is encoded by: hsa:10637
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaM lpchol hs e
name: lysophosphatidylcholine
is: CHEBI:60479
is: SBO:0000247
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species

metaR r2320
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110057#
type: Reaction

metaR C12DCACT
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of Dodecanedioic acid
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_5b6f37fb_52ef_4511_be33_3ff78dca62fc
constant: false
is encoded by: hsa:4846
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: A0S0A7
has only substance units: false
name: NOS3

metaM CE4723 e
type: Species
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: neocasomorphin (1-5)
constant: false
initial concentration: 1.0
notes: FORMULA: C29H40N5O9 CHARGE: -1 INCHI: InChI=1/C29H41N5O9/c1-16(2)24(26(39)31-20(11-12-23(36)37)28(41)34-14-4-6-22(34)29(42)43)32-25(38)21-5-3-13-33(21)27(40)19(30)15-17-7-9-18(35)10-8-17/h7-10,16,19-22,24,35H,3-6,11-15,30H2,1-2H3,(H,31,39)(H,32,38)(H,36,37)(H,42,43)/p-1/t19-,20-,21-,22-,24+/m1/s1 EHMN_ABBREVIATION: CE4723
boundary condition: false
is: C01936

metaM tdec4ecoa m
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
name: trans4decenoylcoa
is: C08277
is: HMDB00792
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_173e3a50_aeac_4808_b9aa_b0ab3faa3aeb
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is: B3KN25
has only substance units: false
is encoded by: hsa:10390
name: CEPT1

http://identifiers.org/biomodels.db/MODEL1310110057#_40926656_5740_4e5b_93fd_18f74aca1eed
has only substance units: false
name: MUT
is encoded by: hsa:4594
initial amount: NaN
boundary condition: true
is: P22033
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false

metaR DURAD
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.2
is described by: ECO:0000269
name: dihydrouracil dehydrogenase (NADP)
modifier: MODEL1310110057#
product: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
is: SBO:0000176
reactant: MODEL1310110057#
type: Reaction
fast: false

metaR FAOXC164x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_ce80c210_a3e0_4ea3_9481_3c06cb912baf
initial amount: NaN
boundary condition: true
has only substance units: false
name: GGT7
is: SBO:0000252
type: Species
is: A0PJJ9
constant: false
initial concentration: NaN
is encoded by: hsa:2686

http://identifiers.org/biomodels.db/MODEL1310110057#_551e4c86_b1b2_44be_a9e4_6295dfc9298f
has only substance units: false
name: GUCY2D
is encoded by: hsa:3000
type: Species
is: Q02846
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_1d23c496_21a4_498e_857d_4aab8fa9d54d
is encoded by: hsa:1841
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: P23919
name: DTYMK
boundary condition: true
is: SBO:0000252

metaR TMNDNCt
kinetic law: MODEL1310110057#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
is described by: ECO:0000000
product: MODEL1310110057#
reactant: MODEL1310110057#
name: fatty acid transport via diffusion

metaR r0553
fast: false
reversible: true
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
kinetic law: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110057#
product: MODEL1310110057#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_e36a9bfa_2a15_4346_9232_86e28f83a7c9
is encoded by: hsa:728637
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
name: _728637_1_c
type: Species
constant: false

metaR P4508B11r
modifier: MODEL1310110057#
type: Reaction
reversible: false
is: SBO:0000176
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.14.13.95
fast: false
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
is described by: ECO:0000269
name: sterol 12-alpha-hydroxylase
product: MODEL1310110057#

metaM gdpddman c
is: CHEBI:57964
is: SBO:0000247
boundary condition: false
is: HMDB01346
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222
constant: false
initial concentration: 1.0
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)

metaR r0822
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
reversible: true
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
modifier: MODEL1310110057#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110057#_b5565942_8083_4c68_9023_e9234edab6ac
is: P28330
is encoded by: hsa:33
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
name: ACADL
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_a9d95a1f_3770_4933_bc50_badecc96a788
initial concentration: NaN
name: CROT
is: SBO:0000252
is encoded by: hsa:54677
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
is: E7EQF2

metaM Tn antigen g
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
type: Species
notes: FORMULA: C8H14NO5X CHARGE: 0
name: Tn antigen
initial concentration: 1.0
is: C04383

metaM acgam c
has only substance units: false
constant: false
is: HMDB00215
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
type: Species
name: N-acetyl-D-glucosamine
is: CHEBI:17411
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110057#_65d18276_7658_403e_aa04_3b3a418f4d8d
constant: false
is encoded by: hsa:8706
is: Q8TDY1
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
name: B3GALNT1
initial amount: NaN
has only substance units: false

metaM c8crn e
initial concentration: 1.0
is: C02838
initial amount: NaN
is: HMDB00791
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C15H29NO4 CHARGE: 0
type: Species
name: octanoyl carnitine
has only substance units: false

metaR 4NPHSFte
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
fast: false
type: Reaction
name: xenobiotic transport
kinetic law: MODEL1310110057#
is described by: ECO:0000000
product: MODEL1310110057#
reversible: true
reactant: MODEL1310110057#

metaR S6TASE5ly
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
modifier: MODEL1310110057#
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: true
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_d9057987_4d2e_495b_bcf1_a46afe9024eb
constant: false
has only substance units: false
name: FTCD
is: SBO:0000252
is: O95954
initial concentration: NaN
type: Species
is encoded by: hsa:10841
boundary condition: true
initial amount: NaN

metaR r0552
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.3.5.1
reactant: MODEL1310110057#
modifier: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000176
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
type: Reaction
reversible: true

metaM lpchol hs c
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
is: CHEBI:60479
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
type: Species
name: lysophosphatidylcholine

metaR 5MTHFt
is: SBO:0000185
product: MODEL1310110057#
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
kinetic law: MODEL1310110057#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
reversible: true
reactant: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_cfd3dd91_9b17_4318_804a_d33361cc61cf
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:9365
name: KL
is: Q9UEF7
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_1322173f_4522_4645_a086_18216fd5ff1d
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:J03866
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: _J03866_1_m

http://identifiers.org/biomodels.db/MODEL1310110057#_bffee036_5ac8_419b_af5c_39af6466fc61
boundary condition: true
name: PCK2
initial concentration: NaN
is: Q16822
type: Species
has only substance units: false
is encoded by: hsa:5106
initial amount: NaN
constant: false
is: SBO:0000252

metaR PA HSter
name: phosphatidate scramblase
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_05d93a24_e731_41bd_a10a_05073d6d9074
has only substance units: false
type: Species
constant: false
boundary condition: true
is encoded by: hsa:5332
is: SBO:0000252
name: PLCB4
initial concentration: NaN
initial amount: NaN
is: Q15147

metaM ddcacoa c
type: Species
is: C01832
is: SBO:0000247
boundary condition: false
name: Dodecanoyl-CoA (n-C12:0CoA)
is: CHEBI:57375
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
initial amount: NaN
initial concentration: 1.0
is: HMDB03571
has only substance units: false
constant: false

metaR FAOXC164C165m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_b16ab0f3_7ecd_41cd_8fad_2b028b5e62c3
is: SBO:0000252
is: E7EX19
is encoded by: hsa:5295
initial amount: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
name: PIK3R1

metaM dec24dicoa m
has only substance units: false
is: HMDB01168
is: SBO:0000247
initial concentration: 1.0
type: Species
name: 2,4-decadienoylcoa
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_a4235428_e2d3_40fe_b15d_7a925f7d0114
name: OXCT1
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:5019
is: P55809

metaR RETt
reversible: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
type: Reaction
name: Retinol transport via faciliated diffusion
fast: false
is: SBO:0000185
kinetic law: MODEL1310110057#
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_dd8c53f2_e525_4e0e_95a5_d1195068c1b7
is: Q06203
constant: false
is encoded by: hsa:5471
type: Species
initial concentration: NaN
boundary condition: true
name: PPAT
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR UAG4E
is version of: http://identifiers.org/ec-code/5.1.3.2
is: SBO:0000176
product: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
type: Reaction
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000304
name: UDP-N-acetylglucosamine 4-epimerase
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_32497956_ad69_42da_ba7b_e26f87342f01
constant: false
is encoded by: hsa:7001
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: PRDX2
initial concentration: NaN
boundary condition: true

metaR 2OXOADPTm
kinetic law: MODEL1310110057#
name: 2-oxoadipate shuttle (cytosol/mitochondria)
reversible: true
fast: false
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
type: Reaction
is: SBO:0000185
reactant: MODEL1310110057#
is described by: ECO:0000269
product: MODEL1310110057#

metaM cdpdag hs c
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
name: CDP-diacylglycerol(2-)
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
is: CHEBI:58332
initial amount: NaN

metaR r2324
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110057#_2841c71e_0516_4516_8081_b7fba4ac28ae
is encoded by: hsa:11253
initial concentration: NaN
is: Q9UKM7
constant: false
initial amount: NaN
name: MAN1B1
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_190c1ef2_3522_463a_ad62_54e1f13b111e
boundary condition: true
is encoded by: hsa:57786
constant: false
is: SBO:0000252
is: Q9NYW8
name: RBAK
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

metaM hexdicoa r
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
name: hexadecanedioylcoa
is: SBO:0000247
has only substance units: false
is: C08260
is: HMDB00672
notes: FORMULA: C37H59N7O19P3S CHARGE: -5

metaR EX phyt LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phytanic acid exchange
type: Reaction

metaM aps c
initial amount: NaN
is: CHEBI:58243
name: 5'-adenylyl sulfate(2-)
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
is: SBO:0000247
boundary condition: false
type: Species
constant: false
has only substance units: false
is: HMDB01003
initial concentration: 1.0

metaR r0821
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
product: MODEL1310110057#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185
fast: false
type: Reaction

metaR FACOAL170
fast: false
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
is: SBO:0000176
modifier: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110057#

metaR r2323
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#
type: Reaction
is described by: ECO:0000000

metaM k e
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:29103
is: C00238
name: potassium
is: HMDB00586
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
type: Species

metaM dlnlcgcrn m
has only substance units: false
name: dihomo-gamma-linolenyl carnitine
type: Species
is: HMDB01311
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:16004
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3

metaM tmndnccrn m
notes: FORMULA: C27H43NO4 CHARGE: 0 INCHI: InChI=1/C28H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-28(32)33-26(24-27(30)31)25-29(2,3)4/h6-7,9-10,12-13,15-16,18-19,26H,5,8,11,14,17,20-25H2,1-4H3/t26-/m0/s1
constant: false
type: Species
boundary condition: false
name: Timnodonyl carnitine
is: CHEBI:16987
is: SBO:0000247
is: HMDB12130
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR DHCRD2
is described by: ECO:0000269
name: dihydroceramide desaturase
reversible: false
product: MODEL1310110057#
modifier: MODEL1310110057#
is: SBO:0000176
kinetic law: MODEL1310110057#
type: Reaction
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
fast: false
reactant: MODEL1310110057#

metaM ptdcacoa m
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
is: HMDB06499
name: pentadecanoyl Coenzyme A

metaM eitetcoa x
initial amount: NaN
name: 5,8,11,14-eicosatetraenoylcoa
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0

metaR RE1233C
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
product: MODEL1310110057#
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.6.1.64
type: Reaction
fast: false
reversible: true
name: RE1233

http://identifiers.org/biomodels.db/MODEL1310110057#_779e8e58_c370_418e_82c3_bfcdd9a43191
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: AK4
type: Species
is encoded by: hsa:205
is: P27144
has only substance units: false
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_cdce3885_bd51_4114_8fac_5b7f37c69af9
initial concentration: NaN
type: Species
name: ND2
is encoded by: hsa:4536
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q7GXY9
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_a6acb25d_4c49_4088_9c4c_8bea7f6a3a51
constant: false
has part: P38117
boundary condition: true
is: SBO:0000297
type: Species
initial amount: NaN
name: ETFA:ETFB
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2109

metaR THYMt
type: Reaction
kinetic law: MODEL1310110057#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
name: thymine reversible transport via facilated diffusion
is: SBO:0000185
modifier: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_061949dc_2840_42a5_9ca4_4370f3153bf3
is encoded by: hsa:19
is: SBO:0000252
is: O95477
initial amount: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
name: ABCA1

metaR r2322
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110057#
is described by: ECO:0000000
reactant: MODEL1310110057#
product: MODEL1310110057#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185

metaR FAOXC16DCC14DCx
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16DC-->C14DC)x
type: Reaction

metaR CYTK13n
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110057#
type: Reaction
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
product: MODEL1310110057#
name: cytidylate kinase (dCMP,dATP),nuclear
kinetic law: MODEL1310110057#

metaM Tn antigen l
is: C04383
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: Tn antigen
constant: false
notes: FORMULA: C8H14NO5X CHARGE: 0
has only substance units: false
initial concentration: 1.0
type: Species

metaR MM7B2g
reversible: false
fast: false
is described by: ECO:0000000
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
kinetic law: MODEL1310110057#
type: Reaction
modifier: MODEL1310110057#
reactant: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.113

metaR HISCAT1
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaR FAOXC162C162OHm
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:2-->C16:2OH)m
type: Reaction

metaM arachcoa m
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15527
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
name: arachidyl coenzyme A
has only substance units: false
boundary condition: false
type: Species
is: HMDB04258

metaR GLU5Km
type: Reaction
product: MODEL1310110057#
kinetic law: MODEL1310110057#
name: glutamate 5-kinase (m)
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.2.1.41
is: SBO:0000176
fast: false
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 2.7.2.11 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m
reversible: false

metaR PRGNLONEtm
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction
reactant: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#
name: pregnenolone intracellular transport

metaR r2321
is described by: ECO:0000000
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110057#
reversible: true
kinetic law: MODEL1310110057#
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM k c
is: CHEBI:29103
constant: false
is: C00238
type: Species
is: HMDB00586
name: potassium
initial amount: NaN
boundary condition: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM Ser Gly Ala X Gly l
initial concentration: 1.0
has only substance units: false
is: HMDB02183
notes: FORMULA: XH CHARGE: 0
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: protein-linked serine residue (glycosaminoglycan attachment site)
constant: false
is: CHEBI:36005
type: Species

metaR PFK26
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (5210.1) or (5207.1) or (5209.1) or (5208.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.105 Confidence Level: 0 AUTHORS: NOTES:IF
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is: SBO:0000176
reactant: MODEL1310110057#
name: 6-phosphofructo-2-kinase
is version of: http://identifiers.org/ec-code/2.7.1.105

metaR MDHm
reversible: true
kinetic law: MODEL1310110057#
is: SBO:0000176
reactant: MODEL1310110057#
modifier: MODEL1310110057#
fast: false
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.1.1.37
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
name: malate dehydrogenase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110057#_6ec91875_a460_427e_943e_2fac538498a3
constant: false
name: GGT5
has only substance units: false
initial amount: NaN
type: Species
is: P36269
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2687

metaR r0652
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.2
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
kinetic law: MODEL1310110057#
is: SBO:0000176
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reversible: true
product: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_673b2e70_c1a2_4795_b942_782a587d6fa2
is: P08236
is: SBO:0000252
initial concentration: NaN
name: GUSB
type: Species
has only substance units: false
is encoded by: hsa:2990
initial amount: NaN
boundary condition: true
constant: false

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR UGCG
modifier: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
is: SBO:0000176
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.80
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110057#
name: Ceramide glucosyltransferase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110057#_13fe4fb3_20c8_4d22_874f_6ca7f3bf5e66
name: ALDH1A1
is: P00352
type: Species
has only substance units: false
constant: false
is encoded by: hsa:216
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR r0002
reversible: true
product: MODEL1310110057#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110057#
name: Active transport
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110057#_dca96f96_7ba7_4c6c_8624_3efb8bf21f25
name: ESD
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:2098
initial concentration: NaN
is: P10768
initial amount: NaN
boundary condition: true
type: Species

metaM core6 l
has only substance units: false
type: Species
notes: FORMULA: C16H27N2O10X CHARGE: 0
constant: false
is: HMDB00143
boundary condition: false
initial amount: NaN
name: Core 6
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110057#_885fbce8_2f94_4efa_87a8_2f343efa29b5
is: A8K0I1
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: DGKH
constant: false
is encoded by: hsa:160851
type: Species
has only substance units: false
is: SBO:0000252

metaM mlthf c
name: 5,10-Methylenetetrahydrofolate
is: SBO:0000247
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
initial amount: NaN
constant: false
is: C00143
type: Species
has only substance units: false
is: CHEBI:15636
boundary condition: false
is: HMDB01533
initial concentration: 1.0

metaR r0653
reactant: MODEL1310110057#
fast: false
is: SBO:0000176
reversible: false
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110057#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:

metaM acglcgalgluside hs g
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0
has only substance units: false
is: SBO:0000247
is: CHEBI:17103
type: Species
constant: false
initial amount: NaN
name: N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
initial concentration: 1.0
boundary condition: false

metaR AHEXASE2ly
reactant: MODEL1310110057#
is: SBO:0000176
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110057#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
reversible: false
fast: false
kinetic law: MODEL1310110057#

metaM crm hs e
constant: false
is: SBO:0000247
is: CHEBI:52639
type: Species
has only substance units: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
name: N-acylsphingosine
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR 4MPTNLte
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
is described by: ECO:0000000
name: 4-methylpentanal transport
fast: false
reversible: true
is: SBO:0000185
type: Reaction

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaR VACCCRNt
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110057#
is described by: ECO:0000269
modifier: MODEL1310110057#
reversible: false
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_7091e04d_d378_4d77_9827_6a3bc854a089
is encoded by: hsa:6120
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: RPE
initial concentration: NaN
is: Q53TV9
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_ce87027e_522f_4ede_a012_5ee8b12579a3
initial concentration: NaN
name: ATP5A1
is encoded by: hsa:498
is: SBO:0000252
is: B4DY56
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaR FACOAL181i
reversible: false
modifier: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
is version of: http://identifiers.org/ec-code/6.2.1.3
name: C181 fatty acid activation
is described by: ECO:0000269
kinetic law: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
is: SBO:0000176
fast: false

metaR HMGCOAtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
kinetic law: MODEL1310110057#
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110057#
reversible: true
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
product: MODEL1310110057#

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_2847774a_ff6b_4258_bdb8_8bd2cb2a82dc
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:4645
has only substance units: false
initial concentration: NaN
is: Q9H6Y6
name: MYO5B
type: Species
is: SBO:0000252

metaM 5hoxindact c
type: Species
notes: FORMULA: C10H9NO2 CHARGE: 0 INCHI: InChI=1S/C10H9NO2/c12-4-3-7-6-11-10-2-1-8(13)5-9(7)10/h1-2,4-6,11,13H,3H2 HEPATONET_1.0_ABBREVIATION: HC01536 EHMN_ABBREVIATION: C05634
initial amount: NaN
is: CHEBI:50157
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB04073
constant: false
is: SBO:0000247
name: (5-hydroxyindol-3-yl)acetaldehyde

http://identifiers.org/biomodels.db/MODEL1310110057#_d2c9abb1_430d_4e43_b63d_a8c51405aa83
is: Q13615
initial concentration: NaN
is encoded by: hsa:8897
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
name: MTMR3

metaR THD1m
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.6.1.2
fast: false
is described by: ECO:0000269
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES:TDV (2-6-2003)
type: Reaction
name: NAD(P) transhydrogenase
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reversible: true
is: SBO:0000185

metaM thexddcoa m
is: SBO:0000247
is: HMDB02288
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C37H58N7O17P3S CHARGE: -4
name: trans7,10-hexadecadienoylcoa

metaM 3octdece1coa m
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/5280355
name: 3-hydroxyoctadecenoylcoa

metaR r1710
fast: false
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110057#
name: Y+LAT2 Utilized transport
product: MODEL1310110057#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_9064dc63_e017_4822_b295_68f11db9a07a
is encoded by: hsa:483
name: ATP1A1:ATP1B3
constant: false
has only substance units: false
is: SBO:0000297
type: Species
is encoded by: hsa:476
initial amount: NaN
initial concentration: NaN
has part: B7Z3U6
has part: P54709
boundary condition: true

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaM ksi deg11 l
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00143
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
constant: false
name: keratan sulfate I, degradation product 11
is: CHEBI:12936
initial amount: NaN
type: Species

metaM sph1p e
has only substance units: false
is: HMDB01383
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
initial amount: NaN
is: CHEBI:57939
constant: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate

metaM 1pipdn2c x
is: SBO:0000247
is: CHEBI:16187
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
type: Species
is: HMDB01084
initial amount: NaN
name: 1-piperideine-2-carboxylate

metaM mercppyr c
initial amount: NaN
name: 3-mercaptopyruvate
is: SBO:0000247
boundary condition: false
is: HMDB01368
constant: false
has only substance units: false
is: CHEBI:57678
initial concentration: 1.0
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
type: Species

metaR BCDO
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (53630.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.14.99.36 Confidence Level: 4 AUTHORS: PMID:10799297,PMID:11401432,PMID:1503811 NOTES:IT
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.14.99.36
modifier: MODEL1310110057#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110057#
reversible: false
name: beta-Carotene dioxygenase
reactant: MODEL1310110057#
fast: false

metaM dhcholestanate r
boundary condition: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: CHEBI:16577
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00359
constant: false
has only substance units: false

metaR TRDRm
name: thioredoxin reductase (NADPH)
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.8.1.9
reactant: MODEL1310110057#
fast: false
reversible: false
modifier: MODEL1310110057#
product: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES:NCD
type: Reaction

metaR FACOAL191
name: fatty-acid--CoA ligase
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:11591435 NOTES:current models suggest COAL activity occurs on outer peroxisomal membrane NJ
reactant: MODEL1310110057#
product: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110057#

metaR FACOAL80i
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
product: MODEL1310110057#
reactant: MODEL1310110057#
name: fatty-acid--CoA ligase (octanoate)

metaM crm hs c
is: SBO:0000247
is: CHEBI:52639
initial amount: NaN
name: N-acylsphingosine
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
constant: false
boundary condition: false
type: Species

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaR ALADGLNexR
modifier: MODEL1310110057#
product: MODEL1310110057#
kinetic law: MODEL1310110057#
name: L-alanine/glutamine reversible exchange
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110057#
fast: false
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_549ccc8f_7527_476c_8949_64981dc804bd
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:7296
name: TXNRD1
is: SBO:0000252

metaM gtp e
type: Species
initial amount: NaN
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial concentration: 1.0
name: GTP(4-)
has only substance units: false
constant: false
is: CHEBI:37565
is: HMDB01273
is: SBO:0000247
boundary condition: false

metaR EX 3tetd7ecoacrn
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy tetradecenoyl-7-carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_fa13846e_45c0_4c7e_b4af_2758dd88b81b
initial amount: NaN
name: EHHADH
boundary condition: true
initial concentration: NaN
is: Q9NY65
type: Species
is encoded by: hsa:1962
is: SBO:0000252
constant: false
has only substance units: false

metaR AACOAT
is described by: ECO:0000269
modifier: MODEL1310110057#
name: Acetoacetyl-CoA:acetate CoA-transferase
reactant: MODEL1310110057#
is: SBO:0000176
kinetic law: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.16
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_5cf8bc30_3627_4312_b356_11210acf475e
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:6241
type: Species
is: P31350
name: RRM2
initial concentration: NaN
is: SBO:0000252

metaR r0655
kinetic law: MODEL1310110057#
is: SBO:0000176
type: Reaction
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
reactant: MODEL1310110057#
fast: false
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110057#
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.5.1.2

http://identifiers.org/biomodels.db/MODEL1310110057#_6033a1b4_b5db_4cf8_a74f_b66e51d328a9
is: Q9H845
constant: false
has only substance units: false
type: Species
is: SBO:0000252
name: ACAD9
initial concentration: NaN
boundary condition: true
is encoded by: hsa:28976
initial amount: NaN

metaR B3GNT36g
is: SBO:0000176
reactant: MODEL1310110057#
modifier: MODEL1310110057#
fast: false
product: MODEL1310110057#
is described by: ECO:0000269
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
kinetic law: MODEL1310110057#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR FAOXC183C163Gm
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

metaM sphs1p c
is: SBO:0000247
is: HMDB00277
boundary condition: false
constant: false
is: CHEBI:60119
name: sphingosine 1-phosphate(1-)
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
has only substance units: false

metaR MI13PP
is described by: ECO:0000000
is: SBO:0000176
name: inositol-1,3-bisphosphate 3-phosphatase
reversible: false
type: Reaction
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD

metaR LCADi D
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
reversible: false
name: lactaldehyde dehydrogenase
is described by: ECO:0000304
modifier: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.36
is: SBO:0000176
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_7b1ea656_e94e_4095_8488_695611e9e025
name: IK
has only substance units: false
constant: false
boundary condition: true
is: Q13123
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:3550
is: SBO:0000252

metaR UAGDP
product: MODEL1310110057#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.23
reactant: MODEL1310110057#
fast: false
name: UDP-N-acetylglucosamine diphosphorylase
kinetic law: MODEL1310110057#
reversible: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
modifier: MODEL1310110057#

metaM HC00460 c
has only substance units: false
is: CHEBI:58044
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
name: 2,5-dihydroxybenzoate
initial amount: NaN
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
constant: false

metaR r0119
reversible: false
product: MODEL1310110057#
is described by: ECO:0000000
modifier: MODEL1310110057#
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
reactant: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/5.1.3.14
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110057#_85bd90b0_505b_416e_b1b4_80f0f91c64e6
name: ACSL6
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:23305
is: B2RB13
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_8fc09269_6633_44e5_8ac0_6dbd424a0de7
is encoded by: hsa:219
constant: false
is: SBO:0000252
is: P30837
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
name: ALDH1B1

http://identifiers.org/biomodels.db/MODEL1310110057#_cd3ff1ed_7bd5_49f6_871e_fd45031987ba
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: P18545
is encoded by: hsa:5148
type: Species
name: PDE6G
is: SBO:0000252
initial concentration: NaN

metaR S6T9g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110057#
fast: false
modifier: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#

metaM 3aib D c
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
constant: false
initial amount: NaN
name: D-3-Amino-isobutanoate
is: C03265
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB02299

metaM HC01405 m
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:28632
has only substance units: false
name: (S)-Hydroxyoctanoyl-CoA
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
constant: false

metaM gtp c
initial concentration: 1.0
name: GTP
is: SBO:0000247
constant: false
is: HMDB01273
initial amount: NaN
is: C00044
is: CHEBI:37565
has only substance units: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
type: Species
boundary condition: false

metaR PPAm
name: inorganic diphosphatase
kinetic law: MODEL1310110057#
product: MODEL1310110057#
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110057#
reversible: false
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.6.1.1
is described by: ECO:0000269

metaM ptrc c
initial amount: NaN
boundary condition: false
is: CHEBI:326268
constant: false
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB01414
name: Putrescine
is: SBO:0000247
is: C00134

metaR PYDAMK
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110057#
name: pyridoxamine kinase
is version of: http://identifiers.org/ec-code/2.7.1.35
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110057#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110057#

metaM imp e
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: HMDB00175
constant: false
name: IMP(2-)
initial concentration: 1.0
has only substance units: false
is: CHEBI:58053
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247

metaM dhcholestanate m
is: CHEBI:16577
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
boundary condition: false
type: Species
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: HMDB00359

metaM sphs1p e
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
has only substance units: false
is: HMDB00277
constant: false
is: CHEBI:60119
boundary condition: false
initial amount: NaN
name: sphingosine 1-phosphate(1-)
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR BDHm
is described by: ECO:0000269
modifier: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000176
fast: false
reversible: true
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.30
reactant: MODEL1310110057#
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase

metaM 2dr1p c
is: SBO:0000247
is: CHEBI:58576
name: 2-Deoxy-D-ribose 1-phosphate
initial amount: NaN
initial concentration: 1.0
is: C00672
boundary condition: false
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
is: HMDB01351
constant: false
type: Species
has only substance units: false

metaM c5dc e
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C12H21NO6 CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: HMDB13130
name: glutaryl carnitine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_a2e81aa1_cbeb_46d1_a7f7_1346aef9231f
constant: false
is encoded by: hsa:7108
boundary condition: true
has only substance units: false
name: TM7SF2
is: SBO:0000252
is: O76062
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_08afb1f0_702a_462e_8382_577f5c0b72f6
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6241
is: SBO:0000252
is: P31350
has only substance units: false
name: RRM2
constant: false
initial amount: NaN

metaR SPMS
fast: false
notes: GENE_ASSOCIATION: (6723.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.16 Confidence Level: 4 AUTHORS: PMID:2069720,PMID:8343131 NOTES:
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
name: spermidine synthase
type: Reaction
is version of: http://identifiers.org/ec-code/2.5.1.16
product: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110057#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110057#_43deaad1_de81_477b_8928_c8a5d86dbe46
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:8309
is: Q99424
name: ACOX2

metaM c5dc c
type: Species
name: glutaryl carnitine
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB13130
constant: false
notes: FORMULA: C12H21NO6 CHARGE: 0
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110057#_c536ee4e_238b_460e_bb00_1a25a2b609c9
type: Species
is encoded by: hsa:375056
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q5JRA6
is: SBO:0000252
boundary condition: true
name: MIA3

metaM aacoa x
is: CHEBI:57286
is: SBO:0000247
constant: false
is: HMDB01484
has only substance units: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: acetoacetyl-CoA(4-)
type: Species

metaR r2308
product: MODEL1310110057#
is: SBO:0000185
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reversible: true
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction

metaR r0009
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reversible: false
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.1
is: SBO:0000176
reactant: MODEL1310110057#
type: Reaction

metaR FAOXC121C10x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

metaM HC02121 c
name: S-(hydroxymethyl)glutathione(1-)
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
type: Species
is: CHEBI:58758
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_bbc4f41c_d330_441c_af75_0da81e51debe
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:514
constant: false
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is encoded by: hsa:513
is: SBO:0000297

metaR NDPK10
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110057#
product: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:dIDP)
type: Reaction
is: SBO:0000176
fast: false

metaR H8TAer
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (10026.1) and (8733.1) and (128869.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
fast: false
product: MODEL1310110057#
reactant: MODEL1310110057#
name: H8 transamidase, endoplasmic reticulum
modifier: MODEL1310110057#

metaR r2309
reactant: MODEL1310110057#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110057#
product: MODEL1310110057#
fast: false
is: SBO:0000185
type: Reaction

metaR ARACHCPT1
name: carnitine transferase
reversible: false
reactant: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110057#
modifier: MODEL1310110057#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110057#_82336a25_f4e2_408b_9958_3ed8ec9a2f44
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:549
is: SBO:0000252
boundary condition: true
name: AUH
initial concentration: NaN
has only substance units: false
is: Q13825

metaR S6TASE25ly
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110057#
is: SBO:0000176
name: galactose-6-sulfate sulfatase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: true
modifier: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_b60dc969_cf29_4eb2_96cd_82dc509fe090
initial concentration: NaN
name: PDE9A
type: Species
boundary condition: true
constant: false
is encoded by: hsa:5152
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM pail hs n
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: CHEBI:57880
is: SBO:0000247
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194

http://identifiers.org/biomodels.db/MODEL1310110057#_03557f65_9ec2_4cc0_8e13_03b03591cc5d
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
name: _AI440329_1_r
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI440329

metaM ala L c
is: CHEBI:16977
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: L-alanine
is: HMDB00161
is: SBO:0000247
type: Species

metaR TSTSTERONESte
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110057#
is described by: ECO:0000000
type: Reaction
name: sulfonated testosterone transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ

metaR PUNP5
fast: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110057#
is: SBO:0000176
name: purine-nucleoside phosphorylase (Inosine)
is described by: ECO:0000269
modifier: MODEL1310110057#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_c5472ecf_88ad_49c0_859e_b7070daf3f1f
constant: false
boundary condition: true
is: SBO:0000297
initial amount: NaN
name: PIGF:PIGO
type: Species
initial concentration: NaN
has part: Q6IB04
is encoded by: hsa:5281
has only substance units: false
is encoded by: hsa:84720

metaR FAOXC185C164m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_1f374d5c_ef27_4546_8e2c_e6f19e1c6126
has part: Q13733
name: ATP1A4:ATP1B1
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:480
initial concentration: NaN
has only substance units: false

metaR FAOXC142C142OHm
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C14:2OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_8a2a50fb_ca16_4f8b_ab8c_2b03e596eada
initial amount: NaN
is encoded by: hsa:3417
is: O75874
constant: false
type: Species
name: IDH1
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR THRPHELAT2tc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Threonine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR EX adrn LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adrenic acid exchange
type: Reaction

metaR ARACHCPT2
is described by: ECO:0000000
modifier: MODEL1310110057#
reversible: false
reactant: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110057#

metaM lgt S c
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
name: (R)-S-lactoylglutathionate(1-)
is: HMDB01066
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
is: SBO:0000247
constant: false
is: CHEBI:57474

http://identifiers.org/biomodels.db/MODEL1310110057#_15aea4bf_5b54_4e1b_a772_446811fca286
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaR 4MPTNLtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
reversible: true
is described by: ECO:0000000
name: 4-methylpentanal transport (mitochondria)
is: SBO:0000185
fast: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
product: MODEL1310110057#

metaM CE2420 m
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
is: HMDB11123
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
is: SBO:0000247
is: CHEBI:28387
boundary condition: false

metaM betald c
is: CHEBI:15710
has only substance units: false
name: betaine aldehyde
constant: false
initial amount: NaN
boundary condition: false
is: HMDB01252
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR ADSK
is: SBO:0000176
product: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.25
name: adenylyl-sulfate kinase
is described by: ECO:0000269
reactant: MODEL1310110057#
reversible: false
type: Reaction
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#

metaM aacoa m
has only substance units: false
is: HMDB01484
is: CHEBI:57286
type: Species
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: acetoacetyl-CoA(4-)
initial concentration: 1.0
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332

metaM docohepcoa m
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
constant: false
type: Species
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
initial concentration: 1.0
name: 2,4,7,10,13,16,19-docosaheptenoylcoa
boundary condition: false
initial amount: NaN
has only substance units: false

metaR HPETFABP1tc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 5-HPETE into the enterocytes
type: Reaction

metaM CE1935 e
has only substance units: false
initial amount: NaN
constant: false
is: HMDB01423
is: C00010
is: CHEBI:57287
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C10H26N3O CHARGE: 3 INCHI: InChI=1/C10H23N3O/c11-5-3-8-12-6-1-2-7-13-9-4-10-14/h10,12-13H,1-9,11H2/p+3 EHMN_ABBREVIATION: CE1935
is: SBO:0000247
name: spermine monoaldehyde

metaR PUNP4
is: SBO:0000176
modifier: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
type: Reaction
kinetic law: MODEL1310110057#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Deoxyguanosine)
product: MODEL1310110057#
reactant: MODEL1310110057#

metaM sphs1p r
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
type: Species
is: CHEBI:60119
is: HMDB00277
boundary condition: false
name: sphingosine 1-phosphate(1-)

metaM 3aib D m
is: SBO:0000247
name: D-3-Amino-isobutanoate
is: C03265
constant: false
initial concentration: 1.0
is: HMDB02299
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
type: Species
has only substance units: false
initial amount: NaN

metaR UMPKn
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
modifier: MODEL1310110057#
name: UMP kinase, nuclear
product: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
reversible: true
reactant: MODEL1310110057#
is described by: ECO:0000269
type: Reaction

metaM acgal1p c
is: CHEBI:55404
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB06480
has only substance units: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
is: SBO:0000247
initial amount: NaN
name: N-Acetyl-D-galactosamine 1-phosphate
constant: false

metaR EX c10crn
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decanoyl carnitine
type: Reaction

metaR PUNP7
is described by: ECO:0000269
modifier: MODEL1310110057#
name: purine-nucleoside phosphorylase (Xanthosine)
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: true
fast: false
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_f87c8ade_1f18_4bf6_a42c_2f88ac03c468
type: Species
has only substance units: false
is: SBO:0000252
name: GALNT10
initial concentration: NaN
initial amount: NaN
is: Q86SR1
is encoded by: hsa:55568
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_42ee7f18_b19c_4606_9c6a_772f1377b115
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
type: Species
name: LALBA
is: P00709
is: SBO:0000252
is encoded by: hsa:3906
initial concentration: NaN

metaR FAOXC122x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)x
type: Reaction

metaR NAHCO3 HCLt
fast: false
is: SBO:0000185
modifier: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
name: bicarbonate transport (HCl/NaHCO3 exchange)
reactant: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
kinetic law: MODEL1310110057#
is described by: ECO:0000269

metaR BAMPPALDOX
is described by: ECO:0000212
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.36
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
type: Reaction
is: SBO:0000176
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110057#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110057#_e831cc67_ae84_471f_bd8b_76e8b7f66fbd
is: SBO:0000252
initial concentration: NaN
is: F5H6D0
is encoded by: hsa:7841
type: Species
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
name: MOGS

metaR G6Pter
reactant: MODEL1310110057#
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
is: SBO:0000185
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
kinetic law: MODEL1310110057#
product: MODEL1310110057#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_27ce6283_ed4b_41b2_8213_65c8f87f17ef
name: ENTPD5
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:957
boundary condition: true
is: O75356
initial concentration: NaN
initial amount: NaN

metaM pre prot r
type: Species
constant: false
has only substance units: false
name: glycophosphatidylinositol (GPI)-anchored protein precursor
is: CHEBI:16038
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: XY CHARGE: 0
initial amount: NaN

metaR PUNP6
kinetic law: MODEL1310110057#
type: Reaction
name: purine-nucleoside phosphorylase (Deoxyinosine)
fast: false
reactant: MODEL1310110057#
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
product: MODEL1310110057#

metaR THMP
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
name: thiamin phosphatase

metaR ASPTA
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
kinetic law: MODEL1310110057#
type: Reaction
fast: false
modifier: MODEL1310110057#
is: SBO:0000176
product: MODEL1310110057#
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000269
reversible: true
name: aspartate transaminase

metaR r0340
reversible: false
is: SBO:0000176
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
modifier: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.38

metaM glyc S c
is: HMDB06372
constant: false
is: SBO:0000247
notes: FORMULA: C3H5O4 CHARGE: 0
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:33871
initial amount: NaN
name: (S)-Glycerate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110057#_fd7d9413_59b3_4cb8_9aef_ccd0b2bf7720
constant: false
is encoded by: hsa:6489
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is: Q92185
initial amount: NaN
name: ST8SIA1
has only substance units: false

metaR BTNtn
product: MODEL1310110057#
fast: false
reversible: true
name: Biotin transport, nuclear
is described by: ECO:0000000
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
reactant: MODEL1310110057#
type: Reaction
is: SBO:0000185

metaM m7mpdol L r
has only substance units: false
is: SBO:0000247
notes: FORMULA: C1720H2828N20O570P20 CHARGE: -20
constant: false
boundary condition: false
is: CHEBI:37636
initial concentration: 1.0
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
type: Species

metaM sph1p c
initial concentration: 1.0
boundary condition: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: SBO:0000247
is: CHEBI:57939
type: Species
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
is: HMDB01383

metaR r1603
is: SBO:0000185
reversible: true
product: MODEL1310110057#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110057#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110057#

metaR PPDOy
is version of: http://identifiers.org/ec-code/1.1.1.2
modifier: MODEL1310110057#
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.21
reactant: MODEL1310110057#
is: SBO:0000176
product: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110057#_5a593e73_c697_4b31_abde_ab9cf2ad1753
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
has part: Q9UBK5
has part: P48736
name: HCST:PIK3CG
initial amount: NaN
constant: false
is encoded by: hsa:10870
is: SBO:0000297
is encoded by: hsa:5294

http://identifiers.org/biomodels.db/MODEL1310110057#_ad6a51ea_e33b_440c_b271_c0f26c5835c0
type: Species
boundary condition: true
is: SBO:0000252
name: _D87002_1_m
constant: false
initial concentration: NaN
is encoded by: hsa:D87002
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_6bfc8bd2_410a_4c6d_ba8e_3f3966a9bcd0
name: _83530_1_c
is encoded by: hsa:83530
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
has only substance units: false

metaR r0960
is: SBO:0000185
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
is described by: ECO:0000000
fast: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
type: Reaction

metaM m5mpdol L r
constant: false
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:37634
is: SBO:0000247
notes: FORMULA: C1600H2628N20O470P20 CHARGE: -20
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog

metaM 3hmp m
initial concentration: 1.0
is: CHEBI:11805
type: Species
name: 3-hydroxy-2-methylpropanoate
constant: false
initial amount: NaN
boundary condition: false
is: HMDB00023
has only substance units: false
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_da068aa9_f671_4797_8b34_079f8b3cf18f
is encoded by: hsa:2181
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: ACSL3
is: O95573
has only substance units: false
type: Species
initial amount: NaN

metaR G6PDH1rer
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110057#
reversible: true
product: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.1.1.47
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD

metaR NMNATr
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000176
reactant: MODEL1310110057#
is described by: ECO:0000269
name: nicotinamide-nucleotide adenylyltransferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.1
reversible: true

metaM ksi pre29 g
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
is: CHEBI:28067
is: SBO:0000247
constant: false
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 29
boundary condition: false

metaR PPDOx
name: Propane-1,2-diol:NAD+ 1-oxidoreductase
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD
product: MODEL1310110057#
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
fast: false
type: Reaction
reversible: false
is: SBO:0000176
is described by: ECO:0000269

n:
  given: Ines
  family: Thiele

metaR r1602
fast: false
reversible: true
kinetic law: MODEL1310110057#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110057#
type: Reaction

metaM glyc S e
is: HMDB06372
name: (S)-Glycerate
type: Species
notes: FORMULA: C3H5O4 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:33871
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_e833a686_8724_4aa0_8498_e8955911c1c7
initial concentration: NaN
name: _AL050025_1_c
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AL050025
type: Species
constant: false
boundary condition: true
initial amount: NaN

metaM dec24dicoa x
initial concentration: 1.0
is: HMDB01168
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
name: 2,4-decadienoylcoa

http://identifiers.org/biomodels.db/MODEL1310110057#_89573f93_922a_4a11_82e0_08601725859a
initial concentration: NaN
has only substance units: false
is encoded by: hsa:56894
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
is: Q9NRZ7
boundary condition: true
name: AGPAT3

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_d04d16a3_3270_4b18_85c4_65b3e4fa6fe2
is: SBO:0000252
is: Q8TCG5
constant: false
initial amount: NaN
is encoded by: hsa:126129
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
name: CPT1C

http://identifiers.org/biomodels.db/MODEL1310110057#_48048329_6818_42e2_9469_f15695c91b59
name: DGKA
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is: P23743
is encoded by: hsa:1606

metaR UDPACGALtl
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
reactant: MODEL1310110057#
name: udpacgal intracellular transport
reversible: true
kinetic law: MODEL1310110057#
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction

metaM fuc1p L c
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01265
type: Species
has only substance units: false
name: L-Fucose 1-phosphate
initial amount: NaN
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
is: CHEBI:28319
boundary condition: false

metaR r0962
kinetic law: MODEL1310110057#
reversible: false
reactant: MODEL1310110057#
fast: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: Facilitated diffusion

metaM 5pmev x
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00670 EHMN_ABBREVIATION: C01107
type: Species
is: HMDB01343
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:58146
name: (R)-5-phosphonatomevalonate(3-)

metaM ksii core2 pre4 g
constant: false
is: HMDB00175
boundary condition: false
notes: FORMULA: C53H86N4O38X CHARGE: -1
name: keratan sulfate II biosynthesis, precursor 4
type: Species
is: C00130
initial amount: NaN
is: SBO:0000247
is: CHEBI:58053
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110057#_871cf275_6719_4171_9e62_38e2e9dc3a05
is: Q9Y6M9
is encoded by: hsa:4715
boundary condition: true
has only substance units: false
name: NDUFB9
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
type: Species

metaR r0650
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
product: MODEL1310110057#
is: SBO:0000176
kinetic law: MODEL1310110057#
reversible: true
is version of: http://identifiers.org/ec-code/4.1.1.36
type: Reaction
fast: false
reactant: MODEL1310110057#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110057#_7f9864c1_c001_4179_a819_091af478a289
is: P11182
is: SBO:0000252
name: DBT
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:1629
constant: false
initial amount: NaN

metaR r1600
type: Reaction
fast: false
kinetic law: MODEL1310110057#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110057#
is: SBO:0000185

metaR RE3367E
fast: false
product: MODEL1310110057#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110057#
name: RE3367
kinetic law: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110057#

metaR L LACDcm
is described by: ECO:0000000
type: Reaction
name: L-Lactate dehydrogenase, cytosolic/mitochondrial
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (124637.1) SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:18831974 NOTES:NCD/TDV. This reaction exists in yeast, but no evidence could be found this exists in humans. However, there may be intramitochondrial lactate dehydrogenase and lactate transport into mitochondria
reversible: false
reactant: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000185

metaR HESTRATRIOLte
reactant: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be exported NJ
type: Reaction
name: hydroxylated estrogen derivative transport
fast: false
kinetic law: MODEL1310110057#
is described by: ECO:0000000
product: MODEL1310110057#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110057#_b8695ad9_f183_42c3_9428_555fe4787332
name: PIGB
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:9488
constant: false
boundary condition: true
is: Q92521

metaM pmtcoa c
initial concentration: 1.0
type: Species
name: Palmitoyl-CoA (n-C16:0CoA)
is: C00154
boundary condition: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
constant: false
is: CHEBI:3454
initial amount: NaN
is: HMDB01338
has only substance units: false
is: SBO:0000247

metaR CYSGLYexR
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
kinetic law: MODEL1310110057#
reversible: true
modifier: MODEL1310110057#
type: Reaction
name: L-cysteine/glycine reversible exchanger
reactant: MODEL1310110057#

metaR r0651
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
fast: false
is: SBO:0000176
reactant: MODEL1310110057#
reversible: true
product: MODEL1310110057#
type: Reaction
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is described by: ECO:0000000
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.5.1.2

metaR r0961
reactant: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
is described by: ECO:0000000
product: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
reversible: false

metaR ARGtm
name: arginine mitochondrial transport via ornithine carrier
product: MODEL1310110057#
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is described by: ECO:0000269
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV

metaM mescoa m
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
is: CHEBI:27969
boundary condition: false
has only substance units: false
is: C06028
is: SBO:0000247
name: Mesaconyl-CoA
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species

metaR EX 3octdeccrn
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyoctadecanoyl carnitine
type: Reaction

metaR GLYPHEHYc
product: MODEL1310110057#
is described by: ECO:0000134
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
reactant: MODEL1310110057#
name: hydrolysis of glycylphenylalanine
type: Reaction
kinetic law: MODEL1310110057#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110057#_d7b96aac_dc64_454f_aebc_65ea2f784c4c
is: SBO:0000252
type: Species
has only substance units: false
name: ST3GAL3
is encoded by: hsa:6487
boundary condition: true
constant: false
is: Q5T4W8
initial concentration: NaN
initial amount: NaN

metaR G14T13g
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
product: MODEL1310110057#
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110057#
fast: false
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.22

metaM 3hddcoa c
type: Species
initial amount: NaN
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
has only substance units: false
boundary condition: false
name: (S)-3-Hydroxydodecanoyl-CoA
is: HMDB00623
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR MTHFC
fast: false
modifier: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.5.1.5
reactant: MODEL1310110057#
type: Reaction
name: methenyltetrahydrofolate cyclohydrolase
is version of: http://identifiers.org/ec-code/3.5.4.9
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y

metaR r1606
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
is: SBO:0000185
type: Reaction
reversible: true

metaR r0818
reactant: MODEL1310110057#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
name: Transport reaction
product: MODEL1310110057#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110057#
reversible: false

metaR r0963
product: MODEL1310110057#
name: Facilitated diffusion
reactant: MODEL1310110057#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
is described by: ECO:0000000
reversible: false
fast: false
kinetic law: MODEL1310110057#

metaR GCALDD
is: SBO:0000176
is described by: ECO:0000304
reactant: MODEL1310110057#
name: Glycolaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.2.1.36
reversible: false
type: Reaction
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

metaR CHOLt4
modifier: MODEL1310110057#
reactant: MODEL1310110057#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
is: SBO:0000185
name: choline, sodium cotransport
product: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
is described by: ECO:0000269

metaM ctp c
has only substance units: false
is: SBO:0000247
is: C00063
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial amount: NaN
type: Species
is: HMDB00082
constant: false
name: CTP
is: CHEBI:37563
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110057#_256ce66a_4c72_4afb_9be8_ddf5f514d7bb
is: P33402
name: GUCY1A2
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2977
boundary condition: true
type: Species

metaM dhcholestanate c
is: SBO:0000247
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
type: Species
initial amount: NaN
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: CHEBI:16577
initial concentration: 1.0
constant: false
is: HMDB00359
has only substance units: false
boundary condition: false

metaR RE1516M
type: Reaction
modifier: MODEL1310110057#
is: SBO:0000176
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reactant: MODEL1310110057#
is described by: ECO:0000000
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.3.99.13
name: RE1516
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
kinetic law: MODEL1310110057#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110057#_595487c6_0eac_4ccc_b65d_ec54901f5df0
initial concentration: NaN
type: Species
is encoded by: hsa:10449
boundary condition: true
initial amount: NaN
has only substance units: false
is: P42765
name: ACAA2
constant: false
is: SBO:0000252

metaR r0819
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
reactant: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110057#
modifier: MODEL1310110057#

metaM galthcrm hs g
is: CHEBI:26174
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C42H76NO22FULLRCO CHARGE: 0
name: Gal-Gal-Gal-Glc-Cer
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_15a1c43f_4453_4cc8_9a7c_ab96080e481d
is encoded by: hsa:113
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is: P51828
name: ADCY7
has only substance units: false
initial amount: NaN

metaR r1607
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_b62fda6e_8a5b_446d_ba7f_3a171bf06f43
constant: false
has only substance units: false
is: SBO:0000252
type: Species
name: PIGV
boundary condition: true
is: Q9NUD9
is encoded by: hsa:55650
initial amount: NaN
initial concentration: NaN

metaR MTHFD
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
kinetic law: MODEL1310110057#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.5
name: methylenetetrahydrofolate dehydrogenase (NADP)
modifier: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
is described by: ECO:0000134
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110057#_bb378ce6_da3f_4b68_aeaf_839c16ad96d5
name: _BC005314_1_x
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:BC005314
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_8d055b3a_e92c_47fd_b72a_cf380d46e3ac
type: Species
initial concentration: NaN
name: ATP5D
is encoded by: hsa:513
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: P30049
constant: false
has only substance units: false

metaR SERTHRNaEx
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-serine/L-threonine Na-dependent exchange (Ser-L in)
reversible: false
modifier: MODEL1310110057#
fast: false
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110057#
type: Reaction
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_6d909a3e_d13d_454a_a5f5_74cf36482f4a
initial concentration: NaN
is encoded by: hsa:4830
boundary condition: true
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: NME1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_0802358a_56c0_4a88_8be0_4958b0a9c253
initial amount: NaN
boundary condition: true
constant: false
name: ATP2B4
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:493
is: P23634
type: Species

metaM m3mpdol L c
has only substance units: false
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C1480H2428N20O370P20 CHARGE: -20
initial concentration: 1.0
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human liver homolog
initial amount: NaN
is: CHEBI:37632
boundary condition: false

metaM aacoa c
constant: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
name: Acetoacetyl-CoA
has only substance units: false
is: CHEBI:57286
is: C00332
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB01484

metaR r1604
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110057#
is described by: ECO:0000000
kinetic law: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
reversible: true

metaM adrn c
initial amount: NaN
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:53487
has only substance units: false
is: HMDB02226
name: adrenic acid
constant: false

metaR AG13T3g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
reversible: false
product: MODEL1310110057#
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110057#
type: Reaction
modifier: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176

metaM lnlncgcoa m
type: Species
is: CHEBI:57363
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: HMDB06368
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
name: gamma-linolenoyl-CoA(4-)

metaR AMETt2m
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
modifier: MODEL1310110057#
fast: false
product: MODEL1310110057#
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000269
reversible: true
is: SBO:0000185
type: Reaction

metaM ptrc m
has only substance units: false
initial amount: NaN
notes: FORMULA: C4H14N2 CHARGE: 2 INCHI: InChI=1S/C4H12N2/c5-3-1-2-4-6/h1-6H2/p+2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
initial concentration: 1.0
is: HMDB01414
name: 1,4-butanediammonium
is: CHEBI:326268
type: Species
boundary condition: false
is: SBO:0000247
constant: false

metaR PTE3x
kinetic law: MODEL1310110057#
is: SBO:0000176
name: peroxisomal acyl-CoA thioesterase
modifier: MODEL1310110057#
product: MODEL1310110057#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
reactant: MODEL1310110057#
type: Reaction

metaM gly m
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
name: Glycine
has only substance units: false
is: SBO:0000247
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: C00037
is: CHEBI:15428
is: HMDB00123
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_67c68449_2d26_4595_8804_c735f8c45521
is: SBO:0000252
name: HAO2
is: Q9NYQ3
initial concentration: NaN
type: Species
is encoded by: hsa:51179
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true

metaR r2420
reactant: MODEL1310110057#
fast: false
reversible: true
type: Reaction
product: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110057#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7

metaM gd3 hs g
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28424
type: Species
boundary condition: false
name: GD3
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
has only substance units: false
constant: false
initial amount: NaN

metaM leuktrF4 e
is: CHEBI:27491
constant: false
has only substance units: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: leukotriene F4
type: Species
is: HMDB06465

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaR r1605
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR ILEtec
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
kinetic law: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
name: L-isoleucine transport via diffusion (extracellular to cytosol)
modifier: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000269

metaM urcan c
is: SBO:0000247
boundary condition: false
name: Urocanate
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
is: C00785
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00301
type: Species
is: CHEBI:17771
initial concentration: 1.0

metaM estrones c
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB01425
is: CHEBI:60050
notes: FORMULA: C18H21O5S CHARGE: -1 INCHI: InChI=1S/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/p-1/t14-,15-,16+,18+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00961 EHMN_ABBREVIATION: C02538
initial concentration: 1.0
name: estrone 3-sulfate(1-)

metaR r0549
kinetic law: MODEL1310110057#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.6.99.3
is version of: http://identifiers.org/ec-code/1.6.5.3
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
modifier: MODEL1310110057#
fast: false
reactant: MODEL1310110057#
product: MODEL1310110057#
reversible: true
is version of: http://identifiers.org/ec-code/6.1.1.17
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
is: SBO:0000176
type: Reaction

metaR EX ksi deg1 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I, degradation product 1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_518136c7_4327_48aa_87c8_20d450d27f31
type: Species
initial amount: NaN
is encoded by: hsa:1503
constant: false
initial concentration: NaN
is: P17812
name: CTPS1
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_81f12807_45c7_45d7_bae3_4a700102a164
initial amount: NaN
is: P14854
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
type: Species
name: COX6B1
is encoded by: hsa:1340

http://identifiers.org/biomodels.db/MODEL1310110057#_aa5d2a77_b214_42c2_8015_ac5438d1396c
is: SBO:0000252
name: NDUFB8
constant: false
initial concentration: NaN
has only substance units: false
is: O95169
initial amount: NaN
is encoded by: hsa:4714
boundary condition: true
type: Species

metaR r0330
fast: false
reactant: MODEL1310110057#
modifier: MODEL1310110057#
product: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
kinetic law: MODEL1310110057#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_9756657b_d307_4781_8281_9ba05c4f25ab
has only substance units: false
initial amount: NaN
is: P26439
initial concentration: NaN
constant: false
type: Species
name: HSD3B2
is encoded by: hsa:3284
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_9eceea9d_9a4b_490c_877a_0fdbc8e2e0d5
is: SBO:0000252
name: SLC2A2
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is: P11168
is encoded by: hsa:6514

metaM CE5867 e
name: N-acetyl-seryl-aspartyl-lysyl-proline
boundary condition: false
has only substance units: false
is: CHEBI:27485
notes: FORMULA: C20H32N5O9 CHARGE: -1 INCHI: InChI=1/C20H33N5O9/c1-11(27)22-14(10-26)18(31)24-13(9-16(28)29)17(30)23-12(5-2-3-7-21)19(32)25-8-4-6-15(25)20(33)34/h12-15,26H,2-10,21H2,1H3,(H,22,27)(H,23,30)(H,24,31)(H,28,29)(H,33,34)/p-1/t12-,13+,14-,15-/m0/s1 EHMN_ABBREVIATION: CE5867
is: SBO:0000247
constant: false
type: Species
is: HMDB02710
initial concentration: 1.0
initial amount: NaN

metaM dtmp c
is: CHEBI:26999
initial concentration: 1.0
type: Species
name: dTMP
constant: false
is: C00364
is: HMDB01227
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364

metaM cdp e
constant: false
is: CHEBI:58069
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP(3-)
has only substance units: false
initial amount: NaN
is: HMDB01546
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM 2ddecdicoa m
name: 2,6-dodecadienoylcoa
is: C05279
type: Species
is: HMDB11123
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false

metaM octd11ecoa c
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/5280771
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
name: 11-octadecenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110057#_cace01ca_a359_404e_9ad1_901f4791cea2
is: SBO:0000252
name: SDHD
constant: false
is encoded by: hsa:6392
has only substance units: false
boundary condition: true
is: O14521
type: Species
initial amount: NaN
initial concentration: NaN

metaM crm hs r
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
has only substance units: false
is: CHEBI:52639
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
name: N-acylsphingosine
type: Species

metaM ksi pre23 g
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:28067
initial concentration: 1.0
is: SBO:0000247
type: Species
name: keratan sulfate I biosynthesis, precursor 23

http://identifiers.org/biomodels.db/MODEL1310110057#_f3edb41f_3fbf_403c_976a_e375b4b70163
initial amount: NaN
type: Species
is encoded by: hsa:1716
is: SBO:0000252
constant: false
is: E5KSL6
initial concentration: NaN
name: DGUOK
has only substance units: false
boundary condition: true

metaM dha e
constant: false
boundary condition: false
name: glycerone
is: HMDB01882
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:16016
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
has only substance units: false

metaM glyc3p c
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: Glycerol 3-phosphate
is: CHEBI:57597
type: Species
is: HMDB00126
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
boundary condition: false
constant: false
is: C00093

metaM adrn e
has only substance units: false
name: adrenic acid
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
type: Species
is: CHEBI:53487
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
is: HMDB02226

metaR LALDO2x
product: MODEL1310110057#
name: D-Lactaldehyde:NAD+ 1-oxidoreductase
reversible: false
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF
modifier: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
is described by: ECO:0000269
fast: false
is: SBO:0000176

metaR GLNLASEer
is: SBO:0000176
fast: false
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
name: gluconolactonase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110057#

metaR GHMT2rm
type: Reaction
product: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.1
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
reversible: true
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
name: glycine hydroxymethyltransferase, reversible, mitochondrial
fast: false

metaR CEPTE
is: SBO:0000176
reversible: false
reactant: MODEL1310110057#
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (10390.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.8.2
name: ethanolamine phosphotransferase
fast: false

metaR LEUPHELAT2tc
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_aceae75c_2f70_4d54_8a38_17548e3b6c9c
constant: false
name: B3GNT8
is: Q7Z7M8
initial amount: NaN
is encoded by: hsa:374907
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252

W3 CDTF: Thu Aug 30 23:01:26 BST 2012

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaR ORPT
is version of: http://identifiers.org/ec-code/2.4.2.10
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
fast: false
reactant: MODEL1310110057#
modifier: MODEL1310110057#
name: orotate phosphoribosyltransferase
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110057#
product: MODEL1310110057#

metaM 3octdece1coa c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: 3-hydroxyoctadecenoylcoa
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
type: Species
is: HMDB13336
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_cbec6fa2_9ea2_4c00_a2c5_4771bcfce462
is encoded by: hsa:113452
name: TMEM54
is: Q969K7
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_6e3c1f9c_6f5e_400b_b771_106e1601871a
is: Q9Y2A9
initial concentration: NaN
name: B3GNT3
has only substance units: false
is encoded by: hsa:10331
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false

metaR DOLPMT3 Ler
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.260
reversible: false
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110057#
reactant: MODEL1310110057#

metaR TREHe
product: MODEL1310110057#
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
reactant: MODEL1310110057#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.2.1.28
name: alpha,alpha-trehalase
reversible: false
type: Reaction
is: SBO:0000176

metaM cdp c
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP
type: Species
is: CHEBI:58069
is: C00112
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
is: HMDB01546
initial concentration: 1.0
boundary condition: false

metaM dtmp e
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
constant: false
initial concentration: 1.0
is: HMDB01227
initial amount: NaN
is: SBO:0000247
name: dTMP(2-)
boundary condition: false
has only substance units: false
is: CHEBI:26999
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_18a90843_22e4_4fe6_add9_0558cd5999f6
is: SBO:0000252
initial amount: NaN
name: PDE9A
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
is encoded by: hsa:5152

http://identifiers.org/biomodels.db/MODEL1310110057#_75184f11_d7de_4f71_9b89_2aa2b17d202c
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:55902
name: ACSS2
type: Species
initial concentration: NaN
is: Q5QPH3

metaR EICOSTETCRNt
fast: false
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110057#
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110057#_c37fed8b_5cad_4fcd_b2e1_b99e4ecc2c02
name: ENTPD2
is encoded by: hsa:954
is: Q5SPY7
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_3b1271dd_fb83_46bd_8282_a0aa11ac2abd
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial concentration: NaN
name: DBH
is: P09172
initial amount: NaN
is encoded by: hsa:1621

metaR G14T6g
reactant: MODEL1310110057#
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110057#
fast: false
is: SBO:0000176
modifier: MODEL1310110057#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is described by: ECO:0000000
reversible: false

W3 CDTF: Thu Aug 30 23:01:26 BST 2012

metaR FAS120COA
product: MODEL1310110057#
is: SBO:0000176
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
fast: false
modifier: MODEL1310110057#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.85
name: fatty-acyl-CoA synthase (n-C12:0CoA)
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_af61b804_f932_4f9f_a7be_940ef81b358a
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:79053
name: ALG8

metaR r1608
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR FAOXC150m
name: Beta oxidation of long chain fatty acid (odd chain)
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ
is described by: ECO:0000269
fast: false
type: Reaction
reactant: MODEL1310110057#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110057#

metaR r0331
product: MODEL1310110057#
type: Reaction
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
fast: false
kinetic law: MODEL1310110057#
reversible: false
modifier: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000176

metaR ASNCYSNaEx
product: MODEL1310110057#
kinetic law: MODEL1310110057#
type: Reaction
reversible: false
is: SBO:0000185
fast: false
modifier: MODEL1310110057#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110057#
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)

http://identifiers.org/biomodels.db/MODEL1310110057#_8310baab_0c08_48f9_a52b_421530b69be7
initial concentration: NaN
constant: false
has part: Q96I99
type: Species
has part: P53597
boundary condition: true
is encoded by: hsa:8802
initial amount: NaN
name: SUCLG2:SUCLG1
is encoded by: hsa:8801
is: SBO:0000297
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_e523694b_9476_4c16_8b67_8c6d68512955
is encoded by: hsa:4728
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
name: NDUFS8
is: O00217

metaR r1609
is described by: ECO:0000000
reactant: MODEL1310110057#
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110057#

metaR r0545
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is described by: ECO:0000000
fast: false
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
product: MODEL1310110057#

metaR FAOXC226C225m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

metaR r0817
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.41
reversible: true
fast: false
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
product: MODEL1310110057#
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110057#_21194155_52c9_4626_b2eb_ce90ea75ce36
is: SBO:0000252
name: NSF
boundary condition: true
is: P46459
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:4905
initial amount: NaN
constant: false

metaM h2o x
boundary condition: false
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
is: C00001
constant: false
initial concentration: 1.0
is: CHEBI:15377
is: HMDB02111
type: Species
name: H2O
initial amount: NaN

metaR ASPGLUm
modifier: MODEL1310110057#
is: SBO:0000185
fast: false
reactant: MODEL1310110057#
name: aspartate-glutamate mitochondrial shuttle
notes: GENE_ASSOCIATION: (8604.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reversible: true

metaM udpgal c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:58439
type: Species
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
boundary condition: false
is: HMDB00302
name: UDP-D-galactose(2-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_fb5ccfae_2a78_4493_9823_81e1940e1d05
is: SBO:0000252
type: Species
is encoded by: hsa:3418
constant: false
initial amount: NaN
is: P48735
has only substance units: false
initial concentration: NaN
name: IDH2
boundary condition: true

metaR EX glyc S LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (S)-Glycerate exchange
type: Reaction

metaR AG13T13g
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110057#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110057#
is described by: ECO:0000000
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110057#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110057#_391b28f9_ea8f_44a8_bf99_293a7d771713
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: SLC28A3
type: Species
is: Q9HAS3
is encoded by: hsa:64078

metaM HC02175 e
initial concentration: 1.0
constant: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
is: SBO:0000247
name: caprate
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:27689

http://identifiers.org/biomodels.db/MODEL1310110057#_a20ade76_b860_4c55_b277_c033edddc9d6
name: SPTLC2
boundary condition: true
is: O15270
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:9517
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_131cf146_f7c1_45f1_a41a_bfb46bab690e
name: LDHAL6A
has only substance units: false
is: Q6ZMR3
initial amount: NaN
is encoded by: hsa:160287
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species

metaR FUCASE2ly
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
product: MODEL1310110057#
reversible: false
name: alpha-fucosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.51
modifier: MODEL1310110057#
fast: false

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaR EX c6crn
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hexanoyl carnitine
type: Reaction

metaM gly c
is: HMDB00123
initial concentration: 1.0
boundary condition: false
is: C00037
notes: FORMULA: C2H5NO2 CHARGE: 0
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: Glycine
is: CHEBI:3339
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_d7dd0ccf_ab48_4979_9052_cf28e4a29775
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5208
type: Species
boundary condition: true
is: O60825
constant: false
initial amount: NaN
name: PFKFB2
is: SBO:0000252

metaR ECOAH1m
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
product: MODEL1310110057#
is: SBO:0000176
is described by: ECO:0000304
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.18
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
modifier: MODEL1310110057#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110057#_8ec1f61d_ace4_4a79_8032_b8571912e4eb
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: A8K8P8
has only substance units: false
is encoded by: hsa:2530
constant: false
initial amount: NaN
name: FUT8
type: Species

http://identifiers.org/biomodels.db/MODEL1310110057#_a44cbcfa_fd34_4729_848d_00d982e53f95
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:8801
is: Q96I99
boundary condition: true
initial concentration: NaN
name: SUCLG2

metaM gal14acglcgalgluside hs g
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17103
name: Lactoneotetraosylceramide
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110057#_2f53835a_e17e_4302_b2f1_1da49ae9a3d9
has only substance units: false
is: P19961
is encoded by: hsa:280
is: SBO:0000252
name: AMY2B
type: Species
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR GLYCTO1p
fast: false
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110057#
type: Reaction
name: Glycolate oxidase, peroxisome
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
reversible: false
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
is version of: http://identifiers.org/ec-code/1.1.3.15

metaR r0434
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
fast: false
reversible: true
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
reactant: MODEL1310110057#
product: MODEL1310110057#
modifier: MODEL1310110057#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110057#

metaR CYANtm
fast: false
name: Cyanide transport via diffusion (mitochondrial)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
product: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: true
is: SBO:0000185
reactant: MODEL1310110057#
type: Reaction
is described by: ECO:0000000

metaR FAOXC123m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

metaR S6T10g
product: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110057#
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110057#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaM imp c
is: C00130
initial amount: NaN
is: HMDB00175
is: SBO:0000247
type: Species
name: IMP
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
boundary condition: false
constant: false
is: CHEBI:58053
initial concentration: 1.0
has only substance units: false

metaR LCTStg
is described by: ECO:0000000
product: MODEL1310110057#
name: lactose transport from Golgi to extracellular (via vesicle)
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:this reaciton is only found in lactating mammary cells NCD

metaR FACOAL184
is: SBO:0000176
kinetic law: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
modifier: MODEL1310110057#
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
name: fatty-acid--CoA ligase
product: MODEL1310110057#
reversible: true

metaM 4abutn m
is: CHEBI:58264
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
name: 4-ammoniobutanal
is: HMDB01080
type: Species

metaM ksii core2 pre2 g
has only substance units: false
initial concentration: 1.0
type: Species
is: C00130
initial amount: NaN
is: HMDB00175
is: CHEBI:58053
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C39H63N3O28X CHARGE: -1
name: keratan sulfate II biosynthesis, precursor 2

metaM 3hddcoa m
type: Species
initial concentration: 1.0
is: SBO:0000247
name: (S)-3-Hydroxydodecanoyl-CoA
is: HMDB11123
is: C05279
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
initial amount: NaN

metaM udpgal e
is: HMDB00302
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
has only substance units: false
type: Species
constant: false
name: UDP-D-galactose(2-)
initial concentration: 1.0
is: CHEBI:58439

metaR TYMSFt
name: Tyramine O-sulfate transport (diffusion)
fast: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
reversible: false
is: SBO:0000185
product: MODEL1310110057#
is described by: ECO:0000000
reactant: MODEL1310110057#
type: Reaction

metaR ACCOAgt
is: SBO:0000185
modifier: MODEL1310110057#
type: Reaction
name: acetyl-coa transport
product: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000269
reversible: true

metaM ptrc e
constant: false
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
type: Species
is: C00134
has only substance units: false
initial amount: NaN
boundary condition: false
name: Putrescine
is: SBO:0000247
initial concentration: 1.0
is: HMDB01414
is: CHEBI:326268

metaM HC02175 c
is: CHEBI:27689
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
initial amount: NaN
name: caprate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_a7770ac0_d865_4e4e_89b1_2d41c2665d0d
is encoded by: hsa:10087
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
name: COL4A3BP
is: Q9Y5P4
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_e37eebaf_5567_463f_9feb_ec878a689377
constant: false
type: Species
is: O95436
name: SLC34A2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10568
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_53f6c32a_3f3f_4f27_9d70_6c1818092174
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
name: SLC1A5
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q15758
is encoded by: hsa:6510

metaR r0437
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
modifier: MODEL1310110057#
reactant: MODEL1310110057#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is version of: http://identifiers.org/ec-code/4.1.2.13
product: MODEL1310110057#
reversible: true

metaR r0812
modifier: MODEL1310110057#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.3.1.41
type: Reaction
fast: false
product: MODEL1310110057#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
is: SBO:0000185
reversible: true
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_d963b78f_312a_4b7f_946d_bc0a1e0716cb
is: SBO:0000252
boundary condition: true
name: SLC43A1
constant: false
initial amount: NaN
is: O75387
initial concentration: NaN
is encoded by: hsa:8501
has only substance units: false
type: Species

metaM 2ddecdicoa x
is: SBO:0000247
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
constant: false
is: C05279
initial concentration: 1.0
name: 2,6-dodecadienoylcoa
has only substance units: false
boundary condition: false
is: HMDB11123
type: Species
initial amount: NaN

metaM gly e
is: HMDB00123
is: C00037
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C2H5NO2 CHARGE: 0
type: Species
initial amount: NaN
is: CHEBI:3339
constant: false
has only substance units: false
name: Glycine

http://identifiers.org/biomodels.db/MODEL1310110057#_f7c50466_3764_4f1d_a84b_77314e6c18aa
name: PLA2G2A
is: SBO:0000252
type: Species
is: P14555
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5320
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_572ec285_2054_410c_9316_182773e59c49
is encoded by: hsa:686
type: Species
boundary condition: true
initial amount: NaN
name: BTD
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is: P43251

metaM gtp n
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has only substance units: false
is: CHEBI:37565
initial amount: NaN
type: Species
name: GTP(4-)
is: HMDB01273
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110057#_a6d94fc0_68e4_4190_b445_f0c658079668
boundary condition: true
initial concentration: NaN
type: Species
is: B4DUY1
name: STARD3
has only substance units: false
initial amount: NaN
is encoded by: hsa:10948
constant: false
is: SBO:0000252

metaM g2m8mpdol L r
has only substance units: false
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false
notes: FORMULA: C1900H3128N20O720P20 CHARGE: -20
initial concentration: 1.0
type: Species
is: C05870
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_dd256783_4a91_4017_9032_3d9c361fbbbc
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: PDE9A
is encoded by: hsa:5152

metaR r0813
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110057#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.9
fast: false
product: MODEL1310110057#

metaR r0541
modifier: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000176
reactant: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
type: Reaction
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.5
fast: false
kinetic law: MODEL1310110057#

metaR B3GNT35g
is: SBO:0000176
reversible: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_06143cb9_c251_48f3_b061_d5a121d75786
has part: P23378
initial concentration: NaN
is encoded by: hsa:2731
is: SBO:0000297
is encoded by: hsa:2653
type: Species
has part: P23434
name: DLD:GCSH:GLDC:AMT
has part: P48728
initial amount: NaN
is encoded by: hsa:275
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_99ef3896_14a3_4ed3_98b4_3a302abb4814
is: B7Z763
name: AMPD3
is encoded by: hsa:272
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM udpgal g
boundary condition: false
type: Species
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
has only substance units: false
constant: false
name: UDP-D-galactose(2-)
is: CHEBI:58439
is: HMDB00302
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR G5SADrm
is: SBO:0000176
product: MODEL1310110057#
fast: false
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
reversible: true
type: Reaction

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaR ADRNCRNt
type: Reaction
reactant: MODEL1310110057#
is described by: ECO:0000000
fast: false
product: MODEL1310110057#
name: transport into the mitochondria (carnitine)
reversible: false
is: SBO:0000185
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (788.1) or (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR GHMT2r
reversible: true
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.1.2.1
modifier: MODEL1310110057#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110057#
type: Reaction
name: glycine hydroxymethyltransferase, reversible
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
fast: false
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_b2999669_e1f7_409b_8ff6_81d844490adf
is: SBO:0000252
name: SLC4A2
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:6522
initial concentration: NaN
initial amount: NaN
is: F8W682
type: Species

metaM HC01401 x
constant: false
initial concentration: 1.0
boundary condition: false
name: (S)-3-Hydroxydodecanoyl-CoA
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:27668
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
has only substance units: false

metaM pail hs c
initial concentration: 1.0
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
has only substance units: false
boundary condition: false
is: CHEBI:57880
initial amount: NaN
type: Species
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: SBO:0000247
constant: false

metaR FAOXTC182TC162m
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C18:2-->C16:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_6c706b96_1db2_4290_bf93_9224e0a0b083
type: Species
is: P14555
name: PLA2G2A
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:5320
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_77720a0c_3238_4748_ad17_319aaae91a63
name: IDH1
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is: O75874
is encoded by: hsa:3417
has only substance units: false
initial concentration: NaN
type: Species

metaR NCNt
is described by: ECO:0000269
reactant: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
name: Na+/Ca2+-NH4+ exchange
fast: false
modifier: MODEL1310110057#
is: SBO:0000185
product: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_5957da19_769b_4713_bf36_2cbebe7bae54
is encoded by: hsa:5464
initial concentration: NaN
is: Q15181
is: SBO:0000252
constant: false
initial amount: NaN
name: PPA1
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_4a799a25_80a2_4ea1_b34c_c4d23beb095b
is encoded by: hsa:8399
boundary condition: true
is: O15496
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: PLA2G10
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_47204df9_e807_46c7_986f_ac80a95f1cee
name: PDE9A
type: Species
boundary condition: true
constant: false
is encoded by: hsa:5152
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR r2310
reversible: true
reactant: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110057#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110057#

metaR SO4t4 2
fast: false
type: Reaction
name: sulfate transport via sodium symport
product: MODEL1310110057#
is described by: ECO:0000269
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
reversible: true
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
modifier: MODEL1310110057#
is: SBO:0000185

metaR PPAt
product: MODEL1310110057#
fast: false
reversible: false
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
name: Propionate transport, diffusion
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_metaM_galacgalfucgalacglcgal14acglcgalgluside_hs_g
constant: false
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:26174
initial amount: NaN
notes: FORMULA: C78H135N4O46FULLRCO CHARGE: 0
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1

metaR GTHDH
product: MODEL1310110057#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
is described by: ECO:0000134
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
reversible: false
name: Glutathione dehydrogenase (dehydroascorbate reductase)
type: Reaction

metaR HTDCRNe
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-tetradecanoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_504cd405_9ab9_45a6_89e0_868f1625e482
is encoded by: hsa:AA576959
initial amount: NaN
type: Species
is: SBO:0000252
name: _AA576959_1_c
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_da6a6db3_0627_4151_85c9_1bd4319afb29
type: Species
is encoded by: hsa:7991
name: TUSC3
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR PGLer
is version of: http://identifiers.org/ec-code/1.1.1.47
is: SBO:0000176
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
fast: false
product: MODEL1310110057#
type: Reaction
kinetic law: MODEL1310110057#
is described by: ECO:0000269
modifier: MODEL1310110057#
reversible: false
name: 6-phosphogluconolactonase, endoplasmic reticulum
reactant: MODEL1310110057#

metaM gtp m
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: SBO:0000247
initial amount: NaN
is: HMDB01273
name: GTP
is: C00044
type: Species
is: CHEBI:37565
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

metaR r0224
type: Reaction
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
reactant: MODEL1310110057#
product: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
is described by: ECO:0000000
is: SBO:0000176
reversible: false

metaR FK
modifier: MODEL1310110057#
is described by: ECO:0000000
reversible: false
product: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.7.1.52
kinetic law: MODEL1310110057#
name: Fucokinase
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110057#_973e3457_56c7_4e9b_9b7f_d64ce65f5f2d
has only substance units: false
is encoded by: hsa:3038
is: Q96RV2
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: HAS3
constant: false
boundary condition: true

metaR FAOXC226C225x
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)x
type: Reaction

metaR C8CRNe
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octanoyl carnitine into the extra cellular space
type: Reaction

metaM leuktrF4 c
is: HMDB06465
initial amount: NaN
name: leukotriene F4
initial concentration: 1.0
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
type: Species
boundary condition: false
constant: false
is: CHEBI:27491
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_ad26e737_c687_45d4_baf8_0510cdb4ab52
constant: false
has only substance units: false
boundary condition: true
is: Q13733
type: Species
is: SBO:0000252
is encoded by: hsa:480
initial concentration: NaN
initial amount: NaN
name: ATP1A4

metaR ACGPID
is: SBO:0000176
name: N-acetylglucosaminylphosphatidylinositol deacetylase
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.89
reactant: MODEL1310110057#
modifier: MODEL1310110057#
is described by: ECO:0000269
kinetic law: MODEL1310110057#
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
fast: false
product: MODEL1310110057#

metaR TDCRNe
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of myristoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_6dd944c3_e3b3_4677_ad85_c86c808b60cc
name: ALG1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:56052
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is: Q9BT22

metaR ACGAMPM
reversible: true
name: phosphoacetylglucosamine mutase
type: Reaction
modifier: MODEL1310110057#
fast: false
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
is version of: http://identifiers.org/ec-code/5.4.2.3
kinetic law: MODEL1310110057#
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_5ae436c9_1737_4068_b27b_1bd795963cfa
initial concentration: NaN
is encoded by: hsa:55902
is: Q5QPH3
name: ACSS2
type: Species
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR PPItx
reversible: true
type: Reaction
kinetic law: MODEL1310110057#
name: Diphosphate transporter, peroxisome
reactant: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110057#
is described by: ECO:0000000
fast: false

metaR COAtg
product: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110057#
reversible: true
type: Reaction
fast: false
name: CoA transport in Golgi via diffusion
kinetic law: MODEL1310110057#
is: SBO:0000185

metaM 4hglusa m
is: HMDB06556
boundary condition: false
has only substance units: false
name: L-4-hydroxyglutamic semialdehyde
initial amount: NaN
type: Species
is: CHEBI:27809
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_0bf776ac_7b34_41ac_b984_d1065afd212e
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:6240
is: P23921
name: RRM1
initial concentration: NaN
type: Species

metaM crm hs g
initial amount: NaN
boundary condition: false
is: CHEBI:52639
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: N-acylsphingosine
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195

metaM h2o r
is: C00001
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
name: H2O
is: HMDB02111
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:15377
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110057#_67fb91c8_2e60_40e6_8f2c_ec54eaf16177
name: _AI373818_1_m
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI373818
boundary condition: true
constant: false

metaR r0013
fast: false
is: SBO:0000176
type: Reaction
reversible: false
reactant: MODEL1310110057#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110057#
name: beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.52 Confidence Level: 0 AUTHORS: PMID:10481922,PMID:2423070,PMID:6219664,PMID:758959 NOTES:
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_838d4b74_0623_456a_9da2_8e23a27ea720
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:5281
has only substance units: false
name: PIGF
is: Q07326
type: Species

metaM dtmp m
is: CHEBI:26999
has only substance units: false
is: HMDB01227
is: C00364
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
name: dTMP
constant: false
initial amount: NaN
boundary condition: false

metaR r2312
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110057#
product: MODEL1310110057#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110057#
reversible: true

metaR PRASCS
fast: false
is: SBO:0000176
reactant: MODEL1310110057#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110057#
reversible: true
type: Reaction
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is version of: http://identifiers.org/ec-code/6.3.2.6
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase

metaM acgpail hs c
boundary condition: false
is: CHEBI:57265
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
type: Species
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0

metaR r0339
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.22
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
product: MODEL1310110057#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.2.2
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR SPHS1Pte
type: Reaction
name: sphingosine-1-phosphate transport
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110057#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
reactant: MODEL1310110057#
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_1352c5af_fbfb_42cf_9834_bad749a4e8dc
is: SBO:0000252
constant: false
is: P80404
has only substance units: false
is encoded by: hsa:18
name: ABAT
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110057#_32454f7a_09a3_49a7_a853_3324b9214d29
has only substance units: false
is encoded by: hsa:X63359
type: Species
initial amount: NaN
name: _X63359_1_c
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252

metaM lnlncgcoa r
has only substance units: false
type: Species
name: gamma-linolenoyl-CoA(4-)
initial concentration: 1.0
is: HMDB06368
is: SBO:0000247
is: CHEBI:57363
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035

http://identifiers.org/biomodels.db/MODEL1310110057#_3caa99c6_16a7_492a_8cd7_a7b55e2e632c
name: GCSH
is: P23434
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2653
constant: false

metaM ctp e
type: Species
is: SBO:0000247
name: CTP(4-)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: HMDB00082
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:37563

http://identifiers.org/biomodels.db/MODEL1310110057#_3c2216a6_8dd9_4e22_9d60_f879ff19a435
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:5152
constant: false
initial amount: NaN
is: SBO:0000252
name: PDE9A

metaR PAIL4P HStn
kinetic law: MODEL1310110057#
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110057#
fast: false
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110057#

metaR r2311
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reversible: true
is: SBO:0000185
reactant: MODEL1310110057#
product: MODEL1310110057#
fast: false
kinetic law: MODEL1310110057#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
is described by: ECO:0000000

metaM dttp c
has only substance units: false
name: dTTP
is: C00459
boundary condition: false
is: CHEBI:37568
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: HMDB01342
is: SBO:0000247

metaR THYOXt2
product: MODEL1310110057#
name: T4 transport via facilitated diffusion
fast: false
reactant: MODEL1310110057#
kinetic law: MODEL1310110057#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
type: Reaction
modifier: MODEL1310110057#
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110057#_19ab58a8_f2f6_43cf_b6ae_9d160f69afc1
type: Species
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:84105
name: PCBD2
is: SBO:0000252
initial amount: NaN
is: Q9H0N5

metaR DCSPTN1CRNt
kinetic law: MODEL1310110057#
modifier: MODEL1310110057#
reactant: MODEL1310110057#
reversible: false
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110057#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000269

metaR BUTt2m
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110057#
fast: false
reversible: true
kinetic law: MODEL1310110057#
name: Butyrate mitochondrial transport via proton symport, reversible
product: MODEL1310110057#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110057#

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaM tetde5coa x
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
is: SBO:0000247
name: 5-tetradecenoylcoa
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: HMDB13109

metaM 3odcoa m
is: CHEBI:28528
type: Species
is: HMDB03939
is: SBO:0000247
initial concentration: 1.0
name: 3-Oxodecanoyl-CoA
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
initial amount: NaN

metaM ctp n
is: SBO:0000247
has only substance units: false
is: CHEBI:37563
constant: false
is: HMDB00082
type: Species
initial amount: NaN
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
boundary condition: false
initial concentration: 1.0
name: CTP(4-)

metaM m7masnB r
boundary condition: false
initial amount: NaN
constant: false
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
is: C05881
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C64H107N2O50X CHARGE: 0
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110057#_34833280_8c62_46d8_a7e8_e6715c28d142
initial concentration: NaN
type: Species
has only substance units: false
name: SLC22A5
boundary condition: true
is encoded by: hsa:6584
is: O76082
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110057#_5bcd66fc_f95f_42b6_9365_dd1194f80f24
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:6508
initial amount: NaN
name: SLC4A3
is: SBO:0000252
type: Species
constant: false
is: P48751

metaR r0791
reactant: MODEL1310110057#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110057#
type: Reaction
product: MODEL1310110057#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
kinetic law: MODEL1310110057#
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38

metaM etfox m
notes: FORMULA: R CHARGE: 0
is: SBO:0000247
is: CHEBI:17263
is: HMDB00145
type: Species
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
name: Electron transfer flavoprotein oxidized
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110057#_8e96ceb8_a3ea_42ea_807d_e7305cd91342
has only substance units: false
boundary condition: true
initial concentration: NaN
is: B7Z6S9
constant: false
is encoded by: hsa:2629
initial amount: NaN
type: Species
name: GBA
is: SBO:0000252

metaR GLYt2r
is: SBO:0000185
kinetic law: MODEL1310110057#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reversible: true
reactant: MODEL1310110057#
is described by: ECO:0000304
name: glycine reversible transport via proton symport
modifier: MODEL1310110057#
product: MODEL1310110057#

metaR HPDCACRNCPT2
fast: false
modifier: MODEL1310110057#
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reversible: false
is: SBO:0000176
name: heptadecanoate transport into the mitochondria
reactant: MODEL1310110057#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
type: Reaction

metaR C10CRNe
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decanoyl carnitine into extra cellular space
type: Reaction

metaR SUBERCACT
kinetic law: MODEL1310110057#
product: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberyl carnitine into cytosol
type: Reaction

metaR r0647
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
is: SBO:0000176
name: Spontaneous reaction
reversible: true
reactant: MODEL1310110057#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110057#
product: MODEL1310110057#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110057#_75f2ebc3_5b27_4785_a461_5f6caee821bc
is: P31645
boundary condition: true
is encoded by: hsa:6532
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: SLC6A4

metaR CSNAT2m
is described by: ECO:0000000
kinetic law: MODEL1310110057#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.7
reversible: true
fast: false
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
reactant: MODEL1310110057#
name: carnitine O-aceyltransferase, mitochondrial
type: Reaction
product: MODEL1310110057#

http://identifiers.org/biomodels.db/MODEL1310110057#_b98f616e_701f_4fce_908f_7e7b872f1630
type: Species
initial amount: NaN
is: SBO:0000252
is: E9PB82
constant: false
has only substance units: false
name: HSD17B4
initial concentration: NaN
is encoded by: hsa:3295
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110057#_d2caffca_a3e7_455d_a707_77285d587f74
is: O43280
is: SBO:0000252
name: TREH
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:11181

metaR r0792
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110057#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
kinetic law: MODEL1310110057#
type: Reaction
reversible: true
reactant: MODEL1310110057#
is: SBO:0000176
product: MODEL1310110057#
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110057#_a8a0b4b7_d8bf_48ff_8779_21a288ba93e1
name: ME1
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:4199
has only substance units: false
is: P48163
boundary condition: true
initial concentration: NaN

metaM glyc e
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:17754
boundary condition: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: C00116
name: Glycerol
initial amount: NaN
is: HMDB00131

http://identifiers.org/biomodels.db/MODEL1310110057#_3098339a_26ca_41ab_97d3_9c95e86e1acf
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:51227
initial amount: NaN
has only substance units: false
name: PIGP
boundary condition: true

metaR DPHMBDCm
is described by: ECO:0000000
type: Reaction
product: MODEL1310110057#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212,PMID:7380842 NOTES:enzyme has not been identified yet IT
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate decarboxylation
fast: false
reversible: false
kinetic law: MODEL1310110057#
is: SBO:0000176
reactant: MODEL1310110057#

metaR EX c4crn
kinetic law: MODEL1310110057#
reactant: MODEL1310110057#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for butyryl carnitine
type: Reaction

metaR r2005
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110057#
type: Reaction
reactant: MODEL1310110057#
modifier: MODEL1310110057#
kinetic law: MODEL1310110057#
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15