metaR R group phosphotase 1
product: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
name: R group phosphotase 1
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000176
type: Reaction

metaR r0669
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
is described by: ECO:0000000
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
type: Reaction
product: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000176
reactant: MODEL1310110056#

metaR r0556
reactant: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
fast: false
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
is version of: http://identifiers.org/ec-code/1.14.19.1
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#
is: SBO:0000176

metaR DOLPMT4 Ler
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000185
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
is described by: ECO:0000000
kinetic law: MODEL1310110056#
type: Reaction
reversible: false
product: MODEL1310110056#
reactant: MODEL1310110056#

metaR KSII CORE4t
type: Reaction
reactant: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: keratan sulfate II (core4) transport, golgi to extracellular
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110056#
fast: false

metaM urate c
is: SBO:0000247
initial concentration: 1.0
is: C00366
type: Species
constant: false
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
name: Urate
boundary condition: false
is: HMDB00289
has only substance units: false
initial amount: NaN
is: CHEBI:17775

metaR P4501B1r
type: Reaction
reversible: false
name: cytochrome P450 1B1
notes: GENE_ASSOCIATION: (1545.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:8910454 NOTES:_4 hydroxylation of 17 beta estradiol NJ
modifier: MODEL1310110056#
fast: false
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.14.14.1
kinetic law: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_63b4a375_a9ab_4e81_8298_a9664e46f3ed
constant: false
is encoded by: hsa:8875
is: O95498
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: VNN2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_4ab36f1e_0263_45d6_85de_f4b71a7cbe82
boundary condition: true
type: Species
is encoded by: hsa:54344
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q9P2X0
name: DPM3

metaR r2064
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000185
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110056#
modifier: MODEL1310110056#
type: Reaction

metaM crvnc c
constant: false
type: Species
is: HMDB02183
initial concentration: 1.0
is: CHEBI:36005
notes: FORMULA: C22H31O2 CHARGE: -1
boundary condition: false
name: cervonic acid, C22:6 n-3
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR r0668
product: MODEL1310110056#
kinetic law: MODEL1310110056#
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.2.19
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
reactant: MODEL1310110056#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110056#
fast: false

metaM g1p c
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
is: CHEBI:58601
is: SBO:0000247
is: C00103
initial concentration: 1.0
constant: false
name: D-Glucose 1-phosphate
boundary condition: false
is: HMDB01586
initial amount: NaN
has only substance units: false

metaM ocdececrn m
name: 11-octadecenoyl carnitine
is: HMDB06351
boundary condition: false
initial amount: NaN
notes: FORMULA: C25H47NO4 CHARGE: 0
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR GALASE11ly
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110056#
reversible: false
modifier: MODEL1310110056#
name: beta-galactosidase, lysosomal
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR HSAT2ly
reactant: MODEL1310110056#
type: Reaction
reversible: false
kinetic law: MODEL1310110056#
is: SBO:0000185
fast: false
product: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
name: heparan-glucosaminide N-acetyltransferase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110056#_54afcd47_f30e_44f0_9513_9d7ef49f95b9
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:790
is: P27708
initial amount: NaN
name: CAD

metaR 3MOPt2im
kinetic law: MODEL1310110056#
product: MODEL1310110056#
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
reactant: MODEL1310110056#
fast: false
type: Reaction
reversible: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM

metaR ASNALANaEx
reactant: MODEL1310110056#
reversible: false
is described by: ECO:0000269
name: L-alanine/L-asparagine Na-dependent exchange (Asn-L in)
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
kinetic law: MODEL1310110056#
fast: false
product: MODEL1310110056#
modifier: MODEL1310110056#

metaR NACHEXA9ly
name: beta-N-acetylhexosaminidase A, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is: SBO:0000176
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110056#
reversible: false
modifier: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
fast: false

metaM occoa x
name: Octanoyl-CoA (n-C8:0CoA)
initial amount: NaN
is: CHEBI:57386
constant: false
has only substance units: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
type: Species
boundary condition: false
initial concentration: 1.0
is: C01944
is: HMDB01070
is: SBO:0000247

metaR GALNTg
name: GalNAc transferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.41
modifier: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
kinetic law: MODEL1310110056#
fast: false
type: Reaction
reactant: MODEL1310110056#

metaM tcynt e
constant: false
initial concentration: 1.0
name: thiocyanate
initial amount: NaN
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: HMDB01453
is: CHEBI:18022
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_d42d976b_1cd5_4c93_8670_8a79db7bd92b
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:6547
is: SBO:0000252
name: SLC8A3
is: P57103

http://identifiers.org/biomodels.db/MODEL1310110056#_1e1ca343_6cdb_4089_8b1b_40f701d5da91
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:29925
type: Species
initial concentration: NaN
name: GMPPB

metaR GLUDym
reactant: MODEL1310110056#
product: MODEL1310110056#
reversible: true
is version of: http://identifiers.org/ec-code/1.4.1.3
modifier: MODEL1310110056#
is: SBO:0000176
kinetic law: MODEL1310110056#
is described by: ECO:0000269
name: glutamate dehydrogenase (NADP), mitochondrial
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
type: Reaction
fast: false

metaR RE2677G
kinetic law: MODEL1310110056#
is described by: ECO:0000000
reversible: false
product: MODEL1310110056#
fast: false
is: SBO:0000176
name: RE2677
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:
type: Reaction
reactant: MODEL1310110056#

metaM urate e
is: HMDB00289
is: C00366
type: Species
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
boundary condition: false
has only substance units: false
is: CHEBI:17775
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
name: Urate

http://identifiers.org/biomodels.db/MODEL1310110056#_9c74660a_0f41_42a0_8ca5_cca596bd7fd6
is: SBO:0000252
boundary condition: true
constant: false
name: SLC25A18
is encoded by: hsa:83733
has only substance units: false
initial concentration: NaN
is: Q9H1K4
initial amount: NaN
type: Species

metaM ksi deg41 l
is: SBO:0000247
is: CHEBI:12936
has only substance units: false
boundary condition: false
name: keratan sulfate I, degradation product 41
constant: false
is: HMDB00143
notes: FORMULA: C34H58N2O26 CHARGE: 0
initial amount: NaN
type: Species
initial concentration: 1.0

metaM crvnc e
type: Species
is: HMDB02183
is: CHEBI:36005
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C22H31O2 CHARGE: -1
initial amount: NaN
constant: false
name: cervonic acid, C22:6 n-3
has only substance units: false

metaR SUBERICACT
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of suberic acid for formation of suberyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_047f2b92_c5a1_4872_aedf_d43f12e1d8e6
initial amount: NaN
name: _H77542_1_c
type: Species
is encoded by: hsa:H77542
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_ef4af6a7_11ed_4470_a73a_6e89df0393ee
initial amount: NaN
type: Species
is: P22033
is: SBO:0000252
initial concentration: NaN
name: MUT
is encoded by: hsa:4594
constant: false
has only substance units: false
boundary condition: true

metaR BILDGLCURt
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
reversible: true
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
product: MODEL1310110056#
fast: false

metaR FAOXC142C122m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_9c211ce2_2160_4489_9646_f3d0ac185b25
name: NMNAT2
has only substance units: false
type: Species
is encoded by: hsa:23057
is: SBO:0000252
initial amount: NaN
is: Q9BZQ4
boundary condition: true
initial concentration: NaN
constant: false

metaR ASPGLUm
reactant: MODEL1310110056#
name: aspartate-glutamate mitochondrial shuttle
is: SBO:0000185
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
fast: false
product: MODEL1310110056#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8604.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: true

metaR AICARte
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110056#
product: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110056#
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
reversible: true
is: SBO:0000185

metaM Ssq23epx r
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
is: CHEBI:15441
name: (S)-2,3-epoxysqualene
is: HMDB01188
constant: false
boundary condition: false
has only substance units: false

metaR CYSSNAT5tc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_9c3ab0d4_ee61_44ab_a41e_8a1edc08cba3
constant: false
name: ACSM1
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:116285
initial concentration: NaN
boundary condition: true
is: Q08AH1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_b085f878_17c3_4ed6_9568_4b993e71661d
name: SLC43A2
has only substance units: false
initial amount: NaN
is encoded by: hsa:124935
is: SBO:0000252
is: Q8N370
constant: false
initial concentration: NaN
boundary condition: true
type: Species

metaM lnlccrn m
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
name: Linoleyl carnitine
type: Species
is: HMDB06469
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR FAOXC102C103x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)x
type: Reaction

metaR HACD9m
is version of: http://identifiers.org/ec-code/1.1.1.35
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
type: Reaction
is: SBO:0000176
reversible: true
modifier: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
fast: false
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#

metaM 3ttetddcoa m
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
name: 3-hydroxy trans5,8tetradecadienoyl coa
is: HMDB02014
boundary condition: false

metaM nadph x
type: Species
is: HMDB00221
has only substance units: false
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate - reduced
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
constant: false
is: C00005
is: CHEBI:57783
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_2625eb64_c5e2_448d_ae3a_b807e13b9fa0
constant: false
is encoded by: hsa:2109
type: Species
has part: P38117
initial amount: NaN
initial concentration: NaN
name: ETFA:ETFB
is: SBO:0000297
boundary condition: true
has only substance units: false

metaR CHOLPtg
reactant: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ
name: choline phosphate intracellular transport
kinetic law: MODEL1310110056#
fast: false
product: MODEL1310110056#
type: Reaction

metaR r0553
is: SBO:0000176
product: MODEL1310110056#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000000
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
reversible: true

metaM fadh2 m
is: C01352
is: SBO:0000247
is: HMDB01197
is: CHEBI:58307
type: Species
name: Flavin adenine dinucleotide reduced
initial amount: NaN
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0

metaR PROSTGH2t
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110056#
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110056#
name: Prostaglandin H2 transport

metaR FAOXC260240x
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c26:0 -> c24:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 -> into pmtcoa NJ
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110056#
reactant: MODEL1310110056#
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
is described by: ECO:0000000

metaM ksii core2 deg8 l
notes: FORMULA: C36H60N3O25X CHARGE: 0
is: CHEBI:12936
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 8
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00143
has only substance units: false
type: Species
boundary condition: false

metaR G6PDA
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
reversible: false
fast: false
name: glucosamine-6-phosphate deaminase
reactant: MODEL1310110056#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.99.6
is: SBO:0000176
notes: GENE_ASSOCIATION: (132789.1) or (10007.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.99.6 Confidence Level: 4 AUTHORS: PMID:9714720 NOTES:Previously EC 5.3.1.10

metaR AICART
reversible: true
product: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
reactant: MODEL1310110056#
modifier: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.3
is: SBO:0000176
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
is described by: ECO:0000269

metaR r1929
name: Y+LAT2 Utilized transport
fast: false
reversible: false
reactant: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
is: SBO:0000185
modifier: MODEL1310110056#
is described by: ECO:0000000
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR ATPtm
modifier: MODEL1310110056#
product: MODEL1310110056#
name: ADP/ATP transporter, mitochondrial
kinetic law: MODEL1310110056#
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reactant: MODEL1310110056#
is described by: ECO:0000269
is: SBO:0000185

metaM retinal 11 cis c
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
type: Species
is: CHEBI:16066
is: HMDB02152
initial concentration: 1.0
initial amount: NaN
constant: false
name: 11-cis-retinal

metaR STCOAtx
fast: false
is described by: ECO:0000000
product: MODEL1310110056#
name: fatty acid intracellular transport
reversible: true
reactant: MODEL1310110056#
is: SBO:0000185
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_d5d3d630_ad4c_461b_ae8b_8800845cfef4
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6582
constant: false
boundary condition: true
name: SLC22A2
type: Species
is: SBO:0000252

metaR EX ksii core4 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 4-linked) exchange
type: Reaction

metaR r0552
fast: false
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.3.5.1
is described by: ECO:0000000
product: MODEL1310110056#
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_4d88aeb1_dff0_4744_bddb_a5440a2c0ab8
is: SBO:0000252
is encoded by: hsa:8803
name: SUCLA2
initial concentration: NaN
type: Species
boundary condition: true
is: E5KS60
initial amount: NaN
has only substance units: false
constant: false

metaR SCP21cx
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of phytanoylcoa from cytosol to peroxisomes.
type: Reaction

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaR ARABR
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.21
fast: false
modifier: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.2
name: arabinose reductase
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#

metaM met L e
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16643
constant: false
type: Species
name: L-methionine
has only substance units: false
is: HMDB00696

metaR DESAT18 4
type: Reaction
modifier: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.19.1
fast: false
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reactant: MODEL1310110056#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110056#

metaR RE1521M
fast: false
reversible: true
modifier: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1521
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
product: MODEL1310110056#
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176

metaR S3TASE3ly
reactant: MODEL1310110056#
name: N-acetylglucosamine-3-sulfatase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
reversible: true
fast: false
is: SBO:0000176
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_ed026fbe_ea0d_46fb_ae08_d3107d1bf49d
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:C7orf24
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: _C7orf24_1_m

metaR DNDPt29m
reversible: false
modifier: MODEL1310110056#
product: MODEL1310110056#
fast: false
name: dCDP transport via dADP antiport
reactant: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110056#
type: Reaction
is described by: ECO:0000269

metaR ATPtn
is: SBO:0000185
product: MODEL1310110056#
name: ATP diffusion in nucleus
kinetic law: MODEL1310110056#
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_3fe8f651_b4e0_4555_bbed_ee68f3aa5188
type: Species
name: GPX3
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P22352
has only substance units: false
constant: false
is encoded by: hsa:2878

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaM CE5853 e
has only substance units: false
is: CHEBI:57923
constant: false
boundary condition: false
name: alpha-CEHC-glucuronide
is: SBO:0000247
notes: FORMULA: C22H29O10 CHARGE: -1 INCHI: InChI=1/C22H30O10/c1-9-10(2)18-12(11(3)14(9)24)5-7-22(4,32-18)8-6-13(23)30-21-17(27)15(25)16(26)19(31-21)20(28)29/h15-17,19,21,24-27H,5-8H2,1-4H3,(H,28,29)/p-1/t15-,16+,17-,19-,21+,22?/m1/s1 EHMN_ABBREVIATION: CE5853
type: Species
initial amount: NaN
initial concentration: 1.0

metaR ALASm
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.29
is version of: http://identifiers.org/ec-code/2.3.1.37
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
reversible: false
type: Reaction
name: 5-aminolevulinate synthase
is: SBO:0000176

metaM succ x
is: C00042
is: CHEBI:30031
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: HMDB00254
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
name: Succinate
has only substance units: false

metaM adpac x
constant: false
type: Species
is: HMDB00448
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H8O4 CHARGE: -2
name: adipic acid
boundary condition: false
is: SBO:0000247

metaR C226CRNt
is described by: ECO:0000000
kinetic law: MODEL1310110056#
fast: false
is: SBO:0000185
reactant: MODEL1310110056#
type: Reaction
name: C226 transport into the mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
product: MODEL1310110056#
reversible: false

metaR C204CRNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
reactant: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110056#
name: arachidonic acid transport into the mitochondria
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_926cbee3_04b2_4494_82c3_9a462d758cfe
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
is: P04843
boundary condition: true
name: RPN1
is encoded by: hsa:6184
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_ae89a2d1_e41c_4056_8419_4df4a387e3c9
name: AKR7A2
boundary condition: true
is: SBO:0000252
is: O43488
is encoded by: hsa:8574
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_1a4f3436_f048_4c92_844b_f837de099329
initial amount: NaN
constant: false
is: O14732
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
name: IMPA2
is encoded by: hsa:3613

http://identifiers.org/biomodels.db/MODEL1310110056#_8c90e67b_13ca_4e29_9be4_d3406c4c31b7
constant: false
name: ST20
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q9HBF5
is encoded by: hsa:400410
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_999c0fce_9890_4dd4_905c_773318859e3d
has only substance units: false
type: Species
is encoded by: hsa:8310
initial amount: NaN
boundary condition: true
name: ACOX3
is: SBO:0000252
is: O15254
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_47b81b97_e8e0_43b3_aba5_7b5725432616
is: O75610
is encoded by: hsa:10637
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
name: LEFTY1
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_e8405cb9_0851_469f_ab1d_71544c51d772
is encoded by: hsa:79053
constant: false
is: A6NDW6
is: SBO:0000252
initial concentration: NaN
name: ALG8
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN

metaM met L c
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
name: L-methionine
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16643
is: HMDB00696
boundary condition: false
has only substance units: false

metaR DESAT18 6
product: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
modifier: MODEL1310110056#
fast: false
is: SBO:0000176
is described by: ECO:0000269
name: fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
reversible: false
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_0f8b1781_9fa1_4072_8036_b3acc676666c
constant: false
is: SBO:0000252
is: E7EML0
initial amount: NaN
has only substance units: false
is encoded by: hsa:9498
type: Species
initial concentration: NaN
name: SLC4A8
boundary condition: true

metaR GLCAASE1ly
is described by: ECO:0000000
name: beta-glucuronidase, lysosomal
is: SBO:0000176
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
reversible: false
fast: false
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction

metaM HC01609 e
name: UroporphyrinogenI
initial concentration: 1.0
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:28766
has only substance units: false

metaR r1823
name: Y+LAT2 Utilized transport
reversible: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110056#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_f3125e38_a2c4_4bf0_a13f_bdf3f466dc23
initial amount: NaN
name: SLC2A7
has only substance units: false
is: Q6PXP3
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:155184
type: Species
constant: false

metaM tcynt c
type: Species
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:18022
has only substance units: false
is: HMDB01453
initial concentration: 1.0
is: SBO:0000247
name: thiocyanate

http://identifiers.org/biomodels.db/MODEL1310110056#_645de52b_fa8e_4de4_aefb_3859dc2b82fa
type: Species
is: Q02218
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
name: OGDH
is encoded by: hsa:4967
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_291f2625_6e21_4ba7_b708_7d35cc2d1c7c
type: Species
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:80025
initial concentration: NaN
is: Q6P1K9
name: PANK2
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_b6b2049b_fbf2_4d5c_bf45_0aa1988bd200
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:226
is: P04075
initial amount: NaN
constant: false
name: ALDOA

metaR FAOXC16C14m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C14)m
type: Reaction

metaR GPIAT
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
reversible: false
fast: false
product: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
name: glucosaminylphosphatidyl inositol acetyltransferase
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110056#

metaR GALASE18ly
reversible: false
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110056#
is: SBO:0000176

metaR MTHFR3
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.5.1.20
name: 5,10-methylenetetrahydrofolatereductase (NADPH)
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (4524.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 2 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 350. NOTES:absorbed folate undergoes conversion to 5-methyl-THF within the enterocytes.
is described by: ECO:0000134
fast: false
type: Reaction
product: MODEL1310110056#

metaM lpchol hs c
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
name: lysophosphatidylcholine
type: Species
has only substance units: false
is: CHEBI:60479
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0

metaM xol7aone m
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
name: 7alpha-hydroxycholest-4-en-3-one
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
type: Species
initial concentration: 1.0
constant: false
is: HMDB01993
is: CHEBI:17899

metaR r0661
reactant: MODEL1310110056#
fast: false
product: MODEL1310110056#
is described by: ECO:0000000
reversible: false
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
kinetic law: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:

metaM HC01403 x
is: CHEBI:28325
constant: false
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: (S)-Hydroxydecanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110056#_98c988aa_f9a6_4538_a315_6699e0b9d420
is: SBO:0000252
is encoded by: hsa:56901
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q9NRX3
name: NDUFA4L2
initial concentration: NaN
constant: false
type: Species

metaR 2HBt2
is: SBO:0000185
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
name: 2-hydroxybutyrate cotransport with proton
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
modifier: MODEL1310110056#
is described by: ECO:0000269

metaR r1610
is described by: ECO:0000000
product: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR GAMt1r
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
product: MODEL1310110056#
reactant: MODEL1310110056#
name: glucosamine transport (uniport)
modifier: MODEL1310110056#
reversible: true
fast: false

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaM nadph r
constant: false
has only substance units: false
is: C00005
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: HMDB00221
boundary condition: false
type: Species
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: CHEBI:57783
is: SBO:0000247
initial concentration: 1.0

metaM 5fthf m
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
name: 5-formyltetrahydrofolate(2-)
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
is: SBO:0000247
type: Species
is: CHEBI:57457
boundary condition: false
is: HMDB01562

metaR PAN4PPe
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000134
fast: false
reactant: MODEL1310110056#
is: SBO:0000176
product: MODEL1310110056#
reversible: false
name: PAN4PPe
kinetic law: MODEL1310110056#

metaR r0660
fast: false
product: MODEL1310110056#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.2
kinetic law: MODEL1310110056#
is described by: ECO:0000000
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_c7c27cdb_94ab_4404_9783_89e8322ee41f
is: P35218
is: SBO:0000252
is encoded by: hsa:763
type: Species
initial amount: NaN
name: CA5A
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN

metaR NTD11
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
is described by: ECO:0000269
reactant: MODEL1310110056#
fast: false
is: SBO:0000176
name: 5'-nucleotidase (IMP)
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Purine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reversible: false
product: MODEL1310110056#
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#

metaR PROSTGD2t
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reactant: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000269
reversible: true
type: Reaction
kinetic law: MODEL1310110056#
name: prostaglandin transport via bicarbonate countertransport

metaR HEXCt
reversible: true
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
name: fatty acid transport via diffusion
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110056#
is described by: ECO:0000000
fast: false

metaM fadh2 c
is: HMDB01197
is: CHEBI:58307
constant: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
boundary condition: false
type: Species
name: FADH2(2-)
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM apoC Lys btn c
is: HMDB00182
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:32551
is: SBO:0000247
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
notes: FORMULA: C16H27N4O3SX CHARGE: 0
has only substance units: false
boundary condition: false

metaM xoldiolone r
type: Species
initial concentration: 1.0
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
constant: false
is: HMDB02197
has only substance units: false
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
initial amount: NaN
is: SBO:0000247
is: CHEBI:28477
boundary condition: false

metaM tymsf e
has only substance units: false
constant: false
name: Tyramine O-sulfate
boundary condition: false
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
type: Species
initial concentration: 1.0
is: HMDB06409
is: SBO:0000247
initial amount: NaN

metaR r1611
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
is: SBO:0000185
reactant: MODEL1310110056#
is described by: ECO:0000000

metaR FAOXC225C204m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaM lpchol hs e
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
initial amount: NaN
name: lysophosphatidylcholine
type: Species
is: CHEBI:60479
has only substance units: false

metaM ksii core4 pre9 g
initial concentration: 1.0
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 9
boundary condition: false
constant: false
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
is: SBO:0000247
initial amount: NaN
is: CHEBI:28067
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_74d8e489_c110_4d17_9ef3_28795275f338
initial amount: NaN
constant: false
boundary condition: true
is: B7Z6M3
name: DGKZ
has only substance units: false
is encoded by: hsa:8525
type: Species
is: SBO:0000252
initial concentration: NaN

metaR AGDC
product: MODEL1310110056#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.25
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000176
reversible: false
name: N-acetylglucosamine-6-phosphate deacetylase
reactant: MODEL1310110056#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (51005.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.1.25 Confidence Level: 2 AUTHORS: NOTES:acetylglucosamine phosphate deacetylase; acetylaminodeoxyglucosephosphate acetylhydrolase; 2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase

metaM tchola c
is: HMDB00036
type: Species
has only substance units: false
is: CHEBI:36257
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
initial concentration: 1.0
name: taurocholic acid
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaM xol7a r
initial concentration: 1.0
name: 20-hydroxycholesterol
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:1296
has only substance units: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
constant: false
is: HMDB01496

http://identifiers.org/biomodels.db/MODEL1310110056#_0aa7bc01_efb2_456b_9f2a_6e38e7a69eeb
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2348
type: Species
is: SBO:0000252
name: FOLR1

metaR ITCOAL1m
modifier: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
reversible: true
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
is: SBO:0000176
kinetic law: MODEL1310110056#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.4
reactant: MODEL1310110056#

metaR r1612
modifier: MODEL1310110056#
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR CORE2GTg
is described by: ECO:0000000
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
modifier: MODEL1310110056#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.102
fast: false

metaR L LACDcm
modifier: MODEL1310110056#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (124637.1) SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:18831974 NOTES:NCD/TDV. This reaction exists in yeast, but no evidence could be found this exists in humans. However, there may be intramitochondrial lactate dehydrogenase and lactate transport into mitochondria
reversible: false
name: L-Lactate dehydrogenase, cytosolic/mitochondrial
is: SBO:0000185
kinetic law: MODEL1310110056#

metaR G14T5g
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110056#
is: SBO:0000176
modifier: MODEL1310110056#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000

metaR UGALNACtg
kinetic law: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110056#
name: UDP-GalNAc Golgi transport via CMP antiport
is: SBO:0000185
reactant: MODEL1310110056#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_5ddc85d7_8997_43df_8229_4fab67e62bbe
is encoded by: hsa:376497
name: SLC27A1
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: Q6PCB7
constant: false
initial concentration: NaN
is: SBO:0000252

metaR r1613
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110056#
reactant: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000000
kinetic law: MODEL1310110056#
type: Reaction

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaR XYLTt
is: SBO:0000185
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110056#
name: Xylitol transport via passive diffusion
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
reactant: MODEL1310110056#

metaR RE3002X
reversible: true
fast: false
kinetic law: MODEL1310110056#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/5.3.3.8
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
reactant: MODEL1310110056#
name: RE3002
is described by: ECO:0000000

metaM hs deg23 l
boundary condition: false
constant: false
notes: FORMULA: C31H49NO29S CHARGE: -2
is: HMDB02704
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: CHEBI:21338

metaR ACETONEt2m
reactant: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
name: acetone mitochondrial transport via proton symport
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110056#
fast: false
modifier: MODEL1310110056#

metaM m4masn g
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
is: C05881
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C46H77N2O35X CHARGE: 0
has only substance units: false

metaM xol7aone r
constant: false
boundary condition: false
has only substance units: false
name: 7alpha-hydroxycholest-4-en-3-one
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: CHEBI:17899
is: HMDB01993
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR r1614
product: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110056#
type: Reaction
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM nadph m
type: Species
initial concentration: 1.0
is: HMDB00221
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: CHEBI:57783
constant: false
is: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM arg L m
is: HMDB00517
is: CHEBI:32682
name: L-argininium(1+)
constant: false
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: SBO:0000247
initial amount: NaN

metaM prostgi2 r
initial concentration: 1.0
name: prostaglandin I2(1-)
boundary condition: false
is: CHEBI:57403
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB01335
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
type: Species
has only substance units: false

metaM ksii core2 pre6 g
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 6
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C61H98N5O46SX CHARGE: -2
initial concentration: 1.0
is: CHEBI:28067

http://identifiers.org/biomodels.db/MODEL1310110056#_b31acc78_c436_4fc3_b374_8a6fd632e37b
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:AF080579
initial amount: NaN
is: SBO:0000252
name: _AF080579_1_c
initial concentration: NaN
type: Species

metaM tchola e
is: HMDB00036
notes: FORMULA: C26H45NO7S CHARGE: 0
has only substance units: false
name: taurocholic acid
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
boundary condition: false

metaM ile L m
has only substance units: false
boundary condition: false
initial amount: NaN
name: L-isoleucine
is: CHEBI:17191
initial concentration: 1.0
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
is: HMDB00172
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_4c5c0b92_a2b9_4088_8e82_ed5d6b977f52
type: Species
boundary condition: true
name: DBT
initial amount: NaN
has only substance units: false
constant: false
is: P11182
initial concentration: NaN
is encoded by: hsa:1629
is: SBO:0000252

metaR C51CPT1
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tiglylcarnitine
type: Reaction

metaR PROSTGE2t2
modifier: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110056#
name: prostaglandin uniport
type: Reaction
product: MODEL1310110056#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110056#
fast: false

metaM alaala c
has only substance units: false
constant: false
is: HMDB00725
initial amount: NaN
notes: FORMULA: C6H12N2O3 CHARGE: 0
boundary condition: false
type: Species
initial concentration: 1.0
name: D-Alanyl-D-alanine
is: SBO:0000247

metaM 6pgl r
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
boundary condition: false
constant: false
is: HMDB01127
is: CHEBI:57955
initial amount: NaN
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_ed3cbb26_e884_4427_a6b1_471352cdd61e
boundary condition: true
type: Species
initial amount: NaN
constant: false
name: NDUFB7
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4713
is: P17568
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_d6376615_828f_4cc5_9670_5230c6d10f59
initial amount: NaN
is encoded by: hsa:10157
initial concentration: NaN
is: SBO:0000252
name: AASS
constant: false
type: Species
has only substance units: false
boundary condition: true
is: A4D0W4

metaR r1615
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110056#
is: SBO:0000185
reactant: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#

metaR r0559
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
product: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000000
reactant: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:

metaR EX 3tetd7ecoacrn
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy tetradecenoyl-7-carnitine
type: Reaction

metaR FTCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.5
is described by: ECO:0000134
name: formimidoyltransferase cyclodeaminase
modifier: MODEL1310110056#
type: Reaction
reversible: false
reactant: MODEL1310110056#
product: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110056#_2b4e289d_b387_419e_9183_07eb91e61192
has only substance units: false
has part: B4DP47
has part: P21953
constant: false
initial amount: NaN
has part: P11182
initial concentration: NaN
boundary condition: true
is encoded by: hsa:594
type: Species
is encoded by: hsa:593
is encoded by: hsa:1629
name: DBT:DLD:BCKDHA:BCKDHB
is: SBO:0000297

metaR EX ivcrn
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for isovaleryl carnitine
type: Reaction

metaR MMEm
is version of: http://identifiers.org/ec-code/5.1.99.1
modifier: MODEL1310110056#
type: Reaction
name: methylmalonyl-CoA epimerase/racemase
is described by: ECO:0000269
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
reversible: true
reactant: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000176
fast: false

metaR r1616
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#
is described by: ECO:0000000
modifier: MODEL1310110056#

metaR FAOXC204C184m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

metaM ksi pre31 g
is: HMDB00175
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: C00130
has only substance units: false
is: CHEBI:58053
constant: false
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
name: keratan sulfate I biosynthesis, precursor 31

metaM o2s c
initial concentration: 1.0
constant: false
type: Species
is: HMDB02168
initial amount: NaN
name: superoxide
has only substance units: false
is: SBO:0000247
is: CHEBI:18421
boundary condition: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704

metaM 2obut c
is: CHEBI:16763
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
constant: false
name: 2-Oxobutanoate
is: HMDB00005
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: C00109
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_5dfb8162_e3a0_4230_9926_8c81518fb926
is: SBO:0000252
has only substance units: false
name: _AI915649_1_c
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:AI915649
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_4116f6f1_5784_4345_9423_acdce2a255a6
is encoded by: hsa:8501
initial concentration: NaN
is: O75387
boundary condition: true
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
name: SLC43A1
has only substance units: false

metaR r0558
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reactant: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
kinetic law: MODEL1310110056#
type: Reaction
product: MODEL1310110056#

metaM HC01399 m
is: CHEBI:27466
has only substance units: false
type: Species
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
name: (S)-3-Hydroxytetradecanoyl-CoA
boundary condition: false

metaR MI13PP
is described by: ECO:0000000
kinetic law: MODEL1310110056#
fast: false
type: Reaction
name: inositol-1,3-bisphosphate 3-phosphatase
product: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
is: SBO:0000176
reversible: false

metaR FAOXC240200x
type: Reaction
name: Beta oxidation of long chain fatty acid
reversible: false
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:0 -> c20:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
kinetic law: MODEL1310110056#
product: MODEL1310110056#
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

metaM alaala e
name: D-Alanyl-D-alanine
constant: false
is: HMDB00725
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C6H12N2O3 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0

metaR r2497
type: Reaction
product: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
reactant: MODEL1310110056#
fast: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

http://identifiers.org/biomodels.db/MODEL1310110056#_b8ecc413_f687_4bbc_91ab_0470781e6c4e
constant: false
initial amount: NaN
type: Species
boundary condition: true
is: Q14032
is encoded by: hsa:570
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: BAAT

metaR r1617
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000
modifier: MODEL1310110056#
type: Reaction
fast: false

metaR LSTO2r
is version of: http://identifiers.org/ec-code/1.14.21.6
kinetic law: MODEL1310110056#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110056#
fast: false
name: Lathosterol oxidase
reactant: MODEL1310110056#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
modifier: MODEL1310110056#

metaR C101CPT1
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decenoylcarnitine
type: Reaction

metaR BTNt2
reversible: true
reactant: MODEL1310110056#
type: Reaction
fast: false
is described by: ECO:0000269
product: MODEL1310110056#
name: Biotin reversible transport via proton symport
is: SBO:0000185
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD

metaM ocdececrn c
name: 11-octadecenoyl carnitine
type: Species
has only substance units: false
is: HMDB06351
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C25H47NO4 CHARGE: 0
is: SBO:0000247
initial amount: NaN
constant: false

metaM maltpt e
has only substance units: false
is: C02052
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5141
initial amount: NaN
is: HMDB01296
boundary condition: false
initial concentration: 1.0
constant: false
name: maltopentaose
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_a9765ea5_8b3d_49e9_893b_94bc85e5500e
initial amount: NaN
type: Species
name: ITPA
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q9BY32
is encoded by: hsa:3704
constant: false

metaM maltttr e
is: C02052
is: SBO:0000247
boundary condition: false
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
initial amount: NaN
is: HMDB01296
name: Maltotetraose
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/5141
type: Species
initial concentration: 1.0

metaM CE5121 m
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:57449
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
constant: false
boundary condition: false
name: trans-3-decenoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110056#_61d1f501_1fff_4df7_b161_c53637ee74f6
boundary condition: true
initial concentration: NaN
name: FDFT1
is: SBO:0000252
is: P37268
initial amount: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:2222

http://identifiers.org/biomodels.db/MODEL1310110056#_979eaed1_66db_45ba_805b_ed99d142e160
is: A5JJ20
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
name: SLC4A4
is encoded by: hsa:8671

metaR r1607
kinetic law: MODEL1310110056#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110056#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110056#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_18f63946_79d4_4418_9755_94b73f023ac5
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6515
constant: false
boundary condition: true
type: Species
name: SLC2A3
is: P11169
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_8b73ed3e_4703_428a_9aba_8e0d314e03be
is encoded by: hsa:953
boundary condition: true
name: ENTPD1
is: Q86VV3
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN

metaM ddece1crn c
has only substance units: false
is: HMDB03712
type: Species
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C19H35NO4 CHARGE: 0
initial concentration: 1.0
name: dodecenoyl carnitine
is: SBO:0000247

metaM zym int2 r
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
initial concentration: 1.0
has only substance units: false
is: CHEBI:52386
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
name: zymosterol intermediate 2

http://identifiers.org/biomodels.db/MODEL1310110056#_a7b314a7_3188_4d82_add0_4a9a0003f222
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:3038
initial amount: NaN
name: HAS3
is: O00219
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_76f748e9_28e5_4c42_8082_1b910a3f7a83
has only substance units: false
boundary condition: true
is: P30084
name: ECHS1
is encoded by: hsa:1892
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_33ada50f_2530_47cb_82d7_fc1e41bfeb24
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is: P40394
boundary condition: true
has only substance units: false
is encoded by: hsa:131
name: ADH7

metaR DHORD9
reversible: false
reactant: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000185
name: dihydoorotic acid dehydrogenase (quinone10)
type: Reaction
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.3.5.2
modifier: MODEL1310110056#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )

metaR r1606
is: SBO:0000185
reactant: MODEL1310110056#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true

metaR 34DHXMANDACOX NADP
reversible: true
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
type: Reaction
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
product: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000269

metaR FMNAT
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
reactant: MODEL1310110056#
name: FMN adenylyltransferase
is: SBO:0000176
is described by: ECO:0000134
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.7.2
product: MODEL1310110056#

metaM o2s e
is: CHEBI:18421
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: HMDB02168
initial amount: NaN
has only substance units: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
name: superoxide

metaR O2St
reactant: MODEL1310110056#
fast: false
product: MODEL1310110056#
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
name: superoxide anion transport via diffusion (extracellular)
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110056#_e88046b4_9a6b_4270_81ee_1513e01d638a
is: Q9NRZ5
is encoded by: hsa:56895
type: Species
initial amount: NaN
boundary condition: true
constant: false
name: AGPAT4
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM pacald c
name: phenylacetaldehyde
is: HMDB06236
initial amount: NaN
constant: false
is: CHEBI:16424
boundary condition: false
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR r0443
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
modifier: MODEL1310110056#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
product: MODEL1310110056#
reversible: false
kinetic law: MODEL1310110056#
is: SBO:0000176
reactant: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42

http://identifiers.org/biomodels.db/MODEL1310110056#_775d9ae5_3295_4cb3_98d6_fef3211d8ad6
initial amount: NaN
name: NDUFA4
is encoded by: hsa:4697
boundary condition: true
has only substance units: false
is: O00483
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species

metaM inost c
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00211
initial amount: NaN
is: CHEBI:17268
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
type: Species
constant: false
name: myo-inositol

metaR r1609
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
product: MODEL1310110056#

metaR r1932
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110056#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110056#_e1a635e4_bfa6_4221_9a08_a6ef72f5ce17
boundary condition: true
is encoded by: hsa:1103
type: Species
initial concentration: NaN
is: D3DX95
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
name: CHAT

metaR FAOXC225C204x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_78f60063_3c92_4a1a_b3dd_5f6d84ab9389
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
name: ENTPD3
is: O75355
is encoded by: hsa:956
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_b5f25486_19d9_4b8d_a1ee_3570e08b3e9d
boundary condition: true
constant: false
type: Species
name: GLS2
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:27165
initial amount: NaN

metaR r1608
product: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110056#
fast: false
is: SBO:0000185
reactant: MODEL1310110056#

metaR r1931
kinetic law: MODEL1310110056#
is described by: ECO:0000000
product: MODEL1310110056#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110056#
reactant: MODEL1310110056#
reversible: false
fast: false
type: Reaction
is: SBO:0000185

metaM CE0713 m
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB02329
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:30623
name: 3-oxolinoleoyl-CoA

metaR r2347
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: Organic anion transporter 5 Utilized transport
type: Reaction
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_dc962677_68cf_4a57_8334_78ccc143f21d
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4731
constant: false
initial amount: NaN
name: NDUFV3
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_b862c8c1_2222_4a35_a22b_4ebd5aeef127
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is: P14854
constant: false
boundary condition: true
is encoded by: hsa:1340
initial concentration: NaN
name: COX6B1

http://identifiers.org/biomodels.db/MODEL1310110056#_980193ef_ef96_436f_a458_d6deaec1e48c
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: ENPP1
initial amount: NaN
is encoded by: hsa:5167
type: Species
constant: false
is: P22413

metaR S6T7g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
reversible: false
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110056#
is described by: ECO:0000000
fast: false
product: MODEL1310110056#
modifier: MODEL1310110056#
is: SBO:0000176

metaR FK
type: Reaction
kinetic law: MODEL1310110056#
is described by: ECO:0000000
name: Fucokinase
is version of: http://identifiers.org/ec-code/2.7.1.52
fast: false
reversible: false
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
reactant: MODEL1310110056#
is: SBO:0000176
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_a4a0e548_1925_496c_a1dd_0e769548d49f
type: Species
initial amount: NaN
is: Q56NI9
name: ESCO2
is encoded by: hsa:157570
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false

metaM 2dodtricoa m
is: HMDB11123
constant: false
is: C05279
boundary condition: false
name: 2,6,9-dodecatrienoylcoa
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
initial concentration: 1.0

metaR r2346
kinetic law: MODEL1310110056#
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110056#
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaM arg L c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:32682
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
type: Species
name: L-argininium(1+)
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: HMDB00517

metaR DHFR
product: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
kinetic law: MODEL1310110056#
is described by: ECO:0000254
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: true
modifier: MODEL1310110056#
name: dihydrofolate reductase

metaR G14T6g
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
modifier: MODEL1310110056#
fast: false
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110056#_725211b8_f09b_48be_b1c4_338a7a6d4a1c
constant: false
has part: P07195
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: LDHA:LDHB
type: Species
is encoded by: hsa:3945
is: SBO:0000297
is encoded by: hsa:3939
has part: P00338
boundary condition: true

metaR CYSTS
is described by: ECO:0000269
modifier: MODEL1310110056#
name: cystathionine beta-synthase
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.22
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (875.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.2.1.22 Confidence Level: 4 AUTHORS: PMID:681363,PMID:9790750 NOTES:NCD
fast: false
product: MODEL1310110056#
reversible: false
kinetic law: MODEL1310110056#

metaM ksi deg23 l
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:12936
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00143
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
name: keratan sulfate I, degradation product 23
constant: false
has only substance units: false

metaR CYTDt
type: Reaction
modifier: MODEL1310110056#
is: SBO:0000185
reversible: true
name: cytidine facilated transport in cytosol
fast: false
reactant: MODEL1310110056#
is described by: ECO:0000269
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
product: MODEL1310110056#

metaR UGLT
name: UDPglucose--hexose-1-phosphate uridylyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.12
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110056#
fast: false
reversible: true
type: Reaction
product: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_f2b57ad3_7302_452f_b39f_0d60ff7e6811
constant: false
has only substance units: false
type: Species
name: GCK
is encoded by: hsa:2645
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_873e2bf9_7d35_4f94_9a04_fe325a03c905
boundary condition: true
is encoded by: hsa:1327
has only substance units: false
constant: false
initial amount: NaN
name: COX4I1
initial concentration: NaN
type: Species
is: SBO:0000252
is: P13073

metaM 3octpencoa m
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5280355
name: 3,6,9,12,15-octadecapentenoylcoa
constant: false
initial concentration: 1.0
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
type: Species
boundary condition: false
has only substance units: false

metaM clpndcoa x
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
is: C16166
is: HMDB06267
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
name: clupanodonyl CoA
type: Species
is: http://identifiers.org/pubchem.compound/47205476
has only substance units: false

metaR DOLPMT U
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.83
fast: false
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
type: Reaction
name: Dolichyl-phosphate D-mannosyltransferase (uterus)
is: SBO:0000176
modifier: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: false

metaR HSPGtly
product: MODEL1310110056#
type: Reaction
reversible: false
fast: false
is: SBO:0000185
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: heparan sulfate transport, extracellular to lysosome

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaR r0339
is version of: http://identifiers.org/ec-code/3.1.2.2
is version of: http://identifiers.org/ec-code/2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.2.22
product: MODEL1310110056#
is described by: ECO:0000000
reactant: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
modifier: MODEL1310110056#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
type: Reaction
fast: false
kinetic law: MODEL1310110056#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110056#_ee92a82e_58da_4108_99ed_71f6725cafc5
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:5831
name: PYCR1
has only substance units: false
is: A6NFM2

metaR DOCO13ECOAtxc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 13-docosenoylcoa into peroxisomes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_fa2b7bb7_7c40_4c6e_9ef7_5741bab291ab
is: SBO:0000252
is encoded by: hsa:1593
boundary condition: true
constant: false
type: Species
name: CYP27A1
is: Q02318
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR DHDPBMTm
modifier: MODEL1310110056#
is: SBO:0000176
name: dihydroxydecaprenylbenzoate methyltransferase
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.1.114
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: 2.1.1.114 Confidence Level: 4 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.1.1.114 IT
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reversible: false
type: Reaction

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

metaM arg L e
is: CHEBI:32682
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00517
has only substance units: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
name: L-argininium(1+)
initial amount: NaN

metaR r2344
is described by: ECO:0000000
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
reversible: true
kinetic law: MODEL1310110056#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_86647f42_5d1d_4e18_b6b5_47451b3021e0
constant: false
initial amount: NaN
initial concentration: NaN
name: ALDH3A1
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P30838
is encoded by: hsa:218

metaM hcys L c
name: L-homocysteine
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
is: HMDB00742
is: CHEBI:17588
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
constant: false

metaR NDP7ex
is version of: http://identifiers.org/ec-code/3.6.1.6
is: SBO:0000176
type: Reaction
product: MODEL1310110056#
reversible: false
kinetic law: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
name: nucleoside-diphosphatase (UDP), extracellular
reactant: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000269

metaM nadph c
is: HMDB00221
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
type: Species
boundary condition: false
is: CHEBI:57783

http://identifiers.org/biomodels.db/MODEL1310110056#_f20fd557_f1c4_44b7_abef_0039995f8c17
type: Species
has only substance units: false
name: _AI990637_1_x
is: SBO:0000252
is encoded by: hsa:AI990637
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_ff18a3d9_1dbc_497b_aa04_fcfa53dd0c41
is encoded by: hsa:1376
name: CPT2
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: P23786

metaR RE2986X
name: RE2986
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:10970790,PMID:7775433 NOTES:
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
fast: false
type: Reaction

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaR LACLt
is described by: ECO:0000134
kinetic law: MODEL1310110056#
reversible: false
name: Lactate transport
product: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMCID: PMC1820816. NOTES:for regeneration of nad in peroxisomes, for providing nad to the beta oxidation
is: SBO:0000185
reactant: MODEL1310110056#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_41917427_f6d3_4bb2_9f7a_44033805c7ac
constant: false
is: SBO:0000252
is encoded by: hsa:4709
name: NDUFB3
initial concentration: NaN
is: Q6IB80
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN

metaM ksii core2 pre10 g
name: keratan sulfate II biosynthesis, precursor 10
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:28067
boundary condition: false
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
initial concentration: 1.0
type: Species
constant: false

metaR AG13T4g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110056#
reversible: false
modifier: MODEL1310110056#

metaM dsT antigen g
is: HMDB01440
name: disialyl-T antigen
notes: FORMULA: C36H56N3O26X CHARGE: -2
constant: false
is: CHEBI:16497
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaR AMETtd
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
name: diffusion of S-Adenosyl-L-methionine
fast: false
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110056#_45699139_5a65_4046_baab_25432144da09
constant: false
is: E9KL44
is encoded by: hsa:3030
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: HADHA
initial concentration: NaN

metaM tetdec2crn c
is: HMDB02014
name: tetradecadienoyl carnitine
is: SBO:0000247
notes: FORMULA: C21H37NO4 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
boundary condition: false

metaM 3ttetddcoa c
has only substance units: false
is: SBO:0000247
is: HMDB02014
constant: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
boundary condition: false
name: 3-hydroxy trans5,8tetradecadienoyl coa
initial amount: NaN
initial concentration: 1.0
type: Species

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_63f78d50_36e3_4f93_aa65_b4695f056c47
is: P00918
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
name: CA2
is encoded by: hsa:760
initial concentration: NaN
is: SBO:0000252

metaM ksi pre5 g
name: keratan sulfate I biosynthesis, precursor 5
boundary condition: false
initial amount: NaN
is: CHEBI:28067
type: Species
is: SBO:0000247
notes: FORMULA: C101H164N7O75SX CHARGE: -2
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110056#_f3f8aa83_66e9_4e31_bca5_75d2d95120ae
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:9187
name: SLC24A1
is: SBO:0000252
is: B4DUG1

metaR r1109
product: MODEL1310110056#
reversible: true
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
fast: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110056#

metaM o2s m
constant: false
type: Species
name: Superoxide anion
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB02168
initial amount: NaN
boundary condition: false
is: CHEBI:18421
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: C00704

http://identifiers.org/biomodels.db/MODEL1310110056#_3f4dc5c7_c265_46d1_bbe4_57600fcfc389
boundary condition: true
name: ND4L
initial concentration: NaN
is: Q7GXZ4
is encoded by: hsa:4539
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false

metaR r2341
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110056#
reversible: true
is: SBO:0000185
product: MODEL1310110056#
name: Organic anion transporter 5 Utilized transport
type: Reaction
reactant: MODEL1310110056#

metaR MALSO4tm
is described by: ECO:0000269
name: Malate:sulfate antiport, mitochondrial
reversible: true
reactant: MODEL1310110056#
modifier: MODEL1310110056#
is: SBO:0000185
product: MODEL1310110056#
type: Reaction
fast: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110056#_790c0f29_844c_460d_9ad2_19acc9718944
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:AI971023
initial concentration: NaN
is: SBO:0000252
name: _AI971023_1_c

metaR DDECE1CRNe
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of dodecenoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_59d46a80_43b3_4893_af7c_c503f0a94f65
initial amount: NaN
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI653169
name: _AI653169_1_c
is: SBO:0000252
boundary condition: true

metaM ksi pre10 g
type: Species
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 10
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
is: CHEBI:58053
has only substance units: false
boundary condition: false
is: C00130

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

metaR PAPtg
reversible: false
reactant: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110056#
name: adenosine 3',5'-bisphosphate Golgi transport
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110056#

metaR RE3003M
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110056#
type: Reaction
name: RE3003
reversible: true
fast: false
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/5.3.3.8
is described by: ECO:0000000
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110056#
is: SBO:0000176

metaR EX arachcoa LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: arachidyl coenzyme A exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_3f8b19bc_e8f7_4c9d_8feb_3e1b0a4ba64f
is: P06858
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4023
name: LPL
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true

metaR SIAASEly
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110056#
is: SBO:0000176
modifier: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
name: sialidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false

metaM adpac c
is: SBO:0000247
is: HMDB00448
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C6H8O4 CHARGE: -2
initial amount: NaN
has only substance units: false
boundary condition: false
name: adipic acid

metaR CHOLt4
kinetic law: MODEL1310110056#
name: choline, sodium cotransport
reactant: MODEL1310110056#
is described by: ECO:0000269
is: SBO:0000185
reversible: true
modifier: MODEL1310110056#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
product: MODEL1310110056#

metaR C4tcx
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine from peroxisomes
type: Reaction

metaM tetdec2crn e
name: tetradecadienoyl carnitine
initial amount: NaN
constant: false
is: HMDB05066
notes: FORMULA: C21H37NO4 CHARGE: 0
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR TETPENT6COAtx
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000185
name: fatty acid intracellular transport
reversible: true
kinetic law: MODEL1310110056#
type: Reaction

metaR NACHEX4ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110056#
reactant: MODEL1310110056#
fast: false
type: Reaction
product: MODEL1310110056#
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110056#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110056#_17fc5640_186f_4b3d_a2cf_bcf4d5ca398c
is encoded by: hsa:3028
boundary condition: true
initial amount: NaN
is: Q99714
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
has only substance units: false
name: HSD17B10

metaR CYSASNNaEx
product: MODEL1310110056#
fast: false
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
is described by: ECO:0000269
reactant: MODEL1310110056#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_f6a5ce88_6273_4f02_b88d_1670f2afe863
initial concentration: NaN
has only substance units: false
name: SLC26A1
boundary condition: true
type: Species
is encoded by: hsa:10861
constant: false
is: SBO:0000252
initial amount: NaN

metaR BDMT U
type: Reaction
reversible: false
reactant: MODEL1310110056#
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.4.1.142
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
fast: false
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000000

metaM mi4p D c
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
name: 1D-myo-inositol 4-phosphate(2-)
is: CHEBI:58469
is: HMDB01313
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3-,4+,5-,6-/m0/s1
constant: false
initial concentration: 1.0
initial amount: NaN

metaR TSTSTERONEtr
reactant: MODEL1310110056#
reversible: true
fast: false
product: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
name: testosterone intracellular transport
type: Reaction
kinetic law: MODEL1310110056#

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaR ILEt5m
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110056#
reversible: true
product: MODEL1310110056#
fast: false
name: Isoleucine mitochondrial transport
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_722017dd_7966_416d_8ae8_0533f0969089
type: Species
boundary condition: true
initial amount: NaN
name: UCK2
is encoded by: hsa:7371
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q9BZX2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_f247e2af_e889_42fb_9d29_84a4b42fec45
has only substance units: false
is: A8K8P8
initial amount: NaN
is encoded by: hsa:2530
constant: false
boundary condition: true
type: Species
is: SBO:0000252
name: FUT8
initial concentration: NaN

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_0fb6c0ca_a157_4e9d_9b75_8303f2d2b6c0
is encoded by: hsa:5319
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P04054
initial concentration: NaN
name: PLA2G1B
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_8939d7b6_88a5_4007_ae28_988d359797f6
boundary condition: true
type: Species
is: Q9BY49
name: PECR
is encoded by: hsa:55825
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaR HMGCOARc
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.34
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
modifier: MODEL1310110056#
is described by: ECO:0000134
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
product: MODEL1310110056#

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaR ASCBOX
is: SBO:0000176
reversible: false
product: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
type: Reaction
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: ascorbic acid oxidase
is described by: ECO:0000000

metaR RETH2e
product: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110056#
reversible: false
name: retinyl ester hydrolase (11-cis), extracellular
type: Reaction
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false

metaR PI45P5P
fast: false
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
kinetic law: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.3.36
modifier: MODEL1310110056#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
product: MODEL1310110056#

metaR STRDNCCRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110056#
is: SBO:0000185
modifier: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110056#
reversible: false
name: transport into the mitochondria (carnitine)

http://identifiers.org/biomodels.db/MODEL1310110056#_169b8e1e_38a5_4bf5_be30_5f75dc46fa36
constant: false
name: SLC4A10
is: B7Z1R0
initial concentration: NaN
boundary condition: true
is encoded by: hsa:57282
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaR RE3568C
name: RE3568
is: SBO:0000176
reactant: MODEL1310110056#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#

metaM hs deg22 l
type: Species
notes: FORMULA: C37H56NO35S CHARGE: -3
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:21338
initial concentration: 1.0
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: SBO:0000247
is: HMDB02704

metaR P5CDm
is: SBO:0000176
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.5.1.12
kinetic law: MODEL1310110056#
reversible: false
product: MODEL1310110056#
modifier: MODEL1310110056#
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
fast: false
reactant: MODEL1310110056#
type: Reaction

metaR GLUt2m
name: L-glutamate reversible transport via proton symport, mitochondrial
notes: GENE_ASSOCIATION: (83733.1) or (8604.1) or (79751.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is described by: ECO:0000269
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000185
product: MODEL1310110056#
reactant: MODEL1310110056#

metaR FAOXC201C181x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_f3fbaf02_7a7a_40f2_8a1f_323e506c9b7b
constant: false
has only substance units: false
initial concentration: NaN
name: PIGA
is: SBO:0000252
is encoded by: hsa:5277
initial amount: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_0d1bc7bf_6e8a_431b_a322_4ce938e8a543
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: _AI191472_1_c
has only substance units: false
boundary condition: true
is encoded by: hsa:AI191472
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_3ace66fe_2c85_4e2c_8d84_da9adbf0fb11
is: Q1ET61
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:6818
type: Species
is: SBO:0000252
name: SULT1A3
boundary condition: true

metaR DTMPK
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000176
name: dTMP kinase
is version of: http://identifiers.org/ec-code/2.7.4.9
fast: false
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110056#
reversible: true
modifier: MODEL1310110056#
type: Reaction
is described by: ECO:0000269

metaM inost e
constant: false
is: HMDB00211
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
boundary condition: false
name: myo-inositol
type: Species
is: CHEBI:17268

metaM 1glyc hs e
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H13O7PFULLRCO2 CHARGE: -1
boundary condition: false
name: 1 acyl phosphoglycerol
constant: false
is: HMDB00224
is: SBO:0000247
is: CHEBI:58190
type: Species

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

metaM 4hexdtricoa x
initial amount: NaN
boundary condition: false
is: HMDB02288
name: 4,7,10-hexadecatrienoylcoa
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial concentration: 1.0

metaR EX 3hdececrn
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecenoyl carnitine
type: Reaction

metaR r1106
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110056#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
name: Postulated transport reaction
is described by: ECO:0000000

metaR CTPtn
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
reversible: true
fast: false
product: MODEL1310110056#
name: CTP diffusion in nucleus
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110056#_a46f1885_fda1_48e8_8c6b_6bcb20f07391
is: SBO:0000252
is: Q02318
is encoded by: hsa:1593
boundary condition: true
name: CYP27A1
has only substance units: false
initial concentration: NaN
type: Species
constant: false
initial amount: NaN

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaR AHEXASE2ly
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
type: Reaction
product: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176

metaR ORNt4m
modifier: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
reversible: true
fast: false
reactant: MODEL1310110056#
name: ornithine mitochondrial transport exchange with citruline
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000269
is: SBO:0000185

metaR KSItly
is described by: ECO:0000000
name: keratan sulfate I transport, extracellular to lysosome
product: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
reversible: false
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_1f04d261_8d1c_482e_a6d7_e31761fa346b
is: P00338
is encoded by: hsa:3939
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
constant: false
has only substance units: false
name: LDHA
initial amount: NaN

metaM thcholoylcoa x
boundary condition: false
has only substance units: false
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-8-9-30-36-31(12-15-48(29,30)6)47(5)14-11-28(56)19-27(47)20-33(36)58)7-10-32(57)26(2)45(63)79-18-17-50-35(59)13-16-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-34-39(74-76(64,65)66)38(60)44(73-34)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,26?,27+,28-,29-,30+,31+,32?,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27403
is: HMDB12456
name: 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA
constant: false
type: Species
initial amount: NaN

metaM xoldiolone c
initial concentration: 1.0
boundary condition: false
is: CHEBI:28477
type: Species
has only substance units: false
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
is: SBO:0000247
constant: false
is: HMDB02197
initial amount: NaN
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one

http://identifiers.org/biomodels.db/MODEL1310110056#_adf63c4a_2722_44c6_9b8e_1cc0e1fe0b50
constant: false
is encoded by: hsa:4953
is: P11926
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: ODC1
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_b84422b5_4223_4212_a77e_476c439e8c90
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:84890
boundary condition: true
is: B3KXN9
type: Species
is: SBO:0000252
name: ADO
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_1689c02d_3b95_45de_a401_8fe70855dff8
type: Species
is encoded by: hsa:LOC727762
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: _LOC727762_1_m

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaR RE1448N
product: MODEL1310110056#
reactant: MODEL1310110056#
reversible: true
name: RE1448
is: SBO:0000176
fast: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
is described by: ECO:0000000
type: Reaction

metaR S6TASE4ly
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110056#
name: N-acetylgalactosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110056#
reversible: true
reactant: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_04099a03_3a7c_4c08_ae70_91f7ef4c262a
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
name: ACADVL
initial concentration: NaN
has only substance units: false
is: P49748
is encoded by: hsa:37

http://identifiers.org/biomodels.db/MODEL1310110056#_65a6af83_f0e7_43b0_9c49_c61b4b9bdec1
constant: false
name: _AA081045_1_m
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:AA081045
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_45078982_c86e_4f37_b837_2f6d5ed58372
is: Q96N66
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:79143
initial concentration: NaN
is: SBO:0000252
name: MBOAT7
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_1e5c9ed9_b57b_48ed_a574_a689ebb25f5e
initial amount: NaN
type: Species
is: B2ZGL7
boundary condition: true
is: SBO:0000252
is encoded by: hsa:11343
initial concentration: NaN
has only substance units: false
constant: false
name: MGLL

http://identifiers.org/biomodels.db/MODEL1310110056#_04a07c91_dbc3_4085_93c7_cd297aed8271
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:27430
constant: false
name: MAT2B
type: Species

metaM HC01403 m
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
name: (S)-Hydroxydecanoyl-CoA
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:28325
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_8a3c420e_860d_4a59_9a4f_71fdf3ec9bf3
boundary condition: true
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
has only substance units: false
name: NDUFS5
is: Q6IBA0
is encoded by: hsa:4725
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_945df038_92dd_4991_8b44_16ffdf3bce7f
is: Q9NRR6
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:56623
name: INPP5E
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM 3uib c
is: SBO:0000247
notes: FORMULA: C5H9N2O3 CHARGE: -1 INCHI: InChI=1S/C5H10N2O3/c1-3(4(8)9)2-7-5(6)10/h3H,2H2,1H3,(H,8,9)(H3,6,7,10) HEPATONET_1.0_ABBREVIATION: HC01371 EHMN_ABBREVIATION: C05100
is: HMDB02031
name: 3-Ureidoisobutyrate
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:1670
type: Species
boundary condition: false
initial concentration: 1.0

metaM 2dodtricoa x
type: Species
is: HMDB11123
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: SBO:0000247
boundary condition: false
name: 2,6,9-dodecatrienoylcoa
is: C05279

metaM hpdca e
is: SBO:0000247
has only substance units: false
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
initial amount: NaN
is: CHEBI:32366
initial concentration: 1.0
name: margarate
constant: false
boundary condition: false
type: Species
is: HMDB02259

metaM acnam l
constant: false
is: HMDB00230
is: CHEBI:35418
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial amount: NaN
name: N-acetylneuraminate
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR C4CRNCPT2
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of butyryl carnitine in the mitochondrial matrix for final hydrolysis
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_6f5f0ae1_7013_47d4_b321_38a9252cd9f5
type: Species
boundary condition: true
is: Q9UI40
has only substance units: false
is encoded by: hsa:25769
initial amount: NaN
name: SLC24A2
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_de7d33c9_b89f_4893_aa8f_782fc6cad688
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: PISD
is encoded by: hsa:23761
boundary condition: true
type: Species
is: Q9UG56

metaR NACHEXA12ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
type: Reaction
name: beta-N-acetylhexosaminidase A, lysosomal
is: SBO:0000176
kinetic law: MODEL1310110056#
reversible: false
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_e65a44ba_96ee_4051_9d16_aede19520c6e
is encoded by: hsa:3033
constant: false
is: SBO:0000252
boundary condition: true
type: Species
name: HADH
initial amount: NaN
is: Q16836
initial concentration: NaN
has only substance units: false

metaR r0679
product: MODEL1310110056#
modifier: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
reversible: true
reactant: MODEL1310110056#
is described by: ECO:0000000
kinetic law: MODEL1310110056#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
type: Reaction

metaM nadh c
name: Nicotinamide adenine dinucleotide - reduced
is: HMDB01487
is: CHEBI:57945
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/3306
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
is: C00004

http://identifiers.org/biomodels.db/MODEL1310110056#_64a1ae44_8b35_4244_bc26_4067767f9f4f
constant: false
initial amount: NaN
name: HADHA
has only substance units: false
is: E9KL44
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3030
is: SBO:0000252

metaR r0340
is version of: http://identifiers.org/ec-code/1.3.1.38
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
fast: false
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is: SBO:0000176
modifier: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_7cb7e2bb_eee4_4af9_b86f_dbc0c7646649
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10020
is: B7Z428
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species
name: GNE

metaM mag hs c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
constant: false
initial amount: NaN
type: Species
name: monoacylglycerol 2
is: SBO:0000247
boundary condition: false
is: CHEBI:60479

metaR r0754
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000176
reversible: true
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
kinetic law: MODEL1310110056#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR r0968
is described by: ECO:0000000
type: Reaction
reversible: false
name: Postulated transport reaction
product: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
kinetic law: MODEL1310110056#

metaR HISTAtu
kinetic law: MODEL1310110056#
reversible: true
reactant: MODEL1310110056#
modifier: MODEL1310110056#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
name: Histamine uniport
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_b6b29242_9098_4c20_89ff_233e3238a1b9
is: SBO:0000252
type: Species
initial amount: NaN
name: HSD17B4
boundary condition: true
has only substance units: false
is encoded by: hsa:3295
constant: false
initial concentration: NaN
is: E9PB82

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaR NADS2
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
name: NAD synthase (glutamine-hydrolysing)
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110056#
reversible: false
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/6.3.5.1
modifier: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#

metaM cdp m
boundary condition: false
is: HMDB01546
initial amount: NaN
is: SBO:0000247
name: CDP(3-)
constant: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: CHEBI:58069
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_3abeb5fa_047a_45df_87c2_afa8f5ab1594
is: P15954
boundary condition: true
initial concentration: NaN
name: COX7C
has only substance units: false
type: Species
is encoded by: hsa:1350
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_a594aa84_fa70_49dd_a911_0d60530942ef
is: Q16790
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
name: CA9
initial amount: NaN
is encoded by: hsa:768
constant: false
initial concentration: NaN

metaM cdp n
is: CHEBI:58069
constant: false
boundary condition: false
is: HMDB01546
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: CDP(3-)

metaM hpdca c
constant: false
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
initial concentration: 1.0
is: CHEBI:32366
has only substance units: false
type: Species
initial amount: NaN
name: margarate
is: SBO:0000247
boundary condition: false
is: HMDB02259

http://identifiers.org/biomodels.db/MODEL1310110056#_7a5c291f_93f0_410b_aeca_df56ad716abe
is: Q9NYR8
has only substance units: false
name: RDH8
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:50700

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaM f6p c
is: HMDB00124
is: SBO:0000247
name: D-Fructose 6-phosphate
type: Species
is: CHEBI:57579
is: http://identifiers.org/pubchem.compound/3385
initial concentration: 1.0
is: C00085
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_1679e4e9_530e_43dd_9ce9_754e267aef6f
initial amount: NaN
boundary condition: true
constant: false
is: P16260
is encoded by: hsa:8034
has only substance units: false
name: SLC25A16
type: Species
is: SBO:0000252
initial concentration: NaN

metaM nrvnccoa x
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: nervonyl coenzyme A
is: C16532
type: Species

metaR HPDCAt
is described by: ECO:0000000
reactant: MODEL1310110056#
name: fatty acid transport via diffusion
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
reversible: true
kinetic law: MODEL1310110056#
product: MODEL1310110056#

metaR GGH 6THFe
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (6THF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110056#
reversible: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000176
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_4df4afeb_9489_469a_a33e_82d40472088d
is: Q96M32
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: AK7
initial amount: NaN
is encoded by: hsa:122481
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_d5b0027c_a081_4379_8dab_b1ceca1b3535
is: SBO:0000297
is encoded by: hsa:93183
initial concentration: NaN
type: Species
initial amount: NaN
name: PIGX:PIGM
boundary condition: true
has part: Q9H3S5
is encoded by: hsa:54965
has only substance units: false
has part: Q8TBF5
constant: false

metaR OCD11CRNCPT2
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR GLYCt
is described by: ECO:0000000
name: glycerol transport via channel
fast: false
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110056#_1fb408c6_f461_46cd_9ab8_243e69353848
is: SBO:0000252
name: NAE1
type: Species
is encoded by: hsa:8883
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: A8MU28
initial amount: NaN

metaM mag hs e
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
has only substance units: false
type: Species
is: SBO:0000247
name: monoacylglycerol 2
is: CHEBI:60479
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_2092876a_c1db_401a_9f57_47f84e6d5030
constant: false
initial concentration: NaN
is encoded by: hsa:84129
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: ACAD11
type: Species
boundary condition: true
is: Q709F0

http://identifiers.org/biomodels.db/MODEL1310110056#_6bf693f1_c5a7_49f6_b218_2d22f16079e8
initial amount: NaN
is encoded by: hsa:1737
type: Species
has only substance units: false
initial concentration: NaN
constant: false
name: DLAT
boundary condition: true
is: Q86YI5
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_a93e842b_aa51_443d_bbf8_a540cb295b19
is encoded by: hsa:5322
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
name: PLA2G5
is: P39877

http://identifiers.org/biomodels.db/MODEL1310110056#_068e369a_956b_4048_a89a_b3b09ad60685
initial amount: NaN
is encoded by: hsa:5139
type: Species
constant: false
is: Q14432
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
name: PDE3A

metaM tethex3coa x
initial concentration: 1.0
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
has only substance units: false
constant: false
is: SBO:0000247
type: Species
name: tetracosahexaenoyl coenzyme A
is: C16168
is: http://identifiers.org/pubchem.compound/47205478
boundary condition: false
initial amount: NaN
is: HMDB06243

metaM 3ivcrn c
is: C05998
initial amount: NaN
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/11966188
has only substance units: false
notes: FORMULA: C12H23NO5 CHARGE: 0
constant: false
is: SBO:0000247
boundary condition: false
name: 3-hydroxy-isovaleryl carnitine
is: HMDB06870

metaM clpndcoa c
boundary condition: false
type: Species
is: HMDB06267
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205476
constant: false
initial concentration: 1.0
is: C16166
name: clupanodonyl CoA
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110056#_b3604716_0983_47c3_a1f7_cf09f6dadb82
is: SBO:0000252
constant: false
is encoded by: hsa:55825
initial amount: NaN
is: Q9BY49
initial concentration: NaN
type: Species
boundary condition: true
name: PECR
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_4263ee0d_f157_4573_b279_41c3873c5e65
boundary condition: true
initial amount: NaN
is encoded by: hsa:7355
initial concentration: NaN
name: SLC35A2
constant: false
is: SBO:0000252
has only substance units: false
is: P78381
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_8443d200_1ebc_4069_8ad5_9735fa32ab61
name: PLCD4
type: Species
initial amount: NaN
is: Q9BRC7
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:84812
initial concentration: NaN
is: SBO:0000252

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

metaM phe L e
initial amount: NaN
name: L-phenylalanine
is: CHEBI:17295
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
type: Species
is: HMDB00159
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079

http://identifiers.org/biomodels.db/MODEL1310110056#_0ef88f22_a916_4e2f_a10c_fe220cc07a59
constant: false
is: SBO:0000252
is encoded by: hsa:257202
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: GPX6
boundary condition: true
type: Species
is: P59796

http://identifiers.org/biomodels.db/MODEL1310110056#_3f1cf5b6_69b7_4786_bd83_dba87bcbf4f5
is encoded by: hsa:728441
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: GGT2
type: Species
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_caf34394_2abe_4513_8552_c3617ecb6445
has only substance units: false
name: HSD3B2
is: P26439
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3284
constant: false
initial amount: NaN
type: Species
boundary condition: true

metaR OXAHCOtex
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: false
is described by: ECO:0000304
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (1836.1) or (10861.1) or (10861.3) or (10861.2) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
fast: false
name: oxalate transport via bicarbonate countertransport
reactant: MODEL1310110056#
type: Reaction
is: SBO:0000185

metaR SPH1Pte
name: sph1p transport
reversible: true
fast: false
reactant: MODEL1310110056#
is described by: ECO:0000000
product: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
type: Reaction
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_7064454a_a089_4073_90f1_33a50b8f85f9
is encoded by: hsa:7001
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: PRDX2
initial amount: NaN
boundary condition: true
is: P32119
is: SBO:0000252

metaR RE1522M
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
type: Reaction
reversible: true
product: MODEL1310110056#
is: SBO:0000176
modifier: MODEL1310110056#
name: RE1522
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110056#
is described by: ECO:0000000

metaR VACCt
fast: false
reactant: MODEL1310110056#
is described by: ECO:0000000
name: fatty acid transport via diffusion
kinetic law: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
product: MODEL1310110056#
is: SBO:0000185

metaM subeac c
notes: FORMULA: C8H12O4 CHARGE: -2
initial concentration: 1.0
name: suberic acid
is: HMDB00893
is: SBO:0000247
constant: false
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false

metaR CYSTA
type: Reaction
fast: false
modifier: MODEL1310110056#
product: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
name: cysteine transaminase
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
reversible: true
is described by: ECO:0000304
reactant: MODEL1310110056#

metaM tdcrn c
is: HMDB05066
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C21H41NO4 CHARGE: 0
name: myristoyl carnitine
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false

metaM 3ivcrn e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C12H23NO5 CHARGE: 0
constant: false
has only substance units: false
is: HMDB13336
is: SBO:0000247
type: Species
initial amount: NaN
name: 3-hydroxy-isovaleryl carnitine

metaR SERHL
reversible: false
product: MODEL1310110056#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:2674117 NOTES:MM
is version of: http://identifiers.org/ec-code/4.3.1.17
fast: false
is described by: ECO:0000269
name: L-Serine hydro-lyase
modifier: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_a3b6d95e_625a_440d_9fe6_f53452815637
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:79053
type: Species
name: ALG8
has only substance units: false

metaR NDPK1m
reactant: MODEL1310110056#
reversible: true
fast: false
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000254
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.4.6

http://identifiers.org/biomodels.db/MODEL1310110056#_434f93a5_723f_4213_b5ac_d073cdaa9dba
name: RDH14
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:57665
is: Q9HBH5
boundary condition: true
type: Species
initial amount: NaN

metaM lnlncacoa m
is: CHEBI:51985
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: alpha-Linolenoyl-CoA
boundary condition: false
is: HMDB06290
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
initial concentration: 1.0
type: Species

metaR PCHOL HStg
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
name: phosphatidylcholine scramblase
is described by: ECO:0000000
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
reversible: true
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_d72c23c8_7ad4_4259_bbb9_afcc7ed1066c
initial concentration: NaN
boundary condition: true
is: P27815
name: PDE4A
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5141
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_b695e48d_c4fd_4225_83a1_3ca329221162
is encoded by: hsa:6898
has only substance units: false
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is: P17735
name: TAT
initial amount: NaN
initial concentration: NaN

metaM s2l2n2m2m l
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C84H136N6O62 CHARGE: -2
has only substance units: false
is: CHEBI:30825
name: de-Fuc form of PA6 (w/o peptide linkage)
is: SBO:0000247
type: Species
constant: false
is: HMDB00573

metaR GGT6
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
reversible: true
is described by: ECO:0000000
fast: false
name: Gamma-glutamyltransferase
reactant: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110056#_ce6abf5d_024b_4666_b3f1_9ac94410cb18
is: Q6FGV9
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10654
initial amount: NaN
constant: false
type: Species
name: PMVK

metaR PEAMNO
modifier: MODEL1310110056#
is described by: ECO:0000304
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.4.3.21
fast: false
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.4
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.22
name: Phenethylamine oxidase

http://identifiers.org/biomodels.db/MODEL1310110056#_4b033d09_7300_41b5_97f4_460388bb58db
type: Species
constant: false
has only substance units: false
is encoded by: hsa:57419
initial concentration: NaN
name: SLC24A3
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q9HC58

metaM phe L c
is: SBO:0000247
name: L-phenylalanine
constant: false
initial amount: NaN
is: HMDB00159
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: CHEBI:17295
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0

metaR RPEc
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
reversible: true
product: MODEL1310110056#
name: ribulose 5-phosphate 3-epimerase

metaM leuktrC4 e
type: Species
initial concentration: 1.0
name: leukotriene C4(2-)
is: HMDB01198
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:57973
is: SBO:0000247
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
initial amount: NaN

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_249cb36c_2e4e_49d4_80f4_20332c447c86
boundary condition: true
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: SLC8A3
is: Q96QG2
is encoded by: hsa:6547

http://identifiers.org/biomodels.db/MODEL1310110056#_8e362af1_0846_4827_bb24_8e53a03a6ba7
boundary condition: true
is: Q92947
type: Species
constant: false
name: GCDH
is encoded by: hsa:2639
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_4003fd9a_5a9e_464a_9e7e_ddbf2db17c93
is encoded by: hsa:5230
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: PGK1
boundary condition: true
type: Species
is: P00558

http://identifiers.org/biomodels.db/MODEL1310110056#_b607c143_134a_4589_90d5_3a7479ba83f0
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: Q9H5J4
is encoded by: hsa:79071
is: SBO:0000252
name: ELOVL6

metaM itaccoa m
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
type: Species
is: HMDB03377
has only substance units: false
name: itaconyl-CoA(5-)
is: SBO:0000247
is: CHEBI:57381
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR ACP1 FMN
is described by: ECO:0000254
is: SBO:0000176
modifier: MODEL1310110056#
name: acid phosphatase (FMN)
kinetic law: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:8522318 NOTES:INVALID ECO TERM: IFH
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.2
reactant: MODEL1310110056#
fast: false
product: MODEL1310110056#

metaM tdcrn e
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C21H41NO4 CHARGE: 0
constant: false
name: myristoyl carnitine
is: HMDB05066
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_b711ec54_9771_4275_941f_f06d352cfe4e
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
constant: false
has part: Q5VYT2
initial concentration: NaN
is: SBO:0000297
boundary condition: true
is encoded by: hsa:4731
initial amount: NaN
has only substance units: false
is encoded by: hsa:4712
type: Species

metaM ksi pre30 g
initial concentration: 1.0
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: C00130
is: CHEBI:58053
has only substance units: false
type: Species
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 30
constant: false

metaR sink tetdec2coa LPAREN c RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDEC2COASINK
type: Reaction

metaR SERDGLYexR
kinetic law: MODEL1310110056#
name: D-Serine/Glycine reversible exchange
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
type: Reaction
is: SBO:0000185
reversible: true
modifier: MODEL1310110056#
fast: false
product: MODEL1310110056#

metaR 2AMACHYD
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:500639 NOTES:SAB see PMID 500639: this reaction is spontaneous
is: SBO:0000176
reactant: MODEL1310110056#
is described by: ECO:0000000
type: Reaction
name: 2-Aminoacrylate hydrolysis
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110056#_83ca3445_77dc_4d51_9f31_c64165d1f264
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
name: COX6A2
is: Q02221
is encoded by: hsa:1339
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_503de8ae_3dee_4a2e_9664_9c173d1cd4d4
has only substance units: false
initial amount: NaN
is: E7ET30
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:50808
boundary condition: true
constant: false
name: AK3

http://identifiers.org/biomodels.db/MODEL1310110056#_d1a7a3db_d854_4c54_a7c8_a75a05a7816d
has only substance units: false
name: SLC6A2
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:6530
initial amount: NaN
is: Q96KH8
boundary condition: true

metaM cspg e l
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:36005
is: HMDB02183
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
has only substance units: false
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
is: SBO:0000247
constant: false

metaM amet m
constant: false
has only substance units: false
boundary condition: false
type: Species
is: HMDB01185
is: SBO:0000247
name: S-Adenosyl-L-methionine
initial concentration: 1.0
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
initial amount: NaN
is: C00019
is: CHEBI:15414

metaM leuktrC4 c
is: HMDB01198
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:57973
is: SBO:0000247
name: leukotriene C4(2-)
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
boundary condition: false
has only substance units: false
type: Species

metaM vacccrn c
type: Species
constant: false
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB06351
is: SBO:0000247
name: Vaccenyl carnitine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_4867adc5_f7ee_4235_be5a_9161ce49f298
type: Species
boundary condition: true
constant: false
is: P23743
initial concentration: NaN
initial amount: NaN
name: DGKA
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1606

metaR r0755
kinetic law: MODEL1310110056#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110056#
reversible: true
is: SBO:0000176
product: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5

metaM hyptaur c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
is: SBO:0000247
has only substance units: false
is: HMDB00965
constant: false
is: CHEBI:16668
type: Species
boundary condition: false
name: Hypotaurine

metaM ksi deg2 l
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C241H384N17O210S12 CHARGE: -13
initial concentration: 1.0
is: HMDB00573
boundary condition: false
initial amount: NaN
is: CHEBI:30825
name: keratan sulfate I, degradation product 2
type: Species

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_6b3acc0f_0588_4bfa_82dd_34bbfdac275e
is encoded by: hsa:6185
is: P04844
is: SBO:0000252
boundary condition: true
has only substance units: false
name: RPN2
constant: false
type: Species
initial concentration: NaN
initial amount: NaN

metaM prostgf2 c
is: CHEBI:57404
is: HMDB01139
name: prostaglandin F2alpha(1-)
type: Species
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN

metaR COAtl
is described by: ECO:0000000
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
name: CoA transport in lysosome via diffusion
is: SBO:0000185
product: MODEL1310110056#
fast: false
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110056#_388ef237_e72a_422a_9bbf_f79a3913476e
constant: false
initial concentration: NaN
is encoded by: hsa:83715
is: SBO:0000252
name: ESPN
is: B1AK53
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaR RE3626M
kinetic law: MODEL1310110056#
reversible: false
product: MODEL1310110056#
name: RE3626
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110056#

metaM adrn c
type: Species
has only substance units: false
constant: false
name: adrenic acid
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
is: HMDB02226
initial amount: NaN
is: CHEBI:53487
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR HSAT1ly
fast: false
product: MODEL1310110056#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110056#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reactant: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
type: Reaction

metaR MM5cg
type: Reaction
fast: false
reversible: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
modifier: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.113
is described by: ECO:0000000
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
product: MODEL1310110056#

metaR r1600
kinetic law: MODEL1310110056#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR r1725
type: Reaction
product: MODEL1310110056#
is: SBO:0000185
reactant: MODEL1310110056#
reversible: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110056#

metaM fol e
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C19H18N7O6 CHARGE: -1
constant: false
name: Folate
is: SBO:0000247
boundary condition: false
is: HMDB00121
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_0e67bb10_f2b0_4931_919a_b89a8720116b
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: HK2
is: P52789
is encoded by: hsa:3099

metaM leuktrC4 r
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: CHEBI:57973
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01198
initial amount: NaN
name: leukotriene C4(2-)

metaR CHOLATEt
reversible: true
type: Reaction
is: SBO:0000185
name: cholate transport via bicarbonate countertransport
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
fast: false
product: MODEL1310110056#
reactant: MODEL1310110056#

metaR COAtm
fast: false
kinetic law: MODEL1310110056#
name: CoA transporter
product: MODEL1310110056#
is described by: ECO:0000269
modifier: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
reversible: true
is: SBO:0000185
type: Reaction

metaM 3bcrn c
constant: false
boundary condition: false
name: 3-hydroxy butyryl carnitine
is: HMDB04047
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C11H21NO5 CHARGE: 0
is: C14143
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_47753569_1c6d_4e09_bc2c_f11eee653069
boundary condition: true
constant: false
type: Species
has only substance units: false
is: Q14032
name: BAAT
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:570
is: SBO:0000252

metaR GALASE17ly
type: Reaction
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110056#
reversible: false
is: SBO:0000176
product: MODEL1310110056#
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false

metaM cdp e
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
name: CDP(3-)
initial concentration: 1.0
is: CHEBI:58069
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: HMDB01546
is: SBO:0000247
constant: false

metaM cspg e e
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
is: HMDB00630
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:16040
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110056#_a4276ab9_a4aa_4ea9_945a_3e1f544a9c24
boundary condition: true
name: BDH1
is encoded by: hsa:622
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM pmtcoa c
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: C00154
is: HMDB01338
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
name: Palmitoyl-CoA (n-C16:0CoA)
constant: false
is: CHEBI:3454
initial concentration: 1.0

metaM 4hexdtricoa m
is: HMDB02288
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247
name: 4,7,10-hexadecatrienoylcoa
type: Species

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_f7c7c9bf_4fd0_4721_a4fa_2bff15ce3a75
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3423
has only substance units: false
name: IDS
boundary condition: true
initial concentration: NaN
type: Species
is: B4DGD7
constant: false

metaR r1726
reactant: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110056#
name: Y+LAT2 Utilized transport
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_2f331baa_954f_4abe_80c5_5873bd6ebde8
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
name: _AA576959_1_c
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AA576959

metaM Ser Thr g
constant: false
has only substance units: false
notes: FORMULA: XH CHARGE: 0
name: protein-linked serine or threonine residue (O-glycosylation site)
initial amount: NaN
is: CHEBI:58336
is: SBO:0000247
is: HMDB00645
type: Species
boundary condition: false
initial concentration: 1.0

metaR ALAALACNc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: ALAALACNc
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_dffe912b_9cc7_4ada_a7a3_df5c2e9fa9d7
type: Species
is: SBO:0000252
name: SMPD3
is: A8K0T6
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:55512

metaR THYOXt
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
fast: false
reactant: MODEL1310110056#
name: T4 transport via bicarbonate countertransport
is: SBO:0000185
product: MODEL1310110056#
is described by: ECO:0000269

metaM prostgf2 e
name: prostaglandin F2alpha(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
boundary condition: false
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01139
is: SBO:0000247
is: CHEBI:57404

metaM nadh m
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide - reduced
has only substance units: false
is: C00004
is: http://identifiers.org/pubchem.compound/3306
is: HMDB01487
is: SBO:0000247
is: CHEBI:57945
type: Species
boundary condition: false
constant: false
initial amount: NaN

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaR r1937
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: false
product: MODEL1310110056#
kinetic law: MODEL1310110056#
name: Y+LAT2 Utilized transport
fast: false
reactant: MODEL1310110056#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_96968a5a_da6a_497a_b760_50798a5e6536
constant: false
type: Species
is encoded by: hsa:1716
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: DGUOK

http://identifiers.org/biomodels.db/MODEL1310110056#_c37b3508_beb5_451e_9127_98a8daa3452c
initial concentration: NaN
name: RDH10
constant: false
type: Species
boundary condition: true
initial amount: NaN
is: Q8IZV5
is: SBO:0000252
has only substance units: false
is encoded by: hsa:157506

metaR PI4PLC
is described by: ECO:0000269
reversible: false
is: SBO:0000176
name: phosphatidylinositol 4-phosphate phospholipase C
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.4.11
product: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_f9bfd91a_67f5_4334_8083_e02da545e22a
initial concentration: NaN
name: PAPSS1
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is: O43252
type: Species
is encoded by: hsa:9061

metaM 3bcrn e
boundary condition: false
name: 3-hydroxy butyryl carnitine
is: HMDB04047
type: Species
initial amount: NaN
initial concentration: 1.0
is: C14143
notes: FORMULA: C11H21NO5 CHARGE: 0
is: SBO:0000247
constant: false
has only substance units: false

metaM lnlncacoa c
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:51985
constant: false
is: HMDB06290
name: alpha-Linolenoyl-CoA
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
is: SBO:0000247

metaM ttetddcoa m
type: Species
constant: false
name: trans5,8tetradecadienoylcoa
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
initial amount: NaN
is: HMDB02288
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_53861764_a770_4649_bb45_2abf2932af8e
name: COX8A
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q53XN1
type: Species
constant: false
is encoded by: hsa:1351
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_c58182ef_922f_4ead_bf96_fb68fa2cc78c
is: Q9NY64
has only substance units: false
boundary condition: true
name: SLC2A8
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:29988
initial concentration: NaN

metaM cyan c
name: hydrogen cyanide
boundary condition: false
type: Species
constant: false
has only substance units: false
is: HMDB02084
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: CHEBI:18407
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_bc923a68_227c_4d7d_8a84_21786cf5d1b9
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
type: Species
name: _AI972237_1_c
is encoded by: hsa:AI972237
initial concentration: NaN

metaR CAt7r
type: Reaction
notes: GENE_ASSOCIATION: (6547.6) or (6547.4) or (6547.2) or (6546.1) or (6547.1) or (6547.5) or (6543.1) or (6547.3) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12406570,PMID:2484986 NOTES:MM
modifier: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000185
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
name: calcium / sodium antiporter (1:3), reversible
is described by: ECO:0000269
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110056#_05184e81_af91_4e15_bffd_d3a9f65598cd
has only substance units: false
is: P34949
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4351
name: MPI
is: SBO:0000252
initial amount: NaN
type: Species

metaR LALDO
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
is: SBO:0000176
kinetic law: MODEL1310110056#
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
fast: false
is described by: ECO:0000000
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
reactant: MODEL1310110056#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110056#_68216fa5_ee26_4543_a156_602a5a646004
is encoded by: hsa:10873
type: Species
name: ME3
boundary condition: true
is: Q6TCH8
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN

metaR HDDACBP
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR C141ACBP
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradecenoyl coa from mitochondria into cytosol
type: Reaction

metaM gtp n
initial concentration: 1.0
name: GTP(4-)
boundary condition: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
has only substance units: false
type: Species
initial amount: NaN
is: HMDB01273
constant: false
is: CHEBI:37565
is: SBO:0000247

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaM nrpphrsf e
name: Sulfate derivative of norepinephrine
type: Species
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/123747
has only substance units: false
initial amount: NaN
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
is: HMDB02062
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_7ec5f403_f3cf_412f_a56a_cabbbb2a8c10
has only substance units: false
is encoded by: hsa:55163
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is: Q9NVS9
boundary condition: true
initial concentration: NaN
name: PNPO

http://identifiers.org/biomodels.db/MODEL1310110056#_68b56517_9d92_4618_95bb_d77a411e15ee
type: Species
constant: false
initial concentration: NaN
name: ND5
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4540
is: P03915
has only substance units: false

metaR LEUTA
kinetic law: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.42
name: leucine transaminase
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
product: MODEL1310110056#
reactant: MODEL1310110056#
fast: false
reversible: true
modifier: MODEL1310110056#
type: Reaction
is described by: ECO:0000269

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaR r1604
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaR IDOAASE2ly
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
name: alpha-L-iduronidase, lysosomal
product: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.76

http://identifiers.org/biomodels.db/MODEL1310110056#_02b3088b_03f9_4fff_ac4b_43cf5e590b1f
has only substance units: false
is encoded by: hsa:6576
initial concentration: NaN
name: SLC25A1
initial amount: NaN
boundary condition: true
type: Species
is: D9HTE9
constant: false
is: SBO:0000252

metaR HEXDICOAACBP
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioyl coa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_fb104f74_2b84_413e_8fd2_e1f43eb08295
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3098
name: HK1
initial concentration: NaN
is: Q59FD4
initial amount: NaN
boundary condition: true
type: Species

metaM Ser Thr l
initial amount: NaN
has only substance units: false
name: protein-linked serine or threonine residue (O-glycosylation site)
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: XH CHARGE: 0
constant: false
is: HMDB00224
is: CHEBI:58190
boundary condition: false

metaM din e
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00071
type: Species
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
initial amount: NaN
constant: false
is: CHEBI:28997
name: Deoxyinosine
is: C05512
initial concentration: 1.0

metaR SUCOAS1m
product: MODEL1310110056#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110056#
type: Reaction
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
reactant: MODEL1310110056#
modifier: MODEL1310110056#
name: Succinate--CoA ligase (GDP-forming)

metaR r1722
is described by: ECO:0000000
modifier: MODEL1310110056#
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110056#
product: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false

metaR r1605
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM glyc R m
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:16659
initial amount: NaN
initial concentration: 1.0
name: D-glycerate
boundary condition: false
is: HMDB00139
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_37657a87_34fd_4a6e_97e4_91a10677cda8
is encoded by: hsa:29880
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is: Q9Y673
type: Species
is: SBO:0000252
name: ALG5

metaM cyan e
initial concentration: 1.0
constant: false
is: HMDB02084
name: hydrogen cyanide
is: CHEBI:18407
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
type: Species
is: SBO:0000247

metaM ddece1crn e
notes: FORMULA: C19H35NO4 CHARGE: 0
initial concentration: 1.0
boundary condition: false
is: C02838
type: Species
is: HMDB00791
is: SBO:0000247
has only substance units: false
constant: false
name: dodecenoyl carnitine
initial amount: NaN

metaM adrn e
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:53487
initial amount: NaN
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
is: HMDB02226
type: Species
name: adrenic acid

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaR EX retinol cis 11 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cis-11-retinol exchange
type: Reaction

metaM nrpphrsf c
has only substance units: false
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/123747
boundary condition: false
is: SBO:0000247
name: Sulfate derivative of norepinephrine
initial amount: NaN
is: HMDB02062
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
type: Species

metaR FAOXC4C4DCc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: succ-->C4DCc
type: Reaction

metaR IPDPtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
reversible: true
is: SBO:0000185
name: Isopentenyl diphosphate transport (peroxisome)
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
fast: false
product: MODEL1310110056#
type: Reaction

metaM fol c
initial concentration: 1.0
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00121
has only substance units: false
constant: false
name: Folate

metaM acnam n
is: SBO:0000247
name: N-acetylneuraminate
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00230
has only substance units: false
is: CHEBI:35418
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial amount: NaN
constant: false

metaR r1602
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110056#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_b98d1f4b_4e02_4e20_8b8d_b89e75c6b8d8
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: O60331
boundary condition: true
is: SBO:0000252
is encoded by: hsa:23396
name: PIP5K1C

http://identifiers.org/biomodels.db/MODEL1310110056#_a3ffbaa9_5c33_4961_92fc_0583a9be875a
name: ECI1
constant: false
boundary condition: true
type: Species
is: P42126
is encoded by: hsa:1632
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR ADPCOAPTE
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of adipoyl coA for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_1f23a671_4643_4e43_af55_a08656bf0f4b
type: Species
name: SULT1A2
constant: false
is encoded by: hsa:6799
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM cdp c
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: HMDB01546
is: CHEBI:58069
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: CDP
boundary condition: false
is: SBO:0000247
is: C00112

http://identifiers.org/biomodels.db/MODEL1310110056#_4cae6daa_0a77_4dd4_a5a6_d72dc3c87f4f
type: Species
is encoded by: hsa:3707
has only substance units: false
initial amount: NaN
boundary condition: true
is: P27987
name: ITPKB
is: SBO:0000252
constant: false
initial concentration: NaN

metaR r0450
kinetic law: MODEL1310110056#
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.3

metaR EX adrn LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adrenic acid exchange
type: Reaction

metaR r1934
is described by: ECO:0000000
product: MODEL1310110056#
reactant: MODEL1310110056#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction
modifier: MODEL1310110056#
reversible: false

metaM gtp m
boundary condition: false
constant: false
is: SBO:0000247
is: C00044
name: GTP
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
has only substance units: false
type: Species
is: CHEBI:37565
initial amount: NaN
is: HMDB01273
initial concentration: 1.0

metaM occoa c
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
constant: false
initial concentration: 1.0
name: Octanoyl-CoA (n-C8:0CoA)
is: C01944
is: HMDB01070
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:57386

metaR r1603
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reversible: true
reactant: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaR S6T8g
reactant: MODEL1310110056#
fast: false
is: SBO:0000176
modifier: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
kinetic law: MODEL1310110056#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_7e61f821_ebd6_4120_894e_cf39d298c551
boundary condition: true
constant: false
is encoded by: hsa:23517
type: Species
is: SBO:0000252
name: SKIV2L2
initial concentration: NaN
is: Q3MHC9
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_3492e917_d794_42d6_9146_ec03ec960462
is encoded by: hsa:80339
is: SBO:0000252
is: Q9NST1
name: PNPLA3
constant: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_f02433ab_6c9e_4614_ba0e_2b0a15b4daff
initial amount: NaN
constant: false
name: _AI697028_1_m
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:AI697028

http://identifiers.org/biomodels.db/MODEL1310110056#_6675fd4a_410d_48f4_85b6_51765ceac63e
initial amount: NaN
name: AHCY
is encoded by: hsa:191
is: SBO:0000252
has only substance units: false
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is: B3KUN3

metaR KCC2t
is described by: ECO:0000269
fast: false
reactant: MODEL1310110056#
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110056#
name: K+-Cl- cotransporter (NH4+)
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
product: MODEL1310110056#
modifier: MODEL1310110056#

metaM 5aop m
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
boundary condition: false
is: CHEBI:17549
initial amount: NaN
initial concentration: 1.0
is: HMDB01149
is: C00430
name: 5-Amino-4-oxopentanoate
constant: false

metaM eicostetcoa m
is: C16164
name: eicosatetranoyl coenzyme A
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1

metaM c6crn c
notes: FORMULA: C13H25NO4 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: hexanoyl carnitine
boundary condition: false
is: HMDB00705
has only substance units: false
type: Species
constant: false

metaM 11 cis retfa e
boundary condition: false
has only substance units: false
name: fatty acid 11-cis-retinol
is: SBO:0000247
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
type: Species
is: CHEBI:58190
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00224

metaR P45027A11m
kinetic law: MODEL1310110056#
type: Reaction
fast: false
reactant: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000269
modifier: MODEL1310110056#
reversible: false
is: SBO:0000176

metaR THRD L
kinetic law: MODEL1310110056#
product: MODEL1310110056#
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 4.3.1.19 Confidence Level: 4 AUTHORS: PMID:12361482 NOTES:Previous EC number: 4.2.1.16. New EC number 4.3.1.19. Can't enter this....
reversible: false
is described by: ECO:0000269
type: Reaction
name: L-threonine deaminase
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/4.3.1.17
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110056#_db05c277_2ff7_4d60_afb0_9dca7a52ecf1
initial concentration: NaN
is: Q99714
initial amount: NaN
is encoded by: hsa:3028
has only substance units: false
name: HSD17B10
is: SBO:0000252
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_329fbb36_6566_4565_b724_af818b20382e
initial concentration: NaN
name: MYO5B
is encoded by: hsa:4645
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: Q9H6Y6
is: SBO:0000252
type: Species

metaM lthstrl r
is: CHEBI:17168
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
type: Species
name: 5alpha-cholest-7-en-3beta-ol
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB01170
is: SBO:0000247

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

metaR r2335
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_ce3872a2_77d5_4791_b163_ef151b7e4105
initial amount: NaN
type: Species
is: Q9H2B4
name: SLC26A1
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10861

metaM ksi pre11 g
constant: false
is: SBO:0000247
is: CHEBI:28067
initial amount: NaN
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 11

metaR r2338
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
fast: false
kinetic law: MODEL1310110056#
is: SBO:0000185
product: MODEL1310110056#
is described by: ECO:0000000
reactant: MODEL1310110056#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_991c1995_a144_49bf_bd93_5228324b1f1e
type: Species
constant: false
initial amount: NaN
is: Q9H903
is: SBO:0000252
name: MTHFD2L
initial concentration: NaN
is encoded by: hsa:441024
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_096bf3f9_7e4c_41dc_a02c_e3e4262472c2
is: SBO:0000252
boundary condition: true
name: ND3
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:4537
is: P03897
type: Species

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaM din c
initial amount: NaN
is: SBO:0000247
is: C05512
has only substance units: false
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
name: Deoxyinosine
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00071
constant: false
is: CHEBI:28997

metaR SLDx
name: L-sulfolactate dehydrogenase (NAD+)
notes: GENE_ASSOCIATION: (4190.1) or (130752.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.272 Confidence Level: 2 AUTHORS: PMID:15758220,PMID:3346220 NOTES:AMF EC: 1.1.1.272
kinetic law: MODEL1310110056#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.37
product: MODEL1310110056#
type: Reaction
fast: false
reactant: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000304

metaM c6crn e
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C13H25NO4 CHARGE: 0
initial concentration: 1.0
is: HMDB00705
name: hexanoyl carnitine
boundary condition: false
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_61365e44_4fca_4115_860e_564ce5d74691
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:N63787
constant: false
initial concentration: NaN
name: _N63787_1_c
is: SBO:0000252

metaM pmtcoa m
is: CHEBI:57379
boundary condition: false
name: Palmitoyl-CoA (n-C16:0CoA)
is: C00154
initial amount: NaN
is: SBO:0000247
is: HMDB01338
constant: false
type: Species
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
has only substance units: false
initial concentration: 1.0

metaM ksii core4 deg3 l
type: Species
initial amount: NaN
has only substance units: false
name: keratan sulfate II (core 4-linked), degradation product 3
initial concentration: 1.0
boundary condition: false
is: HMDB00143
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
is: SBO:0000247
constant: false
is: CHEBI:12936

metaR COAtr
product: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000185
reversible: true
name: COA transporter, endoplasmic reticulum
kinetic law: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
type: Reaction
is described by: ECO:0000000

metaR H2Oter
name: H2O endoplasmic reticulum transport
kinetic law: MODEL1310110056#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
reactant: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000185

metaR RE2985X
is version of: http://identifiers.org/ec-code/1.17.99.3
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: false
fast: false
is described by: ECO:0000000
reactant: MODEL1310110056#
type: Reaction
name: RE2985
product: MODEL1310110056#
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (8310.1) or (8309.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110056#_cdab24fe_1b0e_4b48_9422_70606ff6f790
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:52
type: Species
initial amount: NaN
is: SBO:0000252
is: P24666
initial concentration: NaN
name: ACP1

http://identifiers.org/biomodels.db/MODEL1310110056#_ffb32549_dc83_4fd4_a4f7_9170ef97b973
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is: Q9NSC7
boundary condition: true
is encoded by: hsa:55808
name: ST6GALNAC1

metaR FAOXC204184m
is: SBO:0000176
name: Beta oxidation fatty acid
product: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
is described by: ECO:0000000
modifier: MODEL1310110056#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 rounds of beta ox c20:4 -> c18:4 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1

metaM nicrnt c
is: CHEBI:57502
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB01132
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
name: Nicotinate D-ribonucleotide
is: C01185

http://identifiers.org/biomodels.db/MODEL1310110056#_56f37192_98d8_4dfc_8848_27deb490b36e
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10993
is: P20132
boundary condition: true
constant: false
initial concentration: NaN
type: Species
name: SDS

http://identifiers.org/biomodels.db/MODEL1310110056#_dd90b41f_ea33_4d8b_8547_62400fe25524
is: Q15067
has only substance units: false
name: ACOX1
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:51
is: SBO:0000252
constant: false
initial amount: NaN

metaR r0456
type: Reaction
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
fast: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.1.32

metaM tymsf c
is: HMDB06409
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
is: SBO:0000247
initial concentration: 1.0
type: Species
name: Tyramine O-sulfate
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false

metaM tethex3coa c
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
has only substance units: false
boundary condition: false
is: C16168
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205478
type: Species
initial concentration: 1.0
is: HMDB06243
initial amount: NaN
name: tetracosahexaenoyl coenzyme A

metaM 4fumacac c
boundary condition: false
name: 4-fumarylacetoacetate(2-)
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
is: HMDB01268
constant: false
is: CHEBI:18034
initial concentration: 1.0
is: SBO:0000247

metaR XOLTRIOLtm
fast: false
type: Reaction
kinetic law: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reversible: true
product: MODEL1310110056#
name: lipid, flip-flop intracellular transport

metaR DOLPMT2 Uer
product: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
is described by: ECO:0000000
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
kinetic law: MODEL1310110056#
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110056#_e792f589_ea05_4b07_81c5_6329fc6c5086
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: SLC6A8
type: Species
is encoded by: hsa:6535
initial amount: NaN
boundary condition: true
is: B4DIA3
constant: false

metaR r2332
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
kinetic law: MODEL1310110056#

metaR EX hexc LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexacosanoate (n-C26:0) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_2a51dd58_bb61_4d33_b307_bf015b31d9a5
has only substance units: false
is: Q9BW60
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: ELOVL1
initial amount: NaN
is encoded by: hsa:64834

metaM hs deg5 l
is: SBO:0000247
has only substance units: false
is: CHEBI:17895
is: HMDB00158
initial amount: NaN
name: heparan sulfate, degradation product 5
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
boundary condition: false
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_442b91de_4f89_4542_a785_2368c225a8d6
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
name: ALDH5A1
is encoded by: hsa:7915
is: Q546H9
type: Species
has only substance units: false
initial concentration: NaN

metaR G14T7g
fast: false
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
product: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110056#_9b5ad952_932a_49db_b497_e24b3cc2a0dd
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: O75874
name: IDH1
is: SBO:0000252
is encoded by: hsa:3417
constant: false

metaM dgsn m
is: C00330
is: CHEBI:17172
is: HMDB00085
is: SBO:0000247
boundary condition: false
name: Deoxyguanosine
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330

http://identifiers.org/biomodels.db/MODEL1310110056#_05c2e517_e13d_443c_b3b1_38e2f1db96b4
type: Species
constant: false
is: Q9BVK2
is: SBO:0000252
boundary condition: true
has only substance units: false
name: ALG8
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:79053

metaM dolmanp L c
is: SBO:0000247
type: Species
name: Dolichyl phosphate D-mannose, human liver homolog
has only substance units: false
initial concentration: 1.0
is: CHEBI:15809
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
boundary condition: false
constant: false
initial amount: NaN

metaM ksi pre4 g
type: Species
initial concentration: 1.0
is: C00130
boundary condition: false
notes: FORMULA: C101H165N7O72X CHARGE: -1
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00175
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 4

metaR r2331
is described by: ECO:0000000
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110056#
product: MODEL1310110056#
fast: false
reversible: true

metaM HC02214 e
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
has only substance units: false
name: prostaglandin-f1alpha
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:28852

metaR SBT Dtde
reversible: true
product: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
is described by: ECO:0000134
name: D-sorbitol transport, extracellular
kinetic law: MODEL1310110056#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.

http://identifiers.org/biomodels.db/MODEL1310110056#_75708d24_4c54_4ac3_879a_2007c281d821
boundary condition: true
is encoded by: hsa:5330
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: Q59F77
is: SBO:0000252
constant: false
name: PLCB2

metaR COAtp
reactant: MODEL1310110056#
fast: false
is: SBO:0000185
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
name: coenzyme A transport, peroxisomal

metaR FAOXC142C122x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)x
type: Reaction

metaM omhpal r
is: HMDB06294
has only substance units: false
type: Species
initial concentration: 1.0
name: w-hydroxypalmiticacid
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C16H30O3 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110056#_b885f6ef_3999_4310_9be4_65402149f0b9
is: O95479
constant: false
is encoded by: hsa:9563
initial amount: NaN
type: Species
name: H6PD
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR NACASPtm
name: N-acetyl-L-aspartate transport (mitochondria to cytosol)
product: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11279290 NOTES:MM
fast: false
is: SBO:0000185
kinetic law: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_e196caab_f448_4f09_9ae6_5eb175d87ee0
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8790
boundary condition: true
initial concentration: NaN
name: FPGT
initial amount: NaN
is: O14772
constant: false

metaR MI14Ptn
type: Reaction
kinetic law: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000185
name: inositol 1,4-bisphosphate nuclear transport (diffusion)
reactant: MODEL1310110056#
reversible: true
product: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR PCm
fast: false
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
reversible: false
name: pyruvate carboxylase
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110056#
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/6.4.1.1
reactant: MODEL1310110056#
is: SBO:0000176
kinetic law: MODEL1310110056#

metaM man6p c
has only substance units: false
type: Species
is: HMDB01078
initial concentration: 1.0
boundary condition: false
constant: false
name: D-Mannose 6-phosphate
is: CHEBI:17369
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275

metaR r2334
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110056#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaM g3pc c
constant: false
name: sn-Glycero-3-phosphocholine
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00086
is: CHEBI:16870
has only substance units: false
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670
initial concentration: 1.0
is: SBO:0000247

metaR 3HLYTCL
is described by: ECO:0000269
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: NOTES:SAB
product: MODEL1310110056#
reactant: MODEL1310110056#
reversible: false
fast: false
name: 3-Hydroxy-L-tyrosine carboxy-lyase
is version of: http://identifiers.org/ec-code/4.1.1.28
kinetic law: MODEL1310110056#
type: Reaction
is: SBO:0000176

metaR S2TASE2ly
modifier: MODEL1310110056#
is: SBO:0000176
product: MODEL1310110056#
name: iduronate-2-sulfatase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
fast: false
kinetic law: MODEL1310110056#
type: Reaction
reversible: false
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.6.13

http://identifiers.org/biomodels.db/MODEL1310110056#_80228d24_4e5c_4b8b_afe3_5b8d4e453ed6
is: Q5TDP6
is: SBO:0000252
is encoded by: hsa:51557
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
name: LGSN
type: Species
has only substance units: false

metaR G13MT U
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110056#
reversible: false
type: Reaction
modifier: MODEL1310110056#
name: Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.132
is: SBO:0000176
reactant: MODEL1310110056#
product: MODEL1310110056#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_a8fa71c6_62f2_474e_a1dd_fab3c2bcadfb
type: Species
is: O95167
name: NDUFA3
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4696
initial concentration: NaN
is: SBO:0000252
constant: false

metaR BILGLCURtr
name: glucuronidated compound transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
product: MODEL1310110056#

metaM glu5sa m
type: Species
is: SBO:0000247
constant: false
is: CHEBI:17232
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
boundary condition: false
name: L-Glutamate 5-semialdehyde
is: HMDB02104
initial concentration: 1.0
is: C01165

http://identifiers.org/biomodels.db/MODEL1310110056#_97e5e104_a2d0_4856_9ea5_73e209a14bce
initial amount: NaN
type: Species
name: PIGA
is: P37287
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5277
initial concentration: NaN
constant: false
has only substance units: false

metaM dctp n
boundary condition: false
name: dCTP
has only substance units: false
constant: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00998
type: Species
is: C00458
is: CHEBI:16311

metaR r2333
type: Reaction
kinetic law: MODEL1310110056#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110056#
reactant: MODEL1310110056#
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM occoa m
name: Octanoyl-CoA (n-C8:0CoA)
type: Species
is: CHEBI:57386
is: HMDB01070
is: C01944
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944

metaR P45027A1m
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110056#
product: MODEL1310110056#
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
fast: false
reversible: false
is described by: ECO:0000269
is: SBO:0000176
name: Cytochrome P450 27

metaR INSTt4
modifier: MODEL1310110056#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110056#
product: MODEL1310110056#
name: inositol transport via sodium symport
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
kinetic law: MODEL1310110056#
reversible: true

metaM ksii core4 deg1 l
initial concentration: 1.0
is: CHEBI:57737
name: keratan sulfate II (core 4-linked), degradation product 1
is: HMDB00868
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C78H126N6O64S3X CHARGE: -3

metaR FAOXC5OHc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: (3-hydroxyisovalerylcoa-->3-hydroxyisovalerylcarnitine)c
type: Reaction

metaM HC02214 c
is: SBO:0000247
name: prostaglandin-f1alpha
has only substance units: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: CHEBI:28852

metaM ksi pre28 g
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00175
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
name: keratan sulfate I biosynthesis, precursor 28
initial concentration: 1.0
is: CHEBI:58053
is: C00130

metaM em2emgacpail prot hs r
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
is: CHEBI:16870
has only substance units: false
is: HMDB00086
constant: false
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2X CHARGE: 0

metaR COAtn
is described by: ECO:0000000
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110056#
fast: false
reactant: MODEL1310110056#
is: SBO:0000185
reversible: true
name: coenzyme A transport, nuclear
type: Reaction

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaR DM Lcystin
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for L-cystine
type: Reaction

metaM 4hbzcoa m
initial concentration: 1.0
constant: false
name: 4-hydroxybenoyl-CoA
is: HMDB06467
notes: FORMULA: C28H36N7O18P3S CHARGE: -4 INCHI: InChI=1/C28H40N7O18P3S/c1-28(2,22(39)25(40)31-8-7-18(37)30-9-10-57-27(41)15-3-5-16(36)6-4-15)12-50-56(47,48)53-55(45,46)49-11-17-21(52-54(42,43)44)20(38)26(51-17)35-14-34-19-23(29)32-13-33-24(19)35/h3-6,13-14,17,20-22,26,36,38-39H,7-12H2,1-2H3,(H,30,37)(H,31,40)(H,45,46)(H,47,48)(H2,29,32,33)(H2,42,43,44)/t17-,20?,21-,22+,26-/m1/s1
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_2b6dcc91_cedd_4967_8f15_be313700d309
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:10768
name: AHCYL1
boundary condition: true
initial amount: NaN
type: Species

metaM 3tdcrn e
notes: FORMULA: C21H41NO5 CHARGE: 0
is: SBO:0000247
name: 3-hydroxy-tetradecanoyl carnitine
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: HMDB13336
has only substance units: false
initial amount: NaN

metaM hs deg24 l
is: CHEBI:16126
type: Species
name: GlcNAc-GlcA-(Gal)2-Xyl
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C31H50NO26 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110056#_093dd7a3_7ff4_47b4_8bd6_c41c1dd8f44d
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: _AU149534_1_e
initial concentration: NaN
is encoded by: hsa:AU149534

metaR r1827
product: MODEL1310110056#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110056#
is: SBO:0000185
kinetic law: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
name: Y+LAT2 Utilized transport

metaR BUTt2r
fast: false
reactant: MODEL1310110056#
product: MODEL1310110056#
reversible: true
is described by: ECO:0000269
name: Butyrate transport via proton symport, reversible
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
kinetic law: MODEL1310110056#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110056#

metaM dctp c
is: HMDB00998
name: dCTP
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: C00458
has only substance units: false
type: Species
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: SBO:0000247
is: CHEBI:16311

http://identifiers.org/biomodels.db/MODEL1310110056#_8d393ba3_6ffc_4f56_aadb_d71254ba9884
boundary condition: true
is encoded by: hsa:3284
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is: P26439
name: HSD3B2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_f10f31d1_258f_4cff_aa45_c448383352cb
type: Species
has only substance units: false
is: P53396
initial concentration: NaN
constant: false
name: ACLY
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:47

metaM pmtcoa r
name: Palmitoyl-CoA (n-C16:0CoA)
has only substance units: false
initial concentration: 1.0
is: HMDB01338
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:3454
is: C00154
notes: FORMULA: C37H62N7O17P3S CHARGE: -4

metaM lnlccrn c
is: HMDB06469
constant: false
initial concentration: 1.0
name: Linoleyl carnitine
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
type: Species
is: SBO:0000247

metaM CE2838 e
name: maltononaose
has only substance units: false
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
initial concentration: 1.0
initial amount: NaN
constant: false
is: C01936
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
type: Species

metaM arachd c
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
is: HMDB01043
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:32395
constant: false
name: arachidonate

metaR TTDCAFATPc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaR RE3004M
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
reversible: true
name: RE3004
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR 3MOX4HOXPGALDOX NADP
type: Reaction
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
fast: false
product: MODEL1310110056#
modifier: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110056#_fdade133_1f6b_4214_abfa_da2bd3f64bbc
initial concentration: NaN
type: Species
is encoded by: hsa:2731
is: SBO:0000252
constant: false
name: GLDC
has only substance units: false
boundary condition: true
is: P23378
initial amount: NaN

metaM cs e deg6 l
is: HMDB00812
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C31H48NO32S2 CHARGE: -3
type: Species
is: CHEBI:16953
initial amount: NaN
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_3beda076_905f_4b30_9bb1_d3b8d2da7f97
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: CHAT
has only substance units: false
boundary condition: true
is: Q6LEN5
type: Species
is encoded by: hsa:1103
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_7c6c3e1f_ac78_4396_b850_ec7024d73733
has only substance units: false
initial concentration: NaN
constant: false
is: P15328
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: FOLR1
is encoded by: hsa:2348

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_9b81e5be_e9e1_4f39_9684_1e6b73420feb
initial amount: NaN
name: FUT8
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is: G3V5N0
type: Species
is encoded by: hsa:2530

metaR Htx
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
reversible: true
product: MODEL1310110056#
name: H transporter, peroxisome

metaR r2330
is described by: ECO:0000000
reactant: MODEL1310110056#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction
fast: false
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110056#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110056#_012214f2_9675_410d_bce8_2ec8958bbe91
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: NT5C1B
constant: false
is: B3KUK6
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:93034

http://identifiers.org/biomodels.db/MODEL1310110056#_6ddb46b2_eeed_4a09_b6ff_9d3976009cba
initial concentration: NaN
name: CEPT1
type: Species
initial amount: NaN
is: B3KN25
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:10390

http://identifiers.org/biomodels.db/MODEL1310110056#_c0d3f421_86c2_40cb_80e6_69cd0676437b
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is: P49753
initial amount: NaN
name: ACOT2
constant: false
is encoded by: hsa:10965
initial concentration: NaN

metaM dmnoncoa x
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
initial amount: NaN
is: SBO:0000247
name: 4,8 dimethylnonanoyl-CoA
initial concentration: 1.0
is: HMDB11604
type: Species
boundary condition: false
has only substance units: false
constant: false

metaR r0560
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
product: MODEL1310110056#
type: Reaction
reversible: false
reactant: MODEL1310110056#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110056#

metaR OCTAt
fast: false
reactant: MODEL1310110056#
is: SBO:0000185
name: Octanoate transport via diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
type: Reaction
reversible: true

metaR CMPSAS
type: Reaction
modifier: MODEL1310110056#
is: SBO:0000176
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.7.43
reversible: false
name: CMP sialic acid synthase
reactant: MODEL1310110056#
is described by: ECO:0000304
product: MODEL1310110056#
fast: false

metaR AG13T5g
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110056#
modifier: MODEL1310110056#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110056#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
kinetic law: MODEL1310110056#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110056#_5fecbcca_2283_45c5_9e0b_72335d7bb319
name: ACAT1
has only substance units: false
is: P24752
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:38
type: Species

metaM gmp c
is: SBO:0000247
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
name: GMP
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: HMDB01397
is: CHEBI:58115
constant: false
is: C00144
boundary condition: false

metaR r1824
fast: false
is: SBO:0000185
reactant: MODEL1310110056#
product: MODEL1310110056#
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110056#_8fa0080a_9d85_4095_93a0_8ceefbf661d9
has only substance units: false
initial concentration: NaN
is: O15305
constant: false
is encoded by: hsa:5373
type: Species
name: PMM2
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_a155ca4d_fb51_4b0b_a7d7_8334ae597c85
is: SBO:0000252
boundary condition: true
type: Species
name: NDUFS6
initial concentration: NaN
is: Q6IBC4
has only substance units: false
is encoded by: hsa:4726
initial amount: NaN
constant: false

metaR C142OHc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradeca dienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_08193f1f_18cd_4d69_9978_6e16f4173763
name: PLCB1
constant: false
is encoded by: hsa:23236
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species

metaM cysam c
constant: false
is: CHEBI:58029
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
initial concentration: 1.0
boundary condition: false
is: HMDB02991
initial amount: NaN
name: cysteaminium
is: SBO:0000247
type: Species
has only substance units: false

metaR RE3567C
product: MODEL1310110056#
is described by: ECO:0000000
kinetic law: MODEL1310110056#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
name: RE3567
reactant: MODEL1310110056#
type: Reaction
reversible: true

metaR FAOXC184C164x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_63850a3e_f390_4067_8c59_f38fe33c4fb1
constant: false
is: P34059
is encoded by: hsa:2588
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: GALNS
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_4aa32e0b_80c0_4dab_bfcb_d5c7f06b5504
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8818
type: Species
name: DPM2
has only substance units: false
constant: false
is: O94777
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_e0f30c5a_65b3_4926_a01a_8ca179451925
is encoded by: hsa:8876
is: SBO:0000252
has only substance units: false
boundary condition: true
is: O95497
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
name: VNN1

metaR SACCD3m
reactant: MODEL1310110056#
is described by: ECO:0000269
kinetic law: MODEL1310110056#
fast: false
is: SBO:0000176
modifier: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.8 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
is version of: http://identifiers.org/ec-code/1.5.1.8
type: Reaction
product: MODEL1310110056#
name: saccharopine dehydrogenase (NADP, L-lysine forming), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110056#_4ed1abd2_f763_4a42_8aae_8ce749189d33
has only substance units: false
type: Species
is: Q8WZ48
is encoded by: hsa:1374
constant: false
initial amount: NaN
name: CPT1A
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM pmtcoa x
has only substance units: false
name: Palmitoyl-CoA (n-C16:0CoA)
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: CHEBI:57379
is: SBO:0000247
is: HMDB01338
boundary condition: false
is: C00154
initial amount: NaN

metaM ksii core2 deg1 l
constant: false
is: SBO:0000247
is: HMDB00868
type: Species
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 1
initial concentration: 1.0
is: CHEBI:57737
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
initial amount: NaN
boundary condition: false

metaM prostgi2 e
is: HMDB01335
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin I2(1-)
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
type: Species
is: CHEBI:57403
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_65fcf16b_03b6_4640_a446_f2ba54582c4d
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaR FAOXC102C103m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaR RE1447M
fast: false
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.41
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
name: RE1447
is described by: ECO:0000000
reversible: true
is: SBO:0000176

metaR C142OHe
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:2-OH
type: Reaction

metaM hco3 c
is: HMDB00595
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: Bicarbonate
initial amount: NaN
is: C00288
is: CHEBI:17544
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_fe28fa19_1ef0_48f6_99f4_97e341d2f6f1
type: Species
has only substance units: false
is encoded by: hsa:2530
name: FUT8
constant: false
is: Q9BYC5
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM gmp e
constant: false
has only substance units: false
initial amount: NaN
name: GMP(3-)
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58115
type: Species
boundary condition: false
is: HMDB01397
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144

http://identifiers.org/biomodels.db/MODEL1310110056#_4a3bce84_a5c8_4502_96e0_85fed9d646bf
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR r0973
reversible: true
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
product: MODEL1310110056#
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: Facilitated diffusion
reactant: MODEL1310110056#

metaM 3tdcrn c
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: 3-hydroxy-tetradecanoyl carnitine
is: HMDB02014
has only substance units: false
constant: false
notes: FORMULA: C21H41NO5 CHARGE: 0
is: SBO:0000247

metaM prostgi2 c
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
has only substance units: false
is: CHEBI:57403
type: Species
is: HMDB01335
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin I2(1-)

http://identifiers.org/biomodels.db/MODEL1310110056#_bb02c3fb_59e7_4c1c_8090_1584976a12fa
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: ALG2
is encoded by: hsa:85365
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_ba498c90_4d66_4f17_9493_e8c17ca1d180
type: Species
is: Q16348
initial amount: NaN
boundary condition: true
name: SLC15A2
is encoded by: hsa:6565
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false

metaM 34dhoxmand c
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:27637
type: Species
name: 3,4-Dihydroxymandelate
initial amount: NaN
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
has only substance units: false
boundary condition: false
constant: false
is: HMDB01866

metaR r2045
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reversible: false
product: MODEL1310110056#
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_b7a1c8b4_f85c_424c_ab97_847fb621988f
has only substance units: false
is: O00443
is encoded by: hsa:5286
name: PIK3C2A
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_5e53770b_9228_4c80_b52c_6db5bd07f93f
initial amount: NaN
type: Species
name: ADH4
is: SBO:0000252
is: P08319
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:127
has only substance units: false

metaR CRNrtx
is described by: ECO:0000134
reactant: MODEL1310110056#
is: SBO:0000185
fast: false
name: reversible transport of L-Carnitine in peroxisome
product: MODEL1310110056#
reversible: true
kinetic law: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.

metaM eicostetcoa c
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
name: eicosatetranoyl coenzyme A
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
is: C16164
is: SBO:0000247
type: Species

metaR RE1447N
type: Reaction
fast: false
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
name: RE1447
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:

metaR r0345
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110056#
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
modifier: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.13
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110056#

metaR EX estradiol LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: estradiol exchange
type: Reaction

metaR SLDt
is: SBO:0000185
product: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15758220 NOTES:MM
type: Reaction
fast: false
name: L-sulfolactate transport (cytosol to extracellular)
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110056#

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_e374e117_2154_4631_a630_e90269e3d3d1
is: Q7GXY8
boundary condition: true
name: COX1
is encoded by: hsa:4512
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
constant: false
initial amount: NaN

metaM dgsn c
initial amount: NaN
is: HMDB00085
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
has only substance units: false
type: Species
boundary condition: false
is: C00330
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Deoxyguanosine
is: CHEBI:17172

metaM arachd e
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:32395
boundary condition: false
initial concentration: 1.0
name: arachidonate
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
type: Species
is: HMDB01043

metaR r0974
fast: false
is: SBO:0000185
product: MODEL1310110056#
name: Active transport
reversible: true
reactant: MODEL1310110056#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
kinetic law: MODEL1310110056#

metaR GLNS
is version of: http://identifiers.org/ec-code/4.1.1.15
reversible: false
name: glutamine synthetase
product: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000254
is: SBO:0000176
fast: false
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_3914a1c3_d6f2_46ae_9608_02bebd9511a0
has only substance units: false
initial amount: NaN
name: CHST3
is: SBO:0000252
boundary condition: true
is: Q7LGC8
type: Species
is encoded by: hsa:9469
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_10dc1c1b_43ef_40c9_ad6a_2cfbadff8998
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:411
is: SBO:0000252
is: P15848
constant: false
boundary condition: true
type: Species
name: ARSB

http://identifiers.org/biomodels.db/MODEL1310110056#_72374d10_e98d_4090_93f3_9282e32cdb35
is encoded by: hsa:6517
is: P14672
initial amount: NaN
type: Species
constant: false
name: SLC2A4
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR r2044
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaM hco3 e
boundary condition: false
type: Species
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: Bicarbonate
is: C00288
constant: false
is: HMDB00595
is: CHEBI:17544

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaM gmp g
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
initial amount: NaN
is: SBO:0000247
name: GMP(3-)
has only substance units: false
is: HMDB01397
initial concentration: 1.0
type: Species
is: CHEBI:58115
boundary condition: false
constant: false

metaR KSII CORE2t
name: keratan sulfate II (core2) transport, golgi to extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110056#
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110056#
is described by: ECO:0000000
reactant: MODEL1310110056#
reversible: false

metaR OCT11EFATP
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of vaccenic acid by cells
type: Reaction

metaR GTHDH
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
fast: false
name: Glutathione dehydrogenase (dehydroascorbate reductase)
reactant: MODEL1310110056#
product: MODEL1310110056#
reversible: false
is described by: ECO:0000134
kinetic law: MODEL1310110056#
is: SBO:0000176

metaR LTC4Sr
kinetic law: MODEL1310110056#
product: MODEL1310110056#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (4056.1) or (4259.1) or (4056.2) or (4258.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 4.4.1.20 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:previous EC 2.5.1.37 EC: 4.4.1.20 NJ
reactant: MODEL1310110056#
is: SBO:0000176
modifier: MODEL1310110056#
name: Leukotriene C4 synthase
type: Reaction
is version of: http://identifiers.org/ec-code/2.5.1.18
is version of: http://identifiers.org/ec-code/4.4.1.20
is described by: ECO:0000269

metaR FACOAL1813
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110056#
product: MODEL1310110056#
name: fatty-acid--CoA ligase
fast: false
modifier: MODEL1310110056#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaM dolmanp L r
name: Dolichyl phosphate D-mannose, human liver homolog
is: CHEBI:15809
boundary condition: false
constant: false
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_f0cfd467_07cd_4a5a_b12f_b22898d5f61c
boundary condition: true
initial concentration: NaN
is: Q96RQ3
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:56922
name: MCCC1
is: SBO:0000252

metaM octdececrn m
constant: false
is: HMDB06351
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0
has only substance units: false
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
initial amount: NaN
type: Species

metaR CYTK13
is described by: ECO:0000269
product: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000176
type: Reaction
reversible: true
name: cytidylate kinase (dCMP,dATP)
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110056#

metaR NMNATn
notes: GENE_ASSOCIATION: (64802.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.7.1 Confidence Level: 4 AUTHORS: PMID:11027696,PMID:11248244,PMID:12574164 NOTES:IT
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.1
fast: false
reactant: MODEL1310110056#
name: nicotinamide-nucleotide adenylyltransferase
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
is: SBO:0000176

metaM ppi r
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
constant: false
is: C00013
is: CHEBI:33019
is: HMDB00250
initial amount: NaN
name: Diphosphate
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR r2084
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110056#
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
reversible: true
fast: false
is described by: ECO:0000000

metaR r1630
reactant: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110056#
is: SBO:0000185
kinetic law: MODEL1310110056#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM oxa e
is: HMDB02329
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: CHEBI:30623
constant: false
boundary condition: false
name: oxalate(2-)
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR C4x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of butyrylcoa to butyrylcarnitine for transport
type: Reaction

metaR MTHFD2m
product: MODEL1310110056#
fast: false
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.5.4.9
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
reversible: true
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
is: SBO:0000176

metaR MMSAD1m
fast: false
modifier: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
name: methylmalonate-semialdehyde dehydrogenase
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
product: MODEL1310110056#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.27
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_a0db5859_2c99_4539_b9cd_316bc61dc03c
is encoded by: hsa:64802
has only substance units: false
initial concentration: NaN
name: NMNAT1
type: Species
is: B1AN63
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false

metaR q10h2tc
reversible: true
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110056#
name: transport of ubiquinol into cytosol
is: SBO:0000185

metaM sphs1p e
type: Species
constant: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
name: sphingosine 1-phosphate(1-)
is: CHEBI:60119
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00277

metaR ACCOAtr
is described by: ECO:0000000
product: MODEL1310110056#
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ changed name from ACCOArt to ACCOAtr for consistency - NCD
reactant: MODEL1310110056#
type: Reaction
is: SBO:0000185
name: acetyl-coa transport
fast: false
kinetic law: MODEL1310110056#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110056#_712d5b31_1476_403d_983e_b18fa50642a9
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5297
is: B4DYG5
name: PI4KA
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true

metaR FACOAL1812
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
product: MODEL1310110056#
name: fatty-acid--CoA ligase

metaR C2tcx
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of acetylcarnitine from peroxisomes to cytosol
type: Reaction

metaR CYTK12
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110056#
reversible: true
is described by: ECO:0000269
name: cytidylate kinase (dCMP,dCTP)
product: MODEL1310110056#
reactant: MODEL1310110056#

metaR RE1796M
product: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
reactant: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000176
name: RE1796
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.145
type: Reaction
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110056#_81f09f12_4c1b_4544_9771_4895f54ffb12
is: SBO:0000252
constant: false
initial amount: NaN
name: NDUFS4
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:4724
is: O43181
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_4c6c0e35_ca11_42fd_b95c_361e75283312
boundary condition: true
is: Q5JPA4
initial concentration: NaN
type: Species
is encoded by: hsa:53919
constant: false
name: SLCO1C1
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM dolp L c
has only substance units: false
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial amount: NaN
boundary condition: false
type: Species
name: dolichyl phosphate(2-)
initial concentration: 1.0
is: CHEBI:57683
is: SBO:0000247
constant: false

metaR r2085
reactant: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110056#
is described by: ECO:0000000
kinetic law: MODEL1310110056#

metaR r1631
product: MODEL1310110056#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110056#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_38e65f94_a7f1_4e26_bcb5_048237dcc176
name: ACOX3
initial amount: NaN
is encoded by: hsa:8310
is: O15254
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_ec6d2299_8fb8_459f_b3cb_d300813abca9
name: PIGF
boundary condition: true
is: Q6IB04
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5281
type: Species

metaR RE1233C
name: RE1233
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110056#
fast: false
product: MODEL1310110056#
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000176
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
is version of: http://identifiers.org/ec-code/2.6.1.64

metaM dhf c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
constant: false
is: SBO:0000247
is: C00415
name: 7,8-Dihydrofolate
boundary condition: false
is: HMDB01056
is: CHEBI:57451
type: Species
initial amount: NaN

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_32b92bb6_49f7_43e8_86ab_ae811c59df92
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: P00533
initial amount: NaN
is encoded by: hsa:1956
constant: false
is: SBO:0000252
name: EGFR

http://identifiers.org/biomodels.db/MODEL1310110056#_d03c8c4b_f8ed_4ca2_b4ab_564545b6d145
is: Q9GZX3
constant: false
is: SBO:0000252
has only substance units: false
type: Species
name: CHST6
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4166

metaM dcacoa m
is: HMDB06404
type: Species
has only substance units: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
constant: false
boundary condition: false
name: Decanoyl-CoA (n-C10:0CoA)
initial amount: NaN
initial concentration: 1.0
is: C05274
is: CHEBI:61430
is: SBO:0000247

metaR r2086
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110056#
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110056#

metaR GALC
is version of: http://identifiers.org/ec-code/3.2.1.46
reversible: false
reactant: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110056#
product: MODEL1310110056#
kinetic law: MODEL1310110056#
name: Galactocerebrosidase
notes: GENE_ASSOCIATION: (2581.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.46 Confidence Level: 4 AUTHORS: PMID:7601472 NOTES:NJ
is: SBO:0000176
fast: false

metaM xoltriol c
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
initial amount: NaN
boundary condition: false
is: CHEBI:16496
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB01457

metaR CYTK11
name: cytidylate kinase (dCMP,dGTP)
product: MODEL1310110056#
is described by: ECO:0000269
reactant: MODEL1310110056#
reversible: true
is: SBO:0000176
type: Reaction
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false

metaR r1632
kinetic law: MODEL1310110056#
product: MODEL1310110056#
modifier: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110056#
type: Reaction
fast: false

metaR r1846
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110056#
reversible: false
is described by: ECO:0000000
fast: false

metaM cs b deg1 l
has only substance units: false
initial concentration: 1.0
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
initial amount: NaN
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
boundary condition: false
is: SBO:0000247
is: HMDB00812
type: Species
is: CHEBI:16953
constant: false

metaM HC01434 x
initial concentration: 1.0
is: SBO:0000247
constant: false
name: oxalatosuccinate(3-)
is: CHEBI:58931
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_2cbe4652_860b_4878_a632_011695ce2763
constant: false
boundary condition: true
has only substance units: false
name: GNS
initial concentration: NaN
is encoded by: hsa:2799
is: SBO:0000252
is: Q7Z3X3
type: Species
initial amount: NaN

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaR r2087
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reversible: true
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110056#
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#

metaR ARGtm
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110056#
reversible: true
name: arginine mitochondrial transport via ornithine carrier
fast: false
product: MODEL1310110056#

metaM sphs1p c
is: HMDB00277
type: Species
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
name: sphingosine 1-phosphate(1-)
constant: false
has only substance units: false
is: CHEBI:60119
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR EX 3ivcrn
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-isovaleryl carnitine
type: Reaction

metaM acald c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
name: acetaldehyde
constant: false
has only substance units: false
boundary condition: false
is: HMDB00990
is: SBO:0000247
is: CHEBI:15343
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_63d23fc1_a0bd_4320_ac76_c3d0fe6efa92
boundary condition: true
name: NDUFS4
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4724
is: SBO:0000252
has only substance units: false
is: O43181

metaM gln L m
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00641
name: L-glutamine
is: CHEBI:18050
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR CYTK10
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,dGTP)
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reversible: true
is: SBO:0000176
type: Reaction
product: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000269

metaR RE2079R
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
product: MODEL1310110056#
name: RE2079

http://identifiers.org/biomodels.db/MODEL1310110056#_b182b8e5_47fd_4019_b2ad_9587f60eeacc
is: Q15147
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5332
name: PLCB4
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_293e7ea6_dd34_4897_9c42_44ce215c72aa
name: UAP1L1
is encoded by: hsa:91373
is: Q3KQV9
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_d2f48be0_a58b_4a1a_802c_fa7cce294b06
name: _AI620219_1_c
is encoded by: hsa:AI620219
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
type: Species

metaR r1633
is described by: ECO:0000000
reactant: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true

metaM ficytC m
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
initial amount: NaN
type: Species
is: CHEBI:15991
constant: false
name: Ferricytochrome c

metaR r1908
name: Y+LAT2 Utilized transport
reactant: MODEL1310110056#
modifier: MODEL1310110056#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
type: Reaction
is: SBO:0000185

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaR PUNP1
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
fast: false
reactant: MODEL1310110056#
reversible: true
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Adenosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase

metaM ser L c
initial concentration: 1.0
constant: false
name: L-serine
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: CHEBI:17115
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00187
type: Species

metaR r0788
is: SBO:0000176
product: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110056#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110056#_ed2fdc87_5775_4d11_9fb4_9acf2b0b64f3
is: Q9BZX2
name: UCK2
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:7371
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_cff4f38e_8a4c_4468_a31e_e184c28ecee6
initial amount: NaN
is encoded by: hsa:AV717590
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: _AV717590_1_c
type: Species

metaM sbt D e
name: D-glucitol
is: SBO:0000247
is: HMDB00247
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
constant: false
initial amount: NaN
type: Species

metaR ACGPID
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.5.1.89
product: MODEL1310110056#
modifier: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
is described by: ECO:0000269
fast: false
is: SBO:0000176
reversible: false
type: Reaction
name: N-acetylglucosaminylphosphatidylinositol deacetylase

metaR ASPTAm
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
name: aspartate transaminase
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#

metaR r2088
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
reactant: MODEL1310110056#
type: Reaction
reversible: true
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110056#
is described by: ECO:0000000

metaR FAOXC164C165x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)x
type: Reaction

metaR PUNP2
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reversible: true
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110056#
name: purine-nucleoside phosphorylase (Deoxyadenosine)
is: SBO:0000176
reactant: MODEL1310110056#
fast: false
modifier: MODEL1310110056#

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

metaM ppi n
initial concentration: 1.0
constant: false
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:33019
initial amount: NaN
name: diphosphate(3-)
boundary condition: false

metaR r0787
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
fast: false
is: SBO:0000176
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
product: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#

metaR ACCOAtn
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
product: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: acetyl-CoA transport, nuclear

metaM ppcoa c
type: Species
initial amount: NaN
is: CHEBI:57392
is: C00100
boundary condition: false
has only substance units: false
name: Propanoyl-CoA
is: HMDB01275
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR r0531
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.1.1.34
product: MODEL1310110056#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
reversible: true
modifier: MODEL1310110056#
is: SBO:0000176
fast: false
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
reactant: MODEL1310110056#

metaM dhbpt c
is: CHEBI:20680
initial concentration: 1.0
name: 6,7-dihydrobiopterin
constant: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00038

metaR r2089
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
reversible: true
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110056#
is: SBO:0000185

metaR PUNP3
name: purine-nucleoside phosphorylase (Guanosine)
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
product: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
is: SBO:0000176

metaR r0892
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
is: SBO:0000185
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.2.27
reversible: true
is described by: ECO:0000000
name: Facilitated diffusion
type: Reaction
fast: false
modifier: MODEL1310110056#
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_13c15e41_4ed0_41dd_ac77_4d9e8a797e36
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: AADAT
is encoded by: hsa:51166
type: Species
is: Q8N5Z0
boundary condition: true
is: SBO:0000252
constant: false

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaM oxa c
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:30623
name: oxalate(2-)
has only substance units: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: SBO:0000247
is: HMDB02329
initial amount: NaN

metaR GACPAILter
kinetic law: MODEL1310110056#
type: Reaction
name: glucosaminyl-acylphosphatidylinositol ER flippase
is described by: ECO:0000000
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
product: MODEL1310110056#
is: SBO:0000185
fast: false
reversible: false

metaM sbt D c
is: HMDB00247
constant: false
name: D-glucitol
initial concentration: 1.0
type: Species
is: CHEBI:17924
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
boundary condition: false
is: SBO:0000247

metaM 13 cis retn r
is: SBO:0000247
constant: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
is: D00348
name: 13-cis-retinoate
is: HMDB06219
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7847414
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false

metaR C50CPT1
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of isovalerylcarnitine
type: Reaction

metaM sl L e
boundary condition: false
name: (S)-3-sulfonatolactate(2-)
initial amount: NaN
is: CHEBI:61289
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C3H4O6S CHARGE: -2 INCHI: InChI=1S/C3H6O6S/c4-2(3(5)6)1-10(7,8)9/h2,4H,1H2,(H,5,6)(H,7,8,9)/p-2/t2-/m1/s1
constant: false

metaM ser L e
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
name: L-serine
constant: false
boundary condition: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: CHEBI:17115
is: HMDB00187
is: SBO:0000247

metaR PUNP4
name: purine-nucleoside phosphorylase (Deoxyguanosine)
modifier: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
product: MODEL1310110056#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000269
fast: false

metaM 3sala m
type: Species
initial concentration: 1.0
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: 3-sulfino-L-alanine (1-)
is: C00606
constant: false
is: CHEBI:61085
boundary condition: false

metaR RE3000M
kinetic law: MODEL1310110056#
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE3000
modifier: MODEL1310110056#
is described by: ECO:0000000

metaM gdpfuc g
boundary condition: false
is: HMDB01095
is: SBO:0000247
initial amount: NaN
is: CHEBI:57984
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
type: Species
name: GDP-L-fucose(2-)
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_dcbde5c5_e927_4653_b2b4_2d5cd684f7a8
is encoded by: hsa:501
initial amount: NaN
is: E7EPT3
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
is: SBO:0000252
name: ALDH7A1

http://identifiers.org/biomodels.db/MODEL1310110056#_6dde6323_225a_418a_acb5_2b012101ff9a
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8659
name: ALDH4A1
has only substance units: false

metaR CYTK14
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,UTP)
reversible: true
product: MODEL1310110056#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false

metaR r0789
kinetic law: MODEL1310110056#
is: SBO:0000176
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
fast: false
product: MODEL1310110056#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
modifier: MODEL1310110056#
reversible: true
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_a66362b4_694e_463e_8aac_de7617bd5546
initial amount: NaN
type: Species
is: Q9H310
is: SBO:0000252
constant: false
boundary condition: true
name: RHBG
initial concentration: NaN
is encoded by: hsa:57127
has only substance units: false

metaM dodecanac x
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C12H20O4 CHARGE: -2
name: Dodecanedioic acid
type: Species
is: HMDB00623
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_cfcd828d_9142_4e36_9088_b13e631a2176
type: Species
is: SBO:0000252
initial concentration: NaN
is: B3KVI7
initial amount: NaN
is encoded by: hsa:3712
constant: false
boundary condition: true
has only substance units: false
name: IVD

metaM ppi m
name: Diphosphate
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
constant: false
is: SBO:0000247
has only substance units: false
type: Species
is: C00013
is: CHEBI:33019
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110056#_2d9521de_e147_4efb_acba_45ec3981d954
is encoded by: hsa:84532
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
name: ACSS1
type: Species
is: Q9NUB1

metaR PUNP5
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
name: purine-nucleoside phosphorylase (Inosine)
type: Reaction
reactant: MODEL1310110056#
reversible: true
kinetic law: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000269

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaM lac D c
type: Species
name: (R)-lactate
is: SBO:0000247
is: CHEBI:16004
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
initial concentration: 1.0
has only substance units: false
is: HMDB01311
boundary condition: false
constant: false

metaR r0784
reactant: MODEL1310110056#
is: SBO:0000176
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: true
is described by: ECO:0000000
product: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
type: Reaction

metaR r2329
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110056#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false

metaR r1638
fast: false
modifier: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
reversible: true

metaR RE2999M
kinetic law: MODEL1310110056#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/5.3.3.8
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110056#
type: Reaction
is: SBO:0000176
reversible: true
is described by: ECO:0000000
name: RE2999

http://identifiers.org/biomodels.db/MODEL1310110056#_b452c465_7e96_430a_9faf_d842f03027de
is: P49247
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
name: RPIA
is encoded by: hsa:22934
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_8345f5bb_3ba3_408c_b5d6_8912f62d9cc3
is encoded by: hsa:2582
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: Q14376
boundary condition: true
type: Species
name: GALE

http://identifiers.org/biomodels.db/MODEL1310110056#_39ad702f_613f_43e1_81ff_9253289b86bb
initial amount: NaN
type: Species
initial concentration: NaN
name: HAS3
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:3038
is: Q96RV2

metaR r2197
reactant: MODEL1310110056#
modifier: MODEL1310110056#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
product: MODEL1310110056#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false

metaM oxa m
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:30623
boundary condition: false
name: oxalate(2-)
is: HMDB02329

http://identifiers.org/biomodels.db/MODEL1310110056#_4957fded_7613_4391_9ca4_fdeb865d109c
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:27430
has part: Q9NZL9
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000297
name: MAT2B:MAT2A
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_e7b0aef2_250b_44e2_bf7e_f5882de1b3c3
type: Species
initial concentration: NaN
is: SBO:0000252
name: NUDT12
initial amount: NaN
boundary condition: true
is: Q9BQG2
constant: false
is encoded by: hsa:83594
has only substance units: false

metaR r0783
modifier: MODEL1310110056#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
fast: false
kinetic law: MODEL1310110056#
reversible: true
reactant: MODEL1310110056#
is described by: ECO:0000000
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR PIPLC
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
type: Reaction
modifier: MODEL1310110056#
is described by: ECO:0000000
reversible: false
name: phosphatidylinositol phospholipase C
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.11
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000176
reactant: MODEL1310110056#

metaR r1639
reactant: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR URIK1
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.48
is described by: ECO:0000269
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
name: uridine kinase (ATP:Uridine)
is: SBO:0000176

metaR CHOLtg
kinetic law: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
reactant: MODEL1310110056#
type: Reaction
reversible: true
is: SBO:0000185
name: choline intracellular transport
is described by: ECO:0000000
product: MODEL1310110056#

metaR PPAm
product: MODEL1310110056#
type: Reaction
is: SBO:0000176
reversible: false
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.1
name: inorganic diphosphatase

metaR r0688
reversible: true
reactant: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
is: SBO:0000176
product: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110056#
is described by: ECO:0000000

metaR r2198
kinetic law: MODEL1310110056#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
product: MODEL1310110056#
fast: false
modifier: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
reactant: MODEL1310110056#
is: SBO:0000185

metaR DM dsT antigen g
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dsT antigen(g)
type: Reaction

metaM galside hs g
is: CHEBI:12947
constant: false
is: SBO:0000247
name: D-galactosyl-N-acylsphingosine
boundary condition: false
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR FAOXC164GC163m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

metaR FAOXC226C225m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

metaR RE0935E
fast: false
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
reversible: true
modifier: MODEL1310110056#
name: RE0935
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.17
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.1
type: Reaction

metaM ppa e
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17272
is: HMDB00237
type: Species
initial amount: NaN
boundary condition: false
name: propionate
has only substance units: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163

http://identifiers.org/biomodels.db/MODEL1310110056#_91e60c71_a48b_4342_b892_89c761181906
is encoded by: hsa:2222
name: FDFT1
type: Species
is: SBO:0000252
is: P37268
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_ef480ec6_0302_4def_b95a_6e3c79e61900
is encoded by: hsa:343
initial amount: NaN
is: O94778
name: AQP8
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false

metaR r2327
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
product: MODEL1310110056#
type: Reaction
is described by: ECO:0000000

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

metaM octdececrn c
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
constant: false
is: HMDB06351
notes: FORMULA: C25H47NO4 CHARGE: 0
has only substance units: false

metaR 3SPYRSPm
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
is described by: ECO:0000000
fast: false
is: SBO:0000176
kinetic law: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
product: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction

metaR BILIRUBtr
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110056#
type: Reaction
name: lipid, flip-flop intracellular transport
fast: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ

metaM gdpfuc c
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
constant: false
is: HMDB01095
is: SBO:0000247
is: CHEBI:57984
boundary condition: false
name: GDP-L-fucose(2-)

metaR PE HSter
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
reactant: MODEL1310110056#
fast: false
type: Reaction
kinetic law: MODEL1310110056#
name: phosphatidylethanolamine scramblase
is described by: ECO:0000000
reversible: true
product: MODEL1310110056#

metaR r0899
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110056#
is: SBO:0000185
product: MODEL1310110056#
reversible: true
name: Amino acid transporter ATB0+ Facilitated diffusion

http://identifiers.org/biomodels.db/MODEL1310110056#_402fbb0a_eff7_4843_8121_343eb966364d
is encoded by: hsa:219
initial amount: NaN
constant: false
is: SBO:0000252
is: P30837
name: ALDH1B1
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species

metaR G5SDym
product: MODEL1310110056#
name: glutamate-5-semialdehyde dehydrogenase (m)
modifier: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 1.2.1.41 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m TDV: name change from G5SDm
reversible: false
reactant: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.41
is: SBO:0000176

metaR C4STMO1r
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.14.13.72
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: false
fast: false
type: Reaction
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
is: SBO:0000176
is described by: ECO:0000000

metaR r2328
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
reversible: true

metaM sphings l
has only substance units: false
is: CHEBI:57756
boundary condition: false
is: HMDB00252
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
name: sphingosine(1+)

metaR ACSm
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.1
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 6.2.1.1 Confidence Level: 2 AUTHORS: PMID:11150295,PMID:4326157 NOTES:IF
modifier: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
fast: false
name: acetyl-CoA synthetase
reactant: MODEL1310110056#
is described by: ECO:0000304
is: SBO:0000176
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_f8fc786d_b4eb_45c2_88ad_700ad4ffc049
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: _AA081045_1_c
initial amount: NaN
constant: false
is encoded by: hsa:AA081045

http://identifiers.org/biomodels.db/MODEL1310110056#_a3598c6a_f88c_4b8b_a3b7_c477cc024775
is: SBO:0000252
has only substance units: false
boundary condition: true
name: ASPA
is: Q6FH48
is encoded by: hsa:443
type: Species
initial amount: NaN
initial concentration: NaN
constant: false

metaR r0686
fast: false
modifier: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000176
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
kinetic law: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is version of: http://identifiers.org/ec-code/2.3.2.2
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_718f74ba_f7ba_4f05_bad3_8a6ab382223e
is encoded by: hsa:5334
name: PLCL1
constant: false
is: Q15111
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_5818496b_b5ab_4e86_be94_2cfda838e25b
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1582
type: Species
name: CYP8B1
constant: false
boundary condition: true
is: Q9UNU6
is: SBO:0000252

metaR RE2269E
is version of: http://identifiers.org/ec-code/3.4.21.39
reversible: true
reactant: MODEL1310110056#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
name: RE2269
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_83475ad7_9d79_4bf4_8036_4f6170ad9e0a
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: Q99808
name: SLC29A1
is encoded by: hsa:2030

http://identifiers.org/biomodels.db/MODEL1310110056#_93564f86_95f0_486c_933e_962ed5dda7f5
is encoded by: hsa:1743
is encoded by: hsa:8050
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:4967
is: SBO:0000297
has part: P36957
is encoded by: hsa:1738
has part: Q02218
has part: O00330
name: DLD:DLST:OGDH:PDHX
boundary condition: true
initial amount: NaN
has part: P09622

http://identifiers.org/biomodels.db/MODEL1310110056#_1444bd61_44c2_48d9_9526_c7da688f81cc
boundary condition: true
initial concentration: NaN
is: P36959
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2766
type: Species
name: GMPR
initial amount: NaN

metaR FAOXC102C101x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:1)x
type: Reaction

metaR C181OHc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecenoylcarnitinec
type: Reaction

metaM ppa c
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: HMDB00237
name: propionate
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17272

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_2c367cea_17b0_47b1_adeb_fbf6dc92ce14
is: SBO:0000252
name: B3GNT1
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: O43505
constant: false
is encoded by: hsa:11041

http://identifiers.org/biomodels.db/MODEL1310110056#_e5ade55e_b0d7_4bfa_9237_07d457c6e608
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: DCK
initial amount: NaN
constant: false
is: P27707
initial concentration: NaN
is encoded by: hsa:1633

metaR r1634
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
type: Reaction

metaR RE1523M
fast: false
reversible: true
name: RE1523
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
product: MODEL1310110056#
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110056#
modifier: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR HPDCACRNCPT2
is described by: ECO:0000000
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
name: heptadecanoate transport into the mitochondria
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000176
reversible: false
type: Reaction
fast: false

metaR r0780
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
product: MODEL1310110056#
is: SBO:0000176
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
reactant: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110056#

metaR r2080
is described by: ECO:0000000
kinetic law: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110056#
fast: false
reactant: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r2193
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110056#
type: Reaction
fast: false
reactant: MODEL1310110056#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110056#
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_90acb19e_2591_437b_9f23_2a4522e89c55
initial amount: NaN
boundary condition: true
is encoded by: hsa:79646
is: Q9H999
constant: false
has only substance units: false
name: PANK3
initial concentration: NaN
type: Species
is: SBO:0000252

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

metaR r0539
is described by: ECO:0000000
modifier: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
reversible: true
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
is version of: http://identifiers.org/ec-code/1.1.1.34
type: Reaction

metaR CAATPS
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
fast: false
reversible: false
modifier: MODEL1310110056#
product: MODEL1310110056#
name: Ca ATPase
reactant: MODEL1310110056#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.3.8
kinetic law: MODEL1310110056#

metaR HPDCACRNCPT1
product: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (1375.2) or (1375.3) or (1374.1) or (126129.1) or (1375.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110056#
fast: false
modifier: MODEL1310110056#
is described by: ECO:0000000
name: carnitine fatty-acyl transferase

metaR r1635
reversible: true
is: SBO:0000185
modifier: MODEL1310110056#
is described by: ECO:0000000
fast: false
product: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR DM 4abut LPAREN n RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID: 16643338 NOTES:GABA in the intestine may aid in differentiation and proliferation of epithelial cells. GABA intake by oral administration has been shown to alleviate stress, worry and anxiety and additionally it can also improve human immunity (PMID: 16971751). However the PAT1 transporter located at the apical side of enterocytes have very low affinity for GABA. I have presumed that this oral GABA is used within intestine (unless administered at high very high pharmacological doses, GABA exit from the enterocytes may be mediated by other specifc transporters).
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for 4-Aminobutanoate(n)
type: Reaction

metaR MTHFD2
reversible: true
name: methylenetetrahydrofolate dehydrogenase (NAD)
is: SBO:0000176
type: Reaction
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.5.4.9
reactant: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000134

metaR GALASE8ly
fast: false
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110056#
reversible: false
is: SBO:0000176
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4

metaM l2fn2m2masn g
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C68H113N4O49X CHARGE: 0
is: SBO:0000247
has only substance units: false
is: CHEBI:28067
type: Species
initial amount: NaN

metaM sphs1p r
is: HMDB00277
boundary condition: false
type: Species
constant: false
has only substance units: false
name: sphingosine 1-phosphate(1-)
is: SBO:0000247
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
initial concentration: 1.0
is: CHEBI:60119
initial amount: NaN

metaR RE0577C
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
type: Reaction
name: RE0577
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: true
is described by: ECO:0000000

metaR r2081
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110056#
reversible: true
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_6d560585_fd98_4847_b0ec_05909d0c0c85
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:171425
type: Species
name: CLYBL
boundary condition: true

metaM q10h2 c
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: HMDB13111
name: Ubiquinol-10
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/6504740
has only substance units: false
constant: false
boundary condition: false

metaR NACHEX22ly
reactant: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
kinetic law: MODEL1310110056#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110056#

metaR C12DCACT
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of Dodecanedioic acid
type: Reaction

metaM acald e
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00990
is: CHEBI:15343
has only substance units: false
constant: false
name: acetaldehyde
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084

http://identifiers.org/biomodels.db/MODEL1310110056#_5f20d82b_14b8_42be_bd6e_686cac5637b2
is: G3V0F6
boundary condition: true
initial concentration: NaN
type: Species
name: DGKZ
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8525

metaR FAOXC184C164m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)m
type: Reaction

metaR r1636
modifier: MODEL1310110056#
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#
is: SBO:0000185
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_ca75fbd7_16b1_431e_9a82_022f2dee465d
is encoded by: hsa:51805
initial amount: NaN
name: COQ3
has only substance units: false
boundary condition: true
constant: false
is: Q9NZJ6
initial concentration: NaN
is: SBO:0000252
type: Species

metaM b2coa m
is: HMDB02009
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: crotonoyl-CoA(4-)
is: CHEBI:57332
type: Species
is: SBO:0000247
has only substance units: false

metaM subeac x
is: HMDB00893
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: suberic acid
boundary condition: false
notes: FORMULA: C8H12O4 CHARGE: -2
is: SBO:0000247

metaR r2082
modifier: MODEL1310110056#
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

metaR r2195
type: Reaction
kinetic law: MODEL1310110056#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_011698d2_c7f2_4bb2_b8ca_196965cb3881
is: P49327
type: Species
constant: false
is encoded by: hsa:2194
initial amount: NaN
has only substance units: false
name: FASN
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR RE2988X
name: RE2988
modifier: MODEL1310110056#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
reversible: true
product: MODEL1310110056#
is described by: ECO:0000000

metaR r0683
product: MODEL1310110056#
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110056#
type: Reaction
reversible: false
is described by: ECO:0000000
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
reactant: MODEL1310110056#
fast: false
modifier: MODEL1310110056#

metaM ppi e
is: CHEBI:33019
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
initial amount: NaN
initial concentration: 1.0
name: Diphosphate
is: SBO:0000247
boundary condition: false
is: C00013
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_0c132e9f_191b_401d_9d16_a74d758d432f
is: SBO:0000252
constant: false
name: MGAT2
has only substance units: false
is: Q10469
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4247
type: Species

metaR r1637
is described by: ECO:0000000
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110056#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#
reversible: true
modifier: MODEL1310110056#
is: SBO:0000185

metaM HC02206 c
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: prostaglandin C1(1-)
type: Species
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
is: CHEBI:57399
boundary condition: false

metaM mi14p c
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
is: HMDB00968
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:58282
initial amount: NaN
type: Species
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
boundary condition: false

metaR RE1534M
fast: false
reversible: true
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
reactant: MODEL1310110056#
product: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
name: RE1534
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110056#

metaR r0781
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
kinetic law: MODEL1310110056#
product: MODEL1310110056#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_6c96e6a8_5dfd_4ae5_a472_8c6501b7599d
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:788
boundary condition: true
is: O43772
constant: false
has only substance units: false
name: SLC25A20

metaR r2083
modifier: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false
reversible: true
product: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000000
reactant: MODEL1310110056#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM q10h2 e
has only substance units: false
is: HMDB13111
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
type: Species
is: http://identifiers.org/pubchem.compound/6504740
name: Ubiquinol-10
constant: false
initial amount: NaN

metaR r2196
is: SBO:0000185
type: Reaction
product: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR LEUGLYHYc
name: hydrolysis of leucylglycine
product: MODEL1310110056#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
reversible: true
kinetic law: MODEL1310110056#
is described by: ECO:0000134

metaM tststerone r
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: testosterone
type: Species
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: SBO:0000247
constant: false
is: HMDB00234
is: CHEBI:17347
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_fd86902b_81d3_44d2_a274_812bdf0b4c15
is: Q00266
name: MAT1A
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:4143
has only substance units: false
boundary condition: true

metaR r0680
is described by: ECO:0000000
product: MODEL1310110056#
fast: false
is: SBO:0000176
reactant: MODEL1310110056#
modifier: MODEL1310110056#
type: Reaction
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.137
reversible: true
kinetic law: MODEL1310110056#

metaM uri e
is: C00299
constant: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:16704
name: Uridine
initial concentration: 1.0
is: SBO:0000247
is: HMDB00296
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_c3acf311_c9b5_4bb2_8ea3_dd21caed4875
is encoded by: hsa:204
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
type: Species
name: AK2
boundary condition: true

metaR C12DCACOT
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of dodecanedioyl coa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_cd65fed5_20b6_4a06_96c5_88f314c6539c
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6309
constant: false
is: Q6GTM5
name: SC5DL
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR r2322
kinetic law: MODEL1310110056#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR HS4ly
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.10.1.1
type: Reaction
name: heparan-N-sulfatase, lysosomal
reactant: MODEL1310110056#
product: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000176
fast: false

metaM trdox c
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:18191
boundary condition: false
name: Oxidized thioredoxin
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
initial concentration: 1.0
is: C00343
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_b9940b68_ab0f_4fdb_afd5_dc5c3415a509
name: VNN3
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:55350
has only substance units: false
type: Species
initial amount: NaN

metaM clpnd e
is: SBO:0000247
type: Species
has only substance units: false
name: clupanodonic acid
is: CHEBI:53488
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial concentration: 1.0
is: HMDB06528
initial amount: NaN
boundary condition: false
constant: false

metaM nadh r
name: NADH(2-)
initial amount: NaN
initial concentration: 1.0
is: HMDB01487
type: Species
is: SBO:0000247
is: CHEBI:57945
constant: false
has only substance units: false
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
boundary condition: false

metaM dmnoncoa c
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
constant: false
initial concentration: 1.0
name: 4,8 dimethylnonanoyl-CoA
type: Species
is: HMDB11604
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR SERTHRNaEx
kinetic law: MODEL1310110056#
product: MODEL1310110056#
fast: false
modifier: MODEL1310110056#
type: Reaction
reversible: false
name: L-serine/L-threonine Na-dependent exchange (Ser-L in)
is: SBO:0000185
reactant: MODEL1310110056#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaR r0317
type: Reaction
fast: false
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
modifier: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
reactant: MODEL1310110056#
reversible: true
is version of: http://identifiers.org/ec-code/2.1.2.10
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_ef3f2c4f_fe3f_4316_97c6_10e7858a57bd
is encoded by: hsa:1738
initial concentration: NaN
name: DLD
initial amount: NaN
is: P09622
constant: false
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

metaR DOLDPP Uer
fast: false
reactant: MODEL1310110056#
is described by: ECO:0000000
product: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.43
modifier: MODEL1310110056#
reversible: false
name: Dolichyl-diphosphate phosphohydrolase, human (uterus)
type: Reaction
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
kinetic law: MODEL1310110056#

metaR FAOXC164C165m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

metaM 3sala c
is: CHEBI:61085
constant: false
boundary condition: false
type: Species
name: 3-Sulfino-L-alanine
is: C00606
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR r2321
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_0cfe5780_404a_4078_a951_be8f063898a8
name: SLC2A9
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:56606
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaM lnlnca c
is: CHEBI:32387
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
type: Species
has only substance units: false
is: HMDB01388
name: alpha-linolenate
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN

metaR BACCL
is described by: ECO:0000269
kinetic law: MODEL1310110056#
name: biotin-[acetyl-CoA-carboxylase] ligase
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.10
is: SBO:0000176
modifier: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
reactant: MODEL1310110056#
product: MODEL1310110056#
reversible: false

metaM nrvnccoa c
type: Species
boundary condition: false
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
is: SBO:0000247
constant: false
is: C16532
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: nervonyl coenzyme A

metaR FAOXC10C8x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_243c1631_d12c_41cd_8d32_9f574d55a58c
initial amount: NaN
is: SBO:0000252
name: DHFR
constant: false
type: Species
is encoded by: hsa:1719
is: P00374
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_ce0a6fd1_8675_4913_892b_f037b24a770b
is encoded by: hsa:54995
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: OXSM
type: Species
is: Q9NWU1
constant: false
has only substance units: false
is: SBO:0000252

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_fd983fb3_4537_43a8_a374_4fa2c6c9431a
initial amount: NaN
has only substance units: false
is: O95674
is encoded by: hsa:8760
name: CDS2
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true

metaM uri c
is: SBO:0000247
is: HMDB00296
is: C00299
has only substance units: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
constant: false
type: Species
is: CHEBI:16704
initial amount: NaN
name: Uridine
initial concentration: 1.0
boundary condition: false

metaR ELAIDCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine O-palmitoyltransferase
is: SBO:0000176
is described by: ECO:0000269
reversible: false
type: Reaction
kinetic law: MODEL1310110056#
fast: false
reactant: MODEL1310110056#
product: MODEL1310110056#
modifier: MODEL1310110056#

metaR r2320
product: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110056#
fast: false
type: Reaction

metaR NACHEXA14ly
type: Reaction
reactant: MODEL1310110056#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_abf902b3_92f9_4848_9e8c_44d049cdf7ad
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
name: NT5C
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:30833
constant: false
is: Q8TCD5

metaR GALASE4ly
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: false
product: MODEL1310110056#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
type: Reaction
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
is: SBO:0000176

metaR PROSTGF2t
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
fast: false
is described by: ECO:0000269
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
name: prostaglandin uniport
reactant: MODEL1310110056#
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110056#

metaM dece4coa x
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
name: 4-decenoylcoa
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: HMDB02145
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_44d55627_2088_4b26_af31_1134de4a0f3e
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q16878
name: CDO1
is encoded by: hsa:1036
type: Species

metaM ppcoa m
is: CHEBI:57392
initial concentration: 1.0
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
name: Propanoyl-CoA
is: HMDB01275
constant: false
is: C00100
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_5a387ab1_c92e_42ae_866f_be29939a7c00
is encoded by: hsa:AA676725
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
name: _AA676725_1_c
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_0693f36e_83b8_44e1_84d8_6c569aecd822
is encoded by: hsa:AI694761
boundary condition: true
initial amount: NaN
type: Species
constant: false
name: _AI694761_1_c
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR CHATn
name: Choline O-acetyltransferase
is described by: ECO:0000269
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
reactant: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.6
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_eae097e0_e828_48a7_b1fc_955935d63953
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:9963
constant: false
has only substance units: false
name: SLC23A1
is: Q9UHI7
initial amount: NaN
type: Species
boundary condition: true

metaM galside hs l
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: D-galactosyl-N-acylsphingosine
constant: false
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: CHEBI:12947
is: SBO:0000247
initial amount: NaN

metaM ksii core4 l
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01014
is: CHEBI:57255
initial amount: NaN
has only substance units: false
constant: false
name: keratan sulfate II (core 4-linked)
type: Species

metaR FAOXC17C15m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C17-->C15)m
type: Reaction

metaR ALCD21 L
name: alcohol dehydrogenase (L-1,2-propanediol)
is version of: http://identifiers.org/ec-code/1.1.99.24
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000304
product: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110056#
reversible: false
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
fast: false

metaR FAOXC16OHC16r
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

metaR ELAIDCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
modifier: MODEL1310110056#
is described by: ECO:0000000
fast: false
reversible: false
is: SBO:0000176
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110056#_5354e4bd_4c93_4c9d_8ab6_ec3a773ac3ea
initial amount: NaN
is: Q4KWH8
constant: false
is encoded by: hsa:23007
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: PLCH1
type: Species

metaR FAOXC123C102x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_cab2839b_437b_4306_b7fa_c794772d0e40
is: P15291
initial amount: NaN
name: B4GALT1
type: Species
is encoded by: hsa:2683
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN

metaM cgly c
is: SBO:0000247
is: HMDB00078
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
initial amount: NaN
constant: false
type: Species
boundary condition: false
has only substance units: false
name: L-cysteinylglycine
initial concentration: 1.0
is: CHEBI:4047

http://identifiers.org/biomodels.db/MODEL1310110056#_b815425e_b763_4065_83ad_d5d0830a7d04
name: GPX2
boundary condition: true
initial amount: NaN
is: P18283
constant: false
is encoded by: hsa:2877
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaR ECOAH12m
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
reversible: true
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
type: Reaction
product: MODEL1310110056#
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110056#
is: SBO:0000176
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
modifier: MODEL1310110056#

metaR ATP2ter
is described by: ECO:0000000
type: Reaction
name: AMP/ATP transporter, endoplasmic reticulum
reactant: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true

metaR PAIL HStn
reactant: MODEL1310110056#
name: phosphatidylinositol nuclear transport (diffusion)
product: MODEL1310110056#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110056#
fast: false
is described by: ECO:0000000

metaM 3octdectecoa m
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355
type: Species
constant: false
has only substance units: false
name: 3,6,9,12-octadecatetraenoylcoa
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_9780fe90_7993_46dc_88e7_12899c960831
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: NDUFB4
is encoded by: hsa:4710
initial concentration: NaN
type: Species
boundary condition: true
is: O95168

metaR r2326
product: MODEL1310110056#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110056#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR S6T9g
kinetic law: MODEL1310110056#
is described by: ECO:0000000
reactant: MODEL1310110056#
is: SBO:0000176
fast: false
product: MODEL1310110056#
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
modifier: MODEL1310110056#

metaM hdd2coa c
name: trans-Hexadec-2-enoyl-CoA
is: C05272
initial amount: NaN
initial concentration: 1.0
is: CHEBI:61526
is: SBO:0000247
has only substance units: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
boundary condition: false
is: HMDB03945
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_67067cf5_ad7c_4aee_8954_f75d1922bdd7
is: Q6FG42
initial concentration: NaN
type: Species
constant: false
name: NDUFA7
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4701
has only substance units: false

metaR FAOXC163Gm
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

metaM xoltriol m
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
is: HMDB01457
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
is: CHEBI:16496
initial amount: NaN
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaM HC01434 m
name: oxalatosuccinate(3-)
constant: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:58931
has only substance units: false
type: Species
initial amount: NaN

metaM crm hs l
initial amount: NaN
boundary condition: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
name: N-acylsphingosine
has only substance units: false
is: CHEBI:52639

http://identifiers.org/biomodels.db/MODEL1310110056#_eece4000_a7ce_43f7_b9a3_fb9cdb90144f
has only substance units: false
type: Species
boundary condition: true
is: O14880
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4259
name: MGST3

metaR OCDCAFATPc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecanoate (n-C18:0) by the enterocytes
type: Reaction

metaR G14T8g
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
type: Reaction
reversible: false
fast: false
product: MODEL1310110056#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110056#
is: SBO:0000176
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38

metaM no c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16480
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
initial amount: NaN
name: Nitric oxide
is: C00533
is: HMDB03378
constant: false

metaR EX cspg c LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan exchange
type: Reaction

metaR FAOXC12C12OHm
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->OHC12)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_9103bbd0_0d4f_44a5_814b_69432af24a5f
is encoded by: hsa:4723
initial concentration: NaN
type: Species
is: E5KNH5
is: SBO:0000252
initial amount: NaN
name: NDUFV1
constant: false
has only substance units: false
boundary condition: true

metaR r2325
reversible: true
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110056#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185

metaR r2324
fast: false
kinetic law: MODEL1310110056#
reversible: true
is: SBO:0000185
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110056#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction

metaR CHOLtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
fast: false
reversible: true
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
name: Choline transport, nuclear through pores
type: Reaction
is described by: ECO:0000000
product: MODEL1310110056#
is: SBO:0000185

metaR r0464
product: MODEL1310110056#
kinetic law: MODEL1310110056#
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
reactant: MODEL1310110056#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction

metaM glyb c
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
boundary condition: false
constant: false
type: Species
is: CHEBI:17750
initial amount: NaN
has only substance units: false
is: HMDB00043
name: glycine betaine
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_c9a674e5_8146_4402_8cd1_b086fafad670
boundary condition: true
is: Q96PL7
is encoded by: hsa:9154
name: SLC28A1
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR q10tm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110056#
reversible: true
name: transport of ubiquinone into mitochondria
reactant: MODEL1310110056#
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110056#

metaR CO2ter
name: CO2 endoplasmic reticular transport via diffusion
kinetic law: MODEL1310110056#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110056#
is: SBO:0000185
reactant: MODEL1310110056#
type: Reaction

metaM clpnd c
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: HMDB06528
constant: false
is: CHEBI:53488
is: SBO:0000247
has only substance units: false
name: clupanodonic acid

http://identifiers.org/biomodels.db/MODEL1310110056#_44da56a7_84d1_4f9b_8baf_2a7bedf0ab30
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2592
name: GALT
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: E7ET32
type: Species

metaM vacccrn m
has only substance units: false
name: Vaccenyl carnitine
type: Species
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB06351
constant: false
initial concentration: 1.0

metaR GMPR
name: GMP reductase
is version of: http://identifiers.org/ec-code/1.7.1.7
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
reversible: false
is: SBO:0000176
product: MODEL1310110056#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_4274fcaa_e9a4_4727_949f_7e83067f488b
initial amount: NaN
is: SBO:0000252
is: Q9BQL0
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
name: BCKDHB
is encoded by: hsa:594
constant: false

metaR r2323
is described by: ECO:0000000
kinetic law: MODEL1310110056#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110056#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_dfa58a0c_2fee_4874_8b52_5efca78e0848
initial concentration: NaN
name: PLD1
is: Q59EA4
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:5337
constant: false

metaR FAOXC121C10x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_1e039381_2049_4d13_8d4a_0e83df3f3565
is: Q5FWF5
boundary condition: true
is encoded by: hsa:114799
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: ESCO1
initial amount: NaN

metaM no e
type: Species
constant: false
is: SBO:0000247
name: Nitric oxide
initial concentration: 1.0
is: C00533
is: HMDB03378
is: CHEBI:16480
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
initial amount: NaN
has only substance units: false
boundary condition: false

metaM fum c
is: CHEBI:29806
initial amount: NaN
is: C00122
is: SBO:0000247
is: HMDB00134
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
has only substance units: false
type: Species
name: Fumarate

metaR CSNt
type: Reaction
name: cytosine transport via facilated diffusion
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110056#
fast: false
product: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000185
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_ff69b84d_14a2_4630_9653_00e5eb61d725
name: NDUFA10
initial amount: NaN
initial concentration: NaN
is: O95299
type: Species
is encoded by: hsa:4705
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false

metaR GLCAASE4ly
fast: false
modifier: MODEL1310110056#
is: SBO:0000176
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.31
is described by: ECO:0000000
name: beta-glucuronidase, lysosomal
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
reactant: MODEL1310110056#

metaR PHYCBOXL
is: SBO:0000176
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
fast: false
is described by: ECO:0000212
modifier: MODEL1310110056#
name: L-Phenylalanine carboxy-lyase
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/4.1.1.28
reactant: MODEL1310110056#
reversible: false
type: Reaction

metaR PROt4 2 r
modifier: MODEL1310110056#
reactant: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
reversible: true
name: Proline transport (sodium symport) (2:1)
product: MODEL1310110056#
is described by: ECO:0000006
is: SBO:0000185
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction

metaR PEPCK
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.32
notes: GENE_ASSOCIATION: (5105.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:17211624,PMID:17888579,PMID:17888580,PMID:8325643 NOTES:17888579 - kinetic characterization of human cytosolic form; 8325643 - homology to rat; 17211624 - immunohistochemistry for expression
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
fast: false
is: SBO:0000176
product: MODEL1310110056#
modifier: MODEL1310110056#
name: Phosphoenolpyruvate carboxykinase (GTP)
type: Reaction
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110056#_d0ed66b4_64fa_41ea_b797_4f1cbe4c9cdc
name: GSR
initial concentration: NaN
is: P00390
is: SBO:0000252
is encoded by: hsa:2936
initial amount: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false

metaM lac D e
has only substance units: false
name: (R)-lactate
constant: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
is: CHEBI:16004
is: HMDB01311
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR r1418
is described by: ECO:0000000
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reversible: true
kinetic law: MODEL1310110056#
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
reactant: MODEL1310110056#
is: SBO:0000176
type: Reaction
fast: false

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaR PUNP7
product: MODEL1310110056#
fast: false
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
type: Reaction
name: purine-nucleoside phosphorylase (Xanthosine)
reversible: true
reactant: MODEL1310110056#
is described by: ECO:0000269
kinetic law: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1

metaM chol c
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
boundary condition: false
is: HMDB00097
is: SBO:0000247
type: Species
name: Choline
is: C00114
initial concentration: 1.0
is: CHEBI:15354

metaR RBTt
fast: false
name: ribitol transport via passive diffusion
reactant: MODEL1310110056#
is described by: ECO:0000000
kinetic law: MODEL1310110056#
reversible: false
product: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_9c9708d1_ebfa_4ace_8a93_1f89363ff41f
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:6240
name: RRM1
is: P23921
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN

metaM prostge2 e
has only substance units: false
is: HMDB01220
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
initial concentration: 1.0
type: Species
name: prostaglandin E2(1-)
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:606564

metaM ppcoa x
is: HMDB01275
is: SBO:0000247
boundary condition: false
is: C00100
type: Species
name: Propanoyl-CoA
is: CHEBI:57392
initial concentration: 1.0
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
has only substance units: false
initial amount: NaN
constant: false

metaR FAOXC184C163x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:3)x
type: Reaction

metaR r0113
is: SBO:0000176
product: MODEL1310110056#
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
name: UDP-N-acetyl-D-glucosamine 2-epimerase Aminosugars metabolism EC:5.1.3.14
is version of: http://identifiers.org/ec-code/6.2.1.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 0 AUTHORS: PMID:10431835,PMID:15748884,PMID:3740419,PMID:4337336,PMID:5063602,PMID:5417402,PMID:9305887,PMID:9305888 NOTES:
reversible: false
reactant: MODEL1310110056#
type: Reaction
fast: false

metaM 7thf e
is: HMDB06559
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: heptaglutamyl folate (THF)
constant: false
is: SBO:0000247
notes: FORMULA: C49H57N13O24 CHARGE: -8
type: Species

metaR URCN
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.49
name: URCN
reactant: MODEL1310110056#
is: SBO:0000176
fast: false
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110056#
reversible: false
is described by: ECO:0000269
product: MODEL1310110056#

metaM CE5119 m
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
boundary condition: false
initial amount: NaN
name: trans-3-cis-8-tetradecadienoyl-CoA
has only substance units: false
initial concentration: 1.0
is: CHEBI:57923

metaM HC02210 e
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:34939
name: prostaglandin-d3
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1

metaR PUNP6
reactant: MODEL1310110056#
is described by: ECO:0000269
product: MODEL1310110056#
reversible: true
type: Reaction
fast: false
name: purine-nucleoside phosphorylase (Deoxyinosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#

metaR SR5ARr
is: SBO:0000176
fast: false
modifier: MODEL1310110056#
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
kinetic law: MODEL1310110056#
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.3.99.5
product: MODEL1310110056#
reversible: false

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaR HSD17B42x
is described by: ECO:0000269
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110056#
fast: false
reversible: false
modifier: MODEL1310110056#
name: hydroxysteroid (17-beta) dehydrogenase 4
type: Reaction
reactant: MODEL1310110056#

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_12989ca7_b0fa_4648_a200_86ca46fa809f
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
name: _AI697028_1_e
constant: false
is encoded by: hsa:AI697028
boundary condition: true

metaM sl L c
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:61289
name: (S)-3-sulfonatolactate(2-)
boundary condition: false
has only substance units: false
notes: FORMULA: C3H4O6S CHARGE: -2 INCHI: InChI=1S/C3H6O6S/c4-2(3(5)6)1-10(7,8)9/h2,4H,1H2,(H,5,6)(H,7,8,9)/p-2/t2-/m1/s1
is: SBO:0000247
type: Species

metaR r0310
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
fast: false
is described by: ECO:0000000
product: MODEL1310110056#
reversible: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
reactant: MODEL1310110056#
type: Reaction
is: SBO:0000176

metaR GLCt4
is: SBO:0000185
modifier: MODEL1310110056#
reversible: true
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
name: glucose transport via sodium symport
reactant: MODEL1310110056#
is described by: ECO:0000269
kinetic law: MODEL1310110056#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_28c501d5_7991_4743_9ee5_58d999471dca
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:64064
is: SBO:0000252
type: Species
name: OXCT2
is: Q9BYC2
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_9d53036e_ef4b_4031_9991_75496ebff453
boundary condition: true
name: CHAT
is: SBO:0000252
has only substance units: false
constant: false
is: D3DX95
initial amount: NaN
is encoded by: hsa:1103
initial concentration: NaN
type: Species

metaR VACCCPT2
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110056#
reversible: false
name: carnitine transferase
type: Reaction
modifier: MODEL1310110056#
fast: false
product: MODEL1310110056#
reactant: MODEL1310110056#

metaM trdox m
is: CHEBI:18191
constant: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: Oxidized thioredoxin

metaM nadh x
type: Species
is: HMDB01487
boundary condition: false
is: CHEBI:57945
name: Nicotinamide adenine dinucleotide - reduced
is: C00004
has only substance units: false
is: http://identifiers.org/pubchem.compound/3306
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR ALDD2xm
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
is described by: ECO:0000134
reactant: MODEL1310110056#
reversible: false
product: MODEL1310110056#
is: SBO:0000176
kinetic law: MODEL1310110056#
type: Reaction
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110056#
fast: false

metaM ksii core4 e
initial amount: NaN
is: HMDB00211
boundary condition: false
name: keratan sulfate II (core 4-linked)
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17268
constant: false
type: Species
notes: FORMULA: C89H142N7O72S3X CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110056#_1f4161f6_9cd0_458d_a87b_3211e097c697
boundary condition: true
is: SBO:0000252
name: CMAS
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:55907
type: Species
has only substance units: false
is: Q8NFW8

metaM prostge2 c
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:606564
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
initial amount: NaN
name: prostaglandin E2(1-)
is: HMDB01220
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_d123764c_5ea2_4978_bfe2_3fbc2a66ffcd
type: Species
is encoded by: hsa:1836
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: P50443
constant: false
has only substance units: false
name: SLC26A2

http://identifiers.org/biomodels.db/MODEL1310110056#_bd0b3047_b60b_4ef2_bc2e_e78d835b73c6
type: Species
constant: false
initial amount: NaN
name: NDUFB8
is encoded by: hsa:4714
is: SBO:0000252
is: O95169
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM dodecanac c
is: HMDB00623
constant: false
has only substance units: false
type: Species
notes: FORMULA: C12H20O4 CHARGE: -2
initial concentration: 1.0
initial amount: NaN
name: Dodecanedioic acid
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_571a7121_9670_43d2_8ad8_ac69aa60ae22
initial amount: NaN
is: Q16773
is: SBO:0000252
is encoded by: hsa:883
name: CCBL1
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_12402f58_a81d_4090_a551_848ff68383e7
name: NDUFC2
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: Q549M5
is encoded by: hsa:4718
initial concentration: NaN

metaM amet c
has only substance units: false
is: SBO:0000247
name: S-Adenosyl-L-methionine
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB01185
is: CHEBI:15414
is: C00019
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_d81ca192_b5b9_44d0_9caa_d70017fa20c1
is encoded by: hsa:197257
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: Q86WU2
name: LDHD

metaM chol e
initial amount: NaN
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
name: Choline
is: HMDB00097
is: C00114
has only substance units: false
is: CHEBI:15354
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_34026224_da44_4ed0_9a94_f3e9fc1c0466
boundary condition: true
has only substance units: false
name: FOLR3
is encoded by: hsa:2352
is: Q05C14
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR sink dd2coa LPAREN c RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: DD2COASINK
type: Reaction

metaM HC02210 c
is: SBO:0000247
constant: false
type: Species
name: prostaglandin-d3
initial amount: NaN
initial concentration: 1.0
is: CHEBI:34939
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
has only substance units: false

metaR URIt4
notes: GENE_ASSOCIATION: (9154.2) or (9154.1) or (64078.1) or (9153.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:SAB
product: MODEL1310110056#
reversible: false
reactant: MODEL1310110056#
fast: false
type: Reaction
is: SBO:0000185
name: uridine transport in via sodium symport
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000269

metaM ppi x
is: HMDB00250
name: Diphosphate
is: CHEBI:33019
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: C00013
constant: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_38f1c789_59d7_481f_a9a5_324e4a4917c1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9060
name: PAPSS2
is: SBO:0000252
constant: false
is: O95340
type: Species
has only substance units: false
boundary condition: true

metaM ksii core4 g
is: CHEBI:57255
type: Species
constant: false
is: HMDB01014
name: keratan sulfate II (core 4-linked)
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_5c0a7d3e_0ece_43cd_a026_acdddea98fd6
type: Species
initial concentration: NaN
initial amount: NaN
is: P28331
is encoded by: hsa:4719
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
name: NDUFS1

http://identifiers.org/biomodels.db/MODEL1310110056#_dd79ef7d_ea73_4940_af89_e480a9f13d87
is: P56556
initial concentration: NaN
constant: false
has only substance units: false
name: NDUFA6
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4700
boundary condition: true
type: Species

metaM C05965 e
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:57444
is: HMDB04243
name: 12(S)-HPETE(1-)
constant: false
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
initial amount: NaN

metaR RE1836X
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110056#
modifier: MODEL1310110056#
reversible: true
reactant: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.176
kinetic law: MODEL1310110056#
name: RE1836

metaR SEBCOAPET
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

metaM 4hbz m
notes: FORMULA: C7H5O3 CHARGE: -1 INCHI: InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)/p-1
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: 4-hydroxybenzoate
is: CHEBI:17879
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: HMDB00500

metaM chol g
has only substance units: false
constant: false
name: choline
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: HMDB00097
initial concentration: 1.0
is: CHEBI:15354
initial amount: NaN
type: Species

metaR DOLPGT2 Uer
reactant: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110056#
reversible: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is: SBO:0000176
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
is version of: http://identifiers.org/ec-code/2.4.1.265

metaR PIter
reactant: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
reversible: true
is: SBO:0000185
type: Reaction
name: phosphate transport, endoplasmic reticulum
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
kinetic law: MODEL1310110056#
fast: false

metaM glyc R c
is: CHEBI:16659
initial amount: NaN
name: D-glycerate
is: HMDB00139
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
boundary condition: false
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0

metaM lcts e
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
name: Lactose
is: C00243
has only substance units: false
is: CHEBI:17716
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
is: HMDB00186
constant: false
initial concentration: 1.0

metaR RE3566C
name: RE3566
kinetic law: MODEL1310110056#
is described by: ECO:0000000
reactant: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
fast: false
type: Reaction
product: MODEL1310110056#
is: SBO:0000176

metaM cgly e
is: CHEBI:4047
name: L-cysteinylglycine
is: HMDB00078
constant: false
type: Species
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaM HC02207 c
is: SBO:0000247
constant: false
name: prostaglandin-c2
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27555
boundary condition: false
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
type: Species

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR PROSTGE1t
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
fast: false
reversible: true
is described by: ECO:0000269
is: SBO:0000185
name: prostaglandin transport via bicarbonate countertransport
product: MODEL1310110056#
type: Reaction

metaR DCYTDn
type: Reaction
reversible: false
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
is: SBO:0000176
name: deoxycytidine deaminase, nuclear
kinetic law: MODEL1310110056#
is described by: ECO:0000254
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.5
product: MODEL1310110056#
modifier: MODEL1310110056#

metaR VACCCPT1
product: MODEL1310110056#
fast: false
modifier: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
name: carnitine O-palmitoyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000000
reversible: false

metaR RE1796R
type: Reaction
reactant: MODEL1310110056#
name: RE1796
modifier: MODEL1310110056#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110056#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
product: MODEL1310110056#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.145

metaR NMNATr
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: nicotinamide-nucleotide adenylyltransferase
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110056#
product: MODEL1310110056#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.1
modifier: MODEL1310110056#
type: Reaction
is: SBO:0000176

metaR GLNSERNaEx
reactant: MODEL1310110056#
modifier: MODEL1310110056#
name: L-serine/L-glutamine Na-dependent exchange (Gln-L in)
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110056#
product: MODEL1310110056#
fast: false
type: Reaction

metaR PMEVKc
name: phosphomevalonate kinase, cytosol
modifier: MODEL1310110056#
reactant: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added to substrate for elemental balancing.
is described by: ECO:0000134
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.2
kinetic law: MODEL1310110056#
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110056#_eef2ab1a_5100_484c_bba0_9df8bce2e292
is encoded by: hsa:2348
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: FOLR1
type: Species
boundary condition: true
initial amount: NaN
constant: false

MODEL1310110056
reaction: metaR GLYt7 211 r
reaction: metaR RE1709N
species: metaM hdca c
species: metaM ach c
reaction: metaR EX bhb LPAREN e RPAREN
species: metaM 2dr5p c
reaction: metaR r0840
reaction: metaR PI45PLC
reaction: metaR EX gluala LPAREN e RPAREN
reaction: metaR r1931
reaction: metaR ASNtm
reaction: metaR RE2541E
species: metaM dolmanp L c
reaction: metaR r0246
reaction: metaR LNLNCGt
reaction: metaR FACOAL1832
species: metaM cs b deg2 l
reaction: metaR r1876
species: metaM ca2 c
species: metaM xylu L c
reaction: metaR C30CPT1
species: metaM dcacoa x
species: metaM cholate c
species: metaM core4 g
species: metaM spmd e
reaction: metaR GLCNACPT U
reaction: metaR H2O2t
reaction: metaR NACHEXA14ly
species: metaM ppi m
reaction: metaR r2334
reaction: metaR LDH D
species: metaM dcmp c
reaction: metaR G14T4g
reaction: metaR BTNDe
reaction: metaR O2St
reaction: metaR RE0452M
reaction: metaR r1010
reaction: metaR r1912
species: metaM cs a deg4 l
reaction: metaR r1696
reaction: metaR S6T17g
species: metaM 3uib c
reaction: metaR FAOXC5C3x
species: metaM lneldc c
reaction: metaR INSTt4
species: metaM HC02210 e
reaction: metaR EX gua LPAREN e RPAREN
reaction: metaR ALAt2r
species: metaM leuktrB4 c
species: metaM elaid c
reaction: metaR r1602
reaction: metaR EX ahcys LPAREN e RPAREN
reaction: metaR C204CRNt
reaction: metaR EX 3hexdcrn
reaction: metaR M4MPDOL Uter
species: metaM phytcoa c
species: metaM hista e
reaction: metaR EX prostge1 LPAREN e RPAREN
reaction: metaR SPHMYLNtg
reaction: metaR EX c3dc
reaction: metaR B MANNASEly
reaction: metaR ADPCOACROT
species: metaM gam c
reaction: metaR EX arg L LPAREN e RPAREN
reaction: metaR DHPM2
species: metaM 3ddecdicoa m
species: metaM fuc L l
reaction: metaR C8DCc
reaction: metaR EX adrn LPAREN e RPAREN
reaction: metaR OCTDECCPT1
reaction: metaR RE1525M
species: metaM CE1926 e
species: metaM lpchol hs c
species: metaM ksii core4 pre8 g
species: metaM dcsptn1 c
reaction: metaR r2195
species: metaM g1p c
reaction: metaR TTDCPT1
species: metaM retinol e
reaction: metaR DNDPt11m

http://identifiers.org/biomodels.db/MODEL1310110056#_e913f620_ec37_49e1_a860_253dea3515f4
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:23236
initial amount: NaN
name: PLCB1
is: SBO:0000252
is: Q9NQ66
has only substance units: false
constant: false

metaR CHOLtu
kinetic law: MODEL1310110056#
type: Reaction
is: SBO:0000185
name: Choline uniport
reactant: MODEL1310110056#
is described by: ECO:0000269
modifier: MODEL1310110056#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
product: MODEL1310110056#

metaR BHBt
product: MODEL1310110056#
kinetic law: MODEL1310110056#
name: (R)-3-Hydroxybutanoate transport via H+ symport
reactant: MODEL1310110056#
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_5836cc77_d664_4280_857e_9ea1a1a92e00
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:HG2846-HT2983
has only substance units: false
boundary condition: true
name: _HG2846_HT2983_1_c
is: SBO:0000252
constant: false

metaR DOLP Uter
product: MODEL1310110056#
fast: false
type: Reaction
reversible: false
name: dolichol phosphate flippase (uterus)
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is described by: ECO:0000000

metaM pa hs c
is: CHEBI:57739
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
name: phosphatidate(2-)
is: SBO:0000247
type: Species

metaR FAOXC226C225x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)x
type: Reaction

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

metaM acnam c
initial concentration: 1.0
is: CHEBI:35418
is: SBO:0000247
name: N-acetylneuraminate
constant: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: HMDB00230

http://identifiers.org/biomodels.db/MODEL1310110056#_d4d504c4_4c03_4ee1_a9ad_ea26406396ad
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:206
name: _206_1_c

metaM fum m
constant: false
type: Species
initial concentration: 1.0
is: HMDB00134
boundary condition: false
is: C00122
has only substance units: false
is: SBO:0000247
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
name: Fumarate
is: CHEBI:29806
initial amount: NaN

metaR r0119
is: SBO:0000176
modifier: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.1.3.14
product: MODEL1310110056#
reversible: false
fast: false
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:

metaR NRVNCt
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110056#
name: fatty acid transport via diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
kinetic law: MODEL1310110056#
fast: false
product: MODEL1310110056#

metaR ALAGLYexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
is: SBO:0000185
product: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
name: L-alanine/glycine reversible exchange
reversible: true

metaR r0311
is described by: ECO:0000000
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
fast: false
product: MODEL1310110056#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
modifier: MODEL1310110056#

metaR FAOXC123C102m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)m
type: Reaction

metaM dolp L r
boundary condition: false
is: CHEBI:57683
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: dolichyl phosphate(2-)
initial concentration: 1.0

metaM sebacid x
has only substance units: false
is: HMDB00792
is: C08277
initial amount: NaN
name: sebacicacid
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H16O4 CHARGE: -2
type: Species
constant: false

metaR NACHEXA21ly
fast: false
name: beta-N-acetylhexosaminidase A, lysosomal
product: MODEL1310110056#
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reactant: MODEL1310110056#

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaM HC02207 e
name: prostaglandin-c2
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27555
boundary condition: false
type: Species
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955

metaR LACZe
name: b-galactosidase, extracellular
product: MODEL1310110056#
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase
is described by: ECO:0000134
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.108
is: SBO:0000176
reactant: MODEL1310110056#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_f696700d_9280_41f2_aaa5_edd4ba15824d
constant: false
is: P55084
initial concentration: NaN
is encoded by: hsa:3032
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
name: HADHB
is: SBO:0000252

metaM lnlnca e
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB01388
is: SBO:0000247
name: alpha-linolenate
type: Species
is: CHEBI:32387

metaM 3octdectecoa x
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
boundary condition: false
is: SBO:0000247
type: Species
constant: false
has only substance units: false
name: 3,6,9,12-octadecatetraenoylcoa
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355
initial amount: NaN

metaR AG13T6g
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
modifier: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000

metaR HSD3A2r
is version of: http://identifiers.org/ec-code/1.1.1.225
is described by: ECO:0000000
fast: false
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
kinetic law: MODEL1310110056#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
type: Reaction
reversible: true
reactant: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_e68b1872_c5c5_4df4_9159_49994a5b8b3d
is encoded by: hsa:7296
name: TXNRD1
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true

metaR COQ7m
type: Reaction
notes: GENE_ASSOCIATION: (10229.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.14.13.- IT
reversible: false
reactant: MODEL1310110056#
fast: false
is: SBO:0000176
name: Ubiquinone biosynthesis COQ7
product: MODEL1310110056#
is described by: ECO:0000269
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#

metaR r1620
is described by: ECO:0000000
product: MODEL1310110056#
fast: false
is: SBO:0000185
reactant: MODEL1310110056#
reversible: true
kinetic law: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_bc62149b_b264_4a55_959c_5811f5c38098
is encoded by: hsa:1629
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: DBT
type: Species
constant: false
is: P11182
is: SBO:0000252

metaR NACHEXA15ly
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
kinetic law: MODEL1310110056#
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110056#
fast: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000176

metaR RE3624M
is: SBO:0000176
reactant: MODEL1310110056#
name: RE3624
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
product: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR DHPM2
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 2 AUTHORS: NOTES:Also acts on dihydrothymine and hydantoin. Found not specific evidence in PubMed, but Dihydropyrimidinase is supposed to be in cytosol and catalyze this reaction. Old information
product: MODEL1310110056#
is: SBO:0000176
kinetic law: MODEL1310110056#
is described by: ECO:0000000
name: dihydropyrimidinase (dihydrothymine)
type: Reaction
reactant: MODEL1310110056#

metaM xylt e
is: HMDB02917
constant: false
has only substance units: false
name: xylitol
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: CHEBI:17151

metaM chsterol l
constant: false
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:16113
is: HMDB00067
is: SBO:0000247
name: cholesterol
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial amount: NaN

metaR MM7B2g
is: SBO:0000176
fast: false
reversible: false
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.113
product: MODEL1310110056#
reactant: MODEL1310110056#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_316f1350_0514_46aa_a23b_05f95deee3c7
is: O60760
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:27306
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
name: HPGDS

metaR C180CPT2
type: Reaction
name: carnitine O-stearoyl transferase
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
reactant: MODEL1310110056#
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000269
product: MODEL1310110056#

metaR C16DCc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexadecanedioylcarnitine
type: Reaction

metaR r1919
reversible: false
reactant: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
fast: false
product: MODEL1310110056#
is: SBO:0000185
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM leu L e
boundary condition: false
type: Species
is: HMDB00687
constant: false
initial amount: NaN
name: L-leucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
has only substance units: false
is: SBO:0000247
is: CHEBI:15603
initial concentration: 1.0

metaM CE2431 m
is: SBO:0000247
name: cis-deca-4-enoyl-CoA
has only substance units: false
constant: false
is: CHEBI:57795
type: Species
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_86e09aad_6c90_4c0b_8092_7e70738d6a2d
name: GLB1
has only substance units: false
type: Species
is: P16278
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2720
initial concentration: NaN

metaM pac c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
type: Species
is: CHEBI:18401
constant: false
is: HMDB00209
has only substance units: false
boundary condition: false
name: phenylacetate

metaR RE3347C
type: Reaction
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110056#
name: RE3347
reactant: MODEL1310110056#

metaR FACOAL1822
is described by: ECO:0000269
fast: false
type: Reaction
reactant: MODEL1310110056#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110056#

metaR CSBPASEly
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
fast: false
is: SBO:0000176
reactant: MODEL1310110056#
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
reversible: false
product: MODEL1310110056#
type: Reaction
is described by: ECO:0000000

metaM chol m
constant: false
is: CHEBI:15354
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
name: choline
is: HMDB00097
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110056#_3beb0787_77ba_47c2_9c0b_972f3097e852
constant: false
is: P27144
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:205
type: Species
initial amount: NaN
name: AK4

http://identifiers.org/biomodels.db/MODEL1310110056#_c240a573_5eb6_44dd_9156_ad46fcbb911c
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
name: ALDH3B1
type: Species
is encoded by: hsa:221
boundary condition: true
initial amount: NaN
is: P43353

http://identifiers.org/biomodels.db/MODEL1310110056#_f8c060f2_13a9_4166_a13d_ad46721c4338
initial amount: NaN
has only substance units: false
is: Q92535
boundary condition: true
initial concentration: NaN
name: PIGC
type: Species
is encoded by: hsa:5279
constant: false
is: SBO:0000252

metaR C180CPT1
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
modifier: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (1375.4) or (1375.2) or (126129.1) or (1375.1) or (1374.1) or (1375.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TV (see C160CRN)
is described by: ECO:0000269
name: production of stearoylcarnitine
product: MODEL1310110056#
is: SBO:0000176

metaM idour l
is: CHEBI:21338
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
name: L-iduronate
is: HMDB02704

metaR r1621
reactant: MODEL1310110056#
reversible: true
is described by: ECO:0000000
product: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM hdd2coa x
type: Species
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
name: (E)-hexadec-2-enoyl-CoA(4-)
is: HMDB03945
is: SBO:0000247
is: CHEBI:61526

metaM m2emgacpail hs r
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:24636
is: C00080
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
constant: false
boundary condition: false
type: Species
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)

metaM xylt c
type: Species
name: xylitol
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17151
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: HMDB02917

metaR FAOXTC142TC122m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C14:2-->C12:2)m
type: Reaction

metaR H6ET3er
product: MODEL1310110056#
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
type: Reaction
is: SBO:0000176
reversible: false
reactant: MODEL1310110056#
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
fast: false
kinetic law: MODEL1310110056#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.8.1

metaR C16DCe
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexadecanedioic acid mono-L-carnitine ester into extra cellular space
type: Reaction

metaM 3dphb m
initial amount: NaN
has only substance units: false
name: 3-Decaprenyl-4-hydroxybenzoate
type: Species
notes: FORMULA: C57H85O3 CHARGE: -1 INCHI: InChI=1/C57H86O3/c1-44(2)21-12-22-45(3)23-13-24-46(4)25-14-26-47(5)27-15-28-48(6)29-16-30-49(7)31-17-32-50(8)33-18-34-51(9)35-19-36-52(10)37-20-38-53(11)39-40-54-43-55(57(59)60)41-42-56(54)58/h21,23,25,27,29,31,33,35,37,39,41-43,58H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,59,60)/b45-23+,46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+
is: HMDB06251
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM tdchola c
name: taurochenodeoxycholate
is: HMDB00951
type: Species
constant: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
boundary condition: false
initial amount: NaN
is: CHEBI:9407
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110056#_fec1b781_6c9e_47af_bce0_a503de74cefb
name: PLA2G12A
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is: Q542Y6
is encoded by: hsa:81579
constant: false

metaR RE3001M
is described by: ECO:0000000
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.3.1.34
kinetic law: MODEL1310110056#
fast: false
type: Reaction
name: RE3001
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reversible: true
is: SBO:0000176
reactant: MODEL1310110056#
product: MODEL1310110056#

metaR URAt
name: uracil transport via facilated diffusion
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
reactant: MODEL1310110056#
reversible: true
product: MODEL1310110056#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#

metaR EX lneldc LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoelaidic acid exchange
type: Reaction

metaR r1917
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
reversible: false
is: SBO:0000185
product: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
fast: false

metaR r0779
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110056#
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_cae6ee20_560e_4014_a0c2_d0a94c27e9b0
boundary condition: true
name: LHPP
is: Q9H008
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:64077
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR DOLMANP Uter
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
reversible: false
fast: false
name: dolichol-phosphate mannose flippase (uterus)

metaM chsterol m
has only substance units: false
initial concentration: 1.0
name: cholesterol
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial amount: NaN
is: CHEBI:16113
is: HMDB00067
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_9735a3b7_4dd4_408e_adcc_ca369a4206d7
name: SULT1A1
initial concentration: NaN
is encoded by: hsa:6817
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true

metaM hs l
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:28815
name: heparan sulfate, free chain
type: Species
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
initial concentration: 1.0
boundary condition: false

metaR TYMSULT
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
is: SBO:0000176
fast: false
kinetic law: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110056#
name: Tyramine Sulfotransferase
is version of: http://identifiers.org/ec-code/2.8.2.1

metaM val L m
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00883
type: Species
initial concentration: 1.0
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: CHEBI:16414
initial amount: NaN
name: L-valine
boundary condition: false

metaR r1918
type: Reaction
product: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
modifier: MODEL1310110056#
is: SBO:0000185

metaR EX tethex3 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosahexaenoic acid, n-3 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_6a4d6c53_3fdc_45ef_b311_5307308b69d1
name: VNN3:VNN2:VNN1
type: Species
has part: O95498
is encoded by: hsa:8875
is encoded by: hsa:55350
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000297
constant: false

metaR FACOAL245 1
reversible: true
modifier: MODEL1310110056#
product: MODEL1310110056#
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
is: SBO:0000176
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110056#

metaM tdchola e
constant: false
is: HMDB00951
initial concentration: 1.0
name: taurochenodeoxycholate
initial amount: NaN
is: CHEBI:9407
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species

metaR r2079
fast: false
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110056#
is: SBO:0000185
product: MODEL1310110056#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_f4795874_ef6f_4849_92da_5ccf0194fc81
is: SBO:0000252
initial amount: NaN
is: Q16718
name: NDUFA5
is encoded by: hsa:4698
type: Species
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_54097d1d_ce79_4f39_8c2a_4bb9078c1697
initial amount: NaN
name: RRM2
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6241
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: P31350

metaR r0541
fast: false
modifier: MODEL1310110056#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
is described by: ECO:0000000
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
product: MODEL1310110056#
reversible: true

metaM udpg c
is: CHEBI:58367
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
has only substance units: false
type: Species
is: SBO:0000247
is: C00029
initial concentration: 1.0
name: UDPglucose
is: HMDB00286

metaR EBP1r
notes: GENE_ASSOCIATION: (10682.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 4 AUTHORS: PMID:10391219 NOTES:involved in lanosterol -> cholesterol pathway NJ
type: Reaction
reactant: MODEL1310110056#
product: MODEL1310110056#
reversible: false
name: 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase
fast: false
is: SBO:0000176
modifier: MODEL1310110056#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.3.5
kinetic law: MODEL1310110056#

metaM retinal cis 9 c
has only substance units: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
name: all-trans-retinal
is: HMDB01358
is: CHEBI:17898

metaM mescon m
type: Species
initial concentration: 1.0
is: CHEBI:36986
boundary condition: false
is: HMDB00749
constant: false
name: Mesaconate
has only substance units: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
is: SBO:0000247
initial amount: NaN

metaR 5ADTSTSTERONESte
reactant: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: sulfonated testosterone transport
reversible: true
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_9af8f534_645c_420a_9e14_9003d8e4c776
is: P05062
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:229
has only substance units: false
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: ALDOB

metaR FACOAL245 2
type: Reaction
product: MODEL1310110056#
fast: false
name: fatty-acid--CoA ligase
reactant: MODEL1310110056#
reversible: true
modifier: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_ff23bdc7_94d5_4c12_b2a3_99fc2443db98
type: Species
initial amount: NaN
is encoded by: hsa:728441
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
name: GGT2

metaR 2MB2COAc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 2-methylcrotonoyl-CoA into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_0e31d088_3953_4251_a0a9_03d196275b66
type: Species
is encoded by: hsa:3141
initial amount: NaN
initial concentration: NaN
name: HLCS
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
is: P50747

metaM forglu c
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: C00439
is: HMDB00854
has only substance units: false
is: CHEBI:18327
constant: false
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
type: Species
name: N-Formimidoyl-L-glutamate
initial concentration: 1.0

metaM 3oddcoa x
is: CHEBI:27868
is: SBO:0000247
name: 3-Oxododecanoyl-CoA
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB03937
constant: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
initial amount: NaN

metaM docohexcoa x
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
name: 2,4,7,10,13,16-docosahexenoylcoa
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790

metaM chol n
has only substance units: false
boundary condition: false
constant: false
name: choline
is: SBO:0000247
is: HMDB00097
is: CHEBI:15354
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114

metaM elaidcrn m
type: Species
boundary condition: false
is: HMDB06464
initial amount: NaN
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
name: Elaidic carnitine

metaR r0122
product: MODEL1310110056#
reactant: MODEL1310110056#
name: GTP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_9d34a5e8_fc5f_4c46_9a10_7d3d387eb6fc
boundary condition: true
is: B7Z4Y6
type: Species
initial concentration: NaN
has only substance units: false
name: ALPL
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:249

metaR LTC4CP
product: MODEL1310110056#
fast: false
reactant: MODEL1310110056#
is: SBO:0000176
reversible: true
type: Reaction
name: Leukotriene C4 carboxypeptidase
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
is described by: ECO:0000000

metaM 3hmbcoa m
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
is: SBO:0000247
is: HMDB01356
is: CHEBI:57312
constant: false
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
has only substance units: false
initial concentration: 1.0

metaR FAOXC15C13m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C15-->C13)m
type: Reaction

metaR GLUDxm
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110056#
fast: false
type: Reaction
name: glutamate dehydrogenase (NAD) (mitochondrial)
reactant: MODEL1310110056#
product: MODEL1310110056#
reversible: true
is version of: http://identifiers.org/ec-code/1.4.1.3
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110056#_1baa2002_79ab_440a_a753_79e5e7340be4
initial amount: NaN
type: Species
boundary condition: true
is: O00754
has only substance units: false
is: SBO:0000252
constant: false
name: MAN2B1
is encoded by: hsa:4125
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_35c93f59_604f_4113_846e_13314d93557c
is encoded by: hsa:1633
is: SBO:0000252
type: Species
name: DCK
is: P27707
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

metaR C4OHc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxybytyryl carnitinec
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_d614a4a9_8a2c_467f_9460_ee46ca0d96cc
is: O60762
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8813
name: DPM1

metaM c226crn c
name: cervonyl carnitine
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/127055
type: Species
has only substance units: false
is: HMDB06510
initial amount: NaN
constant: false
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
boundary condition: false

metaM CE4872 m
initial concentration: 1.0
is: HMDB00127
type: Species
boundary condition: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:15748
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872

metaR ETF
type: Reaction
reversible: false
reactant: MODEL1310110056#
fast: false
is described by: ECO:0000000
name: electron transfer flavoprotein
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
modifier: MODEL1310110056#
is: SBO:0000176
product: MODEL1310110056#
kinetic law: MODEL1310110056#

metaR GLUTCOAACBP
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of glutaryl-CoA(5-) from mitochondria into cytosol
type: Reaction

metaM dtdp e
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB01274
constant: false
initial concentration: 1.0
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
boundary condition: false
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363

metaM CE5101 m
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57795
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
boundary condition: false
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101

metaR r1853
is described by: ECO:0000000
modifier: MODEL1310110056#
fast: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
reversible: false
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_1d396cd6_e6d1_4f74_8416_9345dcff777e
initial concentration: NaN
initial amount: NaN
is: P36969
has only substance units: false
is encoded by: hsa:2879
name: GPX4
constant: false
is: SBO:0000252
type: Species
boundary condition: true

metaR ACONTm
type: Reaction
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
reactant: MODEL1310110056#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110056#
is described by: ECO:0000134
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/4.2.1.3
name: Aconitate hydratase
reversible: true
product: MODEL1310110056#

metaM thyox L e
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
name: L-thyroxine
initial amount: NaN
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: CHEBI:18332
is: SBO:0000247
is: HMDB00248
type: Species

metaR HPDCACRNt
name: heptadecanoate transport into the mitochondria
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000185
type: Reaction
reversible: false
product: MODEL1310110056#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ

metaR ALATHRNaEx
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: false
fast: false
reactant: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
modifier: MODEL1310110056#
name: L-alanine/L-threonine Na-dependent exchange (Ala-L in)
is described by: ECO:0000269

metaR GK1
fast: false
reversible: true
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.4.8
type: Reaction
modifier: MODEL1310110056#
product: MODEL1310110056#
name: guanylate kinase (GMP:ATP)

metaM chsterol c
name: cholesterol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
boundary condition: false
is: CHEBI:16113
initial concentration: 1.0
is: HMDB00067
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
constant: false

metaM HC01118 r
is: CHEBI:57310
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
constant: false
name: presqualene diphosphate(3-)
has only substance units: false
type: Species
initial concentration: 1.0

metaM CE2250 e
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: 3-oxodocosanoyl-CoA
is: CHEBI:52328
type: Species
constant: false
notes: FORMULA: C43H72N7O18P3S CHARGE: -4 INCHI: InChI=1S/C43H76N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-31(51)26-34(53)72-25-24-45-33(52)22-23-46-41(56)38(55)43(2,3)28-65-71(62,63)68-70(60,61)64-27-32-37(67-69(57,58)59)36(54)42(66-32)50-30-49-35-39(44)47-29-48-40(35)50/h29-30,32,36-38,42,54-55H,4-28H2,1-3H3,(H,45,52)(H,46,56)(H,60,61)(H,62,63)(H2,44,47,48)(H2,57,58,59)/t32-,36-,37-,38+,42-/m1/s1 EHMN_ABBREVIATION: CE2250
initial amount: NaN
has only substance units: false

metaR RE2998M
name: RE2998
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110056#
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#
is: SBO:0000176
reversible: false
product: MODEL1310110056#
is described by: ECO:0000000

metaR r1628
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110056#_0e57d715_5ea9_4ae8_8758_cb4fc842ede5
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:217
name: ALDH2
is: P05091
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species

metaR r2315
product: MODEL1310110056#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#

metaM tettet6coa x
boundary condition: false
type: Species
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
is: HMDB06516
is: C16171
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205481
name: tetracosatetraenoyl coenzyme A

metaM idour c
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
name: L-iduronate
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: HMDB02704
boundary condition: false
has only substance units: false
is: CHEBI:21338
initial concentration: 1.0

metaR r0774
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
fast: false
modifier: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
reactant: MODEL1310110056#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR FACOAL180i
modifier: MODEL1310110056#
type: Reaction
name: C180 fatty acid activation
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110056#
is described by: ECO:0000269
kinetic law: MODEL1310110056#
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases

metaR ESTRADIOLt
is described by: ECO:0000000
product: MODEL1310110056#
name: estradiol transport
fast: false
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#

metaM 2mbcoa m
type: Species
name: 2-methylbutanoyl-CoA(4-)
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB01041
is: SBO:0000247
is: CHEBI:57336
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
constant: false
initial concentration: 1.0

metaM c5dc c
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C12H21NO6 CHARGE: 0
type: Species
is: SBO:0000247
initial concentration: 1.0
name: glutaryl carnitine
is: HMDB13130

metaM ha e
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
type: Species
name: hyaluronan
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
has only substance units: false
is: CHEBI:16336

metaR r0545
is: SBO:0000176
product: MODEL1310110056#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110056#
is described by: ECO:0000000
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.6.1.5

metaR r0698
fast: false
modifier: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000176
kinetic law: MODEL1310110056#
type: Reaction
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
is version of: http://identifiers.org/ec-code/3.1.2.27
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
reversible: true
is described by: ECO:0000000

metaR r1912
type: Reaction
is: SBO:0000185
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000
modifier: MODEL1310110056#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_45f908f6_a34f_4f5f_9c68_45189fb1438f
is encoded by: hsa:4357
initial concentration: NaN
name: MPST
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: P25325
is: SBO:0000252

metaR r1629
is described by: ECO:0000000
kinetic law: MODEL1310110056#
fast: false
type: Reaction
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR TIGCRNe
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tiglyl carnitine into the extra cellular fluid
type: Reaction

metaR LEUKTRB4t
reactant: MODEL1310110056#
is described by: ECO:0000000
name: leukotriene B4 transport
kinetic law: MODEL1310110056#
reversible: true
product: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
fast: false

metaR r2316
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110056#
is described by: ECO:0000000
kinetic law: MODEL1310110056#
fast: false
reversible: true

metaR C226COAtx
type: Reaction
name: fatty acid intracellular transport
fast: false
reactant: MODEL1310110056#
is described by: ECO:0000000
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
kinetic law: MODEL1310110056#
reversible: true

metaM dtdp c
constant: false
is: CHEBI:58369
initial concentration: 1.0
is: C00363
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: SBO:0000247
is: HMDB01274
name: dTDP
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false

metaR KSIt
is: SBO:0000185
product: MODEL1310110056#
reactant: MODEL1310110056#
name: keratan sulfate I transport, golgi to extracellular
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false

metaR EX c81crn
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octenoyl carnitine
type: Reaction

metaR r0472
type: Reaction
reversible: true
reactant: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000176
kinetic law: MODEL1310110056#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

metaR H7 TAer
fast: false
name: H7' transamidase, endoplasmic reticulum
kinetic law: MODEL1310110056#
reversible: false
is: SBO:0000176
product: MODEL1310110056#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD

metaR FAOXC1811603m
type: Reaction
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
is described by: ECO:0000269
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
modifier: MODEL1310110056#
reactant: MODEL1310110056#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation fatty acid

metaM chsterol e
name: cholesterol
boundary condition: false
is: CHEBI:16113
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: HMDB00067
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaM ksi deg38 l
is: HMDB00143
notes: FORMULA: C54H91N3O41 CHARGE: 0
constant: false
name: keratan sulfate I, degradation product 38
type: Species
is: CHEBI:12936
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM crm hs g
constant: false
boundary condition: false
is: CHEBI:52639
type: Species
initial concentration: 1.0
name: N-acylsphingosine
initial amount: NaN
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_906a8df4_adb3_4627_9eb1_636fef36d33b
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:159963
initial amount: NaN
type: Species
has only substance units: false
name: SLC5A12
is: Q1EHB4

metaM thyox L c
is: HMDB00248
has only substance units: false
name: L-thyroxine
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
constant: false
initial amount: NaN
is: CHEBI:18332
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_3a897386_6d9e_498d_bcc3_5987d530d626
has part: P56181
has part: O95167
has part: O43181
has part: Q16795
has part: Q6IBC4
has part: Q9Y6M9
is encoded by: hsa:4707
is encoded by: hsa:4708
has part: P03905
has part: O43678
has part: F8VQS7
has part: O43674
has part: O95139
has part: O95168
is encoded by: hsa:4717
is encoded by: hsa:4696
has part: B7Z792
has part: Q16718
is encoded by: hsa:4541
is encoded by: hsa:55967
has part: Q7GXY9
has part: P28331
boundary condition: true
is encoded by: hsa:4537
is encoded by: hsa:4535
has part: P03915
has part: O75438
is encoded by: hsa:4704
is encoded by: hsa:4714
is encoded by: hsa:4712
has part: P19404
is encoded by: hsa:4695
has part: P56556
has part: O00217
is encoded by: hsa:4724
type: Species
constant: false
is encoded by: hsa:4722
is encoded by: hsa:4540
is encoded by: hsa:374291
has part: B1AM93
has part: Q13454
is encoded by: hsa:51079
is encoded by: hsa:7991
is encoded by: hsa:4731
has part: C9JT23
is encoded by: hsa:4701
is encoded by: hsa:4706
has part: O95169
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
has part: O95299
has only substance units: false
has part: Q7GXZ1
has part: O43677
is encoded by: hsa:4713
is encoded by: hsa:4729
is encoded by: hsa:4711
is encoded by: hsa:4694
has part: O75489
has part: Q7GXZ4
initial amount: NaN
is encoded by: hsa:4698
has part: Q6FG42
is encoded by: hsa:4716
initial concentration: NaN
is encoded by: hsa:4710
is encoded by: hsa:4709
has part: Q6IBB5
is: SBO:0000297
has part: Q6IBA0
has part: A8K761
is encoded by: hsa:126328
has part: O00483
has part: H7C5B8
is encoded by: hsa:4720
is encoded by: hsa:4719
has part: Q9P0J0
is encoded by: hsa:4539
has part: E5KNH5
has part: P17568

metaR r2317
kinetic law: MODEL1310110056#
fast: false
product: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110056#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r1626
is described by: ECO:0000000
product: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110056#
type: Reaction
reversible: true
modifier: MODEL1310110056#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_dabfe408_97f6_4494_9bb1_e2bc38f1e31b
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: EHHADH
boundary condition: true
type: Species
is encoded by: hsa:1962
is: Q9NY65

metaM idour e
is: HMDB02704
name: L-iduronate
is: CHEBI:21338
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial concentration: 1.0

metaR r0885
type: Reaction
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.3.1.38
fast: false
reversible: true
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7

metaR HDECEACBP
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecenoylcoa from mitochondria into the cytosol
type: Reaction

metaR r0475
reversible: true
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is: SBO:0000176
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
fast: false
type: Reaction
product: MODEL1310110056#

metaR r0547
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.1.4
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
reactant: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
name: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5
modifier: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_0d6a0223_5007_4d32_a71e_59cf8775f265
is: SBO:0000252
is encoded by: hsa:490
constant: false
boundary condition: true
is: P20020
name: ATP2B1
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

metaR PROD2m
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
fast: false
product: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.5.99.8
type: Reaction
name: Proline dehydrogenase (m)
reversible: false
reactant: MODEL1310110056#
is: SBO:0000176
modifier: MODEL1310110056#

metaM c5dc e
is: HMDB13130
initial amount: NaN
notes: FORMULA: C12H21NO6 CHARGE: 0
initial concentration: 1.0
name: glutaryl carnitine
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
constant: false

metaM ksii core2 deg9 l
constant: false
initial amount: NaN
name: keratan sulfate II (core 2-linked), degradation product 9
is: CHEBI:12936
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00143
notes: FORMULA: C30H50N3O20X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110056#_7783a7d2_2399_49a7_a6d5_d20aa6a4e7c6
is encoded by: hsa:4129
is: P27338
is: SBO:0000252
boundary condition: true
name: MAOB
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_acbc6fba_aa2d_4afa_928c_4308371f95d4
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:48
is: P21399
initial concentration: NaN
type: Species
name: ACO1
has only substance units: false

metaR r1627
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#

metaR r2318
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110056#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110056#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110056#

metaR HMGCOAtm
kinetic law: MODEL1310110056#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
fast: false
reactant: MODEL1310110056#
is: SBO:0000185
type: Reaction
product: MODEL1310110056#

metaM 3dpdhb me m
notes: FORMULA: C58H87O4 CHARGE: -1 INCHI: InChI=1S/C58H88O4/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58(60)61)43-56(62-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43,59H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3,(H,60,61)/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:50776
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_fc35adf4_96c8_49bd_a297_157b0a6216f7
boundary condition: true
initial amount: NaN
name: AGXT2L1
initial concentration: NaN
is encoded by: hsa:64850
is: Q8TBG4
is: SBO:0000252
has only substance units: false
type: Species
constant: false

metaR r0474
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reactant: MODEL1310110056#
product: MODEL1310110056#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110056#
type: Reaction

metaR r2319
reversible: true
kinetic law: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110056#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110056#_3c4d0b6a_5af5_4b4f_b33a_2c7dd1f75773
name: NDUFA9
is: SBO:0000252
is: Q16795
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:4704

metaR r1624
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
product: MODEL1310110056#
reactant: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_176eed47_4c4a_4df8_9856_aa24a3aaef6c
name: ALG3
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10195
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_06812459_ff96_4040_9e4b_d0ba009290cc
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1962
name: EHHADH:ACAA1:ACOX1
has part: Q9NY65
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_94f624ec_dd5a_4573_9e8d_a7469cb6cd4c
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:54344
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: Q86TM7
boundary condition: true
name: DPM3

metaR r1701
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110056#
name: Y+LAT2 Utilized transport
reversible: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110056#
reactant: MODEL1310110056#
product: MODEL1310110056#
fast: false

metaM hdd2coa m
boundary condition: false
is: SBO:0000247
has only substance units: false
is: C05272
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: HMDB03945
initial concentration: 1.0
name: trans-Hexadec-2-enoyl-CoA
is: CHEBI:61526

http://identifiers.org/biomodels.db/MODEL1310110056#_80adbd98_1228_44fa_ac16_94a269a6eb49
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
name: _642502_1_c
boundary condition: true
is encoded by: hsa:642502

http://identifiers.org/biomodels.db/MODEL1310110056#_237e71db_7b3c_48e6_a9d1_cf08c2e56de5
constant: false
initial concentration: NaN
is: SBO:0000252
name: HIBCH
is encoded by: hsa:26275
boundary condition: true
type: Species
is: Q6NVY1
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_6e14f8c3_d851_4331_9f7e_2edc0f3d6700
initial amount: NaN
is: P48651
boundary condition: true
initial concentration: NaN
is encoded by: hsa:9791
has only substance units: false
type: Species
constant: false
name: PTDSS1
is: SBO:0000252

metaM HC01434 c
initial amount: NaN
boundary condition: false
is: CHEBI:58931
initial concentration: 1.0
name: oxalatosuccinate(3-)
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
type: Species
is: SBO:0000247
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_3944be77_e128_4346_9999_ae42810ccad3
initial amount: NaN
name: SGPP1
is encoded by: hsa:81537
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is: Q9BX95
type: Species

metaR r1625
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110056#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
reversible: true
product: MODEL1310110056#
is: SBO:0000185

metaR ASNtN1
fast: false
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000185
name: Asparagine transport (Na, H coupled)
reactant: MODEL1310110056#
modifier: MODEL1310110056#
reversible: true

metaR r0549
is version of: http://identifiers.org/ec-code/6.1.1.17
product: MODEL1310110056#
reversible: true
kinetic law: MODEL1310110056#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
is version of: http://identifiers.org/ec-code/1.6.5.3
reactant: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
is version of: http://identifiers.org/ec-code/1.6.99.3
fast: false
modifier: MODEL1310110056#

metaM dcmp c
name: dCMP
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
initial amount: NaN
boundary condition: false
is: CHEBI:57566
is: C00239
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
is: HMDB01202
has only substance units: false

metaR THD1m
is: SBO:0000185
notes: GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES:TDV (2-6-2003)
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.6.1.2
name: NAD(P) transhydrogenase
product: MODEL1310110056#
reversible: true
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction

metaR BTNt4i
is: SBO:0000185
reactant: MODEL1310110056#
fast: false
modifier: MODEL1310110056#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110056#
reversible: false
name: Biotin uptake (antiport)
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_5470725c_d828_4bab_9091_564330ee71e4
initial amount: NaN
name: SLC5A5
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:6528
is: Q92911

metaM c226crn m
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB06510
constant: false
name: cervonyl carnitine
has only substance units: false
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
is: http://identifiers.org/pubchem.compound/127055
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110056#_0aadf62f_2b94_413b_9cf2_ac08a0766074
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6319
name: SCD
type: Species
boundary condition: true
is: O00767
has only substance units: false

metaM ksi pre6 g
is: SBO:0000247
boundary condition: false
notes: FORMULA: C107H174N7O80SX CHARGE: -2
has only substance units: false
is: C00130
constant: false
initial concentration: 1.0
type: Species
is: HMDB00175
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 6
initial amount: NaN

metaR r1622
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110056#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
modifier: MODEL1310110056#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110056#_a9ab4f6d_7177_4b82_882d_205088cde095
is: SBO:0000252
name: GPX4
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2879
is: P36969
constant: false
has only substance units: false
type: Species
boundary condition: true

metaR FAOXC184C163m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C18:4-->C16:3)m
type: Reaction

metaR ACOAD1fm
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
product: MODEL1310110056#
fast: false
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
reversible: false
type: Reaction
is described by: ECO:0000269
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial

metaM crm hs c
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
name: N-acylsphingosine
is: SBO:0000247
initial amount: NaN
is: CHEBI:52639
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195

metaM kynate c
initial amount: NaN
type: Species
is: HMDB00715
constant: false
initial concentration: 1.0
name: kynurenate
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
is: CHEBI:58454
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_504fcec2_8f8e_4815_b8ce_91421202d25c
initial amount: NaN
is encoded by: hsa:762
constant: false
initial concentration: NaN
type: Species
is: Q6FHI7
has only substance units: false
boundary condition: true
name: CA4
is: SBO:0000252

metaR FACOAL1821
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
kinetic law: MODEL1310110056#
is: SBO:0000176
reactant: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE1514C
fast: false
product: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000269
name: fatty-acid--CoA ligase

http://identifiers.org/biomodels.db/MODEL1310110056#_56a8b30c_e60b_47c6_b8dd_2ad68bf6b64a
is: SBO:0000252
is: P13196
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:211
name: ALAS1

metaR r1623
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_77eac4a6_bf41_4aab_b203_af7b76003505
is encoded by: hsa:278
initial amount: NaN
constant: false
is: P04745
has only substance units: false
name: AMY1C
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252

metaR ASPDxt
product: MODEL1310110056#
name: D-aspartate transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
is: SBO:0000185
type: Reaction
reactant: MODEL1310110056#
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110056#

metaM 4ppan c
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:10986
name: D-4'-Phosphopantothenate
initial concentration: 1.0
is: C03492
is: HMDB01016
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_4a8a9aa5_93a6_4247_bdf9_5d5eb119b85d
type: Species
initial concentration: NaN
boundary condition: true
constant: false
name: _AL050025_1_c
has only substance units: false
is encoded by: hsa:AL050025
is: SBO:0000252
initial amount: NaN

metaM 3octdeccrn c
name: 3-hydroxyoctadecanoyl carnitine
notes: FORMULA: C25H49NO5 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
is: HMDB13336
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
constant: false

metaM leu L c
is: HMDB00687
initial amount: NaN
is: CHEBI:15603
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
name: L-leucine
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM ksii core4 pre2 g
constant: false
is: C00130
notes: FORMULA: C47H76N4O33X CHARGE: -1
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00175
name: keratan sulfate II boisynthesis, precursor 2
is: CHEBI:58053

metaM cspg c e
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
is: SBO:0000247
is: HMDB00630
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:16040
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan

metaM gsn c
is: C00387
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
initial concentration: 1.0
constant: false
is: CHEBI:16750
initial amount: NaN
type: Species
is: HMDB00133
is: SBO:0000247
has only substance units: false
boundary condition: false
name: Guanosine

metaM dece4coa m
constant: false
name: 4-decenoylcoa
is: HMDB02145
type: Species
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110056#_96a45243_d57d_4b81_8cd2_5a025bdd73e9
name: GALK2
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2585
is: Q01415
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM doco13ac e
initial concentration: 1.0
is: SBO:0000247
is: HMDB02068
type: Species
name: docosenoic acid (C22:1)
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C22H41O2 CHARGE: -1
initial amount: NaN

metaR ALAGLNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
reactant: MODEL1310110056#
reversible: false
modifier: MODEL1310110056#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
name: L-alanine/L-glutamine Na-dependent exchange (Ala-L in)

http://identifiers.org/biomodels.db/MODEL1310110056#_ce6ed3d9_8d7f_4e67_a3b5_f28e94860a40
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: CPT1B
is encoded by: hsa:1375
type: Species
is: Q92523
constant: false

metaR O2tp
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110056#
is: SBO:0000185
name: O2 transport, peroxisomal
reactant: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
reversible: true

metaM 3octdeccrn e
has only substance units: false
name: 3-hydroxyoctadecanoyl carnitine
is: SBO:0000247
notes: FORMULA: C25H49NO5 CHARGE: 0
is: HMDB13336
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN

metaR AG13T18g
modifier: MODEL1310110056#
product: MODEL1310110056#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110056#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_3e62f394_5a28_43e4_b1d5_41fb98ee4c52
boundary condition: true
type: Species
initial concentration: NaN
is: E7EPT3
initial amount: NaN
is encoded by: hsa:501
is: SBO:0000252
has only substance units: false
name: ALDH7A1
constant: false

metaR FACOAL40im
type: Reaction
reactant: MODEL1310110056#
modifier: MODEL1310110056#
name: fatty-acid--CoA ligase (butanoate), mitochondrial
product: MODEL1310110056#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (116285.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: PMID:11470804,PMID:3297476 NOTES:JLR changed EC from 6.2.1.3 (long chain fatty-acyl CoA ligase) to 6.2.1.2 (butyrate-CoA ligase) - NCD
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.2
reversible: false
kinetic law: MODEL1310110056#

metaR 34HPPte
product: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110056#
reversible: true
name: Transport of 3-(4-hydroxyphenyl)pyruvate
reactant: MODEL1310110056#
fast: false
type: Reaction

metaM ile L c
type: Species
initial concentration: 1.0
is: HMDB00172
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
name: L-isoleucine
is: CHEBI:17191
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407

metaR STRDNCCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110056#
name: carnitine transferase
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
is: SBO:0000176
modifier: MODEL1310110056#
fast: false
reversible: false

metaR ECOAH1m
fast: false
reactant: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/4.2.1.18
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110056#
is described by: ECO:0000304
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
product: MODEL1310110056#
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110056#_84ddb3a7_17b0_4b2f_89eb_60f22d8f2205
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1345
is: P09669
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
name: COX6C
boundary condition: true

metaR ADRNt
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110056#
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction

metaM cs a deg4 l
is: HMDB00812
is: CHEBI:16953
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C31H49NO29S CHARGE: -2
boundary condition: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4

metaM ppi c
initial amount: NaN
boundary condition: false
is: C00013
is: CHEBI:0
constant: false
is: HMDB00250
has only substance units: false
initial concentration: 1.0
name: Diphosphate
type: Species
notes: FORMULA: HO7P2 CHARGE: -3
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_3800802e_3959_49e7_a6f9_ef233e49e254
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
name: RRM2B
is: Q7LG56
is encoded by: hsa:50484

metaR ASNSERNaEx
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000185
name: L-serine/L-asparagine Na-dependent exchange (Asn-L in)
product: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110056#
reversible: false

metaR PETHCT
is: SBO:0000176
reactant: MODEL1310110056#
reversible: false
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.7.14
fast: false
modifier: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000269
name: phosphoethanolamine cytidyltransferase
type: Reaction
notes: GENE_ASSOCIATION: (5833.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.14 Confidence Level: 4 AUTHORS: NOTES:NCD

metaM arab L c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0
is: CHEBI:30849
constant: false
has only substance units: false
is: HMDB00646
type: Species
is: SBO:0000247
name: L-arabinose

http://identifiers.org/biomodels.db/MODEL1310110056#_a5a9ff9c_67f1_45a8_9c97_00f207f380d3
has only substance units: false
initial amount: NaN
is encoded by: hsa:50814
is: SBO:0000252
constant: false
is: Q15738
boundary condition: true
initial concentration: NaN
name: NSDHL
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_1defb9ca_38f6_4331_90af_d6d5f6dc2e0f
type: Species
has only substance units: false
name: ALDH1A3
initial concentration: NaN
is encoded by: hsa:220
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
is: P47895

metaR STRDNCCPT1
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
modifier: MODEL1310110056#
name: carnitine O-palmitoyltransferase
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110056#

metaM sphings c
boundary condition: false
is: CHEBI:57756
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: HMDB00252
has only substance units: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
name: sphingosine(1+)

metaM 3oddcoa m
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
is: HMDB03937
name: 3-Oxododecanoyl-CoA
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:27868
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN

metaR PPAt
reactant: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
kinetic law: MODEL1310110056#
name: Propionate transport, diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
fast: false
is: SBO:0000185
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_c14dac29_69a1_4a40_93de_019778f57836
constant: false
type: Species
initial amount: NaN
name: _AA526438_1_c
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AA526438
has only substance units: false

metaR GALT
is version of: http://identifiers.org/ec-code/2.7.7.12
type: Reaction
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000000
reactant: MODEL1310110056#
name: galactose-1-phosphate uridylyltransferase

metaR URIt5le
is: SBO:0000185
kinetic law: MODEL1310110056#
reversible: false
fast: false
product: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
modifier: MODEL1310110056#
reactant: MODEL1310110056#
name: uridine transport in via sodium symport (1:2)
is described by: ECO:0000134

metaR EX tetpent6 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-6 exchange
type: Reaction

metaR r2310
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110056#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
product: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_0f07431f_d414_43f5_b584_1bef409b1e56
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: O75610
name: LEFTY1
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10637

http://identifiers.org/biomodels.db/MODEL1310110056#_4ce1e910_68d1_4024_88be_09643a015134
name: COX4I2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q96KJ9
is encoded by: hsa:84701
type: Species
constant: false
has only substance units: false

metaR DESAT22 2p
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
is: SBO:0000176
product: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false
reactant: MODEL1310110056#

metaM ile L e
type: Species
is: HMDB00172
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:17191
name: L-isoleucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407

http://identifiers.org/biomodels.db/MODEL1310110056#_e4349884_5bf0_463a_b6fc_9f46e99789f1
initial concentration: NaN
boundary condition: true
name: CPT1B
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:1375
is: SBO:0000252
constant: false
is: Q53FV7

http://identifiers.org/biomodels.db/MODEL1310110056#_271b1454_1b98_489a_8d38_e050c4b06c80
name: MAN2A1
is: SBO:0000252
type: Species
initial amount: NaN
is: Q16706
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4124
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_5933fc82_eac4_491f_ae10_343341309233
is: SBO:0000252
is: Q9NZL9
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:27430
has only substance units: false
name: MAT2B
boundary condition: true

metaR AHEXASEly
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110056#
modifier: MODEL1310110056#
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
fast: false
reversible: false
product: MODEL1310110056#
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_4937c231_51c7_4e5f_ac3c_a673b76d60ba
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
name: GAPDH
is encoded by: hsa:2597
type: Species
is: E7EUT4
initial amount: NaN

metaR 4ABUTtcn
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
name: transport of GABA
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: Jane D. Carver, W. Allan Walkera , The Journal of Nutritional Biochemistry, Volume 6, Issue 2, February 1995, Pages 58?72. NOTES:added during gap-filling, required for GABA role in cell proliferation.
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000134
reversible: false
product: MODEL1310110056#

metaM mi14p n
initial concentration: 1.0
is: HMDB00968
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: CHEBI:58282
has only substance units: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
is: SBO:0000247
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate

metaM arab L e
name: L-arabinose
boundary condition: false
is: CHEBI:30849
constant: false
initial concentration: 1.0
is: HMDB00646
notes: FORMULA: C5H10O5 CHARGE: 0
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN

metaR O2tm
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
fast: false
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110056#
name: O2 transport (diffusion)

http://identifiers.org/biomodels.db/MODEL1310110056#_d4a7d6be_f2c8_41b0_95e9_1baaa58fca85
type: Species
initial concentration: NaN
is: Q9UJS0
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: SLC25A13
is encoded by: hsa:10165
boundary condition: true

metaR COQ6m
notes: GENE_ASSOCIATION: (51004.1) or (51004.2) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.13.12.- IT
type: Reaction
name: Ubiquinone biosynthesis monooxgenase COQ6
fast: false
reactant: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110056#
reversible: false
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#

metaR GLCNACASE2ly
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
name: alpha-N-acetylglucosaminidase, lysosomal
product: MODEL1310110056#
reversible: false
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.50
reactant: MODEL1310110056#
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_1c1252b8_ef32_433e_95ab_c51ba53075c3
constant: false
has only substance units: false
name: AICDA
is encoded by: hsa:57379
boundary condition: true
type: Species
is: SBO:0000252
is: Q546Y9
initial amount: NaN
initial concentration: NaN

metaR RE2987X
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:10970790,PMID:7775433 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110056#
reversible: true
product: MODEL1310110056#
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
name: RE2987
is described by: ECO:0000000
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR HSD3A1r
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is described by: ECO:0000269
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.225
kinetic law: MODEL1310110056#
reversible: true
product: MODEL1310110056#
modifier: MODEL1310110056#

metaR PROSTGI2t
fast: false
product: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
kinetic law: MODEL1310110056#
reversible: true
name: Prostaglandin I2 transport
is described by: ECO:0000269
is: SBO:0000185

metaM ahcys m
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:16680
is: C00021
is: SBO:0000247
name: S-Adenosyl-L-homocysteine
type: Species
has only substance units: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: HMDB00939
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_86c0d0df_8919_47d2_a2dd_2b65e94bac0a
is encoded by: hsa:230
boundary condition: true
name: ALDOC
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: P09972

metaM f1a l
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: HMDB02917
constant: false
name: F1alpha
is: CHEBI:17151
is: SBO:0000247

metaR ADEt
modifier: MODEL1310110056#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
reactant: MODEL1310110056#
name: adenine reversible transport, cytosol
product: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
type: Reaction
reversible: true
is: SBO:0000185

metaR r2312
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: true
is: SBO:0000185
product: MODEL1310110056#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_a5a4c631_823d_4c1b_9cd6_b332a80a0285
initial amount: NaN
has only substance units: false
is encoded by: hsa:107
boundary condition: true
is: SBO:0000252
type: Species
is: Q08828
constant: false
initial concentration: NaN
name: ADCY1

metaM cspg c l
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
type: Species
is: HMDB02183
initial amount: NaN
is: CHEBI:36005
boundary condition: false
is: SBO:0000247
constant: false
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan

http://identifiers.org/biomodels.db/MODEL1310110056#_b3c8318c_7f41_49cc_be3b_72e03c7f02a0
boundary condition: true
initial concentration: NaN
constant: false
is: Q6UWQ5
initial amount: NaN
is: SBO:0000252
name: LYZL1
type: Species
is encoded by: hsa:84569
has only substance units: false

metaR EX sl L LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-sulfolactate exchange
type: Reaction

metaR FAOXC164x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)x
type: Reaction

metaR RE1342C
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
reversible: true
reactant: MODEL1310110056#
is: SBO:0000176
type: Reaction
name: RE1342
fast: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_09709083_9de6_4e69_a3e5_6e207841a1f2
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
name: OCRL
is encoded by: hsa:4952
is: Q01968
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_013b6686_3669_4406_a519_3c9bb0d475ac
is encoded by: hsa:AI285872
has only substance units: false
name: _AI285872_1_c
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_19c3372e_adf1_416a_875b_7a97f3d019a7
type: Species
boundary condition: true
initial amount: NaN
is: P53597
is: SBO:0000252
is encoded by: hsa:8802
has only substance units: false
constant: false
initial concentration: NaN
name: SUCLG1

http://identifiers.org/biomodels.db/MODEL1310110056#_76288a87_19de_4840_b8b0_6d429eeccd16
initial concentration: NaN
has only substance units: false
name: _AI620219_1_e
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:AI620219

metaM ptdca e
boundary condition: false
constant: false
is: SBO:0000247
name: pentadecanoate
initial concentration: 1.0
is: HMDB00826
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/22169126
has only substance units: false

metaR r2311
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110056#
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000185

metaR RTOTAL2t
is: SBO:0000185
name: RTOTAL2 transport
type: Reaction
reversible: true
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
product: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000

metaR G14T9g
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
modifier: MODEL1310110056#
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
type: Reaction
kinetic law: MODEL1310110056#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaM ha l
boundary condition: false
name: hyaluronan
is: CHEBI:16336
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
initial concentration: 1.0
type: Species
initial amount: NaN

metaR DHPR
reversible: false
fast: false
is described by: ECO:0000269
reactant: MODEL1310110056#
is: SBO:0000176
name: 6,7-dihydropteridine reductase
product: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.6.99.7 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.34

metaM dd5ecoa m
initial amount: NaN
type: Species
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
is: HMDB13028
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
name: 5-dodecenoylcoa
is: C01942

metaM xoldioloneh c
initial concentration: 1.0
constant: false
type: Species
is: HMDB06887
is: CHEBI:2288
initial amount: NaN
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
is: SBO:0000247
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
has only substance units: false
boundary condition: false

metaM acald m
is: HMDB00990
initial amount: NaN
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: SBO:0000247
has only substance units: false
is: CHEBI:15343
name: acetaldehyde
type: Species
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110056#_f431f4e8_4765_4d8a_81c2_b35044746970
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: GSTZ1
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2954
type: Species

metaM 4hglusa m
initial concentration: 1.0
is: SBO:0000247
name: L-4-hydroxyglutamic semialdehyde
is: HMDB06556
constant: false
boundary condition: false
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
is: CHEBI:27809
has only substance units: false
initial amount: NaN
type: Species

metaR r2314
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110056#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110056#

metaM dcacoa x
initial concentration: 1.0
type: Species
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
boundary condition: false
name: Decanoyl-CoA (n-C10:0CoA)
is: CHEBI:61430
is: HMDB06404
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C05274

metaR r1619
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110056#
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110056#
product: MODEL1310110056#

metaR ALAASNNaEx
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)
fast: false
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#

metaM ptdca c
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00826
boundary condition: false
name: pentadecanoate
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/22169126
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_6d2042bb_fd36_4595_b6af_015e01810b3d
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q9H0P0
is encoded by: hsa:51251
boundary condition: true
type: Species
name: NT5C3

metaR BILIRUBt2
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110056#
name: bilirubin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110056#
is described by: ECO:0000269
product: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#

metaR r2313
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110056#
is: SBO:0000185
kinetic law: MODEL1310110056#
product: MODEL1310110056#

metaR FACOAL181i
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
type: Reaction
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
name: C181 fatty acid activation
fast: false

metaR NOt
name: NO transport (diffusion)
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
fast: false
type: Reaction
product: MODEL1310110056#
reversible: true
reactant: MODEL1310110056#

metaR DHORTS
reactant: MODEL1310110056#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.1.3.2
is: SBO:0000176
name: dihydroorotase
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
modifier: MODEL1310110056#
product: MODEL1310110056#

metaR SIAASE4ly
name: sialidase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110056#
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110056#_f6806532_7741_4e37_8824_3a3bdaad5af4
type: Species
is encoded by: hsa:80271
is: Q96DU7
boundary condition: true
initial amount: NaN
name: ITPKC
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_f241d0b0_c2ef_424b_85bf_f37eeff560ce
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2592
type: Species
constant: false
is: B2RAT6
name: GALT
has only substance units: false

metaR r1618
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110056#
fast: false
modifier: MODEL1310110056#
reactant: MODEL1310110056#
product: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110056#_156f61be_1286_44cf_ab20_c20d7f18969f
name: DPAGT1
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1798
initial concentration: NaN
is: Q9H3H5
has only substance units: false

metaR SPODMm
type: Reaction
is described by: ECO:0000304
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
kinetic law: MODEL1310110056#
reversible: false
is version of: http://identifiers.org/ec-code/1.15.1.1
reactant: MODEL1310110056#
is: SBO:0000176
modifier: MODEL1310110056#
fast: false
name: superoxide dismutase

metaR Rtotaltl
name: fatty acid intracellular transport
product: MODEL1310110056#
reactant: MODEL1310110056#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - carnitine transporters not found, unknown mechanism intracellularly, however there must be a mechanism for FA transport NJ
is: SBO:0000185
kinetic law: MODEL1310110056#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110056#_68f70581_2375_447f_a842_80c37aaf038c
initial concentration: NaN
type: Species
name: SLC7A6
is: SBO:0000252
is encoded by: hsa:9057
is: Q92536
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false

metaR CYTDtm
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
name: cytidine facilated transport in mitochondria
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110056#

metaR r0999
type: Reaction
kinetic law: MODEL1310110056#
reversible: true
reactant: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110056#
name: Facilitated diffusion

metaR 4HBZFm
fast: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
type: Reaction
name: 4-hydroxybenzoate formation
product: MODEL1310110056#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110056#
is: SBO:0000176

metaR HPACtr
type: Reaction
name: hydroxyphenylacetate transport via diffusion
is described by: ECO:0000000
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
product: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
reversible: true
is: SBO:0000185

metaR RETH1e
reversible: false
kinetic law: MODEL1310110056#
type: Reaction
fast: false
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: retinyl ester hydrolase (9-cis), extracellular
is described by: ECO:0000000
reactant: MODEL1310110056#
is: SBO:0000176

metaM gln L e
is: CHEBI:18050
constant: false
type: Species
has only substance units: false
name: L-glutamine
is: HMDB00641
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
boundary condition: false
initial concentration: 1.0

metaM tetpent3 c
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
boundary condition: false
type: Species
is: HMDB06323
has only substance units: false
name: tetracosapentaenoic acid, n-3
initial amount: NaN

metaM leu L m
initial amount: NaN
constant: false
name: L-leucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
has only substance units: false
is: HMDB00687
initial concentration: 1.0
boundary condition: false
is: CHEBI:15603
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_54abf363_cd28_4153_bca0_4b183d4a72de
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5153
has only substance units: false
boundary condition: true
name: PDE1B
initial concentration: NaN
is: Q7Z364
type: Species
constant: false

metaM 3mox4hpac m
constant: false
is: HMDB05175
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
boundary condition: false
is: CHEBI:28111
initial concentration: 1.0
is: SBO:0000247

metaR ACNAMlt
reversible: true
name: N-acetylneuraminate transport into lysososme
type: Reaction
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
kinetic law: MODEL1310110056#
product: MODEL1310110056#
modifier: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000269
is: SBO:0000185
fast: false

metaR GALASE3ly
modifier: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110056#
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal

metaM tdec4ecoa m
initial concentration: 1.0
is: C08277
name: trans4decenoylcoa
constant: false
is: HMDB00792
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_99b15b7c_e21a_4b85_9a80_4c7342488735
name: C15orf33
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:196951
is: Q96M60

metaR GLYGLYCNc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of glycylycine for uptake
type: Reaction

metaR NRPPHRSULT
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110056#
is: SBO:0000176
modifier: MODEL1310110056#
name: Norepinephrine Sulfotransferase
type: Reaction
fast: false
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
is version of: http://identifiers.org/ec-code/2.8.2.1
reactant: MODEL1310110056#

metaM gchola x
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58235
notes: FORMULA: C26H43NO6 CHARGE: 0 INCHI: InChI=1S/C26H43NO6/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33)/p-1/t14-,15+,16-,17-,18+,19+,20-,21+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
is: HMDB00138
name: glycocholate
initial amount: NaN
has only substance units: false

metaR r2202
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000185
product: MODEL1310110056#
fast: false
reversible: true
modifier: MODEL1310110056#

metaM f1a g
initial amount: NaN
type: Species
boundary condition: false
is: HMDB02917
is: CHEBI:17151
notes: FORMULA: C22H37N2O15X CHARGE: 0
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: F1alpha

metaR EX CE5853 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-CEHC-glucuronide exchange
type: Reaction

metaM ksi deg3 l
is: SBO:0000247
initial amount: NaN
name: keratan sulfate I, degradation product 3
is: CHEBI:30825
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB00573
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_392263f9_59fa_487f_9187_890ce074e4f5
is encoded by: hsa:137872
is: SBO:0000252
name: ADHFE1
type: Species
initial concentration: NaN
constant: false
is: Q8IWW8
initial amount: NaN
boundary condition: true
has only substance units: false

metaM ocde9ecoa x
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
has only substance units: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355
constant: false
boundary condition: false
name: 9-octadecenoylcoa
initial amount: NaN
is: SBO:0000247

metaM gln L c
is: SBO:0000247
constant: false
is: HMDB00641
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: CHEBI:18050
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: L-glutamine
type: Species

metaR r1401
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.3.1.41
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.10.1
is: SBO:0000185
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/2.3.1.51
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.1.3
type: Reaction
reversible: false
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.35

http://identifiers.org/biomodels.db/MODEL1310110056#_4f28f92c_ff79_4616_895e_63ed39c07887
initial amount: NaN
type: Species
is encoded by: hsa:55229
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
name: PANK4
is: Q9NVE7

metaM 2mp2coa m
constant: false
name: 2-Methylprop-2-enoyl-CoA
has only substance units: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
is: HMDB01011
initial concentration: 1.0
is: CHEBI:27754

http://identifiers.org/biomodels.db/MODEL1310110056#_e630e515_9c5d_4fce_8b9b_b5bbefb0833c
name: DPYD
initial amount: NaN
initial concentration: NaN
constant: false
is: Q12882
type: Species
boundary condition: true
is encoded by: hsa:1806
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_6e5eb210_15ac_4773_b7cb_9a9a430367ab
initial amount: NaN
is encoded by: hsa:6120
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is: Q96AT9
initial concentration: NaN
type: Species
name: RPE

http://identifiers.org/biomodels.db/MODEL1310110056#_b8b3203a_f4b2_40ba_a924_03daf58cf025
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:5052
type: Species
initial amount: NaN
boundary condition: true
name: PRDX1
has only substance units: false

metaR r0321
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
is version of: http://identifiers.org/ec-code/6.3.5.2
type: Reaction
reversible: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000176
reactant: MODEL1310110056#
is described by: ECO:0000000
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
fast: false

metaR r2069
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110056#
is described by: ECO:0000000
modifier: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
is: SBO:0000185
reversible: false

metaM pre prot r
name: glycophosphatidylinositol (GPI)-anchored protein precursor
type: Species
notes: FORMULA: XY CHARGE: 0
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16038
has only substance units: false

metaR LEUKTRE4t
is described by: ECO:0000000
fast: false
product: MODEL1310110056#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110056#
name: leukotriene E4 transport
reactant: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaM Lkynr c
is: HMDB00684
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
initial amount: NaN
name: L-kynurenine
boundary condition: false
is: CHEBI:16946
has only substance units: false

metaR FAOXTC182TC162m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C18:2-->C16:2)m
type: Reaction

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaM dcmp n
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
name: dCMP(2-)
type: Species
is: CHEBI:57566
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB01202
is: SBO:0000247

metaR r0998
fast: false
reactant: MODEL1310110056#
is: SBO:0000185
type: Reaction
reversible: true
name: Facilitated diffusion
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
kinetic law: MODEL1310110056#
is described by: ECO:0000000

metaM CE5160 r
is: SBO:0000247
has only substance units: false
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
is: CHEBI:57923
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
name: 3-oxo-cis-9-octadecenoyl-CoA

metaR ENGASE2ly
fast: false
product: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110056#
is: SBO:0000176
reactant: MODEL1310110056#
name: endo-beta-N-acetylglucosaminidase, lysosomal
type: Reaction
is described by: ECO:0000000

metaM nm2masn g
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: C05884
notes: FORMULA: C42H70N3O30X CHARGE: 0
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_bd4b819b_428e_4720_95b2_6d0952bd23de
has only substance units: false
constant: false
initial concentration: NaN
is: P31213
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
name: SRD5A2
is encoded by: hsa:6716

http://identifiers.org/biomodels.db/MODEL1310110056#_d8126d79_6ade_4d99_9759_330820f3a397
is: SBO:0000252
has only substance units: false
constant: false
name: SGSH
is encoded by: hsa:6448
is: P51688
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species

metaR ALADGLYexR
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110056#
name: D-alanine/glycine reversible exchange
is described by: ECO:0000304
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#

metaM ksi pre3 g
is: CHEBI:58053
is: C00130
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C93H152N6O67X CHARGE: -1
type: Species
is: HMDB00175
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
name: keratan sulfate I biosynthesis, precursor 3

metaR AG13T7g
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
reactant: MODEL1310110056#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
reversible: false

metaM elaidcrn c
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
name: Elaidic carnitine
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: HMDB06464
is: SBO:0000247
has only substance units: false

metaM docohexcoa m
is: SBO:0000247
constant: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
name: 2,4,7,10,13,16-docosahexenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110056#_8cfcd3ff_ca2e_43f1_8536_42ff8e27e64f
is encoded by: hsa:92745
is: Q8WUX1
name: SLC38A5
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species

metaR RE3520E
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.11.1.9
kinetic law: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
name: RE3520
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110056#
reversible: true
fast: false

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaR S4TASE2ly
kinetic law: MODEL1310110056#
is: SBO:0000176
modifier: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
name: N-acetylgalactosamine-4-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
reversible: true
product: MODEL1310110056#
reactant: MODEL1310110056#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.12

metaR r0995
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
reversible: true
reactant: MODEL1310110056#
is described by: ECO:0000000
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is: SBO:0000185
product: MODEL1310110056#
fast: false

metaR Q10H2e
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
product: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
reversible: true
reactant: MODEL1310110056#
fast: false
name: transport of ubiquinol into lymph

metaM tetpent6 c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
type: Species
is: SBO:0000247
name: tetracosapentaenoic acid, n-6
is: HMDB06322
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-

metaM 3hexdtetcoa m
initial amount: NaN
name: 3,7,10,13-hexadecatetraenoylcoa
type: Species
is: SBO:0000247
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: HMDB02288
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0

metaR NADPtru
kinetic law: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
product: MODEL1310110056#
is: SBO:0000185
type: Reaction
fast: false
name: NADP transporter, endoplasmic reticulum
is described by: ECO:0000000
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_20e7150f_995b_4190_a898_32d17f429241
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:T83654
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: _T83654_1_m
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_fca4b272_0e91_4800_91e8_72dcfe67324d
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:6901
initial amount: NaN
is: SBO:0000252
name: TAZ
constant: false
is: Q16635

http://identifiers.org/biomodels.db/MODEL1310110056#_f192ddbb_a92b_4805_8f78_a21e111a57f3
is encoded by: hsa:4758
has part: Q99519
has part: P34059
is encoded by: hsa:2720
has part: P10619
has part: P16278
name: GALNS:GLB1:NEU1:CTSA
initial concentration: NaN
is encoded by: hsa:5476
type: Species
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:2588
boundary condition: true
constant: false
has only substance units: false

metaR FAOXC102C101m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaM 2octpencoa m
type: Species
boundary condition: false
name: 2,6,9,12,15-octadecapentenoylcoa
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5280355
constant: false
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_e40e7d2b_1486_4a7e_8b3a_48939f0cae9e
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:4726
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q6IBC4
type: Species
name: NDUFS6

http://identifiers.org/biomodels.db/MODEL1310110056#_7696603d_0d2a_424a_bdd4_99f3baf8d89a
initial amount: NaN
constant: false
name: PPAP2C
has only substance units: false
is: SBO:0000252
type: Species
is: E9PAY8
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8612

metaR r0993
is: SBO:0000185
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.2
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14716480,PMID:15209530,PMID:15297262 NOTES:
fast: false
kinetic law: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000

metaM ksi pre32 g
type: Species
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 32
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:28067

metaR r0129
fast: false
reversible: true
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.1.40
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110056#
product: MODEL1310110056#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4

metaR DGULND
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
name: dehydro-L-gulonate decarboxylase
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110056#
is: SBO:0000176
reactant: MODEL1310110056#
product: MODEL1310110056#

metaR GALU
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
type: Reaction
is described by: ECO:0000134
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
reactant: MODEL1310110056#
name: UTP-glucose-1-phosphate uridylyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.9
fast: false
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_a57a3d44_4d8a_4c2f_bde6_fc1ab0e000a5
initial concentration: NaN
type: Species
is encoded by: hsa:5336
name: PLCG2
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: P16885

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaM tetpent3 e
is: HMDB06323
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
type: Species
name: tetracosapentaenoic acid, n-3

metaM HC01407 m
name: (S)-Hydroxyhexanoyl-CoA
boundary condition: false
is: CHEBI:28276
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR r2201
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR NTP3e
modifier: MODEL1310110056#
is: SBO:0000176
kinetic law: MODEL1310110056#
name: nucleoside-triphosphatase (GTP)
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.6
is described by: ECO:0000269
product: MODEL1310110056#
fast: false
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_c5ceff48_5e83_4022_a7ce_8d4d0046f4e6
initial concentration: NaN
initial amount: NaN
is: O75874
name: IDH1
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3417
type: Species
constant: false
boundary condition: true

metaR GLCNACASE5ly
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.50
fast: false
type: Reaction
modifier: MODEL1310110056#
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000176
name: alpha-N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_d298c1e0_f6ca_44e6_97e6_e14fff88268b
initial concentration: NaN
is encoded by: hsa:4725
is: Q6IBA0
name: NDUFS5
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false

metaM dtdp m
constant: false
initial amount: NaN
is: C00363
is: SBO:0000247
is: HMDB01274
initial concentration: 1.0
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
has only substance units: false
boundary condition: false
type: Species
name: dTDP
is: CHEBI:58369

http://identifiers.org/biomodels.db/MODEL1310110056#_07c65438_3329_4c6a_80c7_0757fefc9a7a
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:6392
is: O14521
type: Species
is: SBO:0000252
boundary condition: true
name: SDHD

http://identifiers.org/biomodels.db/MODEL1310110056#_496cc7e4_45c8_45cc_b2f1_68e0ccabbf06
name: _AA664770_1_m
is encoded by: hsa:AA664770
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
type: Species

metaM tetpent6 e
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB06322
initial amount: NaN
name: tetracosapentaenoic acid, n-6
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-

http://identifiers.org/biomodels.db/MODEL1310110056#_daa9b36b_ff5d_4e6a_bc4d_d578c9160f44
initial amount: NaN
name: SLC16A1
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:6566
is: B4DKS0
is: SBO:0000252
constant: false
initial concentration: NaN

metaR HMGCOAtx
kinetic law: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
product: MODEL1310110056#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110056#

metaR r2200
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110056#
reactant: MODEL1310110056#
reversible: true
is: SBO:0000185
fast: false
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_d211ed62_5410_4d3e_9c15_67a9bd02cecb
type: Species
is: SBO:0000252
name: ALDH3B2
boundary condition: true
is: P48448
initial amount: NaN
has only substance units: false
is encoded by: hsa:222
initial concentration: NaN
constant: false

metaR r0994
name: Facilitated diffusion
type: Reaction
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110056#
is described by: ECO:0000000

metaM chsterol r
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:16113
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: HMDB00067
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: cholesterol

http://identifiers.org/biomodels.db/MODEL1310110056#_2b6e1c11_bf4e_4673_a40d_b856448f2229
initial amount: NaN
name: PLCG1
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5335
type: Species
is: Q9UFY1
has only substance units: false
is: SBO:0000252
constant: false

metaR HEX10
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
name: hexokinase (D-glucosamine:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.1
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.1.2
product: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: false
is described by: ECO:0000212

http://identifiers.org/biomodels.db/MODEL1310110056#_9744b0b7_d96c_47e4_b7fb_3793bc240f01
is: Q8N3T1
name: GALNTL2
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:117248
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_9b57049c_6f91_4124_b7af_25a0b10597a0
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
name: ACAA1
is: Q96CA6
is encoded by: hsa:30
initial amount: NaN
type: Species
is: SBO:0000252

metaR CYTK3
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000269
type: Reaction
product: MODEL1310110056#
reversible: true
name: cytidylate kinase (CMP)(GTP)
fast: false

metaR r1374
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
name: EC:3.2.1.14
reactant: MODEL1310110056#
reversible: false
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110056#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_1c49f64d_73c4_4faa_8fd6_97daaa99569f
is encoded by: hsa:2581
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
is: P54803
initial concentration: NaN
boundary condition: true
name: GALC

metaR G14T14g
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
kinetic law: MODEL1310110056#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
type: Reaction
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaR CYTK2
reactant: MODEL1310110056#
modifier: MODEL1310110056#
is: SBO:0000176
kinetic law: MODEL1310110056#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110056#
reversible: true
name: cytidylate kinase (dCMP)
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269

metaR r1546
reversible: true
is: SBO:0000185
reactant: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
is described by: ECO:0000000
fast: false

metaR PHCHGSm
kinetic law: MODEL1310110056#
is: SBO:0000176
reactant: MODEL1310110056#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
is described by: ECO:0000000
fast: false
product: MODEL1310110056#

metaM orot c
is: C00295
type: Species
constant: false
is: HMDB00226
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
name: Orotate
initial concentration: 1.0
is: CHEBI:30839
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295

http://identifiers.org/biomodels.db/MODEL1310110056#_908f6425_856e_47ed_9df7_b0e09d3f1e55
is: Q8NB10
constant: false
initial concentration: NaN
name: PDE1C
is encoded by: hsa:5137
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaR r1659
modifier: MODEL1310110056#
is: SBO:0000185
reactant: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#
reversible: true
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM thf m
type: Species
constant: false
is: HMDB01846
is: SBO:0000247
initial concentration: 1.0
name: 5,6,7,8-Tetrahydrofolate
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:57453
is: C00101
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101

metaR r0021
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
product: MODEL1310110056#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
reactant: MODEL1310110056#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.6.1.5

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaR SEBCOACROT
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

metaR CYTK4
is: SBO:0000176
product: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
kinetic law: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
reversible: true
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.4.3
name: cytidylate kinase (dCMP)(GTP)
is described by: ECO:0000269

metaR FAOXC2442246x
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110056#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c24:4,n-6 -> c22:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
is: SBO:0000176

metaM ksi pre24 g
boundary condition: false
initial amount: NaN
is: C00130
is: SBO:0000247
is: HMDB00175
constant: false
type: Species
name: keratan sulfate I biosynthesis, precursor 24
initial concentration: 1.0
has only substance units: false
is: CHEBI:58053
notes: FORMULA: C191H306N13O158S7X CHARGE: -8

metaM ksii core2 deg2 l
name: keratan sulfate II (core 2-linked), degradation product 2
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
has only substance units: false
is: HMDB00143
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:12936

metaR EX tdcrn
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for myristoyl carnitine
type: Reaction

metaR EX 3bcrn
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy butyryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_c0d76dec_7208_46ca_8091_bd6373ee1b6e
type: Species
is: P28332
name: ADH6
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:130
boundary condition: true
constant: false
initial amount: NaN

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaR r1658
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110056#

metaR r0022
is described by: ECO:0000000
modifier: MODEL1310110056#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.8.1.7
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
fast: false
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
reactant: MODEL1310110056#
reversible: true

metaR CYTK5
reactant: MODEL1310110056#
is: SBO:0000176
name: cytidylate kinase (dCMP)
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110056#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110056#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM pmtcrn c
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
boundary condition: false
is: SBO:0000247
is: CHEBI:17490
type: Species
initial amount: NaN
name: L-palmitoylcarnitine
is: HMDB00222

metaM dolglcp U c
initial concentration: 1.0
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
constant: false
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:15812
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_c40c8bd5_f84e_48a7_bade_ff6eeaae9064
has only substance units: false
name: LDHAL6B
initial amount: NaN
constant: false
is: Q9BYZ2
type: Species
is: SBO:0000252
is encoded by: hsa:92483
initial concentration: NaN
boundary condition: true

metaM dlnlcgcoa r
boundary condition: false
is: CHEBI:27979
is: C03595
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
name: dihomo-gamma-linolenyl coenzyme A
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false

metaM hexdtrcoa m
initial amount: NaN
constant: false
name: 7,10,13-hexadecatrienoylcoa
type: Species
is: HMDB02288
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR ELAIDCRNt
reversible: false
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
kinetic law: MODEL1310110056#
product: MODEL1310110056#
name: transport into the mitochondria (carnitine)
is described by: ECO:0000000
reactant: MODEL1310110056#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_8f4ab3ff_d6a9_4fe0_9c43_dcb9a308da28
has part: Q9P2X0
constant: false
is encoded by: hsa:54344
initial amount: NaN
initial concentration: NaN
name: DPM3:DPM1:DPM2
is: SBO:0000297
boundary condition: true
is encoded by: hsa:8818
has only substance units: false
type: Species

metaR CYTK1n
fast: false
is described by: ECO:0000269
product: MODEL1310110056#
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is: SBO:0000176
name: cytidylate kinase (CMP),nuclear
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM nadp r
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: C00006
initial amount: NaN
boundary condition: false
is: CHEBI:58349
is: SBO:0000247
initial concentration: 1.0
is: HMDB00217
name: Nicotinamide adenine dinucleotide phosphate
has only substance units: false
type: Species
constant: false

metaR r1548
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110056#
is: SBO:0000185
reactant: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110056#

metaR HTDCRNe
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-tetradecanoyl carnitine into extra cellular space
type: Reaction

metaM 3pg m
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
is: SBO:0000247
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
initial amount: NaN
has only substance units: false
is: HMDB00807
is: CHEBI:58272

metaR CYTK6
product: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
reactant: MODEL1310110056#
name: cytidylate kinase (CMP,CTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110056#
reversible: true
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110056#

metaR GALASE14ly
product: MODEL1310110056#
type: Reaction
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#

metaR r0879
is described by: ECO:0000000
product: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
fast: false
kinetic law: MODEL1310110056#
type: Reaction
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
reactant: MODEL1310110056#
reversible: false

metaM biocyt m
is: http://identifiers.org/pubchem.compound/7886
has only substance units: false
name: Biocytin
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
initial concentration: 1.0
is: HMDB03134
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: C05552
is: SBO:0000247

metaR C162ACBP
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxy trans7,10-hexadecadienoylcoa from mitochondria into cytosol
type: Reaction

metaR r1547
reversible: true
kinetic law: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_c581685f_3525_4fdb_bd7c_b900b2361cfa
is encoded by: hsa:1719
is: SBO:0000252
is: P00374
name: DHFR
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_468a1fc2_48f8_4f9a_94bf_8808fbf2fc6f
type: Species
is encoded by: hsa:51227
constant: false
name: PIGP
boundary condition: true
is: P57054
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_9a9e3985_a266_4f6c_b5b1_1e76e5d4a01f
is encoded by: hsa:250
name: ALPP
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P05187
initial amount: NaN
type: Species
constant: false
is: SBO:0000252

metaR CYTK7
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,UTP)
is: SBO:0000176
fast: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reversible: true
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110056#
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_b2c8b978_1ae7_4c35_bc16_32056000c1ce
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P49619
name: DGKG
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1608
type: Species

metaR GLYtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
kinetic law: MODEL1310110056#
product: MODEL1310110056#
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110056#
name: glycine passive transport to peroxisome
is described by: ECO:0000000
type: Reaction

metaR FAOXC18480m
modifier: MODEL1310110056#
name: Beta oxidation of fatty acid
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
reactant: MODEL1310110056#
is described by: ECO:0000000
type: Reaction
fast: false

metaR THFtm
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

metaR 4NPHSFte
is described by: ECO:0000000
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
name: xenobiotic transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat

metaM hdd2crn c
initial amount: NaN
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
type: Species
initial concentration: 1.0
name: trans-Hexadec-2-enoyl carnitine
constant: false
boundary condition: false
is: HMDB06317
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_e4184979_a0db_415a_b587_d32b69d116e3
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is encoded by: hsa:223
initial amount: NaN
is: P49189
boundary condition: true
name: ALDH9A1
initial concentration: NaN

metaM memgacpail hs r
is: SBO:0000247
constant: false
is: CHEBI:15809
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
initial amount: NaN

metaM dhdascb c
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
is: HMDB01264
boundary condition: false
initial amount: NaN
name: dehydroascorbide(1-)
is: CHEBI:58070
is: SBO:0000247
type: Species

metaR CYTK8
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
name: cytidylate kinase (CMP,dATP)
fast: false
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000176

metaR FAOXC163GC142m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaM tdcoa m
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
name: Tetradecanoyl-CoA (n-C14:0CoA)
type: Species
is: CHEBI:57385
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
is: C02593
is: HMDB01521

http://identifiers.org/biomodels.db/MODEL1310110056#_796f9377_4fe0_4e57_a6b9_39f4235e4281
type: Species
constant: false
name: TM7SF2
initial amount: NaN
is: O76062
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:7108
initial concentration: NaN

metaM lnlccoa c
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
name: linoleic coenzyme A
is: http://identifiers.org/pubchem.compound/5462164
initial amount: NaN
is: HMDB01064
boundary condition: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_793f5d34_3ca3_45a0_96ae_461deb6d0d97
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
type: Species
name: SLC8A3
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6547

metaR GLYGLYPEPT1tc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycyl-glycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR HIStN1
is: SBO:0000185
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reversible: true
reactant: MODEL1310110056#
product: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110056#
type: Reaction
name: Histidine transport (Na, H coupled)

http://identifiers.org/biomodels.db/MODEL1310110056#_88d0bf5f_007b_48a9_8fc5_48be9a083fb5
constant: false
has only substance units: false
is: Q9NUB1
is encoded by: hsa:84532
is: SBO:0000252
boundary condition: true
type: Species
name: ACSS1
initial amount: NaN
initial concentration: NaN

metaM 10fthf5glu e
is: CHEBI:58190
type: Species
constant: false
has only substance units: false
name: 10-formyltetrahydrofolate-[Glu](5)
boundary condition: false
is: HMDB00224
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C40H45N11O19 CHARGE: -6

metaR ADPtx
is: SBO:0000185
name: ADP transporter, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
reactant: MODEL1310110056#
reversible: true
product: MODEL1310110056#
is described by: ECO:0000000
kinetic law: MODEL1310110056#
type: Reaction
fast: false

metaR CYTK1m
reversible: true
reactant: MODEL1310110056#
fast: false
type: Reaction
kinetic law: MODEL1310110056#
name: cytidylate kinase (CMP),mitochondrial
is: SBO:0000176
product: MODEL1310110056#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion

http://identifiers.org/biomodels.db/MODEL1310110056#_e58d6f5f_6938_4a6b_8611_be875f2114c7
boundary condition: true
is encoded by: hsa:7991
type: Species
initial concentration: NaN
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
is: SBO:0000297
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_7bc41155_1a25_4a0f_9cac_e8ef9ed5b2c9
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
name: ACY3
initial amount: NaN
is: Q96HD9
is encoded by: hsa:91703

metaR GAL3ST11
kinetic law: MODEL1310110056#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
name: Galactosylceramide sulfotransferase
modifier: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110056#
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.8.2.11

metaR RE1532M
product: MODEL1310110056#
name: RE1532
reactant: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
modifier: MODEL1310110056#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110056#

metaM g1m8masn r
boundary condition: false
is: C05875
initial amount: NaN
type: Species
notes: FORMULA: C76H127N2O60X CHARGE: 0
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
constant: false

metaR CYTK9
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110056#
fast: false
name: cytidylate kinase (CMP,dCTP)
type: Reaction
product: MODEL1310110056#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR F6Tg
reactant: MODEL1310110056#
fast: false
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.4.1.68
reversible: false
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
name: glycoprotein 6-alpha-L-fucosyltransferase
type: Reaction
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#

metaM orot e
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: HMDB00226
initial amount: NaN
is: SBO:0000247
name: orotate
type: Species
is: CHEBI:30839
has only substance units: false

metaR r1544
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110056#
is: SBO:0000185
reactant: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_5595352d_8dd3_4f8e_8fe0_a1c0ef35f2e9
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: _T83654_1_c
is encoded by: hsa:T83654
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_b2eabaaa_3dd1_4397_865b_cfb490b1c0a1
has only substance units: false
is encoded by: hsa:47
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
name: ACLY
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_19115550_7290_454f_95ec_0e1a0cd56b02
type: Species
is: SBO:0000252
is encoded by: hsa:BE966236
boundary condition: true
constant: false
initial amount: NaN
name: _BE966236_1_m
has only substance units: false
initial concentration: NaN

metaM arachdcrn x
constant: false
is: CHEBI:17490
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: C20:4 carnitine
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
type: Species
has only substance units: false
initial amount: NaN
is: HMDB00222

metaM ksi pre20 g
is: CHEBI:28067
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
is: SBO:0000247
constant: false
name: keratan sulfate I biosynthesis, precursor 20
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR 5ADTSTSTERONEtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
type: Reaction
kinetic law: MODEL1310110056#
reversible: true
reactant: MODEL1310110056#
fast: false
name: 5 alpha dihydrotesterone intracellular transport
product: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000185

metaR 3MOX4HOXPGALDOX
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000304
product: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
reversible: false
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase
is: SBO:0000176
type: Reaction

metaR HAtly
product: MODEL1310110056#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: hyaluronan transport, extracellular to lysosome

metaR FAOXC5C3x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C3)m
type: Reaction

metaM HC00319 c
boundary condition: false
initial concentration: 1.0
is: CHEBI:30794
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
constant: false
initial amount: NaN
name: Malonate
type: Species

metaR r0027
reversible: true
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.14.13.39
product: MODEL1310110056#
fast: false
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
is described by: ECO:0000000
reactant: MODEL1310110056#
type: Reaction

metaM cs a deg1 l
has only substance units: false
is: CHEBI:16953
initial amount: NaN
initial concentration: 1.0
is: HMDB00812
type: Species
constant: false
boundary condition: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
is: SBO:0000247

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaM acetone m
has only substance units: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:15347
constant: false
is: HMDB01659
name: acetone
boundary condition: false

metaM abt c
name: L-arabinitol
is: HMDB01851
is: CHEBI:18403
is: SBO:0000247
type: Species
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
initial concentration: 1.0
initial amount: NaN

metaR GLYt7 211 r
reversible: true
name: glycine reversible transport via sodium and chloride symport (2:1:1)
type: Reaction
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
kinetic law: MODEL1310110056#
is: SBO:0000185
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_28b5efc9_1dbd_4d20_a4ae_6b36f48c1897
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:6817
has only substance units: false
name: SULT1A1
boundary condition: true
initial concentration: NaN

metaR THRALANaEx
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
fast: false
type: Reaction
product: MODEL1310110056#
is: SBO:0000185
modifier: MODEL1310110056#
reversible: false
name: L-alanine/L-threonine Na-dependent exchange (Thr-L in)

http://identifiers.org/biomodels.db/MODEL1310110056#_b764357e_d44c_4701_a559_75a489f65d8b
initial amount: NaN
boundary condition: true
has part: Q9HCC0
has only substance units: false
initial concentration: NaN
has part: Q96RQ3
is: SBO:0000297
constant: false
type: Species
is encoded by: hsa:56922
name: MCCC1:MCCC2
is encoded by: hsa:64087

metaM tetpent6coa c
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
boundary condition: false
name: tetracosapentaenoyl coenzyme A, n-6
is: C16172
constant: false
is: SBO:0000247
initial amount: NaN

metaR FAOXC185m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

metaM 2oxoadp m
is: SBO:0000247
is: HMDB00225
name: 2-oxoadipate(2-)
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
constant: false
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:57499

metaR r1651
modifier: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110056#_22f95ff9_a4d5_40e4_9501_38cfe8867b84
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: HAGH
type: Species
initial concentration: NaN
is encoded by: hsa:3029
has only substance units: false
is: Q16775

http://identifiers.org/biomodels.db/MODEL1310110056#_c3d673ed_c056_4a67_9f35_18dfd7b9fa47
initial concentration: NaN
is: Q10471
is encoded by: hsa:2590
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
name: GALNT2

metaM pe hs m
is: SBO:0000247
boundary condition: false
constant: false
type: Species
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
is: CHEBI:16038
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM HC00695 m
name: S-Succinyldihydrolipoamide
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:17432
initial concentration: 1.0
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
boundary condition: false

metaM odecrn m
is: C00412
boundary condition: false
has only substance units: false
is: CHEBI:57394
name: octadecenoyl carnitine
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
type: Species
is: HMDB01114
initial concentration: 1.0
constant: false

metaM ksii core4 pre6 g
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:28067
constant: false
notes: FORMULA: C69H111N6O51SX CHARGE: -2
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 6
boundary condition: false
type: Species

metaM pmtcrn m
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
name: L-palmitoylcarnitine
is: SBO:0000247
is: CHEBI:17490
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00222

metaM 5eipencoa m
constant: false
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
is: SBO:0000247
name: 5,8,11,14,17-eicosapentenoylcoa

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaR SUCOASm
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.4
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/6.2.1.5
product: MODEL1310110056#
fast: false
reactant: MODEL1310110056#
name: Succinate--CoA ligase (ADP-forming)
is: SBO:0000176
kinetic law: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_2021254e_764c_4b49_bcb2_dae22c1bc2d2
is: Q9NY59
initial concentration: NaN
is encoded by: hsa:55512
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
name: SMPD3

metaR EX bglc LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for beta glucans
type: Reaction

metaM acetol c
is: HMDB06961
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:27957
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
name: hydroxyacetone
has only substance units: false
initial concentration: 1.0

metaM c3dc c
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
name: malonyl carnitine
notes: FORMULA: C10H16NO6 CHARGE: -1
boundary condition: false
initial concentration: 1.0
is: HMDB02095
type: Species

metaR CITRtm
name: citrulline mitochondrial transport via proton antiport
reactant: MODEL1310110056#
modifier: MODEL1310110056#
type: Reaction
fast: false
product: MODEL1310110056#
reversible: true
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV

http://identifiers.org/biomodels.db/MODEL1310110056#_055e0972_1993_46a1_9f2f_5cc426d55b51
name: SLC35D1
constant: false
initial amount: NaN
is: Q9NTN3
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:23169

metaM dec24dicoa x
is: HMDB01168
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
type: Species
name: 2,4-decadienoylcoa
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM nh4 c
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: HMDB00051
initial concentration: 1.0
constant: false
boundary condition: false
is: C01342
is: SBO:0000247
name: Ammonium
type: Species
initial amount: NaN
has only substance units: false

metaM prostgd2 c
is: CHEBI:57406
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: HMDB01403
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: prostaglandin D2(1-)

metaR r1650
type: Reaction
reactant: MODEL1310110056#
is: SBO:0000185
product: MODEL1310110056#
fast: false
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true

metaR AG13T9g
fast: false
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
is: SBO:0000176
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110056#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
reversible: false

metaM xol7ah c
constant: false
initial concentration: 1.0
is: CHEBI:2290
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: HMDB06892
name: 7alpha-hydroxy-5beta-cholestan-3-one

metaM ksi pre29 g
initial amount: NaN
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
boundary condition: false
type: Species
constant: false
is: CHEBI:28067
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 29
is: SBO:0000247
has only substance units: false

metaM gal l
is: HMDB00143
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:12936
constant: false
initial concentration: 1.0
name: D-galactose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
type: Species

metaM phaccoa c
name: phenylacetyl-CoA(4-)
constant: false
is: CHEBI:57390
is: HMDB06503
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR C226CPT1
fast: false
product: MODEL1310110056#
name: carnitine C22:6 transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
type: Reaction
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000

metaM HC01415 m
is: CHEBI:27537
constant: false
initial concentration: 1.0
initial amount: NaN
name: (2E)-Octenoyl-CoA
is: SBO:0000247
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
type: Species
has only substance units: false
boundary condition: false

metaR FUMTSULtm
reversible: true
fast: false
type: Reaction
is described by: ECO:0000269
name: Fumarate:thiosulfate antiport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000185
product: MODEL1310110056#
modifier: MODEL1310110056#

metaM abt e
constant: false
type: Species
name: L-arabinitol
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
initial concentration: 1.0
has only substance units: false
is: HMDB01851
is: SBO:0000247
is: CHEBI:18403

metaM dcholcoa r
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB06292
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
name: chenodeoxycholoyl coenzyme a
constant: false
has only substance units: false
is: CHEBI:28701
is: SBO:0000247

metaR r0870
is version of: http://identifiers.org/ec-code/2.7.7.72
is version of: http://identifiers.org/ec-code/3.6.4.13
type: Reaction
kinetic law: MODEL1310110056#
is described by: ECO:0000000
product: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.4
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.6.1.1
is: SBO:0000185
name: Facilitated diffusion
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_514738f5_9636_4558_b468_2f1ad541728b
initial amount: NaN
type: Species
name: _AI024818_1_c
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:AI024818
initial concentration: NaN

metaM gal1p c
is: HMDB00645
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:58336
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
constant: false
initial amount: NaN
has only substance units: false
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate

metaR r1653
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110056#
type: Reaction
fast: false
reversible: true
product: MODEL1310110056#

metaM hs deg19 l
initial amount: NaN
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
is: SBO:0000247
name: heparan sulfate, degradation product 19
is: HMDB06210
constant: false
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0

metaR C181CRNt
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110056#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: C181 transport into the mitochondria
product: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
modifier: MODEL1310110056#

metaR TRPHYDRO2
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
reversible: false
is version of: http://identifiers.org/ec-code/1.14.16.4
is: SBO:0000176
product: MODEL1310110056#
type: Reaction
fast: false
modifier: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
is described by: ECO:0000269

metaM pap c
name: adenosine 3',5'-bismonophosphate(4-)
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:58343
initial amount: NaN
is: HMDB00061
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054

http://identifiers.org/biomodels.db/MODEL1310110056#_e0823fc9_17bd_4dac_81cb_f554c832771b
has only substance units: false
is encoded by: hsa:8309
type: Species
boundary condition: true
initial concentration: NaN
is: Q99424
is: SBO:0000252
constant: false
initial amount: NaN
name: ACOX2

metaM s2l2n2m2masn e
is: C00255
is: HMDB00244
initial amount: NaN
notes: FORMULA: C84H135N6O61X CHARGE: -2
name: de-Fuc form of PA6
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:3554
type: Species
has only substance units: false
initial concentration: 1.0

metaR C226CPT2
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
reversible: false
reactant: MODEL1310110056#
is: SBO:0000176
kinetic law: MODEL1310110056#
fast: false
name: C226 transport into the mitochondria
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_fb645d19_6659_4ef7_b770_f2dcc16e0805
is: Q9GZS9
constant: false
name: CHST5
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:23563
initial amount: NaN

metaR r1652
reactant: MODEL1310110056#
is: SBO:0000185
fast: false
product: MODEL1310110056#
is described by: ECO:0000000
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true

metaM nh4 e
is: CHEBI:28938
is: HMDB00051
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
name: ammonium

http://identifiers.org/biomodels.db/MODEL1310110056#_462be861_9e1f_46c4_a081_7fd464289d49
is encoded by: hsa:3712
initial concentration: NaN
has only substance units: false
constant: false
is: B3KVI7
initial amount: NaN
boundary condition: true
type: Species
name: IVD
is: SBO:0000252

metaR FAOXC7C5m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C7-->C5)m
type: Reaction

metaM prostgd2 e
is: HMDB01403
boundary condition: false
constant: false
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin D2(1-)
is: CHEBI:57406

metaR G14T20g
reactant: MODEL1310110056#
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110056#
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110056#
is described by: ECO:0000000

metaR GLYtm
name: glycine passive transport to mitochondria
kinetic law: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
is: SBO:0000185
reversible: true
product: MODEL1310110056#
is described by: ECO:0000000
reactant: MODEL1310110056#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_fa4b362e_582c_4e88_82e7_a241c1e16ab4
has only substance units: false
constant: false
boundary condition: true
type: Species
is: SBO:0000252
name: UROD
is: P06132
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:7389

metaR r1655
reversible: true
product: MODEL1310110056#
is: SBO:0000185
reactant: MODEL1310110056#
fast: false
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR FAOXC13C11m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C13-->C11)m
type: Reaction

metaR DCMPDA
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110056#
name: dCMP deaminase
product: MODEL1310110056#
is described by: ECO:0000254
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
fast: false
modifier: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.12

metaR LDH D
reversible: true
is version of: http://identifiers.org/ec-code/1.1.2.4
fast: false
reactant: MODEL1310110056#
product: MODEL1310110056#
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
is: SBO:0000176
type: Reaction
is described by: ECO:0000304
name: D-lactate dehydrogenase

http://identifiers.org/biomodels.db/MODEL1310110056#_57cdd379_11b7_45fb_a144_4b38152a38a9
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is: Q5MY95
initial amount: NaN
is encoded by: hsa:377841
has only substance units: false
boundary condition: true
name: ENTPD8

http://identifiers.org/biomodels.db/MODEL1310110056#_41a5ae79_95f2_4af6_bcab_9b113e5ac1c8
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P48067
boundary condition: true
name: SLC6A9
initial amount: NaN
is encoded by: hsa:6536
constant: false

metaR SCPx
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
kinetic law: MODEL1310110056#
is: SBO:0000176
name: peroxisomal thiolase 2
reactant: MODEL1310110056#
modifier: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.176
reversible: false
is described by: ECO:0000269
fast: false

metaR ECOAH9m
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
reactant: MODEL1310110056#
reversible: true
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
is: SBO:0000176
product: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
kinetic law: MODEL1310110056#

metaR MGCHrm
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.18
reactant: MODEL1310110056#
modifier: MODEL1310110056#
type: Reaction
fast: false
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
reversible: true
is described by: ECO:0000269
product: MODEL1310110056#

metaR EX 9 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 9-cis-retinol exchange
type: Reaction

metaR DINt
is: SBO:0000185
product: MODEL1310110056#
reactant: MODEL1310110056#
name: deoxyinosine transport via diffusion
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110056#_933d10a6_7cee_4b31_9f64_b0cf79a69878
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:212
name: ALAS2
is: Q5JZF5

metaR r1378
fast: false
product: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110056#
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
is described by: ECO:0000000

metaR SBCOAACOTx
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of suberyl coa for release into cytosol
type: Reaction

metaR r1654
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110056#
is: SBO:0000185
reactant: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#

metaR r1549
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110056#
product: MODEL1310110056#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110056#_78235700_f452_4e0c_ba85_6073cf50b74f
is encoded by: hsa:10449
boundary condition: true
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is: P42765
initial concentration: NaN
initial amount: NaN
name: ACAA2

metaR G6PDH2rer
product: MODEL1310110056#
reversible: true
type: Reaction
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
reactant: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.1.1.47
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
fast: false

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaR S2TASE3ly
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.13
product: MODEL1310110056#
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
reversible: false
name: iduronate-2-sulfatase, lysosomal
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110056#
is described by: ECO:0000000

metaR r0130
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is described by: ECO:0000000
fast: false
product: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#

metaM pe hs r
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:16038
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false

metaM dgchol e
has only substance units: false
initial amount: NaN
name: glycochenodeoxycholate
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial concentration: 1.0
is: CHEBI:36252
constant: false
is: HMDB00637
is: SBO:0000247
type: Species
boundary condition: false

metaR r1377
is described by: ECO:0000000
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
fast: false
type: Reaction
reversible: true
is: SBO:0000176

metaR r0720
fast: false
is: SBO:0000176
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110056#
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: false

metaR HDCACBP
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM tdcoa x
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: SBO:0000247
is: C02593
constant: false
type: Species
initial concentration: 1.0
name: Tetradecanoyl-CoA (n-C14:0CoA)
initial amount: NaN
is: CHEBI:57385
is: HMDB01521
boundary condition: false
has only substance units: false

metaR LALDO2x
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF
fast: false
reactant: MODEL1310110056#
is: SBO:0000176
reversible: false
modifier: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000269
name: D-Lactaldehyde:NAD+ 1-oxidoreductase
type: Reaction
kinetic law: MODEL1310110056#

metaR r1657
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
product: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#
is described by: ECO:0000000
kinetic law: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110056#

metaR SGPL12r
kinetic law: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
modifier: MODEL1310110056#
name: Sphingosine-1-phosphate lyase
is described by: ECO:0000304
reactant: MODEL1310110056#
product: MODEL1310110056#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.2.27
fast: false
is: SBO:0000176

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaR C8CRNe
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octanoyl carnitine into the extra cellular space
type: Reaction

metaM pap g
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
is: SBO:0000247
is: CHEBI:58343
constant: false
is: HMDB00061
name: adenosine 3',5'-bismonophosphate(4-)
boundary condition: false
type: Species
has only substance units: false

metaR BACCLm
is described by: ECO:0000254
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
reactant: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.10
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
reversible: false
fast: false
is: SBO:0000176

metaR r0721
reactant: MODEL1310110056#
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: false
type: Reaction
is described by: ECO:0000000
fast: false

metaR FADH2tx
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110056#
type: Reaction
fast: false
product: MODEL1310110056#
name: FADH2 transporter, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
kinetic law: MODEL1310110056#

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

metaM HC00319 m
is: SBO:0000247
boundary condition: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial amount: NaN
name: Malonate
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:30794
type: Species

metaM hdd2crn m
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: trans-Hexadec-2-enoyl carnitine
initial amount: NaN
constant: false
is: HMDB06317
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+

metaR r1656
kinetic law: MODEL1310110056#
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110056#

metaM 5dpmev c
is: HMDB01090
name: (R)-5-Diphosphomevalonate
is: SBO:0000247
constant: false
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false

metaR CYTK1
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110056#
type: Reaction
name: cytidylate kinase (CMP)
reactant: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110056#

metaM cs a deg3 l
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:15748
notes: FORMULA: C31H48NO32S2 CHARGE: -3
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
initial amount: NaN
type: Species
constant: false
is: HMDB00127
boundary condition: false

metaM nadp m
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:58349
type: Species
is: C00006
is: SBO:0000247
is: HMDB00217
name: Nicotinamide adenine dinucleotide phosphate
initial concentration: 1.0

metaM dlnlcgcoa m
name: dihomo-gamma-linolenyl coenzyme A
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:27979
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM lnlccoa m
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5462164
has only substance units: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
constant: false
is: SBO:0000247
name: linoleic coenzyme A
is: HMDB01064

metaR VITD3tm3
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is transported from cytosol in mitochondria based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
kinetic law: MODEL1310110056#
product: MODEL1310110056#
fast: false
is: SBO:0000185
name: Vitamin D3 transport in mitochondria
reversible: false
reactant: MODEL1310110056#

metaR r0722
product: MODEL1310110056#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reversible: true
kinetic law: MODEL1310110056#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.3.12
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
modifier: MODEL1310110056#

metaR RE0944E
fast: false
name: RE0944
reactant: MODEL1310110056#
is: SBO:0000176
product: MODEL1310110056#
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.1
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.17
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_08f7c4b6_12c4_4b9e_b9dd_b2790ad80180
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
is encoded by: hsa:122622
name: ADSSL1
is: SBO:0000252
is: B3KTV4
initial amount: NaN

metaM co2 x
constant: false
name: carbon dioxide
is: HMDB01967
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:16526
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011

metaR r1375
type: Reaction
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000000
reversible: false
name: Transport reaction
is: SBO:0000185
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
fast: false

metaM c3dc e
notes: FORMULA: C10H16NO6 CHARGE: -1
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB02095
name: malonyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110056#_d84b0cef_4b55_4dd2_9d4e_f8364a6e74ac
type: Species
boundary condition: true
is: P20674
initial amount: NaN
is encoded by: hsa:9377
has only substance units: false
name: COX5A
initial concentration: NaN
constant: false
is: SBO:0000252

metaR FAOXC142C142OHm
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C14:2OH)m
type: Reaction

metaR r2389
modifier: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
product: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_d3b5916a_271f_4949_bdb8_49c565b3fa3a
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8622
is: SBO:0000252
is: O95263
name: PDE8B
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_771f5c87_9b39_4ba0_aac6_4104356f78e3
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:4357
name: MPST
boundary condition: true
type: Species
is: P25325
has only substance units: false

metaM HC02203 e
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:27820
name: prostaglandin-a2

http://identifiers.org/biomodels.db/MODEL1310110056#_75c04360_7b81_4da1_bb89_757a871eaa3f
type: Species
name: PPA2
has only substance units: false
is encoded by: hsa:27068
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaR FAOXC161802m
reactant: MODEL1310110056#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
name: Beta oxidation fatty acid
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR r0596
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
reversible: false
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#

metaR CYOR u10m
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110056#
product: MODEL1310110056#
name: ubiquinol-6 cytochrome c reductase, Complex III
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.92
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_986399a5_ea31_49dc_b3ec_f8886fde7fc7
boundary condition: true
name: CLC
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: C5HZ13
is encoded by: hsa:1178
constant: false
has only substance units: false
type: Species

metaR FAOXC5C5OHm
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C5OH)m
type: Reaction

metaR VALt5m
type: Reaction
kinetic law: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110056#
reversible: true
name: Valine reversible mitochondrial transport

metaR r0403
reversible: true
reactant: MODEL1310110056#
type: Reaction
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.2.4.4
fast: false

metaM cmp n
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:60377
is: HMDB00095
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
name: CMP(2-)
boundary condition: false

metaR GLNtN1
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110056#
name: Glutamine transport (Na, H coupled)
modifier: MODEL1310110056#
fast: false
type: Reaction
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reversible: true
kinetic law: MODEL1310110056#

metaM ocdcea e
is: C00712
is: HMDB00207
type: Species
notes: FORMULA: C18H33O2 CHARGE: -1
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
name: octadecenoate (n-C18:1)
is: CHEBI:0

metaM CE2434 m
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:57795
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
type: Species
constant: false
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110056#_a84786b7_2d18_476e_853b_e1eb19e0aad5
has only substance units: false
name: _AI378339_1_m
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:AI378339
initial amount: NaN

metaM xol7ah2 c
initial amount: NaN
is: HMDB06893
initial concentration: 1.0
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha-diol
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: CHEBI:28047
boundary condition: false
type: Species
is: SBO:0000247
constant: false

metaR PTCRTD
reversible: true
name: diffusion of putriscine into the endothelial cells
is described by: ECO:0000134
type: Reaction
product: MODEL1310110056#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#

metaM glyald c
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
name: D-Glyceraldehyde
is: C00577
is: CHEBI:17378
initial concentration: 1.0
is: HMDB01051
boundary condition: false
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577

metaM amp x
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: SBO:0000247
is: CHEBI:456215
type: Species
initial concentration: 1.0
has only substance units: false
name: AMP
is: HMDB00045
boundary condition: false
is: C00020
initial amount: NaN

metaR RE2814M
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110056#
type: Reaction
name: RE2814
fast: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is: SBO:0000176

metaM pe hs e
initial concentration: 1.0
constant: false
name: phosphatidylethanolamine
is: CHEBI:16038
type: Species
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM gly e
is: SBO:0000247
is: CHEBI:3339
initial amount: NaN
name: Glycine
type: Species
notes: FORMULA: C2H5NO2 CHARGE: 0
initial concentration: 1.0
boundary condition: false
is: C00037
constant: false
has only substance units: false
is: HMDB00123

metaM ascb L e
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: CHEBI:38290
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
name: L-ascorbate
is: HMDB00044

metaM tetdec2coa c
is: HMDB02014
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
name: tetradecadienoylcoa
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
constant: false

metaM acetone e
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
name: acetone
boundary condition: false
is: HMDB01659
initial amount: NaN
is: CHEBI:15347
constant: false
type: Species
initial concentration: 1.0

metaM 4mzym int1 r
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
type: Species
is: HMDB06927
initial amount: NaN
boundary condition: false
name: 4-Methylzymosterol intermediate 1

metaM creat c
is: SBO:0000247
name: creatine
type: Species
is: HMDB00064
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
boundary condition: false
initial concentration: 1.0
is: CHEBI:16919

metaR r0714
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000000
reactant: MODEL1310110056#
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35

metaR r2387
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110056#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
reactant: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_c0dc3abe_e4ac_4a6e_8fcb_1fceeccf3121
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is: B4DG68
initial amount: NaN
name: NOS1
boundary condition: true
is encoded by: hsa:4842

metaM m8masn r
boundary condition: false
is: C05876
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C70H117N2O55X CHARGE: 0
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

metaR r0594
modifier: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000176
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
reactant: MODEL1310110056#

metaM hs deg12 l
name: heparan sulfate, degradation product 12
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB06210
has only substance units: false

metaR r2014
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110056#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
reactant: MODEL1310110056#
product: MODEL1310110056#
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_c18a745e_bc7b_4523_a933_548d16fe565f
name: SLC2A9
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:56606
is: Q9NRM0
constant: false

metaM HC02203 c
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial amount: NaN
is: SBO:0000247
constant: false
name: prostaglandin-a2
is: CHEBI:27820

http://identifiers.org/biomodels.db/MODEL1310110056#_bd610026_63c7_455b_93e6_c1ee8dd11633
initial concentration: NaN
is: P15289
type: Species
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:410
is: SBO:0000252
name: ARSA
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_5e5622df_3833_4232_bb9c_014fda7fd8b1
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
name: AK2
is encoded by: hsa:204
initial amount: NaN
constant: false
is: SBO:0000252

metaR FRDPtc
is: SBO:0000185
product: MODEL1310110056#
reversible: true
fast: false
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
type: Reaction
reactant: MODEL1310110056#

metaR HIStiDF
fast: false
modifier: MODEL1310110056#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110056#
reversible: false
kinetic law: MODEL1310110056#
name: L-histidine transport via diffusion (extracellular to cytosol)
notes: GENE_ASSOCIATION: (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES:SAB
reactant: MODEL1310110056#

metaR r2388
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
kinetic law: MODEL1310110056#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110056#
reversible: false
reactant: MODEL1310110056#
type: Reaction
product: MODEL1310110056#

metaM accoa x
is: HMDB01206
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
boundary condition: false
name: Acetyl-CoA
is: C00024
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:57288
initial amount: NaN
has only substance units: false
type: Species

metaR GLCNACASE3ly
fast: false
name: alpha-N-acetylglucosaminidase, lysosomal
type: Reaction
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000
reversible: false
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.50

metaM dec24dicoa m
is: HMDB01168
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
name: 2,4-decadienoylcoa
has only substance units: false

metaM atp n
is: HMDB00538
is: SBO:0000247
has only substance units: false
name: ATP(3-)
type: Species
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
is: CHEBI:57299
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN

metaM coucoa m
initial concentration: 1.0
is: CHEBI:57355
is: C00223
type: Species
notes: FORMULA: C30H38N7O18P3S1 CHARGE: -4 INCHI: InChI=1S/C30H42N7O18P3S/c1-30(2,25(42)28(43)33-10-9-20(39)32-11-12-59-21(40)8-5-17-3-6-18(38)7-4-17)14-52-58(49,50)55-57(47,48)51-13-19-24(54-56(44,45)46)23(41)29(53-19)37-16-36-22-26(31)34-15-35-27(22)37/h3-8,15-16,19,23-25,29,38,41-42H,9-14H2,1-2H3,(H,32,39)(H,33,43)(H,47,48)(H,49,50)(H2,31,34,35)(H2,44,45,46)/p-4/t19-,23-,24-,25+,29-/m1/s1
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
name: 4-coumaroyl-CoA(4-)
has only substance units: false

metaR ADK1m
reactant: MODEL1310110056#
fast: false
modifier: MODEL1310110056#
type: Reaction
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.3
name: adenylate kinase, mitochondrial
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110056#
product: MODEL1310110056#

metaR r0400
is version of: http://identifiers.org/ec-code/1.2.4.4
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_e53335c2_b867_4383_9d8a_58febed8ba8f
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
name: _AI926493_1_m
initial amount: NaN
is encoded by: hsa:AI926493
is: SBO:0000252
type: Species

metaM ascb L c
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00044
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
boundary condition: false
name: L-ascorbate
is: CHEBI:38290
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_9e6b47fb_2a56_4529_9d28_d0f1e7c65b0e
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:64902
name: AGXT2
is: Q9BYV1
constant: false
boundary condition: true

metaM co2 m
name: CO2
constant: false
boundary condition: false
is: SBO:0000247
is: C00011
type: Species
initial amount: NaN
is: HMDB01967
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial concentration: 1.0
has only substance units: false
is: CHEBI:16526

metaM cmp m
constant: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: CHEBI:60377
is: HMDB00095
initial concentration: 1.0
has only substance units: false
name: CMP(2-)

metaR r0716
fast: false
product: MODEL1310110056#
is: SBO:0000176
type: Reaction
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
kinetic law: MODEL1310110056#
reversible: false
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:

metaM em2emgacpail hs r
initial amount: NaN
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16038
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
type: Species
constant: false
has only substance units: false

metaM atp m
is: C00002
type: Species
name: ATP(4-)
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB00538
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57299

http://identifiers.org/biomodels.db/MODEL1310110056#_7c28d03b_43d4_464d_853a_9c95c17c15b4
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
name: PIGP
is encoded by: hsa:51227

metaM cdpdag hs m
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
is: CHEBI:58332
name: CDP-diacylglycerol(2-)
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR TXASr
reactant: MODEL1310110056#
reversible: false
product: MODEL1310110056#
fast: false
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/5.3.99.5
is described by: ECO:0000134
type: Reaction
name: Thromboxane-A synthase
kinetic law: MODEL1310110056#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ

metaM nadp c
is: HMDB00217
is: C00006
has only substance units: false
is: CHEBI:58349
boundary condition: false
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
constant: false

metaM dlnlcg c
name: dihomo-gamma-linolenic acid (n-6)
type: Species
initial concentration: 1.0
is: CHEBI:53486
boundary condition: false
has only substance units: false
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
is: SBO:0000247
is: HMDB02925
constant: false
initial amount: NaN

metaR DM ethamp r
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_6bcaed0a_9c6d_4caf_9f4f_4d38d72ebdce
is encoded by: hsa:51
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is: B4DK61
initial amount: NaN
name: ACOX1
has only substance units: false

metaM creat e
is: HMDB00064
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
name: creatine
is: SBO:0000247
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
boundary condition: false
constant: false
is: CHEBI:16919

metaR APOCFm
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
is described by: ECO:0000000
reactant: MODEL1310110056#
name: Apocarboxylase formation, mitochondrial
kinetic law: MODEL1310110056#
fast: false
product: MODEL1310110056#
is: SBO:0000176

metaR ACACT7p
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
is: SBO:0000176
product: MODEL1310110056#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000269
modifier: MODEL1310110056#

metaR r2385
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
modifier: MODEL1310110056#
is: SBO:0000185
reactant: MODEL1310110056#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reversible: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#

metaR CYSO
is described by: ECO:0000269
kinetic law: MODEL1310110056#
product: MODEL1310110056#
name: cysteine oxidase
fast: false
modifier: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/1.13.11.20
reversible: false
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
is: SBO:0000176

metaM co2 r
initial amount: NaN
is: HMDB01967
has only substance units: false
is: CHEBI:16526
constant: false
name: CO2
is: C00011
is: SBO:0000247
type: Species
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
boundary condition: false
initial concentration: 1.0

metaM dlnlcgcoa c
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
name: dihomo-gamma-linolenyl coenzyme A
is: CHEBI:27979
has only substance units: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
initial amount: NaN

metaR r0407
is version of: http://identifiers.org/ec-code/1.4.3.5
type: Reaction
product: MODEL1310110056#
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
modifier: MODEL1310110056#
reversible: true
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13

metaM s2l2n2m2masn l
initial amount: NaN
notes: FORMULA: C84H135N6O61X CHARGE: -2
name: de-Fuc form of PA6
is: CHEBI:18287
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00174
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_cd4cef05_e18a_4022_a463_d8afcbc28944
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q8N695
name: SLC5A8
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:160728
constant: false

metaM leuktrB4 c
name: leukotriene B4(1-)
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: CHEBI:57461
has only substance units: false
initial amount: NaN
is: HMDB01085
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_8f5dd167_de60_4857_9abf_8dc48e41f53e
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
name: GMPS
is: P49915
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:8833

metaR r0591
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110056#
is: SBO:0000176
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110056#
fast: false
reversible: true
kinetic law: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:

metaR TYRCBOX
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
name: L-Tyrosine carboxy-lyase
reversible: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.1.1.28
type: Reaction
modifier: MODEL1310110056#
product: MODEL1310110056#
fast: false
reactant: MODEL1310110056#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110056#_5de0bbc9_64a4_4c48_ad07_b0643adf617f
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:56474
initial concentration: NaN
has only substance units: false
constant: false
name: CTPS2
is: Q9NRF8
boundary condition: true

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaR ASNTHRNaEx
is described by: ECO:0000269
name: L-threonine/L-asparagine Na-dependent exchange (Asn-L in)
is: SBO:0000185
reactant: MODEL1310110056#
product: MODEL1310110056#
reversible: false
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110056#
fast: false
type: Reaction

metaR PI45PLC
is: SBO:0000176
reactant: MODEL1310110056#
reversible: false
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
is described by: ECO:0000000
fast: false
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.4.11
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
type: Reaction
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_6e5ae9d0_baa4_4aa5_9deb_88d8bfdfdab8
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:27068
name: PPA2

http://identifiers.org/biomodels.db/MODEL1310110056#_a73a8e2f_395e_4684_9c7c_02d74a36c1dc
initial amount: NaN
boundary condition: true
name: FLAD1
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:80308
initial concentration: NaN
has only substance units: false

metaR NTD4e
kinetic law: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reactant: MODEL1310110056#
name: 5'-nucleotidase (CMP), extracellular
is described by: ECO:0000134
modifier: MODEL1310110056#
reversible: false
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
is: SBO:0000176

metaR r0715
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reactant: MODEL1310110056#
is: SBO:0000176
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.2.5
is described by: ECO:0000000
modifier: MODEL1310110056#
product: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaR r2386
fast: false
reversible: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
modifier: MODEL1310110056#
reactant: MODEL1310110056#

metaM ksi deg17 l
name: keratan sulfate I, degradation product 17
constant: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
is: HMDB00143
initial amount: NaN
is: CHEBI:12936
has only substance units: false
initial concentration: 1.0

metaM val L e
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:16414
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: HMDB00883
name: L-valine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_228df45f_158e_4162_a431_86101f022541
is: C9JC79
initial amount: NaN
is encoded by: hsa:6342
type: Species
name: SCP2
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN

metaR FAOXC184x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:4)x
type: Reaction

metaR VITD3Hm
is: SBO:0000176
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:7690968 NOTES:based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.196 IT; RE1303M
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110056#
fast: false
product: MODEL1310110056#
modifier: MODEL1310110056#
name: Vitamin D-25-hydroxylase (D3)
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110056#

metaM pmtcrn r
is: CHEBI:17490
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
name: L-palmitoylcarnitine
initial amount: NaN
is: HMDB00222
initial concentration: 1.0
type: Species

metaR AG13T8g
reactant: MODEL1310110056#
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110056#
modifier: MODEL1310110056#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110056#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149

metaR r0590
fast: false
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:

metaR r0718
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
product: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.181
is described by: ECO:0000000
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reactant: MODEL1310110056#
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_802f2b23_c1e9_4bb0_8b4a_cffc5eb015db
type: Species
initial amount: NaN
initial concentration: NaN
is: Q16134
is encoded by: hsa:2110
is: SBO:0000252
constant: false
boundary condition: true
name: ETFDH
has only substance units: false

metaM hexccoa x
is: HMDB06459
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C47H82N7O17P3S CHARGE: -4 INCHI: InChI=1/C47H86N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-38(56)75-31-30-49-37(55)28-29-50-45(59)42(58)47(2,3)33-68-74(65,66)71-73(63,64)67-32-36-41(70-72(60,61)62)40(57)46(69-36)54-35-53-39-43(48)51-34-52-44(39)54/h34-36,40-42,46,57-58H,4-33H2,1-3H3,(H,49,55)(H,50,59)(H,63,64)(H,65,66)(H2,48,51,52)(H2,60,61,62)/p-4/t36-,40-,41-,42+,46-/m1/s1
initial amount: NaN
type: Species
has only substance units: false
name: Hexacosanoyl-CoA (n-C26:0CoA)

metaM dlnlcg e
is: SBO:0000247
boundary condition: false
is: CHEBI:53486
has only substance units: false
name: dihomo-gamma-linolenic acid (n-6)
constant: false
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
initial concentration: 1.0
is: HMDB02925
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_51886b01_4600_4971_887a_cc8d2dc4d04f
is: SBO:0000252
type: Species
name: GALNT5
constant: false
initial concentration: NaN
is: A5PKZ1
boundary condition: true
initial amount: NaN
is encoded by: hsa:11227
has only substance units: false

metaM ocdcea c
notes: FORMULA: C18H33O2 CHARGE: -1
is: C00712
initial concentration: 1.0
has only substance units: false
is: CHEBI:0
is: HMDB00207
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
name: octadecenoate (n-C18:1)
boundary condition: false

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaM leuktrB4 e
type: Species
name: leukotriene B4(1-)
initial concentration: 1.0
boundary condition: false
is: CHEBI:57461
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: HMDB01085
has only substance units: false
constant: false
is: SBO:0000247

metaR SUCCACT
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of succinate
type: Reaction

metaR MAGt
reactant: MODEL1310110056#
fast: false
name: monoacylglycerol 2 transport
kinetic law: MODEL1310110056#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:10344773 NOTES:
type: Reaction
product: MODEL1310110056#
is described by: ECO:0000269

metaM gly c
is: SBO:0000247
name: Glycine
initial concentration: 1.0
boundary condition: false
is: CHEBI:3339
notes: FORMULA: C2H5NO2 CHARGE: 0
initial amount: NaN
has only substance units: false
is: C00037
type: Species
constant: false
is: HMDB00123

metaR BMTer L
name: B mannosyltransferase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
type: Reaction
modifier: MODEL1310110056#
is described by: ECO:0000000
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
reversible: false
product: MODEL1310110056#
is: SBO:0000176
fast: false

metaM val L c
initial concentration: 1.0
initial amount: NaN
is: HMDB00883
name: L-valine
is: CHEBI:16414
boundary condition: false
has only substance units: false
type: Species
constant: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: SBO:0000247

metaR r0717
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110056#
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: false

metaR MDHx
fast: false
name: malate dehydrogenase, peroxisomal
is described by: ECO:0000134
product: MODEL1310110056#
type: Reaction
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: Confidence Level: 2 AUTHORS: PMID: 17173541 NOTES:added during gap filling. Assumption that such a reaction can exist. Mamalian peroxisome do not contain malate dehydrogenase.
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_96aa6aa8_3a47_49ca_8bde_a0ff2e12fd70
initial amount: NaN
is encoded by: hsa:5730
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
name: PTGDS
is: P41222
boundary condition: true

metaM ksi pre27 g
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:58053
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 27
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
constant: false
is: HMDB00175
initial amount: NaN
type: Species
is: C00130

metaR r2384
reversible: false
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
fast: false
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110056#
type: Reaction

metaM acetone c
boundary condition: false
is: HMDB01659
is: CHEBI:15347
name: acetone
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
has only substance units: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207

http://identifiers.org/biomodels.db/MODEL1310110056#_351c1a84_4b6e_4bb4_b53f_aa34f62a8a49
is: SBO:0000252
is: B7Z3K8
type: Species
initial concentration: NaN
initial amount: NaN
name: COQ6
constant: false
is encoded by: hsa:51004
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_2c74684e_5393_4f61_beb7_caddb3002db7
constant: false
is: Q8TB61
is: SBO:0000252
name: SLC35B2
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:347734
initial amount: NaN
type: Species

metaR r0139
is: SBO:0000176
reversible: true
reactant: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000000
kinetic law: MODEL1310110056#
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/2.3.2.2
type: Reaction

metaM m8mpdol U r
constant: false
type: Species
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C1725H2840N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1
is: SBO:0000247
is: CHEBI:59093

http://identifiers.org/biomodels.db/MODEL1310110056#_cd0d4013_a795_4ca8_b581_a069a5eefe51
is: SBO:0000252
type: Species
is: O95864
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
name: FADS2
is encoded by: hsa:9415
boundary condition: true

metaR S2L2N2M2MASNtly
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: s2l2n2m2masn transport, extracellular to lysosome

metaM tethex3 e
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
has only substance units: false
name: tetracosahexaenoic acid, n-3
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: HMDB02007

metaR ALASERNaEx
name: L-alanine/L-serine Na-dependent exchange (Ala-L in)
is described by: ECO:0000269
kinetic law: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
modifier: MODEL1310110056#
is: SBO:0000185
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110056#_35f8f8a4_6e02_43ab_9295_e39242d73139
initial concentration: NaN
is encoded by: hsa:122970
constant: false
name: ACOT4
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is: Q8N9L9

metaM 3decdicoa x
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: 3,7-decadienoylcoa
is: SBO:0000247
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
has only substance units: false
initial amount: NaN

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_ebeaf0ab_3f31_4bb2_830a_6345e90a2274
is encoded by: hsa:587
type: Species
has only substance units: false
boundary condition: true
name: BCAT2
is: SBO:0000252
initial concentration: NaN
constant: false
is: O15382
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_45bf40cc_cce8_44a9_a78c_8c48b58f4463
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1491
constant: false
name: CTH
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is: B4E1R2

metaR LNLNCGCRNt
is: SBO:0000185
modifier: MODEL1310110056#
product: MODEL1310110056#
name: transport into the mitochondria (carnitine)
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
type: Reaction
reversible: false

metaM carn e
initial concentration: 1.0
is: HMDB00033
is: SBO:0000247
is: CHEBI:15727
type: Species
constant: false
notes: FORMULA: C9H14N4O3 CHARGE: 0 INCHI: InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1
initial amount: NaN
name: carnosine
boundary condition: false
has only substance units: false

metaM cmp g
is: CHEBI:60377
is: HMDB00095
constant: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
name: CMP(2-)

metaM HC02121 c
type: Species
is: SBO:0000247
is: CHEBI:58758
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
constant: false
name: S-(hydroxymethyl)glutathione(1-)
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_8931d88f_9924_419e_98e8_f6cac1e55de4
initial concentration: NaN
type: Species
is encoded by: hsa:PRO1933
boundary condition: true
initial amount: NaN
name: _PRO1933_1_m
has only substance units: false
is: SBO:0000252
constant: false

metaM gly m
type: Species
constant: false
is: C00037
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
name: Glycine
is: HMDB00123
is: CHEBI:15428

metaR S23T3g
is: SBO:0000176
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
kinetic law: MODEL1310110056#
fast: false
reversible: false
is described by: ECO:0000000
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.4.99.6
type: Reaction
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
modifier: MODEL1310110056#

metaM atp x
is: HMDB00538
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:57299
initial amount: NaN
constant: false
initial concentration: 1.0
is: C00002
name: ATP(4-)

http://identifiers.org/biomodels.db/MODEL1310110056#_307fadd5_2831_49ea_8392_492d7e660d7a
boundary condition: true
initial amount: NaN
name: ADSL
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:158
initial concentration: NaN

metaM pro D e
is: CHEBI:16313
name: D-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
has only substance units: false
type: Species
constant: false
is: HMDB03411
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR r0719
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (6697.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
reactant: MODEL1310110056#
fast: false
type: Reaction
reversible: false
product: MODEL1310110056#
is described by: ECO:0000000
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.1.1.153

metaM dcholcoa c
is: HMDB06292
is: CHEBI:28701
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: chenodeoxycholoyl coenzyme a
has only substance units: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial concentration: 1.0
type: Species

metaR HSAT4ly
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
is described by: ECO:0000000
reactant: MODEL1310110056#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000185
reversible: false
fast: false

metaM tethex3 c
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB02007
is: SBO:0000247
has only substance units: false
name: tetracosahexaenoic acid, n-3
boundary condition: false
type: Species

metaR r1979
reactant: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110056#
name: Y+LAT2 Utilized transport
is: SBO:0000185
is described by: ECO:0000000
fast: false
modifier: MODEL1310110056#
reversible: false
kinetic law: MODEL1310110056#

metaM cdpdag hs c
constant: false
type: Species
is: CHEBI:58332
boundary condition: false
is: SBO:0000247
name: CDP-diacylglycerol(2-)
initial concentration: 1.0
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
initial amount: NaN
has only substance units: false

metaR EX malcoa LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: malonyl-CoA(4-) exchange
type: Reaction

metaR GLCNACASE4ly
type: Reaction
name: alpha-N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.50
is described by: ECO:0000000
fast: false
modifier: MODEL1310110056#
reversible: false
is: SBO:0000176
product: MODEL1310110056#

metaM biocyt e
type: Species
is: C05552
has only substance units: false
boundary condition: false
name: Biocytin
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/7886
is: SBO:0000247
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: HMDB03134
initial amount: NaN

metaM cmp c
is: HMDB00095
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
name: CMP
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: C00055
is: CHEBI:60377
constant: false
initial amount: NaN
type: Species

metaM co2 c
notes: FORMULA: CO2 CHARGE: 0
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: C00011
is: HMDB01967
name: CO2
is: CHEBI:3313
constant: false
initial amount: NaN
type: Species

metaR SERGLNNaEx
name: L-serine/L-glutamine Na-dependent exchange (Ser-L in)
reactant: MODEL1310110056#
is described by: ECO:0000269
modifier: MODEL1310110056#
is: SBO:0000185
kinetic law: MODEL1310110056#
fast: false
reversible: false
type: Reaction
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaM tdcoa c
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: HMDB01521
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: C02593
is: CHEBI:57385
boundary condition: false
initial concentration: 1.0
type: Species
constant: false

metaM cs e deg5 l
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C31H47NO35S3 CHARGE: -4
is: CHEBI:57737
is: SBO:0000247
is: HMDB00868
has only substance units: false

metaM co2 e
is: HMDB01967
initial concentration: 1.0
name: CO2
has only substance units: false
is: CHEBI:16526
constant: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: C00011
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM cmp e
is: CHEBI:60377
is: HMDB00095
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: CMP(2-)
boundary condition: false
is: SBO:0000247

metaM adpcoa c
is: C14143
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB04047
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
initial amount: NaN
type: Species
is: SBO:0000247
name: adipoylcoa
has only substance units: false

metaM carn c
boundary condition: false
is: HMDB00033
has only substance units: false
notes: FORMULA: C9H14N4O3 CHARGE: 0 INCHI: InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1
is: CHEBI:15727
is: SBO:0000247
initial amount: NaN
name: carnosine
type: Species
initial concentration: 1.0
constant: false

metaR LPS4e
kinetic law: MODEL1310110056#
type: Reaction
name: phospholipase
fast: false
notes: GENE_ASSOCIATION: (50487.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10713052 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
is: SBO:0000176
reactant: MODEL1310110056#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.4
modifier: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000000

metaR r1540
type: Reaction
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
reactant: MODEL1310110056#
is: SBO:0000185
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110056#_9b4c97a0_195b_4ef4_968c_72eb70098213
boundary condition: true
is encoded by: hsa:6392
name: SDHA:SDHB:SDHC:SDHD
initial amount: NaN
has part: O14521
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6389
has part: Q99643
constant: false
is encoded by: hsa:6390
has part: P31040
has part: P21912
type: Species
is: SBO:0000297
is encoded by: hsa:6391

metaM pro D c
is: CHEBI:16313
constant: false
is: HMDB03411
boundary condition: false
initial concentration: 1.0
name: D-proline
has only substance units: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: SBO:0000247
initial amount: NaN
type: Species

metaM xol7ah2 m
is: SBO:0000247
boundary condition: false
type: Species
name: 5beta-cholestane-3alpha,7alpha-diol
initial amount: NaN
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: CHEBI:28047
has only substance units: false
is: HMDB06893
constant: false
initial concentration: 1.0

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_fb3757bf_aac3_4db5_8a17_59b16c695c72
is: Q308M7
is encoded by: hsa:5169
initial concentration: NaN
boundary condition: true
type: Species
constant: false
name: ENPP3
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR THYMt
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
modifier: MODEL1310110056#
name: thymine reversible transport via facilated diffusion
fast: false
is described by: ECO:0000269
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000185
product: MODEL1310110056#
reversible: true

metaM 2docopencoa x
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
boundary condition: false
type: Species
is: SBO:0000247
constant: false
has only substance units: false
name: 2,7,10,13,16-docosapentenoylcoa
initial amount: NaN

metaM biocyt c
is: http://identifiers.org/pubchem.compound/7886
initial amount: NaN
name: Biocytin
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: HMDB03134
is: C05552
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_b2a05084_7993_432b_9095_166332388396
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:80055
is: SBO:0000252
name: PGAP1
is: Q75T13
initial amount: NaN
has only substance units: false

metaR ASNGLNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
modifier: MODEL1310110056#
reversible: false
fast: false
type: Reaction
product: MODEL1310110056#
is described by: ECO:0000269
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)

metaM tetpent6coa x
boundary condition: false
name: tetracosapentaenoyl coenzyme A, n-6
has only substance units: false
is: C16172
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
initial amount: NaN

metaR XOL7AONEtr
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
reversible: true
name: lipid, flip-flop intracellular transport
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#

metaR LEUGLYPEPT1tc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_a5f0596d_004f_4ad2_8055_8ea2e574177b
constant: false
is: Q6YFQ2
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: COX6B2
is encoded by: hsa:125965
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_2f4ec338_d420_43e9_9a15_421b316260d0
is: P38117
type: Species
is encoded by: hsa:2109
initial concentration: NaN
initial amount: NaN
name: ETFB
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false

metaM 3pg c
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: C00197
name: 3-Phospho-D-glycerate
is: CHEBI:58272
is: http://identifiers.org/pubchem.compound/3497
is: SBO:0000247
is: HMDB00807
boundary condition: false

metaM ttdca e
is: HMDB00806
name: tetradecanoate (n-C14:0)
boundary condition: false
is: CHEBI:30807
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
is: SBO:0000247
is: C06424
initial amount: NaN
has only substance units: false

metaM CE5114 x
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,20-21,28-30,34-36,40,51-52H,4-7,10,13,16-19,22-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,21-20+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE5114
constant: false
has only substance units: false
is: CHEBI:57923
initial amount: NaN
name: trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110056#_045ad76c_4bf5_4739_bc78_dfe7c093f0e0
boundary condition: true
constant: false
name: PRDX1
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:5052
initial concentration: NaN

metaR ARSA
product: MODEL1310110056#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.8
reversible: false
type: Reaction
modifier: MODEL1310110056#
name: Arylsulfatase A
reactant: MODEL1310110056#
is: SBO:0000176
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ
kinetic law: MODEL1310110056#
fast: false

metaR ENGASE3ly
is: SBO:0000176
is described by: ECO:0000000
reversible: false
name: endo-beta-N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
type: Reaction

metaR CYSGLYexR
kinetic law: MODEL1310110056#
type: Reaction
name: L-cysteine/glycine reversible exchanger
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110056#
is: SBO:0000185
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
product: MODEL1310110056#

metaM thf c
type: Species
constant: false
is: CHEBI:57453
has only substance units: false
name: 5,6,7,8-Tetrahydrofolate
is: SBO:0000247
is: C00101
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: HMDB01846
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM odecrn c
is: HMDB01114
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
is: C00412
name: octadecenoyl carnitine
is: CHEBI:57394
has only substance units: false
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1

metaR GLYPHEPEPT1tc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycylphenylalanine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaM prostgd2 r
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:57406
constant: false
type: Species
is: SBO:0000247
name: prostaglandin D2(1-)
boundary condition: false
is: HMDB01403

metaM 25hvitd3 c
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: HMDB03550
initial amount: NaN
name: calcidiol
is: CHEBI:17933
is: SBO:0000247
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1

metaR GDPtg
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
type: Reaction
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110056#
is described by: ECO:0000000
name: GDP intracellular transport
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_5cedfb5c_abbf_4395_a1c4_93d08621e352
constant: false
is: SBO:0000252
is: O75251
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:374291
initial amount: NaN
name: NDUFS7

metaM stcrn c
name: stearoylcarnitine
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00848
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM m2mpdol U c
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C1365H2240N20O320P20 CHARGE: -20
initial concentration: 1.0
is: CHEBI:28049
constant: false

metaR NAHCO3 HCLt
fast: false
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
is: SBO:0000185
modifier: MODEL1310110056#
name: bicarbonate transport (HCl/NaHCO3 exchange)
reversible: true
type: Reaction
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_6b88ab87_dc02_4d97_8fae_fb4659275842
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:7167
name: TPI1
has only substance units: false
constant: false
is: Q53HE2
initial amount: NaN
is: SBO:0000252

metaM pmtcrn x
is: HMDB00222
name: L-palmitoylcarnitine
boundary condition: false
type: Species
is: CHEBI:17490
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
constant: false

metaM amp r
is: HMDB00045
boundary condition: false
name: AMP
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: C00020
type: Species
initial amount: NaN
constant: false
is: CHEBI:456215
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020

metaR ARACHDt2
kinetic law: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
is: SBO:0000185
name: fatty acid transport via diffusion
product: MODEL1310110056#
reversible: true
fast: false
reactant: MODEL1310110056#

metaM pe hs c
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16038
type: Species
is: SBO:0000247

metaR It
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
kinetic law: MODEL1310110056#
fast: false
modifier: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000185
name: Iodide uniport
reversible: true
reactant: MODEL1310110056#
type: Reaction

metaM ttdca c
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00806
is: SBO:0000247
is: CHEBI:30807
name: myristate
boundary condition: false
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
initial amount: NaN

metaM atp r
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
name: ATP(4-)
is: C00002
boundary condition: false
constant: false
is: HMDB00538
is: CHEBI:57299

http://identifiers.org/biomodels.db/MODEL1310110056#_52d85cda_80a8_4558_9f4c_9729e6986729
type: Species
is encoded by: hsa:AI640625
initial concentration: NaN
is: SBO:0000252
constant: false
name: _AI640625_1_c
boundary condition: true
initial amount: NaN
has only substance units: false

metaM ksi deg4 l
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: keratan sulfate I, degradation product 4
is: CHEBI:57737
is: HMDB00868
type: Species
initial concentration: 1.0
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
boundary condition: false

metaR GLUNm
kinetic law: MODEL1310110056#
reversible: false
name: glutaminase (mitochondrial)
is version of: http://identifiers.org/ec-code/3.5.1.2
is described by: ECO:0000269
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (2744.1) or (27165.2) or (27165.1) SUBSYSTEM: Glutamate metabolism EC Number: 3.5.1.2 Confidence Level: 4 AUTHORS: PMID:10719215,PMID:12579526 NOTES:
reactant: MODEL1310110056#
is: SBO:0000176
product: MODEL1310110056#
fast: false
type: Reaction

metaM ksii core2 pre3 g
initial amount: NaN
is: C00130
notes: FORMULA: C47H76N4O33X CHARGE: -1
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 3
is: HMDB00175
boundary condition: false
is: CHEBI:58053
constant: false
type: Species

metaR SUBERCROT
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_efc630f6_275d_44af_a7c2_cadc5d5a7160
is: SBO:0000252
is: F5H6D0
is encoded by: hsa:7841
initial amount: NaN
name: MOGS
type: Species
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

metaR EX leugly LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylglycine
type: Reaction

metaM tetde5coa x
initial amount: NaN
name: 5-tetradecenoylcoa
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
is: HMDB13109
constant: false

metaR r1384
fast: false
reactant: MODEL1310110056#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: true
product: MODEL1310110056#
kinetic law: MODEL1310110056#
name: Guanosine aminohydrolase EC:3.5.4.15
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:

metaR GRTTx
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
fast: false
is described by: ECO:0000134
product: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.1
type: Reaction
name: geranyltranstransferase

metaM gly x
boundary condition: false
initial amount: NaN
name: glycine
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB00123
initial concentration: 1.0
is: CHEBI:15428
constant: false

metaR FRDPtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
is: SBO:0000185
name: lipid, flip-flop intracellular transport
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110056#
reversible: true

metaR PRISTCOAtcx
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

metaR r1649
reactant: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110056#
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#
reversible: true

metaM 4ppcys c
is: C04352
initial amount: NaN
type: Species
boundary condition: false
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
is: SBO:0000247
constant: false
is: CHEBI:59458
initial concentration: 1.0
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
has only substance units: false
is: HMDB01117

metaR FTHFLm
notes: GENE_ASSOCIATION: (25902.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.4.3 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
name: formate-tetrahydrofolate ligase, mitochondrial
modifier: MODEL1310110056#
reactant: MODEL1310110056#
product: MODEL1310110056#
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.3
type: Reaction
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110056#
is described by: ECO:0000269

metaM ksi deg33 l
is: CHEBI:12936
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
type: Species
initial concentration: 1.0
is: HMDB00143
name: keratan sulfate I, degradation product 33

metaM hexccoa c
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
name: Hexacosanoyl-CoA (n-C26:0CoA)
boundary condition: false
notes: FORMULA: C47H82N7O17P3S CHARGE: -4 INCHI: InChI=1/C47H86N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-38(56)75-31-30-49-37(55)28-29-50-45(59)42(58)47(2,3)33-68-74(65,66)71-73(63,64)67-32-36-41(70-72(60,61)62)40(57)46(69-36)54-35-53-39-43(48)51-34-52-44(39)54/h34-36,40-42,46,57-58H,4-33H2,1-3H3,(H,49,55)(H,50,59)(H,63,64)(H,65,66)(H2,48,51,52)(H2,60,61,62)/p-4/t36-,40-,41-,42+,46-/m1/s1
is: HMDB06459
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_a7fb14c9_4729_4988_911d_6aa160f29b31
constant: false
is: Q9Y303
name: AMDHD2
has only substance units: false
is encoded by: hsa:51005
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species

metaR PNTOte
fast: false
name: Transport of (R)-Pantothenate
is: SBO:0000185
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110056#
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_aced9b84_02a7_47e7_b7a1_eb2baf58bd3d
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is: O75874
name: IDH1
is encoded by: hsa:3417
has only substance units: false

metaR PCHOLPm hs
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.4.4
type: Reaction
is described by: ECO:0000269
product: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
name: choline phosphatase
reversible: false
reactant: MODEL1310110056#
is: SBO:0000176

metaR FAOXC61C4m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_b00b9d70_69ee_44e3_9701_cbd6f635d644
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P20933
is: SBO:0000252
name: AGA
type: Species
is encoded by: hsa:175

metaR PAIL4P HStn
fast: false
reversible: true
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)

metaR DLNLCGCPT1
fast: false
reactant: MODEL1310110056#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: false
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110056#

metaR r1648
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110056#
is: SBO:0000185
reversible: true
modifier: MODEL1310110056#
product: MODEL1310110056#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_9f970916_7201_4c81_af08_5dd3b1f428db
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: SLC25A5
is encoded by: hsa:292
boundary condition: true
type: Species
initial amount: NaN
is: Q6NVC0

metaR ACACt2
modifier: MODEL1310110056#
is: SBO:0000185
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
reversible: true
name: acetoacetate transport via proton symport

metaM HC00361 c
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:58335
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: sedoheptulose 1,7-bisphosphate(4-)
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447

http://identifiers.org/biomodels.db/MODEL1310110056#_5a7a29cc_d585_41b8_88f4_4382db50a765
type: Species
name: GALNT4
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8693
is: Q8N4A0

http://identifiers.org/biomodels.db/MODEL1310110056#_c048bcfb_a97f_4caf_839d_588e70f73fb4
name: ATG9B
is encoded by: hsa:285973
is: SBO:0000252
constant: false
type: Species
is: Q674R7
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM hdca l
initial amount: NaN
is: HMDB00220
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
type: Species
name: palmitate
constant: false
is: SBO:0000247
is: CHEBI:7896

http://identifiers.org/biomodels.db/MODEL1310110056#_5618de6b_e951_4a08_a13a_3e5ae1e8ee10
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
name: BCAT1
is: P54687
boundary condition: true
is encoded by: hsa:586
is: SBO:0000252
has only substance units: false

metaR DLNLCGCPT2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110056#
fast: false
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110056#
modifier: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
reversible: false
is: SBO:0000176

metaR RE1533M
fast: false
name: RE1533
type: Reaction
kinetic law: MODEL1310110056#
is: SBO:0000176
product: MODEL1310110056#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
modifier: MODEL1310110056#

metaR PDE1
type: Reaction
reversible: false
name: 3',5'-cyclic-nucleotide phosphodiesterase
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.35
modifier: MODEL1310110056#
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.4.17
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD

metaR r1647
reactant: MODEL1310110056#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_15e7b321_79d3_4b09_adf3_c8bc9d51ac37
is encoded by: hsa:51196
is: Q9P212
has only substance units: false
initial amount: NaN
name: PLCE1
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_08463c16_cc8d_4b6f_8ec7_410903904929
name: MGLL
is encoded by: hsa:11343
is: Q99685
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_1b111c51_9339_4eff_94c8_253da47d9926
initial amount: NaN
is encoded by: hsa:T83654
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
name: _T83654_1_e
type: Species

metaR FUMSO4tm
reversible: true
name: Fumarate:sulfate antiport, mitochondrial
reactant: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_b4f59316_12c7_43c5_a637_e610cd1f56f7
type: Species
is encoded by: hsa:1120
is: Q9Y259
name: CHKB
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_0128928c_6669_4f8b_add7_de05305420a9
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:205
has only substance units: false
constant: false
name: AK4
is: SBO:0000252
initial amount: NaN

metaR NACHEX3ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
product: MODEL1310110056#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110056#
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000176
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR r0033
reversible: false
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
kinetic law: MODEL1310110056#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
product: MODEL1310110056#
modifier: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
type: Reaction
is: SBO:0000176

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR r1646
type: Reaction
modifier: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110056#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110056#
is: SBO:0000185
kinetic law: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM gthrd e
is: CHEBI:57925
is: HMDB00125
type: Species
is: SBO:0000247
name: glutathionate(1-)
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
boundary condition: false

metaR S6TASE3ly
modifier: MODEL1310110056#
product: MODEL1310110056#
fast: false
type: Reaction
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110056#
is described by: ECO:0000000
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal

metaM 25hvitd3 e
initial amount: NaN
name: calcidiol
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17933
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1
has only substance units: false
is: HMDB03550
constant: false

metaM pa hs n
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
name: phosphatidate(2-)
type: Species
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: CHEBI:57739
has only substance units: false

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_f94c8bc2_5e58_47df_93c4_f60b56cb53ed
is: P00338
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:3939
boundary condition: true
name: LDHA
has only substance units: false
initial concentration: NaN
type: Species

metaM pristcoa c
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:51341
boundary condition: false
constant: false
name: pristanoyl coa
initial amount: NaN
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2

metaM 25hvitd3 m
type: Species
is: CHEBI:17933
is: SBO:0000247
constant: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1 EHMN_ABBREVIATION: C01561
initial amount: NaN
boundary condition: false
name: calcidiol
initial concentration: 1.0
has only substance units: false
is: HMDB03550

metaR G14T13g
is described by: ECO:0000000
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110056#
is: SBO:0000176
modifier: MODEL1310110056#
product: MODEL1310110056#

metaR PROSTGI2tr
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
type: Reaction
is described by: ECO:0000269
fast: false
name: Prostaglandin I2 transport (ER)
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110056#_296b1156_fc1a_433d_8299_080bb882e827
name: ST3GAL3
is: SBO:0000252
is: Q5T4Y1
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
is encoded by: hsa:6487

metaR C8DCc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberylcarnitine
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR PE HStm
name: phosphatidylethanolamine scramblase
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110056#
reversible: true
type: Reaction
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_7a9c5c36_8a88_4535_8667_40e0720be3c0
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:203
is: P00568
boundary condition: true
name: AK1

metaM utp c
has only substance units: false
is: CHEBI:46398
name: UTP
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00285
type: Species
constant: false
is: C00075
boundary condition: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075

metaM HC02187 e
name: reverse-triiodthyronine
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:28774
is: SBO:0000247
constant: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
has only substance units: false

metaM pa hs m
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
name: phosphatidate(2-)
type: Species
boundary condition: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
initial concentration: 1.0
is: CHEBI:57739

metaM cs c deg3 l
is: SBO:0000247
is: HMDB00127
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C31H48NO32S2 CHARGE: -3
type: Species
initial concentration: 1.0
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 3
is: CHEBI:15748
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_f0f782d9_7ff7_456c_8313_cb510f87485d
initial amount: NaN
is: Q9BV10
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: ALG12
is encoded by: hsa:79087
boundary condition: true

metaR GALASE12ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110056#
reversible: false
modifier: MODEL1310110056#
name: beta-galactosidase, lysosomal
type: Reaction
is: SBO:0000176

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaM trdrd c
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
boundary condition: false
has only substance units: false
is: C00342
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: Reduced thioredoxin
is: CHEBI:15967
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_ffe59852_72e5_4ae5_b74a_a50165c37046
boundary condition: true
name: ACP1
initial concentration: NaN
is encoded by: hsa:52
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: B5MCC7

http://identifiers.org/biomodels.db/MODEL1310110056#_47c16685_0615_48d4_a294_145607895f65
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:FLJ44968
name: _FLJ44968_1_m
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_a785f900_a03a_4b0f_bb71_ecd814a542bf
name: PLCB3
constant: false
is: SBO:0000252
initial amount: NaN
is: G5E960
is encoded by: hsa:5331
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_c88b2cfa_aae3_4b56_a37e_75dfea39f452
is: Q8TE04
initial concentration: NaN
type: Species
boundary condition: true
constant: false
name: PANK1
is encoded by: hsa:53354
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM hdca e
is: SBO:0000247
boundary condition: false
notes: FORMULA: C16H31O2 CHARGE: -1
constant: false
initial amount: NaN
is: CHEBI:0
name: Hexadecanoate (n-C16:0)
has only substance units: false
initial concentration: 1.0
is: HMDB00220
is: C00249
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_f0bc234e_caaf_4222_9420_ae4c1e6d7cf8
constant: false
is encoded by: hsa:8703
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: B4GALT3
boundary condition: true
is: A8K5Z0
type: Species

metaM 3spyr c
constant: false
is: CHEBI:57940
notes: FORMULA: C3H2O6S CHARGE: -2 INCHI: InChI=1S/C3H4O6S/c4-2(3(5)6)1-10(7,8)9/h1H2,(H,5,6)(H,7,8,9)/p-2 EHMN_ABBREVIATION: C05528
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB04045
name: 3-sulfonatopyruvate(2-)
type: Species

metaR BHBtm
is described by: ECO:0000000
kinetic law: MODEL1310110056#
product: MODEL1310110056#
fast: false
reversible: true
is: SBO:0000185
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
reactant: MODEL1310110056#

metaR r0860
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.2.27
product: MODEL1310110056#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
reversible: true
reactant: MODEL1310110056#
name: Utilized transport
modifier: MODEL1310110056#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_2ae602d7_7e0a_4ca4_8a03_38e0ca91dcc0
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is: P56181
is encoded by: hsa:4731
name: NDUFV3
boundary condition: true
constant: false
has only substance units: false

metaR OCD11COACPT1
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaM hxcoa m
is: HMDB06522
name: Hexanoyl-CoA (n-C6:0CoA)
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247

metaM bglc e
name: beta-glucans
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C1200000H2200000O1100000 CHARGE: 0
is: HMDB00725
initial amount: NaN
type: Species
has only substance units: false

metaM utp e
constant: false
initial amount: NaN
name: UTP(4-)
type: Species
is: CHEBI:46398
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: SBO:0000247
has only substance units: false
is: HMDB00285

http://identifiers.org/biomodels.db/MODEL1310110056#_1e9043fc_094a_4a67_9e27_cf4c0f71b2cf
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4907
initial amount: NaN
is: P21589
name: NT5E
type: Species
initial concentration: NaN
boundary condition: true

metaM HC02187 c
name: reverse-triiodthyronine
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:28774
is: SBO:0000247
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
constant: false

metaR 5MTHFt
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
is: SBO:0000185
is described by: ECO:0000269
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
product: MODEL1310110056#
fast: false
type: Reaction
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_bf7b4c49_0e24_4796_a8cb_7f67d44da0b8
name: GALE
is: Q38G75
type: Species
is encoded by: hsa:2582
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN

metaM dolp U c
type: Species
initial amount: NaN
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
constant: false
name: dolichyl phosphate(2-)
has only substance units: false
initial concentration: 1.0
is: CHEBI:57683
boundary condition: false
is: SBO:0000247

metaR S6T10g
kinetic law: MODEL1310110056#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
type: Reaction
product: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
reactant: MODEL1310110056#
is described by: ECO:0000000
modifier: MODEL1310110056#

metaM dhcholestanate c
has only substance units: false
constant: false
boundary condition: false
is: HMDB00359
is: SBO:0000247
is: CHEBI:16577
type: Species
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial amount: NaN
initial concentration: 1.0

metaM 7dhf e
is: HMDB06559
is: SBO:0000247
name: heptaglutamyl folate (DHF)
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_bcc8b485_caff_405b_9e29_4439478715f2
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:1109
boundary condition: true
is: P17516
name: AKR1C4

http://identifiers.org/biomodels.db/MODEL1310110056#_723633a2_4138_49ea_837a_df350bacd156
initial concentration: NaN
is encoded by: hsa:226
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: ALDOA

metaR FAOXC160
is: SBO:0000176
product: MODEL1310110056#
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reversible: false
reactant: MODEL1310110056#
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
fast: false

metaR r0408
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.4.3.5
fast: false
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
product: MODEL1310110056#
reversible: true
type: Reaction
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:

metaM atp e
is: C00002
constant: false
is: CHEBI:57299
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: ATP(4-)
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB00538

metaM tetd7ecoa m
initial amount: NaN
boundary condition: false
type: Species
constant: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
name: 7-tetradecenoylcoa
initial concentration: 1.0
is: HMDB13109
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_8379d218_d25d_4092_adee_b9672222b880
type: Species
name: NMNAT3
initial concentration: NaN
is: Q96T66
constant: false
is encoded by: hsa:349565
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaM 7dhchsterol c
initial concentration: 1.0
is: CHEBI:17759
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
name: cholesta-5,7-dien-3beta-ol
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00032
has only substance units: false
constant: false
type: Species

metaM spmd e
type: Species
name: Spermidine
has only substance units: false
is: C00315
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
initial concentration: 1.0
is: CHEBI:57834
is: HMDB01257
boundary condition: false

metaM ksii core2 pre5 g
initial concentration: 1.0
is: C00130
is: SBO:0000247
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: CHEBI:58053
is: HMDB00175
has only substance units: false
type: Species
boundary condition: false
constant: false
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 5

http://identifiers.org/biomodels.db/MODEL1310110056#_11e4c322_051d_4aaf_8c20_bebf02133171
is encoded by: hsa:11254
name: SLC6A14
is: SBO:0000252
is: Q9UN76
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true

metaR r2380
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
product: MODEL1310110056#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110056#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110056#
type: Reaction

metaR sink c101coa LPAREN c RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C101COASINK
type: Reaction

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

metaR 4MOPte
is: SBO:0000185
reactant: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
reversible: true
product: MODEL1310110056#
fast: false
is described by: ECO:0000134
name: Transport of 4-methyl-2-oxopentanoate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM hdca c
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:7896
constant: false
initial concentration: 1.0
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
boundary condition: false
is: HMDB00220
name: palmitate
has only substance units: false

metaR ACHEe
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.7
product: MODEL1310110056#
is described by: ECO:0000269
kinetic law: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
modifier: MODEL1310110056#
is: SBO:0000176
reactant: MODEL1310110056#
name: Acetylcholinesterase

metaR r1641
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110056#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110056#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM his L m
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
constant: false
name: L-histidine
boundary condition: false
is: CHEBI:15971
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00177
initial amount: NaN

metaR FAOXC81C61x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_7d5197ce_2fc5_49b3_83cd_09aebc2e9a49
initial concentration: NaN
has only substance units: false
is encoded by: hsa:26
boundary condition: true
is: SBO:0000252
constant: false
is: P19801
type: Species
initial amount: NaN
name: ABP1

http://identifiers.org/biomodels.db/MODEL1310110056#_12017f19_99b9_4f36_96f0_bc72c4401328
initial amount: NaN
name: NDUFA3
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: O95167
is: SBO:0000252
is encoded by: hsa:4696
constant: false

metaR EX tetdec2crn
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_936ea35d_9232_4f3d_b792_aeb4df31ca9d
name: PRDX2
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:7001

http://identifiers.org/biomodels.db/MODEL1310110056#_7ca85c66_e2e4_4990_8dd9_35f446381a13
initial concentration: NaN
type: Species
is encoded by: hsa:6487
initial amount: NaN
name: ST3GAL3
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q5T4W8

metaM 4ppcys m
constant: false
initial concentration: 1.0
is: CHEBI:59458
boundary condition: false
has only substance units: false
is: SBO:0000247
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
initial amount: NaN
type: Species
is: HMDB01117

metaM rbt e
is: HMDB00508
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: CHEBI:15963
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
name: D-ribitol
type: Species
boundary condition: false

metaM gpi sig r
initial amount: NaN
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: Y CHARGE: 0
type: Species
is: CHEBI:58190
is: HMDB00224

metaR r1640
modifier: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000185

metaM acrn c
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
name: O-acetylcarnitine
has only substance units: false
is: HMDB00201
initial amount: NaN
is: CHEBI:57589
initial concentration: 1.0
constant: false

metaR LNLNCAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110056#
reversible: true
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110056#
kinetic law: MODEL1310110056#
name: fatty acid transport via diffusion

metaR C101CRNe
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decenoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_de98273f_ef6b_49f3_bda8_d615c04882e2
initial amount: NaN
is encoded by: hsa:2645
has only substance units: false
boundary condition: true
type: Species
constant: false
initial concentration: NaN
name: GCK
is: SBO:0000252
is: Q53Y25

http://identifiers.org/biomodels.db/MODEL1310110056#_7e9c5b7a_0309_4838_b239_7143e7d6bb7d
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4245
type: Species
constant: false
boundary condition: true
name: MGAT1
is: P26572
initial concentration: NaN
initial amount: NaN

metaM stcrn m
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00848
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
initial concentration: 1.0
type: Species
name: stearoylcarnitine

metaM 2docopencoa m
constant: false
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
boundary condition: false
name: 2,7,10,13,16-docosapentenoylcoa
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892790
type: Species
has only substance units: false

metaM spmd c
name: Spermidine
has only substance units: false
type: Species
is: HMDB01257
is: C00315
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57834
boundary condition: false

metaR EX 3ddcrn
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

metaR N4Tg
is described by: ECO:0000000
reactant: MODEL1310110056#
name: N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus
type: Reaction
product: MODEL1310110056#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is: SBO:0000176
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_6cad80df_4155_4a3d_8fd8_2fb426ac7503
is: SBO:0000252
name: BPNT1
type: Species
boundary condition: true
is encoded by: hsa:10380
initial concentration: NaN
is: O95861
initial amount: NaN
has only substance units: false
constant: false

metaR r2382
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
product: MODEL1310110056#
is described by: ECO:0000000
reactant: MODEL1310110056#
fast: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#

metaR r2443
reversible: false
product: MODEL1310110056#
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110056#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_c2422547_31c6_4bc7_a7c7_c7a8d4c52779
constant: false
type: Species
is encoded by: hsa:6553
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q9NSW9
name: SLC9A5
boundary condition: true
is: SBO:0000252

metaR GALASE13ly
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110056#
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
fast: false
is described by: ECO:0000000
reactant: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_83e94909_b0bc_4718_802b_dfa15778f791
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is: Q99643
initial concentration: NaN
is encoded by: hsa:6391
name: SDHC
initial amount: NaN

metaR r0145
modifier: MODEL1310110056#
is described by: ECO:0000000
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.8.3.1
kinetic law: MODEL1310110056#
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
type: Reaction
product: MODEL1310110056#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
reactant: MODEL1310110056#

metaR FAOXC16C16OHm
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C16OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_56afd829_49fb_47b9_bba2_c866de1db608
constant: false
is: SBO:0000252
is encoded by: hsa:53354
has only substance units: false
boundary condition: true
initial amount: NaN
name: PANK1
type: Species
initial concentration: NaN

metaR C10DCCACT
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacoyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_ecf92309_efdb_4641_9cd8_a0692d9801e4
is encoded by: hsa:7001
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: PRDX2

metaR ACALDtm
fast: false
reversible: true
name: acetaldehyde mitochondrial diffusion
type: Reaction
product: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000000
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
is: SBO:0000185

metaR SERASNNaEx
modifier: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110056#
name: L-serine/L-asparagine Na-dependent exchange (Ser-L in)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_23b18784_89dd_49da_81bf_724f75badd31
name: GGT7
is: SBO:0000252
is encoded by: hsa:2686
initial amount: NaN
constant: false
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: A0PJJ9

metaM glx m
name: glyoxylate
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:36655
is: SBO:0000247
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
initial amount: NaN
is: HMDB00119

metaR DECDICRNe
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of decadienoyl carnitine into the extra cellular space
type: Reaction

metaM retn r
constant: false
type: Species
has only substance units: false
is: CHEBI:35291
initial concentration: 1.0
is: HMDB01852
name: all-trans-retinoate
is: SBO:0000247
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_cccf190f_5136_445c_bd0a_863550fb2391
boundary condition: true
type: Species
has only substance units: false
is: Q9Y2B2
is: SBO:0000252
constant: false
name: PIGL
is encoded by: hsa:9487
initial amount: NaN
initial concentration: NaN

metaM ksii core4 pre4 g
constant: false
initial concentration: 1.0
is: SBO:0000247
is: C00130
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 4
initial amount: NaN
type: Species
notes: FORMULA: C61H99N5O43X CHARGE: -1
has only substance units: false
is: HMDB00175
is: CHEBI:58053

metaM datp n
boundary condition: false
constant: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
type: Species
name: dATP
is: HMDB01532
has only substance units: false
is: C00131
is: SBO:0000247
initial amount: NaN
is: CHEBI:61404
initial concentration: 1.0

metaM phytcoa c
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: phytanoyl-CoA(4-)
constant: false
is: SBO:0000247
is: CHEBI:57391
boundary condition: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
is: HMDB01359
type: Species

metaR r1645
product: MODEL1310110056#
is: SBO:0000185
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110056#
is described by: ECO:0000000
kinetic law: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR ACRNtm
name: O-acetylcarnintine transport into mitochondria via diffusion
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:977593 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110056#
reversible: false
reactant: MODEL1310110056#

metaM adpcoa x
is: SBO:0000247
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
is: HMDB04047
name: adipoylcoa
is: C14143
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaM aacoa m
is: SBO:0000247
is: HMDB01484
has only substance units: false
type: Species
is: CHEBI:57286
initial amount: NaN
name: acetoacetyl-CoA(4-)
constant: false
initial concentration: 1.0
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
boundary condition: false

metaM datp m
has only substance units: false
is: C00131
initial amount: NaN
is: SBO:0000247
name: dATP
is: HMDB01532
is: CHEBI:61404
constant: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
initial concentration: 1.0
type: Species
boundary condition: false

metaR XOL7AH2tm
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
product: MODEL1310110056#
reversible: true
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
name: lipid, flip-flop intracellular transport

metaM gthrd c
is: CHEBI:57925
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
is: C00051
is: HMDB00125
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
type: Species
boundary condition: false
name: Reduced glutathione

metaM doco13ecoa c
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
boundary condition: false
name: 13-docosenoylcoa
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/24892791
initial concentration: 1.0
constant: false

metaR PGMT
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:
is described by: ECO:0000134
type: Reaction
name: phosphoglucomutase
reversible: true
is version of: http://identifiers.org/ec-code/5.4.2.2
modifier: MODEL1310110056#
is: SBO:0000176
product: MODEL1310110056#
fast: false

metaR GALASE9ly
type: Reaction
name: beta-galactosidase, lysosomal
reactant: MODEL1310110056#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110056#
fast: false

metaR r1644
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110056#
reversible: true
modifier: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR FAOXC61C4x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)x
type: Reaction

metaM HC01412 m
is: CHEBI:61405
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
name: trans-tetradec-2-enoyl-CoA(4-)
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
initial amount: NaN
type: Species

metaR FAOXC183C163Gm
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

metaM Lcyst c
constant: false
name: L-cysteate(1-)
boundary condition: false
is: CHEBI:58090
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB02757
type: Species
notes: FORMULA: C3H6NO5S CHARGE: -1 INCHI: InChI=1S/C3H7NO5S/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/p-1/t2-/m0/s1 EHMN_ABBREVIATION: C00506
initial amount: NaN

metaM strdnc c
boundary condition: false
is: HMDB06547
initial concentration: 1.0
is: C16300
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205608
name: stearidonic acid C18:4, n-3
is: SBO:0000247
type: Species
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
constant: false
initial amount: NaN

metaR S2TASE1ly
reactant: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.13
fast: false
is: SBO:0000176
modifier: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000000
name: iduronate-2-sulfatase, lysosomal

metaR PMTCOAtx
kinetic law: MODEL1310110056#
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110056#
name: fatty acid intracellular transport
reversible: true
type: Reaction
product: MODEL1310110056#

metaM 3hdcoa m
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
name: (S)-3-Hydroxydecanoyl-CoA
type: Species
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
constant: false
is: SBO:0000247

metaR GLNALANaEx
modifier: MODEL1310110056#
reactant: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000269
is: SBO:0000185
fast: false
reversible: false
type: Reaction
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_987e6715_6fc3_4e32_b5b5_2258ffc73aa2
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: PIP5K1B
type: Species
initial concentration: NaN
is encoded by: hsa:8395
boundary condition: true
is: O14986
constant: false

metaM hxcoa c
type: Species
name: Hexanoyl-CoA (n-C6:0CoA)
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
is: HMDB13130
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_622112b5_2de7_46a7_8c0a_d96c27f5cf05
initial concentration: NaN
name: DGKB
is: Q9Y6T7
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:1607
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_39b9a4b5_d66a_4f12_b355_20e6e913e8f2
has only substance units: false
name: ST3GAL3
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:6487
constant: false
is: SBO:0000252

metaR NDP8ex
product: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.6
is: SBO:0000176
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
name: nucleoside-diphosphatase (UTP), extracellular
type: Reaction
fast: false
is described by: ECO:0000269
reversible: false

metaR r1643
reactant: MODEL1310110056#
modifier: MODEL1310110056#
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110056#

metaM atp c
name: ATP(4-)
is: HMDB00538
is: SBO:0000247
is: C00002
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:30616
initial concentration: 1.0

metaR NTD6
product: MODEL1310110056#
name: 5'-nucleotidase (dAMP)
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.3.5
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_dcfc81b8_5acf_4cde_ac83_08056229f9e6
constant: false
is encoded by: hsa:2876
has only substance units: false
initial amount: NaN
type: Species
name: GPX1
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR r1538
type: Reaction
reactant: MODEL1310110056#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
fast: false
name: Anion Exchanger (AE) TCDB:2.A.31.2.8

metaR r1078
is described by: ECO:0000000
kinetic law: MODEL1310110056#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Vesicular transport
product: MODEL1310110056#
reactant: MODEL1310110056#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_85b2f04c_1286_4e2f_bc82_847e4815d7f7
is: SBO:0000252
name: CYP2C19
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: P33261
type: Species
initial concentration: NaN
is encoded by: hsa:1557

metaM dcamp c
is: HMDB00536
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
is: C03794
is: CHEBI:57567
has only substance units: false
type: Species
name: N6-(1,2-Dicarboxyethyl)-AMP
initial amount: NaN
is: SBO:0000247
constant: false

metaM HC01180 c
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-4-3(1-16-19(10,11)12)18-6(9,5(4)8)2-17-20(13,14)15/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C03785
boundary condition: false
name: D-tagatofuranose 1,6-bisphosphate(4-)
is: CHEBI:58694
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110056#_33e87621_f165_4610_ab96_247f53e8658f
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:84105
is: Q9H0N5
name: PCBD2
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR DPHMBDCm
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate decarboxylation
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212,PMID:7380842 NOTES:enzyme has not been identified yet IT
reversible: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#
fast: false
reactant: MODEL1310110056#
is described by: ECO:0000000

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_3bc89616_1cfb_4365_a5b9_cfdff1743e72
is: Q13057
is encoded by: hsa:80347
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
name: COASY
boundary condition: true
initial concentration: NaN

metaM L2aadp m
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:58672
constant: false
name: L-2-aminoadipate(1-)
has only substance units: false
is: SBO:0000247
is: HMDB00510
initial concentration: 1.0
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956

metaR ACHtn
reactant: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
type: Reaction
is: SBO:0000185
name: Acetylcholin transport, nuclear trhough pores
kinetic law: MODEL1310110056#
fast: false
reversible: true
product: MODEL1310110056#

metaR r0142
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: false
product: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
modifier: MODEL1310110056#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_3dc6bed4_48da_4335_8acd_cc7b4dc22f3e
name: MVD
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P53602
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:4597

metaR MDHm
is version of: http://identifiers.org/ec-code/1.1.1.37
modifier: MODEL1310110056#
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110056#
name: malate dehydrogenase, mitochondrial
product: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
reactant: MODEL1310110056#
type: Reaction
is: SBO:0000176

metaR r1642
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
product: MODEL1310110056#

metaR C161CRNt
kinetic law: MODEL1310110056#
reversible: false
product: MODEL1310110056#
type: Reaction
name: C161 transport into the mitochondria
reactant: MODEL1310110056#
is described by: ECO:0000000
modifier: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
fast: false

metaM rbt c
initial concentration: 1.0
is: CHEBI:15963
is: HMDB00508
is: SBO:0000247
initial amount: NaN
constant: false
name: D-ribitol
boundary condition: false
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
has only substance units: false

metaM L2aadp6sa m
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
has only substance units: false
type: Species
is: CHEBI:17917
initial concentration: 1.0
constant: false
initial amount: NaN
name: L-allysine
is: SBO:0000247
is: HMDB01263
boundary condition: false

metaM pa hs g
type: Species
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57739
name: phosphatidate(2-)
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_9a04bacb_d550_4c2f_9889_f17311856a04
type: Species
name: PPCS
boundary condition: true
is encoded by: hsa:79717
is: Q9HAB8
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM strdnc e
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: HMDB06547
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205608
is: C16300
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: stearidonic acid C18:4, n-3

http://identifiers.org/biomodels.db/MODEL1310110056#_f3d0c6d6_5d03_472b_ab64_6d2a807cc024
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: DEGS1
is encoded by: hsa:8560
type: Species
has only substance units: false
constant: false

metaM glyc e
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
name: Glycerol
is: SBO:0000247
is: CHEBI:17754
initial amount: NaN
type: Species
is: C00116
is: HMDB00131
has only substance units: false

metaR FAOXC10C10OHm
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->OHC10)m
type: Reaction

metaM nh4 m
initial concentration: 1.0
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: CHEBI:28938
name: Ammonium
has only substance units: false
is: C01342
initial amount: NaN
boundary condition: false
is: HMDB00051
constant: false
type: Species
is: SBO:0000247

metaR EX ptdca LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentadecanoate exchange
type: Reaction

metaR r2375
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110056#
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110056#
type: Reaction
is: SBO:0000185

metaM ribflv e
is: C00255
name: Riboflavin
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C17H20N4O6 CHARGE: 0
initial concentration: 1.0
boundary condition: false
is: HMDB00244
constant: false
is: CHEBI:3554

metaR F1PGT
name: fucose-1-phosphate guanylyltransferase
product: MODEL1310110056#
modifier: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110056#
type: Reaction
fast: false
reactant: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.30

http://identifiers.org/biomodels.db/MODEL1310110056#_535df40b_d1af_4412_9fa4_278d31cf35c3
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:23539
name: SLC16A8
is: O95907

metaM his L c
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:15971
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
initial concentration: 1.0
boundary condition: false
name: L-histidine
is: HMDB00177

http://identifiers.org/biomodels.db/MODEL1310110056#_e210f594_19a3_435d_a234_e5a55fb11b6f
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
name: MTHFD2
is: SBO:0000252
type: Species
is: P13995
is encoded by: hsa:10797
boundary condition: true

metaM HC01602 c
type: Species
is: CHEBI:57454
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
name: 10-Formyltetrahydrofolate
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: C00234
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_0defbdc2_44dd_4cd3_854a_8fe1a81f70e7
is encoded by: hsa:6584
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
constant: false
has only substance units: false
is: O76082
name: SLC22A5
initial concentration: NaN

metaM m1mpdol U c
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247
notes: FORMULA: C1305H2140N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
initial amount: NaN
type: Species
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:28067
initial concentration: 1.0

metaM 3aib D c
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
is: C03265
name: D-3-Amino-isobutanoate
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
initial amount: NaN
is: HMDB02299
boundary condition: false

metaM fdp c
is: SBO:0000247
constant: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
is: HMDB01058
name: D-Fructose 1,6-bisphosphate
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/3647
is: CHEBI:16905
is: C00354

metaR FACOAL2251
reactant: MODEL1310110056#
is described by: ECO:0000000
fast: false
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110056#
reversible: true
product: MODEL1310110056#
modifier: MODEL1310110056#
is: SBO:0000176
type: Reaction

metaR r2003
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110056#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110056#
product: MODEL1310110056#

metaM nh4 n
is: SBO:0000247
is: CHEBI:28938
boundary condition: false
initial amount: NaN
name: ammonium
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
has only substance units: false
constant: false
type: Species
initial concentration: 1.0

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaM lpam m
boundary condition: false
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
is: HMDB00962
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:17460
name: lipoamide
constant: false

metaM chlstol r
name: 5alpha-cholesta-7,24-dien-3beta-ol
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
is: CHEBI:16290
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
initial amount: NaN
is: HMDB06842
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_7d296463_b2a9_4ded_a823_47ce38a7caf3
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:R39999
name: _R39999_1_c
constant: false

metaR r2376
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110056#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110056#
type: Reaction
product: MODEL1310110056#

metaR RE2974N
reversible: true
is described by: ECO:0000000
name: RE2974
is: SBO:0000176
type: Reaction
reactant: MODEL1310110056#
product: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
fast: false

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaM pristcoa x
name: pristanoyl coa
constant: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:51341
type: Species
boundary condition: false
is: SBO:0000247

metaM arachdcrn c
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:57387
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: SBO:0000247
name: C20:4 carnitine
is: HMDB01322

metaR EX hestratriol LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4,17 dihydroxy estradiol exchange
type: Reaction

metaR S6TASE8ly
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: true
modifier: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110056#
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR CARPEPT1tc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Carnosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR NACHEXA22ly
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reversible: false
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110056#
name: beta-N-acetylhexosaminidase A, lysosomal
is: SBO:0000176
type: Reaction
product: MODEL1310110056#
is described by: ECO:0000000
fast: false

metaR MANtly
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reversible: false
type: Reaction
kinetic law: MODEL1310110056#
product: MODEL1310110056#
name: mannose efflux from lysosome
is described by: ECO:0000000
fast: false
reactant: MODEL1310110056#

metaR r2377
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110056#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reactant: MODEL1310110056#
product: MODEL1310110056#

metaM thr L c
constant: false
is: SBO:0000247
is: CHEBI:16857
initial concentration: 1.0
boundary condition: false
type: Species
name: L-threonine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: HMDB00167
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_35350d22_45dd_445c_b027_4be7875688d9
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: DBT:DLD:BCKDHA:BCKDHB
has only substance units: false
boundary condition: true
has part: Q9BQL0
is encoded by: hsa:594
is: SBO:0000297

metaR FAOXC102C81m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

metaR AGTim
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.44
reactant: MODEL1310110056#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
product: MODEL1310110056#

metaR FUCtly
product: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
name: L-fucose efflux from lysosome
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000185

metaR PHACCOAGLNAC
reversible: false
product: MODEL1310110056#
is: SBO:0000176
reactant: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
fast: false
kinetic law: MODEL1310110056#

metaM 2dp6mep m
has only substance units: false
is: CHEBI:50774
initial concentration: 1.0
constant: false
name: 2-Decaprenyl-6-methoxyphenol
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C57H88O2 CHARGE: 0 INCHI: InChI=1S/C57H88O2/c1-45(2)23-13-24-46(3)25-14-26-47(4)27-15-28-48(5)29-16-30-49(6)31-17-32-50(7)33-18-34-51(8)35-19-36-52(9)37-20-38-53(10)39-21-40-54(11)43-44-55-41-22-42-56(59-12)57(55)58/h22-23,25,27,29,31,33,35,37,39,41-43,58H,13-21,24,26,28,30,32,34,36,38,40,44H2,1-12H3/b46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+,54-43+

http://identifiers.org/biomodels.db/MODEL1310110056#_c0d7f4e7_d9d5_4116_9e6c_69b40dddaa28
is encoded by: hsa:AI924226
is: SBO:0000252
name: _AI924226_1_m
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN

metaR r2378
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
product: MODEL1310110056#

metaM 4mzym int2 r
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: HMDB06838
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
name: 4-Methylzymosterol intermediate 2
boundary condition: false

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_f4d95b65_06fb_4d0e_8c53_849f70a1ef39
initial amount: NaN
constant: false
is encoded by: hsa:5277
has part: B2RAU6
is encoded by: hsa:9091
is encoded by: hsa:51227
is: SBO:0000297
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5279
has part: P57054
boundary condition: true
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
type: Species

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_d65615fd_ff3f_40a5_bccf_da3f5481f2fa
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
name: _R33828_1_c
is encoded by: hsa:R33828

metaM dolp U r
initial concentration: 1.0
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
name: dolichyl phosphate(2-)
has only substance units: false
is: CHEBI:57683
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN

metaM HC01414 x
name: trans-dec-2-enoyl-CoA(4-)
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:61406
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h10-11,18-20,24-26,30,41-42H,4-9,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b11-10+/t20-,24-,25-,26+,30-/m1/s1 EHMN_ABBREVIATION: C05275

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaR ACNAMPH
reactant: MODEL1310110056#
type: Reaction
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110056#
product: MODEL1310110056#
fast: false
name: N-Acetylneuraminate 9-phosphate phosphohydrolase
is: SBO:0000176

metaR TTDCAtr
product: MODEL1310110056#
fast: false
is: SBO:0000185
name: tetradecanoate (transport)
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110056#
is described by: ECO:0000269

metaM 9 cis retfa e
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: fatty acid 9-cis-retinol
type: Species
constant: false
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
is: HMDB06559
initial amount: NaN

metaM acrn x
boundary condition: false
name: O-acetylcarnitine
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: CHEBI:57589
is: SBO:0000247
is: HMDB00201
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_0ad4d3fd_1a05_455e_8486_a9df3bf96786
is: Q15735
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
name: INPP5J
is: SBO:0000252
is encoded by: hsa:27124
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_72ac8359_2421_4810_a59e_5a26af8fb33a
initial concentration: NaN
is: SBO:0000252
is: P35475
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:3425
name: IDUA

metaR r0706
modifier: MODEL1310110056#
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.3.99.10
is described by: ECO:0000000
kinetic law: MODEL1310110056#
reversible: false
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
fast: false
is: SBO:0000176
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110056#_dbd23b75_3872_47d0_9e22_ff12c4bf5a4e
is: Q99798
has only substance units: false
initial amount: NaN
name: ACO2
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:50
constant: false
is: SBO:0000252

metaM L2aadp6sa c
name: L-allysine
is: HMDB01263
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:17917
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false

metaR G16MT U
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
name: Glycolipid 1,6-alpha-D-mannosyltransferase (uterus)
reversible: false
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
fast: false
is: SBO:0000176
is described by: ECO:0000000

metaR PROSTGE2t
kinetic law: MODEL1310110056#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
type: Reaction
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reversible: true
name: prostaglandin transport via bicarbonate countertransport

metaR EX 11 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 11-cis-retinol exchange
type: Reaction

metaM L2aadp c
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
name: L-2-aminoadipate(1-)
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:58672
type: Species
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00510

metaR r2372
reactant: MODEL1310110056#
product: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaM tridcoa m
name: tridecanoylcoa
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB13109
notes: FORMULA: C34H56N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110056#_05d1f41d_5b95_475a_9625_436b5d990cf7
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: SLC16A2
is: P36021
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6567

metaR RE2996X
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.34
reactant: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: (26063.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110056#
product: MODEL1310110056#
modifier: MODEL1310110056#
name: RE2996
fast: false

metaM cs c deg4 l
is: SBO:0000247
is: HMDB00812
notes: FORMULA: C31H49NO29S CHARGE: -2
has only substance units: false
type: Species
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 4
is: CHEBI:16953
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_4eab93e7_5024_4aed_abf7_14b4e88a0a45
has only substance units: false
is: Q96CA6
is encoded by: hsa:30
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
name: ACAA1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_3f4daa7c_612d_49ee_a95c_f558474815ca
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: O60909
is encoded by: hsa:8704
name: B4GALT2
type: Species
initial concentration: NaN
is: SBO:0000252

metaM hs deg9 l
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:27491
boundary condition: false
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
name: heparan sulfate, degradation product 9
is: HMDB06465

http://identifiers.org/biomodels.db/MODEL1310110056#_610d5f91_d818_45ea_9290_82ceb82614fc
constant: false
boundary condition: true
name: ACHE
initial amount: NaN
is encoded by: hsa:43
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_4660eef2_ad97_436b_b9bf_fde4307c3081
name: _2544_1_c
constant: false
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2544

http://identifiers.org/biomodels.db/MODEL1310110056#_2dc17e33_d74c_442c_8c72_9d724526e434
has only substance units: false
is: SBO:0000252
is: Q6FG42
is encoded by: hsa:4701
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
name: NDUFA7
type: Species

metaR FAOXC2051843m
is: SBO:0000176
reversible: false
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
kinetic law: MODEL1310110056#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110056#
fast: false
name: Beta oxidation of fatty acid
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaM 3hdcoa c
name: (S)-3-Hydroxydecanoyl-CoA
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB13325

metaM datp c
name: dATP
boundary condition: false
is: CHEBI:61404
initial amount: NaN
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: HMDB01532
is: C00131
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR r2373
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110056#
product: MODEL1310110056#
reversible: true
kinetic law: MODEL1310110056#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185

metaR BTNPLm
kinetic law: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
is described by: ECO:0000000
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
type: Reaction
reactant: MODEL1310110056#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.10
modifier: MODEL1310110056#
reversible: false

metaM ksii core2 pre4 g
type: Species
constant: false
is: CHEBI:58053
initial concentration: 1.0
is: HMDB00175
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 4
notes: FORMULA: C53H86N4O38X CHARGE: -1
is: C00130
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaM ribflv c
notes: FORMULA: C17H20N4O6 CHARGE: 0
type: Species
is: C00255
initial concentration: 1.0
constant: false
name: Riboflavin
initial amount: NaN
has only substance units: false
is: HMDB00244
is: CHEBI:3554
is: SBO:0000247
boundary condition: false

metaR FACOAL2252
reactant: MODEL1310110056#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110056#
name: fatty-acid--CoA ligase
is: SBO:0000176
kinetic law: MODEL1310110056#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110056#

metaM glyc c
constant: false
name: Glycerol
is: SBO:0000247
is: CHEBI:17754
is: HMDB00131
initial amount: NaN
boundary condition: false
has only substance units: false
is: C00116
initial concentration: 1.0
type: Species
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116

http://identifiers.org/biomodels.db/MODEL1310110056#_e48ff08d_8344_49e9_8438_0c4d4d9404ef
name: COX7B2
boundary condition: true
constant: false
initial amount: NaN
is: Q8TF08
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:170712
type: Species

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_d84a6cf1_d424_4781_a0e9_c3cb2eaff359
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q11203
is encoded by: hsa:6487
constant: false
type: Species
is: SBO:0000252
name: ST3GAL3
has only substance units: false

metaM HC01412 x
boundary condition: false
is: SBO:0000247
is: CHEBI:61405
initial amount: NaN
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
has only substance units: false
name: trans-tetradec-2-enoyl-CoA(4-)
initial concentration: 1.0
type: Species
constant: false

metaR GLNCYSNaEx
product: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110056#
is: SBO:0000185
reversible: false
name: L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)
type: Reaction

metaR 34HPLFM
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
kinetic law: MODEL1310110056#
reversible: false
type: Reaction
name: 3-(4-hydroxyphenyl-)lactate formation
fast: false
product: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110056#

metaM his L e
is: HMDB00177
initial concentration: 1.0
name: L-histidine
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:15971
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
constant: false
initial amount: NaN

metaR DPPS
product: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 2 AUTHORS: PMID:16262699 NOTES:by analogy to other dimethyl transferase rxns. See PMID: 10586494, human interemidate (from C15 ->C50) not explicitly determined yet, however it is known to occur since this pathway is essential in Q10 synthesis. For human metabolism: may be associated w/ GeneID: 23590 TPRT - recheck lit in future IT and NJ
reversible: false
fast: false
reactant: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
name: decaprenyl synthase

http://identifiers.org/biomodels.db/MODEL1310110056#_59c48cc6_901b_4902_8378_550c25b534c0
boundary condition: true
has only substance units: false
is encoded by: hsa:6487
initial amount: NaN
type: Species
initial concentration: NaN
name: ST3GAL3
is: SBO:0000252
constant: false

metaR r2374
product: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110056#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_b48d8e90_de23_45e9_98aa_1ba0305b4e3c
initial concentration: NaN
name: VNN2
initial amount: NaN
boundary condition: true
is encoded by: hsa:8875
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is: A8K7W0

metaR TETDECE1CRNe
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tetradecenoyl carnitine into extra cellular space
type: Reaction

metaR LDH L
type: Reaction
reactant: MODEL1310110056#
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
is version of: http://identifiers.org/ec-code/1.1.1.27
is described by: ECO:0000000
product: MODEL1310110056#
is: SBO:0000176
fast: false
name: L-lactate dehydrogenase
reversible: true
kinetic law: MODEL1310110056#

metaM dcholcoa x
type: Species
boundary condition: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: HMDB06292
initial amount: NaN
constant: false
has only substance units: false
name: chenodeoxycholoyl coenzyme a
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28701

http://identifiers.org/biomodels.db/MODEL1310110056#_7976573c_6534_4e6b_94d2_e113881a2dbb
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: PCK2
is: Q16822
type: Species
is encoded by: hsa:5106
constant: false

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaR EX 3hexdcrn
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecanoyl carnitine
type: Reaction

metaR r0149
is described by: ECO:0000000
modifier: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reversible: true
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.39
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_8643f2e2_2b86_494e_a643_78ab8ec5900e
boundary condition: true
initial amount: NaN
is encoded by: hsa:6579
type: Species
initial concentration: NaN
name: SLCO1A2
is: P46721
has only substance units: false
constant: false
is: SBO:0000252

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaM etfox m
is: CHEBI:16469
initial concentration: 1.0
is: SBO:0000247
name: Electron transfer flavoprotein oxidized
type: Species
is: HMDB00151
notes: FORMULA: R CHARGE: 0
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_86dcdb80_e221_4a52_9460_98c3284911b2
constant: false
is encoded by: hsa:84720
initial amount: NaN
name: PIGO
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR MTHFDm
fast: false
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000176
product: MODEL1310110056#
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.4.9
is version of: http://identifiers.org/ec-code/6.3.4.3
reversible: true

metaM retn c
initial concentration: 1.0
name: all-trans-retinoate
constant: false
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: HMDB01852
has only substance units: false
is: CHEBI:35291
is: SBO:0000247

metaR CSEPASEly
fast: false
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
reactant: MODEL1310110056#
is: SBO:0000176
kinetic law: MODEL1310110056#
reversible: false
type: Reaction
is described by: ECO:0000000

metaR r0308
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
reactant: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000000
product: MODEL1310110056#
type: Reaction
reversible: false
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_f42f9f92_6717_49fb_bb51_16be3f162efb
has only substance units: false
constant: false
type: Species
is encoded by: hsa:9435
initial concentration: NaN
is: SBO:0000252
name: CHST2
initial amount: NaN
is: Q9Y4C5
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_563af409_e09c_4dd2_aac6_9ecb80b826d9
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:123041
name: SLC24A4
type: Species
initial amount: NaN

metaM doco13ecoa x
name: 13-docosenoylcoa
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892791
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C43H72N7O17P3S CHARGE: -4

metaM c81coa c
is: HMDB03949
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: octenoylcoa
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
is: C05276

metaR FAOXC102C81x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)x
type: Reaction

metaM glyc m
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:17754
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
name: Glycerol
initial amount: NaN
initial concentration: 1.0
is: C00116
type: Species
is: HMDB00131

metaR LNELDCCRNt
type: Reaction
kinetic law: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110056#
name: transport into the mitochondria (carnitine)
is described by: ECO:0000000
is: SBO:0000185
reversible: false
modifier: MODEL1310110056#
reactant: MODEL1310110056#

metaR GluForTx
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.1.2.5
reversible: false
kinetic law: MODEL1310110056#
name: Glutamate formimidoyltransferase
reactant: MODEL1310110056#
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
is described by: ECO:0000269
product: MODEL1310110056#

metaM phytcoa x
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
boundary condition: false
is: CHEBI:57391
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB01359
initial amount: NaN
name: phytanoyl-CoA(4-)
has only substance units: false
constant: false

metaR S23T4g
kinetic law: MODEL1310110056#
name: beta-galactoside alpha-2,3-sialyltransferase
type: Reaction
reactant: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110056#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.99.4
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110056#_824d0cff_177c_4840_bc8d_ea86ce164793
boundary condition: true
is: P08842
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:412
has only substance units: false
name: STS
initial concentration: NaN

metaM q10h2 m
type: Species
is: SBO:0000247
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
constant: false
is: http://identifiers.org/pubchem.compound/6504740
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: Ubiquinol-10
is: HMDB13111

http://identifiers.org/biomodels.db/MODEL1310110056#_ff8cfe3b_61fa_41e1_b1e0_76a0488e97bd
is encoded by: hsa:5151
name: PDE8A
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: true

metaM 3aib D m
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
constant: false
is: C03265
boundary condition: false
type: Species
is: HMDB02299
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: D-3-Amino-isobutanoate

metaM CE5116 x
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,19-20,28-30,34-36,40,51-52H,4-7,10,13,16-18,21-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,20-19+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE5116
is: CHEBI:57923
boundary condition: false
initial amount: NaN
has only substance units: false
name: trans-3-cis-8,11,14-eicosatetraenoyl-CoA

metaR ADPACDAc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of adipic acid for formation of adipoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_16b21cbb_6cdc_4538_9066_c8c9ef2bc29d
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: P19961
name: AMY2B
type: Species
is encoded by: hsa:280

http://identifiers.org/biomodels.db/MODEL1310110056#_7777b25a_95c5_4c23_a2d9_0bd840d14030
is: SBO:0000252
is: P14618
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:5315
name: PKM2
initial amount: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_e2d66264_7fab_4093_933a_656b23204efc
has only substance units: false
is encoded by: hsa:10400
type: Species
constant: false
name: PEMT
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR L LACt2r
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
type: Reaction
product: MODEL1310110056#
modifier: MODEL1310110056#
is: SBO:0000185
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
name: L-lactate reversible transport via proton symport
fast: false
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110056#_36351994_7b92_4aa2_8b31_5d3a378bb22c
boundary condition: true
has only substance units: false
constant: false
type: Species
name: ACSL6
is encoded by: hsa:23305
is: B2RB13
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_2d0b8b1d_6678_428c_9dcc_7efc9b246292
is encoded by: hsa:2875
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: P24298
initial amount: NaN
constant: false
type: Species
name: GPT
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_243e73af_43c2_499f_9db2_6cbaac31c8ea
initial concentration: NaN
is: SBO:0000252
is: Q9ULD0
name: OGDHL
is encoded by: hsa:55753
boundary condition: true
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaR ARACHCOAtx
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
name: fatty acid intracellular transport
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_5a1d3bf7_523c_4bf7_8351_588f51198f8f
name: SLC7A9
is encoded by: hsa:11136
initial concentration: NaN
constant: false
boundary condition: true
is: P82251
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaR LEUt5m
reversible: true
name: leucine mitochondrial transport
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_51bae532_f2c1_4918_b829_8e7c9b8006af
is encoded by: hsa:1666
name: DECR1
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q16698
constant: false
initial concentration: NaN
type: Species

metaR FAOXC3DC
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: malonylcoa-->malonylcarnitine
type: Reaction

metaM gthrd m
boundary condition: false
is: HMDB00125
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:57925
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
name: glutathionate(1-)
constant: false
type: Species

metaM nadp x
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate
is: CHEBI:58349
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: HMDB00217
initial concentration: 1.0
has only substance units: false
type: Species
is: C00006

http://identifiers.org/biomodels.db/MODEL1310110056#_ebce2546_94f8_44be_8727_69d959bfdf17
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
name: NDUFB5
type: Species
is encoded by: hsa:4711
is: SBO:0000252
is: O43674

http://identifiers.org/biomodels.db/MODEL1310110056#_0c109c97_1049_4bf0_b7bf_a27ef1e05ac7
is: Q8WUM9
boundary condition: true
name: SLC20A1
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:6574

metaM acrn r
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
constant: false
initial amount: NaN
name: O-acetylcarnitine
is: CHEBI:57589
type: Species
is: SBO:0000247
is: HMDB00201

metaM HC02202 c
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
name: prostaglandin A1(1-)
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: CHEBI:57398

metaR r0707
is: SBO:0000176
reversible: true
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate phosphohydrolase (alkaline optimum) Folate biosynthesis EC:3.1.3.1
is version of: http://identifiers.org/ec-code/2.3.1.168
product: MODEL1310110056#
fast: false
modifier: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777 NOTES:

metaR RE3301C
product: MODEL1310110056#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.4.4
modifier: MODEL1310110056#
name: RE3301
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
reversible: true
fast: false
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_d0a00912_a44c_4e1f_b16b_070ffa84288d
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P09417
name: QDPR
is encoded by: hsa:5860
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_8f26ccca_b1ba_418b_afc7_3ccd4b3e863e
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:AI761708
boundary condition: true
has only substance units: false
name: _AI761708_1_m
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_d7aa2752_8a39_426b_be6f_03b146299154
has only substance units: false
is encoded by: hsa:6005
is: Q96E98
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
name: RHAG

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaM HC00460 c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
boundary condition: false
has only substance units: false
name: 2,5-dihydroxybenzoate
is: CHEBI:58044
constant: false
type: Species

metaR r2379
product: MODEL1310110056#
reversible: true
reactant: MODEL1310110056#
is described by: ECO:0000000
type: Reaction
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110056#

metaR EX s2l2n2m2masn LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: de-Fuc form of PA6 exchange
type: Reaction

metaR ODECOAtx
kinetic law: MODEL1310110056#
type: Reaction
name: fatty acid intracellular transport
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110056#

metaR DOLPMT3 Uer
product: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.260
modifier: MODEL1310110056#
fast: false
reversible: false
reactant: MODEL1310110056#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110056#_e909cee2_d967_4ea5_9946_6049fc1bcbbc
type: Species
name: IDH2
is: P48735
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:3418

metaM ksii core4 pre5 g
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 5
has only substance units: false
constant: false
is: CHEBI:58053
boundary condition: false
notes: FORMULA: C69H112N6O48X CHARGE: -1
is: HMDB00175
is: C00130
is: SBO:0000247
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_6390e77a_3cb1_4116_b7be_a20fe4553c56
is: P53794
type: Species
has only substance units: false
is: SBO:0000252
constant: false
name: SLC5A3
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6526
initial amount: NaN

metaM HC00250 c
boundary condition: false
name: hydrosulfide
has only substance units: false
is: CHEBI:29919
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN

metaR ALAt2r
reversible: true
fast: false
name: L-alanine reversible transport via proton symport
reactant: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110056#
is: SBO:0000185
modifier: MODEL1310110056#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110056#_33960335_900f_4ee7_ab4a_d0259b08f2e4
constant: false
is: Q5JPH6
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:124454
is: SBO:0000252
name: EARS2
type: Species
has only substance units: false

metaM acgal1p c
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:55404
has only substance units: false
type: Species
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
is: HMDB06480
initial amount: NaN
name: N-Acetyl-D-galactosamine 1-phosphate
initial concentration: 1.0

metaM cs c l
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
is: SBO:0000247
initial amount: NaN
is: CHEBI:36005
initial concentration: 1.0
has only substance units: false
type: Species
name: chondroitin sulfate C (GalNAc6S-GlcA), free chain
constant: false
is: HMDB02183
boundary condition: false

metaM oh1 e
is: HMDB01039
is: SBO:0000247
initial concentration: 1.0
name: hydroxide ion
initial amount: NaN
has only substance units: false
notes: FORMULA: HO CHARGE: -1
is: C01328
boundary condition: false
constant: false
type: Species

metaM sebacid c
initial concentration: 1.0
is: SBO:0000247
name: sebacicacid
is: C08277
is: HMDB00792
notes: FORMULA: C10H16O4 CHARGE: -2
type: Species
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false

metaM pail3p hs n
initial amount: NaN
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:58088

metaR FAOXC161C141m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:1-->C14:1)m
type: Reaction

metaR HDCAtr
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
reversible: true
product: MODEL1310110056#
reactant: MODEL1310110056#
name: fatty acid transport via diffusion
fast: false
kinetic law: MODEL1310110056#
is described by: ECO:0000000

metaM HC02202 e
type: Species
name: prostaglandin A1(1-)
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:57398
initial amount: NaN

metaR OCD11CRNCACT
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaM retn e
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:35291
is: HMDB01852
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
name: all-trans-retinoate

metaM acrn m
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
constant: false
is: CHEBI:57589
is: SBO:0000247
boundary condition: false
name: O-acetylcarnitine
type: Species
initial concentration: 1.0
is: HMDB00201

metaR TRPt
name: L-tryptophan transport
is described by: ECO:0000269
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
reactant: MODEL1310110056#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110056#_64d26ff5_fa89_4821_9c99_69542fc60065
constant: false
initial amount: NaN
name: ETFB
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2109

metaM nh4 x
initial amount: NaN
constant: false
is: HMDB00051
type: Species
name: Ammonium
boundary condition: false
is: SBO:0000247
has only substance units: false
is: C01342
initial concentration: 1.0
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

http://identifiers.org/biomodels.db/MODEL1310110056#_40871f41_e72c_45e4_b850_7f5358c3f07d
name: PHPT1
is: Q9P019
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:29085
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252

metaM 1p3h5c c
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:6151
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: HMDB01369

http://identifiers.org/biomodels.db/MODEL1310110056#_c920fd3f_ad13_4281_8b17_5ac70d81a669
is: Q9UF12
is encoded by: hsa:58510
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: PRODH2
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_9f41ced8_f3aa_44c1_ae99_601b4f2e7139
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:6560
constant: false
type: Species
is: F5H066
name: SLC12A4

metaM c101coa c
is: SBO:0000247
initial concentration: 1.0
type: Species
is: C14143
name: decenoylcoa
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB04047

metaR CRNtim
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is: SBO:0000185
product: MODEL1310110056#
type: Reaction
is described by: ECO:0000269
name: L-carnitine transport out of mitochondria via diffusion
reactant: MODEL1310110056#
fast: false

metaR r1986
fast: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110056#
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_eb316ce7_0a59_4d00_958d_7f98811b0611
has only substance units: false
name: PIK3C2B
type: Species
boundary condition: true
initial amount: NaN
is: O00750
is encoded by: hsa:5287
is: SBO:0000252
constant: false
initial concentration: NaN

metaR FAOXC81C61m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

metaM HC00250 e
has only substance units: false
type: Species
constant: false
is: CHEBI:29919
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: hydrosulfide

metaR C6DCCACT
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of adipoyl carnitine into cytosol
type: Reaction

metaR SMS
is version of: http://identifiers.org/ec-code/2.7.8.27
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110056#
fast: false
reactant: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
modifier: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000269
name: Sphingomyelin synthase (homo sapiens)

metaR RNDR1
product: MODEL1310110056#
reversible: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000254
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
modifier: MODEL1310110056#
reactant: MODEL1310110056#
name: ribonucleoside-diphosphate reductase (ADP)

metaM HC02206 e
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:57399
boundary condition: false
initial amount: NaN
name: prostaglandin C1(1-)
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110056#_5e8df3a5_39b2_48d3_b95e_8055fd70a562
is: Q6IBE6
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:6484
boundary condition: true
has only substance units: false
name: ST3GAL4
initial amount: NaN

metaM oh1 c
name: hydroxide ion
has only substance units: false
initial concentration: 1.0
is: HMDB01039
is: SBO:0000247
notes: FORMULA: HO CHARGE: -1
initial amount: NaN
boundary condition: false
is: C01328
constant: false
type: Species

metaM arachdcrn m
initial amount: NaN
boundary condition: false
is: CHEBI:57387
type: Species
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: HMDB01322
initial concentration: 1.0
constant: false
name: C20:4 carnitine
has only substance units: false
is: SBO:0000247

metaM gthrd r
has only substance units: false
boundary condition: false
is: CHEBI:57925
is: HMDB00125
is: SBO:0000247
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
name: glutathionate(1-)
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0

metaR r0410
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is: SBO:0000176
product: MODEL1310110056#
reversible: true
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19

metaM but e
name: butyrate
type: Species
constant: false
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00039
is: CHEBI:17968

http://identifiers.org/biomodels.db/MODEL1310110056#_17c7673e_604a_49cd_afb0_54a2cc63a9c9
has only substance units: false
is encoded by: hsa:114
type: Species
boundary condition: true
initial concentration: NaN
is: Q4F7X0
name: ADCY8
constant: false
initial amount: NaN
is: SBO:0000252

metaM 3hodcoa c
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
constant: false
boundary condition: false
initial amount: NaN
is: HMDB13336
type: Species
name: (S)-3-Hydroxyoctadecanoyl-CoA
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM HC02179 e
is: SBO:0000247
initial concentration: 1.0
constant: false
name: 20-hydroxy-arachidonate
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:34306
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748

metaR G14T12g
reactant: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110056#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110056#

metaM 3hmp m
is: SBO:0000247
initial concentration: 1.0
is: HMDB00023
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
boundary condition: false
name: 3-hydroxy-2-methylpropanoate
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:11805
constant: false

metaR PRO Dtde
type: Reaction
product: MODEL1310110056#
fast: false
is described by: ECO:0000134
name: D-proline transport, extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
is: SBO:0000185
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: true

metaR 3MOBte
reactant: MODEL1310110056#
fast: false
product: MODEL1310110056#
kinetic law: MODEL1310110056#
name: Transport of 3-methyl-2-oxobutanoate
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR RDH3
fast: false
name: retinol dehydrogenase (11-cis,NADH)
product: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.1.1.315
reversible: true

metaM 1pyr5c m
is: HMDB01301
has only substance units: false
initial amount: NaN
is: CHEBI:15893
name: 1-Pyrroline-5-carboxylate
is: SBO:0000247
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: C03912

metaR SRTNt6 2 r
reactant: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
reversible: true
kinetic law: MODEL1310110056#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110056#
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
is described by: ECO:0000269

metaR ASNCYSNaEx
fast: false
is described by: ECO:0000269
reversible: false
product: MODEL1310110056#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaM imp e
name: IMP(2-)
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00175
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:58053

metaM ksi pre35 g
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
boundary condition: false
constant: false
type: Species
is: CHEBI:28067
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 35

metaM dpcoa e
is: SBO:0000247
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
constant: false
is: C00882
has only substance units: false
type: Species
name: Dephospho-CoA
is: CHEBI:57328
boundary condition: false
initial amount: NaN
is: HMDB01373
initial concentration: 1.0

metaM HC01401 x
name: (S)-3-Hydroxydodecanoyl-CoA
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
is: CHEBI:27668
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_9e010c7c_3e69_40fe_897e_8b07c708c490
initial concentration: NaN
has only substance units: false
is: Q86T14
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: GMPR2
is encoded by: hsa:51292

metaR r1948
modifier: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110056#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
fast: false
name: Y+LAT2 Utilized transport

metaR CYTK3n
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
kinetic law: MODEL1310110056#
reversible: true
reactant: MODEL1310110056#
product: MODEL1310110056#
name: cytidylate kinase (dCMP,CTP),nuclear

metaM adrncoa c
is: http://identifiers.org/pubchem.compound/47205480
name: adrenyl coenzyme A
constant: false
boundary condition: false
initial amount: NaN
is: C16170
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0

metaM dutp c
has only substance units: false
is: C00460
boundary condition: false
name: dUTP
is: CHEBI:17625
constant: false
is: HMDB01191
type: Species
initial amount: NaN
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: SBO:0000247
initial concentration: 1.0

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_736c725d_d36d_486f_8f3f_ba8e244b603f
initial amount: NaN
boundary condition: true
is: E7EQF2
has only substance units: false
name: CROT
is encoded by: hsa:54677
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR FAOXC225x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)x
type: Reaction

metaR r0002
kinetic law: MODEL1310110056#
name: Active transport
reversible: true
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
fast: false
reactant: MODEL1310110056#

metaM 3hexdtricoa x
has only substance units: false
type: Species
name: 3,7,10-hexadecatrienoylcoa
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: HMDB02288
is: SBO:0000247
initial concentration: 1.0

metaR ACETONEt2
is described by: ECO:0000269
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
product: MODEL1310110056#
reversible: true
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
name: acetone transport via proton symport
modifier: MODEL1310110056#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_4e14d2ce_968e_4def_9bd4_94d587ba7a29
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4967
constant: false
has part: B4E3E9
is: SBO:0000297
initial concentration: NaN
name: DLD:DLST:OGDH:PDHX
type: Species

metaM 1p3h5c m
is: HMDB01369
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
initial amount: NaN
boundary condition: false
is: CHEBI:6151
constant: false

metaM estradiol r
boundary condition: false
initial amount: NaN
is: HMDB00151
constant: false
type: Species
has only substance units: false
is: CHEBI:16469
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
initial concentration: 1.0
name: estradiol
is: SBO:0000247

metaM imp c
is: SBO:0000247
is: CHEBI:58053
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
constant: false
is: HMDB00175
type: Species
initial amount: NaN
name: IMP
is: C00130

metaR EHGLAT2m
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.6.1.1
modifier: MODEL1310110056#
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
reversible: false
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
fast: false
is: SBO:0000176

metaM ha deg1 l
name: hyaluronan degradation product 1
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:16336
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C22H33N2O16 CHARGE: -1

metaM focytC m
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: CHEBI:16928
name: Ferrocytochrome C
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR Htg
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: proton diffusion (Golgi)
kinetic law: MODEL1310110056#
is described by: ECO:0000000
product: MODEL1310110056#
reversible: true
fast: false
reactant: MODEL1310110056#
type: Reaction

metaR FAOXC61x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)x
type: Reaction

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_e6c5d725_42e4_45c2_95e5_9747466ba178
initial concentration: NaN
name: GGCT
initial amount: NaN
is: B8ZZR8
constant: false
has only substance units: false
is encoded by: hsa:79017
boundary condition: true
is: SBO:0000252
type: Species

metaR ASAH1
type: Reaction
name: N-acylsphingosine amidohydrolase
is: SBO:0000176
reactant: MODEL1310110056#
fast: false
product: MODEL1310110056#
is described by: ECO:0000000
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (427.1) or (427.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.5.1.23 Confidence Level: 4 AUTHORS: PMID:8955159 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.5.1.23
modifier: MODEL1310110056#
reversible: false

metaM thbpt4acam c
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:15374
boundary condition: false
constant: false
initial concentration: 1.0
name: 4a-hydroxytetrahydrobiopterin
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
has only substance units: false
is: HMDB02281

http://identifiers.org/biomodels.db/MODEL1310110056#_d7a9fdfd_04a2_4e27_ab2e_c3382d16c6be
name: _AA629629_1_m
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:AA629629
initial amount: NaN

metaR r2471
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12748860 NOTES:
type: Reaction
fast: false
reversible: false
product: MODEL1310110056#
name: Major Facilitator(MFS) TCDB:2.A.18.8.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_ba5e22ff_101f_462a_93be_687ce7172733
is encoded by: hsa:5151
has only substance units: false
constant: false
name: PDE8A
initial concentration: NaN
is: SBO:0000252
is: O60658
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_81d17c47_da4c_4194_bb1a_a2dd36d05596
constant: false
boundary condition: true
is: Q8NFW8
is: SBO:0000252
name: CMAS
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:55907

metaR r1949
type: Reaction
reactant: MODEL1310110056#
is described by: ECO:0000000
kinetic law: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110056#
is: SBO:0000185
name: Y+LAT2 Utilized transport
reversible: false
modifier: MODEL1310110056#

metaM HC00822 l
initial amount: NaN
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
type: Species
is: CHEBI:28681
initial concentration: 1.0
is: SBO:0000247
name: Chitobiose
boundary condition: false
constant: false
has only substance units: false

metaM 4mlacac c
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
is: HMDB02052
constant: false
is: CHEBI:17105
name: 4-maleylacetoacetate
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_9f97f31b_c682_4eae_ae07_02ccc97e83a0
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
name: HGD
is: SBO:0000252
has only substance units: false
is: Q93099
is encoded by: hsa:3081
boundary condition: true

metaR RE3627M
product: MODEL1310110056#
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
name: RE3627
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: true
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:

metaR FAOXC2051843x
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
name: Beta oxidation of long chain fatty acid
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
product: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000269
fast: false

metaM acac c
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: HMDB00060
is: SBO:0000247
type: Species
is: CHEBI:13705
initial concentration: 1.0
name: acetoacetate

metaR S4TASE1ly
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
name: N-acetylgalactosamine-4-sulfatase, lysosomal
product: MODEL1310110056#
is: SBO:0000176
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.12
reactant: MODEL1310110056#

metaM apoC Lys m
is: HMDB00182
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:32551
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Apocarboxylase (Lys residue)
type: Species
notes: FORMULA: C6H13N2OX CHARGE: 0

metaR TYRt
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
reversible: true
name: L-tyrosine transport
reactant: MODEL1310110056#
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_4155481a_a0e8_496c_af6b_7ae45d2fe67d
constant: false
initial amount: NaN
is encoded by: hsa:386757
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
name: SLC6A10P
type: Species

metaR NACHEXA11ly
kinetic law: MODEL1310110056#
name: beta-N-acetylhexosaminidase A, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110056#
is: SBO:0000176
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
type: Reaction
product: MODEL1310110056#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110056#_7386e128_81e5_4aea_86c7_ff6eb06b372d
boundary condition: true
initial concentration: NaN
name: GALNT14
type: Species
is: SBO:0000252
is: Q96FL9
initial amount: NaN
constant: false
is encoded by: hsa:79623
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_22c12989_7155_4bc8_8cfb_0d070285ea3f
boundary condition: true
initial concentration: NaN
is encoded by: hsa:124637
initial amount: NaN
name: CYB5D1
has only substance units: false
is: Q6P9G0
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_f69cde35_e33c_4003_8ac2_eb8b29cf7391
type: Species
name: UGP2
is encoded by: hsa:7360
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_7e4ea630_ec6b_4b6d_814f_65ff91d46ff3
is encoded by: hsa:411
is: A8K4A0
is: SBO:0000252
type: Species
constant: false
name: ARSB
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_7471b9e5_8aad_4569_b593_5d3b11601cb8
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:111
constant: false
is: O95622
name: ADCY5
type: Species
initial concentration: NaN
boundary condition: true

metaR FACOAL244 1
name: fatty-acid--CoA ligase
fast: false
reversible: true
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
product: MODEL1310110056#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaM 3thexddcoa m
notes: FORMULA: C37H58N7O18P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: HMDB02014
is: SBO:0000247
name: 3-hydroxy trans7,10-hexadecadienoylcoa
boundary condition: false
has only substance units: false

metaM 3mb2coa m
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB01493
constant: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
type: Species
initial concentration: 1.0
is: CHEBI:57344
name: 3-methylbut-2-enoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110056#_5f161266_83c7_4592_97d6_5cc393543563
is: SBO:0000252
initial concentration: NaN
name: HAGHL
type: Species
initial amount: NaN
is encoded by: hsa:84264
boundary condition: true
constant: false
has only substance units: false

metaR RTOTALt
kinetic law: MODEL1310110056#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
name: RTOTAL transport
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110056#

metaM thym e
constant: false
is: CHEBI:17821
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00262
name: thymine
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178

metaR C3STDH1r
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.1.1.170
modifier: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ
kinetic law: MODEL1310110056#
name: C-3 sterol dehydrogenase (4-methylzymosterol)
product: MODEL1310110056#
is: SBO:0000176
reversible: false
type: Reaction
is described by: ECO:0000134

metaR S6T11g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110056#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
modifier: MODEL1310110056#
product: MODEL1310110056#
kinetic law: MODEL1310110056#

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaM ala D c
is: CHEBI:15570
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
initial amount: NaN
is: HMDB01310
type: Species
is: SBO:0000247
has only substance units: false
name: D-alanine

http://identifiers.org/biomodels.db/MODEL1310110056#_fa5cf201_2d8f_49c1_a287_2937841625cc
constant: false
is: SBO:0000252
is: Q6ZMR3
initial concentration: NaN
name: LDHAL6A
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:160287

metaR RDH1
is version of: http://identifiers.org/ec-code/1.1.1.315
fast: false
kinetic law: MODEL1310110056#
reversible: true
modifier: MODEL1310110056#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
name: retinol dehydrogenase (all-trans)
product: MODEL1310110056#
is described by: ECO:0000269
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_f336374a_a67d_42e9_bb54_3946d56e03cf
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:55753
is: Q9ULD0
initial concentration: NaN
type: Species
name: OGDHL

metaR FAOXC161C141x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C16:1-->C14:1)x
type: Reaction

metaM core4 g
has only substance units: false
is: SBO:0000247
is: CHEBI:16478
boundary condition: false
constant: false
type: Species
name: Core 4
notes: FORMULA: C24H40N3O15X CHARGE: 0
initial concentration: 1.0
initial amount: NaN

metaM acac e
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00060
type: Species
is: CHEBI:13705
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial concentration: 1.0
constant: false
name: acetoacetate

metaR RDH2
modifier: MODEL1310110056#
name: retinol dehydrogenase (9-cis,NADH)
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.315
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
fast: false
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_a86e7362_45b2_4e3e_a359_37402457b79f
is: P19174
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5335
name: PLCG1
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
boundary condition: true

metaM dpcoa c
type: Species
is: CHEBI:57328
is: C00882
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: Dephospho-CoA
initial concentration: 1.0
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
constant: false
is: HMDB01373

metaM mal L x
initial concentration: 1.0
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
has only substance units: false
is: HMDB00156
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
name: (S)-malate(2-)
type: Species

metaR FACOAL260
reactant: MODEL1310110056#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110056#
is: SBO:0000176
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:cytoplasmic version -NJ
name: fatty-acid--CoA ligase (n-C26:0)

http://identifiers.org/biomodels.db/MODEL1310110056#_dd830db2_b813_43ed_a690_c7816ea1275b
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:4713
initial amount: NaN
boundary condition: true
name: NDUFB7
is: P17568
type: Species
has only substance units: false

metaR r0575
modifier: MODEL1310110056#
fast: false
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
kinetic law: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.1.48
product: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
reversible: true

metaR GLCNACASE1ly
type: Reaction
reactant: MODEL1310110056#
name: alpha-N-acetylglucosaminidase, lysosomal
is: SBO:0000176
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.50
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110056#_758a1be6_f944_4aad_82ed_a3f061bcb542
name: SLC16A7
is encoded by: hsa:9194
boundary condition: true
is: Q8NEM3
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN

metaR THCHOLSTOICtm
type: Reaction
product: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110056#
reversible: true
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ

http://identifiers.org/biomodels.db/MODEL1310110056#_7f54ca36_7222_4105_a92c_10d9f1eef757
name: _D87002_1_e
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:D87002
is: SBO:0000252
type: Species
initial amount: NaN

metaR TETHEX3COAtx
type: Reaction
fast: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
name: fatty acid intracellular transport
product: MODEL1310110056#
reactant: MODEL1310110056#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_9c9270c2_16b0_48f9_8c4b_642bb00d769f
name: SUCLG2
constant: false
initial concentration: NaN
initial amount: NaN
is: Q96I99
boundary condition: true
type: Species
is encoded by: hsa:8801
has only substance units: false
is: SBO:0000252

metaM dpcoa l
name: 3'-dephospho-CoA(2-)
is: HMDB01373
boundary condition: false
type: Species
constant: false
is: CHEBI:57328
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM sbcoa x
type: Species
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
boundary condition: false
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
is: SBO:0000247
name: suberylcoa
initial concentration: 1.0
initial amount: NaN
constant: false

metaR SUCCOAPET
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaR RE1530C
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
fast: false
product: MODEL1310110056#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
name: RE1530
reversible: true

metaR 4HGLSDm
is version of: http://identifiers.org/ec-code/1.5.1.12
product: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
modifier: MODEL1310110056#
reversible: true
reactant: MODEL1310110056#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
is described by: ECO:0000212
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial

metaR TYRTA
is described by: ECO:0000269
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110056#
name: tyrosine transaminase
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110056#
type: Reaction
reversible: true

metaM hco3 m
is: SBO:0000247
is: HMDB00595
is: C00288
type: Species
initial amount: NaN
has only substance units: false
name: Bicarbonate
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:17544

metaM dpcoa m
name: 3'-dephospho-CoA(2-)
is: CHEBI:57328
initial amount: NaN
is: SBO:0000247
is: HMDB01373
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
constant: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882

metaM ump e
constant: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: UMP(2-)
is: CHEBI:57865
is: HMDB00288
boundary condition: false
is: SBO:0000247
type: Species

metaR NADPHtru
fast: false
name: NADPH transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000185
reversible: false
type: Reaction
reactant: MODEL1310110056#
is described by: ECO:0000000

metaM omhpal c
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB06294
boundary condition: false
name: w-hydroxypalmiticacid
initial concentration: 1.0
notes: FORMULA: C16H30O3 CHARGE: -1

metaM ala D e
boundary condition: false
is: SBO:0000247
is: CHEBI:15570
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
initial concentration: 1.0
constant: false
name: D-alanine
initial amount: NaN
type: Species
is: HMDB01310
has only substance units: false

metaM txa2 c
initial concentration: 1.0
is: CHEBI:57445
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: HMDB01452
name: thromboxane A2(1-)
type: Species
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198

http://identifiers.org/biomodels.db/MODEL1310110056#_678ce858_69a5_4f53_89fb_7c3e85bdbe0c
is encoded by: hsa:6575
constant: false
boundary condition: true
has only substance units: false
type: Species
is: B2RBR4
initial concentration: NaN
name: SLC20A2
is: SBO:0000252
initial amount: NaN

metaM 2hexdtetcoa x
is: HMDB02288
has only substance units: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
name: 2,7,10,13-hexadecatetraenoylcoa
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_35013126_dab0_4f41_a01a_422a798fb228
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: IDI1
type: Species
initial amount: NaN
is: Q13907
is encoded by: hsa:3422

http://identifiers.org/biomodels.db/MODEL1310110056#_9dac5008_42b9_4ff8_b374_6ef0886948c0
initial concentration: NaN
name: GCNT3
has only substance units: false
boundary condition: true
is encoded by: hsa:9245
type: Species
is: O95395
is: SBO:0000252
constant: false
initial amount: NaN

metaM ksi deg39 l
type: Species
boundary condition: false
notes: FORMULA: C48H81N3O36 CHARGE: 0
is: CHEBI:12936
constant: false
initial amount: NaN
is: HMDB00143
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 39

metaR r1088
reactant: MODEL1310110056#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Active transport
product: MODEL1310110056#

metaR ARACHCRNt
is described by: ECO:0000000
reactant: MODEL1310110056#
reversible: false
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110056#
is: SBO:0000185
fast: false
product: MODEL1310110056#
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction

metaM leugly c
type: Species
name: Leucylglycine
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/97364
initial concentration: 1.0
notes: FORMULA: C8H16N2O3 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110056#_35716e7f_8476_4d41_8146_3b63e96fd6c5
name: TMEM91
constant: false
is: SBO:0000252
is: C9JZ62
is encoded by: hsa:641649
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN

metaM 3hodcoa m
type: Species
is: http://identifiers.org/pubchem.compound/5280355
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
name: (S)-3-Hydroxyoctadecanoyl-CoA

metaR CYSGLTH
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110056#
reversible: true
fast: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
name: Glutathione:cystine oxidoreductase
reactant: MODEL1310110056#

metaR NACHEXA18ly
reactant: MODEL1310110056#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction

metaR ADK3m
modifier: MODEL1310110056#
name: adentylate kinase (GTP)
is described by: ECO:0000269
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.4.10
product: MODEL1310110056#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
type: Reaction
is: SBO:0000176

metaM mal L m
is: HMDB00156
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:15589
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
type: Species
initial concentration: 1.0
name: (S)-malate(2-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_54e5a71b_ae21_4c69_a445_3a385fb5e4f3
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:257068
has only substance units: false
is: Q0VAA5
type: Species
name: PLCXD2

http://identifiers.org/biomodels.db/MODEL1310110056#_f1f2f735_493e_4b64_b1df_31b2cbcc4eb5
initial amount: NaN
is: SBO:0000252
is: Q16647
name: PTGIS
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5740
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_82959f70_cb1f_494f_a1ad_550a700a80d0
is: P17516
is: SBO:0000252
is encoded by: hsa:1109
name: AKR1C4
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true

metaR r0156
is described by: ECO:0000000
fast: false
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
is: SBO:0000176
reversible: false
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#

metaR NACHEX1ly
reactant: MODEL1310110056#
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
is: SBO:0000176
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000000
fast: false
type: Reaction

metaM thr L e
constant: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: HMDB00167
has only substance units: false
initial amount: NaN
name: L-threonine
is: CHEBI:16857
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaM ump c
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
constant: false
is: C00105
initial amount: NaN
name: UMP
boundary condition: false
is: CHEBI:57865
is: HMDB00288
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_dc9ed154_55f5_4f51_a3df_b69c20b395bf
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4712
initial concentration: NaN
is: Q5VYT2
type: Species
name: NDUFB6
is: SBO:0000252

metaR r1527
reactant: MODEL1310110056#
is described by: ECO:0000000
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
is: SBO:0000185
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/4.2.1.1
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
modifier: MODEL1310110056#
product: MODEL1310110056#
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_e12bf763_1921_4524_9af9_0dabdd68b74a
constant: false
is encoded by: hsa:3938
boundary condition: true
type: Species
initial amount: NaN
is: P09848
name: LCT
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_5febf07e_84c7_437a_a495_16c3c5238ba1
constant: false
is encoded by: hsa:9058
type: Species
initial amount: NaN
name: SLC13A2
is: E7ETH5
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM 3thexddcoa c
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: 3-hydroxy trans7,10-hexadecadienoylcoa
initial amount: NaN
notes: FORMULA: C37H58N7O18P3S CHARGE: -4
boundary condition: false
is: HMDB02014
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_a88b3f0e_8274_44e8_8e16_d1f7f8b79af2
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is: P40926
type: Species
is encoded by: hsa:4191
initial amount: NaN
name: MDH2

metaR GAPD
is version of: http://identifiers.org/ec-code/1.2.1.12
is described by: ECO:0000134
modifier: MODEL1310110056#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
reactant: MODEL1310110056#
fast: false
type: Reaction
product: MODEL1310110056#
name: glyceraldehyde-3-phosphate dehydrogenase

metaM leugly e
constant: false
name: Leucylglycine
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/97364
boundary condition: false
type: Species
notes: FORMULA: C8H16N2O3 CHARGE: 0
initial concentration: 1.0

metaR r0157
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
is version of: http://identifiers.org/ec-code/6.3.4.2
is: SBO:0000176
fast: false
reversible: false
type: Reaction
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
product: MODEL1310110056#
modifier: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#

metaR FBA
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/4.1.2.13
name: fructose-bisphosphate aldolase
reactant: MODEL1310110056#
is: SBO:0000176
product: MODEL1310110056#
reversible: true
kinetic law: MODEL1310110056#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110056#_cab3ed0f_e8e3_4466_8906_051bd7e4aa8a
type: Species
name: SLC2A1
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is: P11166
is encoded by: hsa:6513

http://identifiers.org/biomodels.db/MODEL1310110056#_87fb1789_67fe_4150_8642_bc7adff8519b
initial amount: NaN
is: C9JC79
constant: false
is: SBO:0000252
is encoded by: hsa:6342
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
name: SCP2

metaR MAN1PT2
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.13
reactant: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
type: Reaction
modifier: MODEL1310110056#
fast: false
name: mannose-1-phosphate guanylyltransferase (GDP)
kinetic law: MODEL1310110056#
product: MODEL1310110056#

metaR r0579
is version of: http://identifiers.org/ec-code/1.13.11.19
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
type: Reaction
reactant: MODEL1310110056#
reversible: true
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_c91b2fad_63b6_4eb6_9114_5524a65ec8fe
is: SBO:0000252
type: Species
name: ECHDC2
initial amount: NaN
boundary condition: true
is encoded by: hsa:55268
initial concentration: NaN
has only substance units: false
is: Q86YB7
constant: false

metaR IDOAASE3ly
product: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.76
is described by: ECO:0000000
fast: false
is: SBO:0000176
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: false
reactant: MODEL1310110056#
name: alpha-L-iduronidase, lysosomal

metaR EX txa2 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thromboxane A2 exchange
type: Reaction

metaR NACHEX21ly
is: SBO:0000176
modifier: MODEL1310110056#
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_f4d47dca_62bb_492b_bf55_28711f058dcf
constant: false
boundary condition: true
is: Q9NZK7
type: Species
name: PLA2G2E
initial concentration: NaN
is encoded by: hsa:30814
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM succoa c
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB01022
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
name: Succinyl-CoA

metaR LEUPHELAT2tc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_30efb296_ce45_4353_99e0_7d97f2537a6b
initial amount: NaN
boundary condition: true
name: PIGH
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is: Q14442
is encoded by: hsa:5283

metaR GLYPHEHYc
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
type: Reaction
reversible: true
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
product: MODEL1310110056#
fast: false
name: hydrolysis of glycylphenylalanine

http://identifiers.org/biomodels.db/MODEL1310110056#_9e3b0756_df32_4079_992e_d6323951f521
constant: false
name: SLC8A3
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:6547
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_6fe0cada_4d90_4b41_ae21_259713ff160b
boundary condition: true
is: B7Z3W8
name: SLC6A9
is: SBO:0000252
type: Species
is encoded by: hsa:6536
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false

metaM HC00822 e
is: CHEBI:28681
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
is: SBO:0000247
has only substance units: false
name: Chitobiose

http://identifiers.org/biomodels.db/MODEL1310110056#_3ffe4eb3_84b2_42e7_9675_0b3dc9e7b4e3
is encoded by: hsa:6487
is: Q96L53
name: ST3GAL3
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR Htr
type: Reaction
product: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reversible: true
fast: false
reactant: MODEL1310110056#
name: H transporter, endoplasmic reticulum
kinetic law: MODEL1310110056#

metaR EHGLATm
product: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
reversible: false
is: SBO:0000176
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000212

metaR SADT
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
name: sulfate adenylyltransferase
product: MODEL1310110056#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.25
reactant: MODEL1310110056#

metaM HC02179 c
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: CHEBI:34306
name: 20-hydroxy-arachidonate
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaM 4hpro LT m
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
is: CHEBI:18095
type: Species
is: HMDB00725
name: trans-4-hydroxy-L-proline
constant: false
has only substance units: false

metaR RE2659R
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
name: RE2659
product: MODEL1310110056#
fast: false
reversible: true
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

metaR C18OHc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecanoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_72f16351_164c_4b4c_94a1_ae43311faf8b
initial amount: NaN
constant: false
has only substance units: false
is: P48764
name: SLC9A3
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:6550

metaM xtsn c
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
name: xanthosine
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB00299
is: CHEBI:18107
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_b8a4b042_582b_41d5_966f_e2dabc21456d
is: E9PCI1
is encoded by: hsa:53
constant: false
is: SBO:0000252
name: ACP2
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true

metaM thbpt4acam n
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
name: 4a-hydroxytetrahydrobiopterin
type: Species
is: HMDB02281
initial amount: NaN
is: CHEBI:15374

metaR FAOXC205C184x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:4)x
type: Reaction

metaM but c
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
boundary condition: false
initial amount: NaN
constant: false
name: butyrate
type: Species
initial concentration: 1.0
is: HMDB00039
is: SBO:0000247
is: CHEBI:17968
has only substance units: false

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaM ump g
type: Species
name: UMP(2-)
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00288
is: CHEBI:57865
has only substance units: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN

metaM 3m4hpga c
type: Species
has only substance units: false
is: C05583
initial concentration: 1.0
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
is: http://identifiers.org/pubchem.compound/7909
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
is: SBO:0000247
boundary condition: false
is: HMDB04061
constant: false
initial amount: NaN

metaR r0578
product: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110056#
reactant: MODEL1310110056#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
fast: false
is version of: http://identifiers.org/ec-code/4.1.2.27
type: Reaction
kinetic law: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:

metaR FAOXC16180m
kinetic law: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
is described by: ECO:0000269
name: Beta oxidation fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
modifier: MODEL1310110056#
product: MODEL1310110056#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1

metaR r1698
is: SBO:0000185
modifier: MODEL1310110056#
is described by: ECO:0000000
product: MODEL1310110056#
type: Reaction
reversible: false
name: Y+LAT2 Utilized transport
fast: false
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR SERDGLNexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: D-Serine/Glutamine reversible exchange
product: MODEL1310110056#
is described by: ECO:0000304
modifier: MODEL1310110056#
reactant: MODEL1310110056#
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110056#
fast: false

metaM 3hexdtricoa m
type: Species
is: HMDB02288
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: 3,7,10-hexadecatrienoylcoa

http://identifiers.org/biomodels.db/MODEL1310110056#_39433d24_ca34_4782_8136_41a53d0127da
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: O14521
is encoded by: hsa:6392
name: SDHD

http://identifiers.org/biomodels.db/MODEL1310110056#_45869cc9_15b4_4e43_8501_1cf5e31efb93
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
name: HAGHL
is encoded by: hsa:84264
is: Q6PII5

metaM HC01842 c
constant: false
is: CHEBI:31997
initial amount: NaN
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
boundary condition: false
name: Phosphodimethylethanolamine
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species

metaR RE3005M
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110056#
reversible: true
kinetic law: MODEL1310110056#
product: MODEL1310110056#
fast: false
type: Reaction
modifier: MODEL1310110056#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
name: RE3005

http://identifiers.org/biomodels.db/MODEL1310110056#_47ec60f8_eb10_479a_bfb0_ec0801268394
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
type: Species
name: _AI769281_1_e
initial concentration: NaN
is encoded by: hsa:AI769281
has only substance units: false

metaR LNLCCRNt
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
reactant: MODEL1310110056#
name: transport into the mitochondria (carnitine)
is described by: ECO:0000269
modifier: MODEL1310110056#
type: Reaction
is: SBO:0000185
product: MODEL1310110056#
kinetic law: MODEL1310110056#

metaR HIBDm
reactant: MODEL1310110056#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
is described by: ECO:0000269
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.1.1.31
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
kinetic law: MODEL1310110056#
fast: false
reversible: true
modifier: MODEL1310110056#

metaM retinol 9 cis c
is: CHEBI:17336
type: Species
has only substance units: false
is: HMDB06217
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
boundary condition: false
name: 9-cis-retinol
initial amount: NaN

metaM acac x
initial amount: NaN
is: HMDB00060
constant: false
name: acetoacetate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
has only substance units: false
is: CHEBI:13705
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM anth c
has only substance units: false
is: HMDB01123
boundary condition: false
initial concentration: 1.0
is: CHEBI:16567
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
is: SBO:0000247
name: anthranilate
type: Species
constant: false
initial amount: NaN

metaR r1696
name: Y+LAT2 Utilized transport
product: MODEL1310110056#
is described by: ECO:0000000
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
reversible: false
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_5c86d57f_9a58_48ad_aebc_7d972dcc114c
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:R14373
name: _R14373_1_x
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaM 2hexdtetcoa m
is: HMDB02288
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial concentration: 1.0
name: 2,7,10,13-hexadecatetraenoylcoa
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_27d618f9_f96d_43bc_9b91_7940403f1427
boundary condition: true
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q8NFF2
is encoded by: hsa:123041
initial concentration: NaN
name: SLC24A4

metaR r2361
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
product: MODEL1310110056#
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport

metaR r1670
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110056#
fast: false
type: Reaction
reactant: MODEL1310110056#
reversible: true
modifier: MODEL1310110056#

metaR ILETAm
is described by: ECO:0000269
fast: false
name: isoleucine transaminase, mitochondrial
reactant: MODEL1310110056#
product: MODEL1310110056#
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.6.1.42
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110056#_df969763_71dd_419f_8348_e1411ada4353
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P33908
is encoded by: hsa:4121
initial amount: NaN
name: MAN1A1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_4b70452d_de4a_4700_bc9f_d6b99e4f05b7
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:4722
name: NDUFS3
initial concentration: NaN
boundary condition: true
is: O75489
initial amount: NaN
has only substance units: false

metaR HEDCECRNe
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecenoyl carnitine into extra cellular space
type: Reaction

metaM ksi pre34 g
is: C00130
initial concentration: 1.0
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
is: HMDB00175
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 34
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:58053
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_e20a0a53_1c07_4a81_bc99_50d32808a6a0
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: DCTD
is: P32321
has only substance units: false
is encoded by: hsa:1635
boundary condition: true
is: SBO:0000252

metaM cs c deg2 l
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 2
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C37H55NO38S2 CHARGE: -4
has only substance units: false
is: SBO:0000247
is: HMDB00127
initial amount: NaN
is: CHEBI:15748
type: Species

metaR RE2973N
reactant: MODEL1310110056#
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
kinetic law: MODEL1310110056#
product: MODEL1310110056#
fast: false
modifier: MODEL1310110056#
is: SBO:0000176
name: RE2973
is version of: http://identifiers.org/ec-code/2.7.1.154

metaR r1671
kinetic law: MODEL1310110056#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110056#
name: Y+LAT2 Utilized transport
product: MODEL1310110056#
fast: false
reactant: MODEL1310110056#
is described by: ECO:0000000

metaR r2362
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
product: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport

metaM cit c
is: HMDB00094
is: SBO:0000247
is: C00158
initial concentration: 1.0
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
name: Citrate
is: CHEBI:16947
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
constant: false

metaM retinol 9 cis e
is: HMDB06217
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
boundary condition: false
name: 9-cis-retinol
is: CHEBI:17336

http://identifiers.org/biomodels.db/MODEL1310110056#_01d3f2fd_0317_48aa_bd9d_0f621aa92896
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: OXSM
is: SBO:0000252
is encoded by: hsa:54995
boundary condition: true
is: Q9NWU1
constant: false
type: Species

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaR r2034
modifier: MODEL1310110056#
reversible: false
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110056#
kinetic law: MODEL1310110056#

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

metaR HEXCOAACBP
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexanoyl-CoA (n-C6:0CoA) from mitochondria into cytosol
type: Reaction

metaM HC01361 e
has only substance units: false
constant: false
is: CHEBI:17001
type: Species
name: Dihydroneopterin
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H13N5O4 CHARGE: 0 INCHI: InChI=1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1 EHMN_ABBREVIATION: C04874
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_cc278580_53db_4f5c_b08a_cfec87108f1c
has only substance units: false
initial amount: NaN
name: ATIC
boundary condition: true
is encoded by: hsa:471
is: P31939
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false

metaM btcoa x
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4
name: Butanoyl-CoA
boundary condition: false
is: C00136
type: Species
initial amount: NaN
is: HMDB01088

http://identifiers.org/biomodels.db/MODEL1310110056#_0a0eeb55_8139_4861_8a18_3677d3eabdf5
is: Q86YT5
name: SLC13A5
is encoded by: hsa:284111
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM pglyc hs e
name: phosphatidylglycerol(1-)
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
is: CHEBI:60523
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM 34dhphe c
is: CHEBI:15765
name: L-dopa
has only substance units: false
is: HMDB00181
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1

metaM ksi pre18 g
is: SBO:0000247
type: Species
has only substance units: false
is: C00130
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 18
is: HMDB00175
is: CHEBI:58053
notes: FORMULA: C163H262N11O132S5X CHARGE: -6

metaM malthp e
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
is: SBO:0000247
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
name: maltoheptaose
is: C01936
initial concentration: 1.0
has only substance units: false
type: Species

metaR r2360
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110056#
reversible: true
is: SBO:0000185
product: MODEL1310110056#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_24819803_b1d9_417f_9456_e59c0bcc2be9
type: Species
name: HK1
constant: false
is: B3KXY9
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3098
boundary condition: true

metaR PYRt2m
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
name: pyruvate mitochondrial transport via proton symport
type: Reaction
fast: false
reactant: MODEL1310110056#
reversible: true
kinetic law: MODEL1310110056#
is described by: ECO:0000000
modifier: MODEL1310110056#
is: SBO:0000185
product: MODEL1310110056#

metaR r1695
is described by: ECO:0000000
product: MODEL1310110056#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110056#
name: Y+LAT2 Utilized transport
reversible: false
modifier: MODEL1310110056#
reactant: MODEL1310110056#

metaM cit e
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: CHEBI:16947
constant: false
name: citrate(3-)
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00094
initial concentration: 1.0
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_523b8cc7_4922_4c14_a03a_9fe9b190b878
is: B7Z6M3
name: DGKZ
is encoded by: hsa:8525
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
constant: false

metaM 4hpro LT c
is: CHEBI:18095
is: SBO:0000247
name: trans-4-hydroxy-L-proline
initial amount: NaN
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
initial concentration: 1.0
boundary condition: false
is: HMDB00725
has only substance units: false
type: Species

metaM 4hoxpacd c
is: CHEBI:15621
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: (4-hydroxyphenyl)acetaldehyde
constant: false
initial concentration: 1.0
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
type: Species
has only substance units: false
is: HMDB03767

metaM cs c deg5 l
is: CHEBI:15936
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C23H36O24S CHARGE: -2
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 5

metaM dec47dicoa m
name: 4,7-decadienoylcoa
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
constant: false
type: Species
has only substance units: false

metaR r2365
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110056#
name: Organic anion transporter 5 Utilized transport
fast: false
is: SBO:0000185
reactant: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR r2036
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
reactant: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110056#_72611929_098d_41d5_bad6_8875e629f050
name: ADCY4
boundary condition: true
type: Species
is: Q8NFM4
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:196883

metaM acmana r
initial concentration: 1.0
is: SBO:0000247
constant: false
name: N-acetyl-D-mannosamine
is: CHEBI:17122
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: HMDB01129

http://identifiers.org/biomodels.db/MODEL1310110056#_f19f9d32_62e4_43cc_bb7d_c98e09af3d16
initial amount: NaN
is: B4E0V8
type: Species
constant: false
is encoded by: hsa:3034
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: HAL

http://identifiers.org/biomodels.db/MODEL1310110056#_b1114579_e750_4834_94a9_e8d4609dd50e
has only substance units: false
is encoded by: hsa:AA177072
initial concentration: NaN
initial amount: NaN
name: _AA177072_1_x
type: Species
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_7712e466_b156_4796_99c3_a22182421af2
constant: false
initial concentration: NaN
is encoded by: hsa:2592
boundary condition: true
type: Species
is: SBO:0000252
name: GALT
is: B4E097
has only substance units: false
initial amount: NaN

metaR r0426
kinetic law: MODEL1310110056#
type: Reaction
reversible: true
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
reactant: MODEL1310110056#
product: MODEL1310110056#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.34
is: SBO:0000176
modifier: MODEL1310110056#
is described by: ECO:0000000

metaR SACCD4m
product: MODEL1310110056#
modifier: MODEL1310110056#
reversible: false
is version of: http://identifiers.org/ec-code/1.5.1.8
is described by: ECO:0000269
reactant: MODEL1310110056#
name: saccharopine dehydrogenase (NAD, L-glutamate forming), mitochondrial
kinetic law: MODEL1310110056#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.10 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
type: Reaction

metaR C141OHe
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:1-OH
type: Reaction

metaM 34dhphe e
is: HMDB00181
is: CHEBI:15765
initial concentration: 1.0
initial amount: NaN
name: L-dopa
type: Species
has only substance units: false
constant: false
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
is: SBO:0000247
boundary condition: false

metaM pglyc hs c
is: SBO:0000247
name: pglyc_hs[c]
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB02704
notes: FORMULA: CHARGE: 0
is: CHEBI:21338
boundary condition: false
initial amount: NaN

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_8bb23b1c_3e00_4dfa_baba_d0de73b2fbcb
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is: Q9NXB9
name: ELOVL2
initial amount: NaN
is encoded by: hsa:54898

metaR r2366
reactant: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110056#
name: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
is: SBO:0000185

metaR C60CPT1
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexanoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_82dea286_1205_455b_9696_7cb96caf6ed3
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
name: AOX1
is: Q06278
is encoded by: hsa:316
has only substance units: false
initial concentration: NaN

metaM mgacpail hs r
is: CHEBI:7896
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
is: HMDB00220
initial amount: NaN
constant: false
is: SBO:0000247
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
is: C00249
has only substance units: false
type: Species
initial concentration: 1.0

metaR r0735
reactant: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.2.1.3
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
product: MODEL1310110056#
fast: false
is: SBO:0000176
reversible: true
modifier: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:

metaR GALtly
name: galactose efflux from lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reversible: false
fast: false
is: SBO:0000185
product: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
is described by: ECO:0000000

metaR r0571
modifier: MODEL1310110056#
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.5.1.8
name: (S)-Methylmalonyl-CoA hydrolase Propanoate metabolism EC:3.1.2.17
kinetic law: MODEL1310110056#
reversible: true
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.17 Confidence Level: 0 AUTHORS: PMID:3071714,PMID:6885824 NOTES:
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000

metaR GLUtr
product: MODEL1310110056#
kinetic law: MODEL1310110056#
name: intracellular transport
reversible: true
fast: false
reactant: MODEL1310110056#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, needed to transport glu-L out of ER in conversion of leuktrC4-> leuktrD4 NJ
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110056#_b59cc566_bcfd_4040_af98_52271af25695
name: TXNRD1
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:7296
constant: false
boundary condition: true

metaM anth e
is: CHEBI:16567
name: anthranilate
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB01123

metaM 4hpro LT e
name: trans-4-hydroxy-L-proline
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00725
initial concentration: 1.0
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1

metaR TYRTAm
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110056#
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (6898.1) or (2806.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: PMID:1973834 NOTES:NCD
name: tyrosine transaminase, mitochondrial
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.6.1.5
product: MODEL1310110056#
reversible: true

metaM m5masnB2 g
constant: false
notes: FORMULA: C52H87N2O40X CHARGE: 0
is: HMDB02985
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:58433
type: Species
boundary condition: false

metaM txa2 e
is: HMDB01452
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
name: thromboxane A2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:57445

metaR r2363
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: true
type: Reaction
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_c4350d77_2eec_4a93_9286_fd0889978196
initial concentration: NaN
is: Q7GXZ8
type: Species
constant: false
name: COX2
has only substance units: false
boundary condition: true
is encoded by: hsa:4513
is: SBO:0000252
initial amount: NaN

metaR FAOXC225m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_079d6ac2_9ffb_4da0_9681_1f25feb5481e
is encoded by: hsa:5372
type: Species
name: PMM1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: A8K003
constant: false
has only substance units: false

metaR r0570
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
is: SBO:0000176
modifier: MODEL1310110056#
is described by: ECO:0000000
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/6.3.3.2
fast: false
reversible: true
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
type: Reaction
product: MODEL1310110056#
kinetic law: MODEL1310110056#

metaR C16OHc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecanoylcarnitinec
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_3ad2730c_433c_4f39_ac95_5d6d9d5c1230
type: Species
name: SLCO3A1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is: Q9UIG8
is encoded by: hsa:28232

http://identifiers.org/biomodels.db/MODEL1310110056#_b113e112_7450_4049_a9b5_938a1864be78
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4258
initial concentration: NaN
is: D6RBB5
name: MGST2
boundary condition: true
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_16828f54_24f3_421c_8ae2_629738f4c7f5
has only substance units: false
is encoded by: hsa:126129
type: Species
is: Q8TCG5
constant: false
boundary condition: true
name: CPT1C
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR r0424
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.17.1.4
modifier: MODEL1310110056#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110056#
reversible: true
kinetic law: MODEL1310110056#
product: MODEL1310110056#

metaM 4hexdtetcoa x
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
name: 4,7,10,13-hexadecatetraenoylcoa
is: HMDB02288
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR AMANK
reversible: false
is: SBO:0000176
name: N-acetyl-D-mannosamine kinase
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.59
fast: false
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000269
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES:JLR - Kegg R02705
is version of: http://identifiers.org/ec-code/5.1.3.14

metaM utp n
is: HMDB00285
initial concentration: 1.0
type: Species
boundary condition: false
name: UTP(4-)
is: CHEBI:46398
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075

metaR BGLUGCHe
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of betaglucans with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR r2364
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reactant: MODEL1310110056#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM ca2 c
constant: false
name: calcium(2+)
initial amount: NaN
is: HMDB00464
is: SBO:0000247
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:29108
initial concentration: 1.0

metaR MG2er
product: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
reactant: MODEL1310110056#
reversible: false
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
fast: false
kinetic law: MODEL1310110056#

metaR UAGALDP
product: MODEL1310110056#
reactant: MODEL1310110056#
name: UDP-N-acetylgalactosamine diphosphorylase
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_23b778a0_cf4c_4376_ab4e_19745208231b
name: ACADL
has only substance units: false
is encoded by: hsa:33
initial concentration: NaN
is: P28330
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252

metaR GULN3D
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110056#
name: L-gulonate 3-dehydrogenase
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_8c81be8b_4af5_4090_9d53_fbc33b5e5265
name: ACOT8
is: O14734
is encoded by: hsa:10005
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM gtp c
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:37565
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: HMDB01273
is: C00044
constant: false
name: GTP
has only substance units: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110056#_333d4f0b_a70f_4b94_b9f8_cd91c3c3f9d3
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
name: _100128062_1_m
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:100128062
constant: false

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaR DM atp c
reversible: false
name: DM_atp(c)
product: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000134
fast: false
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:

metaM but m
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
constant: false
is: CHEBI:17968
initial concentration: 1.0
type: Species
initial amount: NaN
name: butyrate
is: SBO:0000247
boundary condition: false
is: HMDB00039
has only substance units: false

metaR MM8Ber
notes: GENE_ASSOCIATION: (11253.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10409699,PMID:9592125 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110056#
reactant: MODEL1310110056#
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.113
reversible: false
fast: false
kinetic law: MODEL1310110056#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, endoplasmic reticulum
is: SBO:0000176
type: Reaction

metaR r0845
reactant: MODEL1310110056#
reversible: false
fast: false
kinetic law: MODEL1310110056#
is described by: ECO:0000000
name: Drug/Metabolite Transporter (DMT) TCDB:2.A.7.12.7
product: MODEL1310110056#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12759756,PMID:17466261,PMID:9759482 NOTES:UGLCNACtg but different compartment

metaM dopa e
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:59905
type: Species
name: dopaminium(1+)
is: HMDB00073
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
constant: false

metaR r0009
product: MODEL1310110056#
fast: false
reactant: MODEL1310110056#
type: Reaction
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
is described by: ECO:0000000
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.6.1.1
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
reversible: false
is: SBO:0000176

metaM emgacpail hs r
constant: false
type: Species
has only substance units: false
name: phosphoethanolaminyl-mannosyl-glucosylaminyl-acylphosphatidylinositol (H5)
boundary condition: false
notes: FORMULA: C39H74N2O22P2FULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16038
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR MALtm
is described by: ECO:0000269
fast: false
modifier: MODEL1310110056#
reversible: true
reactant: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
name: malate transport, mitochondrial
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_5443a255_0852_4acb_a9a7_c7633961215f
is: SBO:0000252
is: P30038
type: Species
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
name: ALDH4A1
is encoded by: hsa:8659
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_84f9ac01_e604_43fd_8a09_2668c4879caa
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:7991
initial amount: NaN
constant: false
name: TUSC3
is: SBO:0000252
boundary condition: true

metaM 4hexdtetcoa m
is: HMDB02288
name: 4,7,10,13-hexadecatetraenoylcoa
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR r2369
fast: false
product: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction

metaR DNDPt16m
name: dUDP transport via dADP antiport
type: Reaction
product: MODEL1310110056#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
modifier: MODEL1310110056#
reversible: false
kinetic law: MODEL1310110056#

metaM trdrd m
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:15967
initial amount: NaN
constant: false
name: Reduced thioredoxin
type: Species
initial concentration: 1.0
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342

http://identifiers.org/biomodels.db/MODEL1310110056#_74778ca9_0b8e_4142_9868_c575c016922c
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: COQ2
is: Q96H96
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:27235

metaR r0423
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
fast: false
reactant: MODEL1310110056#
is: SBO:0000176
modifier: MODEL1310110056#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110056#

metaM acmana e
initial concentration: 1.0
name: N-acetyl-D-mannosamine
initial amount: NaN
is: CHEBI:17122
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
is: SBO:0000247
constant: false
boundary condition: false
type: Species
is: HMDB01129
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_93c13d68_d235_4dde_8f66_7dd91b2e83f8
initial amount: NaN
is encoded by: hsa:84693
is: Q96PE7
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
type: Species
name: MCEE
initial concentration: NaN

metaM CE2839 e
has only substance units: false
is: C01936
initial amount: NaN
name: maltodecaose
is: http://identifiers.org/pubchem.compound/5041
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839

metaM man g
name: D-mannose
is: CHEBI:16024
is: HMDB00169
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false
boundary condition: false
type: Species
has only substance units: false

metaM ksi pre2 g
boundary condition: false
is: HMDB00175
is: C00130
initial amount: NaN
is: CHEBI:58053
constant: false
name: keratan sulfate I biosynthesis, precursor 2
notes: FORMULA: C87H142N6O62X CHARGE: -1
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_a71c03b1_a5b1_45ff_a6c8_bc390af63884
name: NAGA
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4668
boundary condition: true
is: P17050
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_4515e88d_761c_4dad_a062_3904380121c8
constant: false
is encoded by: hsa:50614
type: Species
is: Q9HCQ5
initial concentration: NaN
name: GALNT9
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_3c8e7c25_11cd_44f2_8e93_63849579fce1
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1743
type: Species
is: P36957
boundary condition: true
constant: false
name: DLST

metaM ca2 e
is: HMDB00464
has only substance units: false
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
name: calcium(2+)
is: CHEBI:29108
type: Species

metaR EX c6crn
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hexanoyl carnitine
type: Reaction

metaM thym c
name: Thymine
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
initial concentration: 1.0
is: C00178
constant: false
is: HMDB00262
is: CHEBI:17821
has only substance units: false
initial amount: NaN

metaR FAOXTC102C101m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:2-->C10:1)m
type: Reaction

metaR SGALSIDEtg
is described by: ECO:0000000
reversible: true
name: sgalside hs intracellular transport
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000185
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
fast: false
type: Reaction

metaR ADSL1
type: Reaction
is version of: http://identifiers.org/ec-code/4.3.2.2
product: MODEL1310110056#
name: adenylosuccinate lyase
modifier: MODEL1310110056#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#

metaR DDPGAm
is described by: ECO:0000000
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
fast: false
product: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
is: SBO:0000176
reversible: true

metaR r0422
is: SBO:0000176
modifier: MODEL1310110056#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
fast: false
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110056#
reversible: true
product: MODEL1310110056#

metaM CE4794 m
name: cis-6-dodecenoyl-CoA
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
has only substance units: false
is: CHEBI:57923
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false

metaR UDPGALtg
is described by: ECO:0000269
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
name: UDP-Gal Golgi transport via CMP antiport
is: SBO:0000185
product: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD

metaM succoa m
is: HMDB01022
type: Species
has only substance units: false
is: CHEBI:57292
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
name: Succinyl-CoA
is: SBO:0000247

metaM dutp m
boundary condition: false
type: Species
is: HMDB01191
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:17625
name: dUTP

metaM gtp e
initial concentration: 1.0
has only substance units: false
is: CHEBI:37565
boundary condition: false
constant: false
is: HMDB01273
name: GTP(4-)
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial amount: NaN
is: SBO:0000247
type: Species

metaR GTHPm
fast: false
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.11.1.12
is version of: http://identifiers.org/ec-code/1.11.1.15
is: SBO:0000176
reversible: true
modifier: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
is described by: ECO:0000269
name: glutathione peroxidase, mitochondria
reactant: MODEL1310110056#

metaM dopa c
initial concentration: 1.0
constant: false
is: CHEBI:59905
is: SBO:0000247
type: Species
name: dopaminium(1+)
is: HMDB00073
boundary condition: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
initial amount: NaN
has only substance units: false

metaR r2367
reactant: MODEL1310110056#
reversible: true
name: Organic anion transporter 5 Utilized transport
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000185

metaM taur e
is: CHEBI:3544
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C2H7NO3S CHARGE: 0
is: HMDB00251
name: Taurine
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: C00245

metaR ABTti
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
type: Reaction
product: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reversible: false
name: L-arabinitol transport via passive diffusion

metaR HISSNAT5tc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_cfd87866_0bec_47a7_98e3_5fcee4664ac2
name: AICDA
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q546Y9
type: Species
is encoded by: hsa:57379

metaM hs deg8 l
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:16126
constant: false
name: heparan sulfate, degradation product 8

metaM HC01401 m
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27668
type: Species
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
name: (S)-3-Hydroxydodecanoyl-CoA
is: SBO:0000247

metaM s2l2n2m2mn l
has only substance units: false
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)
notes: FORMULA: C76H123N5O57 CHARGE: -2
initial concentration: 1.0
is: SBO:0000247
is: HMDB00573
is: CHEBI:30825
constant: false
boundary condition: false
initial amount: NaN
type: Species

metaM 1pyr5c c
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15893
name: 1-Pyrroline-5-carboxylate
is: C03912
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: HMDB01301

metaM CE0693 m
is: HMDB11123
initial concentration: 1.0
is: CHEBI:28387
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
has only substance units: false
type: Species
name: 3-oxolaur-6-cis-enoyl-CoA
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_762997d7_8adc_418f_b3ff_a71da58c487a
has part: P23378
is encoded by: hsa:2653
has part: P23434
has only substance units: false
is encoded by: hsa:2731
name: DLD:GCSH:GLDC:AMT
has part: P48728
is encoded by: hsa:275
boundary condition: true
is: SBO:0000297
type: Species
constant: false
initial amount: NaN
initial concentration: NaN

metaR KCCt
product: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
name: K+-Cl- cotransport
fast: false
kinetic law: MODEL1310110056#
is described by: ECO:0000269
reversible: true
type: Reaction
modifier: MODEL1310110056#

metaM dec47dicoa x
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
has only substance units: false
boundary condition: false
name: 4,7-decadienoylcoa
type: Species
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
initial concentration: 1.0

metaM man e
is: CHEBI:16024
initial concentration: 1.0
is: HMDB00169
name: D-Mannose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: C00159
constant: false
has only substance units: false
type: Species

metaM txa2 r
has only substance units: false
name: thromboxane A2(1-)
is: HMDB01452
constant: false
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57445
initial amount: NaN
boundary condition: false

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaR r2368
type: Reaction
product: MODEL1310110056#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_fd02724e_5663_445a_90e7_f2060c6d6aa1
name: _22305_1_c
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
is encoded by: hsa:22305
is: SBO:0000252

metaR C141OHc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_73c01ffe_6411_4ec7_b779_d38b059ebc2f
is: P19440
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
name: GGT1
is: SBO:0000252
is encoded by: hsa:2678

metaR FAOXC205C185m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_f600ebc2_70f9_4a4b_a038_2f613811496e
boundary condition: true
initial amount: NaN
is encoded by: hsa:10327
initial concentration: NaN
name: AKR1A1
is: SBO:0000252
has only substance units: false
is: P14550
constant: false
type: Species

metaR C140CPT1
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of myristoylcarnitine
type: Reaction

metaM cs e deg2 l
is: HMDB00812
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
is: SBO:0000247
is: CHEBI:16953
type: Species
constant: false
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
boundary condition: false
initial amount: NaN
has only substance units: false

metaR Asn X Ser Thrtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110056#
name: Asn-X-Ser/Thr transport (from ER to lysosome)
reversible: true

metaM taur c
initial concentration: 1.0
is: CHEBI:3544
constant: false
is: C00245
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00251
notes: FORMULA: C2H7NO3S CHARGE: 0
name: Taurine
boundary condition: false
initial amount: NaN

metaR r2141
is described by: ECO:0000000
fast: false
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR PYRt2r
name: pyruvate reversible transport via proton symport
is: SBO:0000185
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
is described by: ECO:0000269
reactant: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110056#_9772ab0a_b910_4931_b198_8745f6c62830
has only substance units: false
is encoded by: hsa:5832
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: ALDH18A1
initial concentration: NaN
constant: false
type: Species
is: P54886

metaR SUBERCACT
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberyl carnitine into cytosol
type: Reaction

metaM hdca r
name: Hexadecanoate (n-C16:0)
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: CHEBI:7896
has only substance units: false
is: HMDB00220
boundary condition: false
constant: false
is: C00249
is: SBO:0000247

metaR H2Otg
type: Reaction
fast: false
product: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110056#
is described by: ECO:0000000
name: H2O transport, Golgi apparatus
reversible: true
is: SBO:0000185

metaM prostgh2 e
boundary condition: false
initial concentration: 1.0
name: prostaglandin H2(1-)
is: HMDB01381
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
type: Species
has only substance units: false
is: CHEBI:57405

metaM dhor S c
is: CHEBI:30864
constant: false
type: Species
is: HMDB03349
name: (S)-dihydroorotate
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
initial concentration: 1.0
has only substance units: false

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

metaR r1090
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
product: MODEL1310110056#
reversible: false
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaM man c
is: SBO:0000247
has only substance units: false
is: C00159
is: HMDB00169
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false
name: D-Mannose
initial amount: NaN
type: Species
is: CHEBI:16024
boundary condition: false
initial concentration: 1.0

metaR r2142
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000185
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_db163849_31f5_42e2_b99a_80711133c399
is encoded by: hsa:M68895
initial concentration: NaN
type: Species
constant: false
boundary condition: true
initial amount: NaN
name: _M68895_1_c
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_c6c915ec_d7e7_4c19_9a1f_997dbbc60d83
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:55350
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: VNN3

http://identifiers.org/biomodels.db/MODEL1310110056#_482cfc0b_ba75_461e_9c8a_66d1d91d7d42
is encoded by: hsa:3033
boundary condition: true
initial concentration: NaN
type: Species
name: HADH
is: Q16836
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_c453fe4b_c7ce_4d8e_b972_263341548cf2
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
name: _AL038231_1_c
is encoded by: hsa:AL038231

metaM 2dpmhobq m
constant: false
boundary condition: false
type: Species
notes: FORMULA: C58H88O4 CHARGE: 0 INCHI: InChI=1S/C58H88O4/c1-43(2)23-14-24-44(3)25-15-26-45(4)27-16-28-46(5)29-17-30-47(6)31-18-32-48(7)33-19-34-49(8)35-20-36-50(9)37-21-38-51(10)39-22-40-52(11)41-42-54-53(12)55(59)57(61)58(62-13)56(54)60/h23,25,27,29,31,33,35,37,39,41,61H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b44-25+,45-27+,46-29+,47-31+,48-33+,49-35+,50-37+,51-39+,52-41+
is: CHEBI:50771
initial amount: NaN
name: 2-decaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone
has only substance units: false
is: HMDB06484
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110056#_9ec21e8c_02f6_4c6f_83d2_2b6e9683acff
boundary condition: true
constant: false
is encoded by: hsa:4702
initial amount: NaN
has only substance units: false
is: B1AM93
is: SBO:0000252
initial concentration: NaN
type: Species
name: NDUFA8

metaR SGALSIDEtl
is described by: ECO:0000000
kinetic law: MODEL1310110056#
name: sgalside hs intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is: SBO:0000185
product: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
reversible: true
fast: false

metaR FAOXC163C164x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)x
type: Reaction

metaR PYRt2p
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12705896,PMID:12739169,PMID:9786900 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110056#
name: pyruvate peroxisomal transport via proton symport
is described by: ECO:0000269
reactant: MODEL1310110056#
product: MODEL1310110056#
fast: false
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_07252f3a_e50b_435a_be60_09eff3d668d7
type: Species
is encoded by: hsa:8050
is: SBO:0000252
constant: false
is: O00330
initial amount: NaN
name: PDHX
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR LCYSTAT
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:described in PMID: 3346220 and KEGG MM
type: Reaction
kinetic law: MODEL1310110056#
is described by: ECO:0000304
name: L-Cysteate:2-oxoglutarate aminotransferase
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110056#
fast: false
product: MODEL1310110056#

metaR MI134P4P
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
name: inositol-1,3,4-trisphosphate 4-phosphatase
kinetic law: MODEL1310110056#
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000

metaM acac m
initial amount: NaN
name: acetoacetate
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00060
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: CHEBI:13705

metaR GLYt7 311 r
modifier: MODEL1310110056#
name: glycine reversible transport via sodium and chloride symport (3:1:1)
is described by: ECO:0000006
reversible: true
type: Reaction
product: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
kinetic law: MODEL1310110056#
is: SBO:0000185

metaM prostgh2 c
name: prostaglandin H2(1-)
boundary condition: false
initial concentration: 1.0
is: HMDB01381
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
has only substance units: false
constant: false
type: Species
is: CHEBI:57405

metaM dmpp x
is: SBO:0000247
constant: false
name: prenyl diphosphate(3-)
boundary condition: false
is: CHEBI:57623
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB01120
type: Species
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235

http://identifiers.org/biomodels.db/MODEL1310110056#_0abba48c_5adf_468d_aa05_b1ad5e17f868
constant: false
name: _AL525798_1_c
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AL525798
has only substance units: false
is: SBO:0000252

metaR C180CRNt
modifier: MODEL1310110056#
product: MODEL1310110056#
name: C180 transport into the mitochondria
kinetic law: MODEL1310110056#
reversible: false
type: Reaction
reactant: MODEL1310110056#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
is: SBO:0000185

metaR FAOXC221C201x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

metaR FUMm
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
is version of: http://identifiers.org/ec-code/4.2.1.2
reversible: true
is: SBO:0000176
modifier: MODEL1310110056#
name: fumarase, mitochondrial
reactant: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
is described by: ECO:0000134
fast: false

metaR GCC2bim
is described by: ECO:0000269
modifier: MODEL1310110056#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.10
reactant: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
fast: false
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.4.4.2
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.8.1.4

metaR GLCMter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11882499 NOTES:NCD
fast: false
reactant: MODEL1310110056#
reversible: false
type: Reaction
product: MODEL1310110056#
is described by: ECO:0000000
kinetic law: MODEL1310110056#
name: glucose transport via membrane vesicle
is: SBO:0000185

metaR G14T11g
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110056#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110056#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110056#
fast: false
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_f5c70bb7_16ef_47c1_baa7_18fb8fcb8767
constant: false
has only substance units: false
initial amount: NaN
name: AACS
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q86V21
is encoded by: hsa:65985
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_6fa6af53_1638_46d1_bd99_a5caa108d4b0
type: Species
constant: false
initial amount: NaN
boundary condition: true
name: EGFL8
initial concentration: NaN
is encoded by: hsa:80864
is: SBO:0000252
has only substance units: false
is: Q99944

metaM fol m
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00121
name: Folate
notes: FORMULA: C19H18N7O6 CHARGE: -1 INCHI: InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00396 EHMN_ABBREVIATION: C00504
boundary condition: false
has only substance units: false
is: CHEBI:27470
type: Species

metaR FAOXC61m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

metaR MM6B2g
modifier: MODEL1310110056#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.113
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is: SBO:0000176
product: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_965d4687_9931_40d0_b4b2_32cd9b3dc654
has only substance units: false
initial amount: NaN
is: P11168
name: SLC2A2
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:6514

http://identifiers.org/biomodels.db/MODEL1310110056#_54344c04_0ac7_45bf_866f_52db40e7e956
type: Species
boundary condition: true
is: P07864
is encoded by: hsa:3948
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
name: LDHC
has only substance units: false

metaM alpam m
is: HMDB06239
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
name: S-aminomethyldihydrolipoamide
boundary condition: false
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_8dd2dbaf_91b8_4409_adc2_81bf61a38ce4
is encoded by: hsa:3945
constant: false
name: LDHB
type: Species
is: P07195
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_f8caf798_633c_47d3_9501_1bea21650968
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:AI620219
name: _AI620219_1_m
initial concentration: NaN
has only substance units: false
type: Species

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaM pail34p hs c
type: Species
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
is: CHEBI:57658

metaM pan4p e
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
is: C01134
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: HMDB01416
has only substance units: false
initial concentration: 1.0
is: CHEBI:47942
constant: false
name: Pantetheine 4'-phosphate

metaM 3ddecdicoa x
type: Species
initial concentration: 1.0
boundary condition: false
name: 3,6-dodecadienoylcoa
is: HMDB03952
constant: false
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
is: C05280

metaM 34hpp c
is: SBO:0000247
is: CHEBI:36242
constant: false
type: Species
name: 3-(4-hydroxyphenyl)pyruvate
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
is: HMDB00707
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false

metaM pi c
has only substance units: false
is: SBO:0000247
is: C00009
initial concentration: 1.0
boundary condition: false
name: hydrogenphosphate
constant: false
is: HMDB00973
type: Species
notes: FORMULA: HO4P CHARGE: -2
is: CHEBI:43474
initial amount: NaN

metaR FAOXC180
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
reactant: MODEL1310110056#
name: Beta oxidation of long chain fatty acid
type: Reaction
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false

metaR TRIOK
is described by: ECO:0000000
kinetic law: MODEL1310110056#
product: MODEL1310110056#
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.28 Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000176
name: triokinase
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_a140e182_0067_4280_a5de_1103d90b61f8
has part: Q07326
name: PIGF:PIGO
initial amount: NaN
is encoded by: hsa:84720
initial concentration: NaN
constant: false
has part: Q8TEQ8
boundary condition: true
type: Species
is: SBO:0000297
is encoded by: hsa:5281
has only substance units: false

metaR r2140
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
modifier: MODEL1310110056#
product: MODEL1310110056#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110056#
is described by: ECO:0000000
kinetic law: MODEL1310110056#
reversible: true
fast: false

metaM glyald m
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial amount: NaN
type: Species
name: D-glyceraldehyde
has only substance units: false
is: HMDB01051
constant: false
is: CHEBI:17378

metaM pheacgln e
is: SBO:0000247
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
is: HMDB06344
is: CHEBI:58310
initial amount: NaN
constant: false

metaM 5adtststerone r
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
name: 17beta-hydroxy-5alpha-androstan-3-one
is: CHEBI:16330
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
constant: false
is: HMDB02961
is: SBO:0000247

metaR ACACtx
type: Reaction
is described by: ECO:0000000
name: acetoacetate intracellular transport unknown mechanism
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110056#
reversible: true
fast: false
product: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000185

metaM ac e
initial concentration: 1.0
is: SBO:0000247
is: HMDB00042
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:30089
boundary condition: false
name: acetate
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
constant: false

metaM ksii core2 pre2 g
type: Species
is: CHEBI:58053
has only substance units: false
is: HMDB00175
initial concentration: 1.0
constant: false
notes: FORMULA: C39H63N3O28X CHARGE: -1
boundary condition: false
initial amount: NaN
is: C00130
name: keratan sulfate II biosynthesis, precursor 2
is: SBO:0000247

metaR RE3628M
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110056#
is: SBO:0000176
name: RE3628
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/5.3.3.8

metaM hestratriol r
is: SBO:0000247
name: 4,17 dihydroxy estradiol
initial concentration: 1.0
type: Species
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
has only substance units: false
initial amount: NaN
is: HMDB05896
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_14bf693f_e913_4566_88c3_1150a333d366
name: _F23536_1_m
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:F23536
type: Species
initial concentration: NaN
has only substance units: false

metaR ORNDC
fast: false
reversible: false
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/4.1.1.17
notes: GENE_ASSOCIATION: (4953.1) SUBSYSTEM: Urea cycle EC Number: 4.1.1.17 Confidence Level: 4 AUTHORS: PMID:2317811 NOTES:JLR- added proton to balance
name: Ornithine Decarboxylase
is: SBO:0000176
reactant: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000269

metaM cholp c
name: choline phosphate(1-)
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:295975
type: Species
boundary condition: false

metaM man l
is: HMDB00169
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:16024
name: D-mannose
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_92657570_2f8e_4b69_8238_ff576bc3adb2
initial amount: NaN
name: NT5C1B
is: SBO:0000252
type: Species
has only substance units: false
constant: false
is: Q96P26
boundary condition: true
is encoded by: hsa:93034
initial concentration: NaN

metaM thcholstoic m
has only substance units: false
is: HMDB03873
is: CHEBI:18402
initial concentration: 1.0
is: SBO:0000247
constant: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
initial amount: NaN
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
type: Species
boundary condition: false

metaM csn e
initial amount: NaN
constant: false
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00630
name: cytosine
type: Species
has only substance units: false
is: CHEBI:16040

metaM succoa x
is: HMDB01022
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
name: Succinyl-CoA
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
boundary condition: false
has only substance units: false

metaM 34hpp e
type: Species
name: 3-(4-hydroxyphenyl)pyruvate
is: HMDB00707
initial amount: NaN
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:36242

metaR CYTK2n
modifier: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110056#
reversible: true
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
name: cytidylate kinase (dCMP),nuclear

http://identifiers.org/biomodels.db/MODEL1310110056#_a3b57784_cd24_4358_80f7_85cd91a4c9d1
boundary condition: true
name: HKDC1
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:80201
is: SBO:0000252
has only substance units: false
is: B3KT70

metaR DM anth
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaM Ser Gly Ala X Gly l
notes: FORMULA: XH CHARGE: 0
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
constant: false
name: protein-linked serine residue (glycosaminoglycan attachment site)
initial amount: NaN
is: HMDB02183
boundary condition: false
is: CHEBI:36005

metaR RE1531M
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
type: Reaction
name: RE1531
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
reactant: MODEL1310110056#

metaM pheacgln c
initial amount: NaN
is: HMDB06344
initial concentration: 1.0
is: CHEBI:58310
constant: false
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species

metaR DURAD2
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110056#
reactant: MODEL1310110056#
name: dihydrothymin dehydrogenase (NADP)
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.2

metaR UAGDP
reversible: false
fast: false
name: UDP-N-acetylglucosamine diphosphorylase
is: SBO:0000176
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.7.23
type: Reaction
is described by: ECO:0000269
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
modifier: MODEL1310110056#

metaM mi134p c
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
is: SBO:0000247
is: CHEBI:58414
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
initial amount: NaN
constant: false
is: HMDB01143
has only substance units: false

metaR NADH2 u10m
type: Reaction
is: SBO:0000185
name: NADH dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.6.5.3
reversible: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.6.99.3
is described by: ECO:0000134
reactant: MODEL1310110056#
product: MODEL1310110056#
fast: false

metaM HC01522 c
constant: false
is: CHEBI:28508
name: Gentisate aldehyde
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585

metaR TYMSFt
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
kinetic law: MODEL1310110056#
is: SBO:0000185
fast: false
reactant: MODEL1310110056#
product: MODEL1310110056#
name: Tyramine O-sulfate transport (diffusion)
reversible: false
type: Reaction

metaM ksi pre17 g
is: SBO:0000247
type: Species
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
initial amount: NaN
is: CHEBI:28067
constant: false
initial concentration: 1.0
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 17
has only substance units: false

metaR SERGLNexR
reactant: MODEL1310110056#
type: Reaction
reversible: true
is described by: ECO:0000304
modifier: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-Serine/Glutamine reversible exchange
kinetic law: MODEL1310110056#

metaR S3TASE2ly
reactant: MODEL1310110056#
product: MODEL1310110056#
name: N-acetylglucosamine-3-sulfatase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110056#
reversible: true
type: Reaction
fast: false
is: SBO:0000176

metaM amp m
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: HMDB00045
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:456215
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
name: AMP(2-)

metaM HC01397 m
type: Species
name: (S)-3-Hydroxyhexadecanoyl-CoA
boundary condition: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
is: CHEBI:27402
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR DNDPt9m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
type: Reaction
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
name: dADP transport via dTDP antiport
is: SBO:0000185
product: MODEL1310110056#
reactant: MODEL1310110056#

metaM ac c
boundary condition: false
is: HMDB00042
initial amount: NaN
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial concentration: 1.0
is: CHEBI:30089
constant: false
is: SBO:0000247
has only substance units: false
name: acetate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_dc9b3c88_1058_4b16_8a4f_7112e5dbbe95
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:5092
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
name: PCBD1

metaR r0013
is described by: ECO:0000000
type: Reaction
name: beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.52 Confidence Level: 0 AUTHORS: PMID:10481922,PMID:2423070,PMID:6219664,PMID:758959 NOTES:
fast: false
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: false
product: MODEL1310110056#
reactant: MODEL1310110056#

metaM akg m
is: SBO:0000247
is: CHEBI:16810
name: 2-Oxoglutarate
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: C00026
is: HMDB00208
constant: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110056#_626e2db2_cb48_4d93_8aab_abf0f119c2bc
is: B7Z792
type: Species
initial amount: NaN
name: NDUFS2
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:4720

metaR FUCASE2ly
modifier: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.51
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000000
product: MODEL1310110056#
name: alpha-fucosidase, lysosomal
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110056#_ed120969_a02f_4435_a787_76316c1737d6
is: P04746
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
name: AMY2A
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:279

metaR LAPCOAe
name: LAPCOAe
fast: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA catabolism EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
is: SBO:0000176
reversible: false
is described by: ECO:0000134

metaM csn c
name: cytosine
initial concentration: 1.0
has only substance units: false
is: CHEBI:16040
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
constant: false
is: HMDB00630
is: SBO:0000247

metaR IPDDIx
is: SBO:0000176
reactant: MODEL1310110056#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.3.2
kinetic law: MODEL1310110056#
reversible: true
name: isopentenyl-diphosphate D-isomerase
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
product: MODEL1310110056#
fast: false
type: Reaction

metaR PCHOLP hs
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
fast: false
name: choline phosphatase
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.4.4
type: Reaction
is described by: ECO:0000269

metaM btcoa m
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB01088
is: C00136
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
is: CHEBI:57371
initial concentration: 1.0
type: Species
name: Butanoyl-CoA
boundary condition: false

metaM mlthf m
is: C00143
constant: false
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01533
name: 5,10-Methylenetetrahydrofolate
is: CHEBI:15636
initial amount: NaN
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
boundary condition: false
initial concentration: 1.0

metaM m2mn l
initial amount: NaN
has only substance units: false
is: HMDB06537
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: SBO:0000247
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1

metaR RE2426C
name: RE2426
is: SBO:0000176
fast: false
kinetic law: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
is described by: ECO:0000000
reactant: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:

metaR CRNt
type: Reaction
fast: false
kinetic law: MODEL1310110056#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
is: SBO:0000185
product: MODEL1310110056#
modifier: MODEL1310110056#
reactant: MODEL1310110056#
reversible: true
name: L-carnitine reversible transport

metaR PPCDC
kinetic law: MODEL1310110056#
name: phosphopantothenoylcysteine decarboxylase
reversible: false
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
reactant: MODEL1310110056#
product: MODEL1310110056#
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.36
modifier: MODEL1310110056#
type: Reaction

metaM pi g
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
name: hydrogenphosphate
initial amount: NaN
is: CHEBI:43474
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
is: HMDB00973
has only substance units: false

metaR GMPtg
type: Reaction
kinetic law: MODEL1310110056#
reversible: true
reactant: MODEL1310110056#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
product: MODEL1310110056#
name: GMP transport (Golgi)
is: SBO:0000185
fast: false

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaM amp e
is: C00020
is: HMDB00045
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: SBO:0000247
type: Species
has only substance units: false
name: AMP
initial concentration: 1.0
is: CHEBI:456215

http://identifiers.org/biomodels.db/MODEL1310110056#_535e1962_c306_49e8_8998_7f247b5ca173
is: SBO:0000252
is: Q02127
type: Species
name: DHODH
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1723
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_e90018d8_0e3b_4749_a267_b715609034be
initial amount: NaN
type: Species
name: _AI631997_1_m
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:AI631997
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_ea24649e_01f4_4a73_aaf4_6544c5b2fb15
boundary condition: true
initial concentration: NaN
type: Species
is: Q01581
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3157
name: HMGCS1
constant: false
initial amount: NaN

metaM acmana c
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:17122
is: HMDB01129
initial concentration: 1.0
name: N-acetyl-D-mannosamine
initial amount: NaN
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645

metaR LEUKTRD4tr
fast: false
type: Reaction
name: leukotriene intracellular transport
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110056#

metaR H2Otm
type: Reaction
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
is described by: ECO:0000269
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000185
fast: false
name: H2O transport, mitochondrial
modifier: MODEL1310110056#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110056#_25041a49_4a42_4244_bb88_6e267a0608b0
name: DGKE
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8526
initial concentration: NaN
initial amount: NaN
is: A1L4Q0
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_2fb8a85f_72ae_437b_a7cc_f751e97fc198
name: SGPP2
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:130367
is: Q8IWX5
has only substance units: false

metaM cholp g
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: choline phosphate(1-)
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
constant: false
is: CHEBI:295975
boundary condition: false
initial amount: NaN
is: C00588
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_c22c8037_3c3a_4b7b_9baf_234c9ce35499
has only substance units: false
name: COX7A2
initial amount: NaN
boundary condition: true
is: H0UI06
type: Species
is encoded by: hsa:1347
constant: false
initial concentration: NaN
is: SBO:0000252

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaM hpdcacoa c
is: HMDB06497
has only substance units: false
constant: false
name: heptadecanoyl coa
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_04d2c3a2_2da5_461c_a265_fd46f1dcebc7
has only substance units: false
is: Q9NUD9
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:55650
is: SBO:0000252
name: PIGV
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_bcccdeb7_905c_4683_9ab4_bfd48372e97f
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:81539
initial concentration: NaN
constant: false
name: SLC38A1
has only substance units: false
is: Q9H2H9
is: SBO:0000252

metaR H2Otn
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110056#
reversible: true
name: H2O transport, nuclear
type: Reaction
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110056#_293c90ee_cdc5_4c4b_aee4_102481d32d36
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:8898
name: MTMR2
is: SBO:0000252
boundary condition: true
is: A6NN98
has only substance units: false
initial concentration: NaN

metaM udpgal g
is: CHEBI:58439
name: UDP-D-galactose(2-)
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
constant: false
is: HMDB00302
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR NACHEXA20ly
name: beta-N-acetylhexosaminidase A, lysosomal
is: SBO:0000176
product: MODEL1310110056#
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is described by: ECO:0000000
reactant: MODEL1310110056#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110056#_4f4553cb_8a0b_46f8_93d7_a703b17470fb
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is: Q96IJ6
name: GMPPA
initial concentration: NaN
is encoded by: hsa:29926
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_905fab4e_8032_4294_9144_9391abe482b5
is: Q8IXK2
is encoded by: hsa:79695
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: GALNT12
has only substance units: false

metaM pi e
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
name: hydrogenphosphate
initial amount: NaN
is: CHEBI:43474
is: C00009
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00973

metaM succ c
type: Species
boundary condition: false
name: Succinate
initial amount: NaN
constant: false
is: HMDB00254
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: C00042
is: CHEBI:30031
has only substance units: false

metaR r0840
type: Reaction
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.14.13.70
reversible: true
name: Free diffusion
is: SBO:0000185
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
product: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
is described by: ECO:0000000

metaM g6p c
has only substance units: false
name: D-Glucose 6-phosphate
initial amount: NaN
constant: false
is: CHEBI:61548
is: C00092
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB01401

metaR NACHEX2ly
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110056#
is: SBO:0000176
product: MODEL1310110056#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_d439a8e2_1118_4be5_9f80_716a8f69a9ba
boundary condition: true
is: SBO:0000297
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:8803
initial amount: NaN
has part: E5KS60
name: SUCLG1:SUCLA2

http://identifiers.org/biomodels.db/MODEL1310110056#_53dbadfa_109e_4969_b99a_87dc36a150c4
boundary condition: true
name: CMPK1
has only substance units: false
is encoded by: hsa:51727
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
is: B2R6S5
type: Species

metaR DOLMANP Lter
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000185
reversible: false
name: dolichol-phosphate mannose flippase (liver)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_76b01240_36fc_4306_a201_bd31740ae179
name: _AA419122_1_c
has only substance units: false
constant: false
is encoded by: hsa:AA419122
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_d187f28b_faf2_4379_8022_87ea6e10b565
is: Q9NRA2
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:26503
type: Species
has only substance units: false
name: SLC17A5
is: SBO:0000252

metaR S6T12g
fast: false
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110056#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000000
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_096c8c0e_1925_4201_a2a9_d5a852c7c149
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: SCD
has only substance units: false
type: Species
constant: false
is: O00767
is encoded by: hsa:6319

metaM ksi deg30 l
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
is: CHEBI:12936
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00143
name: keratan sulfate I, degradation product 30

metaR NBAHH ir
is: SBO:0000176
name: Nalpha-(beta-alanyl)-L-histidine hydrolase IR
fast: false
is described by: ECO:0000134
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.4.13.20
type: Reaction
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (84735.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 3.4.13.3 Confidence Level: 1 AUTHORS: PMID:4026801 NOTES:NAME Nalpha-(beta-alanyl)-L-histidine hydrolase DEFINITION Carnosine + H2O <=> beta-Alanine + L-Histidine SAB made irreversible for human
reversible: false
product: MODEL1310110056#
reactant: MODEL1310110056#

metaM dgdp m
is: HMDB00960
type: Species
is: CHEBI:58595
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
initial concentration: 1.0
name: dGDP(2-)
has only substance units: false
is: SBO:0000247

metaR CYTDK2m
product: MODEL1310110056#
reversible: false
is: SBO:0000176
name: cytidine kinase (ATP), mitochondrial
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
kinetic law: MODEL1310110056#
fast: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_829be929_3435_40de_93a1_aefc6fe40dac
type: Species
name: GALNT1
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q10472
is: SBO:0000252
constant: false
is encoded by: hsa:2589

http://identifiers.org/biomodels.db/MODEL1310110056#_8dcc3e62_880f_4552_8d26_eccbdc547dc5
type: Species
name: SLC5A7
constant: false
has only substance units: false
is: Q9GZV3
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:60482

http://identifiers.org/biomodels.db/MODEL1310110056#_e8593350_1602_4014_9407_4543655f1849
is: O75106
name: AOC2
is encoded by: hsa:314
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_ccd7267f_023d_419d_8a1a_e870ff96947f
initial amount: NaN
name: SCD5
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:79966
is: Q86SK9

metaR r0841
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.1.1.271
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
fast: false
kinetic law: MODEL1310110056#
reversible: true
name: Free diffusion
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
modifier: MODEL1310110056#
reactant: MODEL1310110056#

metaR r0733
kinetic law: MODEL1310110056#
fast: false
is: SBO:0000176
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.5.1.12
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: false
product: MODEL1310110056#
is described by: ECO:0000000
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
type: Reaction
modifier: MODEL1310110056#

metaR FAOXC184m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_e1672746_e450_4cbf_ac60_2a86e9a2d92d
initial concentration: NaN
name: PPCS
is encoded by: hsa:79717
is: SBO:0000252
is: Q9HAB8
initial amount: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false

metaR MECOAS1m
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110056#
reversible: true
modifier: MODEL1310110056#
product: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
name: mesaconate--CoA ligase (GDP-forming)

metaM pan4p m
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:47942
boundary condition: false
name: pantetheine 4'-phosphate(2-)
constant: false
initial amount: NaN
type: Species
is: HMDB01416

metaM 3decdicoa m
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
name: 3,7-decadienoylcoa
initial amount: NaN
has only substance units: false

metaR r1669
reversible: true
fast: false
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
is: SBO:0000185
product: MODEL1310110056#
reactant: MODEL1310110056#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR ACACT10m
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
is version of: http://identifiers.org/ec-code/2.3.1.9
name: acetyl-CoA C-acetyltransferase, mitochondrial
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_030cd9e6_4154_4c03_9646_bbb69729f06d
name: GNPDA1
boundary condition: true
initial concentration: NaN
is: P46926
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:10007

metaR H2Otp
fast: false
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: H2O transport, peroxisomal
product: MODEL1310110056#
reversible: true
type: Reaction

metaR VLCSp
type: Reaction
product: MODEL1310110056#
modifier: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
kinetic law: MODEL1310110056#
name: Very-long-chain-fatty-acid-CoA ligase
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
reversible: false
fast: false

metaR r0734
type: Reaction
reactant: MODEL1310110056#
reversible: false
product: MODEL1310110056#
fast: false
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110056#

metaM 44mzym r
is: CHEBI:18364
has only substance units: false
is: HMDB01286
name: 14-demethyllanosterol
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_bbb1524e_ee10_48f5_8fb1_d95fd8950085
initial amount: NaN
boundary condition: true
is encoded by: hsa:4122
name: MAN2A2
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q9P1E4
type: Species
has only substance units: false

metaM pi l
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
has only substance units: false
is: CHEBI:43474
constant: false
type: Species
is: HMDB00973
boundary condition: false

metaR 3DPHBH1
fast: false
product: MODEL1310110056#
name: Hydroxylation of 3-Decaprenyl-4-hydroxybenzoate (NADH)
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212 NOTES:Used to make Ubiquinone-10 enzyme has not been identified yet. IT
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110056#

metaM m3mpdol U c
notes: FORMULA: C1425H2340N20O370P20 CHARGE: -20
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:37632
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human uterine homolog

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaM elaid e
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
name: elaidate
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00573
is: CHEBI:30825
initial amount: NaN
constant: false
has only substance units: false

metaR r1668
fast: false
reversible: true
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110056#

metaR TCHOLAte
name: bile acid intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110056#
fast: false
reactant: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
product: MODEL1310110056#

metaM amp c
is: HMDB00045
name: AMP
notes: FORMULA: C10H12N5O7P CHARGE: -2
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:3322
initial amount: NaN
is: C00020
constant: false
is: SBO:0000247

metaM core3 g
has only substance units: false
is: CHEBI:16250
initial concentration: 1.0
constant: false
is: SBO:0000247
name: Core 3
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C16H27N2O10X CHARGE: 0

metaR ASPNATm
type: Reaction
product: MODEL1310110056#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110056#
name: aspartate N-acetyltransferase, mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.3.1.17 Confidence Level: 4 AUTHORS: PMID:11279290 NOTES:MM
kinetic law: MODEL1310110056#
reversible: false

metaR r0731
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: false
is: SBO:0000176
reactant: MODEL1310110056#
product: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000000

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaR C40CPT1
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_1b396087_43d8_4feb_9367_e192f8302aaf
is: SBO:0000252
is encoded by: hsa:10861
name: SLC26A1
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
initial concentration: NaN

metaM 3ddecdicoa m
is: HMDB03952
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: C05280
initial amount: NaN
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
name: 3,6-dodecadienoylcoa
type: Species

metaM akg e
name: 2-oxoglutarate(2-)
is: CHEBI:16810
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: HMDB00208

metaM 34hpp m
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:36242
initial concentration: 1.0
name: 3-(4-hydroxyphenyl)pyruvate
is: HMDB00707
has only substance units: false
constant: false
type: Species
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179

metaR r0587
fast: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
reactant: MODEL1310110056#
is described by: ECO:0000000
modifier: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110056#
reversible: true
type: Reaction
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1

metaM na1 c
constant: false
name: Sodium
initial concentration: 1.0
is: HMDB00588
has only substance units: false
boundary condition: false
notes: FORMULA: Na CHARGE: 1
is: C01330
initial amount: NaN
is: SBO:0000247
is: CHEBI:4541
type: Species

metaR r1667
kinetic law: MODEL1310110056#
is: SBO:0000185
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000000
fast: false
type: Reaction
name: Y+LAT2 Utilized transport

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR G14T21g
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110056#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110056#
reversible: false
reactant: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
modifier: MODEL1310110056#

metaM elaid c
is: HMDB00573
initial concentration: 1.0
name: elaidate
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:30825
type: Species

metaR r1252
reactant: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110056#
name: EC:6.2.1.3
type: Reaction
reversible: false

metaR r0732
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
product: MODEL1310110056#
is: SBO:0000176
kinetic law: MODEL1310110056#
fast: false

metaM rib D c
is: CHEBI:16988
is: HMDB00283
boundary condition: false
constant: false
type: Species
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: D-ribose

metaR r0166
type: Reaction
fast: false
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110056#
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
product: MODEL1310110056#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110056#

metaM dmnoncrn c
has only substance units: false
name: 4,8-dimethylnonanoyl carnitine
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C18H37NO4 CHARGE: 0
type: Species
is: HMDB06202

metaR ADNtm
is: SBO:0000185
reactant: MODEL1310110056#
name: adenosine facilated transport in mitochondria
reversible: true
fast: false
product: MODEL1310110056#
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110056#

metaM udpgal c
name: UDP-D-galactose(2-)
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:58439
initial concentration: 1.0
is: HMDB00302

metaR FAOXC5C5DCc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of glutaryl carnitine
type: Reaction

metaM hs deg16 l
initial amount: NaN
is: CHEBI:21338
type: Species
name: heparan sulfate, degradation product 16
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
is: HMDB02704
boundary condition: false

metaR CYSGLUexR
is: SBO:0000185
is described by: ECO:0000304
kinetic law: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110056#
name: L-cysteine/L-glutamine reversible exchanger
reactant: MODEL1310110056#

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaR ACONT
is: SBO:0000176
kinetic law: MODEL1310110056#
name: aconitase
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.3
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (3658.1) or (48.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:SMP. Biochemical
reactant: MODEL1310110056#
type: Reaction
is described by: ECO:0000134
product: MODEL1310110056#

metaR r1666
fast: false
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
reversible: true
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110056#
reactant: MODEL1310110056#

metaR GLCURtly
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
is: SBO:0000185
type: Reaction
name: glucuronate transport into lysososme
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110056#
fast: false
reactant: MODEL1310110056#
product: MODEL1310110056#

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR SPMTDe
reversible: true
is described by: ECO:0000134
product: MODEL1310110056#
name: SPMTDe
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110056#
type: Reaction
is: SBO:0000185
fast: false

metaM HC02204 c
has only substance units: false
is: CHEBI:27624
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
name: prostaglandin-b1
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_cd7842b2_ec5b_40df_89c8_f0ebdc5387c2
initial amount: NaN
is: SBO:0000252
type: Species
is: Q5HYI4
initial concentration: NaN
has only substance units: false
boundary condition: true
name: SQLE
is encoded by: hsa:6713
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_b648289a_2af6_475e_b318_3140eda8ac2e
name: PDE8A
constant: false
has only substance units: false
is encoded by: hsa:5151
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species

metaM octdececoa c
is: HMDB06351
boundary condition: false
constant: false
name: octadecenoylcoa
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM HC00591 c
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
type: Species
name: 2-oxoglutaramate
has only substance units: false
is: CHEBI:16769
initial concentration: 1.0

metaM ksii core4 pre8 g
is: CHEBI:58053
is: SBO:0000247
is: C00130
notes: FORMULA: C83H134N7O61SX CHARGE: -2
constant: false
boundary condition: false
type: Species
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 8
is: HMDB00175
initial concentration: 1.0
has only substance units: false

metaR GALASE15ly
modifier: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
reversible: false
reactant: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5

http://identifiers.org/biomodels.db/MODEL1310110056#_9fa75ddc_a5fc_428b_912d_69e5417baf0e
initial amount: NaN
is: Q9Y2A9
is: SBO:0000252
is encoded by: hsa:10331
constant: false
boundary condition: true
initial concentration: NaN
name: B3GNT3
has only substance units: false
type: Species

metaM man r
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: HMDB00169
name: D-mannose
initial amount: NaN
type: Species
constant: false
is: CHEBI:16024
initial concentration: 1.0

metaM prostgh2 r
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB01381
type: Species
name: prostaglandin H2(1-)
initial concentration: 1.0
constant: false
is: CHEBI:57405
initial amount: NaN

metaM akg c
is: HMDB00208
is: SBO:0000247
type: Species
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial concentration: 1.0
is: CHEBI:16810
constant: false
boundary condition: false
name: 2-Oxoglutarate
is: C00026
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_f2de3139_f509_45a9_8673_de9a2fd56dd7
boundary condition: true
is: SBO:0000252
has only substance units: false
name: SDR16C5
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:195814
type: Species
is: B3KT84

metaR r1665
modifier: MODEL1310110056#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110056#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110056#
name: Y+LAT2 Utilized transport
fast: false
kinetic law: MODEL1310110056#

metaR ACITL
name: ATP-Citrate lyase
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.3.3.8
product: MODEL1310110056#
is: SBO:0000176
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
modifier: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110056#

metaM na1 e
is: C01330
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: Sodium
initial concentration: 1.0
is: HMDB00588
constant: false
notes: FORMULA: Na CHARGE: 1
is: CHEBI:4541
has only substance units: false

metaR NAt3 1
product: MODEL1310110056#
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110056#
name: sodium proton antiporter (H:NA is 1:1)
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
fast: false
reactant: MODEL1310110056#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110056#_e900a68f_dd10_48ce_88e6_56a13a8b5dce
is encoded by: hsa:NM 013421
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
name: _NM_013421_1_e
type: Species

metaR RE1520M
name: RE1520
fast: false
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
modifier: MODEL1310110056#
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
product: MODEL1310110056#

metaR r1664
kinetic law: MODEL1310110056#
is: SBO:0000185
reactant: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
name: Y+LAT2 Utilized transport

metaR r2030
fast: false
product: MODEL1310110056#
reactant: MODEL1310110056#
modifier: MODEL1310110056#
reversible: false
kinetic law: MODEL1310110056#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM rib D e
initial concentration: 1.0
type: Species
is: HMDB00283
name: D-ribose
constant: false
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:16988

metaR EX alaala LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for alanylalanine
type: Reaction

metaR r0730
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110056#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110056#
kinetic law: MODEL1310110056#
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
modifier: MODEL1310110056#

metaM HC01397 x
initial amount: NaN
constant: false
is: CHEBI:27402
is: SBO:0000247
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
initial concentration: 1.0
type: Species
name: (S)-3-Hydroxyhexadecanoyl-CoA
boundary condition: false
has only substance units: false

metaM 5adtststerone e
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16330
type: Species
name: 17beta-hydroxy-5alpha-androstan-3-one
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
constant: false
has only substance units: false
is: HMDB02961

metaR RE2814R
name: RE2814
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110056#
fast: false
is: SBO:0000176

metaM C05279 m
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
name: trans,cis-Lauro-2,6-dienoyl-CoA
is: CHEBI:28387
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
is: HMDB11123
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_d2aac710_2925_4025_b48a_cf0c764216e6
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:9990
name: SLC12A6
boundary condition: true
is: Q9UHW9

metaM decdicoa c
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: decadienoylcoa
is: HMDB01168
is: SBO:0000247
constant: false
type: Species

metaM HC02204 e
constant: false
is: SBO:0000247
name: prostaglandin-b1
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27624
has only substance units: false

metaR FUMtm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
is described by: ECO:0000269
reversible: true
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
name: fumarate transport, mitochondrial

metaR PIPLCn
is described by: ECO:0000000
kinetic law: MODEL1310110056#
name: phosphatidylinositol phospholipase C, nucleus
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
reversible: false
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110056#
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.4.11
modifier: MODEL1310110056#

metaM 10fthf c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57454
is: C00234
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
constant: false
type: Species
initial amount: NaN
has only substance units: false
name: 10-Formyltetrahydrofolate
is: HMDB00972

metaR 2HBO
is described by: ECO:0000269
kinetic law: MODEL1310110056#
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
reactant: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.1.1.27
type: Reaction
product: MODEL1310110056#
fast: false

metaM pi m
is: HMDB00973
is: C00009
boundary condition: false
constant: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: hydrogenphosphate
is: CHEBI:43474

metaR SO4tl
fast: false
name: Sulfate transport (lysosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
reactant: MODEL1310110056#
is: SBO:0000185
type: Reaction
product: MODEL1310110056#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110056#

metaM dgdp c
name: dGDP
initial concentration: 1.0
boundary condition: false
is: C00361
type: Species
is: SBO:0000247
constant: false
is: HMDB00960
has only substance units: false
initial amount: NaN
is: CHEBI:58595
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361

metaM HC02023 r
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
name: Cholesterol-ester-ol
is: CHEBI:46898

metaR UMPtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.7.4.14 Confidence Level: 1 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110056#
reversible: true
name: UMP transport (ER)
reactant: MODEL1310110056#
is: SBO:0000185
product: MODEL1310110056#
type: Reaction
fast: false
is described by: ECO:0000269

metaM cit m
has only substance units: false
is: HMDB00094
is: C00158
initial amount: NaN
type: Species
is: CHEBI:16947
name: Citrate
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: SBO:0000247

metaM 3hexdcoa c
type: Species
is: SBO:0000247
is: C05258
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
initial concentration: 1.0
is: HMDB03932
name: 3-hydroxyhexadecanoylcoa
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false

metaM 5adtststerone c
initial concentration: 1.0
is: HMDB02961
initial amount: NaN
is: SBO:0000247
is: CHEBI:16330
name: 17beta-hydroxy-5alpha-androstan-3-one
type: Species
has only substance units: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
constant: false
boundary condition: false

metaR r1662
type: Reaction
is: SBO:0000185
reactant: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110056#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR XYLt
product: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
reversible: true
reactant: MODEL1310110056#
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
name: D-xylose reversible transport

metaR LGNCt
name: fatty acid transport via diffusion
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000
product: MODEL1310110056#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
type: Reaction

metaM pi n
initial amount: NaN
has only substance units: false
name: hydrogenphosphate
is: CHEBI:43474
is: HMDB00973
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_34540e41_7eab_4113_b64f_7d50c21896bd
has only substance units: false
name: GNPDA2
is: Q8TDQ7
is encoded by: hsa:132789
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
constant: false

metaR HSD17B4x
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
product: MODEL1310110056#
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110056#
name: hydroxysteroid (17-beta) dehydrogenase 4
fast: false

metaR ORNt3m
is described by: ECO:0000269
reversible: true
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
name: ornithine mitochondrial transport via proton antiport
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#

metaR S6TASE5ly
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
type: Reaction
name: N-acetylgalactosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110056#
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
is: SBO:0000176
reversible: true

metaR EX 1glyc hs LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1 acyl phosphoglycerol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_731286fe_0505_4220_82c7_9b678a990b2b
is encoded by: hsa:80025
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q6P1K9
name: PANK2
constant: false
has only substance units: false
is: SBO:0000252
type: Species

metaR RE3006M
type: Reaction
name: RE3006
is: SBO:0000176
kinetic law: MODEL1310110056#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000

metaR LEUKTRA4t
type: Reaction
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
is: SBO:0000185
name: leukotriene A4 transport
reversible: true
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#

metaR PAIL45P HStn
is: SBO:0000185
fast: false
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
reversible: true
kinetic law: MODEL1310110056#
is described by: ECO:0000000
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110056#
type: Reaction

metaM c101crn c
name: decenoyl carnitine
type: Species
initial concentration: 1.0
notes: FORMULA: C17H31NO4 CHARGE: 0
is: SBO:0000247
is: HMDB13205
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_e6b99723_0a50_47fd_b6ef_6ef2588f97d5
is encoded by: hsa:2987
is: Q16774
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
name: GUK1
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_04693758_05b1_425c_b95e_6c6647349b04
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
name: SLC5A9
is encoded by: hsa:200010
constant: false
initial amount: NaN
has only substance units: false
is: E9PAK4

metaR r1660
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110056#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110056#

metaM mal L c
is: CHEBI:15589
is: HMDB00156
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
name: (S)-malate(2-)

http://identifiers.org/biomodels.db/MODEL1310110056#_bde1161e_b575_4d86_bc63_09feb8fe15ed
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is: F5GWS5
has only substance units: false
boundary condition: true
name: ADCY10
is encoded by: hsa:55811
type: Species

metaR r1682
is described by: ECO:0000000
reactant: MODEL1310110056#
type: Reaction
fast: false
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
product: MODEL1310110056#
is: SBO:0000185
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#

metaM apoC Lys c
initial amount: NaN
has only substance units: false
is: HMDB00182
constant: false
is: CHEBI:32551
is: SBO:0000247
name: Apocarboxylase (Lys residue)
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C6H13N2OX CHARGE: 0

metaM mal L e
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00156
has only substance units: false
is: CHEBI:15589
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
name: (S)-malate(2-)
boundary condition: false
initial concentration: 1.0

metaM succ m
initial concentration: 1.0
is: HMDB00254
name: Succinate
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
has only substance units: false
is: CHEBI:30031
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: C00042
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_05613eaa_baa9_49ed_8d16_2a660e160ece
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3612
constant: false
name: IMPA1
initial amount: NaN
is: B7Z6Q4
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_629bc312_5335_494f_834a_478f3dbee6d2
name: ALPI
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:248
is: SBO:0000252
initial amount: NaN
is: P09923
constant: false

metaR r1661
type: Reaction
reversible: true
fast: false
product: MODEL1310110056#
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR r0729
product: MODEL1310110056#
is: SBO:0000176
reactant: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110056#
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false

metaR FUMAC
reversible: false
modifier: MODEL1310110056#
is: SBO:0000176
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
name: fumarylacetoacetase
is version of: http://identifiers.org/ec-code/3.7.1.2
reactant: MODEL1310110056#
fast: false
product: MODEL1310110056#
type: Reaction
is described by: ECO:0000269

metaR CITL
product: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
modifier: MODEL1310110056#
is: SBO:0000176
reactant: MODEL1310110056#
name: Citrate lyase
type: Reaction
kinetic law: MODEL1310110056#
reversible: false
is described by: ECO:0000000

metaM pi r
initial concentration: 1.0
is: C00009
has only substance units: false
is: HMDB00973
name: hydrogenphosphate
initial amount: NaN
is: SBO:0000247
is: CHEBI:43474
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_a2690866_6749_4b50_a55c_08eccca8f926
type: Species
is encoded by: hsa:6487
constant: false
name: ST3GAL3
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_e9b529fb_3aee_4dd8_bbbe_7bfc8d773985
type: Species
is encoded by: hsa:2098
is: P10768
initial concentration: NaN
name: ESD
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false

metaR L LACt4r
fast: false
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
is: SBO:0000185
name: L-lactate reversible transport via sodium symport
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#

metaM pep c
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
boundary condition: false
is: HMDB00263
is: C00074
has only substance units: false
type: Species
name: Phosphoenolpyruvate
is: CHEBI:18021
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_1f43b8c2_8a24_41e1_8812_2495396b7f86
name: TM7SF2
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: O76062
has only substance units: false
is: SBO:0000252
is encoded by: hsa:7108
boundary condition: true

metaR RE2972M
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
name: RE2972
modifier: MODEL1310110056#
is: SBO:0000176
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.1.67
product: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#

metaM c101crn e
name: decenoyl carnitine
type: Species
initial concentration: 1.0
is: HMDB13205
is: SBO:0000247
notes: FORMULA: C17H31NO4 CHARGE: 0
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false

metaM ps hs e
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:18303
name: phosphatidylserine
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
is: SBO:0000247
type: Species
constant: false
boundary condition: false

metaR r1684
reactant: MODEL1310110056#
type: Reaction
reversible: false
name: Y+LAT2 Utilized transport
product: MODEL1310110056#
modifier: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110056#

metaR r0728
is: SBO:0000176
reversible: true
product: MODEL1310110056#
fast: false
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#

metaR r0580
type: Reaction
product: MODEL1310110056#
is described by: ECO:0000000
modifier: MODEL1310110056#
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.7
reversible: true
fast: false
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:

metaM 3hddcoa c
is: HMDB00623
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
has only substance units: false
name: (S)-3-Hydroxydodecanoyl-CoA
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
boundary condition: false
initial amount: NaN

metaR FAOXC226m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_14e1e903_5079_4d27_9e3b_6e35afe643b2
boundary condition: true
type: Species
is: E5KSL5
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:1716
is: SBO:0000252
name: DGUOK
initial concentration: NaN

metaR PLA2 2e
type: Reaction
is: SBO:0000176
name: phospholipase A2
reversible: false
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5322.1) or (5319.1) or (81579.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (30814.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:10455175,PMID:10681567,PMID:11031251,PMID:11112443,PMID:8300559,PMID:9188469,PMID:9272153,PMID:9886417 NOTES:phosphatidyl choline degradation NJ
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.4

metaM hs deg7 l
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
name: heparan sulfate, degradation product 7
constant: false
is: HMDB06210
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
has only substance units: false
initial concentration: 1.0

metaM estradiol c
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00151
boundary condition: false
initial amount: NaN
name: estradiol
is: CHEBI:16469
type: Species
has only substance units: false
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951

metaR EX CE1925 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3'-carboxy-alpha-chromanol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_6eac8ca2_ecd9_431e_8a8f_7b3b2347be9e
constant: false
initial amount: NaN
is: Q92781
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5959
is: SBO:0000252
name: RDH5

metaR r0727
product: MODEL1310110056#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000000
type: Reaction

metaM pi x
has only substance units: false
is: CHEBI:43474
name: hydrogenphosphate
is: HMDB00973
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false

metaR r2139
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110056#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
product: MODEL1310110056#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110056#
reactant: MODEL1310110056#

metaM dolglcp U r
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:15812
initial amount: NaN
has only substance units: false
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
boundary condition: false

metaR CHSTEROLtrc
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
type: Reaction
kinetic law: MODEL1310110056#
is described by: ECO:0000134
product: MODEL1310110056#
name: transport of cholesterol into the cytosol
is: SBO:0000185
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110056#_c0854c8f_67c9_4d71_b580_933a0621cb61
type: Species
boundary condition: true
is: SBO:0000252
name: _AW277253_1_c
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AW277253

metaM 3hexdcoa m
type: Species
has only substance units: false
is: HMDB03932
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
constant: false
name: 3-hydroxyhexadecanoylcoa
is: C05258

metaR r0437
is version of: http://identifiers.org/ec-code/4.1.2.13
is described by: ECO:0000000
modifier: MODEL1310110056#
is: SBO:0000176
fast: false
reactant: MODEL1310110056#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
type: Reaction
product: MODEL1310110056#
reversible: true
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110056#_783df3f4_3af6_4dbc_a79f_0ca50dc14393
name: CBS
initial concentration: NaN
is encoded by: hsa:875
type: Species
has only substance units: false
is: Q9NTF0
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true

metaM ps hs c
type: Species
name: ps_hs[c]
initial amount: NaN
is: CHEBI:18303
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_a76ca20c_76ad_457e_b78c_7b9763c123aa
boundary condition: true
type: Species
is encoded by: hsa:79751
has only substance units: false
is: SBO:0000252
name: SLC25A22
constant: false
is: Q9H936
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_9e36d808_8526_4ded_9b5f_eec8eb80e71b
type: Species
is encoded by: hsa:6576
name: SLC25A1
initial concentration: NaN
is: D9HTE9
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR CHLtm
type: Reaction
name: choline transport via diffusion (cytosol to mitochondria)
kinetic law: MODEL1310110056#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
fast: false

metaR r0726
reactant: MODEL1310110056#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110056#
product: MODEL1310110056#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is version of: http://identifiers.org/ec-code/2.7.1.33
fast: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaM 10fthf m
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
name: 10-formyltetrahydrofolate(2-)
is: CHEBI:57454
boundary condition: false
has only substance units: false
is: HMDB00972
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species

metaM dgchol c
is: HMDB00637
has only substance units: false
is: CHEBI:36252
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: SBO:0000247
name: glycochenodeoxycholate
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
type: Species

metaM estradiol e
constant: false
is: HMDB00151
has only substance units: false
is: SBO:0000247
is: CHEBI:16469
initial amount: NaN
initial concentration: 1.0
type: Species
name: estradiol
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_b631600a_bc16_4a25_9cb8_c397392f0176
initial amount: NaN
is: O43708
name: GSTZ1
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2954
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_f3a6706a_2677_4823_a0ff_a995883ab9a1
initial concentration: NaN
is: Q9NPH0
initial amount: NaN
constant: false
is encoded by: hsa:51205
type: Species
has only substance units: false
is: SBO:0000252
name: ACP6
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_b8c91979_88c8_41c8_99c6_f5148b2aa1d5
has only substance units: false
type: Species
constant: false
name: ADCY6
is encoded by: hsa:112
is: SBO:0000252
is: O43306
initial amount: NaN
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_43488c68_91a8_4057_85d9_baa34add1957
initial concentration: NaN
name: _H77542_1_r
initial amount: NaN
is encoded by: hsa:H77542
is: SBO:0000252
constant: false
type: Species
boundary condition: true
has only substance units: false

metaR FAOXC18C18OHm
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18-->C18OH)m
type: Reaction

metaM g6p r
is: CHEBI:61548
boundary condition: false
constant: false
is: C00092
type: Species
is: SBO:0000247
name: D-Glucose 6-phosphate
has only substance units: false
is: HMDB01401
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
initial amount: NaN
initial concentration: 1.0

metaM citr L m
is: CHEBI:16349
boundary condition: false
is: HMDB00904
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: L-citrulline
type: Species
constant: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277

metaM ump n
boundary condition: false
constant: false
is: SBO:0000247
name: UMP(2-)
initial concentration: 1.0
is: HMDB00288
is: CHEBI:57865
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

metaM HC02217 e
constant: false
type: Species
has only substance units: false
name: prostaglandin-g2
initial amount: NaN
is: CHEBI:27647
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
boundary condition: false

metaR r2352
reactant: MODEL1310110056#
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110056#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport

metaM tsul c
name: thiosulfate(2-)
initial amount: NaN
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
boundary condition: false
type: Species
has only substance units: false
constant: false
is: HMDB00257
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16094

http://identifiers.org/biomodels.db/MODEL1310110056#_c5c3f529_5850_4031_aa0f_0e31eada7ebf
constant: false
is: Q96C36
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: PYCR2
is encoded by: hsa:29920
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_425eb213_fede_449b_bbbb_8d842bd070c1
name: PIP5K1A
constant: false
is encoded by: hsa:8394
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q99755

metaR PI4PP
reversible: false
name: phosphatidylinositol-4-phosphate 4-phosphatase
is: SBO:0000176
reactant: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2425833 NOTES:NCD
type: Reaction
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_3fad12f1_f1d3_42d9_a8d5_5f1a440c4681
is: SBO:0000252
has only substance units: false
is encoded by: hsa:113026
is: Q8N3E9
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
name: PLCD3
boundary condition: true

metaM thcholstoic x
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: CHEBI:18402
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
constant: false
initial concentration: 1.0
type: Species
is: HMDB03873
initial amount: NaN

metaR r1800
is: SBO:0000185
type: Reaction
product: MODEL1310110056#
is described by: ECO:0000000
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: false

metaM ump r
has only substance units: false
is: CHEBI:57865
is: HMDB00288
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
name: UMP
constant: false

metaR EX thym LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymine exchange
type: Reaction

metaR r2024
is described by: ECO:0000000
modifier: MODEL1310110056#
reversible: false
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false

metaR r2137
fast: false
modifier: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reversible: true

metaR r0584
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
reversible: true
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
reactant: MODEL1310110056#
product: MODEL1310110056#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_b7f063bc_d40c_4211_a8d8_4bd51c97edf3
boundary condition: true
is: SBO:0000252
is: P48448
name: ALDH3B2
is encoded by: hsa:222
initial concentration: NaN
type: Species
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_adb93aa1_a4bd_41a1_8611_6804bd49c59f
is: A8K3J4
type: Species
is encoded by: hsa:23632
is: SBO:0000252
boundary condition: true
has only substance units: false
name: CA14
initial amount: NaN
initial concentration: NaN
constant: false

metaR r0724
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reactant: MODEL1310110056#
is: SBO:0000176
modifier: MODEL1310110056#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.33
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:

metaR r2353
reversible: true
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110056#
is: SBO:0000185
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110056#

metaM dmnoncrn x
has only substance units: false
initial amount: NaN
notes: FORMULA: C18H37NO4 CHARGE: 0
name: 4,8-dimethylnonanoyl carnitine
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB06202
initial concentration: 1.0
constant: false

metaR SPHINGStl
is described by: ECO:0000000
kinetic law: MODEL1310110056#
name: sphingosine intracellular transport
reactant: MODEL1310110056#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however sphingosine manages to get in different compartments of cells. NOT presumed to be flip-flop. NJ
reversible: true
product: MODEL1310110056#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_ee8e0489_56d4_49ba_968b_cfce99e577e2
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:7498
has only substance units: false
name: XDH
boundary condition: true
is: SBO:0000252
is: P47989

http://identifiers.org/biomodels.db/MODEL1310110056#_f2515d81_c2a9_4244_ba7b_9f103581ed13
is encoded by: hsa:8398
is: SBO:0000252
has only substance units: false
is: O60733
type: Species
initial amount: NaN
initial concentration: NaN
name: PLA2G6
boundary condition: true
constant: false

metaR r1801
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
reversible: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
product: MODEL1310110056#
is: SBO:0000185
fast: false

metaR HEXDCRNe
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecanoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_8af55545_01bd_4d67_9e32_b255726bab0d
type: Species
is encoded by: hsa:171425
is: SBO:0000252
initial concentration: NaN
is: Q8N0X4
initial amount: NaN
constant: false
name: CLYBL
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_02e4b77a_92fa_4813_9ac1_874af48b1e5f
is: SBO:0000252
has only substance units: false
type: Species
is: P17812
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1503
name: CTPS1

metaM adrncoa m
type: Species
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205480
is: C16170
name: adrenyl coenzyme A
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247

metaM HC02217 c
type: Species
has only substance units: false
constant: false
name: prostaglandin-g2
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial amount: NaN
is: CHEBI:27647
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR r2354
is: SBO:0000185
product: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110056#
fast: false
reversible: true
reactant: MODEL1310110056#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_0848ccee_6f44_4f66_bfb5_95786c6cbf3d
initial amount: NaN
is: Q14435
boundary condition: true
is encoded by: hsa:2591
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
name: GALNT3

metaM cys L e
boundary condition: false
name: L-cysteine
has only substance units: false
constant: false
type: Species
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
initial amount: NaN
is: HMDB00574
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17561

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

metaR r0723
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
is version of: http://identifiers.org/ec-code/2.3.1.41
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000176
fast: false
modifier: MODEL1310110056#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
reversible: false
reactant: MODEL1310110056#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_dbe87a85_7aab_4195_bbfd_ac9d4b72a986
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
name: FH
type: Species
is: P07954
is encoded by: hsa:2271

metaR r0835
reactant: MODEL1310110056#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110056#
reversible: true
is: SBO:0000185
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_fd129256_a236_422f_a5a1_eb039c313cd5
is encoded by: hsa:65263
initial concentration: NaN
initial amount: NaN
name: PYCRL
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q53H96

metaR r2355
kinetic law: MODEL1310110056#
fast: false
product: MODEL1310110056#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110056#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_8c68a062_048c_4aee_a37d_8a70e2151856
name: HADHB
is encoded by: hsa:3032
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P55084
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_151f2a8c_b594_4011_a48d_307a40f276fe
is encoded by: hsa:5091
initial amount: NaN
name: PC
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
has only substance units: false

metaM 4hphac c
boundary condition: false
has only substance units: false
constant: false
name: 4-hydroxyphenylacetate
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
type: Species
initial concentration: 1.0
is: CHEBI:48999
initial amount: NaN
is: HMDB00020
is: SBO:0000247

metaR UAG4E
reversible: true
fast: false
modifier: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/5.1.3.2
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110056#
name: UDP-N-acetylglucosamine 4-epimerase

http://identifiers.org/biomodels.db/MODEL1310110056#_5ccda972_77d3_4bda_bde6_63bc99d09a25
type: Species
name: SLC2A12
initial amount: NaN
is: SBO:0000252
is: Q8TD20
has only substance units: false
is encoded by: hsa:154091
boundary condition: true
constant: false
initial concentration: NaN

metaM ac m
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial concentration: 1.0
name: acetate
is: CHEBI:30089
constant: false
boundary condition: false
is: HMDB00042

metaM pep m
is: CHEBI:18021
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00263
is: C00074
boundary condition: false
name: Phosphoenolpyruvate
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
is: SBO:0000247

metaR DNDPt17m
fast: false
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
modifier: MODEL1310110056#
name: dUDP transport via dCDP antiport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110056#_6417a609_dc61_47bc_8c11_0b4c0f24b72d
constant: false
has only substance units: false
is encoded by: hsa:51292
boundary condition: true
initial concentration: NaN
name: GMPR2
type: Species
is: Q9P2T1
is: SBO:0000252
initial amount: NaN

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_93cc96b0_91c1_45a1_9f42_a22edd90a59b
is: SBO:0000252
is encoded by: hsa:10050
initial amount: NaN
constant: false
is: Q9Y2C5
name: SLC17A4
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR r0834
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
modifier: MODEL1310110056#
fast: false
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.5.4.16
kinetic law: MODEL1310110056#

metaM akg x
type: Species
is: SBO:0000247
is: HMDB00208
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
name: 2-oxoglutarate(2-)
initial amount: NaN
is: CHEBI:16810
initial concentration: 1.0

metaR MECOALm
is version of: http://identifiers.org/ec-code/6.2.1.4
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
fast: false
reactant: MODEL1310110056#
is described by: ECO:0000212
is: SBO:0000176
modifier: MODEL1310110056#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/6.2.1.5
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_834fb636_3aa1_4191_85c4_ea010111efa5
boundary condition: true
initial amount: NaN
has only substance units: false
name: SLC7A10
is: Q9NS82
is encoded by: hsa:56301
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252

metaR r2356
kinetic law: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
fast: false
reversible: true

metaM cys L c
type: Species
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
name: L-cysteine
boundary condition: false
is: CHEBI:17561
is: SBO:0000247
is: HMDB00574

http://identifiers.org/biomodels.db/MODEL1310110056#_fef2895f_b830_4d6d_a50c_e66f7e97201f
constant: false
boundary condition: true
initial amount: NaN
is: O75355
name: ENTPD3
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:956
is: SBO:0000252

metaR GLNASNNaEx
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110056#
name: L-glutamine/L-asparagine Na-dependent exchange (Gln-L in)
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
product: MODEL1310110056#
modifier: MODEL1310110056#
reactant: MODEL1310110056#

metaM hexde7coa x
initial amount: NaN
initial concentration: 1.0
is: HMDB02288
name: 7-hexadecenoylcoa
constant: false
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4

metaM na1 r
type: Species
constant: false
has only substance units: false
is: HMDB00588
initial amount: NaN
boundary condition: false
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
is: CHEBI:29101
name: sodium(1+)
is: SBO:0000247
initial concentration: 1.0

metaM dgdp n
name: dGDP(2-)
initial concentration: 1.0
is: CHEBI:58595
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
constant: false
initial amount: NaN
is: HMDB00960
has only substance units: false

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaM CE1925 e
name: 3'-carboxy-alpha-chromanol
initial amount: NaN
is: CHEBI:57923
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C16H21O4 CHARGE: -1 INCHI: InChI=1/C16H22O4/c1-9-10(2)15-12(11(3)14(9)19)5-7-16(4,20-15)8-6-13(17)18/h19H,5-8H2,1-4H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1925
has only substance units: false
is: SBO:0000247
constant: false

metaM succ e
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
initial concentration: 1.0
name: succinate(2-)
boundary condition: false
is: CHEBI:30031
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB00254
initial amount: NaN

metaR NH4tn
kinetic law: MODEL1310110056#
is described by: ECO:0000000
product: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
reversible: true
name: ammonia nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110056#_5d0279cc_1639_43c8_a3fe_97e126bc4d80
name: _W87865_1_c
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:W87865
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species

metaM tddedi2coa m
initial amount: NaN
has only substance units: false
name: trans2,6dodecadienoylcoa
type: Species
is: SBO:0000247
initial concentration: 1.0
is: C08277
is: HMDB00792
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
constant: false

metaR EX c5dc
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glutaryl carnitine
type: Reaction

metaR TMNDNCCRNt
reversible: false
is: SBO:0000185
type: Reaction
modifier: MODEL1310110056#
name: transport into the mitochondria (carnitine)
reactant: MODEL1310110056#
is described by: ECO:0000000
product: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false

metaM dopasf c
is: CHEBI:37946
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
name: dopamine 3-O-sulfate
initial amount: NaN
is: HMDB06275
boundary condition: false
has only substance units: false
constant: false
type: Species

metaM HC01162 c
initial amount: NaN
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: CHEBI:58376
has only substance units: false
boundary condition: false

metaR r2357
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
reversible: true
type: Reaction

metaM cs a l
initial concentration: 1.0
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
is: HMDB02183
type: Species
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:36005
is: SBO:0000247
constant: false

metaR FAOXC204C205x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C20:5)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_a835a6a5_3fae_4ff6_a2cf_8f70727e2fc5
has only substance units: false
is encoded by: hsa:2686
boundary condition: true
name: GGT7
constant: false
type: Species
is: A0PJJ9
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM dd2coa x
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: SBO:0000247
has only substance units: false
is: CHEBI:57330
is: HMDB03712
name: trans-Dodec-2-enoyl-CoA

metaR TPI
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
kinetic law: MODEL1310110056#
reversible: true
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110056#
is: SBO:0000176
fast: false
name: triose-phosphate isomerase
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/5.3.1.1

metaM ps hs m
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
boundary condition: false
type: Species
name: ps_hs[m]
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:18303

metaR r2133
modifier: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
reversible: true
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110056#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110056#

metaM Lcystin c
boundary condition: false
is: CHEBI:16283
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
name: L-cystine
constant: false
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00192
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_74ac6a94_5663_4f68_8f1d_db0c2e4c9860
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
constant: false
name: _AU149534_1_m
is encoded by: hsa:AU149534
is: SBO:0000252
initial amount: NaN

metaR C161CRN2t
product: MODEL1310110056#
type: Reaction
is described by: ECO:0000269
reversible: false
fast: false
name: C161 transport into the mitochondria
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110056#_6500c2a4_01fb_4f17_b1ef_3ab4a3082ef3
boundary condition: true
is encoded by: hsa:4706
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is: O14561
type: Species
initial amount: NaN
name: NDUFAB1

metaM octdececoa m
name: octadecenoylcoa
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/5280355
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4

metaR r2028
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110056#
is described by: ECO:0000000
modifier: MODEL1310110056#

metaR 3AIB Dtm
name: transport of 3aib_D into mitochondria
fast: false
is described by: ECO:0000134
reactant: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:
is: SBO:0000185
product: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction

metaR AKR1C41
modifier: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.1.1.225
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110056#
type: Reaction
is: SBO:0000176

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

metaR GLU5Km
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 2.7.2.11 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.2.1.41
is described by: ECO:0000254
is: SBO:0000176
type: Reaction
reactant: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#
name: glutamate 5-kinase (m)
reversible: false

metaR LAPCOAl
reactant: MODEL1310110056#
name: lysosomal acid phosphorylase (CoA)
reversible: false
notes: GENE_ASSOCIATION: (53.1) SUBSYSTEM: CoA catabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:11923312,PMID:11994049 NOTES:IT. human enzymes overexpressed on E.coli, Pig Liver
is version of: http://identifiers.org/ec-code/3.1.3.2
kinetic law: MODEL1310110056#
product: MODEL1310110056#
fast: false
modifier: MODEL1310110056#
type: Reaction
is described by: ECO:0000304
is: SBO:0000176

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaR NH4tp
reactant: MODEL1310110056#
name: ammonia peroxisomal transport
kinetic law: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110056#
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000

metaR FUM
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110056#
is described by: ECO:0000000
kinetic law: MODEL1310110056#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.2
name: fumarase
reactant: MODEL1310110056#
modifier: MODEL1310110056#
type: Reaction

metaM tsul m
name: thiosulfate(2-)
is: HMDB00257
is: SBO:0000247
type: Species
is: CHEBI:16094
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial concentration: 1.0
has only substance units: false

metaM ksi deg24 l
has only substance units: false
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:12936
is: HMDB00143
initial amount: NaN
name: keratan sulfate I, degradation product 24

metaM 3hddcoa m
is: HMDB11123
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
type: Species
name: (S)-3-Hydroxydodecanoyl-CoA
is: C05279
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR r0434
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
is: SBO:0000176
modifier: MODEL1310110056#
fast: false
type: Reaction
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: true
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_03f6f7a3_0e07_4e6f_8e92_a73039fba894
type: Species
is: SBO:0000252
name: ALDH3A1
is: P30838
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:218
boundary condition: true

metaM dopasf e
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
is: HMDB06275
name: dopamine 3-O-sulfate
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:37946
type: Species

metaR AKR1C42
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
product: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110056#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.225
fast: false
type: Reaction
kinetic law: MODEL1310110056#

metaR DHCRD2
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110056#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
product: MODEL1310110056#
modifier: MODEL1310110056#
reactant: MODEL1310110056#
name: dihydroceramide desaturase

metaM HC00591 m
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:16769
has only substance units: false
name: 2-oxoglutaramate
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940

http://identifiers.org/biomodels.db/MODEL1310110056#_ed0bc561_13a9_4f28_a125_75e5ac648be6
is encoded by: hsa:10841
type: Species
is: SBO:0000252
is: O95954
name: FTCD
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true

metaR r2358
is: SBO:0000185
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110056#
reversible: true
fast: false
product: MODEL1310110056#
type: Reaction
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110056#_c5652429_db93_417f_a9fa_c88bf5725761
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4722
is: O75489
name: NDUFS3
has only substance units: false
type: Species

metaR r2131
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
reversible: true
kinetic law: MODEL1310110056#
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

metaM btcoa c
name: Butanoyl-CoA
constant: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
initial concentration: 1.0
initial amount: NaN
is: HMDB01088
is: CHEBI:57371
is: SBO:0000247
is: C00136
type: Species
has only substance units: false
boundary condition: false

metaR r0839
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.3.1.70
product: MODEL1310110056#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
reactant: MODEL1310110056#
name: Postulated transport reaction
modifier: MODEL1310110056#
fast: false

metaM xol7aone c
has only substance units: false
type: Species
is: CHEBI:17899
boundary condition: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: 7alpha-hydroxycholest-4-en-3-one
constant: false
is: HMDB01993

metaM dhdascb e
is: SBO:0000247
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
is: CHEBI:58070
boundary condition: false
name: dehydroascorbide(1-)
is: HMDB01264
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_5999ac39_2060_442a_a728_9fd7e7f1de0d
initial concentration: NaN
is: P35270
is encoded by: hsa:6697
type: Species
name: SPR
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252

metaM lnlncg c
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: HMDB03073
name: gamma-linolenate
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:32391
is: SBO:0000247
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_b02c733d_3b0e_4a3e_a35a_da6d64959333
is: Q8TF71
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:117247
boundary condition: true
has only substance units: false
name: SLC16A10
initial concentration: NaN

metaR r2359
reversible: true
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM hestratriol e
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
constant: false
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
name: 4,17 dihydroxy estradiol
is: HMDB05896
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_f0c2f628_0525_42ec_9a6f_a620e2d0ea62
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6582
is: O15244
is: SBO:0000252
constant: false
name: SLC22A2
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_72202365_c397_4987_893f_9e4c47454c59
has only substance units: false
is: P51570
initial concentration: NaN
is encoded by: hsa:2584
is: SBO:0000252
name: GALK1
type: Species
boundary condition: true
initial amount: NaN
constant: false

metaR r2132
product: MODEL1310110056#
is: SBO:0000185
kinetic law: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR FACOAL80i
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase (octanoate)
reactant: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3

metaM 5pmev c
initial amount: NaN
is: SBO:0000247
name: (R)-5-phosphonatomevalonate(3-)
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1
has only substance units: false
constant: false
is: HMDB01343

metaR ANTHte
name: Transport of anthranilate
reversible: true
reactant: MODEL1310110056#
is described by: ECO:0000134
product: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110056#
fast: false
type: Reaction

metaR r0838
reactant: MODEL1310110056#
reversible: true
kinetic law: MODEL1310110056#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110056#
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.2.4
is: SBO:0000185
name: Free diffusion
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110056#_aca964f4_6b40_4fd8_9f73_97f451a9141c
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2806
name: GOT2
constant: false
is: P00505
has only substance units: false
type: Species
is: SBO:0000252

metaM HC00229 e
is: CHEBI:28189
initial amount: NaN
boundary condition: false
name: Isomaltose
is: SBO:0000247
constant: false
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
has only substance units: false
initial concentration: 1.0
type: Species

metaM citr L e
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: HMDB00904
name: citr_L[e]
boundary condition: false
is: CHEBI:16349
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaM chtn e
is: SBO:0000247
initial amount: NaN
is: CHEBI:17029
initial concentration: 1.0
name: chitin
boundary condition: false
has only substance units: false
type: Species
is: HMDB03362
constant: false
notes: FORMULA: C24H41N3O16 CHARGE: 0 INCHI: InChI=1S/C24H41N3O16/c1-7(31)25-13-18(36)20(11(5-29)39-22(13)38)42-24-15(27-9(3)33)19(37)21(12(6-30)41-24)43-23-14(26-8(2)32)17(35)16(34)10(4-28)40-23/h10-24,28-30,34-38H,4-6H2,1-3H3,(H,25,31)(H,26,32)(H,27,33)/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+,24+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02118

metaM lneldc e
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: HMDB06270
name: linoelaidic acid (all trans C18:2)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_4ce77b9a_4665_4c4d_b586_a3fb07cc3a37
boundary condition: true
is encoded by: hsa:AI222095
initial amount: NaN
has only substance units: false
name: _AI222095_1_e
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaM apoC Lys btn m
notes: FORMULA: C16H27N4O3SX CHARGE: 0
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7886
type: Species
is: HMDB03134
has only substance units: false
initial amount: NaN
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: C05552
is: SBO:0000247
boundary condition: false

metaR EX 3octdece1crn
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-octadecenoyl carnitine
type: Reaction

metaM adrncoa x
is: SBO:0000247
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
constant: false
is: C16170
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205480
name: adrenyl coenzyme A
type: Species

metaM CE0785 m
initial amount: NaN
boundary condition: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
has only substance units: false
constant: false
name: cis,cis-myristo-5,8-dienoyl-CoA
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:57795

metaR SERtN1
product: MODEL1310110056#
is described by: ECO:0000269
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
name: Serine transport (Na, H coupled)
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_ef116594_5905_4ff7_b87c_0154f4b23427
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
name: ALG3
type: Species
has only substance units: false
is encoded by: hsa:10195
boundary condition: true

metaM 4hphac e
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
is: SBO:0000247
name: 4-hydroxyphenylacetate
is: HMDB00020
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:48999

metaM CE4793 x
is: CHEBI:57923
initial amount: NaN
name: 3-oxo-dihomo-gama-linolenoyl-CoA
type: Species
constant: false
notes: FORMULA: C41H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29(49)24-32(51)70-23-22-43-31(50)20-21-44-39(54)36(53)41(2,3)26-63-69(60,61)66-68(58,59)62-25-30-35(65-67(55,56)57)34(52)40(64-30)48-28-47-33-37(42)45-27-46-38(33)48/h8-9,11-12,14-15,27-28,30,34-36,40,52-53H,4-7,10,13,16-26H2,1-3H3,(H,43,50)(H,44,54)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/b9-8-,12-11-,15-14-/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4793
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR ARACHDCOAtx
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
name: fatty acid intracellular transport
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
fast: false

metaR DURIt
is described by: ECO:0000000
kinetic law: MODEL1310110056#
fast: false
name: deoxyuridine transport via diffusion
product: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reversible: true
type: Reaction

metaM zymst r
name: zymosterol
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
initial concentration: 1.0
is: HMDB06271
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: CHEBI:18252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_11dc4c37_a896_4b94_af0b_e6af07eab32c
name: HMGCS2
type: Species
is encoded by: hsa:3158
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is: P54868
initial concentration: NaN
initial amount: NaN

metaR GALASE7ly
is: SBO:0000176
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110056#
reactant: MODEL1310110056#
fast: false
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
kinetic law: MODEL1310110056#

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

metaM hpdcacoa m
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB06497
constant: false
is: SBO:0000247
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
name: heptadecanoyl coa
has only substance units: false

metaM citr L c
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:16349
constant: false
is: HMDB00904
has only substance units: false
name: L-citrulline
initial amount: NaN

metaM lnlncg e
is: HMDB03073
constant: false
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
name: gamma-linolenate
has only substance units: false
is: CHEBI:32391
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_6674d384_d875_4231_9237_df142b3b7355
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: Q7KYS4
name: PDE4C
is encoded by: hsa:5143
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_0a9e0ae1_64a7_4bf6_b0df_ebd146582952
has only substance units: false
is: SBO:0000252
is: Q16718
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:4698
name: NDUFA5
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_43865cdc_107c_43f3_a743_e39b65abddf1
is: SBO:0000252
initial concentration: NaN
is: P49914
name: MTHFS
initial amount: NaN
is encoded by: hsa:10588
type: Species
has only substance units: false
boundary condition: true
constant: false

metaM hestratriol c
is: HMDB05896
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
name: 4,17 dihydroxy estradiol
is: SBO:0000247
has only substance units: false
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
constant: false

metaM mlthf c
is: C00143
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: SBO:0000247
has only substance units: false
name: 5,10-Methylenetetrahydrofolate
is: CHEBI:15636
is: HMDB01533
type: Species
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR r2130
product: MODEL1310110056#
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_d51716d3_a592_4531_b8fe_47dcb4577ccc
name: _AD000092_1_c
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:AD000092
boundary condition: true

metaR ACOAO7p
is version of: http://identifiers.org/ec-code/1.3.3.6
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
product: MODEL1310110056#
reversible: false
modifier: MODEL1310110056#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000269

metaM lneldc c
is: SBO:0000247
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
name: linoelaidic acid (all trans C18:2)
is: HMDB06270
type: Species

metaR G14T10g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110056#
is described by: ECO:0000000
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_784ea723_b920_4130_afaa_509c7c29ae24
is encoded by: hsa:5332
name: PLCB4
initial amount: NaN
is: E2QRH8
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species

metaR r0836
is: SBO:0000185
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.16
modifier: MODEL1310110056#
product: MODEL1310110056#

metaM lnlncgcoa x
is: HMDB06368
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
initial concentration: 1.0
is: CHEBI:57363
name: gamma-linolenoyl-CoA(4-)
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false

metaR GASNASE3ly
name: glycosylasparaginase, lysosomal
modifier: MODEL1310110056#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.26
reactant: MODEL1310110056#
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110056#
is described by: ECO:0000000
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD

metaM pan4p c
constant: false
is: SBO:0000247
name: Pantetheine 4'-phosphate
type: Species
initial concentration: 1.0
is: C01134
initial amount: NaN
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
has only substance units: false
boundary condition: false
is: CHEBI:47942
is: HMDB01416

metaR DALAt2r
type: Reaction
is: SBO:0000185
reversible: true
modifier: MODEL1310110056#
reactant: MODEL1310110056#
product: MODEL1310110056#
name: D-alanine transport via proton symport
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110056#_86341ac2_e2b3_4bb4_bc52_95ed2afaec2b
is encoded by: hsa:767
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: CA8
is: P35219
boundary condition: true
initial amount: NaN

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_b9a8e8ce_ae6d_4e4f_8ba3_db461ebf03b6
has only substance units: false
boundary condition: true
initial concentration: NaN
name: BCKDHA
constant: false
is: B4DP47
type: Species
is: SBO:0000252
is encoded by: hsa:593
initial amount: NaN

metaM sbcoa c
boundary condition: false
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
initial concentration: 1.0
initial amount: NaN
name: suberylcoa
is: C02838
constant: false
type: Species
has only substance units: false
is: HMDB00791
is: SBO:0000247

metaR r1966
reversible: false
reactant: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000000
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110056#
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110056#_d8929a27_be1f_46f5_a46d_28883a4f6308
is: P21912
is encoded by: hsa:6390
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
name: SDHB
initial concentration: NaN

metaR FAOXC101C102x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)x
type: Reaction

metaM arachcoa c
is: HMDB04258
constant: false
is: SBO:0000247
has only substance units: false
type: Species
name: arachidyl coenzyme A
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
initial amount: NaN
boundary condition: false
is: CHEBI:15527
initial concentration: 1.0

metaM 4mop c
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
is: CHEBI:17865
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
name: 4-methyl-2-oxopentanoate
initial amount: NaN
is: HMDB00695

http://identifiers.org/biomodels.db/MODEL1310110056#_552fab98_85a2_44fb_ad75_3b4f92f0a2ce
is: SBO:0000252
constant: false
initial amount: NaN
name: ZADH2
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:284273
boundary condition: true
is: Q8N4Q0

metaR CYTK5n
is: SBO:0000176
fast: false
reversible: true
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110056#
is described by: ECO:0000269
reactant: MODEL1310110056#
product: MODEL1310110056#
name: cytidylate kinase (CMP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
type: Reaction

metaR EICOSTETCPT1
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110056#
reactant: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000269
name: carnitine O-palmitoyltransferase

metaM hexdicoa r
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00672
is: C08260
type: Species
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
initial amount: NaN
boundary condition: false
name: hexadecanedioylcoa
initial concentration: 1.0

metaR EX decdicrn
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_3b00d8b0_58b0_44e7_9783_046c86a5e087
has only substance units: false
is: SBO:0000252
name: ALDH1B1
boundary condition: true
is encoded by: hsa:219
initial amount: NaN
constant: false
initial concentration: NaN
is: P30837
type: Species

metaM CE2433 m
is: SBO:0000247
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
boundary condition: false
is: CHEBI:57795
constant: false

metaM 3hibutcoa m
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:28259
constant: false
is: HMDB01052
name: (S)-3-Hydroxyisobutyryl-CoA
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
initial amount: NaN

metaM coa c
initial amount: NaN
boundary condition: false
is: C00010
is: HMDB01423
constant: false
initial concentration: 1.0
is: CHEBI:3312
is: SBO:0000247
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
type: Species
name: Coenzyme A
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_46c4ac68_b431_4810_a354_18edafe77539
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: NDUFA13
is: SBO:0000252
boundary condition: true
is encoded by: hsa:51079
is: Q9P0J0
has only substance units: false

metaR r2110
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#
fast: false
is described by: ECO:0000000
product: MODEL1310110056#
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_0aa51224_7612_42b4_8a85_f8a5db36afcd
name: SLC22A1
is: O15245
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6580
constant: false
has only substance units: false
boundary condition: true

metaM nrpphr c
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: HMDB00216
is: SBO:0000247
type: Species
name: Norepinephrine
boundary condition: false
is: CHEBI:33569
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_5d2b8178_0cac_4c21_9071_5b84dcf59c8e
has only substance units: false
is: F5H123
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9856
initial amount: NaN
type: Species
name: DYLX2
is: SBO:0000252
constant: false

metaM h2o g
has only substance units: false
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
initial amount: NaN
is: HMDB02111
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
name: water

metaR TRIODTHYt2
modifier: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000269
type: Reaction
reversible: true
kinetic law: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
fast: false
is: SBO:0000185
name: T3 transport via facilitated diffusion

metaR RE3245C
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
reversible: true
kinetic law: MODEL1310110056#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110056#
name: RE3245
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_c5144a9c_cfa1_4257_bb96_22e0f240a0ed
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: _AA021081_1_r
constant: false
is encoded by: hsa:AA021081
has only substance units: false
type: Species
initial concentration: NaN

metaM dag hs c
initial amount: NaN
constant: false
is: CHEBI:18035
initial concentration: 1.0
name: diglyceride
is: SBO:0000247
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
has only substance units: false
type: Species

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_d8709989_3830_4124_a94a_7135b760a798
boundary condition: true
type: Species
is encoded by: hsa:2181
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: ACSL3
is: O95573
constant: false
initial amount: NaN

metaR PROD2
is version of: http://identifiers.org/ec-code/1.5.99.8
product: MODEL1310110056#
modifier: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR
type: Reaction
fast: false
name: Proline dehydrogenase
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110056#
is described by: ECO:0000254

metaM hx2coa x
name: trans-Hex-2-enoyl-CoA
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/11966188
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
initial amount: NaN
is: HMDB06870
constant: false
is: C05998
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_5633e398_47c2_4c3e_8dce_780f8d2d1084
constant: false
is: SBO:0000252
has only substance units: false
is: Q308M7
is encoded by: hsa:5169
initial amount: NaN
name: ENPP3
boundary condition: true
type: Species
initial concentration: NaN

metaM udpacgal g
type: Species
name: UDP-N-acetyl-D-galactosamine(2-)
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: HMDB00304
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57847

metaR DNDPt28m
fast: false
modifier: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
name: dCDP transport via dGDP antiport
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110056#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_237f47fc_0613_4847_97eb_685d706ded22
is encoded by: hsa:501
is: SBO:0000252
initial concentration: NaN
name: ALDH7A1
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
constant: false
is: E7EPT3

metaR RE2799C
name: RE2799
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110056#

metaR GTHRDt
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
product: MODEL1310110056#
name: Glutathione transport into mitochondria

metaM btamp m
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
is: HMDB04220
type: Species
initial amount: NaN
name: Biotinyl-5'-AMP
boundary condition: false
is: SBO:0000247
is: CHEBI:3110
initial concentration: 1.0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_524018a6_d7c8_4775_87cc_44c6b6b20dd9
is encoded by: hsa:5150
boundary condition: true
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: PDE7A
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_cd11516b_6ac7_454b_b296_e2362dd3e1c8
is: P16219
has only substance units: false
name: ACADS
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:35
constant: false
type: Species

metaM h2o e
is: CHEBI:15377
name: H2O
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB02111
is: C00001
constant: false
has only substance units: false
boundary condition: false

metaR r2112
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000000
reactant: MODEL1310110056#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR URATEt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false
name: urate export from cytosol
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000185
reactant: MODEL1310110056#

metaR DOLPH Uer
name: Dolichol-phosphate phosphohydrolase, human (uterus)
type: Reaction
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
reactant: MODEL1310110056#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_05051717_ec70_403e_96b3_8092a4dc093d
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: CYP1B1
has only substance units: false
type: Species
is: SBO:0000252
is: Q16678
constant: false
is encoded by: hsa:1545

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaM h2o c
notes: FORMULA: H2O CHARGE: 0
constant: false
name: H2O
is: CHEBI:3303
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB02111
is: SBO:0000247
type: Species
is: C00001
has only substance units: false

metaM odecoa c
has only substance units: false
type: Species
is: HMDB01322
is: CHEBI:3793
boundary condition: false
initial amount: NaN
name: Octadecenoyl-CoA (n-C18:1CoA)
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM ksi deg29 l
is: SBO:0000247
is: CHEBI:12936
boundary condition: false
is: HMDB00143
constant: false
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
name: keratan sulfate I, degradation product 29
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_80b410f9_1bf8_4f6d_929e_712064672a29
type: Species
is encoded by: hsa:124
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P07327
name: ADH1A
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_68e43ee2_8813_41e4_b68e_f49e70c5cded
is: Q6IBC0
is encoded by: hsa:3155
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: HMGCL
has only substance units: false
type: Species

metaM melatn c
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
constant: false
name: melatonin
is: HMDB01389
notes: FORMULA: C13H16N2O2 CHARGE: 0 INCHI: InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C01598
is: CHEBI:16796
initial concentration: 1.0

metaR DNDPt34m
modifier: MODEL1310110056#
product: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110056#
type: Reaction
is: SBO:0000185
fast: false
name: dGDP transport via dTDP antiport
kinetic law: MODEL1310110056#
is described by: ECO:0000269

metaR r2111
product: MODEL1310110056#
reactant: MODEL1310110056#
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110056#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110056#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_2ea7e6c5_c4d2_4e35_9b96_747c222d9a37
initial concentration: NaN
type: Species
is: O95436
initial amount: NaN
is: SBO:0000252
name: SLC34A2
constant: false
is encoded by: hsa:10568
boundary condition: true
has only substance units: false

metaR S23Tg
modifier: MODEL1310110056#
type: Reaction
is: SBO:0000176
name: beta-galactoside alpha-2,3-sialyltransferase (T antigen)
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.4
product: MODEL1310110056#
is described by: ECO:0000269
kinetic law: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (6482.1) or (6482.2) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:8027041 NOTES:NCD
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_1ef67935_80df_4c82_a941_b7d5f5719433
constant: false
name: PIGQ
type: Species
boundary condition: true
is encoded by: hsa:9091
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: B2RAU6
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_016beaf5_6f06_4ae5_896c_51ae7e38a459
constant: false
is: SBO:0000252
type: Species
is: Q4J699
has only substance units: false
name: ATP2B2
boundary condition: true
is encoded by: hsa:491
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_3fafb150_9a42_4ede_b226_8369d36fd6c1
name: UGP2
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:7360
boundary condition: true
is: Q16851
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_627345d3_145c_4193_958e_4fc67ef0542b
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AA788780
name: _AA788780_1_c
has only substance units: false
initial amount: NaN
boundary condition: true

metaR r0812
fast: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110056#
product: MODEL1310110056#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
is version of: http://identifiers.org/ec-code/2.3.1.41
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_8f1ae684_294a_41a1_9edd_4357b09d9489
name: SRD5A1
is encoded by: hsa:6715
is: P18405
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false

metaR CSAPASEly
is: SBO:0000176
fast: false
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)
type: Reaction
is described by: ECO:0000000
reversible: false

metaR S6T13g
fast: false
product: MODEL1310110056#
is: SBO:0000176
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110056#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_dcc10105_541c_40ec_8989_fb86ad1bcfed
initial amount: NaN
is: O94903
has only substance units: false
is encoded by: hsa:11212
initial concentration: NaN
boundary condition: true
name: PROSC
constant: false
type: Species
is: SBO:0000252

metaM glgchlo e
is: SBO:0000247
name: beta glucan-glycocholate complex
constant: false
type: Species
is: HMDB00725
boundary condition: false
has only substance units: false
notes: FORMULA: C1200026H2200043NO1100006 CHARGE: 0
initial concentration: 1.0
initial amount: NaN

metaM retinal c
has only substance units: false
constant: false
name: retinal
is: CHEBI:15035
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
is: HMDB01358
boundary condition: false
type: Species

metaM HC01603 c
has only substance units: false
constant: false
name: 10-Formyltetrahydrofolate
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: SBO:0000247
type: Species
is: C00234
boundary condition: false
is: CHEBI:57454
initial amount: NaN

metaM pcrn c
is: HMDB00824
type: Species
is: http://identifiers.org/pubchem.compound/107738
has only substance units: false
constant: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
boundary condition: false
name: propionyl-carnitine
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM coa e
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
name: Coenzyme A
is: C00010
has only substance units: false
constant: false
boundary condition: false
is: HMDB01423
type: Species
is: CHEBI:57287
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM itacon m
is: CHEBI:17240
boundary condition: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
type: Species
name: itaconate(2-)
initial concentration: 1.0
constant: false
is: HMDB02092
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_33b6f3dd_21e6_44a2_b0b3_01848a26a0dd
is: Q16854
is encoded by: hsa:1716
name: DGUOK
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_73872050_0c23_464d_87e3_535a44af3fde
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000297
is encoded by: hsa:124
boundary condition: true
initial concentration: NaN
name: ADH1A:ADH1B
has part: P07327

metaM nrpphr e
is: HMDB00216
is: SBO:0000247
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
name: Norepinephrine
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:33569
initial amount: NaN
type: Species

metaM udpacgal l
boundary condition: false
is: SBO:0000247
name: UDP-N-acetyl-D-galactosamine(2-)
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00304
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: CHEBI:57847
type: Species
constant: false

metaR FAOXC183806m
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110056#
product: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000269
reactant: MODEL1310110056#
name: Beta oxidation of fatty acid
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR NRPPHRSFt
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
fast: false
is: SBO:0000185
kinetic law: MODEL1310110056#
name: norepinephrine sulfate transport (diffusion)
reversible: false
product: MODEL1310110056#
is described by: ECO:0000000
type: Reaction

metaR r1443
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110056#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110056#
product: MODEL1310110056#
name: EC:1.3.3.6

metaR H2O2tp
product: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
is: SBO:0000185
fast: false
name: hydrogen peroxide peroxisomal transport via diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110056#
reversible: true
reactant: MODEL1310110056#

metaM ksi pre15 g
is: CHEBI:58053
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 15
is: C00130
has only substance units: false
constant: false
type: Species
boundary condition: false
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
is: HMDB00175
is: SBO:0000247

metaR EICOSTETCPT2
is: SBO:0000176
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_f5482c6a_48a4_40e2_9d6b_036467658721
has only substance units: false
initial amount: NaN
name: ND6
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4541
is: Q7GXZ1
type: Species
constant: false

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaM nad r
constant: false
initial amount: NaN
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
initial concentration: 1.0
name: NAD(1-)
is: CHEBI:57540
boundary condition: false
type: Species
is: HMDB00902
is: SBO:0000247
has only substance units: false

metaM C05280 m
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28002
boundary condition: false
type: Species
constant: false
is: HMDB03952
is: SBO:0000247
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
name: cis,cis-3,6-Dodecadienoyl-CoA

metaM ctdecdcoa m
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
is: HMDB00792
is: C08277
name: cis2trans4decadienoylcoa
boundary condition: false
constant: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR r2118
product: MODEL1310110056#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110056#
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110056#

metaR PTDCACRNCPT1
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110056#
reversible: false
modifier: MODEL1310110056#
name: carnitine fatty-acyl transferase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
fast: false

metaR G6PDH1rer
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.47
reversible: true
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#

metaR TREHe
reactant: MODEL1310110056#
fast: false
reversible: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000269
modifier: MODEL1310110056#
type: Reaction
is: SBO:0000176
name: alpha,alpha-trehalase
is version of: http://identifiers.org/ec-code/3.2.1.28
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaR GALASE6ly
modifier: MODEL1310110056#
name: beta-galactosidase, lysosomal
reactant: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110056#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18

http://identifiers.org/biomodels.db/MODEL1310110056#_ac8c3c42_e0f0_468e_bc66_2eb3617946cc
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: Q92521
is: SBO:0000252
has only substance units: false
boundary condition: true
name: PIGB
is encoded by: hsa:9488

metaR RIBt
reactant: MODEL1310110056#
reversible: true
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110056#
product: MODEL1310110056#
name: ribose transport via diffusion
is described by: ECO:0000000

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

metaM h2o n
type: Species
constant: false
name: water
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
is: CHEBI:15377
initial amount: NaN

metaR PTDCACRNCPT2
modifier: MODEL1310110056#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
is: SBO:0000176
reactant: MODEL1310110056#
name: pentadecanoate transport into the mitochondria
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#

metaM octa c
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00482
notes: FORMULA: C8H15O2 CHARGE: -1
is: CHEBI:25646
name: octanoate (n-C8:0)
is: SBO:0000247
boundary condition: false
constant: false
is: C06423

metaM paps g
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: CHEBI:58339
is: HMDB01134
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
has only substance units: false

metaR r0817
is version of: http://identifiers.org/ec-code/2.3.1.41
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110056#
fast: false
product: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_6bcf88e4_bb8b_42fe_b648_0988e11a341c
initial concentration: NaN
is: Q9H6Y6
boundary condition: true
type: Species
constant: false
name: MYO5B
initial amount: NaN
is encoded by: hsa:4645
has only substance units: false
is: SBO:0000252

metaR r2117
type: Reaction
reactant: MODEL1310110056#
product: MODEL1310110056#
modifier: MODEL1310110056#
reversible: true
kinetic law: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

metaR UDPtl
reversible: true
name: udp intracellular transport
kinetic law: MODEL1310110056#
product: MODEL1310110056#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
is: SBO:0000185
type: Reaction

metaR GGH 7DHFe
kinetic law: MODEL1310110056#
name: Gamma-glutamyl hydrolase (7DHF), extracellular
reversible: false
modifier: MODEL1310110056#
product: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176

metaM 3deccrn c
initial concentration: 1.0
constant: false
has only substance units: false
name: 3-hydroxydecanoylcarnitine
initial amount: NaN
is: HMDB13325
notes: FORMULA: C17H33NO5 CHARGE: 0
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_99039e80_ff11_448f_b38c_129c783a0c7c
constant: false
is: SBO:0000252
is encoded by: hsa:3423
has only substance units: false
type: Species
is: P22304
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: IDS

metaR r1552
is: SBO:0000185
kinetic law: MODEL1310110056#
is described by: ECO:0000000
product: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true

metaM h2o m
name: H2O
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: HMDB02111
is: CHEBI:15377
constant: false
has only substance units: false
is: SBO:0000247
is: C00001

metaM dag hs n
is: SBO:0000247
name: diglyceride
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
has only substance units: false
initial amount: NaN
is: CHEBI:18035

metaM hs deg13 l
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
name: heparan sulfate, degradation product 13
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
boundary condition: false
is: HMDB06210
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_b16c684c_0322_48fb_8508_b9333e29c3d7
is: O43272
is encoded by: hsa:5625
is: SBO:0000252
type: Species
has only substance units: false
constant: false
name: PRODH
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaR PIt7
modifier: MODEL1310110056#
name: phosphate transport in/out via three Na+ symporter
is: SBO:0000185
product: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
kinetic law: MODEL1310110056#
type: Reaction
fast: false
is described by: ECO:0000269
reactant: MODEL1310110056#

metaR TRPt4
reversible: false
reactant: MODEL1310110056#
product: MODEL1310110056#
fast: false
is: SBO:0000185
name: L-tryptophan transport in via sodium symport
kinetic law: MODEL1310110056#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
type: Reaction
modifier: MODEL1310110056#

metaM HC01223 m
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57340
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
constant: false

metaR C80CPT1
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of octanoylcarnitine
type: Reaction

metaM betald c
is: CHEBI:15710
type: Species
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: betaine aldehyde
is: HMDB01252
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
initial concentration: 1.0

metaM core6 g
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16478
notes: FORMULA: C16H27N2O10X CHARGE: 0
constant: false
name: Core 6
boundary condition: false

metaR r1551
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#

metaR CSNAT3x
fast: false
is described by: ECO:0000269
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000176
reactant: MODEL1310110056#
type: Reaction
name: carnitine O-aceyltransferase, peroxisomal
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:7654220,PMID:7829107 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.7
reversible: true

metaM HC01104 e
type: Species
constant: false
initial amount: NaN
name: 4-nitrophenyl phosphate(2-)
is: CHEBI:61146
boundary condition: false
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_0435f93e_7aa2_457b_a7ce_f492783729dd
name: _AV717590_1_m
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AV717590
boundary condition: true
is: SBO:0000252

metaR r1791
type: Reaction
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110056#
reversible: false
reactant: MODEL1310110056#
is described by: ECO:0000000
fast: false
product: MODEL1310110056#

metaM h2o l
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
is: SBO:0000247
initial amount: NaN
name: water
initial concentration: 1.0
is: CHEBI:15377
type: Species
boundary condition: false
has only substance units: false
constant: false

metaM octa e
is: HMDB00482
boundary condition: false
is: C06423
initial concentration: 1.0
type: Species
notes: FORMULA: C8H15O2 CHARGE: -1
has only substance units: false
is: SBO:0000247
name: octanoate (n-C8:0)
is: CHEBI:25646
constant: false
initial amount: NaN

metaR NDPK3m
modifier: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reversible: true
is described by: ECO:0000254
is: SBO:0000176

metaR r2119
product: MODEL1310110056#
is: SBO:0000185
reversible: true
modifier: MODEL1310110056#
is described by: ECO:0000000
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110056#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM n2m2nm l
notes: FORMULA: C58H97N5O41 CHARGE: 0
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:30825
name: n2m2nmasn (w/o peptide linkage)
is: HMDB00573
is: SBO:0000247
has only substance units: false

metaR PIt8
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
fast: false
is described by: ECO:0000006
reversible: true
reactant: MODEL1310110056#
type: Reaction
is: SBO:0000185
product: MODEL1310110056#
modifier: MODEL1310110056#
name: phosphate transport in/out via Na+ symporter
kinetic law: MODEL1310110056#

metaM core6 l
is: SBO:0000247
type: Species
is: HMDB00143
constant: false
initial amount: NaN
name: Core 6
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: CHEBI:12936

metaR FAOXC11C9m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C11-->C9)m
type: Reaction

metaM g1m8mpdol U r
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:59093
constant: false
initial amount: NaN
notes: FORMULA: C1785H2940N20O670P20 CHARGE: -20
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
boundary condition: false

metaR r2114
fast: false
reactant: MODEL1310110056#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction
modifier: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_2dac6572_2210_43ff_9c3a_17ac0d0d7fd6
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: _R51273_1_c
boundary condition: true
is encoded by: hsa:R51273
constant: false
type: Species

metaR FAOXC162C162OHm
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:2-->C16:2OH)m
type: Reaction

metaM CE5786 e
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: kinetensin
type: Species
is: CHEBI:27485
initial amount: NaN
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
is: HMDB02710
boundary condition: false
constant: false

metaR RE0830N
type: Reaction
is: SBO:0000176
reactant: MODEL1310110056#
name: RE0830
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/4.2.1.96
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
kinetic law: MODEL1310110056#
reversible: true
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_a05866d2_98bc_4b9c_bc9f_a6a32144877f
boundary condition: true
type: Species
is encoded by: hsa:3030
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: HADHA
is: E9KL44
constant: false
initial concentration: NaN

metaR ADKd
fast: false
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176
name: adenylate kinase (d form)

http://identifiers.org/biomodels.db/MODEL1310110056#_f024421a_b7c0_4741_8ba8_d57e683961c9
type: Species
initial concentration: NaN
is encoded by: hsa:1384
has only substance units: false
constant: false
name: CRAT
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR MMMm
product: MODEL1310110056#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.4.99.2
fast: false
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
modifier: MODEL1310110056#
name: methylmalonyl-CoA mutase
type: Reaction
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#

metaR LNLNCGt
reversible: true
product: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110056#
fast: false

metaR r2113
modifier: MODEL1310110056#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110056#

metaM paps c
has only substance units: false
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: SBO:0000247
boundary condition: false
type: Species
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
constant: false
is: HMDB01134
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58339

metaM h2o r
is: CHEBI:15377
is: C00001
type: Species
name: H2O
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

metaR FAOXC101C102m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

metaR r2416
kinetic law: MODEL1310110056#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
product: MODEL1310110056#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110056#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110056#_f409b170_7478_4d64_a230_db642035757b
name: GCNT4
initial concentration: NaN
is encoded by: hsa:51301
is: SBO:0000252
type: Species
has only substance units: false
constant: false
is: Q9P109
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_c6da5f28_29ad_4e56_af55_f40ebcba10f0
constant: false
boundary condition: true
type: Species
is: O75747
is encoded by: hsa:5288
initial concentration: NaN
name: PIK3C2G
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR ACGALtly
type: Reaction
kinetic law: MODEL1310110056#
is: SBO:0000185
name: N-acetyl-galactosamine lysosomal efflux
reactant: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
product: MODEL1310110056#
fast: false
is described by: ECO:0000000

metaR FAOXC2242046m
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
product: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110056#_5b61e546_f393_43f4_a4d6_49c995130fac
has only substance units: false
is encoded by: hsa:27430
is encoded by: hsa:4144
boundary condition: true
type: Species
has part: P31153
name: MAT2B:MAT2A
is: SBO:0000297
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_30ad3185_9c59_486a_9603_1c48b824a298
is: Q9HCR9
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
name: PDE11A
initial concentration: NaN
is encoded by: hsa:50940
has only substance units: false
constant: false

metaR FAOXC227C226m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

metaM dag hs r
boundary condition: false
constant: false
type: Species
has only substance units: false
is: SBO:0000247
name: diglyceride
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
is: CHEBI:18035

metaR AG13T13g
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110056#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110056#
modifier: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaR EX acmana LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-acetyl-D-mannosamine
type: Reaction

metaR DOLPMT4 Uer
type: Reaction
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110056#
is: SBO:0000185
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110056#
fast: false

metaM nad x
is: C00003
name: Nicotinamide adenine dinucleotide
boundary condition: false
is: CHEBI:57540
initial amount: NaN
initial concentration: 1.0
is: HMDB00902
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/3305
constant: false
is: SBO:0000247

metaM hexdiac c
has only substance units: false
name: hexadecanediocacid
initial amount: NaN
boundary condition: false
is: HMDB00672
notes: FORMULA: C16H28O4 CHARGE: -2
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
is: C08260

metaR GLCter
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
name: glucose transport, endoplasmic reticulum
reactant: MODEL1310110056#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110056#_817db3f5_18c8_473c_9132_523b4515c9f2
is encoded by: hsa:7166
is: SBO:0000252
name: TPH1
has only substance units: false
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is: P17752
initial amount: NaN

metaM 4mop e
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
is: HMDB00695
has only substance units: false
name: 4-methyl-2-oxopentanoate
type: Species
initial amount: NaN
is: CHEBI:17865
initial concentration: 1.0

metaR SMPD4
type: Reaction
name: sphingomyelinase
reversible: false
reactant: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
is described by: ECO:0000000
product: MODEL1310110056#
is: SBO:0000176
kinetic law: MODEL1310110056#

metaR r2419
type: Reaction
reversible: true
kinetic law: MODEL1310110056#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reactant: MODEL1310110056#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
product: MODEL1310110056#

metaR DDCRNe
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydodecanoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_806f0c34_4ee5_403f_a6f0_e616c7fa39b3
constant: false
is encoded by: hsa:AI824319
name: _AI824319_1_r
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM tetdece1coa c
is: HMDB05066
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
constant: false
has only substance units: false
name: tetradecenoylcoa
initial concentration: 1.0
boundary condition: false
type: Species

metaR r2116
kinetic law: MODEL1310110056#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110056#
product: MODEL1310110056#

metaR r2115
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
fast: false
modifier: MODEL1310110056#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110056#_559ac7b1_349a_415c_ba07_fb6d227b6fcc
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:6817
boundary condition: true
name: SULT1A1
initial concentration: NaN
constant: false

metaM 3deccrn e
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
name: 3-hydroxydecanoylcarnitine
is: C02838
is: HMDB00791
notes: FORMULA: C17H33NO5 CHARGE: 0
is: SBO:0000247
constant: false

metaM pail hs n
is: CHEBI:57880
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol(1-)
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_0f61dde4_f888_40d1_8275_42c6e6bd13bf
is encoded by: hsa:23057
name: NMNAT2
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
constant: false
initial amount: NaN

metaR EX 3tdcrn
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-tetradecanoyl carnitine
type: Reaction

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaM coa r
type: Species
is: HMDB01423
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: C00010
is: CHEBI:57287
name: Coenzyme A
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_580d758c_319d_4311_ac00_56f43dfbd910
is encoded by: hsa:9334
is: O43286
has only substance units: false
is: SBO:0000252
constant: false
name: B4GALT5
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN

metaM dcsptn1 c
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
constant: false
is: http://identifiers.org/pubchem.compound/5282848
is: HMDB13123
has only substance units: false
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoic acid
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247

metaR RETI2
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
product: MODEL1310110056#
name: retinol isomerase (9-cis)
type: Reaction
fast: false
reactant: MODEL1310110056#
is described by: ECO:0000000
reversible: true
is: SBO:0000176

metaM dd2coa m
type: Species
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: CHEBI:57330
constant: false
is: SBO:0000247
is: HMDB03712
initial amount: NaN
has only substance units: false
boundary condition: false
name: trans-dodec-2-enoyl-CoA(4-)
initial concentration: 1.0

metaM 3tetd7ecoacrn c
boundary condition: false
is: HMDB02014
initial amount: NaN
has only substance units: false
notes: FORMULA: C21H39NO5 CHARGE: 0
constant: false
initial concentration: 1.0
name: 3-hydroxy tetradecenoyl-7-carnitine
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_3f863662_78bb_4ae1_8242_76847ec5e6c0
is: Q53YB7
is: SBO:0000252
is encoded by: hsa:1329
boundary condition: true
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: COX5B
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_6aef8a4e_5f48_4d33_af08_a8237339297c
has only substance units: false
is: SBO:0000252
boundary condition: true
name: LHPP
constant: false
initial concentration: NaN
is: Q9H008
initial amount: NaN
type: Species
is encoded by: hsa:64077

http://identifiers.org/biomodels.db/MODEL1310110056#_c520ab45_ade8_4298_b088_366b7cda5550
initial concentration: NaN
has part: Q86U05
initial amount: NaN
boundary condition: true
name: SLC7A8:SLC3A2
type: Species
constant: false
is encoded by: hsa:23428
has only substance units: false
is: SBO:0000297

metaR r1557
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110056#

metaM adp x
is: HMDB01341
name: ADP(3-)
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:456216
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008

metaR RETI1
type: Reaction
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
is described by: ECO:0000000
product: MODEL1310110056#
name: retinol isomerase (11-cis)
reversible: true
is: SBO:0000176
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_70096ef5_bf49_46c8_a02c_bb4a63219ef3
initial concentration: NaN
name: HADHB
is: P55084
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:3032

http://identifiers.org/biomodels.db/MODEL1310110056#_6dd45ade_bb26_41c1_800f_0e7c0933166a
is: Q13370
initial amount: NaN
name: PDE3B
has only substance units: false
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:5140
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_3f34b69e_21ec_4de1_875a_7ddb98c0f3a5
has only substance units: false
constant: false
is encoded by: hsa:125206
type: Species
initial concentration: NaN
initial amount: NaN
is: A0PJK1
is: SBO:0000252
name: SLC5A10
boundary condition: true

metaR DM dem2emgacpail prot hs r
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dem2emgacpail prot hs(r)
type: Reaction

metaR RE1516M
is version of: http://identifiers.org/ec-code/1.3.99.13
is: SBO:0000176
type: Reaction
fast: false
name: RE1516
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110056#

metaR FAOXC2242046x
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110056#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110056#
product: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110056#_a0a1152d_608d_405b_888f_c7702c06f4b3
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
constant: false
name: NDUFB6
is: SBO:0000252
is: O95139
is encoded by: hsa:4712

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaM malcoa c
name: Malonyl-CoA
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
initial concentration: 1.0
boundary condition: false
is: HMDB01175
type: Species
has only substance units: false
is: C00083
is: CHEBI:57384
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_8cd0677a_3b70_4d2e_b876_3f784d7bea6d
name: ACP2
is: E9PCI1
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:53

http://identifiers.org/biomodels.db/MODEL1310110056#_6771cf20_2929_4c9c_b55e_9e6b36b9d3d3
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:8818
has only substance units: false
name: DPM2
is: SBO:0000252

metaR FAOXC122C101m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

metaR AG13T12g
reversible: false
modifier: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_8f4b916d_4206_42c6_ab1f_46a3a8bbfb42
has only substance units: false
is: SBO:0000252
is: O43280
initial amount: NaN
is encoded by: hsa:11181
boundary condition: true
type: Species
constant: false
name: TREH
initial concentration: NaN

metaM 2docohexecoa m
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
initial amount: NaN
name: 2,7,10,13,16,19-docosahexenoylcoa
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
type: Species

metaR r1559
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR DPMVDc
modifier: MODEL1310110056#
name: diphosphomevalonate decarboxylase, cytosol
is described by: ECO:0000134
is: SBO:0000176
type: Reaction
product: MODEL1310110056#
reversible: false
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added t product for elemental balancing.
fast: false
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/4.1.1.33

metaR FAOXC183806x
is version of: http://identifiers.org/ec-code/1.3.3.6
name: Beta oxidation of long chain fatty acid
reversible: false
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
reactant: MODEL1310110056#
product: MODEL1310110056#

metaR 25HVITD3t
reversible: false
type: Reaction
is: SBO:0000185
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
name: 25-hydroxyvitamin D3 transport from cytoplasm
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12045394 NOTES:is found in blood --> subsequently has to be transported but how? based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT. Biochemical

metaM ksii core2 l
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57255
type: Species
name: keratan sulfate II (core 2-linked)
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: HMDB01014
constant: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_cbbd3416_220e_4930_a8d0_53fe3e42ca0c
name: SLC6A3
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6531
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is: Q01959

http://identifiers.org/biomodels.db/MODEL1310110056#_b661e0b3_8115_483e_869c_3d0f42246386
is encoded by: hsa:11001
boundary condition: true
name: SLC27A2
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
is: O14975

metaM 4abut e
has only substance units: false
is: C00334
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0
is: HMDB00112
name: 4-Aminobutanoate
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:3628

metaR 25HVITD3tm
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:is found in blood --> subsequently has to be transported but how? based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
product: MODEL1310110056#
kinetic law: MODEL1310110056#
name: 25-hydroxyvitamin D3 transport from mitochondria
reversible: false
type: Reaction
reactant: MODEL1310110056#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110056#_f0c6d5b1_a0c9_464a_a4e8_d45753070e78
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:124583
has only substance units: false
is: SBO:0000252
is: Q8WVQ1
boundary condition: true
type: Species
name: CANT1

http://identifiers.org/biomodels.db/MODEL1310110056#_9fd92da4_7bbb_4eec_9ec3_404c5c8f655a
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaM malcoa e
type: Species
name: malonyl-CoA(4-)
constant: false
is: HMDB01175
is: CHEBI:57384
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
has only substance units: false
initial amount: NaN
boundary condition: false

metaR RE3244R
name: RE3244
product: MODEL1310110056#
reversible: true
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000000

metaM hmgcoa c
initial concentration: 1.0
initial amount: NaN
name: Hydroxymethylglutaryl-CoA
is: HMDB01375
boundary condition: false
is: SBO:0000247
is: CHEBI:15467
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
type: Species
has only substance units: false
constant: false

metaR G14T18g
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110056#
is described by: ECO:0000000
modifier: MODEL1310110056#
reactant: MODEL1310110056#
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110056#

metaR TDCHOLAte
is: SBO:0000185
reactant: MODEL1310110056#
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000000
type: Reaction
fast: false

metaM dcdp n
has only substance units: false
is: CHEBI:58593
boundary condition: false
initial concentration: 1.0
is: HMDB01245
initial amount: NaN
name: dCDP(3-)
is: SBO:0000247
constant: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_3cd8ba9e_24e2_4af0_9395_2698d337e8fb
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:218
is: P30838
name: ALDH3A1

metaR 3HKYNAKGAT
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
type: Reaction
reversible: false
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.7
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.6.1.64
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase

metaM pail4p hs c
boundary condition: false
constant: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
initial amount: NaN
is: CHEBI:58178
is: SBO:0000247
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
type: Species
initial concentration: 1.0

metaM dcdp m
is: CHEBI:58593
is: HMDB01245
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
has only substance units: false
type: Species
name: dCDP(3-)
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0

metaM nad m
is: CHEBI:57540
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: Nicotinamide adenine dinucleotide
type: Species
constant: false
is: C00003
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3305
boundary condition: false
is: HMDB00902

metaM odecoa r
type: Species
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
name: oleoyl-CoA(4-)
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB01322
initial concentration: 1.0
is: CHEBI:57387
boundary condition: false

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaR r1553
is: SBO:0000185
reactant: MODEL1310110056#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110056#
kinetic law: MODEL1310110056#

metaM chito2pdol U c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
is: CHEBI:12427
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C1185H1940N20O170P20 CHARGE: -20

metaR AG13T3g
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110056#
fast: false
product: MODEL1310110056#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
reversible: false
reactant: MODEL1310110056#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110056#_a963cdf7_ccbb_47f4_a243_d3eeaaee482a
name: ND2
constant: false
initial concentration: NaN
is: Q7GXY9
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:4536

metaM 4abut c
type: Species
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0
name: 4-Aminobutanoate
is: C00334
is: HMDB00112
is: SBO:0000247
constant: false
is: CHEBI:3628
boundary condition: false
initial amount: NaN
has only substance units: false

metaR ACALDt
reversible: true
fast: false
kinetic law: MODEL1310110056#
is described by: ECO:0000000
name: acetaldehyde reversible transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000185
product: MODEL1310110056#
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_9056ca31_7f6f_41c4_bb9f_d98ede8b1784
boundary condition: true
constant: false
is encoded by: hsa:AI480132
initial concentration: NaN
name: _AI480132_1_c
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species

metaM nad n
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
constant: false
name: NAD(1-)
is: CHEBI:57540
is: HMDB00902
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
initial concentration: 1.0
initial amount: NaN

metaM coa x
has only substance units: false
initial amount: NaN
is: CHEBI:57287
boundary condition: false
initial concentration: 1.0
is: HMDB01423
is: SBO:0000247
type: Species
name: Coenzyme A
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: C00010
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_c4759909_164e_4db2_90c0_17e972d47a33
is encoded by: hsa:U37519
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: _U37519_1_m
constant: false

metaR r0179
product: MODEL1310110056#
type: Reaction
reversible: true
is: SBO:0000176
fast: false
modifier: MODEL1310110056#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.27
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16

metaR r1554
is described by: ECO:0000000
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110056#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110056#
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110056#_acc1869d_ebc7_4b4a_b795_a6280249446d
initial amount: NaN
is: SBO:0000252
name: HK3
type: Species
is encoded by: hsa:3101
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P52790

metaM nrvnc e
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
is: HMDB02368
type: Species
name: nervonate
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:32392

metaR C81CPT1
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of ocetenoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_277e1fb5_c7c9_427e_abd6_ee7f23f143ba
is encoded by: hsa:6576
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial concentration: NaN
name: SLC25A1
initial amount: NaN
is: D9HTE9

metaM h2o x
name: H2O
is: CHEBI:15377
has only substance units: false
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
is: C00001
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_e5ea687f_f10d_4313_bb84_8b2e086f3774
has part: O95497
name: VNN3:VNN2:VNN1
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:55350
initial amount: NaN
is encoded by: hsa:8876
is: SBO:0000297
is encoded by: hsa:8875
constant: false
has part: A8K7W0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_eb56470e_8d1a_47f7_a7f6_87ee397e576b
initial concentration: NaN
boundary condition: true
has only substance units: false
name: _H17063_1_m
constant: false
is encoded by: hsa:H17063
is: SBO:0000252
initial amount: NaN
type: Species

metaR PHEACGLNt
name: PHEACGLN extracellular transport via diffusion
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110056#
type: Reaction
is: SBO:0000185
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_0dba14f0_b3dd_41f9_af98_6309298d94b1
initial amount: NaN
type: Species
name: PDE7B
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:27115
boundary condition: true
is: Q9NP56
initial concentration: NaN

metaM leuktrA4 r
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB01337
is: SBO:0000247
initial amount: NaN
type: Species
name: leukotriene A4(1-)
is: CHEBI:57463
constant: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR r0178
fast: false
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
is version of: http://identifiers.org/ec-code/2.5.1.21
kinetic law: MODEL1310110056#
type: Reaction
reversible: true
is: SBO:0000176
modifier: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000
product: MODEL1310110056#

metaR r1556
reversible: true
reactant: MODEL1310110056#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaM hdcea c
is: CHEBI:32372
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
initial concentration: 1.0
initial amount: NaN
type: Species
name: Hexadecenoate (n-C16:1)
constant: false
boundary condition: false
has only substance units: false
is: HMDB03229
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_e6ada1ae_bd97_42bb_ac7c_cd84fdc803f2
initial concentration: NaN
has only substance units: false
is: Q9H999
type: Species
is encoded by: hsa:79646
constant: false
is: SBO:0000252
name: PANK3
initial amount: NaN
boundary condition: true

metaR CORE4GTg
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
reactant: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.102
reversible: false
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#

metaM cs a deg2 l
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:15748
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C37H55NO38S2 CHARGE: -4
is: HMDB00127

metaM arachcoa m
has only substance units: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: HMDB04258
type: Species
initial concentration: 1.0
name: arachidyl coenzyme A
is: CHEBI:15527
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false

metaR DGK1
reversible: true
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.8
is described by: ECO:0000269
fast: false
is: SBO:0000176
kinetic law: MODEL1310110056#
name: deoxyguanylate kinase (dGMP:ATP)
type: Reaction
modifier: MODEL1310110056#
reactant: MODEL1310110056#

metaR FAOXC226205x
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.35
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
product: MODEL1310110056#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM nrvnc c
is: CHEBI:32392
name: nervonate
type: Species
is: HMDB02368
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-

metaR r1444
reactant: MODEL1310110056#
name: EC:1.3.3.6
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
is described by: ECO:0000000
reversible: false
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110056#
kinetic law: MODEL1310110056#

metaR Ser Thrtg
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
fast: false
is described by: ECO:0000269
is: SBO:0000185
reversible: true
name: Ser/Thr transport (from golgi to lysosome)
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_c9673700_e2dc_460a_8570_2251159abcda
has only substance units: false
is: C9JFZ1
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: SYNJ1
constant: false
is encoded by: hsa:8867

metaR SUCCt2m
is: SBO:0000185
product: MODEL1310110056#
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: true
is described by: ECO:0000269
fast: false
reactant: MODEL1310110056#
type: Reaction
name: succinate transport, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110056#_d8f738d7_0551_43ef_a155_178d427a4861
initial amount: NaN
type: Species
is encoded by: hsa:AGPAT7
name: _AGPAT7_1_c
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_c8d59920_497a_4ff0_8a06_99fe09691b36
initial concentration: NaN
has only substance units: false
is encoded by: hsa:54995
type: Species
name: OXSM
initial amount: NaN
is: Q9NWU1
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_1beab56d_9d2f_4a68_8737_18fd003f4653
boundary condition: true
constant: false
name: CHAT
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is: Q6LEN6
initial concentration: NaN
is encoded by: hsa:1103

http://identifiers.org/biomodels.db/MODEL1310110056#_0d4ce7ee_c681_4770_8b87_0e9319bb4987
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q85KV6
constant: false
is encoded by: hsa:4535
name: ND1
has only substance units: false
boundary condition: true
type: Species

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaM odecoa m
is: CHEBI:57387
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
type: Species
name: Octadecenoyl-CoA (n-C18:1CoA)
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB01322
constant: false

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

metaM CE5117 m
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:57923
initial amount: NaN
constant: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA

metaM glyphe e
is: http://identifiers.org/pubchem.compound/97415
notes: FORMULA: C11H14N2O3 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
name: Glycylphenylalanine
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_3c2691cb_2ea4_4ecb_929c_e74856dd45ef
is: P48735
name: IDH2
is encoded by: hsa:3418
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_9fb7e1a4_ced2_4a17_b67b_e82af609ea1a
initial amount: NaN
name: ACOT6
initial concentration: NaN
is: Q3I5F7
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:641372
type: Species
boundary condition: true

metaM ptdcacrn c
boundary condition: false
constant: false
is: SBO:0000247
type: Species
is: CHEBI:18303
name: pendtadenoyl carnitine
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
has only substance units: false

metaM c51crn c
type: Species
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
name: tiglyl carnitine
is: HMDB02366
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C12H21NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110056#_b25c7e20_1fe5_4bfb_817a_f0339887b338
is: SBO:0000252
initial amount: NaN
name: AADAT
boundary condition: true
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:51166
is: Q4W5N8

http://identifiers.org/biomodels.db/MODEL1310110056#_71b2f3f4_8657_4877_ab5b_d0a346823d48
name: MBOAT2
is encoded by: hsa:129642
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
is: Q6ZWT7
has only substance units: false
initial concentration: NaN

metaM pail4p hs n
initial amount: NaN
is: CHEBI:58178
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species

metaR r1445
product: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
name: EC:1.3.3.6
reversible: false

metaM g3m8masn r
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C88H147N2O70X CHARGE: 0
is: C05873
type: Species
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

metaR ACNAM9PL
is version of: http://identifiers.org/ec-code/2.5.1.56
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
is described by: ECO:0000269
fast: false
reversible: false
product: MODEL1310110056#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110056#

metaR FAOXC226205m
modifier: MODEL1310110056#
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
type: Reaction
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
product: MODEL1310110056#
is described by: ECO:0000000
reversible: false

metaR PI3P3Pn
fast: false
kinetic law: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
reversible: false
product: MODEL1310110056#
name: phosphatidylinositol-3-phosphate 3-phosphatase, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:EC 3.1.3.- NCD
is described by: ECO:0000000
is: SBO:0000176

metaR EX asp D LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Aspartate exchange
type: Reaction

metaM nad c
is: C00003
is: http://identifiers.org/pubchem.compound/3305
initial concentration: 1.0
initial amount: NaN
is: HMDB00902
is: CHEBI:57540
type: Species
is: SBO:0000247
constant: false
name: Nicotinamide adenine dinucleotide
boundary condition: false
has only substance units: false

metaM adp n
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial amount: NaN
is: HMDB01341
is: CHEBI:456216
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
name: ADP(3-)
constant: false

metaR FAOXC18280m
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:2, transe -> c8:0 - 5 rounds of beta ox, lose 2 degrees of unsat - only 3 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
is described by: ECO:0000000
fast: false
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
modifier: MODEL1310110056#
name: Beta oxidation of fatty acid

metaR G3PD1
is: SBO:0000176
name: glycerol-3-phosphate dehydrogenase (NAD)
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.1.1.8
type: Reaction
reactant: MODEL1310110056#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
modifier: MODEL1310110056#
reversible: true
product: MODEL1310110056#
fast: false

metaM dd2coa c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB03712
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
constant: false
has only substance units: false
name: trans-Dodec-2-enoyl-CoA

metaR FAOXC121C101m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:1-->C10:1)m
type: Reaction

metaR r0173
fast: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (3704.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:12042361,PMID:17045662,PMID:7449128,PMID:9927705 NOTES:
product: MODEL1310110056#
modifier: MODEL1310110056#
type: Reaction
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.19
is described by: ECO:0000000
name: (S)-Lactate:NAD+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.1.1.27
reactant: MODEL1310110056#

metaR CSPG Btly
product: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000000
reactant: MODEL1310110056#
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: chondroitin sulfate B transport, extracellular to lysosome
reversible: false

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaM glyphe c
is: http://identifiers.org/pubchem.compound/97415
name: Glycylphenylalanine
boundary condition: false
notes: FORMULA: C11H14N2O3 CHARGE: 0
has only substance units: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM ksi pre36 g
initial concentration: 1.0
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
is: CHEBI:28067
constant: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 36
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_24624bd6_293f_4dfa_b236_8a9bfc8a09a8
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
name: _AV713053_1_m
is encoded by: hsa:AV713053
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_f0cc7b2d_b843_4603_8f9f_077714811f98
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000297
name: VNN3:VNN2:VNN1
is encoded by: hsa:55350
initial amount: NaN
boundary condition: true

metaR ACACT1rm
kinetic law: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.9
is version of: http://identifiers.org/ec-code/2.3.1.16
name: acetyl-CoA C-acetyltransferase, mitochondrial
product: MODEL1310110056#
fast: false
type: Reaction
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
reactant: MODEL1310110056#

metaR EX tettet6 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosatetraenoic acid n-6 exchange
type: Reaction

metaM c51crn e
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB02366
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: tiglyl carnitine
notes: FORMULA: C12H21NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110056#_15c4be11_e73a_4925_80da_a1d210ba6268
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:BG035985
constant: false
name: _BG035985_1_c
type: Species

metaM cl c
notes: FORMULA: Cl CHARGE: -1
name: Chloride
constant: false
type: Species
is: HMDB00492
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: C00115
is: CHEBI:3966
initial concentration: 1.0
has only substance units: false

metaM CE4791 x
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
name: 3(S)-hydroxy-dihomo-gama-linolenoyl-CoA
constant: false
notes: FORMULA: C41H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C41H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29(49)24-32(51)70-23-22-43-31(50)20-21-44-39(54)36(53)41(2,3)26-63-69(60,61)66-68(58,59)62-25-30-35(65-67(55,56)57)34(52)40(64-30)48-28-47-33-37(42)45-27-46-38(33)48/h8-9,11-12,14-15,27-30,34-36,40,49,52-53H,4-7,10,13,16-26H2,1-3H3,(H,43,50)(H,44,54)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/b9-8-,12-11-,15-14-/t29-,30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4791
initial concentration: 1.0
is: CHEBI:57923
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_22659ff3_bc1a_4cf0_b4cb_daaa2785e411
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
name: _AA526438_1_m
is: SBO:0000252
is encoded by: hsa:AA526438
constant: false
initial concentration: NaN

metaR HISCAT1
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaR T4HCINNMFM
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
product: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: false
is described by: ECO:0000000
fast: false
name: 4-hydroxycinnamate formation

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

metaR FACOAL240
kinetic law: MODEL1310110056#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
fast: false
modifier: MODEL1310110056#
product: MODEL1310110056#
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
type: Reaction
reactant: MODEL1310110056#

metaM ipdp x
name: isopentenyl diphosphate(3-)
is: HMDB01347
initial concentration: 1.0
is: CHEBI:128769
constant: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species

metaM pcrn m
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
name: propionyl-carnitine
initial concentration: 1.0
is: HMDB00824
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/107738

metaM pro L e
name: L-proline
has only substance units: false
is: CHEBI:17203
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00162
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145

metaR Coqe
product: MODEL1310110056#
name: Transport of q10
is described by: ECO:0000134
kinetic law: MODEL1310110056#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_0b27c499_3ca8_43b6_8355_8d4fea4482ae
initial concentration: NaN
name: LOXL2
constant: false
has only substance units: false
is encoded by: hsa:4017
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is: Q9Y4K0

http://identifiers.org/biomodels.db/MODEL1310110056#_0c18aaee_67c6_43ed_a8f9_3cf0f7f96f49
is encoded by: hsa:LOC728997
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
name: _LOC728997_1_c
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_dac8ff1e_5d5b_412b_b5ec_4374189832ae
constant: false
is encoded by: hsa:34
name: ACADM
is: P11310
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252

metaM coa n
constant: false
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB01423
has only substance units: false
name: coenzyme A(4-)
is: CHEBI:57287

metaR BCRNe
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy butyryl carnitine into extra cellular space
type: Reaction

metaR LINKDEG3ly
is: SBO:0000176
name: degradation of proteoglycan linkage region, lysosomal
product: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110056#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_34c35e66_a416_4b4b_8a9a_82d49ae5c817
constant: false
initial amount: NaN
name: AK4
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:205
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_5bad134c_b670_48dc_8be3_c7d88d1b3043
is: P32019
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:3633
name: INPP5B

http://identifiers.org/biomodels.db/MODEL1310110056#_8c70732b_e4f7_4354_8aed_62758b3a5e1b
is encoded by: hsa:X63359
type: Species
constant: false
name: _X63359_1_c
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN

metaM mi1p D n
boundary condition: false
is: SBO:0000247
constant: false
name: 1D-myo-inositol 1-phosphate(2-)
has only substance units: false
is: CHEBI:58433
initial concentration: 1.0
initial amount: NaN
is: HMDB02985
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
type: Species

metaM hx2coa m
boundary condition: false
is: C05998
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/11966188
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB06870
name: trans-Hex-2-enoyl-CoA
type: Species

metaM dcdp c
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: CHEBI:58593
type: Species
initial concentration: 1.0
name: dCDP
boundary condition: false
is: C00705
is: HMDB01245
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false

metaM hexdiac r
has only substance units: false
initial amount: NaN
name: hexadecanediocacid
is: HMDB00672
notes: FORMULA: C16H28O4 CHARGE: -2
boundary condition: false
type: Species
initial concentration: 1.0
is: C08260
constant: false
is: SBO:0000247

metaM adp m
initial concentration: 1.0
name: ADP
constant: false
is: C00008
initial amount: NaN
is: CHEBI:456216
boundary condition: false
is: http://identifiers.org/pubchem.compound/3310
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01341

metaR r0295
type: Reaction
is: SBO:0000176
product: MODEL1310110056#
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
modifier: MODEL1310110056#
is described by: ECO:0000000
reversible: false
fast: false
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_e0ee599a_d93d_4676_ab2b_f053403142f2
initial amount: NaN
has only substance units: false
is encoded by: hsa:5320
initial concentration: NaN
constant: false
is: SBO:0000252
name: PLA2G2A
is: P14555
type: Species
boundary condition: true

metaR r0170
is described by: ECO:0000000
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.40
product: MODEL1310110056#
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
reactant: MODEL1310110056#

metaR MI145PP
is version of: http://identifiers.org/ec-code/3.1.3.86
modifier: MODEL1310110056#
fast: false
type: Reaction
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.36
is version of: http://identifiers.org/ec-code/3.1.3.56
name: inositol-1,4,5-trisphosphate 5-phosphatase
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
reversible: false
is described by: ECO:0000269

metaM CE2422 m
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
is: HMDB11123
is: CHEBI:28387
has only substance units: false

metaM pro L c
is: CHEBI:17203
is: HMDB00162
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
name: L-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial amount: NaN
boundary condition: false

metaM 3tetd7ecoacrn e
is: HMDB02014
is: SBO:0000247
has only substance units: false
name: 3-hydroxy tetradecenoyl-7-carnitine
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C21H39NO5 CHARGE: 0
type: Species
boundary condition: false

metaM coa l
is: HMDB01423
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:57287
constant: false
initial amount: NaN
initial concentration: 1.0
name: coenzyme A(4-)

metaM 6dhf e
initial concentration: 1.0
initial amount: NaN
name: hexaglutamyl folate (DHF)
type: Species
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
is: HMDB06563

http://identifiers.org/biomodels.db/MODEL1310110056#_aff3f9de_df95_4217_956a_0ad6fd17fdaf
is encoded by: hsa:NM 013421
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: _NM_013421_1_m
constant: false
type: Species
has only substance units: false
is: SBO:0000252

metaR FACOAL241
modifier: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110056#_719e6b47_f6a7_40f8_80df_94b5eccb39cd
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:AI684467
name: _AI684467_1_m
type: Species
boundary condition: true
initial amount: NaN

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaR PRPNCOAHYDm
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/4.2.1.18
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Propenoyl-CoA hydrolase (m)
is described by: ECO:0000134
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
product: MODEL1310110056#

metaR EX lpchol hs LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lysophosphatidylcholine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_e60e53d7_1ac5_497d_b506_312a17d6aa50
boundary condition: true
constant: false
is: Q92959
type: Species
name: SLCO2A1
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:6578

http://identifiers.org/biomodels.db/MODEL1310110056#_3f3c8148_b662_4c31_aa96_93e6e1cd724d
is: SBO:0000252
type: Species
is: Q9Y2Q0
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:10396
name: ATP8A1

metaR ALACYSNaEx
modifier: MODEL1310110056#
is: SBO:0000185
fast: false
reversible: false
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)
reactant: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaM 3snpyr m
is: SBO:0000247
constant: false
type: Species
is: HMDB02332
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
is: CHEBI:1665
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: 3-Sulfinopyruvate
has only substance units: false

metaM coa m
is: SBO:0000247
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
constant: false
name: Coenzyme A
is: C00010
type: Species
initial concentration: 1.0
is: CHEBI:57287
initial amount: NaN
is: HMDB01423
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_3a695017_d890_40fc_9909_e7b2c0fe3b0b
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10327
name: AKR1A1
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252

metaR SUCCt4 2
name: succinate transport via sodium symport
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
reactant: MODEL1310110056#
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
fast: false
is: SBO:0000185

metaM udpacgal c
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57847
is: HMDB00304
name: UDP-N-acetyl-D-galactosamine(2-)
initial amount: NaN
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_b440d508_5aba_4004_8bcb_406f78eef8ca
is encoded by: hsa:AV727634
is: SBO:0000252
name: _AV727634_1_c
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true

metaM arachcoa e
initial concentration: 1.0
is: CHEBI:15527
has only substance units: false
constant: false
type: Species
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: HMDB04258
boundary condition: false
is: SBO:0000247
name: arachidyl coenzyme A
initial amount: NaN

metaR MACACI
is version of: http://identifiers.org/ec-code/2.5.1.18
type: Reaction
product: MODEL1310110056#
name: maleylacetoacetate isomerase
is: SBO:0000176
kinetic law: MODEL1310110056#
is described by: ECO:0000269
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
reversible: false
fast: false
modifier: MODEL1310110056#

metaM 3octdece1coa c
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
name: 3-hydroxyoctadecenoylcoa
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB13336

metaM retinol c
initial amount: NaN
boundary condition: false
is: HMDB00305
constant: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: SBO:0000247
is: CHEBI:50211
name: retinol
has only substance units: false
initial concentration: 1.0
type: Species

metaR RE3421R
fast: false
reversible: true
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
name: RE3421
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_5c294cca_9155_4c67_b99f_dbf70c43f9c1
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
name: GUSB
is: P08236
is encoded by: hsa:2990

http://identifiers.org/biomodels.db/MODEL1310110056#_9095b45d_1a95_45da_a38a_b9a2dd117e93
name: ADCY7
initial amount: NaN
has only substance units: false
is encoded by: hsa:113
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: P51828

metaR TMNDNCCPT2
reversible: false
type: Reaction
reactant: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110056#
name: carnitine transferase

metaM tre e
is: SBO:0000247
is: HMDB00975
is: C01083
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
type: Species
boundary condition: false
is: CHEBI:16551
name: Trehalose
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_18111728_634b_49f4_b53e_86161be6a255
constant: false
is encoded by: hsa:4702
name: NDUFA8
initial concentration: NaN
boundary condition: true
has only substance units: false
is: B1AM93
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_3586fcd1_39cc_431d_b2cc_3670c1ba16dd
name: NDUFB5
boundary condition: true
type: Species
has only substance units: false
is: O43674
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:4711

metaR r2124
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110056#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_8dc3e446_ab61_459c_a876_909d443ff51c
is encoded by: hsa:4645
is: Q9H6Y6
has only substance units: false
name: MYO5B
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR H2Otly
name: H2O transport, lysosomal
reversible: true
kinetic law: MODEL1310110056#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110056#
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_5c869481_31e9_42df_88cd_514028cc4d44
is: Q99807
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10229
type: Species
boundary condition: true
name: COQ7
initial concentration: NaN
initial amount: NaN

metaR C4STMO2Pr
is version of: http://identifiers.org/ec-code/1.1.1.170
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
product: MODEL1310110056#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110056#
reactant: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
name: C-4 methyl sterol oxidase
is described by: ECO:0000000
reversible: false

metaR ACACt2m
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
type: Reaction
name: Acetoacetate mitochondrial transport via H+ symport
is described by: ECO:0000269
product: MODEL1310110056#
reactant: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
is: SBO:0000185
reversible: true

metaR LEUKTRD4t
is: SBO:0000185
fast: false
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
type: Reaction
reactant: MODEL1310110056#
name: leukotriene D4 transport

metaM eitetcoa x
boundary condition: false
constant: false
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: 5,8,11,14-eicosatetraenoylcoa
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790

http://identifiers.org/biomodels.db/MODEL1310110056#_56df763e_de9a_4c52_a565_7c5723ed2481
is encoded by: hsa:28976
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q9H845
boundary condition: true
constant: false
type: Species
name: ACAD9

metaR C10OHc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdecanoylcarnitinec
type: Reaction

metaM hpdcacrn c
boundary condition: false
type: Species
initial amount: NaN
is: HMDB06210
name: heptadecanoyl carnitine
has only substance units: false
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR C160CRNt
name: C160 transport into the mitochondria
type: Reaction
fast: false
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
product: MODEL1310110056#
reversible: false
modifier: MODEL1310110056#

metaR r2123
reversible: true
kinetic law: MODEL1310110056#
product: MODEL1310110056#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110056#
fast: false
modifier: MODEL1310110056#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000

metaM n2m2nmasn l
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: C04946
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C58H96N5O40X CHARGE: 0
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
type: Species

metaR GPIDA2er
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: false
modifier: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD

metaM CE2432 m
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
is: CHEBI:57795
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
type: Species

metaR VD3
name: Vitamin D3 formation
fast: false
type: Reaction
reversible: true
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
kinetic law: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110056#

metaR 3SALAASPm
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
is described by: ECO:0000304
modifier: MODEL1310110056#
name: cysteinesulfinate-aspartate mitochondrial shuttle
type: Reaction
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#

metaR RE0926E
product: MODEL1310110056#
reactant: MODEL1310110056#
reversible: true
name: RE0926
fast: false
kinetic law: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.17
is: SBO:0000176
modifier: MODEL1310110056#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.1

metaR CYSGLNNaEx
fast: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000185
modifier: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000269
name: L-cysteine/L-glutamine Na-dependent exchange (Cys-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
reversible: false

metaM 34hpl m
boundary condition: false
has only substance units: false
is: HMDB00755
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:36659
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8,10-11H,5H2,(H,12,13)/p-1
name: 3-(4-hydroxyphenyl)lactate

metaM ipdp c
initial amount: NaN
name: Isopentenyl diphosphate
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
is: C00129
boundary condition: false
type: Species
is: CHEBI:128769
is: HMDB01347
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0

metaR r2122
product: MODEL1310110056#
reactant: MODEL1310110056#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110056#
fast: false
type: Reaction
modifier: MODEL1310110056#
is described by: ECO:0000000

metaR r0191
type: Reaction
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
is: SBO:0000176
modifier: MODEL1310110056#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.24
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
product: MODEL1310110056#
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
fast: false
reversible: false

metaR C4tmc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine into mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_f1e479f3_d079_4b50_99b0_1b18f1e6fdfa
constant: false
has only substance units: false
is encoded by: hsa:11001
is: O14975
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: SLC27A2

metaR r2408
is: SBO:0000185
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reactant: MODEL1310110056#
product: MODEL1310110056#
fast: false
type: Reaction

metaM malcoa r
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB01175
type: Species
boundary condition: false
is: CHEBI:57384
has only substance units: false
initial concentration: 1.0
name: malonyl-CoA(4-)
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083

metaR TMNDNCCPT1
name: carnitine O-palmitoyltransferase
reactant: MODEL1310110056#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
product: MODEL1310110056#
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110056#_1bd30ab7_71fc_49ce_8ed4_84abfed16f2e
is encoded by: hsa:765
initial concentration: NaN
is: Q5FC00
has only substance units: false
constant: false
type: Species
boundary condition: true
initial amount: NaN
name: CA6
is: SBO:0000252

metaR r2121
is: SBO:0000185
type: Reaction
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110056#
fast: false
reversible: true
product: MODEL1310110056#
reactant: MODEL1310110056#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM strdnccoa m
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: HMDB06519
initial amount: NaN
boundary condition: false
name: stearidonyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205473
is: C16163
constant: false

metaR FAOXC12C10m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_35be4291_c74f_49d4_9ff0_cc366eb6d967
is encoded by: hsa:6391
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: SDHC
constant: false
initial amount: NaN
is: Q99643

metaR DNDPt33m
is: SBO:0000185
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110056#
product: MODEL1310110056#
modifier: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dGDP transport via dUDP antiport

http://identifiers.org/biomodels.db/MODEL1310110056#_126b44ba_93ec_4b3b_905b_305abfff1168
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:81031
is: O95528
initial concentration: NaN
has only substance units: false
name: SLC2A10
boundary condition: true

metaM methf m
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
name: (6R)-5,10-methenyltetrahydrofolate
is: CHEBI:57455
initial amount: NaN
constant: false
boundary condition: false
is: HMDB01354

metaM Tn antigen g
type: Species
notes: FORMULA: C8H14NO5X CHARGE: 0
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: C04383
is: SBO:0000247
name: Tn antigen

metaR M13N2Tg
is version of: http://identifiers.org/ec-code/2.4.1.101
product: MODEL1310110056#
fast: false
reactant: MODEL1310110056#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
reversible: false
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
is: SBO:0000176
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_31fedc65_a980_4c16_95c5_3cad5efc6e6c
initial concentration: NaN
is encoded by: hsa:26063
initial amount: NaN
has only substance units: false
is: Q9NUI1
name: DECR2
constant: false
is: SBO:0000252
boundary condition: true
type: Species

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

metaM adp c
boundary condition: false
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/3310
is: CHEBI:16761
is: SBO:0000247
name: ADP
has only substance units: false
is: HMDB01341
initial amount: NaN
is: C00008
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_4d353ab7_4aa7_4c33_a0ea_d7f909e3bda1
is: SBO:0000252
is encoded by: hsa:5052
has only substance units: false
initial concentration: NaN
is: Q06830
boundary condition: true
name: PRDX1
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_7720a050_89a1_49dc_9e2b_079a67b296f4
type: Species
initial amount: NaN
name: BTD
has only substance units: false
initial concentration: NaN
constant: false
is: P43251
boundary condition: true
is encoded by: hsa:686
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_612f8fde_2b68_4b30_8f6c_86ea9d71f2d6
initial concentration: NaN
is: Q13946
boundary condition: true
is encoded by: hsa:5150
name: PDE7A
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species

metaR r2120
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110056#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_6d86cb40_6811_46e8_8bee_2aaee0370ecd
type: Species
name: FUCA1
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is: P04066
boundary condition: true
is encoded by: hsa:2517

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

metaM ksii core2 pre8 g
initial concentration: 1.0
initial amount: NaN
is: HMDB00175
is: C00130
notes: FORMULA: C75H121N6O56SX CHARGE: -2
has only substance units: false
type: Species
is: CHEBI:58053
boundary condition: false
constant: false
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 8

http://identifiers.org/biomodels.db/MODEL1310110056#_66f26a9a_0d01_4f3d_943e_abece5641f43
name: PGM2
has only substance units: false
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:55276
is: Q96G03

metaM decdp m
type: Species
boundary condition: false
initial concentration: 1.0
name: all trans Decaprenyl diphosphate
has only substance units: false
notes: FORMULA: C50H81O7P2 CHARGE: -3 INCHI: InChI=1/C50H90O7P2/c1-41(2)21-31-53-58(51,54-32-22-42(3)4)57-59(52,35-25-45(9)10,36-26-46(11)12,37-27-47(13)14,38-28-48(15)16,39-29-49(17)18,40-30-50(19)20,55-33-23-43(5)6)56-34-24-44(7)8/h21-30H,31-40H2,1-20H3
initial amount: NaN
is: SBO:0000247
is: HMDB06288
constant: false

metaM 2mop c
is: SBO:0000247
is: CHEBI:57700
is: HMDB01172
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
name: 2-methyl-3-oxopropanoate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_acd4818c_4ef4_4a73_b276_473c3b598f7e
boundary condition: true
name: _AI091231_1_c
constant: false
is encoded by: hsa:AI091231
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR S6T14g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110056#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110056#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
product: MODEL1310110056#
modifier: MODEL1310110056#
reversible: false

metaR MG1er
product: MODEL1310110056#
reversible: false
reactant: MODEL1310110056#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.106
is: SBO:0000176
kinetic law: MODEL1310110056#
fast: false
modifier: MODEL1310110056#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum

metaR r1454
is: SBO:0000185
type: Reaction
fast: false
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
product: MODEL1310110056#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110056#_19ead6a3_344c_4881_be7a_1d2710175113
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:2348
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: FOLR1

metaR FACOAL226
is described by: ECO:0000000
name: fatty-acid--CoA ligase
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110056#
reversible: true

metaM gam6p c
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
initial concentration: 1.0
constant: false
is: HMDB01254
has only substance units: false
type: Species
is: CHEBI:12962
name: D-Glucosamine 6-phosphate
boundary condition: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_519a7449_3e3f_49b7_9857_02f9c29ceee4
name: ATP10A
is: SBO:0000252
is encoded by: hsa:57194
is: O60312
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false

metaM ura c
is: SBO:0000247
initial amount: NaN
is: C00106
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: HMDB00300
is: CHEBI:17568
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
name: Uracil
type: Species

metaR TETPENT3t
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000000
reversible: true
name: fatty acid transport via diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
fast: false

metaM cl e
constant: false
name: Chloride
notes: FORMULA: Cl CHARGE: -1
is: HMDB00492
is: SBO:0000247
is: CHEBI:3966
is: C00115
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0

metaM retinol e
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:50211
boundary condition: false
type: Species
is: HMDB00305
is: SBO:0000247
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
name: retinol
has only substance units: false

metaM HC02180 e
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: thromboxane-b2
is: CHEBI:28728
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963

metaR r1453
kinetic law: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
is described by: ECO:0000000
product: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
is: SBO:0000176
reversible: true

metaM r1p c
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: C00442
boundary condition: false
is: HMDB01489
type: Species
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
name: alpha-D-Ribose 1-phosphate
is: CHEBI:57720

metaM hmgcoa m
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:15467
boundary condition: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
has only substance units: false
is: HMDB01375
name: Hydroxymethylglutaryl-CoA
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110056#_84add0ce_2033_401d_91fc_ec177e7b4c32
boundary condition: true
is: Q5QPH3
name: ACSS2
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:55902
is: SBO:0000252
initial amount: NaN

metaM c12dc x
name: dodecanedioyl carnitine
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C19H34NO6 CHARGE: -1
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB11123
is: C05279
has only substance units: false

metaR NRPPHRt4 2 r
kinetic law: MODEL1310110056#
is described by: ECO:0000269
modifier: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
reversible: true
name: Norepinephrine reversible transport in via sodium symport (1:2)

metaM pro L m
name: L-proline
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00162
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: SBO:0000247
boundary condition: false
is: CHEBI:17203

metaR PHCDm
fast: false
type: Reaction
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
kinetic law: MODEL1310110056#
reversible: false
is described by: ECO:0000304
modifier: MODEL1310110056#
product: MODEL1310110056#
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
is version of: http://identifiers.org/ec-code/1.5.1.12
is: SBO:0000176

metaR sink decdicoa LPAREN c RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Sink for 2,6-dodecadienoylcoa(c)
type: Reaction

metaM andrstrn r
constant: false
is: SBO:0000247
is: CHEBI:16032
type: Species
name: androsterone
is: HMDB00031
boundary condition: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR FACOAL224
name: fatty-acid--CoA ligase
is described by: ECO:0000000
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
product: MODEL1310110056#
is: SBO:0000176
reversible: true
type: Reaction

metaM CE2435 m
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
initial amount: NaN
name: trans,cis-deca-2,4-dienoyl-CoA
type: Species
initial concentration: 1.0
is: CHEBI:57795
has only substance units: false

metaR ACACT4p
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110056#
name: acetyl-CoA C-acetyltransferase (octanoyl-CoA), peroxisomal
reversible: false
fast: false
modifier: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD

metaR S6TASE22ly
fast: false
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110056#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: true
product: MODEL1310110056#
type: Reaction
name: galactose-6-sulfate sulfatase, lysosomal

metaR DNDPt12m
reversible: false
name: dADP transport via ADP antiport
type: Reaction
fast: false
product: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110056#
is: SBO:0000185
reactant: MODEL1310110056#

metaR ABUTt2r
reversible: true
is: SBO:0000185
modifier: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
name: 4-aminobutyrate reversible transport in via proton symport
is described by: ECO:0000304
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r

metaM glu L m
initial concentration: 1.0
is: HMDB00148
boundary condition: false
is: CHEBI:29985
name: L-glutamate(1-)
has only substance units: false
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025

metaM ura e
is: HMDB00300
name: uracil
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: CHEBI:17568
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN

metaM hs deg14 l
constant: false
name: heparan sulfate, degradation product 14
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:16126
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM hista e
name: histamium
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00870
constant: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
has only substance units: false
is: CHEBI:58432

http://identifiers.org/biomodels.db/MODEL1310110056#_110eef28_9d61_4602_a9d0_144ca776ab2d
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: _AI469183_1_x
constant: false
is encoded by: hsa:AI469183
initial amount: NaN
boundary condition: true
type: Species

metaM ksi deg8 l
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
type: Species
constant: false
name: keratan sulfate I, degradation product 8
is: CHEBI:12936
is: SBO:0000247
is: HMDB00143
initial amount: NaN

metaR EX glygly LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for glycylglycine
type: Reaction

metaR r1564
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM HC02180 c
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
initial amount: NaN
constant: false
boundary condition: false
name: thromboxane-b2
type: Species
initial concentration: 1.0
is: CHEBI:28728
has only substance units: false
is: SBO:0000247

metaM etfrd m
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00151
is: SBO:0000247
type: Species
name: Electron transfer flavoprotein reduced
has only substance units: false
notes: FORMULA: RH2 CHARGE: 0
initial concentration: 1.0
is: CHEBI:16469

http://identifiers.org/biomodels.db/MODEL1310110056#_679f7d2b_cb75_43cc_925f_81fecd425391
is encoded by: hsa:AU149534
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
name: _AU149534_1_c
type: Species
is: SBO:0000252
constant: false

metaM 4abut m
is: HMDB00112
constant: false
boundary condition: false
type: Species
is: C00334
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
is: SBO:0000247
is: CHEBI:16865
initial amount: NaN
has only substance units: false
name: 4-Aminobutanoate

metaR r2403
reactant: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110056#
is: SBO:0000185
product: MODEL1310110056#
reversible: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
fast: false

metaM dttp e
boundary condition: false
type: Species
is: CHEBI:37568
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01342
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
name: dTTP(4-)

metaR FAOXC12DCc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: formation of dodecanedioyl carnitine
type: Reaction

metaR ETFQO
is version of: http://identifiers.org/ec-code/1.5.5.1
modifier: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
product: MODEL1310110056#

metaR FAOXC2452256x
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:5,n-6 -> c22:5, n-6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
name: Beta oxidation of long chain fatty acid
product: MODEL1310110056#
reversible: false

metaM trp L c
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: SBO:0000247
has only substance units: false
name: L-tryptophan
is: HMDB00929
boundary condition: false
constant: false
type: Species
is: CHEBI:16828
initial concentration: 1.0
initial amount: NaN

metaM pcrn x
is: HMDB00824
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: propionyl-carnitine
constant: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/107738

metaM ksii core2 e
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:17268
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
initial amount: NaN
is: HMDB00211
type: Species
constant: false
is: SBO:0000247
name: keratan sulfate II (core 2-linked)

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaM 4abut n
is: C00334
initial concentration: 1.0
is: SBO:0000247
name: 4-Aminobutanoate
has only substance units: false
boundary condition: false
is: HMDB00112
initial amount: NaN
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0
constant: false

metaR METtec
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
fast: false
type: Reaction
reversible: true
name: L-methionine transport via diffusion (extracellular to cytosol)
is: SBO:0000185
product: MODEL1310110056#
is described by: ECO:0000269
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#

metaR r1563
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#

metaR AHCYStd
type: Reaction
fast: false
name: diffusion of S-Adenosyl-L-homocysteine
reactant: MODEL1310110056#
product: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
is described by: ECO:0000134
reversible: true
is: SBO:0000185

metaM dcyt n
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
name: 2'-deoxycytidine
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00014
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: CHEBI:15698

metaM Tn antigen l
initial concentration: 1.0
is: C04383
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C8H14NO5X CHARGE: 0
name: Tn antigen
boundary condition: false

metaM glu L r
is: CHEBI:29985
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
has only substance units: false
type: Species
name: L-glutamate(1-)
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00148

metaR EX elaid LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: elaidic acid exchange
type: Reaction

metaM hista c
constant: false
name: histamium
is: CHEBI:58432
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00870

metaR r2401
product: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reactant: MODEL1310110056#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
reversible: false

metaR AHCYSte
name: Transport of S-adenosyl-L-homocysteine
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110056#
is: SBO:0000185

metaR r1562
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
kinetic law: MODEL1310110056#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM 3docopencoa m
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
name: 3,7,10,13,16-docosapentenoylcoa
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790

metaR DOCO13EFATP
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: absorption or uptake of 13-docosenoic acid into cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_c1c48fe2_bcac_4300_81b6_b88033f7b5a3
type: Species
initial amount: NaN
name: SLC4A5
is: SBO:0000252
is encoded by: hsa:57835
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_339cd3ba_684b_4e30_9b31_1570f29b369b
constant: false
boundary condition: true
type: Species
name: PANK2
initial amount: NaN
is encoded by: hsa:80025
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM methf c
is: HMDB01354
is: CHEBI:57455
boundary condition: false
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: C00445
initial amount: NaN
name: 5,10-Methenyltetrahydrofolate

metaR PAPStg
reversible: true
is: SBO:0000185
is described by: ECO:0000269
name: 3'-Phosphoadenylyl sufate Golgi transport
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
type: Reaction
product: MODEL1310110056#

metaM trp L e
initial concentration: 1.0
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
has only substance units: false
is: HMDB00929
name: L-tryptophan
constant: false
type: Species
boundary condition: false
is: CHEBI:16828
initial amount: NaN
is: SBO:0000247

metaM ksii core2 g
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57255
name: keratan sulfate II (core 2-linked)
has only substance units: false
boundary condition: false
is: HMDB01014

http://identifiers.org/biomodels.db/MODEL1310110056#_49aca6cc_0b2c_43cf_8dcd_00390cbc24b1
is encoded by: hsa:4708
boundary condition: true
constant: false
is: H7C5B8
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: NDUFB2
initial amount: NaN

metaM lneldccoa c
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/9543677
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
type: Species
name: linoelaidyl coenzyme A
has only substance units: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
is: HMDB06521

metaR r0829
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.37
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reversible: true
reactant: MODEL1310110056#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaR r1561
fast: false
reactant: MODEL1310110056#
product: MODEL1310110056#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM mi1p D c
boundary condition: false
is: SBO:0000247
name: 1D-myo-inositol 1-phosphate(2-)
initial amount: NaN
is: HMDB02985
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
initial concentration: 1.0
is: CHEBI:58433
has only substance units: false
constant: false

metaM core2 g
initial concentration: 1.0
is: SBO:0000247
name: Core 2
notes: FORMULA: C22H37N2O15X CHARGE: 0
type: Species
boundary condition: false
is: CHEBI:15876
has only substance units: false
constant: false
initial amount: NaN

metaM 2mop m
is: HMDB01172
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:57700
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
constant: false
name: 2-methyl-3-oxopropanoate
has only substance units: false
type: Species

metaR PLA2 2
type: Reaction
reversible: false
is: SBO:0000176
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.1.4
fast: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000000
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (8398.1) or (5320.1) or (8398.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:9272153,PMID:9417066 NOTES:phosphatidyl choline degradation NJ
name: phospholipase A2

http://identifiers.org/biomodels.db/MODEL1310110056#_711842d8_9a54_4436_8573_c9d41e5c2a3b
type: Species
is encoded by: hsa:AA854479
constant: false
name: _AA854479_1_m
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_1f323b22_d22b_454d_b281_ef514b7871f9
initial concentration: NaN
type: Species
is encoded by: hsa:374907
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
name: B3GNT8

metaR r2129
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110056#
is: SBO:0000185
reversible: true
product: MODEL1310110056#
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000

metaM ptdcacrn m
has only substance units: false
name: pendtadenoyl carnitine
is: SBO:0000247
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:18303
initial amount: NaN
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1

metaM ach n
constant: false
type: Species
is: CHEBI:15355
is: SBO:0000247
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
name: acetylcholine
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00895
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_65cf51cb_9115_4318_afd5_8a8710dd6403
boundary condition: true
is encoded by: hsa:6240
is: SBO:0000252
initial amount: NaN
is: P23921
constant: false
type: Species
name: RRM1
initial concentration: NaN
has only substance units: false

metaR r1560
product: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110056#

metaR FAOXC225C226x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

W3 CDTF: Thu Aug 30 14:35:47 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110056#_ac39c829_9244_4e7d_baca_f923110ca6ef
is: SBO:0000252
type: Species
is: Q16720
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:492
boundary condition: true
name: ATP2B3
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_3f12d64f_fb0e_4168_ab23_82de6d394034
type: Species
constant: false
is: Q9Y233
name: PDE10A
initial amount: NaN
is encoded by: hsa:10846
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR r2128
reactant: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110056#
reversible: true
fast: false
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110056#

metaR DCTPtn
name: dCTP diffusion in nucleus
product: MODEL1310110056#
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_bbcdf3bf_dad6_42ba_a116_8f128f136ad7
has only substance units: false
is: SBO:0000252
is encoded by: hsa:56953
constant: false
type: Species
boundary condition: true
name: NT5M
initial amount: NaN
is: Q9NPB1
initial concentration: NaN

metaR r0081
fast: false
reactant: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000176
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.12
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#

metaM odecoa x
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB01322
name: oleoyl-CoA(4-)
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
is: CHEBI:57387

metaM 3otdcoa m
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB03935
is: CHEBI:28726
is: SBO:0000247
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
type: Species
name: 3-Oxotetradecanoyl-CoA
initial amount: NaN
boundary condition: false

metaR SUCCTD
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaR r2127
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
reversible: true
reactant: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR C30CPT1
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of propionylcarnitine
type: Reaction

metaM dcsptn1 e
type: Species
name: docosa-4,7,10,13,16-pentaenoic acid
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB13123
is: http://identifiers.org/pubchem.compound/5282848
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-

metaM Rtotalcoa c
boundary condition: false
is: CHEBI:16189
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB01448
initial amount: NaN
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
has only substance units: false
type: Species
name: R total Coenzyme A

metaM hmgcoa x
is: CHEBI:15467
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
name: Hydroxymethylglutaryl-CoA
is: HMDB01375
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
type: Species

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaM strdnccoa x
name: stearidonyl coenzyme A
is: HMDB06519
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: http://identifiers.org/pubchem.compound/47205473
has only substance units: false
initial amount: NaN
is: C16163

W3 CDTF: Thu Aug 30 14:35:46 BST 2012

metaM saccrp L m
notes: FORMULA: C11H19N2O6 CHARGE: -1 INCHI: InChI=1S/C11H20N2O6/c12-7(10(16)17)3-1-2-6-13-8(11(18)19)4-5-9(14)15/h7-8,13H,1-6,12H2,(H,14,15)(H,16,17)(H,18,19)/p-1/t7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00363
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57951
boundary condition: false
has only substance units: false
name: L-saccharopinate(1-)
is: HMDB00279
constant: false
initial amount: NaN
type: Species

metaR r0082
product: MODEL1310110056#
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.6.1.2
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reversible: true
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (2875.1) or (84706.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:

metaR r2126
reversible: true
reactant: MODEL1310110056#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000000
kinetic law: MODEL1310110056#
fast: false

metaM hs deg20 l
has only substance units: false
type: Species
name: heparan sulfate, degradation product 20
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16126
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
initial concentration: 1.0

metaR OCTDECE1CRNe
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-octadecenoyl carnitine into extra cellular space
type: Reaction

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_7dc1758b_9065_46c6_b99c_7b306d29161a
is encoded by: hsa:131669
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
name: UROC1
is: SBO:0000252
is: Q68CJ7
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_eba5fe12_19d2_4ce8_bab4_cf493e6b3c8d
boundary condition: true
is encoded by: hsa:6487
initial amount: NaN
is: SBO:0000252
name: ST3GAL3
has only substance units: false
constant: false
initial concentration: NaN
type: Species

metaM arachcoa x
is: CHEBI:15527
boundary condition: false
has only substance units: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
name: arachidyl coenzyme A
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
is: HMDB04258

metaR RAI1
is: SBO:0000176
type: Reaction
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000
reversible: true
name: retinal isomerase (11-cis)
fast: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

metaR PNTEH
type: Reaction
kinetic law: MODEL1310110056#
is: SBO:0000176
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.5.1.92
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
reactant: MODEL1310110056#
fast: false
is described by: ECO:0000269
reversible: false
product: MODEL1310110056#
name: Hydrolase Class ( RXN R02973)

metaM gacpail hs c
has only substance units: false
constant: false
type: Species
is: SBO:0000247
name: glucosaminyl-acylphosphatidylinositol
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: HMDB01401
is: CHEBI:61548
is: C00092

metaM Sfglutth c
constant: false
is: CHEBI:57688
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB01550
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
name: S-formylglutathionate(1-)
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM lanost r
boundary condition: false
type: Species
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB01251
is: SBO:0000247
has only substance units: false
is: CHEBI:16521
name: lanosterol

http://identifiers.org/biomodels.db/MODEL1310110056#_0985d50b_e8a9_4370_a925_12e5a840d1ed
has only substance units: false
is: SBO:0000252
is encoded by: hsa:197257
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
name: LDHD
type: Species

W3 CDTF: Thu Aug 30 14:35:47 BST 2012

metaR r2125
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#

metaR r0083
modifier: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.42
product: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
fast: false
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42

metaM doldp U r
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C1025H1670O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
name: Dolichol diphosphate, human uterine homolog
initial concentration: 1.0
is: CHEBI:15750
initial amount: NaN
has only substance units: false
type: Species

metaM hpdcacrn m
type: Species
boundary condition: false
is: SBO:0000247
name: heptadecanoyl carnitine
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB06210
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_b7d64b58_49f6_47e4_b14f_4dd13676f19a
constant: false
boundary condition: true
name: NAGLU
has only substance units: false
is: P54802
is encoded by: hsa:4669
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

metaR RAI2
fast: false
is: SBO:0000176
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110056#
name: retinal isomerase (9-cis)
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_b7e22fed_0f45_4b15_acdb_8641f653388b
constant: false
name: _AA177072_1_c
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AA177072
is: SBO:0000252
type: Species
boundary condition: true

metaR HIVCRNe
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-isovaleryl carnitine into extra cellular space
type: Reaction

metaR NDP10ex
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
is: SBO:0000176
product: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.6
name: nucleoside-diphosphatase (IDP), extracellular
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#

metaR MAN6PI
is described by: ECO:0000304
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/5.3.1.8
modifier: MODEL1310110056#
type: Reaction
is: SBO:0000176
product: MODEL1310110056#
name: mannose-6-phosphate isomerase
fast: false
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
reversible: true

metaR r0392
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
kinetic law: MODEL1310110056#
product: MODEL1310110056#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
type: Reaction
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110056#

metaR RPI
product: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
modifier: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.1.6
type: Reaction
reversible: true
name: ribose-5-phosphate isomerase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP

metaM acgal l
name: N-acetyl-D-galactosamine
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
is: CHEBI:28037
is: HMDB00212
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0

metaR r0287
reactant: MODEL1310110056#
product: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110056#_d72536e4_1bd7_4039_bcd9_962fb70dadcc
has part: E9PB82
is encoded by: hsa:3295
initial concentration: NaN
is: SBO:0000297
has only substance units: false
name: ACAA1:HSD17B4:ACOX1
type: Species
initial amount: NaN
boundary condition: true
constant: false

metaR DMATTx
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
type: Reaction
name: dimethylallyltranstransferase
modifier: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.1
product: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
reversible: false
is described by: ECO:0000134

metaR AG13T2g
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
reactant: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110056#
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_c1c9578c_45d4_4e25_8da1_9d77723b800e
type: Species
boundary condition: true
is: SBO:0000252
name: SLC3A2
is: P08195
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6520

http://identifiers.org/biomodels.db/MODEL1310110056#_0c6601f0_f3d8_403c_b8d4_2947b90afdda
boundary condition: true
is: SBO:0000252
name: SLC8A3
is: B3KU59
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6547
type: Species

metaM xu5p D c
name: D-xylulose 5-phosphate(2-)
initial concentration: 1.0
type: Species
is: HMDB00868
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
is: CHEBI:57737
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_54243cda_7c02_405b_bd1c_71c474242ec9
is encoded by: hsa:26330
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: O14556
name: GAPDHS
has only substance units: false
boundary condition: true
type: Species
constant: false

metaR DCK2n
is: SBO:0000176
reactant: MODEL1310110056#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.1.74
type: Reaction
product: MODEL1310110056#
fast: false
name: Deoxycytidine kinase, nuclear (UTP)
modifier: MODEL1310110056#

metaR C4CRNe
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of butyryl carnitine into the extra cellular space
type: Reaction

metaR AG13T11g
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
reversible: false
is: SBO:0000176

metaM dcyt e
is: C00881
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
name: Deoxycytidine
is: HMDB00014
is: CHEBI:15698
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881

http://identifiers.org/biomodels.db/MODEL1310110056#_6fa04bd4_8b4e_4f18_81bf_5954ee3dad02
initial concentration: NaN
is encoded by: hsa:4538
is: P03905
boundary condition: true
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ND4

metaM dttp n
initial concentration: 1.0
constant: false
name: dttp[n]
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: CHARGE: 0
initial amount: NaN
is: HMDB01342
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_d97e9c20_b0f4_4412_9366_59c48dc950e0
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
name: CHST1
has only substance units: false
is: O43916
is encoded by: hsa:8534
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_c67e1c99_6a1c_49ec_8157_3e02ad995672
is encoded by: hsa:4728
boundary condition: true
is: O00217
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: NDUFS8
initial concentration: NaN

metaM g3p c
boundary condition: false
is: SBO:0000247
is: C00661
initial amount: NaN
constant: false
type: Species
is: HMDB01112
has only substance units: false
is: http://identifiers.org/pubchem.compound/3930
is: CHEBI:58027
name: Glyceraldehyde 3-phosphate
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
initial concentration: 1.0

metaR r1569
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110056#
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110056#
fast: false

metaR r0394
type: Reaction
product: MODEL1310110056#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
kinetic law: MODEL1310110056#
reversible: true
fast: false
is described by: ECO:0000000
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reactant: MODEL1310110056#

metaM sphmyln hs g
boundary condition: false
initial amount: NaN
is: CHEBI:58216
is: SBO:0000247
initial concentration: 1.0
name: sphingomyelin betaine
has only substance units: false
type: Species
constant: false
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007

http://identifiers.org/biomodels.db/MODEL1310110056#_f022f537_8e71_41ed_aee9_5964693c245a
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: SLC25A10
is: Q9UBX3
is encoded by: hsa:1468
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_cfa5e562_e5a4_44b7_a939_a6bb1e18f05b
has only substance units: false
type: Species
is encoded by: hsa:26266
is: Q9UKG4
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
name: SLC13A4

metaM dad 2 c
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
constant: false
name: 2-deoxyadenosine
is: HMDB00101
is: CHEBI:17256
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_c80c8131_ea25_4a32_9f1f_1e49ad11f6b5
initial amount: NaN
name: GMPR2
boundary condition: true
has only substance units: false
is encoded by: hsa:51292
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_8a76e6d3_da54_46dd_b847_daf2a56502f9
has only substance units: false
is encoded by: hsa:2348
type: Species
boundary condition: true
constant: false
initial concentration: NaN
name: FOLR1
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_6a8bd8ee_6ee2_485c_94d2_ba5242f7b594
name: ASRGL1
is: SBO:0000252
type: Species
has only substance units: false
is: Q7L266
constant: false
is encoded by: hsa:80150
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR FAOXC225C226m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

metaM orn m
is: CHEBI:46912
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00214
is: SBO:0000247
name: Ornithine
notes: FORMULA: C5H13N2O2 CHARGE: 1
has only substance units: false
initial amount: NaN
is: C01602
constant: false

metaR r0393
reactant: MODEL1310110056#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000000
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.1.74
fast: false

metaM c12dc c
constant: false
name: dodecanedioyl carnitine
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00623
initial concentration: 1.0
notes: FORMULA: C19H34NO6 CHARGE: -1
initial amount: NaN
type: Species

metaR ASPTA
type: Reaction
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
modifier: MODEL1310110056#
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
fast: false
name: aspartate transaminase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
product: MODEL1310110056#

metaR r0074
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.1
reactant: MODEL1310110056#
modifier: MODEL1310110056#
reversible: true
kinetic law: MODEL1310110056#
fast: false
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110056#_e9fe7d1d_1c81_4fd2_8fc3_d83bbca842e9
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:1962
initial amount: NaN
is: Q9NY65
name: EHHADH
boundary condition: true
constant: false

metaR GUAt
is: SBO:0000185
reversible: true
product: MODEL1310110056#
fast: false
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
name: Guanine transport
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110056#_8cc1318a_3013_4dfd_9cd8_d19e4e4c9570
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:AI934540
name: _AI934540_1_c

http://identifiers.org/biomodels.db/MODEL1310110056#_0b57d561_fdb1_4442_bd4b_34e1303195d1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: ALG2
is encoded by: hsa:85365
is: Q9H553

http://identifiers.org/biomodels.db/MODEL1310110056#_0ec01b77_538e_4d67_9367_5182712d549d
type: Species
initial concentration: NaN
name: INPPL1
has only substance units: false
constant: false
is encoded by: hsa:3636
boundary condition: true
initial amount: NaN
is: O15357
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_7c2a0880_9723_4ff1_ab86_329b669f51ad
boundary condition: true
is encoded by: hsa:226
type: Species
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: ALDOA
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_31277f3c_01bd_4605_ad80_72bd7fc0bba7
type: Species
is: Q9Y3Y1
is encoded by: hsa:65010
initial concentration: NaN
has only substance units: false
name: SLC26A6
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252

metaR APOC LYS BTNPm
kinetic law: MODEL1310110056#
is: SBO:0000176
fast: false
name: proteolysis of apoC-Lys-btn, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reversible: false
product: MODEL1310110056#
is described by: ECO:0000000
reactant: MODEL1310110056#

metaR FAOXC226
reactant: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
product: MODEL1310110056#
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reversible: false
is described by: ECO:0000000
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_83e3ae2c_a5e6_44b8_85a9_38fbb4a27028
name: HK1
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:3098
is: P78542
has only substance units: false

metaR r1567
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110056#
type: Reaction
reversible: true
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110056#_69d319c1_96db_4ef9_a155_79debf6b86ff
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: PIGF
constant: false
type: Species
has only substance units: false
is encoded by: hsa:5281
is: Q07326

metaR CHAT
reactant: MODEL1310110056#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
name: Choline O-acetyltransferase
fast: false
modifier: MODEL1310110056#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110056#
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.3.1.6

metaM 3docopencoa x
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
type: Species
constant: false
name: 3,7,10,13,16-docosapentenoylcoa
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM dhap x
boundary condition: false
is: C00111
is: SBO:0000247
is: CHEBI:57642
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01473
constant: false
name: Dihydroxyacetone phosphate
is: http://identifiers.org/pubchem.compound/3411
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_bbef0eb5_85c9_4938_bd45_5acec461a1c1
constant: false
name: SULT1A1
is encoded by: hsa:6817
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_e0a57e20_f90f_4aff_9336_9f74fe8b046e
name: CDA
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
is: P32320
initial amount: NaN
is encoded by: hsa:978
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_f538da57_7aa8_4c4b_baeb_549495739036
initial concentration: NaN
name: SLC35C1
type: Species
is encoded by: hsa:55343
is: B3KQH0
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252

metaM dece3coa m
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
is: SBO:0000247
name: 3-decenoylcoa
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false

metaM m6masnB2 g
initial concentration: 1.0
constant: false
is: CHEBI:30825
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C58H97N2O45X CHARGE: 0
has only substance units: false
is: HMDB00573

metaR RPE
name: ribulose 5-phosphate 3-epimerase
fast: false
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
product: MODEL1310110056#
modifier: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.1.3.1
type: Reaction
kinetic law: MODEL1310110056#
is described by: ECO:0000000
reversible: true

metaR PI34P5K
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.68
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
modifier: MODEL1310110056#
reversible: false
product: MODEL1310110056#
fast: false
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#

metaR r1568
product: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110056#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#

metaR GALASE20ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110056#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
modifier: MODEL1310110056#
product: MODEL1310110056#
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR GGH 6DHFe
is described by: ECO:0000000
reactant: MODEL1310110056#
name: Gamma-glutamyl hydrolase (6DHF), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
reversible: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_5d3401b8_9899_413a_953e_4dcdb1b6c0f0
is: SBO:0000252
is encoded by: hsa:1644
has only substance units: false
type: Species
initial concentration: NaN
constant: false
name: DDC
boundary condition: true
initial amount: NaN
is: Q53Y41

http://identifiers.org/biomodels.db/MODEL1310110056#_e95e9e27_768c_480c_bc8e_debe8a4425ab
constant: false
initial concentration: NaN
is encoded by: hsa:4709
initial amount: NaN
type: Species
name: NDUFB3
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q6IB80

metaM urcan c
constant: false
is: CHEBI:17771
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00301
is: C00785
name: Urocanate
boundary condition: false
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
initial concentration: 1.0

metaR B MANNASEly
reversible: false
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.25
is: SBO:0000176
reactant: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110056#
fast: false
name: beta-mannosidase, lysosomal
modifier: MODEL1310110056#

metaR EX ptth LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ptth
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_0e44b3bd_35e0_4f74_8534_012e03483939
is encoded by: hsa:3295
initial amount: NaN
initial concentration: NaN
is: E9PB82
boundary condition: true
name: HSD17B4
is: SBO:0000252
constant: false
type: Species
has only substance units: false

metaR TSTSTERONEt
type: Reaction
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110056#
name: Testosterone transport

http://identifiers.org/biomodels.db/MODEL1310110056#_8be793e1_cc18_4e68_8ca8_9ffe53387d66
is: H0YMZ7
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:5151
name: PDE8A

metaM ksii core4 pre3 g
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: C00130
is: SBO:0000247
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 3
is: CHEBI:58053
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C55H89N5O38X CHARGE: -1

metaM eitetcoa m
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
name: 5,8,11,14-eicosatetraenoylcoa
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/24892790

http://identifiers.org/biomodels.db/MODEL1310110056#_fffbebeb_7f46_47ca_8e0f_703e326ca339
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR FAOXC14C12m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)m
type: Reaction

metaM dump c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB01409
initial amount: NaN
is: CHEBI:246422
is: C00365
name: dUMP
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
type: Species

metaR r0390
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
type: Reaction
is: SBO:0000176
product: MODEL1310110056#
is described by: ECO:0000000
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
reversible: true

metaR r1565
reversible: true
reactant: MODEL1310110056#
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110056#
is: SBO:0000185
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_57bf8627_0361_40f0_8cae_e0187b9675e2
is: SBO:0000252
initial amount: NaN
is: Q9NQU1
is encoded by: hsa:65010
boundary condition: true
has only substance units: false
type: Species
constant: false
initial concentration: NaN
name: SLC26A6

http://identifiers.org/biomodels.db/MODEL1310110056#_7e275361_5241_4293_9a2c_2e68413c99a0
boundary condition: true
initial concentration: NaN
name: AFMID
initial amount: NaN
is: Q63HM1
type: Species
is encoded by: hsa:125061
has only substance units: false
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_ae9cdfab_a3e6_4c02_b02f_8f81779cae16
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:10455
constant: false
is: O75521
name: ECI2
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR RE3272N
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
reversible: true
product: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110056#
name: RE3272
is: SBO:0000176
type: Reaction

metaM 44mctr r
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
initial amount: NaN
type: Species
initial concentration: 1.0
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
is: HMDB01023
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:17813

metaR ACGAMPM
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110056#
is described by: ECO:0000269
modifier: MODEL1310110056#
reversible: true
product: MODEL1310110056#
kinetic law: MODEL1310110056#
name: phosphoacetylglucosamine mutase
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
is version of: http://identifiers.org/ec-code/5.4.2.3

metaR SBTR
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
reactant: MODEL1310110056#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.2
name: D-sorbitol reductase
product: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.21
is described by: ECO:0000269
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false

metaR MCCCrm
name: methylcrotonoyl-CoA carboxylase, mitochondrial
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
reversible: true
is described by: ECO:0000269
product: MODEL1310110056#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/6.4.1.4
type: Reaction
modifier: MODEL1310110056#

metaR r1566
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#

metaM dcyt c
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
type: Species
name: Deoxycytidine
is: C00881
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00014
is: SBO:0000247
constant: false
is: CHEBI:15698
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110056#_10d79d4b_c667_4915_86aa_afb603480616
has only substance units: false
is: P04075
is: SBO:0000252
is encoded by: hsa:226
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
name: ALDOA

metaR G14T17g
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110056#_57a98899_8f98_482c_8bb5_bfc8ac6ca2c4
is encoded by: hsa:80025
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
name: PANK2
initial amount: NaN
has only substance units: false

metaM c8crn e
is: SBO:0000247
has only substance units: false
is: HMDB00791
constant: false
notes: FORMULA: C15H29NO4 CHARGE: 0
initial concentration: 1.0
type: Species
name: octanoyl carnitine
is: C02838
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_d3206b64_e2a8_4952_8284_8bd583ad5cc9
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
name: SULT1A2
constant: false
is encoded by: hsa:6799
is: SBO:0000252
is: P50226

metaM sphgn c
constant: false
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
is: CHEBI:57817
name: sphinganine(1+)
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00269
has only substance units: false
is: SBO:0000247

metaR DNDPt11m
type: Reaction
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dADP transport via dGDP antiport
is: SBO:0000185
reactant: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000269
fast: false
reversible: false
modifier: MODEL1310110056#

metaR N2M2NMASNtly
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110056#
reversible: false
reactant: MODEL1310110056#
name: n2m2nmasn transport, extracellular to lysosome
kinetic law: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR r0186
kinetic law: MODEL1310110056#
reversible: false
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
fast: false
reactant: MODEL1310110056#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110056#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_85e61db9_d825_4de8_9f06_e87e6a850cf7
name: GPD1
constant: false
initial amount: NaN
type: Species
is: F8W1L5
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2819
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_e40dd50d_c278_4ca0_bea9_80c327044edf
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:341947
has only substance units: false
boundary condition: true
name: COX8C
type: Species
constant: false
initial amount: NaN
is: Q7Z4L0

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaM n2m2nmn l
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C50H84N4O36 CHARGE: 0
is: HMDB00742
is: SBO:0000247
constant: false
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
has only substance units: false
is: CHEBI:17588
initial concentration: 1.0

metaR CO2tp
product: MODEL1310110056#
reversible: true
kinetic law: MODEL1310110056#
is: SBO:0000185
name: CO2 peroxisomal transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110056#
is described by: ECO:0000000
fast: false

metaM strdnccoa c
is: http://identifiers.org/pubchem.compound/47205473
type: Species
initial concentration: 1.0
is: HMDB06519
name: stearidonyl coenzyme A
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
has only substance units: false
is: C16163
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false

metaM tddedicoa m
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
type: Species
name: trans3,6dodecadienoylcoa
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/5280771
initial amount: NaN

metaR MANter
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110056#
name: mannose efflux from endoplasmic reticulum
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110056#
product: MODEL1310110056#
reversible: false

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_98f96661_5b26_413e_b4a4_1f538867efba
is: SBO:0000252
name: ALDH1B1
initial amount: NaN
boundary condition: true
type: Species
is: P30837
constant: false
has only substance units: false
is encoded by: hsa:219
initial concentration: NaN

metaR r0399
reversible: true
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.2
is described by: ECO:0000000
modifier: MODEL1310110056#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110056#_7e881212_e1f1_4cf9_8f52_fdab4a1229b0
is encoded by: hsa:AW299740
constant: false
boundary condition: true
initial concentration: NaN
name: _AW299740_1_m
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species

metaR r1177
reactant: MODEL1310110056#
is: SBO:0000176
type: Reaction
product: MODEL1310110056#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
kinetic law: MODEL1310110056#
name: EC:3.1.1.13
reversible: false

metaM pail hs c
type: Species
name: 1-phosphatidyl-1D-myo-inositol(1-)
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57880
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_259ba7ce_6795_4237_a123_66d2cef89940
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: PIGP
is encoded by: hsa:51227
type: Species
constant: false

metaM HC02175 c
constant: false
boundary condition: false
is: CHEBI:27689
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
is: SBO:0000247
name: caprate
initial concentration: 1.0

metaM CE4795 x
type: Species
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,18-21,28-30,34-36,40,51-52H,4-7,10,13,16-17,22-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,19-18-,21-20+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4795
constant: false
initial amount: NaN
name: 2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:57923

http://identifiers.org/biomodels.db/MODEL1310110056#_683fd030_a7a9_462e_bf12_e0d8d98ebd5d
type: Species
name: NDUFA1
is encoded by: hsa:4694
initial amount: NaN
constant: false
boundary condition: true
is: Q6IBB5
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR r1459
product: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
name: Transport reaction
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false

metaM orn c
is: CHEBI:0
name: Ornithine
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: C01602
constant: false
initial amount: NaN
is: HMDB00214
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false

metaR FACOAL150
kinetic law: MODEL1310110056#
reversible: true
name: fatty-acid--CoA ligase
product: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
is: SBO:0000176
fast: false
is described by: ECO:0000000

metaM ach e
is: SBO:0000247
initial amount: NaN
name: acetylcholine
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: CHEBI:15355
is: HMDB00895
type: Species

metaR 3HBCOAHLm
product: MODEL1310110056#
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
is described by: ECO:0000000
kinetic law: MODEL1310110056#
reversible: false
fast: false
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_3e093c44_200d_488d_b4c1_bf57d31b1e53
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:377841
name: ENTPD8
constant: false
initial concentration: NaN
has only substance units: false
is: Q5MY95
initial amount: NaN

metaM c8crn c
constant: false
initial amount: NaN
name: octanoyl carnitine
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: C02838
notes: FORMULA: C15H29NO4 CHARGE: 0
is: SBO:0000247
is: HMDB00791

metaR EX c51crn
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

metaR r0281
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
kinetic law: MODEL1310110056#
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
is: SBO:0000176
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.3.1.6

metaM glu5p m
boundary condition: false
is: HMDB01228
initial amount: NaN
is: CHEBI:58274
constant: false
has only substance units: false
name: L-Glutamate 5-phosphate
notes: FORMULA: C5H8NO7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01092 EHMN_ABBREVIATION: C03287
is: SBO:0000247
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110056#_9223c630_d89f_472f_9977_6b212da57586
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:AI971036
name: _AI971036_1_x
boundary condition: true

metaR VALTA
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
kinetic law: MODEL1310110056#
product: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110056#
type: Reaction
name: valine transaminase
reversible: true
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:

metaR HIVCACBP
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyisovalerylcoa from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_e8cbbf86_dbec_4404_95f7_fa68746b1461
has only substance units: false
is: SBO:0000252
name: _AI435857_1_x
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AI435857
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_9278622b_bcf4_46d9_8cdb_6c2f37d512d7
initial amount: NaN
is encoded by: hsa:1716
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is: E5KSL6
constant: false
name: DGUOK
is: SBO:0000252

metaR C161OHc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecenoylcarnitine
type: Reaction

metaM ksi deg21 l
is: HMDB00143
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:12936
is: SBO:0000247
boundary condition: false
name: keratan sulfate I, degradation product 21
initial amount: NaN
type: Species
notes: FORMULA: C132H213N9O114S6 CHARGE: -6

metaR O2Stm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
product: MODEL1310110056#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110056#
is: SBO:0000185
fast: false
type: Reaction
name: superoxide anion transport via diffusion (mitochondria)
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_7c77eb1f_1084_48e3_8428_0f1098ffc731
initial concentration: NaN
boundary condition: true
name: _BE966236_1_c
initial amount: NaN
constant: false
is encoded by: hsa:BE966236
type: Species
has only substance units: false
is: SBO:0000252

metaR VALTAm
type: Reaction
fast: false
product: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.42
is described by: ECO:0000269
name: valine transaminase, mitochondiral
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
reversible: true
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD

metaM btamp c
constant: false
boundary condition: false
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
type: Species
is: SBO:0000247
name: Biotinyl-5'-AMP
has only substance units: false
initial amount: NaN
is: HMDB04220
is: CHEBI:3110
initial concentration: 1.0

metaR S6TASE2ly
is: SBO:0000176
fast: false
product: MODEL1310110056#
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110056#
reversible: true
kinetic law: MODEL1310110056#
type: Reaction
is described by: ECO:0000000

metaM cholcoaone x
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
is: HMDB06891
boundary condition: false
constant: false
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
type: Species
is: CHEBI:58507
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR EX c4crn
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for butyryl carnitine
type: Reaction

metaM orn e
is: C01602
has only substance units: false
constant: false
is: CHEBI:0
initial amount: NaN
name: Ornithine
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: HMDB00214
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false

metaM ach c
type: Species
boundary condition: false
is: HMDB00895
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: CHEBI:15355
initial concentration: 1.0
name: acetylcholine
constant: false

metaR DOPAt4 2 r
name: Dopamine reversible transport in via sodium symport (1:2)
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110056#
reversible: true
is: SBO:0000185
product: MODEL1310110056#
modifier: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_ac757c36_6796_4727_b65b_dc532b6381b9
is encoded by: hsa:10935
initial concentration: NaN
constant: false
is: E9PH29
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
name: PRDX3
is: SBO:0000252

metaR AMETt2m
reactant: MODEL1310110056#
is described by: ECO:0000269
modifier: MODEL1310110056#
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
reversible: true
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
type: Reaction
fast: false
kinetic law: MODEL1310110056#
is: SBO:0000185
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_5a51df2e_8583_4b17_83a9_011cd7ee3cd1
boundary condition: true
is: P00325
initial amount: NaN
name: ADH1B
type: Species
constant: false
is encoded by: hsa:125
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR r0283
fast: false
name: L-Histidine:beta-alanine ligase (AMP-forming) Alanine and aspartate metabolism / Histidine metabolism / beta-Alanine metabolism EC:6.3.2.11
kinetic law: MODEL1310110056#
product: MODEL1310110056#
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (AA676725.1) or (196951.1) or (2584.1) or (2585.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 6.3.2.11 Confidence Level: 0 AUTHORS: PMID:448355,PMID:487087 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.6
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.157
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110056#

metaR FAOXC12DCx
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanedioyl carnitine
type: Reaction

metaM gdp m
initial amount: NaN
name: GDP
constant: false
is: HMDB01201
type: Species
is: C00035
boundary condition: false
is: SBO:0000247
is: CHEBI:58189
initial concentration: 1.0
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
has only substance units: false

metaM gacpail hs r
is: CHEBI:61548
is: HMDB01401
name: glucosaminyl-acylphosphatidylinositol
initial concentration: 1.0
has only substance units: false
is: C00092
initial amount: NaN
type: Species
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_126583d5_51a7_4d05_8507_4377faf5e9b3
has only substance units: false
is encoded by: hsa:10559
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: P78382
is: SBO:0000252
name: SLC35A1

metaR TMNDNCt
kinetic law: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110056#
product: MODEL1310110056#
name: fatty acid transport via diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_5e15d02b_3ee9_4985_8265_cfc2bf4852f9
has only substance units: false
initial concentration: NaN
is: P50224
is encoded by: hsa:6818
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: SULT1A3

metaR UMPK7n
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
name: UMP kinase (dGTP),nuclear
modifier: MODEL1310110056#
product: MODEL1310110056#
reversible: true
fast: false
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110056#

metaM ksi deg32 l
initial amount: NaN
is: HMDB00143
type: Species
name: keratan sulfate I, degradation product 32
boundary condition: false
is: SBO:0000247
is: CHEBI:12936
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
constant: false
initial concentration: 1.0
has only substance units: false

metaR PCHOLPg hs
name: choline phosphatase
is described by: ECO:0000269
product: MODEL1310110056#
fast: false
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.4

metaM CE5161 r
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:57923
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161
boundary condition: false

metaR r0830
fast: false
kinetic law: MODEL1310110056#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.16
modifier: MODEL1310110056#
is: SBO:0000185
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110056#
is described by: ECO:0000000

metaR r0181
type: Reaction
is: SBO:0000176
modifier: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110056#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110056#
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110056#
fast: false

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_b6833bfe_5002_45a6_82e6_d9ac5f414b59
is: SBO:0000252
type: Species
has only substance units: false
constant: false
name: ACAA2
is encoded by: hsa:10449
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: P42765

http://identifiers.org/biomodels.db/MODEL1310110056#_87e6471c_eadf_4979_8396_83787707a6e8
initial concentration: NaN
type: Species
boundary condition: true
is: O94777
is: SBO:0000252
is encoded by: hsa:8818
has only substance units: false
name: DPM2
initial amount: NaN
constant: false

metaR CO2tm
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
reversible: true
kinetic law: MODEL1310110056#
name: CO2 transport (diffusion), mitochondrial
type: Reaction
reactant: MODEL1310110056#
is described by: ECO:0000000
product: MODEL1310110056#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_c05bd82d_14c9_4c2f_93a9_449b57896d0e
is encoded by: hsa:3628
name: INPP1
is: SBO:0000252
is: P49441
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false

metaM CE2418 m
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:28387
is: SBO:0000247
boundary condition: false
is: HMDB11123
type: Species
initial amount: NaN

metaM decdp c
notes: FORMULA: C50H81O7P2 CHARGE: -3 INCHI: InChI=1/C50H90O7P2/c1-41(2)21-31-53-58(51,54-32-22-42(3)4)57-59(52,35-25-45(9)10,36-26-46(11)12,37-27-47(13)14,38-28-48(15)16,39-29-49(17)18,40-30-50(19)20,55-33-23-43(5)6)56-34-24-44(7)8/h21-30H,31-40H2,1-20H3
has only substance units: false
type: Species
is: HMDB06288
name: all trans Decaprenyl diphosphate
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false

metaR RE1810M
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
reactant: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
name: RE1810
kinetic law: MODEL1310110056#
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110056#

metaM mev R c
type: Species
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
is: HMDB00227
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: (R)-mevalonate
initial amount: NaN
is: CHEBI:36464
constant: false

metaR PGISr
name: Prostaglandin I2 synthase
is: SBO:0000176
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ
modifier: MODEL1310110056#
product: MODEL1310110056#
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/5.3.99.4
fast: false
type: Reaction
is described by: ECO:0000134
reversible: true

metaM dece3coa x
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
name: 3-decenoylcoa
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM HC02175 e
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27689
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
name: caprate
constant: false
type: Species

metaM ksi pre21 g
is: HMDB00175
is: CHEBI:58053
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
is: C00130
constant: false
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 21
type: Species

metaR FADtx
is described by: ECO:0000000
name: FAD transporter, peroxisomal
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
product: MODEL1310110056#
reversible: true
fast: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_cdc01ce4_8218_4a3d_afd9_148bae39a49f
is encoded by: hsa:4598
is: B2RDU6
constant: false
name: MVK
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_eee96bbb_fdb1_4492_b2eb_44c863b8d1a4
is encoded by: hsa:2194
is: SBO:0000252
constant: false
is: P49327
initial concentration: NaN
name: FASN
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false

metaM sphmyln hs c
name: sphingomyelin betaine
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
is: SBO:0000247
is: CHEBI:58216
boundary condition: false
initial amount: NaN

metaM noncoa m
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C30H48N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: nonanoylcoa
is: C01942
constant: false
is: HMDB13028

metaM gdp n
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: CHEBI:58189
constant: false
type: Species
is: SBO:0000247
is: HMDB01201
name: GDP(3-)
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110056#_eaf82d16_7b1e_4b21_a4fb_96e65fef3194
constant: false
name: ACSL4
is: Q5JWV8
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2182
initial amount: NaN

metaM 4h2oglt m
initial amount: NaN
name: 4-hydroxy-2-oxoglutarate(2-)
initial concentration: 1.0
type: Species
is: HMDB02070
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
is: CHEBI:17742
is: SBO:0000247

metaM ksi pre9 g
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
constant: false
is: C00130
initial concentration: 1.0
is: SBO:0000247
type: Species
name: keratan sulfate I biosynthesis, precursor 9
is: CHEBI:58053
has only substance units: false
is: HMDB00175
initial amount: NaN
boundary condition: false

metaR FACOAL246 1
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110056#
modifier: MODEL1310110056#
fast: false
type: Reaction
name: fatty-acid--CoA ligase
is: SBO:0000176
reversible: true
reactant: MODEL1310110056#

metaR SPHK21c
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
type: Reaction
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.1.91
fast: false
reversible: false
product: MODEL1310110056#
is: SBO:0000176
kinetic law: MODEL1310110056#
name: sphingosine kinase 2
is described by: ECO:0000269
modifier: MODEL1310110056#

metaR CGLYt3 2
modifier: MODEL1310110056#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110056#
product: MODEL1310110056#
name: Cys-Gly transport in via proton symport
is described by: ECO:0000304
kinetic law: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
reversible: false

metaR OCDCEAtr
fast: false
type: Reaction
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
reversible: true
name: fatty acid transport via diffusion
is described by: ECO:0000000

metaM 2maacoa m
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
name: 2-methylacetoacetyl-CoA(4-)
is: HMDB01157
is: CHEBI:57335
initial amount: NaN
constant: false
is: SBO:0000247

metaM cs e deg1 l
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
is: CHEBI:57737
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
has only substance units: false
is: HMDB00868
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_898fd280_b19d_4537_b688_a0aa36ad58d5
has only substance units: false
name: SPHK2
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:56848
constant: false
is: Q9NRA0
boundary condition: true
initial amount: NaN

metaR r0909
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110056#
product: MODEL1310110056#
name: Transport reaction
is described by: ECO:0000000
is: SBO:0000185

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaM HC01444 e
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: Galactosylglycerol
is: CHEBI:15754
type: Species
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_46c374c5_d147_47ef_b5d7_ed0114eb0ca2
name: _BF195998_1_x
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:BF195998

metaM c4dc x
type: Species
is: HMDB02013
is: http://identifiers.org/pubchem.compound/213144
initial concentration: 1.0
is: C02862
constant: false
is: SBO:0000247
initial amount: NaN
name: succinyl carnitine
notes: FORMULA: C11H18NO6 CHARGE: -1
boundary condition: false
has only substance units: false

metaR CYTK7n
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110056#
name: cytidylate kinase (CMP,UTP),nuclear
modifier: MODEL1310110056#
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110056#

metaR MELATNOX
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.48
name: Melatonin:NADP oxidoreductase
reversible: false
is version of: http://identifiers.org/ec-code/1.14.14.1
type: Reaction
fast: false
modifier: MODEL1310110056#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1557.1) or (1543.1) or (1545.1) or (1544.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15616152 NOTES:SAB made up name

http://identifiers.org/biomodels.db/MODEL1310110056#_6212fb07_fa67_4c18_b1e8_333290037458
constant: false
is encoded by: hsa:641371
initial amount: NaN
is: E9KL42
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
name: ACOT1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_90b78caa_c837_4ca5_ad3d_4d937aed865e
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1718
name: DHCR24
type: Species
has only substance units: false
constant: false
is: Q15392
initial amount: NaN

metaR C5DCe
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of glutaryl carnitine into the extra cellular fluid
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_7566798e_522c_4207_8714_1f4496b7990b
is: SBO:0000252
is: B4DPV0
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5236
has only substance units: false
initial amount: NaN
name: PGM1
type: Species

metaM CE5132 n
is: CHEBI:57923
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
has only substance units: false
type: Species
initial amount: NaN
constant: false

metaR GPDDA1
reversible: false
type: Reaction
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.46 Confidence Level: 0 AUTHORS: NOTES:JLR
reactant: MODEL1310110056#
is: SBO:0000176
kinetic law: MODEL1310110056#
fast: false
product: MODEL1310110056#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_bfcd68d3_23e8_4516_a562_cd29c009ad00
is: SBO:0000252
is: A6NED0
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:2954
initial amount: NaN
boundary condition: true
name: GSTZ1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_c497333e_cf50_4c27_948b_fe3d34502c09
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:23556
name: PIGN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_7ca160df_0235_4f8f_991a_78ad0b838073
name: CDIPT
initial concentration: NaN
is: A8K3L7
boundary condition: true
type: Species
is encoded by: hsa:10423
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false

metaM r5p r
is: CHEBI:18189
name: alpha-D-Ribose 5-phosphate
is: HMDB00618
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species

metaM gam c
is: SBO:0000247
is: C00329
boundary condition: false
constant: false
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
type: Species
name: D-Glucosamine
is: HMDB01514
initial amount: NaN
is: CHEBI:17315
has only substance units: false
initial concentration: 1.0

metaR NACHEXA19ly
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110056#
product: MODEL1310110056#
reversible: false
kinetic law: MODEL1310110056#
fast: false
reactant: MODEL1310110056#

metaM gdp g
is: HMDB01201
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:58189
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: SBO:0000247
name: GDP(3-)
initial concentration: 1.0
has only substance units: false
type: Species

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaM hs deg3 l
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: heparan sulfate, degradation product 3
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
is: CHEBI:16126
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaR FALDH
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.1
modifier: MODEL1310110056#
is described by: ECO:0000269
reversible: true
product: MODEL1310110056#
kinetic law: MODEL1310110056#
name: formaldehyde dehydrogenase
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
fast: false

metaR EX 25hvitd3 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 25-Hydroxyvitamin D3 exchange
type: Reaction

metaR FAOXC226C205m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

metaM retinal cis 13 r
initial concentration: 1.0
boundary condition: false
is: CHEBI:45487
has only substance units: false
constant: false
name: 13-cis-retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
type: Species
is: HMDB06220
is: SBO:0000247
initial amount: NaN

metaM 3dhguln c
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
boundary condition: false
type: Species
has only substance units: false
name: 3-dehydro-L-gulonate
is: CHEBI:57655
is: SBO:0000247
is: HMDB06334
constant: false
initial amount: NaN
initial concentration: 1.0

metaR BTNDm
fast: false
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
type: Reaction
reversible: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.5.1.12
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110056#
name: biotinidase (biotin), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110056#_b040d7d4_d89e_4e48_808c_c09cace852f1
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:50487
name: PLA2G3
is: Q9NZ20
type: Species
initial amount: NaN
has only substance units: false

metaM 4aphdob c
has only substance units: false
type: Species
initial amount: NaN
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
is: HMDB00978
boundary condition: false
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58147

http://identifiers.org/biomodels.db/MODEL1310110056#_1e01d444_8dd0_4a06_8e70_950950faddcc
initial amount: NaN
has only substance units: false
is: Q9UI32
initial concentration: NaN
name: GLS2
is: SBO:0000252
is encoded by: hsa:27165
type: Species
boundary condition: true
constant: false

metaR EX gdp LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GDP exchange
type: Reaction

metaR r1998
is described by: ECO:0000000
product: MODEL1310110056#
modifier: MODEL1310110056#
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110056#

metaM arachdcoa m
type: Species
constant: false
has only substance units: false
is: HMDB06523
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: CHEBI:57368
name: arachidonoyl-CoA(4-)
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_354f00fa_e005_49a3_b6e7_87426b1a91ae
type: Species
has only substance units: false
is encoded by: hsa:1215
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
name: CMA1
is: Q4FEB3
initial concentration: NaN

metaR SMPD3g
type: Reaction
reactant: MODEL1310110056#
reversible: false
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.4.12
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
is described by: ECO:0000304
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is: SBO:0000176
fast: false

metaM fuc1p L c
constant: false
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
is: HMDB01265
type: Species
name: L-Fucose 1-phosphate
is: CHEBI:28319
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR HTDCACBP
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxytetradecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM HC02216 e
initial amount: NaN
boundary condition: false
is: CHEBI:28922
initial concentration: 1.0
name: prostaglandin-f2beta
is: SBO:0000247
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
has only substance units: false
constant: false

metaM gdp e
is: HMDB01201
constant: false
initial amount: NaN
name: GDP(3-)
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:58189
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
boundary condition: false

metaM cs b deg3 l
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 3
boundary condition: false
is: HMDB02704
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C37H55NO38S2 CHARGE: -4
type: Species
is: CHEBI:21338
constant: false
is: SBO:0000247
has only substance units: false

metaR FAOXC200180x
is: SBO:0000176
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: false
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Beta oxidation of long chain fatty acid
fast: false
is described by: ECO:0000000
reactant: MODEL1310110056#
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaR r1997
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
fast: false
reactant: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_94aae6c0_0e65_4806_82aa_cd42a5dbbc35
constant: false
boundary condition: true
has only substance units: false
name: _LOC647190_1_c
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:LOC647190
type: Species

metaM c12dccoa c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
boundary condition: false
is: HMDB00623
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: dodecanedioylcoa

metaM 5htrp c
is: CHEBI:17780
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
name: 5-hydroxy-L-tryptophan
initial concentration: 1.0
type: Species
is: HMDB00472
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_efd8506d_9bdf_4cc5_90cc_33167e83fa08
type: Species
boundary condition: true
is: Q8WXF9
constant: false
has only substance units: false
is: SBO:0000252
name: SLC2A11
is encoded by: hsa:66035
initial concentration: NaN
initial amount: NaN

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaM HC02216 c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: prostaglandin-f2beta
boundary condition: false
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
constant: false
is: CHEBI:28922
is: SBO:0000247

metaM ksi deg5 l
name: keratan sulfate I, degradation product 5
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
initial amount: NaN
is: HMDB00143
type: Species
boundary condition: false
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110056#_c5a9a4a8_fa47_4cb1_b68f_0f8dde8a0dfb
initial concentration: NaN
is encoded by: hsa:1811
name: SLC26A3
is: P40879
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN

metaR PMANM
name: phosphomannomutase
is described by: ECO:0000000
reversible: true
product: MODEL1310110056#
fast: false
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.4.2.8
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.2.2
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:

metaR DAGK hs
name: Diacylglycerol phosphate kinase (homo sapiens)
type: Reaction
reversible: true
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.107
is: SBO:0000176
reactant: MODEL1310110056#
product: MODEL1310110056#

metaR S6T15g
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
kinetic law: MODEL1310110056#
fast: false
product: MODEL1310110056#
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.21
is: SBO:0000176
reactant: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.17
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaR ACGAMK
type: Reaction
fast: false
name: N-acetylglucosamine kinase
reactant: MODEL1310110056#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.1.59
product: MODEL1310110056#
reversible: false
modifier: MODEL1310110056#

metaM accoa c
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: CHEBI:57288
name: Acetyl-CoA
initial amount: NaN
is: HMDB01206
is: SBO:0000247
is: C00024
boundary condition: false
constant: false

metaR FATP3t
fast: false
product: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is: SBO:0000185
kinetic law: MODEL1310110056#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110056#
name: fatty acid electroneutral transport
type: Reaction

metaM l2n2m2mn l
initial amount: NaN
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
constant: false
boundary condition: false
type: Species
is: CHEBI:12936
is: HMDB00143
notes: FORMULA: C54H91N3O41 CHARGE: 0
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR TETDEC2CRNe
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of tetradecadienoyl carnitine into extra cellular space
type: Reaction

metaR PROt2r
kinetic law: MODEL1310110056#
is described by: ECO:0000304
fast: false
modifier: MODEL1310110056#
is: SBO:0000185
name: L-proline reversible transport via proton symport
reversible: true
type: Reaction
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
product: MODEL1310110056#

metaM tetpent3coa c
has only substance units: false
type: Species
name: tetracosapentaenoyl coenzyme A, n-3
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1
is: C16167

metaM 4izp c
is: SBO:0000247
boundary condition: false
is: CHEBI:57255
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
is: HMDB01014
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: 4-Imidazolone-5-propanoate

metaM 7dhchsterol r
boundary condition: false
name: cholesta-5,7-dien-3beta-ol
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
is: SBO:0000247
initial amount: NaN
is: HMDB00032
is: CHEBI:17759
constant: false
type: Species

metaR ACNAMtn
is described by: ECO:0000000
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110056#
reversible: false
type: Reaction
name: N-acetylneuraminate nuclear import
fast: false
is: SBO:0000185
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_2afe58fb_adb7_4021_a8fb_1b0982d1ac7d
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: SLC5A2
is encoded by: hsa:6524
is: P31639
initial concentration: NaN
has only substance units: false
constant: false

metaR LNLCCPT2
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
name: carnitine transferase
is: SBO:0000176
product: MODEL1310110056#
fast: false
is described by: ECO:0000000
reversible: false

metaM gam e
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: C00329
is: HMDB01514
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
initial amount: NaN
boundary condition: false
is: CHEBI:17315
name: D-Glucosamine
has only substance units: false

metaR NDP8
is version of: http://identifiers.org/ec-code/2.7.4.9
reversible: false
type: Reaction
product: MODEL1310110056#
modifier: MODEL1310110056#
name: nucleoside-diphosphatase (dUDP)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_16fdbbce_d5f6_45c3_b97e_f89f6e55f6d8
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9152
name: SLC6A5
has only substance units: false
is: Q9Y345
type: Species
boundary condition: true
initial concentration: NaN

metaM CE4790 m
constant: false
has only substance units: false
boundary condition: false
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57923

metaR KHte
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: KHte
kinetic law: MODEL1310110056#
is: SBO:0000185
reactant: MODEL1310110056#
type: Reaction
is described by: ECO:0000134
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110056#_f655d716_b505_4669_8899_e34442f68289
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI440329
name: _AI440329_1_r
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR RE2626M
is: SBO:0000176
modifier: MODEL1310110056#
reversible: true
is described by: ECO:0000000
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110056#
fast: false
type: Reaction
name: RE2626
reactant: MODEL1310110056#

metaR BAAT1x
modifier: MODEL1310110056#
is: SBO:0000176
fast: false
is described by: ECO:0000269
product: MODEL1310110056#
name: bile acid Coenzyme A: amino acid N-acyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
kinetic law: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
reactant: MODEL1310110056#

metaR ARACHt
type: Reaction
is described by: ECO:0000000
product: MODEL1310110056#
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110056#
name: fatty acid transport via diffusion

metaR CLOXAtex2
kinetic law: MODEL1310110056#
fast: false
reactant: MODEL1310110056#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is: SBO:0000185
reversible: false
modifier: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
name: chloride transport via oxalate countertransport (2:1)

metaM leuktrE4 e
constant: false
type: Species
is: HMDB02200
boundary condition: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:57462
initial amount: NaN
name: leukotriene E4(1-)

metaR r1570
fast: false
type: Reaction
product: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM hom L e
initial amount: NaN
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: SBO:0000247
name: L-homoserine
is: HMDB00719
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:15699

metaM tmndnc e
is: http://identifiers.org/pubchem.compound/446284
constant: false
is: SBO:0000247
is: HMDB01999
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial concentration: 1.0
type: Species
name: timnodonic acid C20:5, n-3

http://identifiers.org/biomodels.db/MODEL1310110056#_13d05a28_d8d9_42f9_b095_4387a3ade289
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:8527
name: DGKD
type: Species
initial concentration: NaN
constant: false
is: Q16760

metaR DGNSKm
modifier: MODEL1310110056#
type: Reaction
product: MODEL1310110056#
is: SBO:0000176
fast: false
reactant: MODEL1310110056#
name: deoxyguanosine kinase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1716.5) or (1716.1) or (1716.4) or (1716.2) or (1716.3) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:8692979 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.113
kinetic law: MODEL1310110056#

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_ad7d7e98_7227_40ec_b517_e48dca9b6074
name: NDUFV2
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: P19404
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4729
type: Species

metaR METAT
modifier: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
reversible: false
kinetic law: MODEL1310110056#
is described by: ECO:0000269
fast: false
is: SBO:0000176
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (4143.1) or (27430.2 and 4144.1) or (27430.1 and 4144.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.5.1.6
name: methionine adenosyltransferase

http://identifiers.org/biomodels.db/MODEL1310110056#_f6c6e676_3aab_4db8_a631_d11a87e5b720
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:293
type: Species
is: SBO:0000252
name: SLC25A6
is: Q6I9V5

metaM vacc e
initial amount: NaN
is: CHEBI:30828
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
type: Species
boundary condition: false
name: trans-vaccenate
is: SBO:0000247

metaR EX hpdca LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptadecanoate exchange
type: Reaction

metaR ADPACTD
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport into cytosol (diffusion)
type: Reaction

metaR CREATt4 2 r
is: SBO:0000185
name: Creatine transport (sodium symport) (2:1)
reversible: true
reactant: MODEL1310110056#
type: Reaction
fast: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110056#
is described by: ECO:0000269

metaR RE2649C
modifier: MODEL1310110056#
name: RE2649
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.2
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
reversible: true
type: Reaction

metaM retfa e
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
initial concentration: 1.0
name: fatty acid retinol
type: Species
is: HMDB00508
is: CHEBI:15963
boundary condition: false
is: SBO:0000247

metaR THRSERNaEx
modifier: MODEL1310110056#
is: SBO:0000185
name: L-serine/L-threonine Na-dependent exchange (Thr-L in)
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
type: Reaction
is described by: ECO:0000269
reversible: false
product: MODEL1310110056#
reactant: MODEL1310110056#

metaR BTNDe
fast: false
modifier: MODEL1310110056#
type: Reaction
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110056#
is: SBO:0000176
name: biotinidase (biotin), extracellular
product: MODEL1310110056#
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.5.1.12
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT

metaM leuktrE4 c
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
boundary condition: false
has only substance units: false
is: HMDB02200
initial concentration: 1.0
name: leukotriene E4(1-)
is: CHEBI:57462
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_785dae7c_a5d6_45c3_a2b7_5e306deee17b
has only substance units: false
is: SBO:0000252
is: P10696
constant: false
name: ALPPL2
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:251
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_dac64959_7601_453d_9b07_8bc189827176
constant: false
name: ALDH3B1
is: P43353
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:221
boundary condition: true
is: SBO:0000252
type: Species

metaR UAG2EMAi
name: UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
fast: false
product: MODEL1310110056#
reversible: false
is version of: http://identifiers.org/ec-code/5.1.3.14
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:
reactant: MODEL1310110056#
type: Reaction
modifier: MODEL1310110056#
is described by: ECO:0000269
is: SBO:0000176

metaM HC01405 m
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
name: (S)-Hydroxyoctanoyl-CoA
is: CHEBI:28632
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
constant: false
initial amount: NaN
boundary condition: false

metaR FAOXC185C164m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

metaM tmndnc c
is: http://identifiers.org/pubchem.compound/446284
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB01999
boundary condition: false
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial amount: NaN
name: timnodonic acid C20:5, n-3
initial concentration: 1.0
type: Species

metaM hom L c
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: CHEBI:15699
is: HMDB00719
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
name: L-homoserine

http://identifiers.org/biomodels.db/MODEL1310110056#_2c7cf927_629d_49cf_a3fa_9fd243187c09
constant: false
name: ST3GAL1
initial concentration: NaN
is encoded by: hsa:6482
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR AKGMALtm
product: MODEL1310110056#
is described by: ECO:0000269
reactant: MODEL1310110056#
name: alpha-ketoglutarate/malate transporter
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110056#
reversible: true
modifier: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_c23e0686_87fd_4a3e_9f35_9efe38674328
is encoded by: hsa:427
boundary condition: true
has only substance units: false
constant: false
name: ASAH1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q96AS2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_7251ef63_78d2_4778_bdd9_da322824efbf
is: SBO:0000252
is: F6VPY9
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
name: SLC8A1
type: Species
initial amount: NaN
is encoded by: hsa:6546

metaR AKR1D2
is version of: http://identifiers.org/ec-code/1.3.1.3
is described by: ECO:0000269
reversible: false
fast: false
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
product: MODEL1310110056#
modifier: MODEL1310110056#
is: SBO:0000176
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
type: Reaction

metaR ACGALK2
reactant: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110056#
type: Reaction
name: N-acetylgalactosamine kinase (ITP)
product: MODEL1310110056#
fast: false

metaR r0497
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.2
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reversible: true
reactant: MODEL1310110056#

metaM 3ivcoa c
is: C05998
is: http://identifiers.org/pubchem.compound/11966188
is: HMDB06870
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
initial concentration: 1.0
name: 3-hydroxyisovalerylcoa
boundary condition: false
type: Species

metaR r1571
type: Reaction
kinetic law: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110056#
reversible: true
product: MODEL1310110056#

metaR ALCD21 D
fast: false
is: SBO:0000176
is described by: ECO:0000304
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.1
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
name: alcohol dehydrogenase (D-1,2-propanediol)
product: MODEL1310110056#
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.1.99.24
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction

metaR r1996
reversible: false
modifier: MODEL1310110056#
is described by: ECO:0000000
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110056#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

http://identifiers.org/biomodels.db/MODEL1310110056#_edb9fb43_8ca1_4be7_84ec_f6dbaa8a82da
constant: false
is encoded by: hsa:6240
is: SBO:0000297
is encoded by: hsa:6241
has part: P31350
initial concentration: NaN
type: Species
boundary condition: true
has part: P23921
name: RRM1:RRM2
has only substance units: false
initial amount: NaN

metaM c8dc x
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00893
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C15H26NO6 CHARGE: -1
boundary condition: false
name: suberyl carnitine

metaR C121CPT1
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecenoylcarnitine
type: Reaction

metaR GGH 10FTHF6GLUe
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110056#
is: SBO:0000176
reactant: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
type: Reaction
reversible: false
is described by: ECO:0000000

metaR r1574
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction

metaR MALSO3tm
is described by: ECO:0000269
reactant: MODEL1310110056#
name: Malate:sulfite antiport, mitochondrial
reversible: true
modifier: MODEL1310110056#
fast: false
kinetic law: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_eeba6330_9f62_4ee1_88f3_b6758f4a2062
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
name: PLCZ1
is: Q86YW0
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:89869

metaR r0494
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
type: Reaction
fast: false
product: MODEL1310110056#
is: SBO:0000176
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is described by: ECO:0000000
reversible: true

metaR FAOXC141C121x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C14:1-->C12:1)x
type: Reaction

metaR DOLPGT1 Uer
product: MODEL1310110056#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.267
reversible: false
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10359825 NOTES:EC 2.4.1.- NCD
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_b1397d47_6f90_4e04_b9ab_8b0d88f60936
initial amount: NaN
is: SBO:0000297
has only substance units: false
boundary condition: true
is encoded by: hsa:3032
type: Species
initial concentration: NaN
has part: P55084
is encoded by: hsa:3030
name: HADHA:HADHB
constant: false
has part: E9KL44

metaR EX 3ttetddcoacrn
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy trans5,8tetradecadienoyl carnitine
type: Reaction

metaM hgentis c
has only substance units: false
boundary condition: false
name: homogentisate
constant: false
is: HMDB00130
is: CHEBI:16169
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544

http://identifiers.org/biomodels.db/MODEL1310110056#_938428f5_bff8_496d_bcdc_be3f6758e84d
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: Q53TV9
is encoded by: hsa:6120
is: SBO:0000252
name: RPE

metaM CE2420 m
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
has only substance units: false
initial concentration: 1.0
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB11123
is: CHEBI:28387

http://identifiers.org/biomodels.db/MODEL1310110056#_2193f46b_6d95_4603_b651_431e38bea590
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
name: GMPPA
is encoded by: hsa:29926
has only substance units: false

metaR r1573
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110056#
reversible: true
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM gdp c
has only substance units: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
boundary condition: false
is: C00035
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB01201
name: GDP
constant: false
initial amount: NaN
is: CHEBI:58189

http://identifiers.org/biomodels.db/MODEL1310110056#_604cf1a8_8a34_4870_a01f_6c57266f2c13
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: SLC23A2
type: Species
is encoded by: hsa:9962

metaM xyl D c
is: SBO:0000247
name: aldehydo-D-xylose
initial amount: NaN
boundary condition: false
is: CHEBI:15936
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
type: Species
constant: false
initial concentration: 1.0
has only substance units: false

metaM od2coa m
has only substance units: false
constant: false
is: CHEBI:50570
boundary condition: false
type: Species
name: trans-Octadec-2-enoyl-CoA
is: SBO:0000247
is: HMDB06529
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h18-19,26-28,32-34,38,49-50H,4-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b19-18+/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE2244

metaM m4mpdol U c
boundary condition: false
is: CHEBI:37633
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
constant: false
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_c2d97245_b0c2_4801_acdf_e1665472c61d
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaM acgal c
name: N-acetyl-D-galactosamine
is: CHEBI:28037
is: HMDB00212
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_089e313e_2ef4_4830_8d0f_fd50d4d32513
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5298
constant: false
name: PI4KB
has only substance units: false
initial concentration: NaN
type: Species
is: Q9UBF8
initial amount: NaN

metaR r2439
reversible: false
fast: false
reactant: MODEL1310110056#
product: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12759755 NOTES:
is described by: ECO:0000000
type: Reaction
name: Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP), TCDB:2.A.53.2.2
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110056#_61fb478b_f679_4526_8a19_4caddfff1875
is encoded by: hsa:4967
constant: false
is: B4E3E9
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: OGDH
has only substance units: false
type: Species
boundary condition: true

metaR r1576
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
product: MODEL1310110056#

metaR r1994
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
modifier: MODEL1310110056#
reversible: false
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
product: MODEL1310110056#
type: Reaction

metaR OCCOAtm
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
is: SBO:0000185
product: MODEL1310110056#
name: Octanoyl-CoA transport, diffusion
kinetic law: MODEL1310110056#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110056#_94c895bb_0fcf_43dc_b296_f21f2accfe10
constant: false
is encoded by: hsa:259230
is: D3DWC4
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
name: SGMS1

http://identifiers.org/biomodels.db/MODEL1310110056#_73947db9_493d_47c6_99ce_bac5bf205229
boundary condition: true
has only substance units: false
name: SLC16A3
is: O15427
is encoded by: hsa:9123
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

metaR TETPENT3COAtx
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
reactant: MODEL1310110056#
product: MODEL1310110056#
name: fatty acid intracellular transport
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110056#
is described by: ECO:0000000

metaR ACACT5p
is version of: http://identifiers.org/ec-code/2.3.1.16
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
reactant: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000269
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
is: SBO:0000176

metaR r1575
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110056#
reversible: true
kinetic law: MODEL1310110056#
is described by: ECO:0000000
product: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110056#_5ea04ee6_9e83_41e1_bbad_91330e3c5b30
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: PANK1
has only substance units: false
is: SBO:0000252
type: Species
is: Q8TE04
is encoded by: hsa:53354

metaM vacc c
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
initial amount: NaN
boundary condition: false
is: CHEBI:30828
constant: false
name: trans-vaccenate
is: C08367
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM ksi pre22 g
is: C00130
type: Species
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00175
is: SBO:0000247
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 22
notes: FORMULA: C185H297N13O150S6X CHARGE: -7

metaM arachdcoa x
type: Species
has only substance units: false
is: CHEBI:57368
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
boundary condition: false
is: SBO:0000247
name: arachidonoyl-CoA(4-)
is: HMDB06523
initial concentration: 1.0
constant: false

metaM 13dpg c
has only substance units: false
is: C00236
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3535
is: CHEBI:57604
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
is: HMDB01270
type: Species
name: 3-Phospho-D-glyceroyl phosphate
initial amount: NaN
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_3443d5ed_8b86_4e4a_a0ee_9dbed85860d2
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4717
name: NDUFC1
is: O43677
has only substance units: false
boundary condition: true
type: Species

metaR r1773
kinetic law: MODEL1310110056#
is: SBO:0000185
reactant: MODEL1310110056#
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110056#
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110056#_fbe95473_8973_43cc_b701_e48706e3d28b
name: SLC4A5
initial concentration: NaN
is: SBO:0000252
is: Q9BY07
is encoded by: hsa:57835
has only substance units: false
type: Species
constant: false
boundary condition: true
initial amount: NaN

metaM glutcoa m
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: HMDB01339
name: glutaryl-CoA(5-)
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
is: SBO:0000247
type: Species
is: CHEBI:57378
has only substance units: false

metaM k e
constant: false
type: Species
initial amount: NaN
name: potassium
has only substance units: false
is: C00238
is: CHEBI:29103
is: HMDB00586
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_051b5837_37df_4111_b831_3a3462233b57
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q9BV79
type: Species
is encoded by: hsa:51102
name: MECR

http://identifiers.org/biomodels.db/MODEL1310110056#_2db9b422_060a_46c5_ade4_4351c41ac61f
name: PKLR
type: Species
boundary condition: true
is encoded by: hsa:5313
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is: P30613
initial concentration: NaN

metaR DLNLCGCRNt
modifier: MODEL1310110056#
product: MODEL1310110056#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110056#
fast: false
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110056#

metaM accoa r
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
name: acetyl-CoA(4-)
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:57288
is: HMDB01206
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false

metaM dolmanp U r
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
name: Dolichyl phosphate D-mannose, human uterine homolog
is: CHEBI:15809

metaR C10DCc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_5a4dee66_9e64_40af_9f47_e9449959de28
initial amount: NaN
boundary condition: true
is encoded by: hsa:1962
is: SBO:0000252
name: EHHADH
constant: false
is: Q9NY65
initial concentration: NaN
has only substance units: false
type: Species

metaM ksi l
initial concentration: 1.0
type: Species
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
boundary condition: false
is: SBO:0000247
name: keratan sulfate I
is: C00445
is: HMDB01354
constant: false
is: CHEBI:57455
has only substance units: false
initial amount: NaN

metaM tmndnccoa x
initial concentration: 1.0
boundary condition: false
constant: false
name: timnodonyl coenzyme A
is: HMDB06514
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_17c9dbf8_fa7d_45d4_b613_9c63caa567e9
type: Species
is encoded by: hsa:622
constant: false
has only substance units: false
is: Q02338
name: BDH1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR M7MASNBterg
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110056#
product: MODEL1310110056#
name: m7masnB transport from endoplasmic reticulum to Golgi apparatus
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110056#

metaM Nacasp c
is: HMDB00812
initial concentration: 1.0
constant: false
is: SBO:0000247
name: N-acetyl-L-aspartate(2-)
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:16953
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_564213ce_49fa_4927_8e05_f968d9afe159
type: Species
boundary condition: true
name: ALDH3A2
is: SBO:0000252
initial concentration: NaN
is: P51648
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:224

metaM e4p c
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16897
is: SBO:0000247
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
is: C00279
name: D-Erythrose 4-phosphate
type: Species
is: HMDB01321

metaR C142ACBP
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradeca dienoyl coa from mitochondria into cytosol
type: Reaction

metaR r1578
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#

metaM docohepcoa m
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: 2,4,7,10,13,16,19-docosaheptenoylcoa

metaM pchol hs m
constant: false
boundary condition: false
type: Species
name: Phosphatidylcholine
is: CHEBI:16110
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157

metaR SIAASE3ly
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110056#
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110056#
name: sialidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110056#_3679700d_7f17_4def_9aec_df71504d565e
is: Q96C36
type: Species
is encoded by: hsa:29920
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
name: PYCR2

http://identifiers.org/biomodels.db/MODEL1310110056#_51503f14_d7fe_4636_a4c8_ace1cabb8a8b
type: Species
has only substance units: false
is: SBO:0000252
is: Q86YN1
name: DOLPP1
is encoded by: hsa:57171
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN

metaM CE5854 e
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB02710
constant: false
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
is: SBO:0000247
name: gama-CEHC-glucuronide
is: CHEBI:27485
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_a23ec4b7_396c_42cb_b656_1bc7de2ba570
type: Species
has only substance units: false
is encoded by: hsa:3033
name: HADH
is: Q16836
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_823fd599_f917_4efc_941a_4b50f0ebe525
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q9NVE7
boundary condition: true
name: PANK4
type: Species
is encoded by: hsa:55229
constant: false
has only substance units: false

metaR RE0452M
type: Reaction
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
reversible: true
is: SBO:0000176
name: RE0452
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
is described by: ECO:0000000
fast: false

metaM asp D c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:29990
boundary condition: false
is: HMDB06483
type: Species
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
name: D-aspartate(1-)
initial amount: NaN
constant: false

metaR UMPK
fast: false
modifier: MODEL1310110056#
type: Reaction
reversible: true
reactant: MODEL1310110056#
is described by: ECO:0000269
is: SBO:0000176
name: UMP kinase
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110056#
kinetic law: MODEL1310110056#

metaR OCTDECCPT2
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaM k c
is: SBO:0000247
has only substance units: false
type: Species
name: potassium
constant: false
initial amount: NaN
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: C00238
is: CHEBI:29103
initial concentration: 1.0
is: HMDB00586
boundary condition: false

metaR r1579
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110056#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110056#
is: SBO:0000185
reversible: true
product: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_b41f6860_a3e6_4ba3_8366_0235880993e3
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:26290
constant: false
is: SBO:0000252
is: Q9NY28
name: GALNT8

metaM tetdecdicoa m
initial amount: NaN
type: Species
name: 5,8-tetradecadienoylcoa
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB02288
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
has only substance units: false

metaM fuc L l
is: CHEBI:18287
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
constant: false
name: L-fucose
type: Species
boundary condition: false
is: HMDB00174
is: SBO:0000247
initial amount: NaN

metaR KYNATESYN
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
product: MODEL1310110056#
kinetic law: MODEL1310110056#
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
reactant: MODEL1310110056#
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110056#_28b94646_22f4_4259_9d41_040d615c6d16
is: SBO:0000252
constant: false
name: CA12
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:771
initial concentration: NaN
is: O43570

metaR RE0958E
is described by: ECO:0000000
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.1
fast: false
type: Reaction
modifier: MODEL1310110056#
reversible: true
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.17
reactant: MODEL1310110056#
name: RE0958

metaR BUP2
reactant: MODEL1310110056#
product: MODEL1310110056#
is described by: ECO:0000269
modifier: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.6
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:11508704,PMID:5773299 NOTES:MM
fast: false
reversible: false
name: beta-ureidopropionase (D-3-amino-isobutanoate forming)
is: SBO:0000176
kinetic law: MODEL1310110056#

metaR G14T16g
is described by: ECO:0000000
reversible: false
product: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110056#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaM cspg a e
is: SBO:0000247
type: Species
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
is: HMDB00630
boundary condition: false
is: CHEBI:16040
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR APOC LYS BTNP
product: MODEL1310110056#
name: proteolysis of apoC-Lys-btn
reactant: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110056#
is described by: ECO:0000000

metaR r2435
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
kinetic law: MODEL1310110056#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110056#
is described by: ECO:0000000
reversible: false

metaR AG13T1g
reactant: MODEL1310110056#
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110056#
kinetic law: MODEL1310110056#
is: SBO:0000176
modifier: MODEL1310110056#

metaM cspg a l
is: CHEBI:36005
initial amount: NaN
is: HMDB02183
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
constant: false
initial concentration: 1.0
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110056#_37bf26ec_bfec_4254_9a99_a43b18c3d6f1
is: P13686
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:54
is: SBO:0000252
type: Species
constant: false
name: ACP5

metaR DCYTD
reversible: false
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110056#
name: deoxycytidine deaminase
modifier: MODEL1310110056#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/3.5.4.5
reactant: MODEL1310110056#
fast: false
product: MODEL1310110056#

metaR LPASE
reversible: false
name: lysophospholipase
notes: GENE_ASSOCIATION: (5321.1) or (1178.1) or (29124.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9430701 NOTES:phosphatidyl choline degradation NJ
type: Reaction
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.1.5
modifier: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110056#
fast: false
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_b8b5abd2_69de_41d3_bf2b_c4c5d7223778
is encoded by: hsa:6184
is encoded by: hsa:1650
has part: P39656
initial amount: NaN
has only substance units: false
initial concentration: NaN
has part: P04843
has part: Q53G02
is encoded by: hsa:1603
boundary condition: true
is: SBO:0000297
is encoded by: hsa:6185
type: Species
name: DAD1:DDOST:RPN1:RPN2
constant: false
has part: P04844

metaM 3hexdcrn e
constant: false
name: 3-hydroxyhexadecanoylcarnitine
is: HMDB13336
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C23H45NO5 CHARGE: 0
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_a2b1b331_c3fa_4e7a_8730_3fe6211d4dfb
is: P39656
constant: false
is encoded by: hsa:1650
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: DDOST
type: Species

metaR RE2541E
product: MODEL1310110056#
name: RE2541
is version of: http://identifiers.org/ec-code/3.2.1.31
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
fast: false
reversible: true
is: SBO:0000176
modifier: MODEL1310110056#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_ca610354_d06f_420d_9eec_d91d9c506dfd
type: Species
constant: false
is encoded by: hsa:376497
name: SLC27A1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false

metaM ahdt e
is: HMDB00980
initial amount: NaN
is: SBO:0000247
name: 7,8-dihydroneopterin 3'-triphosphate(4-)
notes: FORMULA: C9H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C9H16N5O13P3/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-25-29(21,22)27-30(23,24)26-28(18,19)20/h4,6,15-16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,10,11,13,14,17)/p-4/t4-,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01367 EHMN_ABBREVIATION: C04895
boundary condition: false
has only substance units: false
is: CHEBI:58462
constant: false
type: Species
initial concentration: 1.0

metaR r1428
fast: false
name: Free diffusion
product: MODEL1310110056#
reactant: MODEL1310110056#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
kinetic law: MODEL1310110056#
is described by: ECO:0000000

metaR NAGA2ly
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
product: MODEL1310110056#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
reversible: false
name: N-acetylgalactosaminidase, alpha-
is version of: http://identifiers.org/ec-code/3.2.1.49
fast: false
modifier: MODEL1310110056#

metaR MI4PP
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.3.25
fast: false
product: MODEL1310110056#
modifier: MODEL1310110056#
name: myo-inositol 4-phosphatase
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
type: Reaction

metaR OCTDECCPT1
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaM mercppyr c
boundary condition: false
initial amount: NaN
constant: false
is: HMDB01368
is: SBO:0000247
type: Species
name: 3-mercaptopyruvate
is: CHEBI:57678
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957

metaR r0276
type: Reaction
reactant: MODEL1310110056#
product: MODEL1310110056#
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
fast: false
modifier: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
kinetic law: MODEL1310110056#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21

http://identifiers.org/biomodels.db/MODEL1310110056#_1cff577e_df65_4cb4_963b_8a39eebf410f
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q8TEQ8
has only substance units: false
type: Species
is encoded by: hsa:84720
constant: false
name: PIGO
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_8aff39e7_3769_420d_beed_4bfd5cc7095c
is: P15104
is encoded by: hsa:2752
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: GLUL
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_885ea8f2_6890_49ce_935f_9dd28c5d704b
has only substance units: false
name: SLC25A26
constant: false
boundary condition: true
type: Species
is encoded by: hsa:115286
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM c4dc c
boundary condition: false
notes: FORMULA: C11H18NO6 CHARGE: -1
initial amount: NaN
is: SBO:0000247
constant: false
name: succinyl carnitine
is: http://identifiers.org/pubchem.compound/213144
is: HMDB02013
has only substance units: false
is: C02862
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_59fc700e_a0c3_4350_ad1b_8007b27ecf05
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: CHAT
is: Q6LEN5
has only substance units: false
is encoded by: hsa:1103
type: Species
boundary condition: true

metaR DAGKn hs
product: MODEL1310110056#
name: Diacylglycerol phosphate kinase (homo sapiens)
is version of: http://identifiers.org/ec-code/2.7.1.107
type: Reaction
notes: GENE_ASSOCIATION: (8525.1) or (9162.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
fast: false
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110056#

metaR DCK1n
fast: false
product: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.74
reactant: MODEL1310110056#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110056#
name: Deoxycytidine kinase, nuclear (ATP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
kinetic law: MODEL1310110056#

metaM ksii core4 pre10 g
type: Species
initial amount: NaN
is: CHEBI:28067
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 10
constant: false

metaR r1429
product: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Free diffusion
kinetic law: MODEL1310110056#
type: Reaction
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110056#_7be207fe_bd13_401a_be5e_d44d19e37f8c
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:U37519
boundary condition: true
name: _U37519_1_c
initial amount: NaN
initial concentration: NaN
type: Species

metaM asn L m
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
initial concentration: 1.0
has only substance units: false
is: HMDB00168
type: Species
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:17196
name: L-asparagine

metaM HC00900 c
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: Methylmalonate
is: CHEBI:30860
type: Species
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170

metaR S6T1g
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
modifier: MODEL1310110056#
reactant: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
is: SBO:0000176
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110056#_6f679e2e_ba29_42f4_95cd_d16392014b93
is: P21953
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:594
name: BCKDHB
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252

metaR VACCCRNt
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110056#
reversible: false
fast: false
name: transport into the mitochondria (carnitine)
product: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#

metaR CYTDK1
is version of: http://identifiers.org/ec-code/2.7.1.48
reactant: MODEL1310110056#
name: ATPcytidine 5-phosphotransferase
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
modifier: MODEL1310110056#
type: Reaction
fast: false
is described by: ECO:0000254
kinetic law: MODEL1310110056#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110056#_129b543e_fadf_4a3c_8211_1c672b615867
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
is: Q13423
type: Species
boundary condition: true
name: NNT
is encoded by: hsa:23530
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_49602b4a_016b_4b64_9d0a_eb56e01bf02e
name: HIBADH
type: Species
is: P31937
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:11112

metaM 3hexdcrn c
name: 3-hydroxyhexadecanoylcarnitine
constant: false
is: HMDB13336
has only substance units: false
is: SBO:0000247
notes: FORMULA: C23H45NO5 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species

metaR AG13T10g
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
reversible: false
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
is: SBO:0000176
reactant: MODEL1310110056#
product: MODEL1310110056#

metaR FAOXC103C102m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_aba93ef4_01f1_4978_be06_827fb410e790
is encoded by: hsa:5476
type: Species
constant: false
is: P10619
name: CTSA
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM cs a deg5 l
initial amount: NaN
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
notes: FORMULA: C23H36O24S CHARGE: -2
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:15936

metaR C4DCCACT
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinyl carnitine into cytosol
type: Reaction

metaM nm4masn g
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C54H90N3O40X CHARGE: 0
boundary condition: false
constant: false
is: C05882
initial amount: NaN
type: Species
is: SBO:0000247
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)

http://identifiers.org/biomodels.db/MODEL1310110056#_38b1b530_eceb_48cd_9c79_6212ebeb2f25
is encoded by: hsa:AI222095
boundary condition: true
constant: false
is: SBO:0000252
name: _AI222095_1_m
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR SUBEACTD
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberic acid into cytosol (diffusion)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_930b2f9e_591a_4b95_ac6c_aa9987494861
initial concentration: NaN
is encoded by: hsa:51227
boundary condition: true
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000297
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ

metaM CE4876 r
is: SBO:0000247
initial amount: NaN
is: CHEBI:57923
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
name: delta12-Prostaglandin J2
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876

http://identifiers.org/biomodels.db/MODEL1310110056#_6b29b7e7_3caf_4857_83ff_83e5a6a7206e
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
name: PDE1A
type: Species
is: Q9Y633
is encoded by: hsa:5136

http://identifiers.org/biomodels.db/MODEL1310110056#_8ddffc6e_0332_4ef3_bc28_5ad2a7a25492
type: Species
initial concentration: NaN
name: STARD3
is: B4DUY1
is encoded by: hsa:10948
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_ac462cb6_2a38_45dc_bc28_6437eff67382
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is: Q9UBY0
name: SLC9A2
is encoded by: hsa:6549

metaM andrstandn r
is: SBO:0000247
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
boundary condition: false
type: Species
constant: false
initial amount: NaN
name: 5alpha-androstane-3,17-dione
has only substance units: false
is: HMDB00899
initial concentration: 1.0
is: CHEBI:15994

metaM dhcholoylcoa x
is: CHEBI:27393
boundary condition: false
is: HMDB06895
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
type: Species
has only substance units: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA
is: SBO:0000247

metaR EX ddece1crn
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dodecenoyl carnitine
type: Reaction

metaR FAOXC141C121m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C12:1)m
type: Reaction

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaM lnlc c
initial amount: NaN
is: SBO:0000247
is: HMDB00673
constant: false
initial concentration: 1.0
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
name: linoleate
type: Species
is: CHEBI:30245
has only substance units: false
boundary condition: false

metaR AHC
fast: false
reactant: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
is version of: http://identifiers.org/ec-code/3.3.1.1
reversible: true
name: adenosylhomocysteinase
kinetic law: MODEL1310110056#
is described by: ECO:0000269
modifier: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110056#_9c0c239c_44d2_4f01_ab01_dbcd700b5f2e
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:1384
name: CRAT
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaR r0196
modifier: MODEL1310110056#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
fast: false
reactant: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176
kinetic law: MODEL1310110056#
product: MODEL1310110056#

metaM glu L e
is: HMDB00148
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
constant: false
name: L-glutamate(1-)
initial amount: NaN
is: CHEBI:29985

metaM pchol hs e
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
is: CHEBI:16110
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
name: Phosphatidylcholine

http://identifiers.org/biomodels.db/MODEL1310110056#_c6d686de_bebb_45c2_8315_9fa8d6a239f8
is: Q15274
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: QPRT
has only substance units: false
is encoded by: hsa:23475
constant: false
type: Species
boundary condition: true

metaR THRCYSNaEx
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
modifier: MODEL1310110056#
is described by: ECO:0000269
fast: false
name: L-cysteine/L-threonine Na-dependent exchange (Thr-L in)
type: Reaction
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000185

metaM g3m8mpdol U r
has only substance units: false
notes: FORMULA: C1905H3140N20O770P20 CHARGE: -20
is: C05873
type: Species
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM eicostet c
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB02177
initial concentration: 1.0
is: CHEBI:36033
has only substance units: false
name: eicosatetranoic acid
boundary condition: false
type: Species
notes: FORMULA: C20H31O2 CHARGE: -1

metaM hs deg15 l
initial amount: NaN
is: CHEBI:16126
name: heparan sulfate, degradation product 15
is: SBO:0000247
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_493657ca_0074_435b_9ddb_f5b2730e8199
is: SBO:0000252
name: TPI1P2
is encoded by: hsa:286016
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
constant: false
initial amount: NaN

metaR FAOXC14C14OHm
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C14OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_028aad49_6b51_4892_8363_9c569d1032ac
name: PDE2A
boundary condition: true
has only substance units: false
is encoded by: hsa:5138
constant: false
is: Q8IW54
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR LNLCCPT1
reactant: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000269
name: carnitine O-palmitoyltransferase
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
fast: false
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110056#_0d5d31cb_2b9d_42b5_a643_8579ada83ecf
has only substance units: false
name: MECR
is: Q9BV79
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:51102
boundary condition: true
type: Species
initial amount: NaN

metaM lneldccoa m
has only substance units: false
type: Species
is: HMDB01064
constant: false
is: http://identifiers.org/pubchem.compound/5462164
boundary condition: false
is: SBO:0000247
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
initial amount: NaN
name: linoelaidyl coenzyme A
initial concentration: 1.0

metaM HC02205 c
initial amount: NaN
is: CHEBI:28099
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
initial concentration: 1.0
constant: false
name: prostaglandin-b2
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species

metaM fuc L c
has only substance units: false
name: L-fucose
is: CHEBI:18287
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
boundary condition: false
is: HMDB00174

metaM tmndnccoa m
is: HMDB06514
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
initial amount: NaN
boundary condition: false
name: timnodonyl coenzyme A
constant: false

metaR ADRNCPT2
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
name: carnitine transferase
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000176
modifier: MODEL1310110056#
is described by: ECO:0000000

metaM CE5788 e
is: CHEBI:27485
constant: false
boundary condition: false
initial amount: NaN
name: kinetensin 1-7
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB02710

metaM pchol hs g
is: CHEBI:16110
type: Species
initial concentration: 1.0
name: Phosphatidylcholine
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157

metaR C181CPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
type: Reaction
kinetic law: MODEL1310110056#
fast: false
modifier: MODEL1310110056#
name: transport of Octadecenoyl-CoA into mitochondrial matrix
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110056#_97bf1909_8a38_4fc4_a089_48fac60a43a5
constant: false
is encoded by: hsa:10786
type: Species
has only substance units: false
is: O00476
name: SLC17A3
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110056#_b51638aa_55a4_4c83_bf47_2afbae9e3272
initial amount: NaN
name: SLC2A13
type: Species
is encoded by: hsa:114134
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q96QE2

metaR PPNCL3
is version of: http://identifiers.org/ec-code/6.3.2.5
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110056#
name: phosphopantothenate-cysteine ligase
kinetic law: MODEL1310110056#
fast: false
product: MODEL1310110056#
reversible: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110056#
is described by: ECO:0000269

metaR 3MOPte
reversible: true
fast: false
is: SBO:0000185
name: Transport of 3-methyl-2-oxopentanoate
is described by: ECO:0000134
product: MODEL1310110056#
kinetic law: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR EX 3octdeccrn
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyoctadecanoyl carnitine
type: Reaction

metaM eicostet e
is: SBO:0000247
constant: false
is: HMDB02177
is: CHEBI:36033
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
name: eicosatetranoic acid
initial amount: NaN
notes: FORMULA: C20H31O2 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110056#_11aa741d_8c2d_4bda_80f6_9a47e14d1341
boundary condition: true
initial concentration: NaN
is: B3KNC1
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
name: UPB1
has only substance units: false
is encoded by: hsa:51733

metaR r0193
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110056#
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1

metaR 34HPPOR
is version of: http://identifiers.org/ec-code/1.13.11.27
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reactant: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
reversible: false
kinetic law: MODEL1310110056#
fast: false
is described by: ECO:0000269

metaR ADRNCPT1
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
name: carnitine O-palmitoyltransferase
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110056#
is described by: ECO:0000000
reactant: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_60c7dabd_af1a_495f_a273_ad09275db4d1
boundary condition: true
initial amount: NaN
type: Species
name: RDH11
is encoded by: hsa:51109
is: B4DDW0
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false

metaR C181CPT2
modifier: MODEL1310110056#
name: transport of Octadecenoyl-CoA into mitochondrial matrix
fast: false
kinetic law: MODEL1310110056#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110056#
type: Reaction
reversible: false
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV

metaM accoa n
is: CHEBI:57288
initial amount: NaN
name: acetyl-CoA(4-)
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB01206
initial concentration: 1.0
type: Species
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
has only substance units: false

metaR FAOXTC122TC101m
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C12:2-->C10:1)m
type: Reaction

metaR C162OHc
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxy hexadecadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_2b313065_dbe4_461e_91a7_74d6671ae297
has only substance units: false
is encoded by: hsa:2194
name: FASN
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
is: P49327
boundary condition: true
initial concentration: NaN

metaM 6thf e
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/169691
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
name: hexaglutamyl folate (THF)
initial amount: NaN
has only substance units: false

metaM idp e
is: SBO:0000247
name: IDP(3-)
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB03335
boundary condition: false
is: CHEBI:58280
constant: false
initial amount: NaN
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104

metaM 2mb2coa c
is: HMDB02054
constant: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
name: 2-methylcrotonoyl-CoA(4-)
has only substance units: false
initial amount: NaN

metaM asn L c
is: HMDB00168
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
has only substance units: false
is: CHEBI:17196
name: L-asparagine
is: SBO:0000247

metaM asp D e
is: HMDB06483
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: D-aspartate(1-)
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
type: Species
is: SBO:0000247
is: CHEBI:29990

metaM HC02205 e
type: Species
is: CHEBI:28099
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
name: prostaglandin-b2
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954

http://identifiers.org/biomodels.db/MODEL1310110056#_2c12172e_dbe2_47c5_9b26_4c83ae8de04e
initial concentration: NaN
boundary condition: true
name: UCKL1
is encoded by: hsa:54963
has only substance units: false
is: SBO:0000252
type: Species
constant: false
is: Q53HM1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_e1a8ceda_71a3_444e_84c6_cfdb44098054
is: SBO:0000252
type: Species
is: Q96QD8
constant: false
name: SLC38A2
is encoded by: hsa:54407
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN

metaM 3ivcoa m
type: Species
name: 3-hydroxyisovalerylcoa
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/11966188
initial concentration: 1.0
boundary condition: false
is: C05998
is: HMDB06870
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_6a6bb131_9435_40cc_a38e_96a9c8291998
is: Q9C0J1
is: SBO:0000252
initial concentration: NaN
name: B3GNT4
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:79369
constant: false
has only substance units: false

metaR HDECAACBP
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecanoylcoa from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_25cf574d_b27f_4916_9b8d_c61b2d9ab7e2
is: Q96SL4
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:2882
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: GPX7
type: Species

metaM 3octdece1coa m
name: 3-hydroxyoctadecenoylcoa
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280355
type: Species
boundary condition: false
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_0c6a168c_7bd0_402f_9fdf_3dbe94a472a2
type: Species
is: SBO:0000252
initial amount: NaN
name: MDH1B
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:130752
has only substance units: false
is: Q5I0G3

metaM accoa m
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: Acetyl-CoA
initial amount: NaN
constant: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: C00024
is: SBO:0000247
is: HMDB01206
is: CHEBI:57288
type: Species

metaR RE3273C
reactant: MODEL1310110056#
name: RE3273
is: SBO:0000176
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
is described by: ECO:0000000
product: MODEL1310110056#
fast: false
reversible: true
kinetic law: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.4
modifier: MODEL1310110056#

metaR PSFLIPm
is version of: http://identifiers.org/ec-code/3.6.3.1
is: SBO:0000185
type: Reaction
reversible: false
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
name: phosphatidylserine flippase
fast: false
modifier: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000269
product: MODEL1310110056#

metaR r1421
kinetic law: MODEL1310110056#
type: Reaction
reactant: MODEL1310110056#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: Free diffusion
product: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110056#_2c5ca5c3_ef8a_44c0_a928_9c4dc3914c12
is encoded by: hsa:112
type: Species
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: ADCY6
is: SBO:0000252

metaR r1167
is described by: ECO:0000000
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
reversible: false
type: Reaction
fast: false
product: MODEL1310110056#
is: SBO:0000176
name: EC:2.3.1.26

http://identifiers.org/biomodels.db/MODEL1310110056#_7ea7854c_7cac_461e_bab5_4624569ab1be
name: SLC17A1
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:6568
type: Species
initial amount: NaN
has only substance units: false
is: Q14916
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_4ed22454_6fd4_447c_a4cd_f36202e9cdb3
boundary condition: true
has only substance units: false
is: Q8NCG5
type: Species
is encoded by: hsa:10164
name: CHST4
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_bd1af1d8_22be_4047_98ee_fba7d4ab38f8
is: SBO:0000252
has only substance units: false
name: SLC7A5
initial amount: NaN
constant: false
is encoded by: hsa:8140
initial concentration: NaN
boundary condition: true
type: Species
is: Q8IV97

metaR GALt4
name: galactose transport via sodium symport
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reversible: true
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
fast: false
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000185

metaM idp c
type: Species
is: CHEBI:58280
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
constant: false
is: HMDB03335
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: IDP(3-)

metaR C162OHe
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C16:2OH
type: Reaction

metaM lnlc e
name: linoleate
has only substance units: false
is: CHEBI:30245
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00673

http://identifiers.org/biomodels.db/MODEL1310110056#_53bbbb88_e03f_407b_9d33_291bbba26788
is encoded by: hsa:79611
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
is: Q9H6R3
name: ACSS3
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_2a8aec2b_7cf2_4711_97c6_f0a5ad481ba2
boundary condition: true
has only substance units: false
is encoded by: hsa:64078
initial concentration: NaN
name: SLC28A3
is: Q9HAS3
is: SBO:0000252
initial amount: NaN
type: Species
constant: false

metaM oaa c
type: Species
notes: FORMULA: C4H2O5 CHARGE: -2
has only substance units: false
boundary condition: false
is: C00036
is: SBO:0000247
constant: false
is: HMDB00223
name: Oxaloacetate
initial concentration: 1.0
is: CHEBI:3338
initial amount: NaN

metaM asn L e
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
has only substance units: false
initial concentration: 1.0
is: HMDB00168
is: CHEBI:17196
name: L-asparagine
type: Species
constant: false

metaR r0908
reversible: true
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
name: Postulated transport reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110056#_55d79500_27ac_4a77_bd68_8df7d1630b1d
has only substance units: false
type: Species
name: TXNRD1
is: SBO:0000252
is encoded by: hsa:7296
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaM pchol hs c
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
name: Phosphatidylcholine
is: CHEBI:16110
type: Species
initial amount: NaN

metaR GASNASEly
type: Reaction
name: glycosylasparaginase, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.5.1.26
modifier: MODEL1310110056#
fast: false
reactant: MODEL1310110056#
is: SBO:0000176
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false

metaM glu L c
is: SBO:0000247
initial concentration: 1.0
name: L-glutamate(1-)
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:29985
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: HMDB00148

metaM n2m2nmasn e
initial concentration: 1.0
initial amount: NaN
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
has only substance units: false
type: Species
is: SBO:0000247
is: C04946
boundary condition: false
notes: FORMULA: C58H96N5O40X CHARGE: 0
constant: false

metaR 5MTHFt2le
reactant: MODEL1310110056#
product: MODEL1310110056#
name: 5-methyltetrahydrofolate transport via anion exchange
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110056#
is described by: ECO:0000134
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_b40789e3_eb95_4a8e_a609_048c1fd3f782
name: TALDO1
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6888
is: P37837
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species

metaM r5p c
initial concentration: 1.0
type: Species
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
is: C00117
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00618
initial amount: NaN
boundary condition: false
name: alpha-D-Ribose 5-phosphate
is: CHEBI:18189

metaR NS26T2g
notes: GENE_ASSOCIATION: (55808.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.3 Confidence Level: 0 AUTHORS: PMID:10536037 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.3
kinetic law: MODEL1310110056#
is: SBO:0000176
product: MODEL1310110056#
fast: false
reactant: MODEL1310110056#
modifier: MODEL1310110056#
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
reversible: false
is described by: ECO:0000000

metaM 3otdcoa x
is: SBO:0000247
is: CHEBI:28726
name: 3-Oxotetradecanoyl-CoA
constant: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
boundary condition: false
is: HMDB03935
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR r1431
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000
type: Reaction
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110056#
fast: false

metaM 12ppd R c
initial concentration: 1.0
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
constant: false
is: CHEBI:28972
type: Species
initial amount: NaN
is: HMDB01881
boundary condition: false
name: (R)-propane-1,2-diol
has only substance units: false
is: SBO:0000247

metaR HESTRATRIOLtr
reversible: true
fast: false
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be transported out of the cell NJ
product: MODEL1310110056#
is: SBO:0000185
is described by: ECO:0000000
name: hydroxylated estrogen derivative transport
type: Reaction
kinetic law: MODEL1310110056#

metaM CE2421 m
is: HMDB02329
constant: false
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
is: CHEBI:30623
has only substance units: false
name: (3S)-3-hydroxylinoleoyl-CoA

metaR DPCOAPPe
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
reversible: false
type: Reaction
name: Pyrophasphatase (dephospho-CoA, extracellular)
fast: false
is: SBO:0000176
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
product: MODEL1310110056#

metaR PEPCKm
fast: false
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/4.1.1.32
product: MODEL1310110056#
type: Reaction
reversible: false
name: Phosphoenolpyruvate carboxykinase (GTP)
reactant: MODEL1310110056#
is described by: ECO:0000000
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110056#_8322a044_a868_4f12_892a_140946992c0e
name: AK2
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P54819
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:204
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_f35aa4d8_c57f_4f41_ac88_c5e1a3bc7d5b
is: P23434
constant: false
is encoded by: hsa:2653
initial concentration: NaN
name: GCSH
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false

metaR FAOXC103C102x
kinetic law: MODEL1310110056#
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)x
type: Reaction

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_37ca9dfb_9e53_4384_ad87_a21c4c8abc8d
constant: false
type: Species
initial concentration: NaN
boundary condition: true
name: NNT
is encoded by: hsa:23530
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaM udp n
initial concentration: 1.0
name: UDP(3-)
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00295
is: CHEBI:58223
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
has only substance units: false
type: Species
constant: false

metaR CYTK6n
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110056#
product: MODEL1310110056#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110056#
name: cytidylate kinase (CMP,CTP),nuclear
modifier: MODEL1310110056#
type: Reaction

metaM 2hb c
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:1148
is: SBO:0000247
boundary condition: false
name: 2-Hydroxybutyrate
is: HMDB00008

metaR GLCt1r
fast: false
name: glucose transport (uniport)
is described by: ECO:0000269
kinetic law: MODEL1310110056#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
reversible: true
reactant: MODEL1310110056#

metaM HC01410 m
type: Species
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
is: CHEBI:28706
initial concentration: 1.0
name: (2E)-Hexenoyl-CoA

metaR URIt
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
modifier: MODEL1310110056#
product: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
name: uridine facilated transport in cytosol
is described by: ECO:0000269

metaM leuktrD4 c
constant: false
type: Species
is: HMDB03080
name: Leukotriene D4
is: SBO:0000247
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28666
boundary condition: false

metaM ctp n
is: CHEBI:37563
is: HMDB00082
initial concentration: 1.0
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
has only substance units: false
is: SBO:0000247
constant: false
type: Species
name: CTP(4-)
initial amount: NaN
boundary condition: false

metaR RE2660N
kinetic law: MODEL1310110056#
is version of: http://identifiers.org/ec-code/4.2.1.96
type: Reaction
modifier: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000
product: MODEL1310110056#
fast: false
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
reversible: true
is: SBO:0000176
name: RE2660

http://identifiers.org/biomodels.db/MODEL1310110056#_f57b91f8_24bd_4fa1_a2a8_124d8bfaeae5
is: P32322
is encoded by: hsa:5831
initial concentration: NaN
name: PYCR1
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaM ksi deg12 l
boundary condition: false
initial amount: NaN
is: CHEBI:12936
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
initial concentration: 1.0
constant: false
is: SBO:0000247
name: keratan sulfate I, degradation product 12
type: Species
is: HMDB00143
has only substance units: false

metaR P4508B11r
reversible: false
name: sterol 12-alpha-hydroxylase
is: SBO:0000176
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
type: Reaction
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/1.14.13.95
is described by: ECO:0000269
fast: false
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#

metaR S6TASE9ly
product: MODEL1310110056#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
reactant: MODEL1310110056#
modifier: MODEL1310110056#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: true
kinetic law: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
name: N-acetylgalactosamine-6-sulfatase, lysosomal

metaR NDP3ex
is version of: http://identifiers.org/ec-code/3.6.1.6
is described by: ECO:0000269
kinetic law: MODEL1310110056#
reversible: false
name: nucleoside-diphosphatase (GDP), extracellular
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
reactant: MODEL1310110056#
is: SBO:0000176
fast: false
product: MODEL1310110056#
type: Reaction

metaR r2535
reactant: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#
is described by: ECO:0000000
product: MODEL1310110056#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaR SQLEr
reversible: false
reactant: MODEL1310110056#
modifier: MODEL1310110056#
kinetic law: MODEL1310110056#
is described by: ECO:0000134
fast: false
name: Squalene epoxidase, endoplasmic reticular (NADP)
type: Reaction
is: SBO:0000176
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.14.13.132

http://identifiers.org/biomodels.db/MODEL1310110056#_5dea34a6_23ed_4803_9af0_85d9f202a605
is: P00414
constant: false
is: SBO:0000252
name: COX3
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:4514
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_45a23df3_0f10_4177_bc7c_eab4e4326437
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:83549
name: UCK1
constant: false
initial concentration: NaN
has only substance units: false
is: Q5JT09
is: SBO:0000252

metaM hdcea r
initial amount: NaN
initial concentration: 1.0
name: palmitoleate
type: Species
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
boundary condition: false
is: SBO:0000247
is: CHEBI:32372
has only substance units: false
constant: false
is: HMDB03229

metaM ctp m
initial concentration: 1.0
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: HMDB00082
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
constant: false
name: CTP(4-)
is: CHEBI:37563
initial amount: NaN

metaM gal c
has only substance units: false
is: C00124
is: SBO:0000247
is: CHEBI:0
initial concentration: 1.0
boundary condition: false
name: D-Galactose
is: HMDB00143
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0
type: Species
initial amount: NaN

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110056#_11cb2c6b_3efe_4a33_9beb_29f1654e1ca8
is: SBO:0000252
is: Q16795
is encoded by: hsa:4704
has only substance units: false
type: Species
initial concentration: NaN
constant: false
boundary condition: true
name: NDUFA9
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_9b3e62f7_1f67_44be_88d1_fb54d0a0996d
boundary condition: true
constant: false
type: Species
is: E5KSL6
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1716
initial concentration: NaN
has only substance units: false
name: DGUOK

http://identifiers.org/biomodels.db/MODEL1310110056#_ba556c98_2630_423b_aaf4_fceb4bd93a9f
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
is: P23634
initial concentration: NaN
is encoded by: hsa:493
has only substance units: false
name: ATP2B4

metaM HC00342 c
type: Species
initial concentration: 1.0
name: cis-aconitate(3-)
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
is: CHEBI:16383

metaR r2534
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
product: MODEL1310110056#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaM udp l
initial concentration: 1.0
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
constant: false
is: HMDB00295
is: CHEBI:58223
initial amount: NaN
name: UDP(3-)
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_ac64ae71_9819_4890_aa5f_10afd8b9a4d6
is: Q8NFL0
initial concentration: NaN
name: B3GNT7
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:93010

metaM lgt S c
name: (R)-S-lactoylglutathionate(1-)
constant: false
type: Species
is: CHEBI:57474
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
is: HMDB01066
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM stcoa m
is: HMDB01114
type: Species
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
boundary condition: false
is: CHEBI:57394
initial concentration: 1.0
name: Stearoyl-CoA (n-C18:0CoA)
initial amount: NaN
is: C00412

metaR r0801
fast: false
kinetic law: MODEL1310110056#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
reactant: MODEL1310110056#
is: SBO:0000185
product: MODEL1310110056#
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:

metaR FACOAL200
name: fatty-acid--CoA ligase
modifier: MODEL1310110056#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110056#
product: MODEL1310110056#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
fast: false
is described by: ECO:0000269
reactant: MODEL1310110056#
reversible: true

metaM lnlncgcoa c
constant: false
is: SBO:0000247
is: HMDB06368
has only substance units: false
initial concentration: 1.0
type: Species
name: gamma-linolenoyl-CoA(4-)
is: CHEBI:57363
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110056#_43aaab2c_b6f5_424a_b71a_f535c70652b2
name: HK1
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3098
boundary condition: true
has only substance units: false
is: A8K7J7
type: Species
initial concentration: NaN

metaM leuktrD4 e
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
constant: false
has only substance units: false
initial amount: NaN
name: Leukotriene D4
type: Species
boundary condition: false
is: HMDB03080
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28666

metaM CE1926 e
type: Species
is: HMDB00127
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:15748
name: gama-carboxyethyl-hydroxychroman

metaM dadp c
is: SBO:0000247
is: CHEBI:57667
initial concentration: 1.0
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
boundary condition: false
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: dADP
is: C00206
is: HMDB01508

http://identifiers.org/biomodels.db/MODEL1310110056#_eccb99a7_a4a1_48a7_8f8b_dd9e63cae5a3
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:9365
is: Q9UEF7
boundary condition: true
name: KL
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_923bb995_f1c3_48d1_89a1_7122936a09b8
is: SBO:0000252
is encoded by: hsa:9583
constant: false
name: ENTPD4
initial amount: NaN
has only substance units: false
is: Q9Y227
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_491ccd20_1a11_4403_94ea_f046c0f858aa
is: SBO:0000252
initial amount: NaN
constant: false
name: ENPP1
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:5167
is: P22413
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110056#_70160379_0cbb_41a8_8f21_576ab2b2e34e
is encoded by: hsa:4967
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q02218
constant: false
name: OGDH
type: Species

metaM hs deg6 l
is: SBO:0000247
name: heparan sulfate, degradation product 6
type: Species
is: HMDB06210
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_627a2b36_51b5_416d_9497_654380b5afa6
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:AI935189
initial amount: NaN
name: _AI935189_1_m
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110056#_2f8f5ac8_f14a_48c1_90ca_70ddb8753f1e
is: O43678
constant: false
name: NDUFA2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4695
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_4412f331_0038_428d_9d0b_ff218fb87f8b
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
is: P14555
is encoded by: hsa:5320
initial amount: NaN
has only substance units: false
name: PLA2G2A

metaR S6TASE25ly
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
kinetic law: MODEL1310110056#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: true
modifier: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110056#
name: galactose-6-sulfate sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5

metaM ksi pre23 g
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 23
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
initial amount: NaN
is: SBO:0000247

metaR r2100
reversible: true
product: MODEL1310110056#
reactant: MODEL1310110056#
is described by: ECO:0000000
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110056#
is: SBO:0000185
type: Reaction
fast: false

metaM fmn c
is: CHEBI:58210
name: FMN
initial concentration: 1.0
initial amount: NaN
is: HMDB01520
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
constant: false
is: C00061
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247

metaR r1580
reversible: true
reactant: MODEL1310110056#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110056#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110056#
is described by: ECO:0000000

metaR MI1345PP
reactant: MODEL1310110056#
reversible: false
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
kinetic law: MODEL1310110056#
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is described by: ECO:0000269
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.86
type: Reaction
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/3.1.3.36

metaR CSND
is described by: ECO:0000000
name: Cytosine deaminase
is: SBO:0000176
fast: false
product: MODEL1310110056#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
reactant: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#

metaR DCYTt
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110056#
reactant: MODEL1310110056#
kinetic law: MODEL1310110056#
name: deoxycytidine transport via diffusion
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:

metaR MI145PK
fast: false
name: inositol-1,4,5-trisphosphate 3-kinase
reactant: MODEL1310110056#
type: Reaction
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110056#
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
product: MODEL1310110056#
is version of: http://identifiers.org/ec-code/2.7.1.127
kinetic law: MODEL1310110056#
is: SBO:0000176

metaM dcsptn1crn m
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB06321
type: Species
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
constant: false
name: docosa-4,7,10,13,16-pentaenoyl carnitine

metaM m7mpdol U r
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:37636
initial amount: NaN
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1665H2740N20O570P20 CHARGE: -20
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_26c42425_f57e_4661_969b_042f1fa51b23
initial amount: NaN
name: HEXB
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:3074
is: P07686

http://identifiers.org/biomodels.db/MODEL1310110056#_0768a043_ce46_48a0_a091_eac468545ecf
initial amount: NaN
is: Q59EA4
boundary condition: true
has only substance units: false
constant: false
name: PLD1
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:5337

metaR D LACt2
modifier: MODEL1310110056#
is: SBO:0000185
reversible: true
name: D-lactate transport via proton symport
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
is described by: ECO:0000269
fast: false
reactant: MODEL1310110056#
product: MODEL1310110056#
type: Reaction
kinetic law: MODEL1310110056#

http://identifiers.org/biomodels.db/MODEL1310110056#_dccdb752_93bf_4932_b902_3f9d8ac5ea72
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: _H53099_1_m
is encoded by: hsa:H53099
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110056#_399630bc_8916_4928_9947_7ac8d74ebbd9
has only substance units: false
initial concentration: NaN
is encoded by: hsa:54677
is: SBO:0000252
boundary condition: true
is: E7EQF2
type: Species
name: CROT
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110056#_37315e04_353a_4121_9422_0906eccf46a2
type: Species
is: Q8TD30
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:84706
boundary condition: true
is: SBO:0000252
name: GPT2

http://identifiers.org/biomodels.db/MODEL1310110056#_c6d6ece8_3e9a_4ca7_8cb5_b54bfd3e4e33
is encoded by: hsa:8818
has part: O94777
constant: false
has only substance units: false
name: DPM3:DPM1:DPM2
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has part: Q86TM7
is encoded by: hsa:8813
is encoded by: hsa:54344
is: SBO:0000297
has part: O60762

metaM c8dc c
name: suberyl carnitine
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: HMDB00791
is: SBO:0000247
notes: FORMULA: C15H26NO6 CHARGE: -1
is: C02838
boundary condition: false

metaR FAOXC16080x
fast: false
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110056#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110056#
reversible: false
modifier: MODEL1310110056#
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM duri n
name: 2'-deoxyuridine
is: CHEBI:16450
initial amount: NaN
type: Species
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00012
boundary condition: false
is: SBO:0000247

metaR EX chtn LPAREN e RPAREN
kinetic law: MODEL1310110056#
reactant: MODEL1310110056#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chitin exchange
type: Reaction

metaM h x
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: CHEBI:24636
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
is: C00080
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: proton
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110056#_009bf4a4_6135_46e2_8b92_43c72de1bc3e
boundary condition: true
type: Species
initial amount: NaN
name: GGT5
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is: P36269
is encoded by: hsa:2687