http://identifiers.org/biomodels.db/MODEL1310110055#_9b8042da_5462_4db3_925d_b1b5654b2684
is encoded by: hsa:229
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
name: ALDOB
is: P05062
initial amount: NaN
type: Species

metaM f1a l
type: Species
has only substance units: false
name: F1alpha
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: SBO:0000247
is: CHEBI:17151
boundary condition: false
initial concentration: 1.0
is: HMDB02917
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_539b8c65_bfc9_4355_ae95_08d4377103f3
boundary condition: true
initial amount: NaN
constant: false
name: INPPL1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: O15357
type: Species
is encoded by: hsa:3636

metaR 5MTAte
kinetic law: MODEL1310110055#
name: Transport of 5-S-methyl-5-thioadenosine
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reversible: true
is described by: ECO:0000134
product: MODEL1310110055#
is: SBO:0000185
reactant: MODEL1310110055#

metaM bilirub e
type: Species
is: SBO:0000247
name: bilirubin(2-)
boundary condition: false
constant: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
has only substance units: false
initial concentration: 1.0
is: CHEBI:57977
initial amount: NaN
is: HMDB00054

http://identifiers.org/biomodels.db/MODEL1310110055#_aa63cb32_1052_4519_89ea_2a54e2c327f2
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:33
is: P28330
is: SBO:0000252
name: ACADL

metaR r1018
kinetic law: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#
name: Transport reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:

metaR ACNAMlt
kinetic law: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
product: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
reactant: MODEL1310110055#
is described by: ECO:0000269
name: N-acetylneuraminate transport into lysososme
is: SBO:0000185
reversible: true

metaR GGH 6THFe
reversible: false
product: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (6THF), extracellular
kinetic law: MODEL1310110055#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
modifier: MODEL1310110055#
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_9a1b0938_6e41_4180_8937_ec3f91d29de4
is: SBO:0000252
initial amount: NaN
name: LDHC
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3948
has only substance units: false
constant: false
type: Species

metaR SRTNt6 2 r
modifier: MODEL1310110055#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110055#
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
product: MODEL1310110055#
is described by: ECO:0000269
kinetic law: MODEL1310110055#
fast: false

metaR FORtr
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
kinetic law: MODEL1310110055#
type: Reaction
name: FOR transporter, endoplasmic reticulum
product: MODEL1310110055#

metaR RE0569E
is: SBO:0000176
notes: GENE_ASSOCIATION: (4017.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
fast: false
reactant: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000000
modifier: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#
type: Reaction
name: RE0569

http://identifiers.org/biomodels.db/MODEL1310110055#_1368c8b2_89b1_49fc_bd54_0d467ce17202
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:291
initial amount: NaN
initial concentration: NaN
type: Species
name: SLC25A4
has only substance units: false
is: P12235

metaR UGALGTg
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
name: UDPgalactose:D-glucose 4-beta-D-galactosyltransferase, Golgi apparatus
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3906.1) and (2683.1) or (8704.2) or (8704.1) SUBSYSTEM: Galactose metabolism EC Number: 2.4.1.22 Confidence Level: 4 AUTHORS: PMID:11419947 NOTES:NCD
is: SBO:0000176
fast: false
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_309865d2_501e_4c5b_bbb9_95eb6c73f718
is: SBO:0000252
name: PLA2G3
is encoded by: hsa:50487
initial concentration: NaN
constant: false
is: Q9NZ20
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_0f16db05_75d8_4a6f_a1af_e5d2ab92f0df
is encoded by: hsa:4712
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: O95139
is: SBO:0000252
name: NDUFB6
initial concentration: NaN
constant: false

metaR DAGKn hs
notes: GENE_ASSOCIATION: (8525.1) or (9162.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
name: Diacylglycerol phosphate kinase (homo sapiens)
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.107
fast: false
modifier: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
reversible: true

metaM Rtotal2coa c
type: Species
constant: false
initial concentration: 1.0
is: HMDB01564
initial amount: NaN
is: CHEBI:57876
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
is: SBO:0000247
boundary condition: false
name: R total 2 coenzyme A
has only substance units: false

metaR r1019
product: MODEL1310110055#
is: SBO:0000185
type: Reaction
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000000
reversible: true
fast: false

metaM hs deg19 l
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
type: Species
has only substance units: false
is: CHEBI:17180
constant: false
initial amount: NaN
is: HMDB01352
is: SBO:0000247
boundary condition: false
name: heparan sulfate, degradation product 19
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_89981734_8d35_479d_887c_2b2586687c28
has only substance units: false
type: Species
is encoded by: hsa:8818
is encoded by: hsa:5277
is encoded by: hsa:5283
is encoded by: hsa:9091
has part: Q14442
is encoded by: hsa:51227
has part: O94777
boundary condition: true
is encoded by: hsa:5279
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has part: B3KUV7
has part: Q92535
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
constant: false
has part: Q9BRB3

metaR FAOXC205C184x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_be88914a_ce27_4f2e_af36_f004c2ac3465
is encoded by: hsa:10423
name: CDIPT
is: SBO:0000252
is: A8K3L7
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR MTHFC
type: Reaction
product: MODEL1310110055#
fast: false
name: methenyltetrahydrofolate cyclohydrolase
is version of: http://identifiers.org/ec-code/1.5.1.5
modifier: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
is described by: ECO:0000134
reactant: MODEL1310110055#
is: SBO:0000176
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.5.4.9

metaM cspg b l
has only substance units: false
is: CHEBI:36005
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
is: HMDB02183
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
constant: false
initial concentration: 1.0

metaM 4ppcys m
is: CHEBI:59458
type: Species
is: SBO:0000247
is: HMDB01117
initial concentration: 1.0
constant: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
has only substance units: false
initial amount: NaN
boundary condition: false
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)

metaM dutp c
is: C00460
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: dUTP
type: Species
is: HMDB01191
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: CHEBI:17625

metaM 3hodcoa c
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00712
name: (S)-3-Hydroxyoctadecanoyl-CoA
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false

metaM dolp L r
is: CHEBI:57683
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
boundary condition: false
is: SBO:0000247
type: Species
name: dolichyl phosphate(2-)
constant: false

metaM acrn c
name: O-acetylcarnitine
has only substance units: false
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: CHEBI:57589
boundary condition: false
is: HMDB00201
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
initial concentration: 1.0

metaR FAOXC5C5DCc
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of glutaryl carnitine
type: Reaction

metaR PHEtec
product: MODEL1310110055#
is described by: ECO:0000269
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (117247.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462,PMID:14624363,PMID:15659399 NOTES:SAB
kinetic law: MODEL1310110055#
is: SBO:0000185
name: L-phenylalanine transport via diffusion (extracellular to cytosol)
modifier: MODEL1310110055#
fast: false
reversible: true
type: Reaction

metaM dec47dicoa x
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
name: 4,7-decadienoylcoa
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_61c6b690_c625_4326_b1e1_75b9f1f4aad0
is: SBO:0000252
is encoded by: hsa:10861
initial amount: NaN
has only substance units: false
constant: false
name: SLC26A1
boundary condition: true
initial concentration: NaN
type: Species

metaR MTHFD
fast: false
type: Reaction
product: MODEL1310110055#
is described by: ECO:0000134
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.5.1.5
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
reversible: true
name: methylenetetrahydrofolate dehydrogenase (NADP)
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110055#_9bf8dd58_dd1a_46f5_9d9c_b667d0debe4d
is encoded by: hsa:1595
has only substance units: false
name: CYP51A1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: Q16850

metaM pheme m
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
initial concentration: 1.0
is: CHEBI:17627
boundary condition: false
constant: false
name: Protoheme
has only substance units: false
is: C00032
initial amount: NaN
is: SBO:0000247
is: HMDB03178
type: Species

metaR GCNTg
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.150
name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
product: MODEL1310110055#
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (2651.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.150 Confidence Level: 4 AUTHORS: PMID:15161861,PMID:8449405 NOTES:NJ
is described by: ECO:0000269
reversible: false
fast: false
reactant: MODEL1310110055#
is: SBO:0000176

metaR AG13T3g
product: MODEL1310110055#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110055#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110055#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaM bhb m
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:10983
name: (R)-3-hydroxybutyrate
is: HMDB00011
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
initial concentration: 1.0
constant: false

metaM HC02180 e
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
name: thromboxane-b2
initial amount: NaN
is: CHEBI:28728
boundary condition: false
has only substance units: false

metaR 5ADTSTSTERONESte
type: Reaction
name: sulfonated testosterone transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
fast: false
reactant: MODEL1310110055#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110055#
product: MODEL1310110055#

metaM HC00591 c
has only substance units: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
name: 2-oxoglutaramate
constant: false
type: Species
is: CHEBI:16769
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR CHSTEROLt1
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
kinetic law: MODEL1310110055#
fast: false
product: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
is described by: ECO:0000304
reversible: true
is: SBO:0000185
name: cholesterol intracellular transport

metaR r1014
is: SBO:0000185
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110055#
name: Postulated transport reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_f393a8a4_303a_4a20_b39d_c560d8b0dee3
name: ATP5G3
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:518
boundary condition: true
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaR r0178
kinetic law: MODEL1310110055#
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.5.1.21
type: Reaction
is: SBO:0000176
reversible: true
product: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaM thmmp e
name: thiamine(1+) monophosphate(2-)
notes: FORMULA: C12H16N4O4PS CHARGE: -1 INCHI: InChI=1S/C12H17N4O4PS/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19)/p-1 EHMN_ABBREVIATION: C01081
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB02666
is: CHEBI:37575
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_275fe901_fdfc_4e11_b6ee_d3ae1dfda688
boundary condition: true
constant: false
is: SBO:0000252
name: B4GALT2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8704
initial amount: NaN
type: Species

metaM ump e
is: CHEBI:57865
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
name: UMP(2-)
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288

metaR C3DCe
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of malonyl carnitine into extra cellular space
type: Reaction

metaM b2coa m
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:57332
name: crotonoyl-CoA(4-)
is: SBO:0000247
is: HMDB02009
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877

http://identifiers.org/biomodels.db/MODEL1310110055#_c6fb1cad_7eab_45d2_8a81_1b231e95f631
is: Q13423
initial amount: NaN
name: NNT
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:23530
is: SBO:0000252
constant: false
initial concentration: NaN

metaM f1a g
type: Species
initial concentration: 1.0
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: SBO:0000247
name: F1alpha
is: CHEBI:17151
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB02917
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_ec48d81a_2116_44db_94a2_74b293170b4c
is encoded by: hsa:R33828
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
type: Species
name: _R33828_1_c
initial amount: NaN

metaR CHSTEROLt2
is: SBO:0000185
name: cholesterol intracellular transport
type: Reaction
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: true
fast: false
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_2de7bd6b_bb3a_4033_a3a9_ea92d5f35878
boundary condition: true
initial concentration: NaN
type: Species
name: FTCD
is encoded by: hsa:10841
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN

metaM mpdol L c
type: Species
is: SBO:0000247
boundary condition: false
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C1300H2128N20O220P20 CHARGE: -20 INCHI: InChI=1S/C47H82N2O22P2/c1-26(2)13-9-14-27(3)15-10-16-28(4)17-11-18-29(5)19-12-20-30(6)21-22-64-72(60,61)71-73(62,63)70-46-37(49-32(8)54)40(57)43(35(25-52)67-46)68-45-36(48-31(7)53)39(56)44(34(24-51)66-45)69-47-42(59)41(58)38(55)33(23-50)65-47/h13,15,17,19,30,33-47,50-52,55-59H,9-12,14,16,18,20-25H2,1-8H3,(H,48,53)(H,49,54)(H,60,61)(H,62,63)/b27-15+,28-17+,29-19+/t30?,33-,34-,35-,36-,37-,38-,39-,40-,41+,42+,43-,44-,45+,46-,47+/m1/s1
is: CHEBI:18396
initial concentration: 1.0

metaR CHSTEROLt3
name: cholesterol intracellular transport
reactant: MODEL1310110055#
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_aebe6f47_cf34_4436_94e8_1cad1d05c0d7
is encoded by: hsa:376497
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: SLC27A1
has only substance units: false
is: SBO:0000252
type: Species
is: Q6PCB7
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_5d6e6b11_6b62_4db0_abe3_228d833a94f6
is encoded by: hsa:112724
boundary condition: true
constant: false
is: SBO:0000252
is: B3KVA3
has only substance units: false
initial concentration: NaN
type: Species
name: RDH13
initial amount: NaN

metaM HC02180 c
is: SBO:0000247
initial amount: NaN
name: thromboxane-b2
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:28728
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
constant: false
type: Species

metaR BTNt2
name: Biotin reversible transport via proton symport
modifier: MODEL1310110055#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
product: MODEL1310110055#
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110055#

metaM bilirub c
initial amount: NaN
boundary condition: false
name: bilirubin(2-)
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
type: Species
constant: false
is: CHEBI:57977
is: HMDB00054

metaM ump g
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
name: UMP(2-)
type: Species
is: HMDB00288
initial concentration: 1.0
is: CHEBI:57865
is: SBO:0000247

metaM thmmp c
constant: false
name: Thiamin monophosphate
is: SBO:0000247
is: C01081
is: CHEBI:37575
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
is: HMDB02666
boundary condition: false

metaR NAHCO3 HCLt
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
fast: false
name: bicarbonate transport (HCl/NaHCO3 exchange)
reversible: true

metaR r1106
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Postulated transport reaction
kinetic law: MODEL1310110055#
reversible: true
reactant: MODEL1310110055#

metaM biliverd c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57991
is: HMDB01008
type: Species
name: biliverdin(2-)
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
has only substance units: false

metaR SEBACIDTD
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacic acid into cytosol (diffusion)
type: Reaction

metaR GALtly
kinetic law: MODEL1310110055#
name: galactose efflux from lysosome
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reactant: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_5236439a_07a2_4c37_908d_af9e59380f9a
constant: false
is: Q9HBH5
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: RDH14
is encoded by: hsa:57665
type: Species
boundary condition: true

metaR B3GNT31g
product: MODEL1310110055#
is: SBO:0000176
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
fast: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110055#
reversible: false
is described by: ECO:0000269
type: Reaction

metaR RE1525M
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1525
product: MODEL1310110055#
type: Reaction
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110055#_metaM_acgalfuc12gal14acglcgalgluside_hs_g
notes: FORMULA: C58H102N3O31FULLRCO CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
is: CHEBI:57847
is: HMDB00304
initial amount: NaN
is: SBO:0000247

metaM mgacpail hs r
initial concentration: 1.0
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
is: HMDB00220
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:7896
is: SBO:0000247
is: C00249
boundary condition: false
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)

http://identifiers.org/biomodels.db/MODEL1310110055#_74c3dd4c_8e70_4d85_bc35_f6e19d51cb83
is: SBO:0000252
constant: false
initial concentration: NaN
name: GBA
initial amount: NaN
has only substance units: false
is encoded by: hsa:2629
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_18b0afc9_720c_486a_9436_0bedc7db0372
has only substance units: false
type: Species
is encoded by: hsa:4731
is: P56181
boundary condition: true
name: NDUFV3
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN

metaM crm hs c
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: N-acylsphingosine
constant: false
is: CHEBI:52639
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195

metaM 4ppcys c
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
has only substance units: false
initial concentration: 1.0
is: CHEBI:59458
constant: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01117
type: Species
is: C04352

http://identifiers.org/biomodels.db/MODEL1310110055#_02adda8d_bf37_4797_9f0e_0a285d8bda8d
is: SBO:0000252
has only substance units: false
is: P22392
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
name: NME2
is encoded by: hsa:4831
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_5cb840d8_7d3e_4be5_bcab_3c9031d5efd5
is: Q6FGA0
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9167
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: COX7A2L

metaR KSII CORE2tly
name: keratan sulfate II (core 2) transport, extracellular to lysosome
reactant: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110055#

metaR r1010
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
product: MODEL1310110055#
reactant: MODEL1310110055#
name: Postulated transport reaction
type: Reaction
reversible: true
kinetic law: MODEL1310110055#
is described by: ECO:0000000
is: SBO:0000185

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaM pheme c
initial amount: NaN
name: Protoheme
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
initial concentration: 1.0
is: HMDB03178
is: C00032
is: SBO:0000247
constant: false
is: CHEBI:17627

http://identifiers.org/biomodels.db/MODEL1310110055#_e3615160_2994_4cab_83a4_a44041870d66
type: Species
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: _AI656480_1_m
is encoded by: hsa:AI656480

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_a9b078ff_eb5f_43ba_adf3_73f3fcefdbc9
is encoded by: hsa:23236
name: PLCB1
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252

metaR PPPG9tm
reactant: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:14623258 NOTES:NCD. Benzodiazepine receptor PBR see also 17168567
name: protoporphyrinogen IX mitochondrial transport
kinetic law: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
reversible: true
is: SBO:0000185
fast: false

metaR CYOOm3
modifier: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.9.3.1
is: SBO:0000185
reversible: false
product: MODEL1310110055#
name: cytochrome c oxidase, mitochondrial Complex IV
kinetic law: MODEL1310110055#

metaR r1011
reversible: false
product: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
reactant: MODEL1310110055#
name: Transport reaction
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_396e919d_b50e_4faf_8b8b_85d8c272828e
constant: false
is encoded by: hsa:2745
boundary condition: true
type: Species
is: P35754
name: GLRX
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR r1544
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110055#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_2904fc56_64f8_4e0b_818f_f61f0368ef93
constant: false
is: Q9NYW8
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:57786
boundary condition: true
initial concentration: NaN
name: RBAK
type: Species

metaM tymsf e
is: HMDB06409
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
name: Tyramine O-sulfate
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_94e51be3_ec92_4fc1_95d7_6562c60975eb
initial amount: NaN
name: NDUFA7
is: Q6FG42
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:4701
has only substance units: false

metaM ump c
is: C00105
constant: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: CHEBI:57865
name: UMP
initial concentration: 1.0
has only substance units: false
is: HMDB00288
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_bc872591_6216_4380_9c4b_a1694437c84d
name: SOD2
has only substance units: false
boundary condition: true
is encoded by: hsa:6648
is: P04179
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_c59499ba_9e3b_4092_95f6_b960e06ab22a
constant: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:AA177072
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: _AA177072_1_c

metaR RE1518M
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.13
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110055#
name: RE1518
is: SBO:0000176
type: Reaction
product: MODEL1310110055#
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_e33e1c65_1c5b_4a55_8802_037eb640c66a
name: ADH4
boundary condition: true
is encoded by: hsa:127
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is: P08319

http://identifiers.org/biomodels.db/MODEL1310110055#_d68b3cd3_e093_420d_a8ff_78ae61cb3b94
is encoded by: hsa:3033
name: HADH
initial concentration: NaN
has only substance units: false
constant: false
is: Q16836
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM thcrm hs g
type: Species
name: trihexosyl ceramide
initial amount: NaN
is: CHEBI:24636
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110055#_8d8e18cf_b3f9_4d02_9234_f17b308cba88
name: LOXL2
is: SBO:0000252
is: Q9Y4K0
constant: false
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4017

metaR r1012
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
product: MODEL1310110055#
reversible: false
fast: false
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
name: Postulated transport reaction
is: SBO:0000185

metaR PLA2 2
reversible: false
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (8398.1) or (5320.1) or (8398.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:9272153,PMID:9417066 NOTES:phosphatidyl choline degradation NJ
is described by: ECO:0000000
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.1.1.4
fast: false
name: phospholipase A2
is: SBO:0000176
type: Reaction
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_e6a9970e_c722_4508_8e58_2e2498670663
boundary condition: true
has only substance units: false
is encoded by: hsa:160851
constant: false
initial amount: NaN
is: SBO:0000252
is: A8K0I1
type: Species
name: DGKH
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_71260632_53aa_4574_b67a_cdd1e9b70be0
is encoded by: hsa:2678
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is: P19440
constant: false
name: GGT1
initial concentration: NaN
initial amount: NaN

metaM pheme e
initial amount: NaN
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
type: Species
is: CHEBI:17627
initial concentration: 1.0
constant: false
is: HMDB03178
is: C00032
is: SBO:0000247
has only substance units: false
boundary condition: false
name: Protoheme

metaR MTAP
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4507.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.4.2.28 Confidence Level: 4 AUTHORS: PMID:16000004,PMID:2543672,PMID:3091600 NOTES:
product: MODEL1310110055#
name: 5'-methylthioadenosine phosphorylase
modifier: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.28
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_cfb8873a_c807_4fc8_9c65_1d785cdb21a0
is: Q9NYR8
initial amount: NaN
name: RDH8
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:50700
constant: false
is: SBO:0000252

metaM bhb c
type: Species
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
boundary condition: false
name: (R)-3-hydroxybutyrate
constant: false
has only substance units: false
is: HMDB00011
is: CHEBI:10983
initial amount: NaN
is: SBO:0000247

metaR NAGA2ly
modifier: MODEL1310110055#
reversible: false
is: SBO:0000176
name: N-acetylgalactosaminidase, alpha-
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
is described by: ECO:0000000
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.49
product: MODEL1310110055#
fast: false
type: Reaction

metaM dadp m
is: HMDB01508
has only substance units: false
constant: false
is: CHEBI:57667
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: dADP(3-)
boundary condition: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
type: Species

metaR RE2814R
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
name: RE2814
is: SBO:0000176
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110055#
product: MODEL1310110055#
kinetic law: MODEL1310110055#

metaM dadp n
is: CHEBI:57667
type: Species
constant: false
is: HMDB01508
has only substance units: false
name: dADP(3-)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
boundary condition: false
initial concentration: 1.0

metaR r0179
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.1.1.27
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110055#
type: Reaction
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
fast: false
is: SBO:0000176
reactant: MODEL1310110055#

metaR r1013
fast: false
product: MODEL1310110055#
reactant: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
name: Transport reaction
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_2fdbfd26_3400_4111_916f_7c29de627a5d
type: Species
is encoded by: hsa:4594
initial amount: NaN
is: P22033
initial concentration: NaN
is: SBO:0000252
name: MUT
constant: false
has only substance units: false
boundary condition: true

metaR r1546
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110055#
reversible: true
reactant: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110055#
type: Reaction

metaM ametam c
is: HMDB00988
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:57443
type: Species
boundary condition: false
name: S-Adenosylmethioninamine
has only substance units: false
is: SBO:0000247
is: C01137

metaM acmanap c
constant: false
type: Species
initial amount: NaN
name: N-acetyl-D-mannosamine 6-phosphate(2-)
boundary condition: false
is: CHEBI:58557
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H2,15,16,17)/p-2 HEPATONET_1.0_ABBREVIATION: HC01257 EHMN_ABBREVIATION: C04257
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB01121

metaR GCC2cm
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/2.1.2.10
name: glycine-cleavage complex (lipoamide), mitochondrial
type: Reaction
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.4.4.2
product: MODEL1310110055#
reversible: true
kinetic law: MODEL1310110055#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110055#_5b985309_7bf5_43dd_94ca_0ea0e529ea19
is encoded by: hsa:2203
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial amount: NaN
name: FBP1
has only substance units: false
initial concentration: NaN
is: Q2TU34

metaM crm hs g
constant: false
name: N-acylsphingosine
is: CHEBI:52639
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: SBO:0000247

metaR GALASE15ly
fast: false
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
type: Reaction

metaR SQLEr
product: MODEL1310110055#
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
name: Squalene epoxidase, endoplasmic reticular (NADP)
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
is described by: ECO:0000134
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.14.13.132
reversible: false
is: SBO:0000176
type: Reaction
fast: false

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR HGNTOR
is described by: ECO:0000269
kinetic law: MODEL1310110055#
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.5
reactant: MODEL1310110055#
modifier: MODEL1310110055#
reversible: false
product: MODEL1310110055#

metaR SACCD4m
fast: false
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.10 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
kinetic law: MODEL1310110055#
is described by: ECO:0000269
modifier: MODEL1310110055#
reactant: MODEL1310110055#
name: saccharopine dehydrogenase (NAD, L-glutamate forming), mitochondrial
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.5.1.8

http://identifiers.org/biomodels.db/MODEL1310110055#_1830890d_cbb5_4260_9f3f_f0a9a7978276
boundary condition: true
is: P11310
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: ACADM
has only substance units: false
is encoded by: hsa:34
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_c8f3bdbd_758d_4644_b8bf_d882c84a29d3
boundary condition: true
name: PLA2G12A
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:81579
type: Species
is: Q542Y6

metaR GLCt1r
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
type: Reaction
product: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000269
name: glucose transport (uniport)
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
is: SBO:0000185
fast: false

metaR r1547
kinetic law: MODEL1310110055#
reversible: true
reactant: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR PAIL45P HStn
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
is: SBO:0000185
product: MODEL1310110055#
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: true
type: Reaction

metaM bhb e
has only substance units: false
boundary condition: false
is: CHEBI:10983
type: Species
is: SBO:0000247
is: HMDB00011
initial concentration: 1.0
name: (R)-3-hydroxybutyrate
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
constant: false

metaM gam c
boundary condition: false
is: C00329
initial concentration: 1.0
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
has only substance units: false
is: SBO:0000247
constant: false
name: D-Glucosamine
initial amount: NaN
type: Species
is: CHEBI:17315
is: HMDB01514

metaM 3hodcoa m
boundary condition: false
type: Species
constant: false
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
has only substance units: false
name: (S)-3-Hydroxyoctadecanoyl-CoA
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5280355

metaR OCD11COACPT1
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR PRPNCOAHYDm
is version of: http://identifiers.org/ec-code/4.2.1.18
reversible: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
product: MODEL1310110055#
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000176
name: Propenoyl-CoA hydrolase (m)
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110055#_203b6826_6c7b_4c81_9c85_4f980214f947
boundary condition: true
is encoded by: hsa:LOC727762
initial amount: NaN
name: _LOC727762_1_m
constant: false
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN

metaR r1548
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110055#
is described by: ECO:0000000
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_8b01b3c0_a371_49f6_a336_acfb343dfcdb
initial amount: NaN
name: GCSH
boundary condition: true
type: Species
is: P23434
is encoded by: hsa:2653
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR DGK2m
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.8 Confidence Level: 2 AUTHORS: NOTES:Added EC- JLR IT
reactant: MODEL1310110055#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110055#
is: SBO:0000176
reversible: true
product: MODEL1310110055#
name: deoxyguanylate kinase (dGMP:dATP) (mitochondrial)

http://identifiers.org/biomodels.db/MODEL1310110055#_da30a68e_ad49_4d43_bb1a_e10315e1729b
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: SUCLG1
constant: false
is encoded by: hsa:8802
has only substance units: false
is: P53597

http://identifiers.org/biomodels.db/MODEL1310110055#_05bd01b1_6c2f_4256_a4d2_768f196e6f13
is encoded by: hsa:10201
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: NME6
is: O75414

metaM crm hs e
is: CHEBI:52639
name: N-acylsphingosine
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195

metaR IDOURte
type: Reaction
product: MODEL1310110055#
reversible: true
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
name: L-iduronate transport, extracellular
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#

metaR GALASE19ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110055#
is: SBO:0000176
modifier: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000269
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.1.6.4

http://identifiers.org/biomodels.db/MODEL1310110055#_e13ba37c_e2de_450b_a0b5_b1c98346f709
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI990637
initial amount: NaN
name: _AI990637_1_x
is: SBO:0000252
type: Species

metaR O2ter
type: Reaction
name: O2 transport, endoplasmic reticulum
reversible: true
is: SBO:0000185
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaM ppi x
is: HMDB00250
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
is: C00013
initial amount: NaN
is: CHEBI:33019
type: Species
initial concentration: 1.0
name: Diphosphate
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013

http://identifiers.org/biomodels.db/MODEL1310110055#_485d66bb_bc4f_4093_b83b_16eeb9ad5190
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
name: PLCZ1
is encoded by: hsa:89869
boundary condition: true
is: SBO:0000252
is: Q86YW0

metaR r1549
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110055#
type: Reaction
reversible: true
kinetic law: MODEL1310110055#
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR MI14PP
is version of: http://identifiers.org/ec-code/3.1.3.57
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000176
modifier: MODEL1310110055#
name: inositol-1,4-bisphosphate 1-phosphatase
fast: false
type: Reaction
reversible: false
product: MODEL1310110055#
is described by: ECO:0000269

metaR PROt4 2 r
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
kinetic law: MODEL1310110055#
is described by: ECO:0000006
type: Reaction
reversible: true
fast: false
name: Proline transport (sodium symport) (2:1)
modifier: MODEL1310110055#
reactant: MODEL1310110055#
product: MODEL1310110055#

metaR RE1233C
is described by: ECO:0000000
reactant: MODEL1310110055#
name: RE1233
type: Reaction
is: SBO:0000176
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.6.1.64
fast: false
reversible: true

metaR MI1PP
reactant: MODEL1310110055#
fast: false
is described by: ECO:0000269
product: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
name: myo-inositol 1-phosphatase
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.25
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_c6a91547_d281_47c3_bcdd_76b388011b7c
has only substance units: false
name: ALDH1B1
is: P30837
is: SBO:0000252
is encoded by: hsa:219
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
boundary condition: true

metaR MTHFDm
reversible: true
type: Reaction
modifier: MODEL1310110055#
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/6.3.4.3
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.9
product: MODEL1310110055#
is: SBO:0000176

metaM gam e
is: C00329
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
constant: false
has only substance units: false
initial amount: NaN
is: HMDB01514
is: CHEBI:17315
name: D-Glucosamine
type: Species

metaR EX doco13ac
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

metaR FAOXC15ATPx
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C15)x
type: Reaction

metaR CYTK10n
type: Reaction
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000269
name: cytidylate kinase (CMP,dGTP),nuclear
fast: false
reactant: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reversible: true

metaR r0399
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110055#
modifier: MODEL1310110055#
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000176
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
is version of: http://identifiers.org/ec-code/1.2.4.2
fast: false
reversible: true

metaR r0741
modifier: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
is: SBO:0000176
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
is described by: ECO:0000000
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false

metaM hs deg21 l
type: Species
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
notes: FORMULA: C37H55NO38S2 CHARGE: -4
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:16126

http://identifiers.org/biomodels.db/MODEL1310110055#_9d2a3271_28fe_4f32_b24b_25bbfb472490
type: Species
name: PPAP2A
initial concentration: NaN
is: SBO:0000252
is: G3XA95
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:8611
boundary condition: true

metaM prostge1 e
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin E1(1-)
is: HMDB01442
type: Species
initial amount: NaN
is: CHEBI:57397
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
constant: false
has only substance units: false
boundary condition: false

metaR PUNP3
modifier: MODEL1310110055#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
product: MODEL1310110055#
is described by: ECO:0000269
is: SBO:0000176
name: purine-nucleoside phosphorylase (Guanosine)
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_bedc7f84_9330_4d26_a2dd_8e9523bf8228
is: B4DER4
boundary condition: true
name: PIK3CB
is encoded by: hsa:5291
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false

metaR XOL7AONEtr
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000000
fast: false
name: lipid, flip-flop intracellular transport
is: SBO:0000185
product: MODEL1310110055#
reversible: true

metaM hpdcacoa m
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
constant: false
is: HMDB06497
has only substance units: false
name: heptadecanoyl coa
initial amount: NaN

metaR OCDCEAtr
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110055#
name: fatty acid transport via diffusion
is: SBO:0000185
kinetic law: MODEL1310110055#
fast: false
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110055#_81a2e493_56eb_49e5_9e4b_604cb2abecf3
initial concentration: NaN
is: B4DX62
is: SBO:0000252
is encoded by: hsa:6487
constant: false
has only substance units: false
type: Species
boundary condition: true
name: ST3GAL3
initial amount: NaN

metaR RE2814M
name: RE2814
kinetic law: MODEL1310110055#
type: Reaction
reversible: true
reactant: MODEL1310110055#
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
product: MODEL1310110055#

metaR PUNP2
is: SBO:0000176
fast: false
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
modifier: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110055#
type: Reaction
name: purine-nucleoside phosphorylase (Deoxyadenosine)

metaM thf e
initial concentration: 1.0
is: HMDB01846
constant: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: CHEBI:57453
is: SBO:0000247
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false

metaR FRDPtr
kinetic law: MODEL1310110055#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110055#
type: Reaction
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ

metaM adn c
is: C00212
has only substance units: false
type: Species
name: Adenosine
is: SBO:0000247
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
initial concentration: 1.0
is: HMDB00050
constant: false
initial amount: NaN
is: CHEBI:16335
boundary condition: false

metaM pglyc hs c
type: Species
is: SBO:0000247
name: pglyc_hs[c]
is: HMDB02704
initial concentration: 1.0
is: CHEBI:21338
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: CHARGE: 0

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaM succoa c
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
type: Species
is: HMDB01022
initial concentration: 1.0
name: Succinyl-CoA
is: SBO:0000247

metaR r1761
modifier: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110055#
product: MODEL1310110055#
fast: false

metaR r0630
product: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.2
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110055#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.1
type: Reaction
reactant: MODEL1310110055#

metaR r0743
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
is described by: ECO:0000000
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
fast: false

metaR PUNP1
name: purine-nucleoside phosphorylase (Adenosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reactant: MODEL1310110055#
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false
kinetic law: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110055#_8649609c_0805_4f8f_a64f_8281193321f9
is encoded by: hsa:23600
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: AMACR
is: Q3KT79

http://identifiers.org/biomodels.db/MODEL1310110055#_5396110d_afc7_49b2_b797_288b09a79cbb
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: P51178
name: PLCD1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5333

metaM dcholcoa x
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: HMDB06292
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:28701
has only substance units: false
name: chenodeoxycholoyl coenzyme a
is: SBO:0000247

metaR EX c16dc
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecanedioic acid mono-L-carnitine ester
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_c02460c2_2449_431a_9ea4_5ad1a52eb47e
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is: O43677
name: NDUFC1
is encoded by: hsa:4717
is: SBO:0000252

metaR S6T1g
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000176

metaM dodecanac c
is: HMDB00623
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
name: Dodecanedioic acid
boundary condition: false
notes: FORMULA: C12H20O4 CHARGE: -2
type: Species

metaR G14T11g
fast: false
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: false
product: MODEL1310110055#
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000

metaM c8dc c
is: HMDB00791
is: SBO:0000247
constant: false
type: Species
name: suberyl carnitine
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C15H26NO6 CHARGE: -1
is: C02838

metaR EX vacc LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: vaccenic acid exchange
type: Reaction

metaR r0744
fast: false
kinetic law: MODEL1310110055#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
reactant: MODEL1310110055#
type: Reaction
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110055#

metaR GLNtN1
is: SBO:0000185
reactant: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269
modifier: MODEL1310110055#
fast: false
name: Glutamine transport (Na, H coupled)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_054c7d6e_5193_420a_9c46_fb4f72f58467
has only substance units: false
name: _H53099_1_m
initial concentration: NaN
is encoded by: hsa:H53099
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true

metaM thf c
initial concentration: 1.0
is: HMDB01846
constant: false
is: CHEBI:57453
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
boundary condition: false
is: C00101
name: 5,6,7,8-Tetrahydrofolate

metaR ACNACNGALGBSIDEtg
is described by: ECO:0000000
product: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reversible: true
is: SBO:0000185
name: acnacngalgbside hs intracellular transport
reactant: MODEL1310110055#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_146165cf_ab16_49af_b8ff_d1abeea66100
name: SLC26A2
is encoded by: hsa:1836
initial amount: NaN
is: SBO:0000252
type: Species
is: P50443
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_7fed77ac_c4da_47fb_9fcb_7aef5a25bf4c
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3030
is: E9KL44
name: HADHA
initial amount: NaN
boundary condition: true

metaM adn e
is: C00212
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00050
constant: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
name: Adenosine
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16335
boundary condition: false

metaR LEUGLYPEPT1tc
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaM pglyc hs e
constant: false
name: phosphatidylglycerol(1-)
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:60523
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096

http://identifiers.org/biomodels.db/MODEL1310110055#_f4a8ebdf_68b6_4a37_915a_572bf64bf906
is: SBO:0000252
is: P23919
initial amount: NaN
name: DTYMK
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:1841
initial concentration: NaN
type: Species

metaM dcholcoa r
type: Species
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: CHEBI:28701
has only substance units: false
name: chenodeoxycholoyl coenzyme a
initial amount: NaN
is: HMDB06292
initial concentration: 1.0

metaM xol27oh m
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: HMDB02103
initial concentration: 1.0
is: SBO:0000247
name: 26-hydroxycholesterol
is: CHEBI:17703
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_4ab96f43_9259_4e14_a192_c20aac5b6661
is: Q9BV79
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
constant: false
is encoded by: hsa:51102
name: MECR
initial amount: NaN
initial concentration: NaN

metaR PUNP7
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
reactant: MODEL1310110055#
name: purine-nucleoside phosphorylase (Xanthosine)
modifier: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110055#
is: SBO:0000176
product: MODEL1310110055#
fast: false
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_cbe7334c_5976_4557_884c_8ae429f806fd
initial amount: NaN
is: Q5FC00
name: CA6
is encoded by: hsa:765
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species

metaR r1552
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM k e
type: Species
name: potassium
has only substance units: false
boundary condition: false
is: CHEBI:29103
is: HMDB00586
initial concentration: 1.0
constant: false
initial amount: NaN
is: C00238
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_61bea3cb_fe2a_44f5_a0a3_b7caaa6da113
is encoded by: hsa:521
type: Species
initial concentration: NaN
is: P56385
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: ATP5I
boundary condition: true

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR PEPCKm
fast: false
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.1.1.32
type: Reaction
product: MODEL1310110055#
is: SBO:0000176
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
name: Phosphoenolpyruvate carboxykinase (GTP)
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:

metaR FAOXC16DCr
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

metaR ADPACTD
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport into cytosol (diffusion)
type: Reaction

metaR C142CPT1
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecadienoylcarnitine
type: Reaction

metaR ACNACNGALGBSIDEte
reactant: MODEL1310110055#
name: acnacngalgbside hs transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
product: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
reversible: true
type: Reaction
is: SBO:0000185

metaM 5forthf c
type: Species
is: CHEBI:57456
is: SBO:0000247
initial amount: NaN
is: C00664
is: HMDB01534
initial concentration: 1.0
constant: false
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
has only substance units: false
name: 5-Formiminotetrahydrofolate
boundary condition: false

metaR PUNP6
reversible: true
kinetic law: MODEL1310110055#
product: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is described by: ECO:0000269
modifier: MODEL1310110055#
type: Reaction
name: purine-nucleoside phosphorylase (Deoxyinosine)
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110055#
is: SBO:0000176

metaR PIter
name: phosphate transport, endoplasmic reticulum
type: Reaction
is: SBO:0000185
modifier: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
reversible: true
kinetic law: MODEL1310110055#
fast: false
is described by: ECO:0000212

metaR r1765
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is: SBO:0000185
product: MODEL1310110055#
reactant: MODEL1310110055#
modifier: MODEL1310110055#
name: Y+LAT2 Utilized transport
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110055#

metaR URAt
reactant: MODEL1310110055#
is: SBO:0000185
kinetic law: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
is described by: ECO:0000269
product: MODEL1310110055#
fast: false
name: uracil transport via facilated diffusion
reversible: true

metaM dnad c
is: HMDB01179
initial amount: NaN
is: CHEBI:18304
is: SBO:0000247
type: Species
is: C00857
initial concentration: 1.0
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
boundary condition: false
constant: false
name: Deamino-NAD+
has only substance units: false

metaM ksi deg21 l
name: keratan sulfate I, degradation product 21
is: SBO:0000247
has only substance units: false
is: CHEBI:12936
boundary condition: false
constant: false
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
is: HMDB00143
type: Species
initial amount: NaN
initial concentration: 1.0

metaR r1551
reversible: true
reactant: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110055#
fast: false
product: MODEL1310110055#
is: SBO:0000185

metaM ksi deg6 l
has only substance units: false
name: keratan sulfate I, degradation product 6
constant: false
boundary condition: false
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
initial concentration: 1.0
initial amount: NaN
is: CHEBI:12936
is: HMDB00143
type: Species
is: SBO:0000247

metaR DAG HSter
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: diacylglycerol ER export
kinetic law: MODEL1310110055#
reversible: false
reactant: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaM tymsf c
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
is: HMDB06409
is: SBO:0000247
name: Tyramine O-sulfate
boundary condition: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_73ccc5e9_e01e_4bf3_bba1_bdd091bd952e
has part: B4DY56
is: SBO:0000297
has only substance units: false
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is encoded by: hsa:498
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_b6f92f74_fc65_4306_8f73_cef1e1e2da03
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: P57054
type: Species
boundary condition: true
name: PIGP
is encoded by: hsa:51227
initial concentration: NaN
constant: false

metaM prostge1 c
is: SBO:0000247
is: HMDB01442
name: prostaglandin E1(1-)
is: CHEBI:57397
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
boundary condition: false
constant: false
initial concentration: 1.0

metaR INSTt4
is: SBO:0000185
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
modifier: MODEL1310110055#
reversible: true
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
name: inositol transport via sodium symport
fast: false
is described by: ECO:0000269
type: Reaction

metaR P45011A1m
fast: false
kinetic law: MODEL1310110055#
name: Cytochrome P450 11A1, mitochondrial [Precursor]
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.14.15.6
modifier: MODEL1310110055#
reversible: false
notes: GENE_ASSOCIATION: (1583.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.15.67 Confidence Level: 4 AUTHORS: PMID:16232916 NOTES:reaction sequence mx steps, grouped into single reaction uses adrenal ferredoxin NJ
product: MODEL1310110055#
type: Reaction

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_347b00cf_1426_402e_9fea_cde6d70e1bf5
name: PIGA
is encoded by: hsa:5277
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true

metaR PPA
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
kinetic law: MODEL1310110055#
name: inorganic diphosphatase
reactant: MODEL1310110055#
is: SBO:0000176
modifier: MODEL1310110055#
is described by: ECO:0000269
fast: false
product: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.1
reversible: false

metaR ACOAO7p
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
reversible: false
reactant: MODEL1310110055#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
is: SBO:0000176
modifier: MODEL1310110055#

metaR PUNP5
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
modifier: MODEL1310110055#
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110055#
type: Reaction
product: MODEL1310110055#
reversible: true
is: SBO:0000176
fast: false
name: purine-nucleoside phosphorylase (Inosine)
is described by: ECO:0000269

metaR r0747
product: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is: SBO:0000176
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
is described by: ECO:0000000
reversible: true

metaR r1554
reactant: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_50393ad6_8c83_413d_b5d2_1bace0cf1118
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:6392
boundary condition: true
name: SDHD
type: Species
initial amount: NaN
is: O14521

http://identifiers.org/biomodels.db/MODEL1310110055#_3822be65_a5bf_48a2_8438_0b873325ffb4
initial concentration: NaN
constant: false
is encoded by: hsa:518
is: SBO:0000297
has part: P48201
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
boundary condition: true
has only substance units: false
type: Species

metaM hs deg3 l
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
name: heparan sulfate, degradation product 3
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
is: SBO:0000247
is: CHEBI:16126
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_82b16294_94d7_4be0_869d_fc96e1a73c87
has only substance units: false
name: SLC40A1
is encoded by: hsa:30061
type: Species
boundary condition: true
initial amount: NaN
is: Q9NP59
is: SBO:0000252
constant: false
initial concentration: NaN

metaM dudp n
is: HMDB01000
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: CHEBI:60471
initial amount: NaN
is: SBO:0000247
name: dUDP(3-)
boundary condition: false

metaM pmtcoa c
boundary condition: false
constant: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: C00154
type: Species
is: CHEBI:3454
is: SBO:0000247
is: HMDB01338
name: Palmitoyl-CoA (n-C16:0CoA)
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR HOCTDACBP
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyoctadecenoylcoa from mitochondria into the cytosol
type: Reaction

metaM lnlncacrn c
name: alpha-linolenyl carnitine
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB06319
boundary condition: false
constant: false
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1

metaM k c
is: SBO:0000247
has only substance units: false
name: potassium
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:29103
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: HMDB00586
constant: false
initial amount: NaN
is: C00238

metaR CMPSASn
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.7.43
modifier: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000304
reversible: false
fast: false
name: CMP sialic acid synthase, nuclear

http://identifiers.org/biomodels.db/MODEL1310110055#_2ba3a1ca_ecaa_4016_8b05_1baaa6fbacb0
name: AMPD1
is: P23109
constant: false
is encoded by: hsa:270
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true

metaM cspg e l
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
is: HMDB02183
constant: false
type: Species
has only substance units: false
is: CHEBI:36005
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR PUNP4
kinetic law: MODEL1310110055#
is: SBO:0000176
reversible: true
product: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Deoxyguanosine)
type: Reaction
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_ba8da649_80e9_423a_b9ef_54cdb7abb5fa
constant: false
boundary condition: true
type: Species
has only substance units: false
is: P07203
is: SBO:0000252
is encoded by: hsa:2876
initial concentration: NaN
name: GPX1
initial amount: NaN

metaR r1553
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110055#
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_2403bbcf_02e1_4c09_a292_2a5b80e775b9
initial concentration: NaN
is encoded by: hsa:8372
is: O43820
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
constant: false
name: HYAL3

metaM CE5126 x
is: CHEBI:12947
initial concentration: 1.0
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5126
initial amount: NaN
name: (2R)-pristanoyl-CoA
constant: false
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_fe651c0d_60c7_422d_887f_b4bf09a20609
type: Species
name: LGSN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:51557
initial amount: NaN
is: Q5TDP6
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_fcaa7abd_4e47_49b4_8948_2df88ecd35c6
boundary condition: true
constant: false
initial concentration: NaN
name: PLCB1
has only substance units: false
is encoded by: hsa:23236
is: Q9NQ66
is: SBO:0000252
type: Species
initial amount: NaN

metaM dudp m
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
type: Species
is: CHEBI:60471
name: dUDP(3-)
is: HMDB01000

metaM C05957 r
is: HMDB02710
is: CHEBI:27485
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
name: Prostaglandin J2
has only substance units: false

metaR EX gly LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Glycine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_01418def_4bd4_4ac8_ba34_cde5100bbad7
type: Species
name: SOD1
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
is: P00441
is encoded by: hsa:6647

metaM 10fthf c
has only substance units: false
is: C00234
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454
boundary condition: false
initial concentration: 1.0
name: 10-Formyltetrahydrofolate
initial amount: NaN
type: Species
is: HMDB00972
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_490fbf9d_9a9c_4c76_aff8_4224bb89fe30
has only substance units: false
constant: false
is encoded by: hsa:23556
initial concentration: NaN
initial amount: NaN
name: PIGN
is: SBO:0000252
type: Species
boundary condition: true

metaM dmpp x
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
boundary condition: false
is: SBO:0000247
is: HMDB01120
name: prenyl diphosphate(3-)
initial amount: NaN
is: CHEBI:57623
initial concentration: 1.0
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_1b398da7_f657_41b0_80de_8964b5b6649f
is encoded by: hsa:5471
is: SBO:0000252
initial concentration: NaN
name: PPAT
is: Q06203
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true

metaR INSTt2r
fast: false
modifier: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
name: inositol transport in via proton symport
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000185
is described by: ECO:0000269
reversible: true

metaR r0391
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
fast: false
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
is described by: ECO:0000000
product: MODEL1310110055#
type: Reaction
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_0c664edc_08af_4220_ad7c_bad1b9ac9f2a
initial amount: NaN
type: Species
has part: B4DP47
boundary condition: true
is encoded by: hsa:1629
has part: P21953
has part: P11182
has only substance units: false
is: SBO:0000297
constant: false
is encoded by: hsa:594
name: DBT:DLD:BCKDHA:BCKDHB
initial concentration: NaN
is encoded by: hsa:593

metaM thcholstoic x
is: SBO:0000247
boundary condition: false
is: CHEBI:18402
constant: false
type: Species
initial concentration: 1.0
is: HMDB03873
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
has only substance units: false
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate

http://identifiers.org/biomodels.db/MODEL1310110055#_d643340e_3d44_47b7_87be_999772a94478
is encoded by: hsa:594
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: DBT:DLD:BCKDHA:BCKDHB
is: SBO:0000297
has part: Q9BQL0
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_19850ea2_e8e3_4014_9ddc_1e491e30d69d
has only substance units: false
boundary condition: true
is: O75874
name: IDH1
is: SBO:0000252
type: Species
is encoded by: hsa:3417
initial amount: NaN
constant: false
initial concentration: NaN

metaR DMATTx
fast: false
type: Reaction
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000176
modifier: MODEL1310110055#
is described by: ECO:0000134
product: MODEL1310110055#
name: dimethylallyltranstransferase
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
is version of: http://identifiers.org/ec-code/2.5.1.1
reversible: false

metaM ethamp c
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:58190
is: SBO:0000247
is: HMDB00224
name: ethamp[c]
constant: false
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_b0c4466b_437d_402f_9ed0_6f8fadae80ec
has only substance units: false
name: PDE7B
is encoded by: hsa:27115
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q9NP56
type: Species

metaM l2fn2m2masn g
notes: FORMULA: C68H113N4O49X CHARGE: 0
initial amount: NaN
has only substance units: false
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
is: CHEBI:28067
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false

metaR UPPN
kinetic law: MODEL1310110055#
name: b-ureidopropionase
product: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
modifier: MODEL1310110055#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.6
reactant: MODEL1310110055#
is: SBO:0000176
is described by: ECO:0000269
fast: false

metaR FOLt2
is described by: ECO:0000269
product: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: (6573.1) or (6573.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:14770311 NOTES:IT
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110055#
name: folate transport via anion exchange
fast: false

metaM ump r
has only substance units: false
is: HMDB00288
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
name: UMP
is: CHEBI:57865
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
type: Species

metaM ksi deg38 l
is: SBO:0000247
initial concentration: 1.0
is: HMDB00143
notes: FORMULA: C54H91N3O41 CHARGE: 0
constant: false
has only substance units: false
is: CHEBI:12936
boundary condition: false
name: keratan sulfate I, degradation product 38
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_cd5ecad9_e9fc_4583_8bc1_1c361ebf7e01
is: Q4KWH8
constant: false
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:23007
name: PLCH1
initial concentration: NaN
initial amount: NaN

metaR GPIAT
name: glucosaminylphosphatidyl inositol acetyltransferase
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
type: Reaction
fast: false
kinetic law: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_922a11d9_ce71_4f6c_acc9_46242090e22b
boundary condition: true
is encoded by: hsa:8733
name: PIGK:PIGU:PIGT:GPAA1:PIGS
is encoded by: hsa:51604
is encoded by: hsa:10026
initial concentration: NaN
has part: Q969N2
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:128869
has part: Q92643
is encoded by: hsa:94005
has part: Q9H490
has part: O43292
type: Species
has part: Q8NBL9
is: SBO:0000297

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaR PLA2 2e
reactant: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reversible: false
product: MODEL1310110055#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.1.4
notes: GENE_ASSOCIATION: (5322.1) or (5319.1) or (81579.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (30814.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:10455175,PMID:10681567,PMID:11031251,PMID:11112443,PMID:8300559,PMID:9188469,PMID:9272153,PMID:9886417 NOTES:phosphatidyl choline degradation NJ
name: phospholipase A2

metaR FAOXC221C201x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

metaR CERT1rt
fast: false
reactant: MODEL1310110055#
type: Reaction
is: SBO:0000185
is described by: ECO:0000304
product: MODEL1310110055#
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
reversible: true
name: ceramide transport protein
is version of: http://identifiers.org/ec-code/2.7.11.1
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_8dc5eb39_c076_4408_80f0_ca7479102828
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: OXSM
constant: false
boundary condition: true
is encoded by: hsa:54995
type: Species
is: Q9NWU1
initial concentration: NaN

metaM L2aadp m
name: L-2-aminoadipate(1-)
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB00510
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: CHEBI:58672
boundary condition: false

metaM hpdcacoa c
type: Species
is: HMDB06497
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
name: heptadecanoyl coa
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110055#_7ec61925_16ca_4bf5_bfa1_e39e6ad6d596
constant: false
has only substance units: false
boundary condition: true
is: Q8TDY1
is encoded by: hsa:8706
initial amount: NaN
type: Species
is: SBO:0000252
name: B3GALNT1
initial concentration: NaN

metaR r0638
is described by: ECO:0000000
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is version of: http://identifiers.org/ec-code/2.8.1.2
fast: false
reversible: true
kinetic law: MODEL1310110055#
product: MODEL1310110055#
modifier: MODEL1310110055#
type: Reaction
is: SBO:0000176

metaR CHLtm
name: choline transport via diffusion (cytosol to mitochondria)
reversible: true
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
fast: false
product: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
is: SBO:0000185

metaR r0390
reactant: MODEL1310110055#
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110055#
product: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
reversible: true

metaR UDPDOLPT L
fast: false
is: SBO:0000176
reversible: false
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
is version of: http://identifiers.org/ec-code/2.4.1.117
modifier: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_0c0e81f2_6a0d_498b_8c0c_795fdbf26d25
has only substance units: false
type: Species
is: SBO:0000252
is: P47895
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: ALDH1A3
is encoded by: hsa:220
constant: false

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaM crm hs r
constant: false
name: N-acylsphingosine
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
type: Species
is: SBO:0000247
is: CHEBI:52639

metaR SERGLNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110055#
fast: false
product: MODEL1310110055#
type: Reaction
name: L-serine/L-glutamine Na-dependent exchange (Ser-L in)
reactant: MODEL1310110055#
modifier: MODEL1310110055#

metaR 4HGLSDm
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
is described by: ECO:0000212
product: MODEL1310110055#
is: SBO:0000176
type: Reaction
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.5.1.12
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
modifier: MODEL1310110055#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_69714306_9ed8_4c8b_bd40_b4e01233ee78
initial concentration: NaN
name: _J03866_1_m
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:J03866
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_0ee54636_0f1a_490f_adb3_302591ce2ae6
is: P14060
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false
name: HSD3B1
is: SBO:0000252
is encoded by: hsa:3283

metaR GLCAASE7ly
kinetic law: MODEL1310110055#
is: SBO:0000176
name: beta-glucuronidase, lysosomal
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.31
reactant: MODEL1310110055#
type: Reaction
reversible: false
product: MODEL1310110055#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_31bf222d_2819_4e3f_ab9b_962b161d1a3a
type: Species
is encoded by: hsa:H45672
is: SBO:0000252
constant: false
name: _H45672_1_m
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_5f4eca29_b4d3_4790_af65_f2fd5e393917
is: P22392
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:4831
name: NME2

metaR FAOXC163C164x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)x
type: Reaction

metaR NDP7g
is version of: http://identifiers.org/ec-code/3.6.1.6
reactant: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
modifier: MODEL1310110055#
name: nucleoside-diphosphatase (UDP), Golgi apparatus
product: MODEL1310110055#
is: SBO:0000176
fast: false
is described by: ECO:0000269
type: Reaction

metaR GALASE16ly
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
product: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR STRDNCt
reversible: true
product: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
name: fatty acid transport via diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110055#
type: Reaction
is: SBO:0000185

metaR CMPSAS
modifier: MODEL1310110055#
name: CMP sialic acid synthase
reactant: MODEL1310110055#
is described by: ECO:0000304
product: MODEL1310110055#
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
reversible: false
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.7.43

metaM arg L e
initial concentration: 1.0
is: HMDB00517
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:32682
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
has only substance units: false
name: L-argininium(1+)

metaR HPACtr
is: SBO:0000185
name: hydroxyphenylacetate transport via diffusion
is described by: ECO:0000000
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
reactant: MODEL1310110055#
fast: false
reversible: true
kinetic law: MODEL1310110055#
type: Reaction

metaR DNDPt15m
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#
is described by: ECO:0000269
kinetic law: MODEL1310110055#
name: dUDP transport via dGDP antiport
is: SBO:0000185
fast: false
product: MODEL1310110055#

metaR TYROXDAc
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000269
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.4.3.4
modifier: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
fast: false
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110055#_11d94745_280a_4f34_bb21_06a4e0022494
name: SLC5A3
is: P53794
is encoded by: hsa:6526
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species

metaM adrn c
initial amount: NaN
is: CHEBI:53487
has only substance units: false
is: SBO:0000247
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
name: adrenic acid
is: HMDB02226
constant: false
boundary condition: false
type: Species
initial concentration: 1.0

metaM hista c
has only substance units: false
is: HMDB00870
initial concentration: 1.0
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
boundary condition: false
initial amount: NaN
is: CHEBI:58432
is: SBO:0000247
name: histamium
constant: false
type: Species

metaM thcholstoic r
initial amount: NaN
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial concentration: 1.0
is: HMDB03873
constant: false
type: Species
is: CHEBI:18402
boundary condition: false
has only substance units: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: SBO:0000247

metaM 3hexdtetcoa x
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: 3,7,10,13-hexadecatetraenoylcoa
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial amount: NaN
is: HMDB02288
has only substance units: false

metaM cspg e e
initial amount: NaN
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
boundary condition: false
is: CHEBI:17568
initial concentration: 1.0
is: C00106
is: HMDB00300
is: SBO:0000247
type: Species
constant: false
has only substance units: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan

metaR OBDHc
name: 2-Oxobutanoate dehydrogenase, cytosolic
type: Reaction
reactant: MODEL1310110055#
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000000
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.7.2 Confidence Level: 2 AUTHORS: NOTES:as shown in Lehninger (4th ed.) for threonine degradation MM

metaR GLCNACASE5ly
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is: SBO:0000176
name: alpha-N-acetylglucosaminidase, lysosomal
type: Reaction
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.50
reactant: MODEL1310110055#
fast: false
is described by: ECO:0000000
product: MODEL1310110055#

metaR r0170
is described by: ECO:0000000
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
reversible: true
modifier: MODEL1310110055#
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.1.40
reactant: MODEL1310110055#
product: MODEL1310110055#

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaM lnlncacrn m
initial amount: NaN
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: HMDB06319
name: alpha-linolenyl carnitine

metaR r0633
fast: false
is described by: ECO:0000000
reversible: true
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.7.3
kinetic law: MODEL1310110055#
type: Reaction
product: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_a8f90706_1200_4d24_b740_48733e495ab0
is: SBO:0000252
is: Q6IBC4
is encoded by: hsa:4726
name: NDUFS6
initial concentration: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
initial amount: NaN

metaM ump n
boundary condition: false
type: Species
constant: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial concentration: 1.0
is: CHEBI:57865
name: UMP(2-)
initial amount: NaN
is: HMDB00288
has only substance units: false
is: SBO:0000247

metaR r0393
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.1.74
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
type: Reaction
is: SBO:0000176
fast: false
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110055#_2e1a4a6e_00c6_471c_8238_53da677d5b25
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: ALDH2
type: Species
is encoded by: hsa:217
is: P05091
constant: false

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR LEUt5m
name: leucine mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is: SBO:0000185
reversible: true
product: MODEL1310110055#
is described by: ECO:0000000
kinetic law: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
type: Reaction

metaR FAOXC143C123x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_d44135b5_475b_4be6_a7a2_867a5b8ff5f5
type: Species
is: F6KD01
is encoded by: hsa:5728
name: PTEN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM arg L c
boundary condition: false
is: HMDB00517
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:32682
has only substance units: false
name: L-argininium(1+)
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial concentration: 1.0

metaM 3docopencoa x
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
constant: false
type: Species
name: 3,7,10,13,16-docosapentenoylcoa

metaR r0634
is: SBO:0000176
reactant: MODEL1310110055#
fast: false
is described by: ECO:0000000
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is version of: http://identifiers.org/ec-code/3.1.4.1
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
product: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
reversible: true

metaR ACGALK2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
name: N-acetylgalactosamine kinase (ITP)
is: SBO:0000176
reactant: MODEL1310110055#
reversible: false
fast: false
product: MODEL1310110055#
kinetic law: MODEL1310110055#

metaR FRDPtc
type: Reaction
kinetic law: MODEL1310110055#
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
is: SBO:0000185
product: MODEL1310110055#
is described by: ECO:0000000
reversible: true

metaR r0394
fast: false
reactant: MODEL1310110055#
is described by: ECO:0000000
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
type: Reaction
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110055#
product: MODEL1310110055#

metaM adrn e
boundary condition: false
is: HMDB02226
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
is: SBO:0000247
name: adrenic acid
is: CHEBI:53487
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaM hista e
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: SBO:0000247
is: CHEBI:58432
constant: false
name: histamium
type: Species
is: HMDB00870

metaR ALOX52
product: MODEL1310110055#
reactant: MODEL1310110055#
modifier: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.34
fast: false
reversible: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110055#
name: Arachidonate 5-lipoxygenase
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764

http://identifiers.org/biomodels.db/MODEL1310110055#_ad55180a_5625_48b3_aa21_2bcc3869fe79
is: B7Z3W8
type: Species
is: SBO:0000252
name: SLC6A9
is encoded by: hsa:6536
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_360fa654_71c4_4d17_aee0_6afdce6ace34
boundary condition: true
name: SLC19A3
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q9BZV2
is encoded by: hsa:80704
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_aeb76eae_2af5_4762_b3cb_604d8d00bc88
is: P36542
is encoded by: hsa:509
constant: false
is: SBO:0000252
name: ATP5C1
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species

metaR RE3218C
fast: false
product: MODEL1310110055#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.2
reactant: MODEL1310110055#
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
name: RE3218
type: Reaction
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton

http://identifiers.org/biomodels.db/MODEL1310110055#_bf5be3be_3e7b_4fff_b683_0e9106d1d155
has part: O00330
has only substance units: false
is encoded by: hsa:4967
has part: P09622
type: Species
boundary condition: true
constant: false
is: SBO:0000297
is encoded by: hsa:1743
is encoded by: hsa:8050
name: DLD:DLST:OGDH:PDHX
has part: Q02218
has part: P36957
initial amount: NaN
is encoded by: hsa:1738
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_82b1de02_d6ac_47a0_be05_e42e64d753fa
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2544
type: Species
name: _2544_1_c
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_39b22f42_2c63_4121_8b13_9a0a5cc65bfb
constant: false
initial concentration: NaN
has only substance units: false
name: _AA021081_1_r
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AA021081

metaR AG13T2g
reversible: false
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000000
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
fast: false
is: SBO:0000176

metaR ILETAm
is version of: http://identifiers.org/ec-code/2.6.1.42
name: isoleucine transaminase, mitochondrial
type: Reaction
modifier: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reactant: MODEL1310110055#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110055#

metaM pmtcoa x
initial concentration: 1.0
is: SBO:0000247
is: HMDB01338
is: CHEBI:57379
constant: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_410f9a18_4350_4e16_9829_6011a0cf5ecd
constant: false
boundary condition: true
name: GGT5
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: P36269
initial amount: NaN
is encoded by: hsa:2687

metaM methf c
constant: false
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: C00445
type: Species
is: CHEBI:57455
has only substance units: false
boundary condition: false
is: HMDB01354
initial concentration: 1.0
name: 5,10-Methenyltetrahydrofolate
is: SBO:0000247
initial amount: NaN

metaM taur x
has only substance units: false
type: Species
is: HMDB00251
constant: false
is: CHEBI:15891
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: taurine
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245

http://identifiers.org/biomodels.db/MODEL1310110055#_eb835271_ff4b_497c_a0d4_9ba4f9e11445
type: Species
is encoded by: hsa:AL038231
constant: false
name: _AL038231_1_c
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_937345f3_8ef8_45de_b253_f51f745879b8
type: Species
initial concentration: NaN
is encoded by: hsa:492
has only substance units: false
is: SBO:0000252
name: ATP2B3
boundary condition: true
constant: false
initial amount: NaN
is: Q16720

http://identifiers.org/biomodels.db/MODEL1310110055#_887cbbec_fc26_4c36_bc0f_4ef8726f435e
is: SBO:0000252
is encoded by: hsa:215
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: ABCD1
constant: false
type: Species
is: P33897
has only substance units: false

metaR r0160
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.1.3.2
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110055#
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
reactant: MODEL1310110055#
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_e46c358a_cd0c_406e_89a1_38415b5352d5
constant: false
type: Species
name: _BG035985_1_c
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:BG035985

metaM ksii core2 pre10 g
has only substance units: false
constant: false
name: keratan sulfate II biosynthesis, precursor 10
boundary condition: false
is: CHEBI:28067
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
initial concentration: 1.0

metaM mescoa m
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
is: CHEBI:27969
initial amount: NaN
type: Species
has only substance units: false
is: C06028
is: SBO:0000247
name: Mesaconyl-CoA
constant: false
initial concentration: 1.0
boundary condition: false

metaR HSD3B12r
is version of: http://identifiers.org/ec-code/1.1.1.145
notes: GENE_ASSOCIATION: (3284.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12832414 NOTES:kinetic studies done with recombinant human cDNA transfected into baculovirus
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
type: Reaction
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000176
is described by: ECO:0000134
product: MODEL1310110055#
fast: false
reversible: false
modifier: MODEL1310110055#

metaR DADA
is version of: http://identifiers.org/ec-code/3.5.4.4
kinetic law: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
is described by: ECO:0000269
name: Deoxyadenosine deaminase
reversible: false
reactant: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110055#_19197aa8_4809_4167_9c75_1303a242672b
initial concentration: NaN
is: P00492
is encoded by: hsa:3251
initial amount: NaN
has only substance units: false
constant: false
name: HPRT1
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_44f08560_3592_45bc_b861_7256ea84a9fd
boundary condition: true
initial concentration: NaN
is: O43868
type: Species
initial amount: NaN
name: SLC28A2
constant: false
is: SBO:0000252
is encoded by: hsa:9153
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_e4bff4ff_b913_40b1_bc55_e4e8dfeaa888
is: O75489
name: NDUFS3
is encoded by: hsa:4722
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false

metaM glu5p m
initial amount: NaN
name: L-Glutamate 5-phosphate
is: HMDB01228
is: CHEBI:58274
type: Species
has only substance units: false
notes: FORMULA: C5H8NO7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01092 EHMN_ABBREVIATION: C03287
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_495cd01d_ad82_45c1_b7e9_5dbc357a31b4
initial amount: NaN
initial concentration: NaN
is: Q16875
boundary condition: true
has only substance units: false
is encoded by: hsa:5209
name: PFKFB3
constant: false
type: Species
is: SBO:0000252

metaR DHFtm
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
kinetic law: MODEL1310110055#
reversible: true
reactant: MODEL1310110055#
product: MODEL1310110055#
name: dihydrofolate reversible mitochondrial transport
is: SBO:0000185
fast: false

metaM thcholstoic m
boundary condition: false
has only substance units: false
type: Species
is: HMDB03873
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial amount: NaN
is: SBO:0000247
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: CHEBI:18402
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_de2fc9c5_9d45_48cd_86a3_1180900d5d6a
boundary condition: true
is: O75912
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9162
has only substance units: false
type: Species
name: DGKI
is: SBO:0000252
constant: false

metaM psylchol e
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB11178
boundary condition: false
name: psillium-glycocholic acid complex
notes: FORMULA: C9642032H15428743NO8667420 CHARGE: 0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_a8c545b2_5796_4c78_bf5d_c264156a2006
name: _NM_001929_1_c
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:NM 001929
type: Species
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false

metaM gpi hs r
constant: false
has only substance units: false
is: SBO:0000247
type: Species
name: {[PE-Man-],[PE-]Man},{PE-}Man-GlcN-acylPI
initial amount: NaN
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
boundary condition: false
is: HMDB03125
is: CHEBI:16240

metaR TREHe
modifier: MODEL1310110055#
name: alpha,alpha-trehalase
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.28
product: MODEL1310110055#
fast: false
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
reactant: MODEL1310110055#

metaR EX psylchol LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium-glycocholic acid complex
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_0323ec99_cbbe_4535_898b_57c46651b104
constant: false
initial amount: NaN
initial concentration: NaN
name: CDIPT
is: O14735
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:10423

metaM CE1925 e
constant: false
notes: FORMULA: C16H21O4 CHARGE: -1 INCHI: InChI=1/C16H22O4/c1-9-10(2)15-12(11(3)14(9)19)5-7-16(4,20-15)8-6-13(17)18/h19H,5-8H2,1-4H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1925
name: 3'-carboxy-alpha-chromanol
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:57923
initial amount: NaN

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR LEUKTRF4t
is: SBO:0000185
reversible: true
name: leukotriene F4 transport
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110055#

metaR C4tcx
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine from peroxisomes
type: Reaction

metaR LNLNCGt
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110055#
is: SBO:0000185
name: fatty acid transport via diffusion
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_a3da37f7_70b4_49ec_b124_39c5ca898319
has only substance units: false
is: P61457
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:5092
name: PCBD1
type: Species
initial concentration: NaN
initial amount: NaN

metaM ala D c
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: HMDB01310
is: CHEBI:15570
name: D-alanine
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaM uri e
is: C00299
name: Uridine
has only substance units: false
is: HMDB00296
is: SBO:0000247
boundary condition: false
is: CHEBI:16704
type: Species
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
initial concentration: 1.0
initial amount: NaN
constant: false

metaR ASPte
reactant: MODEL1310110055#
is described by: ECO:0000134
kinetic law: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. no such transporter could be found so diffusion reaction is assumed. NOTES:
type: Reaction
fast: false
reversible: true
product: MODEL1310110055#
name: diffusion of aspartate into blood

metaM ksi deg18 l
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:12936
is: SBO:0000247
is: HMDB00143
name: keratan sulfate I, degradation product 18

http://identifiers.org/biomodels.db/MODEL1310110055#_161af001_f207_4723_a7b2_0e9e22d01b85
is encoded by: hsa:8309
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is: Q99424
boundary condition: true
name: ACOX2
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_5831f1ad_107c_4d32_a03c_85833dc231bb
is: P53004
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:644
name: BLVRA
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_f73a7a89_008c_4362_8c9d_0da02dcfa9f2
name: ST3GAL3
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6487
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_d6b9d422_c50d_48cb_b260_33fce0ac14f1
has only substance units: false
is encoded by: hsa:AI971036
boundary condition: true
name: _AI971036_1_c
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_6b371f99_38bd_41a7_8719_e440061af537
has only substance units: false
is encoded by: hsa:2348
is: SBO:0000252
constant: false
name: FOLR1
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_99bd8b3a_28bb_4dd9_b332_0b1c792969b9
boundary condition: true
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: GCK
is: SBO:0000252
is encoded by: hsa:2645
is: P35557
initial concentration: NaN

metaR LEUKTRE4t
fast: false
is: SBO:0000185
reactant: MODEL1310110055#
name: leukotriene E4 transport
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR ADPACDAc
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of adipic acid for formation of adipoyl carnitine
type: Reaction

metaM atp x
initial concentration: 1.0
has only substance units: false
is: CHEBI:57299
is: SBO:0000247
is: HMDB00538
boundary condition: false
name: ATP(4-)
initial amount: NaN
is: C00002
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_edbf863e_3100_40c9_9552_0a49830a8928
name: SLC34A2
boundary condition: true
is: O95436
is encoded by: hsa:10568
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species

metaM ksi pre35 g
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 35
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:28067
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_d42a09e6_96ac_4ad6_9a0e_fceadc7acba6
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: ATP5J2
has only substance units: false
is encoded by: hsa:9551
constant: false
is: F8W7V3
type: Species
initial amount: NaN

metaM HC00250 e
has only substance units: false
is: CHEBI:29919
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
name: hydrosulfide
boundary condition: false
initial amount: NaN
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283

metaM dodecanac x
notes: FORMULA: C12H20O4 CHARGE: -2
type: Species
name: Dodecanedioic acid
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00623
initial amount: NaN

metaR r1117
fast: false
is described by: ECO:0000000
product: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
reactant: MODEL1310110055#
is: SBO:0000185
reversible: true

metaR SPRMS
is version of: http://identifiers.org/ec-code/2.5.1.22
fast: false
modifier: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (6611.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.22 Confidence Level: 4 AUTHORS: PMID:7546290 NOTES:NCD
name: spermine synthase
product: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269

metaR 3HCO3 NAt
kinetic law: MODEL1310110055#
is described by: ECO:0000134
product: MODEL1310110055#
is: SBO:0000185
type: Reaction
fast: false
name: 3HCO3_NAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
reactant: MODEL1310110055#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_2b7b8bfb_92e4_4e04_a51c_930041c1067f
is encoded by: hsa:AW277253
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: _AW277253_1_c
initial concentration: NaN
type: Species
constant: false
has only substance units: false

metaM drib c
constant: false
name: 2-deoxy-D-ribose
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB03224
is: CHEBI:28816
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801

metaR IMPC
reactant: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000269
kinetic law: MODEL1310110055#
type: Reaction
product: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.3
name: IMP cyclohydrolase

metaR GARFT
type: Reaction
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.1.2.2
is described by: ECO:0000269
modifier: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
name: phosphoribosylglycinamide formyltransferase
fast: false

metaM hdcecrn m
is: SBO:0000247
is: HMDB00222
constant: false
name: Hexadecenoyl carnitine
boundary condition: false
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN

metaR FTHFCL
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (10588.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 4 AUTHORS: PMID:12764149 NOTES:NCD
type: Reaction
reversible: false
is: SBO:0000176
fast: false
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.3.3.2
name: 5-formethyltetrahydrofolate cyclo-ligase
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_4da5969c_b967_4c76_80c0_aab46786e62c
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: DGKD
is encoded by: hsa:8527
boundary condition: true
constant: false
initial concentration: NaN

metaR 4MPTNLte
name: 4-methylpentanal transport
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110055#
product: MODEL1310110055#
reversible: true
kinetic law: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110055#_2b5ef2a7_7cd9_47f4_a171_7679314c4e69
has only substance units: false
initial amount: NaN
name: _AI653169_1_c
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI653169
constant: false
boundary condition: true
type: Species

metaR IDOAASE2ly
is: SBO:0000176
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
product: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
reversible: false
name: alpha-L-iduronidase, lysosomal
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.76
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_6c8d6109_68d3_43d1_b7e2_2f23517f8d89
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaR OIVD1m
reactant: MODEL1310110055#
fast: false
reversible: false
modifier: MODEL1310110055#
is: SBO:0000176
product: MODEL1310110055#
name: 2-oxoisovalerate dehydrogenase (acylating; 4-methyl-2-oxopentaoate), mitochondrial
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.168
is version of: http://identifiers.org/ec-code/1.2.4.4
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
type: Reaction
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.8.1.4

metaR FAOXC180
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
modifier: MODEL1310110055#
product: MODEL1310110055#
name: Beta oxidation of long chain fatty acid
type: Reaction
reactant: MODEL1310110055#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_895bbcc2_1798_4d4d_92de_57937320e146
boundary condition: true
is encoded by: hsa:125
name: ADH1B
constant: false
type: Species
is: P00325
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_f81ef632_4bd2_47a5_a4ad_f8fd09e0b97c
is: Q674R7
is: SBO:0000252
has only substance units: false
name: ATG9B
boundary condition: true
initial amount: NaN
is encoded by: hsa:285973
constant: false
initial concentration: NaN
type: Species

MODEL1310110055
reaction: metaR r0668
reaction: metaR PPM
reaction: metaR r0308
species: metaM gullac r
species: metaM dgtp e
reaction: metaR C4DCCACT
reaction: metaR EX ppi LPAREN e RPAREN
species: metaM pmtcrn r
species: metaM hpdca e
species: metaM hmgcoa x
reaction: metaR ADMDC
reaction: metaR SGPL12r
reaction: metaR ENGASEly
species: metaM hcys L c
reaction: metaR FACOAL226
species: metaM strch2 e
reaction: metaR VLCS2p
reaction: metaR NACHEXA18ly
species: metaM aacoa m
reaction: metaR NAHCO3 HCLt
species: metaM cmp n
reaction: metaR sink octdececoa LPAREN c RPAREN
species: metaM xyl D c
is described by: http://identifiers.org/pubmed/23455439
species: metaM 34dhpac c
species: metaM 3ddcrn c
reaction: metaR C161CRN2t
reaction: metaR EX fe3 LPAREN e RPAREN
species: metaM ksi pre4 g
species: metaM ocdececrn c
reaction: metaR r0541
reaction: metaR RE3000M
reaction: metaR r1693
reaction: metaR r0170
reaction: metaR C30CPT1
reaction: metaR SQLSr
reaction: metaR r0179
reaction: metaR EX ser L LPAREN e RPAREN
reaction: metaR FAOXC4C4DCc
reaction: metaR AG13T4g
reaction: metaR INSTt4
species: metaM octe5coa x
species: metaM hdd2coa c
species: metaM 56dura c
reaction: metaR EX 3ivcrn
species: metaM hdcoa c
species: metaM 34dhmald c
species: metaM nwharg c
reaction: metaR r2393
reaction: metaR r0245
species: metaM xol7aone r
reaction: metaR THMP
reaction: metaR r2193
species: metaM retn e
reaction: metaR r0587
species: metaM HC01104 e
reaction: metaR PSt3
reaction: metaR DNDPt26m
species: metaM hs deg23 l
species: metaM HC02202 c
species: metaM dhcrm hs c
species: metaM pchol hs c
reaction: metaR EX tymsf LPAREN e RPAREN
species: metaM CE2434 m
reaction: metaR DOLPMT1 Ler
reaction: metaR NACHEXA11ly
species: metaM thymd c
reaction: metaR NDP7er
species: metaM l2fn2m2masn g
reaction: metaR FAOXC2031836m
reaction: metaR LDH D
reaction: metaR RETH
reaction: metaR r1920
reaction: metaR PROt4 2 r
reaction: metaR TYRPHELAT2tc
species: metaM fpram c
reaction: metaR CRNCAR3tp
reaction: metaR 5ADTSTSTERONEte
species: metaM etfrd m
reaction: metaR EX dtmp LPAREN e RPAREN

metaM gluside hs r
initial amount: NaN
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: CHEBI:18368
is: SBO:0000247
name: D-glucosyl-N-acylsphingosine

http://identifiers.org/biomodels.db/MODEL1310110055#_284e8484_29a8_4596_ad2b_c7fefb757a95
name: PKLR
constant: false
boundary condition: true
is encoded by: hsa:5313
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is: P30613

metaM dcholcoa c
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:28701
name: chenodeoxycholoyl coenzyme a
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial amount: NaN
is: HMDB06292
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_dad0dc7c_e5b0_4950_a45b_4d9006e39dcb
name: GLRX2
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:51022
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_946ba1ff_7400_4102_a078_adaf45121409
is: Q86YI5
is encoded by: hsa:1737
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: DLAT
has only substance units: false
constant: false
initial concentration: NaN

metaM formcoa x
name: formyl-CoA(4-)
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
constant: false
is: CHEBI:57376
initial amount: NaN
is: HMDB03419

metaM hs deg17 l
type: Species
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
is: CHEBI:21338
initial concentration: 1.0
has only substance units: false
is: HMDB02704
constant: false
initial amount: NaN
name: heparan sulfate, degradation product 17
boundary condition: false
is: SBO:0000247

metaR S6TASE8ly
fast: false
reversible: true
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is: SBO:0000176
type: Reaction
reactant: MODEL1310110055#

metaM 3decdicoa x
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
name: 3,7-decadienoylcoa

metaM 6thf e
constant: false
type: Species
name: hexaglutamyl folate (THF)
initial amount: NaN
is: http://identifiers.org/pubchem.compound/169691
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR r0629
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.6.1.22
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
product: MODEL1310110055#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.4.1
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110055#
is described by: ECO:0000000
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
fast: false

metaM 3dsphgn c
initial amount: NaN
is: CHEBI:58299
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
boundary condition: false
constant: false
is: SBO:0000247
type: Species
has only substance units: false
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
is: HMDB01480
initial concentration: 1.0

metaR DM dsT antigen g
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dsT antigen(g)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_aae46dfe_23a0_4d19_adb9_8d5744968140
is: P56381
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:514
name: ATP5E
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR PPAt
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
reactant: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110055#
name: Propionate transport, diffusion

metaR PHEMEtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV changed name to"tm" to indicate mitochondrial transport NCD
kinetic law: MODEL1310110055#
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#
name: Heme transport to cytosol

http://identifiers.org/biomodels.db/MODEL1310110055#_8177a0b9_e8f9_42a7_b4a5_4f7feaf40d6d
name: VNN1
initial amount: NaN
is: SBO:0000252
type: Species
is: O95497
is encoded by: hsa:8876
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false

metaR r1260
kinetic law: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
fast: false
name: EC:6.2.1.3
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000176
reversible: false
product: MODEL1310110055#

metaM mi134p c
boundary condition: false
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
is: CHEBI:58414
initial amount: NaN
is: HMDB01143
has only substance units: false
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0

metaM ksi pre22 g
name: keratan sulfate I biosynthesis, precursor 22
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
has only substance units: false
is: HMDB00175
type: Species
is: CHEBI:58053
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: C00130
initial amount: NaN

metaR SRTNtu
modifier: MODEL1310110055#
is described by: ECO:0000269
product: MODEL1310110055#
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
name: Serotonin uniport
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
type: Reaction
reversible: true
fast: false
is: SBO:0000185

metaR ACGAMPM
is described by: ECO:0000269
modifier: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.2.3
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
reversible: true
kinetic law: MODEL1310110055#
name: phosphoacetylglucosamine mutase
is: SBO:0000176
fast: false

metaM drib e
is: HMDB03224
type: Species
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
initial concentration: 1.0
is: CHEBI:28816
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
name: 2-deoxy-D-ribose
initial amount: NaN

metaR G14T21g
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reversible: false
reactant: MODEL1310110055#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110055#
is described by: ECO:0000000
fast: false

metaR r0166
reversible: false
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110055#
reactant: MODEL1310110055#
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_e163a048_74ec_4ac8_8d1e_3b4ee9ca9ecb
type: Species
boundary condition: true
is: Q9Y3Y1
name: SLC26A6
constant: false
is: SBO:0000252
is encoded by: hsa:65010
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM ksi deg29 l
type: Species
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I, degradation product 29
is: HMDB00143
is: CHEBI:12936
boundary condition: false

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

metaR r1116
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
product: MODEL1310110055#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110055#
type: Reaction
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_671931de_072c_4386_8fd7_7b04184784ba
has only substance units: false
name: PRDX2
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:7001
constant: false
boundary condition: true
type: Species
is: SBO:0000252

metaM glyc3p x
name: Glycerol 3-phosphate
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00126
is: CHEBI:57597
boundary condition: false
has only substance units: false
constant: false
is: C00093
is: SBO:0000247
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093

http://identifiers.org/biomodels.db/MODEL1310110055#_metaM_acglcgalacglcgal14acglcgalgluside_hs_g
has only substance units: false
is: SBO:0000247
name: (Gal)3 (Glc)1 (GlcNAc)3 (Cer)1
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0
type: Species
initial amount: NaN
constant: false
is: CHEBI:26174
initial concentration: 1.0
boundary condition: false

metaM air c
is: SBO:0000247
has only substance units: false
constant: false
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
type: Species
initial concentration: 1.0
boundary condition: false
is: C03373
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
is: CHEBI:58592
is: HMDB01235
initial amount: NaN

metaR DOPAtu
kinetic law: MODEL1310110055#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
product: MODEL1310110055#
fast: false
reversible: true
modifier: MODEL1310110055#
name: Dopamine uniport
reactant: MODEL1310110055#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_9f5beac6_8348_40be_862d_63cb8316047a
is: P53396
initial concentration: NaN
boundary condition: true
name: ACLY
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:47

metaR RE1526M
product: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: true
fast: false
name: RE1526
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_9cc78feb_3507_4a08_83db_5baa8a9b7e5b
is encoded by: hsa:349565
constant: false
name: NMNAT3
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q96T66
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_f75e5b5e_07f0_4741_aca8_3296299b8759
name: GMPR
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2766
is: P36959
type: Species

metaM ca2 e
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
constant: false
is: CHEBI:29108
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00464
name: calcium(2+)

http://identifiers.org/biomodels.db/MODEL1310110055#_dfa2ff10_39be_4ae5_9fb8_3d915a649032
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:84569
name: LYZL1
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: Q6UWQ5

metaM HC02207 c
is: CHEBI:27555
boundary condition: false
name: prostaglandin-c2
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
constant: false

metaM ethamp r
name: O-phosphonatoethanaminium(1-)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
initial amount: NaN
type: Species
is: CHEBI:58190
is: SBO:0000247
is: HMDB00224
has only substance units: false
constant: false

metaR SACCD3m
modifier: MODEL1310110055#
reactant: MODEL1310110055#
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.5.1.8
reversible: false
name: saccharopine dehydrogenase (NADP, L-lysine forming), mitochondrial
fast: false
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.8 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110055#

metaR TTDCAFATPc
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaR r0502
reactant: MODEL1310110055#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
reversible: true
modifier: MODEL1310110055#
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.1.113
is described by: ECO:0000000
is: SBO:0000176
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
kinetic law: MODEL1310110055#

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR ACGALtly
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
kinetic law: MODEL1310110055#
name: N-acetyl-galactosamine lysosomal efflux
is described by: ECO:0000000
product: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110055#_451a7a3e_fd87_4dcd_9829_ce8ca623d051
constant: false
is encoded by: hsa:2686
type: Species
initial concentration: NaN
has only substance units: false
name: GGT7
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: A0PJJ9

http://identifiers.org/biomodels.db/MODEL1310110055#_metaR_FUCFUCFUCGALACGLC13GALACGLCGAL14ACGLCGALGLUSIDEte
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
name: blood group intracellular transport
product: MODEL1310110055#
reversible: true

metaR GTHRDt
kinetic law: MODEL1310110055#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
type: Reaction
is: SBO:0000185
reactant: MODEL1310110055#
name: Glutathione transport into mitochondria
fast: false
product: MODEL1310110055#

metaR C101CPT1
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decenoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_6813854a_7ed6_4235_b69c_7d0379cf8f16
name: IDH2
is encoded by: hsa:3418
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P48735
boundary condition: true
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_6e93db05_2262_4617_b731_6e065df8a1b1
initial amount: NaN
name: ACAD9
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: Q9H845
is: SBO:0000252
is encoded by: hsa:28976
constant: false

metaR LNSTLSr
reactant: MODEL1310110055#
is described by: ECO:0000134
product: MODEL1310110055#
name: lanosterol synthase
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.4.99.7
reversible: false
type: Reaction
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

metaM clpn hs c
initial concentration: 1.0
is: CHEBI:21338
type: Species
has only substance units: false
constant: false
notes: FORMULA: CHARGE: 0
boundary condition: false
is: SBO:0000247
is: HMDB02704
initial amount: NaN
name: clpn_hs[c]

metaR r0739
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110055#
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1
type: Reaction
reactant: MODEL1310110055#
is: SBO:0000176
reversible: true
product: MODEL1310110055#
is described by: ECO:0000000
fast: false

metaR EX 3octdece1crn
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-octadecenoyl carnitine
type: Reaction

metaM nicrnt c
is: HMDB01132
name: Nicotinate D-ribonucleotide
is: C01185
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:57502
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_154315b2_ef10_4a0c_b5f5_331386a38b98
constant: false
type: Species
name: _AA977580_1_c
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:AA977580

metaM atp m
is: HMDB00538
is: CHEBI:57299
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: C00002
constant: false
initial amount: NaN
type: Species
name: ATP(4-)

metaR FAS120COA
is described by: ECO:0000269
product: MODEL1310110055#
name: fatty-acyl-CoA synthase (n-C12:0CoA)
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110055#
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR PETHCT
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (5833.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.14 Confidence Level: 4 AUTHORS: NOTES:NCD
name: phosphoethanolamine cytidyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.14
reactant: MODEL1310110055#
is: SBO:0000176
kinetic law: MODEL1310110055#
is described by: ECO:0000269
reversible: false
fast: false
product: MODEL1310110055#
type: Reaction

metaR RE1519M
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
name: RE1519
reactant: MODEL1310110055#
is: SBO:0000176
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
product: MODEL1310110055#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.13
type: Reaction
kinetic law: MODEL1310110055#
fast: false

metaM 4hphac e
name: 4-hydroxyphenylacetate
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB00020
is: CHEBI:48999
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM 2hexdtetcoa x
initial amount: NaN
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB02288
initial concentration: 1.0
name: 2,7,10,13-hexadecatetraenoylcoa
type: Species

metaM C02528 r
name: chenodeoxycholate
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:36234
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
has only substance units: false
is: HMDB00518
type: Species
boundary condition: false

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

metaR NADPtxu
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110055#
fast: false
name: NADP transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ potential for free H NJ
reversible: false
product: MODEL1310110055#
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_39b675cb_15a1_4fb5_9d2c_c6edfe2559e0
type: Species
initial concentration: NaN
name: ALG3
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:10195
constant: false
has only substance units: false

metaM stcrn m
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00848
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
name: stearoylcarnitine
is: SBO:0000247

metaM atp n
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00538
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
name: ATP(3-)
is: SBO:0000247
has only substance units: false
is: CHEBI:57299
constant: false
initial amount: NaN

metaM ca2 c
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
name: calcium(2+)
initial amount: NaN
is: CHEBI:29108
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: HMDB00464

metaM HC00250 c
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:29919
name: hydrosulfide
type: Species
initial amount: NaN
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial concentration: 1.0
has only substance units: false

metaR ACt2m
kinetic law: MODEL1310110055#
product: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
type: Reaction
reactant: MODEL1310110055#
is: SBO:0000185
reversible: true
name: acetate mitochondrial transport via proton symport
is described by: ECO:0000000

metaM pmtcoa r
boundary condition: false
constant: false
is: SBO:0000247
is: C00154
initial concentration: 1.0
name: Palmitoyl-CoA (n-C16:0CoA)
type: Species
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
has only substance units: false
is: HMDB01338
is: CHEBI:3454
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_metaR_FUCFUCFUCGALACGLC13GALACGLCGAL14ACGLCGALGLUSIDEtg
kinetic law: MODEL1310110055#
name: blood group intracellular transport
fast: false
reversible: true
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
product: MODEL1310110055#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_9025740e_4738_4699_b8aa_35fcb012d9d0
has part: O95497
is: SBO:0000297
is encoded by: hsa:8876
boundary condition: true
initial amount: NaN
type: Species
has part: A8K7W0
is encoded by: hsa:8875
is encoded by: hsa:55350
constant: false
initial concentration: NaN
name: VNN3:VNN2:VNN1
has only substance units: false

metaM g3m8mpdol L r
is: C00459
is: HMDB01342
initial amount: NaN
notes: FORMULA: C1960H3228N20O770P20 CHARGE: -20
constant: false
has only substance units: false
is: CHEBI:37568
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_2c716a03_953f_4632_b308_d6087773518c
name: MAOB
is encoded by: hsa:4129
initial amount: NaN
is: SBO:0000252
type: Species
is: P27338
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_a7a3023c_460e_4bf9_9409_d63190064789
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:117248
constant: false
has only substance units: false
name: GALNTL2
is: Q8N3T1
initial amount: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_da13f0fb_c846_4b35_ae92_34c4abdc825a
is encoded by: hsa:276
initial amount: NaN
is: SBO:0000252
name: AMY1A
boundary condition: true
is: Q6NSB3
type: Species
initial concentration: NaN
constant: false
has only substance units: false

metaR MTHFCm
type: Reaction
modifier: MODEL1310110055#
reversible: true
is described by: ECO:0000269
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/6.3.4.3
is version of: http://identifiers.org/ec-code/3.5.4.9
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
fast: false
is: SBO:0000176
reactant: MODEL1310110055#

metaR ALACYSNaEx
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
reversible: false
fast: false
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110055#

metaM gbside hs l
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
name: globoside
is: CHEBI:18259
boundary condition: false
constant: false
has only substance units: false

metaR DMNONCRNCPT2
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
fast: false
is: SBO:0000176
product: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
reversible: true
kinetic law: MODEL1310110055#
name: DMNONCRNCPT2
type: Reaction

metaM eicostet c
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: eicosatetranoic acid
is: HMDB02177
constant: false
is: CHEBI:36033
notes: FORMULA: C20H31O2 CHARGE: -1

metaM ala D e
boundary condition: false
type: Species
name: D-alanine
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: HMDB01310
is: CHEBI:15570
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN

metaM 4hphac c
is: SBO:0000247
name: 4-hydroxyphenylacetate
boundary condition: false
has only substance units: false
type: Species
constant: false
is: CHEBI:48999
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
is: HMDB00020

metaM ddeccrn e
is: HMDB02250
boundary condition: false
initial amount: NaN
notes: FORMULA: C19H37NO4 CHARGE: 0
name: lauroyl carnitine
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
has only substance units: false

metaR r2401
kinetic law: MODEL1310110055#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is described by: ECO:0000000
product: MODEL1310110055#
is: SBO:0000185
reactant: MODEL1310110055#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaM hs deg1 l
is: HMDB01352
is: CHEBI:17180
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
name: heparan sulfate, degradation product 1
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_fb52b960_779b_4522_a5b7_08e8147658c0
is encoded by: hsa:4707
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: NDUFB1
is: O75438
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaR TYRTA
fast: false
is described by: ECO:0000269
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110055#
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.6.1.1
type: Reaction
name: tyrosine transaminase
reactant: MODEL1310110055#

metaR NICRNS
is described by: ECO:0000000
reactant: MODEL1310110055#
is: SBO:0000176
fast: false
product: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#
name: NICRNS
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_faa0a07a_34fe_4bd9_9e4a_ee14641e624b
is encoded by: hsa:5230
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is: P00558
constant: false
name: PGK1

metaR r1020
is described by: ECO:0000000
kinetic law: MODEL1310110055#
type: Reaction
reversible: true
name: Postulated transport reaction
fast: false
is: SBO:0000185
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_f050195a_02b8_4d15_8e7c_c664bff8e56d
is: SBO:0000252
name: FOLR1
is encoded by: hsa:2348
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false
has only substance units: false

metaM xol27oh r
boundary condition: false
is: CHEBI:17703
name: 26-hydroxycholesterol
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: HMDB02103
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_a8164927_8fa2_4c57_b04f_f923e32fe4bf
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
name: SLC35C1
is: SBO:0000252
is encoded by: hsa:55343
is: B3KQH0

metaR PPAn
fast: false
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000000
is: SBO:0000176
name: inorganic diphosphatase, nuclear
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110055#
reversible: false

metaR FAOXC16180m
reactant: MODEL1310110055#
is described by: ECO:0000269
name: Beta oxidation fatty acid
type: Reaction
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110055#

metaR G6PDA
reversible: false
kinetic law: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#
is: SBO:0000176
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.5.99.6
notes: GENE_ASSOCIATION: (132789.1) or (10007.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.99.6 Confidence Level: 4 AUTHORS: PMID:9714720 NOTES:Previously EC 5.3.1.10
name: glucosamine-6-phosphate deaminase
fast: false
is described by: ECO:0000269
modifier: MODEL1310110055#

metaR CYTK11n
modifier: MODEL1310110055#
is: SBO:0000176
reversible: true
type: Reaction
name: cytidylate kinase (dCMP,dGTP),nuclear
product: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110055#

metaR RE0583C
kinetic law: MODEL1310110055#
type: Reaction
is: SBO:0000176
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000000
reversible: true
name: RE0583
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
fast: false

metaR r1538
is described by: ECO:0000000
product: MODEL1310110055#
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.17.4.1
kinetic law: MODEL1310110055#
reversible: false
type: Reaction
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_1c93a43a_a084_46c1_9b5a_3552367ffb89
has only substance units: false
initial amount: NaN
type: Species
name: ATP5G2
constant: false
is encoded by: hsa:517
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_a50dc10b_fd5f_4a28_af87_6a6573ff5bc6
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P17568
initial amount: NaN
constant: false
name: NDUFB7
boundary condition: true
type: Species
is encoded by: hsa:4713

http://identifiers.org/biomodels.db/MODEL1310110055#_b3a16e0d_db69_4a15_b853_6a81a2580b5c
is: P00441
is: SBO:0000252
name: SOD1
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:6647
type: Species
initial concentration: NaN

metaR RE3626M
name: RE3626
reversible: false
kinetic law: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reactant: MODEL1310110055#
product: MODEL1310110055#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_15987ebd_2af2_4a09_8292_0eccbc5e3ae6
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6510
is: Q15758
initial amount: NaN
type: Species
is: SBO:0000252
name: SLC1A5

metaM ddeccrn c
has only substance units: false
name: lauroyl carnitine
type: Species
notes: FORMULA: C19H37NO4 CHARGE: 0
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB02250

metaM eicostet e
is: SBO:0000247
notes: FORMULA: C20H31O2 CHARGE: -1
type: Species
initial amount: NaN
boundary condition: false
is: HMDB02177
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:36033
name: eicosatetranoic acid

metaR EX c8crn
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_a0cb8687_220c_4992_931e_b638d6adfeb6
is: O14734
has only substance units: false
type: Species
is: SBO:0000252
name: ACOT8
is encoded by: hsa:10005
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_82ca978c_8702_4d07_b7ad_cf775e628b34
constant: false
is: Q9UBQ7
name: GRHPR
is encoded by: hsa:9380
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_8e989e35_24ba_44c3_818d_c1c785968128
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:64849
constant: false
boundary condition: true
initial concentration: NaN
is: Q8WWT9
name: SLC13A3
type: Species
has only substance units: false

metaM HC02207 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: CHEBI:27555
has only substance units: false
name: prostaglandin-c2
initial concentration: 1.0
boundary condition: false

metaR r0504
fast: false
type: Reaction
reversible: true
product: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.3.3.10
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#

metaM malttr e
is: C01835
type: Species
is: CHEBI:27931
initial concentration: 1.0
is: HMDB01262
has only substance units: false
is: SBO:0000247
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
initial amount: NaN
name: maltotriose
boundary condition: false
constant: false

metaM hs deg15 l
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
name: heparan sulfate, degradation product 15
initial concentration: 1.0
is: CHEBI:16126
is: SBO:0000247
notes: FORMULA: C49H71N2O57S5 CHARGE: -7

metaM methf m
is: HMDB01354
name: (6R)-5,10-methenyltetrahydrofolate
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57455
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
constant: false
type: Species

metaM atp r
boundary condition: false
type: Species
is: CHEBI:57299
initial concentration: 1.0
is: C00002
initial amount: NaN
has only substance units: false
name: ATP(4-)
is: SBO:0000247
is: HMDB00538
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_811a4e0e_155f_45ba_af59_3f51fcbeed1c
boundary condition: true
constant: false
is: P56556
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4700
name: NDUFA6
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_fdc4cdfb_60f6_4577_abac_5d92ea5545ab
type: Species
is: SBO:0000252
is encoded by: hsa:X63359
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: _X63359_1_c
constant: false

metaM galgluside hs g
is: SBO:0000247
initial amount: NaN
name: galactosyl glucosyl ceramide
type: Species
is: HMDB00295
is: CHEBI:58223
is: C00015
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
constant: false
boundary condition: false

metaR CSNATr
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
name: carnitine O-acetyltransferase
product: MODEL1310110055#
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_0cb91f01_a0cd_445c_802f_f8abdf7a80fd
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4905
is: P46459
type: Species
has only substance units: false
name: NSF
initial amount: NaN

metaM thcholstoic c
is: SBO:0000247
is: CHEBI:18402
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
has only substance units: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB03873

metaM pmtcoa m
constant: false
is: SBO:0000247
name: Palmitoyl-CoA (n-C16:0CoA)
has only substance units: false
is: CHEBI:57379
is: C00154
type: Species
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB01338

metaR DLNLCGCRNt
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
kinetic law: MODEL1310110055#
type: Reaction
reversible: false
is described by: ECO:0000000
name: transport into the mitochondria (carnitine)
reactant: MODEL1310110055#
product: MODEL1310110055#
modifier: MODEL1310110055#

metaR LACLt
name: Lactate transport
product: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMCID: PMC1820816. NOTES:for regeneration of nad in peroxisomes, for providing nad to the beta oxidation
reactant: MODEL1310110055#
fast: false
is: SBO:0000185
is described by: ECO:0000134
reversible: false
type: Reaction

metaM 5adtststerones e
is: HMDB06278
has only substance units: false
boundary condition: false
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
initial concentration: 1.0
constant: false
is: SBO:0000247
name: 5alpha-Dihydrotestosterone sulfate
type: Species
initial amount: NaN

metaR DNDPt14m
type: Reaction
modifier: MODEL1310110055#
fast: false
product: MODEL1310110055#
name: dUDP transport via dTDP antiport
reactant: MODEL1310110055#
is: SBO:0000185
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110055#

metaR GCCcm
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.1.2.10
is described by: ECO:0000269
reactant: MODEL1310110055#
reversible: true
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
name: glycine-cleavage complex (lipoylprotein), mitochondrial
is version of: http://identifiers.org/ec-code/1.4.4.2
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110055#_8942598f_0cc1_4650_9f09_df69b1a25912
is: P30049
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:513
has only substance units: false
name: ATP5D

metaR URIt5le
fast: false
kinetic law: MODEL1310110055#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110055#
reversible: false
name: uridine transport in via sodium symport (1:2)
is described by: ECO:0000134
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
modifier: MODEL1310110055#

metaR r0731
fast: false
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110055#
reversible: false
is described by: ECO:0000000
product: MODEL1310110055#

metaM sebcoa c
boundary condition: false
name: sebacoylcoa
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00651
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
type: Species
has only substance units: false
initial concentration: 1.0

metaM prostgd2 r
has only substance units: false
constant: false
type: Species
name: prostaglandin D2(1-)
is: CHEBI:57406
initial amount: NaN
is: HMDB01403
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696

metaR UAG2EMAi
reversible: false
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/5.1.3.14
is: SBO:0000176
type: Reaction
name: UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
fast: false

metaR r1691
product: MODEL1310110055#
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
fast: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_636d4c13_ef6b_41d8_af7c_92f6b23eb135
is encoded by: hsa:4713
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: NDUFB7
boundary condition: true
is: P17568
initial amount: NaN

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_251c60f6_210c_46c3_8553_af288a5d6000
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:57835
boundary condition: true
name: SLC4A5
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_981f5cd0_0a52_41da_95a7_ddc6094976d6
initial concentration: NaN
name: ACADM
type: Species
is: P11310
is: SBO:0000252
constant: false
is encoded by: hsa:34
has only substance units: false
boundary condition: true
initial amount: NaN

metaR r0732
reversible: false
type: Reaction
product: MODEL1310110055#
is: SBO:0000176
fast: false
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110055#

metaM m6masnC g
is: HMDB06529
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:50570
initial concentration: 1.0
notes: FORMULA: C58H97N2O45X CHARGE: 0
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false
constant: false
type: Species

metaM itp n
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
constant: false
is: HMDB00189
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: CHEBI:57614
is: SBO:0000247
initial concentration: 1.0
name: ITP(3-)

metaM leuktrF4 e
type: Species
constant: false
is: CHEBI:27491
initial amount: NaN
is: HMDB06465
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: leukotriene F4
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
is: SBO:0000247

metaM dolp L c
constant: false
name: dolichyl phosphate(2-)
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:57683
initial amount: NaN
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: SBO:0000247
type: Species

metaR r1751
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
product: MODEL1310110055#
is: SBO:0000185
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
type: Reaction

metaM acrn r
boundary condition: false
is: CHEBI:57589
has only substance units: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: HMDB00201
type: Species
is: SBO:0000247
name: O-acetylcarnitine
constant: false
initial concentration: 1.0
initial amount: NaN

metaR CYSALANaEx
modifier: MODEL1310110055#
reversible: false
name: L-alanine/L-cysteine Na-dependent exchange (Cys-L in)
product: MODEL1310110055#
is described by: ECO:0000269
reactant: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185

metaM atp c
is: HMDB00538
initial amount: NaN
constant: false
is: C00002
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:30616
initial concentration: 1.0
name: ATP(4-)

metaR r1690
fast: false
is: SBO:0000185
product: MODEL1310110055#
kinetic law: MODEL1310110055#
name: Y+LAT2 Utilized transport
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110055#
reversible: false

metaM crvnc c
has only substance units: false
name: cervonic acid, C22:6 n-3
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB02183
boundary condition: false
type: Species
is: CHEBI:36005
notes: FORMULA: C22H31O2 CHARGE: -1

metaR ACNAM9PL
product: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/2.5.1.56
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
fast: false

metaR ABO4g
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
is version of: http://identifiers.org/ec-code/2.4.1.37
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110055#
fast: false
is: SBO:0000176
reversible: false

metaR LYStm
is: SBO:0000185
name: Lysine mitochondrial transport via ornithine carrier
reversible: true
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reactant: MODEL1310110055#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110055#
product: MODEL1310110055#
type: Reaction

metaR LNLNCACPT1
reversible: false
is described by: ECO:0000269
type: Reaction
name: carnitine O-palmitoyltransferase
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110055#

metaR TAURtcx
reversible: true
name: taurine transport (sodium symport) (cytosol to peroxisome)
is described by: ECO:0000212
is: SBO:0000185
type: Reaction
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:8010975 NOTES:SAB
product: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
modifier: MODEL1310110055#

metaR FE2tm
product: MODEL1310110055#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10383398,PMID:12755454 NOTES:TDV Lange H, 1999.
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
name: iron (II) transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_90ee3704_4581_4e64_aa09_392dd2a8b693
constant: false
initial concentration: NaN
name: CHAT
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:1103
is: D3DX95
has only substance units: false

metaR CSBPASEly
type: Reaction
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
reactant: MODEL1310110055#
fast: false
reversible: false
kinetic law: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
is described by: ECO:0000000
product: MODEL1310110055#

metaR DLNLCGt
type: Reaction
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000185
name: fatty acid transport via diffusion
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reactant: MODEL1310110055#
is described by: ECO:0000000

metaR r1750
reversible: false
product: MODEL1310110055#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110055#
fast: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110055#
is described by: ECO:0000000
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR S6T2g
is: SBO:0000176
product: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: false
reactant: MODEL1310110055#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110055#

metaR G14T10g
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
reversible: false
reactant: MODEL1310110055#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

metaM core6 g
initial amount: NaN
boundary condition: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
name: Core 6
is: CHEBI:16478
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0

metaM ksii core2 pre8 g
has only substance units: false
boundary condition: false
is: HMDB00175
constant: false
is: SBO:0000247
is: C00130
type: Species
initial concentration: 1.0
notes: FORMULA: C75H121N6O56SX CHARGE: -2
is: CHEBI:58053
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 8

metaM ksi deg20 l
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
is: CHEBI:12936
is: HMDB00143
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
name: keratan sulfate I, degradation product 20
initial amount: NaN

metaM ps hs m
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
is: CHEBI:18303
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
has only substance units: false
name: ps_hs[m]
initial amount: NaN
boundary condition: false

metaM dadp c
is: C00206
name: dADP
has only substance units: false
boundary condition: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
type: Species
is: HMDB01508
is: CHEBI:57667
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN

metaM formcoa c
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
constant: false
is: CHEBI:57376
initial amount: NaN
is: HMDB03419
name: formyl-CoA(4-)
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species

metaR FACOAL2251
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
fast: false
modifier: MODEL1310110055#
product: MODEL1310110055#
name: fatty-acid--CoA ligase
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110055#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_de5b4cba_f515_48ff_991b_88eed84ab665
initial concentration: NaN
constant: false
name: SLC6A2
is: Q96KH8
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6530
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_277085b4_a76a_4ee1_ab67_91fdb11ce9d0
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: MSMO1
constant: false
is encoded by: hsa:6307
is: A8MYF6

metaR r0730
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110055#
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
reactant: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000000
kinetic law: MODEL1310110055#
reversible: false

metaM c226coa m
is: http://identifiers.org/pubchem.compound/47205479
is: C16169
is: SBO:0000247
name: cervonyl coenzyme A
constant: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0

metaM crvnc e
notes: FORMULA: C22H31O2 CHARGE: -1
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB02183
name: cervonic acid, C22:6 n-3
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:36005

metaR LNLNCACPT2
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is: SBO:0000176

metaM hdcecrn c
type: Species
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
initial concentration: 1.0
constant: false
name: Hexadecenoyl carnitine
is: SBO:0000247
has only substance units: false
is: HMDB00222
initial amount: NaN
boundary condition: false

metaM leuktrF4 c
has only substance units: false
is: HMDB06465
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
name: leukotriene F4
initial amount: NaN
boundary condition: false
is: CHEBI:27491

metaM atp e
is: C00002
has only substance units: false
name: ATP(4-)
boundary condition: false
constant: false
is: CHEBI:57299
is: HMDB00538
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_718b901d_04d0_497d_baaf_a0dfc257c0c0
type: Species
is: SBO:0000252
is encoded by: hsa:23475
constant: false
name: QPRT
boundary condition: true
is: Q15274
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM HC02216 c
initial amount: NaN
is: CHEBI:28922
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
constant: false
initial concentration: 1.0
name: prostaglandin-f2beta
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_53c9a7b1_4cb8_4fda_a925_d03c795b8fee
name: IDH1
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:3417
is: O75874
constant: false
has only substance units: false
is: SBO:0000252

metaR r0735
product: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
fast: false
modifier: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is described by: ECO:0000000
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reversible: true

metaR H2Oter
kinetic law: MODEL1310110055#
reversible: true
name: H2O endoplasmic reticulum transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaM n2m2nmn l
has only substance units: false
constant: false
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16680
is: HMDB00939
notes: FORMULA: C50H84N4O36 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110055#_43d6edd5_31f0_4784_bd0e_f5487d49140d
has only substance units: false
name: SLC24A1
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: B4DUG1
is encoded by: hsa:9187
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_6892ccb3_06c4_4ed3_b5d9_d285c7a0bc73
constant: false
initial amount: NaN
is encoded by: hsa:126129
is: SBO:0000252
boundary condition: true
is: Q8TCG5
name: CPT1C
type: Species
has only substance units: false
initial concentration: NaN

metaR KSIt
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: keratan sulfate I transport, golgi to extracellular
kinetic law: MODEL1310110055#
type: Reaction
fast: false
reactant: MODEL1310110055#
reversible: false

metaR KAS8
is described by: ECO:0000269
kinetic law: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
reactant: MODEL1310110055#
type: Reaction
reversible: false
is: SBO:0000176
modifier: MODEL1310110055#
name: b-ketoacyl synthetase (palmitate, n-C16:0)

metaR THRGLNNaEx
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110055#
fast: false
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#
name: L-threonine/L-glutamine Na-dependent exchange (Thr-L in)
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_3fc19dd3_70ac_4000_a267_4cae6c45a868
is encoded by: hsa:11041
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
name: B3GNT1
type: Species
is: O43505
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_70f0117e_d0fc_4801_879b_b0b1bcd99d5e
initial concentration: NaN
is encoded by: hsa:4047
is: SBO:0000252
is: E9PEI9
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species
name: LSS

http://identifiers.org/biomodels.db/MODEL1310110055#_metaM_galacgalfuc12gal14acglcgalgluside_hs_g
is: CHEBI:26174
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C64H112N3O36FULLRCO CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: (Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
type: Species

metaM strdnc c
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: C16300
boundary condition: false
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/47205608
is: HMDB06547
name: stearidonic acid C18:4, n-3
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species

metaM gal e
is: C00124
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:0
constant: false
type: Species
boundary condition: false
has only substance units: false
is: HMDB00143
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0
name: D-Galactose

metaR PRGSTRNt
kinetic law: MODEL1310110055#
fast: false
product: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110055#
name: Progesterone transport

http://identifiers.org/biomodels.db/MODEL1310110055#_571c23fe_6f19_4634_89ad_c3d228c1605b
is encoded by: hsa:1103
boundary condition: true
constant: false
name: CHAT
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q6LEN6

metaM core6 l
initial concentration: 1.0
type: Species
is: CHEBI:12936
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: HMDB00143
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
name: Core 6

metaM HC01410 m
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
is: SBO:0000247
type: Species
name: (2E)-Hexenoyl-CoA
has only substance units: false
is: CHEBI:28706
initial concentration: 1.0

metaM dcsptn1 e
name: docosa-4,7,10,13,16-pentaenoic acid
is: SBO:0000247
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
constant: false
type: Species
is: HMDB13123
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/5282848

metaR r0733
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.12
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
modifier: MODEL1310110055#
reversible: false
fast: false
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110055#

metaM HC02216 e
constant: false
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin-f2beta
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:28922

http://identifiers.org/biomodels.db/MODEL1310110055#_39ba73ed_7124_478b_812e_5428ea5dfa6c
name: AK4
is encoded by: hsa:205
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species

metaR PDE1
is version of: http://identifiers.org/ec-code/3.1.4.17
reactant: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
fast: false
modifier: MODEL1310110055#
name: 3',5'-cyclic-nucleotide phosphodiesterase
type: Reaction
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.35

metaM 5adtststerones c
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB06278
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
name: 5alpha-Dihydrotestosterone sulfate
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false

metaM acrn m
name: O-acetylcarnitine
is: CHEBI:57589
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00201
boundary condition: false

metaM nrpphrsf c
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/123747
is: HMDB02062
has only substance units: false
name: Sulfate derivative of norepinephrine
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
type: Species

metaR r1540
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110055#
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
reversible: false
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3

metaM bilirub r
name: bilirubin(2-)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:57977
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
has only substance units: false
constant: false
is: HMDB00054
initial amount: NaN

metaR r0734
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
product: MODEL1310110055#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_c676501e_4c16_455d_89dc_ba9d28e9972c
initial amount: NaN
is: P54819
initial concentration: NaN
is: SBO:0000252
name: AK2
is encoded by: hsa:204
has only substance units: false
constant: false
boundary condition: true
type: Species

metaM gal c
initial concentration: 1.0
is: C00124
is: CHEBI:0
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0
is: HMDB00143
name: D-Galactose
initial amount: NaN

metaM strdnc e
is: C16300
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
constant: false
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205608
is: HMDB06547
initial amount: NaN
is: SBO:0000247
type: Species
name: stearidonic acid C18:4, n-3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_031a2d7c_417b_42e6_a98a_90f096dfa299
boundary condition: true
is: P28332
type: Species
initial amount: NaN
name: ADH6
is encoded by: hsa:130
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaM dcsptn1 c
name: docosa-4,7,10,13,16-pentaenoic acid
is: http://identifiers.org/pubchem.compound/5282848
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB13123
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_24af5d21_54a3_4438_9b0a_2043681951e2
initial amount: NaN
is: O00767
has only substance units: false
boundary condition: true
is encoded by: hsa:6319
constant: false
is: SBO:0000252
type: Species
name: SCD
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_9fcbc4d3_a404_4256_90c0_1afa6cfb75c2
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: O95427
is: SBO:0000252
is encoded by: hsa:23556
initial amount: NaN
constant: false
name: PIGN

metaR DPGM
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.13
reactant: MODEL1310110055#
reversible: true
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (669.1) or (5223.1) or (5224.2) or (5224.1) or (669.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.1 Confidence Level: 0 AUTHORS: PMID:15949708,PMID:17052986 NOTES:
product: MODEL1310110055#
name: Diphosphoglyceromutase
is: SBO:0000176
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110055#

metaM nrpphrsf e
type: Species
is: SBO:0000247
is: HMDB02062
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
constant: false
is: http://identifiers.org/pubchem.compound/123747
name: Sulfate derivative of norepinephrine

metaM g1m8masn r
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false
is: C05875
notes: FORMULA: C76H127N2O60X CHARGE: 0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_1a541559_1147_4e53_aa73_522ed9408f4f
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
name: SLC2A7
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:155184
is: Q6PXP3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_f1e4a2b3_c806_43ec_96e0_a1ca3cb981dd
is: P36551
is encoded by: hsa:1371
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: CPOX
constant: false
type: Species
is: SBO:0000252
has only substance units: false

metaM zymstnl r
name: 5alpha-cholest-8-en-3beta-ol
is: HMDB06841
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:16608
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_8e8b0b2b_badb_447f_b1cf_98b36f151e9c
name: ATP5H
type: Species
is encoded by: hsa:10476
initial concentration: NaN
has only substance units: false
is: O75947
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_22263b3f_bfb8_4113_9060_50e156b27c7c
has only substance units: false
is encoded by: hsa:3283
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: HSD3B1
type: Species
is: SBO:0000252
is: P14060
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_ff02c522_1d2c_4f1a_9c0e_5524fd686d39
initial concentration: NaN
type: Species
initial amount: NaN
is: Q8NFL0
has only substance units: false
is: SBO:0000252
name: B3GNT7
boundary condition: true
constant: false
is encoded by: hsa:93010

metaM dlnlcg e
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
has only substance units: false
is: HMDB02925
initial amount: NaN
name: dihomo-gamma-linolenic acid (n-6)
type: Species
boundary condition: false
is: CHEBI:53486

metaR 5ADTSTSTERONEte
reactant: MODEL1310110055#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
type: Reaction
name: 5 alpha dihydrotesterone transport
is described by: ECO:0000000
product: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false

metaR RE3520E
product: MODEL1310110055#
is: SBO:0000176
kinetic law: MODEL1310110055#
is described by: ECO:0000000
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
is version of: http://identifiers.org/ec-code/1.11.1.9
reversible: true
type: Reaction
fast: false
name: RE3520
reactant: MODEL1310110055#

metaR SUCRe
name: sucrose hydrolyzing enxyme, extracellular
notes: GENE_ASSOCIATION: (6476.1) or (8972.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.26 Confidence Level: 4 AUTHORS: PMID:1560017,PMID:3143729 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.20
modifier: MODEL1310110055#
is described by: ECO:0000269
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.10
reversible: false
fast: false
reactant: MODEL1310110055#
type: Reaction

metaR HPDCAt
kinetic law: MODEL1310110055#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
type: Reaction
reactant: MODEL1310110055#
reversible: true
product: MODEL1310110055#
is described by: ECO:0000000
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110055#_c20eaddd_f476_4f73_8c3e_538fee86a805
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: ABCB4
type: Species
is encoded by: hsa:5244
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_c38b76e9_db3b_44ae_b2da_53d6e41fc1b8
initial concentration: NaN
is: SBO:0000252
constant: false
name: PRDX3
boundary condition: true
initial amount: NaN
is: P30048
type: Species
has only substance units: false
is encoded by: hsa:10935

http://identifiers.org/biomodels.db/MODEL1310110055#_99d48dc9_a225_4f81_87b4_ad8126fe3384
name: HADHB
initial concentration: NaN
is encoded by: hsa:3032
constant: false
has only substance units: false
type: Species
is: P55084
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM m6mpdol L r
notes: FORMULA: C1660H2728N20O520P20 CHARGE: -20
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:37635
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_abd805d1_aecb_4aaf_94bd_4efb399e6497
type: Species
name: H6PD
initial concentration: NaN
constant: false
is encoded by: hsa:9563
boundary condition: true
is: O95479
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_def9348b_1cb9_49d8_936c_1b7917c159fc
initial amount: NaN
has only substance units: false
constant: false
name: HAO2
initial concentration: NaN
is encoded by: hsa:51179
is: SBO:0000252
type: Species
boundary condition: true
is: Q9NYQ3

metaR r0627
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
is described by: ECO:0000000
product: MODEL1310110055#
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
fast: false

metaR r1109
product: MODEL1310110055#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_7bc5433e_39b6_433d_bad4_d028bdcb9124
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:10632
constant: false
initial amount: NaN
name: ATP5L
is: O75964

metaR LALDO
type: Reaction
reversible: true
reactant: MODEL1310110055#
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
is: SBO:0000176
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.1
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_9d782ea5_4411_4dc7_aa3e_956e35806a5e
constant: false
is encoded by: hsa:2588
initial concentration: NaN
name: GALNS
type: Species
initial amount: NaN
has only substance units: false
is: P34059
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_14114436_ecee_4497_abfb_4b7d573381df
is encoded by: hsa:2592
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
name: GALT
is: B4E097
constant: false
initial amount: NaN
is: SBO:0000252

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_1defa3f9_e252_4be1_8d8c_f7d33d2e8cf1
is encoded by: hsa:10558
initial concentration: NaN
has only substance units: false
name: SPTLC1
is: SBO:0000252
is: O15269
initial amount: NaN
type: Species
boundary condition: true
constant: false

metaM ps hs e
initial amount: NaN
name: phosphatidylserine
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
is: CHEBI:18303
constant: false
initial concentration: 1.0
type: Species
has only substance units: false

metaR TSTSTERONEtr
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fast: false
is: SBO:0000185
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110055#
name: testosterone intracellular transport

metaM itp e
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00189
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: CHEBI:57614
name: ITP(3-)

http://identifiers.org/biomodels.db/MODEL1310110055#_a5cf8452_1f18_44f5_9a92_e1630ad4fe68
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:212
initial amount: NaN
name: ALAS2
is: Q5JZF5
boundary condition: true
constant: false
has only substance units: false

metaR P5CDm
fast: false
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.5.1.12
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
kinetic law: MODEL1310110055#
reversible: false
product: MODEL1310110055#

metaR FAOXC80
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
is described by: ECO:0000269
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110055#
type: Reaction
name: Beta oxidation of med/long chain fatty acid
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_ef012ff7_ead1_4cd3_a86a_e6303c5f6bd0
has only substance units: false
boundary condition: true
name: PMVK
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q6FGV9
is encoded by: hsa:10654
type: Species
initial amount: NaN

metaR CORE4GTg
kinetic law: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.102
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
type: Reaction
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
product: MODEL1310110055#
modifier: MODEL1310110055#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110055#
fast: false

metaM ksi deg11 l
is: HMDB00143
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:12936
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
name: keratan sulfate I, degradation product 11

metaM acrn x
name: O-acetylcarnitine
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
type: Species
is: HMDB00201
boundary condition: false
is: CHEBI:57589
initial amount: NaN
constant: false

metaM andrstrn r
initial concentration: 1.0
is: HMDB00031
constant: false
has only substance units: false
type: Species
is: CHEBI:16032
initial amount: NaN
name: androsterone
is: SBO:0000247
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
boundary condition: false

metaM 44mzym r
constant: false
is: CHEBI:18364
has only substance units: false
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
is: HMDB01286
name: 14-demethyllanosterol
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaM f26bp c
is: HMDB01047
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-2-6(18-20(13,14)15)5(9)4(8)3(17-6)1-16-19(10,11)12/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4-,5+,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00484 EHMN_ABBREVIATION: C00665
is: CHEBI:58579
initial concentration: 1.0
initial amount: NaN
type: Species
name: beta-D-fructofuranose 2,6-bisphosphate(4-)
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR ACGALtlg
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism - may be vesicular NJ
is described by: ECO:0000000
name: N-acetyl-galactosamine intracellular transport
type: Reaction
reversible: true
product: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000185
kinetic law: MODEL1310110055#

metaM itp c
is: HMDB00189
name: ITP(3-)
has only substance units: false
is: CHEBI:57614
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_metaR_EX_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIA glycolipid exchange
type: Reaction

metaM rib D e
name: D-ribose
is: CHEBI:16988
is: SBO:0000247
is: HMDB00283
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
initial concentration: 1.0
type: Species
initial amount: NaN

metaR FAOXC2252053m
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110055#
product: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000000
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110055#_e9d03586_b279_47a8_b538_b6c1f5709687
has only substance units: false
type: Species
is encoded by: hsa:5224
initial amount: NaN
is: SBO:0000252
constant: false
name: PGAM2
boundary condition: true
initial concentration: NaN

metaM 4ppan c
is: CHEBI:10986
name: D-4'-Phosphopantothenate
boundary condition: false
is: SBO:0000247
is: C03492
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
constant: false
initial concentration: 1.0
is: HMDB01016
type: Species
initial amount: NaN
has only substance units: false

metaR DESAT16 2
modifier: MODEL1310110055#
fast: false
type: Reaction
product: MODEL1310110055#
reversible: false
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
kinetic law: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.19.1
name: palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA)

metaM stcrn c
is: HMDB00848
name: stearoylcarnitine
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
constant: false

metaR CPPPGO
fast: false
notes: GENE_ASSOCIATION: (1371.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.3 Confidence Level: 2 AUTHORS: PMID:8407975 NOTES:r0608, JLR
reactant: MODEL1310110055#
reversible: false
is described by: ECO:0000304
modifier: MODEL1310110055#
name: coproporphyrinogen oxidase (O2 required)
type: Reaction
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.3.3.3
is: SBO:0000176

metaR 5AOPtm
reactant: MODEL1310110055#
product: MODEL1310110055#
fast: false
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10558864 NOTES:NCD. Delta-aminolevulinic acid is produced in mitochondria then converted to PBG in the cytoplasm. Could not find anything on the transporter itself.
is: SBO:0000185
type: Reaction
name: 5-Aminolevulinate mitochondrial transport

metaM gal l
is: CHEBI:12936
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
constant: false
is: HMDB00143
has only substance units: false
name: D-galactose
type: Species

metaM ps hs c
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial concentration: 1.0
is: CHEBI:18303
has only substance units: false
constant: false
name: ps_hs[c]

metaR r1695
fast: false
modifier: MODEL1310110055#
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: false

metaR 4MPTNLtm
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000185
reactant: MODEL1310110055#
reversible: true
name: 4-methylpentanal transport (mitochondria)
type: Reaction
is described by: ECO:0000000

metaR r0381
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
reversible: true
type: Reaction
is: SBO:0000176
reactant: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
product: MODEL1310110055#

metaR URCN
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reversible: false
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/4.2.1.49
fast: false
name: URCN
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_e90a5a98_bb78_4ca7_9649_3496790b06cf
is: SBO:0000252
has only substance units: false
name: TMEM91
initial amount: NaN
type: Species
is: C9JZ62
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:641649

metaM dgdp c
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
initial concentration: 1.0
is: C00361
is: HMDB00960
is: SBO:0000247
boundary condition: false
name: dGDP
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:58595
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_978a1aaa_61f0_4833_b82a_e44f8f660f00
is: Q02742
name: GCNT1
has only substance units: false
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:2650
initial amount: NaN
initial concentration: NaN

metaM rib D c
is: HMDB00283
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:16988
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
type: Species
boundary condition: false
name: D-ribose
has only substance units: false
is: SBO:0000247

metaR DGCHOLtx
name: bile acid intracellular transport
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110055#
is: SBO:0000185
reversible: true
product: MODEL1310110055#

metaR ACCOAgt
is described by: ECO:0000269
kinetic law: MODEL1310110055#
type: Reaction
fast: false
name: acetyl-coa transport
product: MODEL1310110055#
modifier: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_ee66133f_9389_417a_b9c8_c040b7dc8555
name: ACSS1
has only substance units: false
is: Q9NUB1
is encoded by: hsa:84532
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species

metaR GLCNACASE4ly
name: alpha-N-acetylglucosaminidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.50
fast: false
reactant: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
type: Reaction
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_ee74fc4f_e556_4df1_9d91_ffd8eab2b8ba
is encoded by: hsa:4538
initial concentration: NaN
is: SBO:0000252
name: ND4
initial amount: NaN
is: P03905
constant: false
boundary condition: true
has only substance units: false
type: Species

metaR r1693
fast: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110055#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110055#

metaM ksii core4 pre9 g
constant: false
is: CHEBI:28067
has only substance units: false
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 9
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species

metaR AMPDA
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
name: Adenosine monophosphate deaminase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.4.6
reversible: false
is: SBO:0000176
modifier: MODEL1310110055#
type: Reaction
product: MODEL1310110055#

metaM dlnlcg c
is: CHEBI:53486
constant: false
name: dihomo-gamma-linolenic acid (n-6)
type: Species
is: HMDB02925
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_9cf9fdbb_7726_42c1_9a20_32b3bbbdb1c1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: P27707
name: DCK
boundary condition: true
type: Species
is encoded by: hsa:1633
constant: false

metaR GLNTHRNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
type: Reaction
modifier: MODEL1310110055#
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000269
name: L-threonine/L-glutamine Na-dependent exchange (Gln-L in)
fast: false
reactant: MODEL1310110055#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_8cfb0f15_de56_4e5b_94c5_b8f72af2402a
has only substance units: false
is encoded by: hsa:26503
initial amount: NaN
is: Q9NRA2
name: SLC17A5
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_6997c2f5_ac87_4d4f_9779_295f121b5955
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:3945
has only substance units: false
type: Species
name: LDHB
is: P07195

metaR CITtbm
reversible: true
reactant: MODEL1310110055#
is described by: ECO:0000269
name: citrate transport, mitochondrial
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
modifier: MODEL1310110055#
type: Reaction
is: SBO:0000185
product: MODEL1310110055#
kinetic law: MODEL1310110055#

metaR r0384
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
reversible: false
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_9fa01f08_3e6b_413e_9c7a_5f791a308f41
is: SBO:0000252
is encoded by: hsa:2687
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P36269
has only substance units: false
name: GGT5
constant: false

metaR CDPDAGtm
is described by: ECO:0000000
reactant: MODEL1310110055#
name: intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
type: Reaction
product: MODEL1310110055#
reversible: true
kinetic law: MODEL1310110055#
is: SBO:0000185
fast: false

metaR NACHEXA16ly
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110055#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
product: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_6e3205fa_3556_43be_9f87_7eea7f18832a
boundary condition: true
is encoded by: hsa:761
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is: P07451
name: CA3
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_8fce5d55_ffcd_43a8_94e0_32b31c8fd354
boundary condition: true
is: Q76EJ3
initial concentration: NaN
name: SLC35D2
constant: false
type: Species
is encoded by: hsa:11046
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM paps g
constant: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB01134
is: CHEBI:58339
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053

metaM ksii core2 pre1 g
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C33H53N3O23X CHARGE: -1
is: SBO:0000247
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 1
constant: false

metaR GAO2g
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
reactant: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
fast: false
is: SBO:0000176
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110055#
name: Ganglioside O-acetylation
product: MODEL1310110055#

metaM ksi pre17 g
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:28067
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
name: keratan sulfate I biosynthesis, precursor 17

metaM c226crn m
type: Species
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
is: SBO:0000247
boundary condition: false
name: cervonyl carnitine
constant: false
is: HMDB06510
is: http://identifiers.org/pubchem.compound/127055
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR r0617
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110055#
product: MODEL1310110055#
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
kinetic law: MODEL1310110055#
reversible: true

metaM ribflv e
is: SBO:0000247
name: Riboflavin
is: CHEBI:3554
has only substance units: false
initial amount: NaN
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: HMDB00244
constant: false
is: C00255
initial concentration: 1.0
type: Species
boundary condition: false

metaM utp c
name: UTP
is: HMDB00285
has only substance units: false
is: C00075
type: Species
is: CHEBI:46398
constant: false
initial amount: NaN
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaM ksii core4 pre2 g
constant: false
initial concentration: 1.0
notes: FORMULA: C47H76N4O33X CHARGE: -1
initial amount: NaN
boundary condition: false
is: C00130
name: keratan sulfate II boisynthesis, precursor 2
is: CHEBI:58053
has only substance units: false
type: Species
is: HMDB00175
is: SBO:0000247

metaR VLCSr
name: Very-long-chain-fatty-acid-CoA ligase
modifier: MODEL1310110055#
fast: false
type: Reaction
reactant: MODEL1310110055#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
product: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#

metaR S23T4g
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.99.4
reversible: false
modifier: MODEL1310110055#
fast: false
name: beta-galactoside alpha-2,3-sialyltransferase
reactant: MODEL1310110055#

metaR TETDECE1CRNe
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tetradecenoyl carnitine into extra cellular space
type: Reaction

metaR r1676
name: Y+LAT2 Utilized transport
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000000
modifier: MODEL1310110055#
type: Reaction
reversible: false
is: SBO:0000185
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_8f898d9e_7ccb_4cff_8391_3c79b8e86eef
is: SBO:0000252
name: PLCH2
is: O75038
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:9651
has only substance units: false
initial amount: NaN
constant: false

metaR EX glygn5 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 5 (glycogenin-2[1,4-Glc])
type: Reaction

metaR VALt5m
type: Reaction
reversible: true
reactant: MODEL1310110055#
name: Valine reversible mitochondrial transport
product: MODEL1310110055#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110055#_6acb8a3d_e941_4387_98ba_7aff5775b662
is encoded by: hsa:2271
is: P07954
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
name: FH
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR O2tp
product: MODEL1310110055#
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: O2 transport, peroxisomal
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_6787d087_bb09_4863_aad8_23dad98299bb
initial concentration: NaN
is encoded by: hsa:171425
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
type: Species
name: CLYBL
initial amount: NaN

metaR r0616
fast: false
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110055#
product: MODEL1310110055#
kinetic law: MODEL1310110055#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110055#

metaM 34hpp c
is: CHEBI:36242
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
has only substance units: false
initial concentration: 1.0
is: HMDB00707
constant: false
name: 3-(4-hydroxyphenyl)pyruvate
type: Species

metaM acgal l
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
is: HMDB00212
has only substance units: false
type: Species
name: N-acetyl-D-galactosamine
is: CHEBI:28037
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_f6e64835_f6f5_4276_88f2_b7196a9d360a
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5288
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
name: PIK3C2G
is: O75747

metaR RE2677E
fast: false
product: MODEL1310110055#
is: SBO:0000176
reversible: false
reactant: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
kinetic law: MODEL1310110055#
is described by: ECO:0000000
name: RE2677

http://identifiers.org/biomodels.db/MODEL1310110055#_8f6fbdcd_132c_4451_899c_4f174d0c0396
initial concentration: NaN
type: Species
has only substance units: false
name: ATP5D
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:513

metaM co2 x
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
constant: false
name: carbon dioxide
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB01967
has only substance units: false
is: CHEBI:16526
initial amount: NaN
boundary condition: false

metaM ksi deg36 l
type: Species
name: keratan sulfate I, degradation product 36
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00143
initial concentration: 1.0
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
is: CHEBI:12936
is: SBO:0000247

metaM nadp r
initial amount: NaN
is: CHEBI:58349
name: Nicotinamide adenine dinucleotide phosphate
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: SBO:0000247
type: Species
is: C00006
constant: false
initial concentration: 1.0
is: HMDB00217
boundary condition: false
has only substance units: false

metaR CHATn
type: Reaction
reversible: true
is: SBO:0000176
product: MODEL1310110055#
name: Choline O-acetyltransferase
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
modifier: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.6
reactant: MODEL1310110055#

metaR VLCSp
modifier: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
reactant: MODEL1310110055#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
product: MODEL1310110055#
kinetic law: MODEL1310110055#
name: Very-long-chain-fatty-acid-CoA ligase

metaM ribflv c
name: Riboflavin
has only substance units: false
is: SBO:0000247
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: CHEBI:3554
initial amount: NaN
initial concentration: 1.0
is: C00255
boundary condition: false
is: HMDB00244
type: Species
constant: false

metaM dump c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: HMDB01409
name: dUMP
is: C00365
is: CHEBI:246422
initial amount: NaN
boundary condition: false
constant: false

metaR S6TASE22ly
is described by: ECO:0000000
modifier: MODEL1310110055#
name: galactose-6-sulfate sulfatase, lysosomal
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110055#
product: MODEL1310110055#

metaR r1678
product: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110055#
is: SBO:0000185
modifier: MODEL1310110055#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110055#_metaR_EX_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1 exchange
type: Reaction

metaR UGLCNACtg
type: Reaction
modifier: MODEL1310110055#
name: UDP-GlcNAc Golgi transport via CMP antiport
fast: false
is: SBO:0000185
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
reactant: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000269
reversible: true

metaR ASNPHELAT2tc
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Asparagine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM prostgh2 e
name: prostaglandin H2(1-)
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB01381
is: CHEBI:57405
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial amount: NaN
initial concentration: 1.0
type: Species

metaM Ser Gly Ala X Gly l
is: CHEBI:36005
is: HMDB02183
name: protein-linked serine residue (glycosaminoglycan attachment site)
notes: FORMULA: XH CHARGE: 0
type: Species
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR O2tn
product: MODEL1310110055#
fast: false
name: O2 nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
reactant: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110055#

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaR r0618
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
type: Reaction
reactant: MODEL1310110055#
reversible: true
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
product: MODEL1310110055#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110055#
fast: false

metaR O2tm
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
is: SBO:0000185
name: O2 transport (diffusion)
reversible: true
fast: false
type: Reaction
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_0227ac9b_8d73_43b0_adae_a69e3c0ff95f
is encoded by: hsa:1650
has only substance units: false
initial amount: NaN
type: Species
has part: P04844
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:1603
name: DAD1:DDOST:RPN1:RPN2
has part: Q53G02
has part: P39656
is encoded by: hsa:6184
has part: P04843
boundary condition: true
is encoded by: hsa:6185
constant: false

metaM so4 e
has only substance units: false
is: HMDB01448
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: SBO:0000247
name: sulfate
constant: false
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16189

metaM 34hpp e
is: CHEBI:36242
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
is: HMDB00707
constant: false
initial concentration: 1.0
has only substance units: false
name: 3-(4-hydroxyphenyl)pyruvate
type: Species
initial amount: NaN

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_4d1f6f89_0edb_4616_a85b_f5a38ebf55b2
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:8277
initial amount: NaN
initial concentration: NaN
type: Species
name: TKTL1
is: SBO:0000252
is: B7Z7I0

http://identifiers.org/biomodels.db/MODEL1310110055#_fd95733c_0ab2_460a_a1b1_5c918cf7cc45
has only substance units: false
name: COX5B
constant: false
initial concentration: NaN
initial amount: NaN
is: Q53YB7
type: Species
is: SBO:0000252
is encoded by: hsa:1329
boundary condition: true

metaM paps c
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
type: Species
is: HMDB01134
boundary condition: false
has only substance units: false
is: CHEBI:58339
initial amount: NaN

metaR TMDPPK
reversible: false
name: thiamine-diphosphate kinase
is described by: ECO:0000000
kinetic law: MODEL1310110055#
fast: false
type: Reaction
product: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 2.7.6.2 Confidence Level: 2 AUTHORS: PMID:8522961 NOTES:also EC 2.7.6.2 - NCD
is: SBO:0000176

metaR PTPATe
reversible: true
product: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
name: PTPATe
kinetic law: MODEL1310110055#
type: Reaction

metaR RE3079X
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
name: RE3079
reactant: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:11356164 NOTES:IT - fixed proton
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_2f7c78d3_135b_4278_a71c_c891d3ddd1dd
type: Species
name: HAS1
is: Q8IYH3
is encoded by: hsa:3036
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_89e65e5c_1240_4931_b0a6_a9bbca297f64
is: SBO:0000252
is encoded by: hsa:23396
constant: false
type: Species
name: PIP5K1C
is: O60331
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM estradiol c
is: HMDB00151
boundary condition: false
name: estradiol
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
is: SBO:0000247
is: CHEBI:16469
has only substance units: false
initial concentration: 1.0

metaR EX CE2250 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-oxodocosanoyl-CoA exchange
type: Reaction

metaR AG13T1g
type: Reaction
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000176
kinetic law: MODEL1310110055#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaR NTP3e
reversible: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
product: MODEL1310110055#
is: SBO:0000176
modifier: MODEL1310110055#
fast: false
type: Reaction
is described by: ECO:0000269
name: nucleoside-triphosphatase (GTP)
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.6.1.6

metaR r0086
is version of: http://identifiers.org/ec-code/3.5.1.3
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
product: MODEL1310110055#
reactant: MODEL1310110055#
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000176

metaM idp c
is: CHEBI:58280
name: IDP(3-)
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB03335
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
has only substance units: false
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_530996c2_ccdc_4787_9e50_3fed982bf437
is encoded by: hsa:221823
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P21108
is: SBO:0000252
has only substance units: false
type: Species
name: PRPS1L1

metaM dmhptcrn e
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB06320
has only substance units: false
name: 2,6 dimethylheptanoyl carnitine
constant: false

metaM dhcholestancoa r
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
is: HMDB02159
is: CHEBI:15494
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
is: SBO:0000247
type: Species

metaM dag hs c
is: CHEBI:18035
type: Species
constant: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
name: diglyceride
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM prostgh2 c
is: SBO:0000247
boundary condition: false
is: CHEBI:57405
initial concentration: 1.0
is: HMDB01381
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
has only substance units: false
initial amount: NaN
type: Species
name: prostaglandin H2(1-)

metaR ASPTA
product: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
type: Reaction
kinetic law: MODEL1310110055#
name: aspartate transaminase
modifier: MODEL1310110055#
reversible: true
is: SBO:0000176
reactant: MODEL1310110055#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.1

metaM so4 c
initial amount: NaN
name: sulfate
is: SBO:0000247
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false
has only substance units: false
is: CHEBI:16189
type: Species
initial concentration: 1.0
is: HMDB01448
boundary condition: false

metaM gpi prot hs r
is: C00249
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2X CHARGE: 0
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:7896
is: HMDB00220
name: {[(Prot-PE-Man),(PE)-Man],[PE]}-Man-GlcN-acylPI

metaR CYANt
product: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
is: SBO:0000185
name: Cyanide transport via diffusion (extracellular to cytosol)
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
is described by: ECO:0000000
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_c1403f63_4bdd_485b_a985_00e6937b4cb2
has only substance units: false
type: Species
is encoded by: hsa:515
name: ATP5F1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_4d1aeb0f_9693_4243_950c_7e8194b27128
has only substance units: false
name: DGUOK
is: E5KSL5
is encoded by: hsa:1716
type: Species
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252

metaR ACOAD8m
reversible: false
reactant: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.3.99.10
notes: GENE_ASSOCIATION: (3712.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 4 AUTHORS: PMID:9214289 NOTES:MM
is described by: ECO:0000269
fast: false
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial
product: MODEL1310110055#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110055#_9dfb7f2e_30ec_4fc2_bdb2_eee46d82e477
is: Q9H553
type: Species
constant: false
has only substance units: false
name: ALG2
initial concentration: NaN
boundary condition: true
is encoded by: hsa:85365
initial amount: NaN
is: SBO:0000252

metaR EX hpdca LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptadecanoate exchange
type: Reaction

metaR IVCRNe
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of isovaleryl carnitine into the extra cellular space
type: Reaction

metaR DNDPt24m
fast: false
reactant: MODEL1310110055#
product: MODEL1310110055#
name: dTDP transport via dADP antiport
modifier: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269

metaR DOLASNT Ler
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (liver)
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.4.1.119
is described by: ECO:0000000
product: MODEL1310110055#
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110055#
is: SBO:0000176

metaR FAOXC161802m
reversible: false
type: Reaction
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110055#
is: SBO:0000176
name: Beta oxidation fatty acid
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.3.8.1

metaM ksi deg23 l
type: Species
name: keratan sulfate I, degradation product 23
is: CHEBI:12936
initial concentration: 1.0
constant: false
is: HMDB00143
boundary condition: false
has only substance units: false
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_8a02522c_1d55_47bf_9c82_7c97b0b956be
initial amount: NaN
is: P35475
constant: false
is encoded by: hsa:3425
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
name: IDUA

metaR r0196
product: MODEL1310110055#
reversible: true
type: Reaction
is described by: ECO:0000000
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
modifier: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110055#_0c803812_0103_46cc_a866_a9075cad1dfa
type: Species
initial amount: NaN
is encoded by: hsa:6568
constant: false
name: SLC17A1
is: Q14916
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR CITtam
type: Reaction
reactant: MODEL1310110055#
is described by: ECO:0000269
name: citrate transport, mitochondrial
product: MODEL1310110055#
reversible: true
fast: false
kinetic law: MODEL1310110055#
is: SBO:0000185
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF

http://identifiers.org/biomodels.db/MODEL1310110055#_0b8ddb68_6975_4627_9810_de3d38714f86
name: AKR1A1
is encoded by: hsa:10327
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is: P14550
initial concentration: NaN

metaR G14T20g
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
is: SBO:0000176
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
product: MODEL1310110055#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_4d310c0c_bf1c_43cf_b0f9_8db12318336f
initial amount: NaN
is encoded by: hsa:AI684467
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: _AI684467_1_m
boundary condition: true
constant: false

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaM utp e
initial concentration: 1.0
is: SBO:0000247
is: HMDB00285
is: CHEBI:46398
initial amount: NaN
name: UTP(4-)
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
type: Species
boundary condition: false
constant: false
has only substance units: false

metaM psyltchol e
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB11178
boundary condition: false
initial amount: NaN
notes: FORMULA: C9642032H15428745NO8667421S CHARGE: 0
name: psyllium-taurocholic acid complex

http://identifiers.org/biomodels.db/MODEL1310110055#_83d64052_9e4d_4b29_8ec1_7ee4b10f4d3f
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8525
has only substance units: false
is: B7Z6M3
name: DGKZ
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_96ee8d2a_c57d_470f_b64d_dd0eeb3e38fb
has part: P42336
has part: O00459
has only substance units: false
is encoded by: hsa:5296
constant: false
type: Species
initial amount: NaN
name: PIK3CA:PIK3R2
initial concentration: NaN
is encoded by: hsa:5290
is: SBO:0000297
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_f2cec43e_b12f_45ec_926d_c25b362693ec
constant: false
name: ST3GAL5
is: SBO:0000252
is: Q9UNP4
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:8869

metaM eicostetcrn m
is: CHEBI:57312
is: SBO:0000247
type: Species
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB01356
has only substance units: false
initial amount: NaN
name: Eicosatetranoyl carnitine

metaR GLYt4
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000269
reversible: false
product: MODEL1310110055#
reactant: MODEL1310110055#
name: glycine transport via sodium symport
fast: false
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB irreversible
type: Reaction
is: SBO:0000185

metaM gthrd c
has only substance units: false
is: CHEBI:57925
name: Reduced glutathione
is: C00051
type: Species
is: HMDB00125
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: SBO:0000247

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaR HISCAT1
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaR DHFR
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
name: dihydrofolate reductase
modifier: MODEL1310110055#
is described by: ECO:0000254
reversible: true
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176
product: MODEL1310110055#
reactant: MODEL1310110055#

metaR PIACGT
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.4.1.83
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.4.1.198
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
reversible: false
fast: false
type: Reaction
name: phosphatidylinositol N-acetylglucosaminyltransferase

metaM ivcoa m
name: Isovaleryl-CoA
is: CHEBI:57345
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
boundary condition: false
constant: false
is: HMDB01113

http://identifiers.org/biomodels.db/MODEL1310110055#_2d318144_eea3_40ac_bd6c_e1f47211caf0
has only substance units: false
is: Q9Y5L3
initial concentration: NaN
name: ENTPD2
constant: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:954
initial amount: NaN

metaM eicostetcrn c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
name: Eicosatetranoyl carnitine
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:57312
constant: false
is: HMDB01356

metaR 34DHPLACOX NADP
product: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
reversible: true
name: 3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase
modifier: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (222.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.2.1.5

http://identifiers.org/biomodels.db/MODEL1310110055#_52f862d9_07eb_4a34_8c5f_886899c4a70f
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: Q9HAB8
boundary condition: true
is encoded by: hsa:79717
name: PPCS
initial concentration: NaN

metaR NACHEXA9ly
is described by: ECO:0000000
modifier: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
fast: false
name: beta-N-acetylhexosaminidase A, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is: SBO:0000176

metaR FACOAL150
reactant: MODEL1310110055#
name: fatty-acid--CoA ligase
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
is: SBO:0000176
reversible: true
modifier: MODEL1310110055#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110055#
is described by: ECO:0000000

metaR NDP8
kinetic law: MODEL1310110055#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.4.9
modifier: MODEL1310110055#
is: SBO:0000176
type: Reaction
product: MODEL1310110055#
is described by: ECO:0000269
name: nucleoside-diphosphatase (dUDP)

http://identifiers.org/biomodels.db/MODEL1310110055#_62371a5d_f8cf_4eac_bf01_8d05606e9335
initial concentration: NaN
is encoded by: hsa:29920
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q96C36
name: PYCR2

metaR DCK1n
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
name: Deoxycytidine kinase, nuclear (ATP)
is: SBO:0000176
reversible: true
product: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.74
is described by: ECO:0000269

metaM taur e
has only substance units: false
is: HMDB00251
notes: FORMULA: C2H7NO3S CHARGE: 0
is: C00245
boundary condition: false
initial concentration: 1.0
constant: false
name: Taurine
is: CHEBI:3544
initial amount: NaN
type: Species
is: SBO:0000247

metaR CRNrtx
type: Reaction
product: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
is described by: ECO:0000134
is: SBO:0000185
name: reversible transport of L-Carnitine in peroxisome
reversible: true
reactant: MODEL1310110055#

metaR ESTRADIOLt
type: Reaction
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110055#
is: SBO:0000185
fast: false
name: estradiol transport

metaM gthrd e
type: Species
is: HMDB00125
boundary condition: false
is: CHEBI:57925
name: glutathionate(1-)
constant: false
has only substance units: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR CYTK12n
is: SBO:0000176
name: cytidylate kinase (dCMP,dCTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reversible: true
type: Reaction
modifier: MODEL1310110055#
is described by: ECO:0000269
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM ivcoa c
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
name: Isovaleryl-CoA
constant: false
is: HMDB01113
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false

metaM nadp m
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: C00006
is: HMDB00217
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate
constant: false
type: Species
is: CHEBI:58349

http://identifiers.org/biomodels.db/MODEL1310110055#_3b65f6b8_6cac_4a73_a7b6_b98354193e8f
initial amount: NaN
type: Species
is: E9PB82
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3295
has only substance units: false
name: HSD17B4
constant: false
initial concentration: NaN

metaM T antigen g
has only substance units: false
notes: FORMULA: C14H24NO10X CHARGE: 0
initial amount: NaN
is: CHEBI:22783
is: SBO:0000247
boundary condition: false
name: T antigen (core 1)
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_ac2a18a4_6631_413a_892a_ea1887fe5525
name: HADHB
is encoded by: hsa:3032
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: P55084
boundary condition: true
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_ad886840_14a4_42ff_9abc_c11b6161eacf
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: FADS2
is: O95864
initial concentration: NaN
is encoded by: hsa:9415

metaM so4 l
is: HMDB01448
name: sulfate
is: SBO:0000247
initial amount: NaN
is: CHEBI:16189
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false
has only substance units: false

metaR OLEICFATPtc
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_d45bfe24_9d0d_43d3_b1e3_2dd48738ad1b
is: Q16854
initial amount: NaN
type: Species
is encoded by: hsa:1716
boundary condition: true
initial concentration: NaN
name: DGUOK
has only substance units: false
is: SBO:0000252
constant: false

metaR BAAT4x
is described by: ECO:0000304
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:fourth version analog added in similarity to BAAT1x, BAAT2x NJ
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176
name: bile acid Coenzyme A: amino acid N-acyltransferase
type: Reaction
fast: false
reversible: false
product: MODEL1310110055#

metaM octdececrn m
has only substance units: false
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
constant: false
boundary condition: false
notes: FORMULA: C25H47NO4 CHARGE: 0
initial amount: NaN
type: Species
is: HMDB06351
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_39d9725e_0ba9_428f_b2ba_8eae3c44d35e
initial concentration: NaN
is: SBO:0000252
name: _H77542_1_c
has only substance units: false
type: Species
constant: false
is encoded by: hsa:H77542
initial amount: NaN
boundary condition: true

metaM taur c
constant: false
initial amount: NaN
is: HMDB00251
initial concentration: 1.0
notes: FORMULA: C2H7NO3S CHARGE: 0
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:3544
name: Taurine
is: C00245

metaR RE1516M
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.13
reversible: true
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE1516
reactant: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000000
fast: false
type: Reaction

metaR RE0926E
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.1
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
modifier: MODEL1310110055#
product: MODEL1310110055#
fast: false
type: Reaction
is described by: ECO:0000000
name: RE0926
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110055#_2882dca9_624e_472a_9187_a33aaff0c4a8
type: Species
constant: false
has only substance units: false
is: B4DIA3
boundary condition: true
name: SLC6A8
initial amount: NaN
is encoded by: hsa:6535
initial concentration: NaN
is: SBO:0000252

metaR ICDHyrm
reversible: true
is described by: ECO:0000269
name: Isocitrate dehydrogenase (NADP+)
is version of: http://identifiers.org/ec-code/1.1.1.42
modifier: MODEL1310110055#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF

metaM so4 m
name: sulfate
boundary condition: false
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01448
is: CHEBI:16189
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_193fd36f_cee3_4043_9e26_1e13a192df89
boundary condition: true
is encoded by: hsa:10786
is: SBO:0000252
is: O00476
initial concentration: NaN
initial amount: NaN
type: Species
name: SLC17A3
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_a38a9d1b_46f7_4d9a_a0ac_1fb8872a9bf7
has only substance units: false
type: Species
is: SBO:0000252
constant: false
is: O94777
name: DPM2
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8818
boundary condition: true

metaM HC02204 e
is: SBO:0000247
initial amount: NaN
is: CHEBI:27624
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
constant: false
type: Species
has only substance units: false
name: prostaglandin-b1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_0e9f1791_0e9a_441d_ba02_5b1663846a16
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:25902
initial concentration: NaN
has only substance units: false
constant: false
is: B2RD24
initial amount: NaN
name: MTHFD1L

metaM dmhptcrn c
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
is: SBO:0000247
has only substance units: false
is: HMDB06320
constant: false
name: 2,6 dimethylheptanoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110055#_c7729cd1_6bd9_4ef9_b2c3_e59e6f87e0cb
is: P00813
name: ADA
type: Species
is: SBO:0000252
is encoded by: hsa:100
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN

metaM HC01361 e
is: CHEBI:17001
is: SBO:0000247
notes: FORMULA: C9H13N5O4 CHARGE: 0 INCHI: InChI=1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1 EHMN_ABBREVIATION: C04874
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
name: Dihydroneopterin
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_74384712_3081_4b8c_b168_b0d48da50616
has only substance units: false
is encoded by: hsa:123041
boundary condition: true
initial amount: NaN
name: SLC24A4
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_0f489a7f_2240_46ef_8c31_3ff5adc89842
constant: false
initial concentration: NaN
name: _M68895_1_c
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:M68895

metaR DNDPt35m
kinetic law: MODEL1310110055#
fast: false
is: SBO:0000185
reversible: false
name: dGDP transport via dADP antiport
reactant: MODEL1310110055#
product: MODEL1310110055#
modifier: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269

metaM sebcoa x
initial amount: NaN
initial concentration: 1.0
name: sebacoylcoa
type: Species
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966

http://identifiers.org/biomodels.db/MODEL1310110055#_9de276fd_1350_4240_bc82_4ffce00dd300
is: O14561
boundary condition: true
is encoded by: hsa:4706
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
name: NDUFAB1

metaR G14T13g
fast: false
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
product: MODEL1310110055#
is described by: ECO:0000000
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176

metaR MAL Lte
reactant: MODEL1310110055#
fast: false
product: MODEL1310110055#
type: Reaction
name: Transport of L-malate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110055#
is: SBO:0000185
is described by: ECO:0000134
reversible: true

metaM na1 c
initial concentration: 1.0
type: Species
notes: FORMULA: Na CHARGE: 1
is: HMDB00588
constant: false
is: C01330
initial amount: NaN
is: CHEBI:4541
has only substance units: false
boundary condition: false
is: SBO:0000247
name: Sodium

metaR r1567
is: SBO:0000185
product: MODEL1310110055#
reactant: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110055#

metaM 4izp c
constant: false
has only substance units: false
type: Species
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
is: HMDB01014
name: 4-Imidazolone-5-propanoate
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:57255

metaR PI34P5K
product: MODEL1310110055#
modifier: MODEL1310110055#
reversible: false
type: Reaction
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
reactant: MODEL1310110055#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.68
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_4b0495f4_96f0_456b_a8e2_48118d31a2ec
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:23057
name: NMNAT2
has only substance units: false
constant: false
type: Species
is: SBO:0000252

metaR GMPR
is version of: http://identifiers.org/ec-code/1.7.1.7
name: GMP reductase
modifier: MODEL1310110055#
type: Reaction
product: MODEL1310110055#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
kinetic law: MODEL1310110055#
is: SBO:0000176
reversible: false

metaM CE5120 m
initial concentration: 1.0
is: CHEBI:57923
has only substance units: false
type: Species
constant: false
boundary condition: false
name: trans-2-cis-8-tetradecadienoyl-CoA
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
initial amount: NaN
is: SBO:0000247

metaM sebacid x
constant: false
is: HMDB00792
is: C08277
name: sebacicacid
type: Species
boundary condition: false
notes: FORMULA: C10H16O4 CHARGE: -2
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_8b9bb852_b12c_444a_835b_7360b77054cf
constant: false
initial concentration: NaN
name: _D29675_1_c
is: SBO:0000252
is encoded by: hsa:D29675
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true

metaR AASAD3m
kinetic law: MODEL1310110055#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15865210 NOTES:MM. Found under reaction synonym name: 2-aminoadipic 6-semialdehyde dehydrogenase; Evidence was from mouse with identification of good human ortholog for U26 in the mouse that catalyzes this reaction. There was NOT evidence here specific to mitochondria, though. (Nathan Price)
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110055#
fast: false
name: L-aminoadipate-semialdehyde dehydrogenase (NADH), mitochondrial
reactant: MODEL1310110055#

metaR ASCBt4
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
name: L-ascorbate transport via proton symport
is described by: ECO:0000269
modifier: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000185
type: Reaction
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_162307a6_fcba_4f08_a707_d5acc0718b4f
is: B3KNC1
is encoded by: hsa:51733
initial concentration: NaN
type: Species
name: UPB1
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false

metaM HC02204 c
is: CHEBI:27624
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
name: prostaglandin-b1
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_7872f99a_76b4_4445_bc68_7b047c0909d0
constant: false
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q6ZWP6
name: ACAD8
is encoded by: hsa:27034

http://identifiers.org/biomodels.db/MODEL1310110055#_6e0b9c21_db6d_4f1d_b1ed_60056ceb5822
has only substance units: false
is encoded by: hsa:57678
initial concentration: NaN
name: GPAM
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is: Q8N1G6

http://identifiers.org/biomodels.db/MODEL1310110055#_3c4648ff_be4d_4c52_bc76_a5080d4f2882
boundary condition: true
is: O75752
name: B3GALNT1
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:8706

metaM ksii core2 deg2 l
type: Species
is: CHEBI:12936
initial concentration: 1.0
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
is: HMDB00143
name: keratan sulfate II (core 2-linked), degradation product 2
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false

metaR r1568
fast: false
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110055#
reactant: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110055#_4912a581_28a5_4e55_acc3_8a9fcb916f4c
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q5SPY7
name: ENTPD2
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:954

http://identifiers.org/biomodels.db/MODEL1310110055#_1284b979_d29b_40fc_9efb_4c18f10eaa0a
name: NT5C2
boundary condition: true
initial amount: NaN
is: P49902
type: Species
is encoded by: hsa:22978
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_09127123_7864_48a6_9492_6fd6f685f215
is encoded by: hsa:4712
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
name: NDUFB6
constant: false
is: SBO:0000252
has only substance units: false
is: O95139

metaR GTHDH
is described by: ECO:0000134
product: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
type: Reaction
name: Glutathione dehydrogenase (dehydroascorbate reductase)

metaM sucsal m
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB01259
is: SBO:0000247
is: CHEBI:57706
constant: false
name: Succinic semialdehyde

metaR AHC
is: SBO:0000176
modifier: MODEL1310110055#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.3.1.1
fast: false
reversible: true
reactant: MODEL1310110055#
name: adenosylhomocysteinase
notes: GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
kinetic law: MODEL1310110055#

metaR B3GNT311g
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
type: Reaction
reactant: MODEL1310110055#
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000254
product: MODEL1310110055#
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_c0db6f49_2571_4208_9b0f_26c1b14487dd
initial concentration: NaN
initial amount: NaN
name: NDUFV2
is: P19404
is encoded by: hsa:4729
has only substance units: false
is: SBO:0000252
type: Species
constant: false
boundary condition: true

metaR NDPK10n
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
is described by: ECO:0000304
product: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
reversible: true
modifier: MODEL1310110055#
reactant: MODEL1310110055#

metaR DURIK1
is: SBO:0000176
kinetic law: MODEL1310110055#
reversible: false
modifier: MODEL1310110055#
fast: false
name: deoxyuridine kinase (ATP:Deoxyuridine)
is described by: ECO:0000254
type: Reaction
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.1.21
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:
reactant: MODEL1310110055#

metaR DECDICRNe
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of decadienoyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_e
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
boundary condition: false
is: HMDB00660
is: C00095
type: Species
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:15824

metaR r1569
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
product: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#

metaM na1 e
name: Sodium
initial concentration: 1.0
notes: FORMULA: Na CHARGE: 1
is: HMDB00588
constant: false
initial amount: NaN
is: C01330
is: CHEBI:4541
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species

metaR UDPGALtg
is described by: ECO:0000269
modifier: MODEL1310110055#
type: Reaction
is: SBO:0000185
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
fast: false
reversible: true
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
name: UDP-Gal Golgi transport via CMP antiport

metaR GULLACter
is described by: ECO:0000000
fast: false
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: false
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES:NCD
is: SBO:0000185
name: gulonolactone endoplasmic reticular transport
type: Reaction

metaR ADAe
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.4.4
kinetic law: MODEL1310110055#
name: Adenosine deaminase, extracellular
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
modifier: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
type: Reaction
product: MODEL1310110055#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_1a53b4bf_fd1f_419c_a802_eb2489edf56e
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false
name: PIP4K2B
is: P78356
is encoded by: hsa:8396
initial amount: NaN
has only substance units: false

metaM dhcholestanate x
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00359
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:16577

http://identifiers.org/biomodels.db/MODEL1310110055#_ea96fa47_227e_45d9_8010_7460dfd6f395
initial concentration: NaN
name: CROT
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:54677
is: E7EQF2
constant: false
is: SBO:0000252
type: Species

metaM c226crn c
name: cervonyl carnitine
is: HMDB06510
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/127055
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+

metaM m7mpdol L r
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C1720H2828N20O570P20 CHARGE: -20
is: CHEBI:37636
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog

metaM prist x
type: Species
is: HMDB00795
constant: false
initial concentration: 1.0
name: pristanic acid
is: SBO:0000247
is: CHEBI:51340
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)

http://identifiers.org/biomodels.db/MODEL1310110055#_e5bf54f2_d875_4c2d_b5ae_881a6ba690d3
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: _AI769281_1_e
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:AI769281
type: Species

metaM nm2masn g
boundary condition: false
initial amount: NaN
constant: false
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
has only substance units: false
is: C05884
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C42H70N3O30X CHARGE: 0
type: Species

metaM prpncoa m
is: HMDB02307
has only substance units: false
type: Species
is: CHEBI:57367
is: SBO:0000247
constant: false
name: acryloyl-CoA(4-)
boundary condition: false
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_1959438d_2a6f_41b7_aaf4_8a163fa13eda
initial amount: NaN
is encoded by: hsa:AI469183
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
name: _AI469183_1_x
boundary condition: true

metaM i e
initial amount: NaN
is: SBO:0000247
name: iodide
initial concentration: 1.0
boundary condition: false
is: CHEBI:16382
has only substance units: false
constant: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
type: Species
is: HMDB12238

metaR FAOXC61C4x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
is: HMDB00174
is: CHEBI:18287
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247

metaR PROt2r
name: L-proline reversible transport via proton symport
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110055#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
modifier: MODEL1310110055#
reversible: true
product: MODEL1310110055#
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_541f95cf_61ac_4865_b1e6_40fb54b7d977
initial concentration: NaN
type: Species
name: CHKB
is: SBO:0000252
is: Q9Y259
constant: false
is encoded by: hsa:1120
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_cf61293e_2841_4de3_b964_fde909aaf7e5
is: Q9NRR6
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
name: INPP5E
is encoded by: hsa:56623
constant: false
has only substance units: false
initial concentration: NaN

metaM i c
boundary condition: false
is: HMDB12238
type: Species
is: SBO:0000247
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
has only substance units: false
initial amount: NaN
is: CHEBI:16382
name: iodide
constant: false
initial concentration: 1.0

metaM glc D c
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: D-glucose
is: SBO:0000247
is: CHEBI:4167
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
constant: false
has only substance units: false
is: HMDB00122

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_3a82b3bd_83f2_42c1_a175_c2160f7f5767
name: CEPT1
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:10390
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: B3KN25

http://identifiers.org/biomodels.db/MODEL1310110055#_b3f36504_138a_4de2_bac7_c53792d70fd7
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
name: CHST5
is encoded by: hsa:23563

metaR ACt2r
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
is described by: ECO:0000000
name: acetate reversible transport via proton symport
kinetic law: MODEL1310110055#
reversible: true
reactant: MODEL1310110055#

metaR MDRPD
is described by: ECO:0000000
reactant: MODEL1310110055#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:JLR- Based on reaction given for B. subtilis (Sekowska A and A. Danchin paper(2002) )
name: 5-Methylthio-5-deoxy-D-ribulose 1-phosphate dehydratase
product: MODEL1310110055#
fast: false
type: Reaction
kinetic law: MODEL1310110055#
is: SBO:0000176

metaR r1576
kinetic law: MODEL1310110055#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
reactant: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaR THYOXt2
type: Reaction
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110055#
modifier: MODEL1310110055#
fast: false
reversible: true
kinetic law: MODEL1310110055#
product: MODEL1310110055#
name: T4 transport via facilitated diffusion

metaM dag hs n
initial concentration: 1.0
name: diglyceride
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
has only substance units: false
is: SBO:0000247
is: CHEBI:18035
constant: false
initial amount: NaN
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_918c69cc_aeda_4284_b36f_71f95262c739
is: SBO:0000252
has only substance units: false
is: Q75T13
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:80055
type: Species
name: PGAP1

metaR r1575
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000000

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_8fa03b10_afa8_4568_9ee4_61d6c2d3f420
is: Q9P212
has only substance units: false
boundary condition: true
is encoded by: hsa:51196
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
name: PLCE1

http://identifiers.org/biomodels.db/MODEL1310110055#_7bbd4630_908b_47c5_ad06_4892c3377bd9
is: P30838
boundary condition: true
name: ALDH3A1
is encoded by: hsa:218
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN

metaR r2506
name: Utilized transport
product: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_e22de051_6986_42da_a06b_e4270e08e875
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:3099
is: P52789
name: HK2
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN

metaM gbside hs g
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
name: globoside
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
initial amount: NaN
is: CHEBI:18259
constant: false

metaR S6T10g
modifier: MODEL1310110055#
type: Reaction
fast: false
reactant: MODEL1310110055#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110055#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaM octdececrn c
boundary condition: false
has only substance units: false
is: HMDB06351
initial amount: NaN
notes: FORMULA: C25H47NO4 CHARGE: 0
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR r1789
product: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: false
reactant: MODEL1310110055#
fast: false
is: SBO:0000185
type: Reaction
name: Y+LAT2 Utilized transport
modifier: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM idp n
constant: false
initial concentration: 1.0
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
name: IDP(3-)
boundary condition: false
is: CHEBI:58280
is: HMDB03335

http://identifiers.org/biomodels.db/MODEL1310110055#_571d2130_655f_415d_8b9f_5bab73780ca0
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:HG2846-HT2983
has only substance units: false
type: Species
name: _HG2846_HT2983_1_c
is: SBO:0000252
constant: false

metaR r2408
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110055#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
product: MODEL1310110055#
reversible: false
fast: false
reactant: MODEL1310110055#
is: SBO:0000185
is described by: ECO:0000000

metaR S6T3g
is version of: http://identifiers.org/ec-code/2.8.2.21
reversible: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.17
product: MODEL1310110055#
kinetic law: MODEL1310110055#

metaR r1453
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
product: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#

metaR PPNCL3
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
type: Reaction
name: phosphopantothenate-cysteine ligase
is version of: http://identifiers.org/ec-code/6.3.2.5
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110055#

metaR 4ABUTtcn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: Jane D. Carver, W. Allan Walkera , The Journal of Nutritional Biochemistry, Volume 6, Issue 2, February 1995, Pages 58?72. NOTES:added during gap-filling, required for GABA role in cell proliferation.
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
name: transport of GABA
reversible: false
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110055#

metaM gdpddman c
is: HMDB01346
initial concentration: 1.0
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
constant: false
is: CHEBI:57964
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222

metaM ksii core4 pre10 g
has only substance units: false
is: SBO:0000247
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
initial concentration: 1.0
type: Species
is: CHEBI:28067
constant: false
name: keratan sulfate II biosynthesis, precursor 10
boundary condition: false
initial amount: NaN

metaM ksi pre4 g
has only substance units: false
notes: FORMULA: C101H165N7O72X CHARGE: -1
boundary condition: false
is: SBO:0000247
is: CHEBI:58053
constant: false
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 4
initial amount: NaN
is: C00130
initial concentration: 1.0
type: Species

metaM arachcoa m
initial amount: NaN
constant: false
initial concentration: 1.0
name: arachidyl coenzyme A
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: SBO:0000247
is: HMDB04258
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:15527

metaR FAOXC165C164x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:5-->C16:4)x
type: Reaction

metaR r1578
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
reactant: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#
type: Reaction

metaM pacald c
constant: false
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
name: phenylacetaldehyde
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB06236
is: SBO:0000247
boundary condition: false
is: CHEBI:16424

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_db852815_6451_4d94_82f7_9648e244b127
is: Q9Y2P5
is encoded by: hsa:10998
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: SLC27A5
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_768ba5fa_154a_4c49_a2fc_57ad6fd0835b
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: P37268
is: SBO:0000252
name: FDFT1
is encoded by: hsa:2222
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_2e84a346_72d6_4c7d_92f8_a2edfc20dfec
is: SBO:0000252
constant: false
type: Species
is: A8K0S7
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
name: SLC37A4
is encoded by: hsa:2542

http://identifiers.org/biomodels.db/MODEL1310110055#_110b6054_0c11_4013_8dd3_1c0a992b6378
has only substance units: false
name: HSD17B8
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:7923
initial amount: NaN
is: Q92506
type: Species

metaR O2t
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
name: o2 transport (diffusion)
is described by: ECO:0000000
product: MODEL1310110055#

metaM gbside hs e
initial concentration: 1.0
has only substance units: false
name: globoside
boundary condition: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
type: Species
is: SBO:0000247
is: CHEBI:18259
initial amount: NaN
constant: false

metaR PHYTt
product: MODEL1310110055#
name: fatty acid transport via diffusion
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110055#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction

metaM hdd2coa x
boundary condition: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
initial amount: NaN
initial concentration: 1.0
name: (E)-hexadec-2-enoyl-CoA(4-)
type: Species
constant: false
has only substance units: false
is: CHEBI:61526
is: HMDB03945
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_ea221485_6101_44f8_8428_fb0865ae27ba
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
is: P15289
initial concentration: NaN
is encoded by: hsa:410
name: ARSA

metaR ACNMLr
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 4.1.3.3 Confidence Level: 2 AUTHORS: NOTES:JLR
kinetic law: MODEL1310110055#
is described by: ECO:0000000
name: N-Acetylneuraminate lyase (reversible)
fast: false
product: MODEL1310110055#
is: SBO:0000176
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_0fdd697f_5292_451c_a1e7_0d43b907bea3
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: ATP5J
is encoded by: hsa:522

metaR GASNASE2ly
is version of: http://identifiers.org/ec-code/3.5.1.26
modifier: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000176
name: glycosylasparaginase, lysosomal
kinetic law: MODEL1310110055#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
reversible: false

metaR PEAMNO
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
reactant: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.22
is version of: http://identifiers.org/ec-code/1.4.3.4
is described by: ECO:0000304
name: Phenethylamine oxidase
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.21
reversible: false
product: MODEL1310110055#
modifier: MODEL1310110055#
is: SBO:0000176
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_4279498c_6bb7_41cf_9e9f_8de69f13b55b
constant: false
has only substance units: false
initial concentration: NaN
name: AK4
is: P27144
is: SBO:0000252
is encoded by: hsa:205
initial amount: NaN
type: Species
boundary condition: true

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

metaR GUAt
reversible: true
fast: false
reactant: MODEL1310110055#
name: Guanine transport
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110055#_a105defc_34f8_44ab_bb56_87261fb6d747
is: SBO:0000252
is encoded by: hsa:4245
is: P26572
initial amount: NaN
name: MGAT1
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
type: Species

metaM ttdcrn c
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB05066
name: tetradecanoyl carnitine
boundary condition: false
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3413344
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
initial amount: NaN

metaR GASNASE3ly
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.26
modifier: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
name: glycosylasparaginase, lysosomal
is: SBO:0000176
product: MODEL1310110055#
reversible: false

metaR SPHS1Pte
is: SBO:0000185
reversible: true
product: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
kinetic law: MODEL1310110055#
is described by: ECO:0000000
fast: false
type: Reaction
name: sphingosine-1-phosphate transport

http://identifiers.org/biomodels.db/MODEL1310110055#_f7eb5c83_1252_4409_a02f_f86cad9bf4a6
has only substance units: false
constant: false
is: Q9NY97
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10678
name: B3GNT2
is: SBO:0000252
boundary condition: true
type: Species

metaM dag hs r
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: diglyceride
boundary condition: false
is: CHEBI:18035
type: Species
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_0d459d4d_28d1_4ca6_88ef_7093d2b4c536
initial concentration: NaN
constant: false
is: O00483
type: Species
name: NDUFA4
has only substance units: false
is encoded by: hsa:4697
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR r1454
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:

metaM adrncrn m
is: C00318
is: SBO:0000247
name: Adrenyl carnitine
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C29H49NO4 CHARGE: 0
is: HMDB00062
type: Species
is: CHEBI:16347
initial concentration: 1.0

metaR CYStec
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000269
name: L-cysteine transport via diffusion (extracellular to cytosol)
product: MODEL1310110055#
fast: false
modifier: MODEL1310110055#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14624363,PMID:15659399 NOTES:SAB
is: SBO:0000185

metaR r1571
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110055#
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_7a08a8f9_b0d9_4a5c_89c9_7e37537b6eda
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:56894
constant: false
type: Species
name: AGPAT3

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_93092a95_4d70_48ed_9b20_5fa6b371e4ac
boundary condition: true
is: P48201
is encoded by: hsa:518
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: ATP5G3

http://identifiers.org/biomodels.db/MODEL1310110055#_65c7a69d_468f_48bc_8829_5b227cca5232
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
name: ALDOA
constant: false
boundary condition: true
is encoded by: hsa:226
has only substance units: false

metaR BILIRUBt2
kinetic law: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
name: bilirubin transport via bicarbonate countertransport
type: Reaction
product: MODEL1310110055#
reactant: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000269
reversible: true
fast: false

metaR GLYt7 211 r
name: glycine reversible transport via sodium and chloride symport (2:1:1)
fast: false
product: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110055#
is: SBO:0000185
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000269
type: Reaction

metaM gbside hs c
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:18259
name: globoside
constant: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
initial concentration: 1.0

metaM dhcholestanate r
type: Species
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: SBO:0000247
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
initial amount: NaN
is: HMDB00359
has only substance units: false
initial concentration: 1.0
is: CHEBI:16577
boundary condition: false

metaM retinal c
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:15035
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
constant: false
initial amount: NaN
initial concentration: 1.0
name: retinal
is: HMDB01358

metaR PIPLCn
product: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.4.11
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
reversible: false
type: Reaction
kinetic law: MODEL1310110055#
is: SBO:0000176
modifier: MODEL1310110055#
name: phosphatidylinositol phospholipase C, nucleus

http://identifiers.org/biomodels.db/MODEL1310110055#_33654e86_9a66_4183_9936_6cec554e9016
initial amount: NaN
name: PIGH
is: Q14442
type: Species
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:5283
initial concentration: NaN

metaM glc D e
initial amount: NaN
is: CHEBI:4167
name: D-glucose
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: HMDB00122
type: Species
has only substance units: false

metaR r1574
fast: false
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_4cc61385_62f4_4470_acc4_cce71af490d6
is encoded by: hsa:257068
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q0VAA5
is: SBO:0000252
name: PLCXD2
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_e49a680d_0512_4ffa_b8b4_6e88675da70f
has only substance units: false
type: Species
is: B3KMA6
is: SBO:0000252
initial amount: NaN
name: ACSL3
boundary condition: true
is encoded by: hsa:2181
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_b3f9c6fc_f23a_491f_84d2_cc5db03a016f
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: NDUFA8
initial amount: NaN
constant: false
type: Species
is: B1AM93
is encoded by: hsa:4702
has only substance units: false

metaR r1788
reversible: false
product: MODEL1310110055#
modifier: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110055#
name: Y+LAT2 Utilized transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_95b3be9c_12fe_4eba_b124_56aa1614fa24
type: Species
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q96CD2
is encoded by: hsa:60490
name: PPCDC
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_9b024ca6_ef0c_4291_bd2b_ad04eb2bb373
is: P24310
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:1346
has only substance units: false
initial concentration: NaN
name: COX7A1
initial amount: NaN

metaM msa m
name: 3-oxopropanoate
is: HMDB11111
is: CHEBI:33190
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_c
is: CHEBI:15347
is: HMDB01659
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
has only substance units: false
is: SBO:0000247
constant: false
name: Type IIIA glycolipid

metaR HDD2COAtx
reversible: true
type: Reaction
name: hdd2coa intracellular transport
reactant: MODEL1310110055#
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110055#
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_03815b1c_762a_4c1c_80ea_83d97b8b4923
initial amount: NaN
name: _645740_1_c
boundary condition: true
has only substance units: false
is encoded by: hsa:645740
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false

metaM estradiol r
is: HMDB00151
name: estradiol
initial amount: NaN
boundary condition: false
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
is: CHEBI:16469
type: Species
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR r1573
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110055#
fast: false
reversible: true
product: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110055#_faf7a6cd_0a2e_4451_b5f8_d00c7c4230cc
initial concentration: NaN
initial amount: NaN
name: _AI972237_1_c
boundary condition: true
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:AI972237
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_5363355c_1a46_45b9_b484_e4d779467925
has only substance units: false
boundary condition: true
is encoded by: hsa:6901
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is: Q16635
type: Species
name: TAZ

http://identifiers.org/biomodels.db/MODEL1310110055#_04f2ce2a_a570_4c73_b5f5_ddabfc372f94
name: ALG12
type: Species
constant: false
is: Q9BV10
is encoded by: hsa:79087
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN

metaR DMHPTCRNt
fast: false
is described by: ECO:0000000
product: MODEL1310110055#
reversible: true
name: 2,6 dimethylheptanoyl crn transport
type: Reaction
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES:dmhptcoa is 'special' because its biochemical fat isn't known NJ

http://identifiers.org/biomodels.db/MODEL1310110055#_aa08ec02_28a4_46ed_8fff_4c30a4b534c8
initial concentration: NaN
is: SBO:0000252
name: NT5C1B
constant: false
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:93034
initial amount: NaN
is: Q96P26

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaM glc D g
is: CHEBI:4167
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
name: D-glucose
type: Species
is: HMDB00122
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_d3c2bc80_e409_4480_b28e_3cda2297b1b0
is: O95340
constant: false
name: PAPSS2
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:9060
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_4ff4221b_233a_49e2_887d_b561473e761c
is: O95169
has only substance units: false
name: NDUFB8
is encoded by: hsa:4714
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true

metaM fe2 c
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
constant: false
is: CHEBI:29033
is: C00023
boundary condition: false
has only substance units: false
name: Fe2+
is: HMDB00692
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM hyptaur c
initial concentration: 1.0
has only substance units: false
name: Hypotaurine
is: CHEBI:16668
initial amount: NaN
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
is: SBO:0000247
constant: false
boundary condition: false
type: Species
is: HMDB00965

metaR FUT910g
is version of: http://identifiers.org/ec-code/2.4.1.152
type: Reaction
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
product: MODEL1310110055#
name: Alpha-(1,3)-fucosyltransferase
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
is described by: ECO:0000269
fast: false
reversible: false
is: SBO:0000176
reactant: MODEL1310110055#

metaR SEBCOACROT
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

metaR ADPCOAPTE
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of adipoyl coA for release into cytosol
type: Reaction

metaM sebacid c
name: sebacicacid
is: HMDB00792
notes: FORMULA: C10H16O4 CHARGE: -2
initial amount: NaN
is: C08277
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0

metaM ficytC m
has only substance units: false
is: SBO:0000247
is: CHEBI:15991
initial concentration: 1.0
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
type: Species
boundary condition: false
constant: false
name: Ferricytochrome c
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_3d48da1a_d1de_4002_857e_5b39154890a7
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
name: AMY1C
is: SBO:0000252
is encoded by: hsa:278
is: P04745
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_e
is: CHEBI:15347
type: Species
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
name: Type IIIA glycolipid
is: HMDB01659
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_01d54466_6bd0_49e5_b603_2cf66fd93b36
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: NDUFS5
is: Q6IBA0
initial amount: NaN
boundary condition: true
is encoded by: hsa:4725

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR r0193
is: SBO:0000176
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
product: MODEL1310110055#
reversible: true
type: Reaction
reactant: MODEL1310110055#
is described by: ECO:0000000
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_313d06ea_88a0_44a7_bd1d_a05078825d90
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: SLC25A2
boundary condition: true
is: Q9BXI2
initial amount: NaN
is encoded by: hsa:83884

metaM 3dhguln c
name: 3-dehydro-L-gulonate
initial concentration: 1.0
has only substance units: false
is: CHEBI:57655
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
initial amount: NaN
type: Species
constant: false
is: HMDB06334
boundary condition: false

metaR GAPD
fast: false
product: MODEL1310110055#
name: glyceraldehyde-3-phosphate dehydrogenase
is: SBO:0000176
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.12
modifier: MODEL1310110055#
is described by: ECO:0000134

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

metaM HC01409 m
name: Hexanoyl-CoA
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
initial concentration: 1.0
boundary condition: false
is: CHEBI:27540
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR GALASE17ly
is described by: ECO:0000000
product: MODEL1310110055#
reversible: false
name: beta-galactosidase, lysosomal
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110055#

metaR r1680
name: Y+LAT2 Utilized transport
type: Reaction
reversible: false
is: SBO:0000185
product: MODEL1310110055#
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110055#

metaM acgal c
initial amount: NaN
is: SBO:0000247
is: HMDB00212
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
name: N-acetyl-D-galactosamine
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:28037

metaM dopa c
is: CHEBI:59905
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
name: dopaminium(1+)
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: HMDB00073

metaM dhcholestanate m
is: HMDB00359
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
constant: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
initial concentration: 1.0
is: CHEBI:16577

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaR r0083
product: MODEL1310110055#
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.42
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#

metaR RE3245C
is described by: ECO:0000000
fast: false
product: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
kinetic law: MODEL1310110055#
is: SBO:0000176
name: RE3245
reversible: true
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_22b45c02_2c68_4d2a_9bf6_7b37c2f7ea59
is encoded by: hsa:PRO1933
type: Species
boundary condition: true
initial amount: NaN
constant: false
name: _PRO1933_1_m
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM idp e
is: HMDB03335
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
constant: false
type: Species
is: CHEBI:58280
boundary condition: false
name: IDP(3-)
initial amount: NaN
initial concentration: 1.0

metaR ABO5g
modifier: MODEL1310110055#
reactant: MODEL1310110055#
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000269
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.37
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110055#_4bbcddff_40ce_41e8_b816_b6a01fbfaa83
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: SLC16A2
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:6567
is: P36021
constant: false

metaM dag hs e
initial amount: NaN
type: Species
name: diglyceride
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:18035
has only substance units: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0

metaM adrncrn c
is: CHEBI:16347
is: C00318
constant: false
notes: FORMULA: C29H49NO4 CHARGE: 0
type: Species
name: Adrenyl carnitine
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00062
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_g
initial concentration: 1.0
type: Species
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
initial amount: NaN
is: HMDB00304
name: Type IIIA glycolipid
constant: false
has only substance units: false
is: CHEBI:57847
is: SBO:0000247
boundary condition: false

metaM nrpphr e
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
name: Norepinephrine
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: HMDB00216
is: SBO:0000247
is: CHEBI:33569

metaM CE4792 m
has only substance units: false
initial amount: NaN
name: 3-oxo-cis-8-tetradecenoyl-CoA
constant: false
type: Species
is: CHEBI:57923
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM ttdcrn m
boundary condition: false
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3413344
name: tetradecanoyl carnitine
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
type: Species
is: HMDB05066

metaR r1570
reversible: true
reactant: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110055#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_cb1582c2_85c1_40c8_b863_a5db647de59e
constant: false
is: Q53YE7
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
name: MAOA
is encoded by: hsa:4128
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_5be1eb6c_5384_4f81_8407_49953db9cfbb
type: Species
boundary condition: true
has only substance units: false
constant: false
name: ACAA1
is: SBO:0000252
initial concentration: NaN
is: Q96CA6
initial amount: NaN
is encoded by: hsa:30

metaR r0191
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000176
reversible: false
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.24
fast: false
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
modifier: MODEL1310110055#

metaR r0084
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.1.1.42
product: MODEL1310110055#
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_3052a47b_54ed_4f54_b658_2164599963f0
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q53HM1
has only substance units: false
is encoded by: hsa:54963
initial amount: NaN
boundary condition: true
name: UCKL1

http://identifiers.org/biomodels.db/MODEL1310110055#_a84c52ec_6eae_4736_910f_23f927df8963
is encoded by: hsa:91734
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is: Q9BXS1
initial amount: NaN
has only substance units: false
name: IDI2

http://identifiers.org/biomodels.db/MODEL1310110055#_905d553c_9700_4a65_8226_c59a61e5791b
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:NM 013421
name: _NM_013421_1_m

http://identifiers.org/biomodels.db/MODEL1310110055#_2ef76d67_4ac3_461c_8985_cb69da05a665
is: SBO:0000252
boundary condition: true
is: A8K4A0
initial amount: NaN
constant: false
name: ARSB
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:411

metaR HOCTDECCRNe
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyoctadecanoyl carnitine into extra cellular space
type: Reaction

metaM 3pg c
initial concentration: 1.0
type: Species
boundary condition: false
is: C00197
constant: false
name: 3-Phospho-D-glycerate
has only substance units: false
is: HMDB00807
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3497
is: CHEBI:58272
is: SBO:0000247

metaM estradiol e
is: SBO:0000247
boundary condition: false
is: HMDB00151
initial concentration: 1.0
name: estradiol
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
is: CHEBI:16469
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaM mlthf c
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:15636
boundary condition: false
is: SBO:0000247
is: HMDB01533
has only substance units: false
type: Species
is: C00143
name: 5,10-Methylenetetrahydrofolate

metaR r1682
fast: false
modifier: MODEL1310110055#
reversible: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110055#_5f52928d_0ca9_4ed7_93b9_83a118ae25c4
constant: false
is: SBO:0000252
is: A8K5J1
has only substance units: false
is encoded by: hsa:7372
type: Species
initial amount: NaN
name: UMPS
initial concentration: NaN
boundary condition: true

metaR r0085
kinetic law: MODEL1310110055#
product: MODEL1310110055#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42
modifier: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
reversible: false
is: SBO:0000176
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3

metaM nrpphr c
is: CHEBI:33569
name: Norepinephrine
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
initial amount: NaN
boundary condition: false
is: HMDB00216
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species

metaR ECOAH12m
is described by: ECO:0000304
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
type: Reaction
product: MODEL1310110055#

metaM dmhptcrn m
boundary condition: false
is: HMDB06320
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
name: 2,6 dimethylheptanoyl carnitine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_cd3eac56_a1bf_46a4_978d_43d28ba6fb78
is encoded by: hsa:23236
constant: false
initial amount: NaN
type: Species
is: Q9NQ66
has only substance units: false
boundary condition: true
is: SBO:0000252
name: PLCB1
initial concentration: NaN

metaR OIVD2m
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.8.1.4
type: Reaction
is described by: ECO:0000269
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.4
name: 2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxobutanoate), mitochondrial
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
product: MODEL1310110055#
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.3.1.168
fast: false
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_9fef0f8f_7b67_4d27_a26f_c45acce3925e
is: P11166
is: SBO:0000252
is encoded by: hsa:6513
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
name: SLC2A1

http://identifiers.org/biomodels.db/MODEL1310110055#_c16fe3b1_abf9_4d15_87cd_2694058f1cf5
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: PYCR1
boundary condition: true
is encoded by: hsa:5831
type: Species
is: A6NFM2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_56c12090_5bff_4dfe_a107_5c398f9580f3
is encoded by: hsa:5295
initial concentration: NaN
name: PIK3CB:PIK3R1
has part: B3KT19
has only substance units: false
boundary condition: true
is encoded by: hsa:5291
has part: B4DER4
type: Species
constant: false
is: SBO:0000297
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_4817ade5_a4a6_4cea_a4e0_b643741719de
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
name: PC
initial concentration: NaN
is encoded by: hsa:5091
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_e01a93fa_66ff_44fd_931f_273ad35e6c6e
is encoded by: hsa:7001
boundary condition: true
is: SBO:0000252
type: Species
name: PRDX2
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM utp n
has only substance units: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: SBO:0000247
is: CHEBI:46398
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00285
initial concentration: 1.0
name: UTP(4-)

metaM mn l
has only substance units: false
initial amount: NaN
boundary condition: false
name: beta-1,4-mannose-N-acetylglucosamine
initial concentration: 1.0
type: Species
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
is: HMDB06535
constant: false
is: SBO:0000247

metaM C02528 c
initial concentration: 1.0
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
constant: false
type: Species
has only substance units: false
is: SBO:0000247
name: chenodeoxycholate
initial amount: NaN
is: CHEBI:36234
boundary condition: false
is: HMDB00518

metaR OMHPALTD
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_65fd9824_9062_4021_b57d_b6cf649feca4
has only substance units: false
is: SBO:0000252
is encoded by: hsa:56895
type: Species
initial amount: NaN
name: AGPAT4
initial concentration: NaN
boundary condition: true
constant: false
is: Q9NRZ5

http://identifiers.org/biomodels.db/MODEL1310110055#_f38be309_4d82_4472_b48b_14f9ac0420bf
is encoded by: hsa:6647
constant: false
is: P00441
initial amount: NaN
initial concentration: NaN
name: SOD1
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species

metaR HIStiDF
type: Reaction
notes: GENE_ASSOCIATION: (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES:SAB
reversible: false
fast: false
name: L-histidine transport via diffusion (extracellular to cytosol)
modifier: MODEL1310110055#
is described by: ECO:0000269
product: MODEL1310110055#
is: SBO:0000185
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#

metaM 2oxoadp m
initial amount: NaN
constant: false
is: HMDB00225
name: 2-oxoadipate(2-)
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57499
type: Species
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: SBO:0000247

metaR HISTAtu
is described by: ECO:0000269
reactant: MODEL1310110055#
type: Reaction
reversible: true
modifier: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
name: Histamine uniport
fast: false
kinetic law: MODEL1310110055#
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_513dc3fd_04b5_4202_b268_6479fc11b2e8
name: NDUFA5
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:4698
is: SBO:0000252
is: Q16718

metaM fe2 m
is: HMDB00692
boundary condition: false
type: Species
constant: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: C00023
is: SBO:0000247
initial amount: NaN
name: Fe2+
is: CHEBI:29033
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_80b2d524_1b34_431d_b896_62fcda78062c
is encoded by: hsa:10999
is: Q6P1M0
type: Species
initial amount: NaN
name: SLC27A4
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_a91b7924_a791_4196_96a9_2a06c52c1093
name: PIGX:PIGM
type: Species
is encoded by: hsa:93183
is encoded by: hsa:54965
has part: Q8TBF5
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000297
has only substance units: false
has part: Q9H3S5

metaM acgal g
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
is: SBO:0000247
is: HMDB00212
has only substance units: false
name: N-acetyl-D-galactosamine
constant: false
initial amount: NaN
is: CHEBI:28037
initial concentration: 1.0
type: Species

metaR DTDPtn
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: dTDP nuclear transport
is described by: ECO:0000000
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_a914fdff_d521_488e_a04d_218ba66137da
boundary condition: true
constant: false
initial concentration: NaN
name: LDHAL6B
is: SBO:0000252
is: Q9BYZ2
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:92483

http://identifiers.org/biomodels.db/MODEL1310110055#_2c791226_046c_4e4b_9be7_48822985b0dd
is: Q11201
type: Species
boundary condition: true
initial amount: NaN
constant: false
name: ST3GAL1
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6482
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_ab155c44_2b5b_49dd_926a_5b3c4a35bf98
name: TK2
is encoded by: hsa:7084
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: O00142

metaR r0614
reactant: MODEL1310110055#
type: Reaction
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
kinetic law: MODEL1310110055#
fast: false
reversible: true
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110055#_d673f0fe_013a_4a85_b889_cfa3fb0cb70e
is: Q8TF71
name: SLC16A10
is encoded by: hsa:117247
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM nadp x
initial amount: NaN
is: CHEBI:58349
is: C00006
is: HMDB00217
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_e45ca6ad_e36a_434c_abe9_cac46499688d
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
name: _7359_1_c
is encoded by: hsa:7359
initial amount: NaN
initial concentration: NaN
constant: false

metaM hs l
is: CHEBI:28815
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: heparan sulfate, free chain
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C79H114N5O102S12 CHARGE: -13

http://identifiers.org/biomodels.db/MODEL1310110055#_3b55caa5_01f3_457e_832a_c3d52a07e0a9
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:5210
name: PFKFB4
is: Q16877
is: SBO:0000252
initial amount: NaN

metaM cholcoa c
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
is: CHEBI:57373
is: HMDB01374
is: SBO:0000247
name: choloyl-CoA(4-)
initial amount: NaN

metaR NADPHtxu
kinetic law: MODEL1310110055#
reversible: false
reactant: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ free hydrogens NJ
is: SBO:0000185
fast: false
product: MODEL1310110055#
is described by: ECO:0000000
name: NADPH transporter, peroxisome

metaR RE1527M
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
product: MODEL1310110055#
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1527
reversible: true
reactant: MODEL1310110055#
type: Reaction

metaR r0615
modifier: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reversible: true
is: SBO:0000176
reactant: MODEL1310110055#
is described by: ECO:0000000
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is version of: http://identifiers.org/ec-code/2.3.1.168
kinetic law: MODEL1310110055#
fast: false
type: Reaction

metaR r2508
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110055#
reversible: true
is: SBO:0000185
product: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
name: Utilized transport
type: Reaction

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_d7354164_fbab_4899_b4af_7aafe8ae8866
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: SLC7A8
is: SBO:0000252
is encoded by: hsa:23428
is: Q86U05
type: Species

metaR C12DCACOT
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of dodecanedioyl coa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_2d6f4428_c6c2_4312_830a_8c24e985f07e
initial amount: NaN
constant: false
is: Q9C0J1
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
name: B3GNT4
is encoded by: hsa:79369

metaM dopa e
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: HMDB00073
name: dopaminium(1+)
is: CHEBI:59905

metaR r0081
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
is version of: http://identifiers.org/ec-code/1.5.1.12
type: Reaction
reactant: MODEL1310110055#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_98e63cef_33a7_4d76_8187_cf94fecb4b59
name: DGAT1
is encoded by: hsa:8694
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: O75907
is: SBO:0000252
boundary condition: true

metaM ksi pre24 g
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
is: HMDB00175
initial concentration: 1.0
type: Species
is: SBO:0000247
is: C00130
constant: false
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 24
has only substance units: false
boundary condition: false
initial amount: NaN

metaM arg L m
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00517
name: L-argininium(1+)
type: Species
is: CHEBI:32682
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial concentration: 1.0
constant: false

metaM 4aphdob c
is: HMDB00978
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
constant: false
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:58147
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_81ebcde8_562e_4841_808c_de554641c074
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
name: EGFR
constant: false
is encoded by: hsa:1956
initial amount: NaN
is: P00533

metaM urate e
initial concentration: 1.0
type: Species
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
initial amount: NaN
is: C00366
name: Urate
has only substance units: false
is: SBO:0000247
is: HMDB00289
constant: false
is: CHEBI:17775
boundary condition: false

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_b06ded6b_ddaa_4b85_9c6e_966661ef7795
boundary condition: true
name: MVD
initial amount: NaN
is: P53602
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4597
constant: false
is: SBO:0000252

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaR r1666
reactant: MODEL1310110055#
name: Y+LAT2 Utilized transport
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reversible: true
is: SBO:0000185
product: MODEL1310110055#

metaM gmp e
initial amount: NaN
name: GMP(3-)
is: HMDB01397
constant: false
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:58115
initial concentration: 1.0
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
has only substance units: false

metaR S23T3g
modifier: MODEL1310110055#
reactant: MODEL1310110055#
reversible: false
fast: false
product: MODEL1310110055#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110055#
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
is version of: http://identifiers.org/ec-code/2.4.99.6
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110055#_fb3d30be_40b6_4030_bab3_97a5ce69578c
initial amount: NaN
is encoded by: hsa:3295
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: E9PB82
type: Species
name: HSD17B4
is: SBO:0000252

metaM c6dc x
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C13H22NO6 CHARGE: -1
is: C14143
boundary condition: false
name: adipoyl carnitine
constant: false
initial concentration: 1.0
is: HMDB04047
type: Species
has only substance units: false

metaM prostge2 c
is: CHEBI:606564
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
type: Species
is: HMDB01220
is: SBO:0000247
name: prostaglandin E2(1-)
boundary condition: false

metaR NH4tn
kinetic law: MODEL1310110055#
reversible: true
reactant: MODEL1310110055#
type: Reaction
product: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
fast: false
name: ammonia nuclear transport
is described by: ECO:0000000

metaR NDPK1
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:GDP)
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
modifier: MODEL1310110055#

metaM HC00319 c
initial amount: NaN
is: CHEBI:30794
has only substance units: false
name: Malonate
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)

metaM cbasp e
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:32814
is: C00438
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00828
name: N-Carbamoyl-L-aspartate
notes: FORMULA: C5H6N2O5 CHARGE: -2

metaR B3GNT310g
is described by: ECO:0000254
type: Reaction
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
kinetic law: MODEL1310110055#
is: SBO:0000176
product: MODEL1310110055#
reversible: false
reactant: MODEL1310110055#
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
fast: false

metaM 5mdru1p c
is: CHEBI:58548
constant: false
initial concentration: 1.0
is: HMDB01299
type: Species
has only substance units: false
name: 5-Methylthio-5-deoxy-D-ribulose 1-phosphate
is: SBO:0000247
boundary condition: false
is: C04582
initial amount: NaN
notes: FORMULA: C6H11O7PS CHARGE: -2

metaR PMANM
product: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
name: phosphomannomutase
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/5.4.2.2
is version of: http://identifiers.org/ec-code/5.4.2.8
is described by: ECO:0000000
kinetic law: MODEL1310110055#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
reversible: true

metaM cytd c
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
type: Species
has only substance units: false
name: Cytidine
is: CHEBI:17562
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: C00475
is: HMDB00089

http://identifiers.org/biomodels.db/MODEL1310110055#_0a89a2ca_b86d_4be3_a769_198fac6280cb
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:522
initial concentration: NaN
name: ATP5J
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_c873f1ea_febf_4c5a_bfd5_a0e0db7ff3f5
constant: false
is encoded by: hsa:5315
initial concentration: NaN
is: B4DNK4
name: PKM2
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false

metaM glc D r
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:4167
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: SBO:0000247
is: HMDB00122
constant: false
has only substance units: false
name: D-glucose
type: Species

metaR r1667
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110055#
reactant: MODEL1310110055#
modifier: MODEL1310110055#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110055#
type: Reaction

metaM 12ppd R c
name: (R)-propane-1,2-diol
initial amount: NaN
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01881
is: CHEBI:28972
type: Species

metaM CE4872 c
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:15748
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
is: HMDB00127

metaM cdpdag hs m
type: Species
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
is: SBO:0000247
name: CDP-diacylglycerol(2-)
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:58332
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_d55f6c14_2bab_4483_86f5_95c474087877
initial amount: NaN
name: CRAT
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:1384
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM mlthf m
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
name: 5,10-Methylenetetrahydrofolate
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:15636
has only substance units: false
constant: false
is: HMDB01533
is: C00143

metaM CE2839 e
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
type: Species
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
constant: false
name: maltodecaose
boundary condition: false
is: C01936
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR r1664
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
is described by: ECO:0000000
reversible: true
product: MODEL1310110055#
is: SBO:0000185

metaM gmp c
initial amount: NaN
is: HMDB01397
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
boundary condition: false
type: Species
constant: false
name: GMP
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58115
is: C00144
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_b6fd3dc8_5fad_4cab_a775_1a9bee1fade2
name: GALNT13
has only substance units: false
is: Q8IUC8
constant: false
is encoded by: hsa:114805
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN

metaM urate c
is: CHEBI:17775
name: Urate
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00289
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
has only substance units: false
is: C00366

http://identifiers.org/biomodels.db/MODEL1310110055#_656a578a_389b_4838_a89e_dc41a01c205c
initial concentration: NaN
is encoded by: hsa:1327
is encoded by: hsa:9167
is encoded by: hsa:4514
constant: false
has part: P09669
has part: Q53XN1
initial amount: NaN
is encoded by: hsa:170712
has part: Q02221
has part: Q7GXY8
has part: P14854
has part: P20674
has part: Q7Z4L0
has part: P15954
has part: Q53YB7
is encoded by: hsa:1345
has only substance units: false
is encoded by: hsa:1340
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: P13073
has part: P00414
is encoded by: hsa:1350
is: SBO:0000297
is encoded by: hsa:1347
is encoded by: hsa:125965
has part: P12074
is encoded by: hsa:1339
has part: Q6FGA0
is encoded by: hsa:1337
is encoded by: hsa:1329
is encoded by: hsa:1346
has part: P24310
is encoded by: hsa:9377
has part: P24311
has part: Q96KJ9
is encoded by: hsa:1351
is encoded by: hsa:341947
is encoded by: hsa:4513
is encoded by: hsa:84701
has part: Q7GXZ8
boundary condition: true
has part: H0UI06
is encoded by: hsa:4512
has part: Q6YFQ2
type: Species
has part: Q8TF08
is encoded by: hsa:1349

metaM so3 m
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
constant: false
is: HMDB00240
name: hydrogensulfite
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:17137

metaM acgbgbside hs l
constant: false
is: CHEBI:17411
has only substance units: false
name: beta GalNAc globoside
initial concentration: 1.0
is: HMDB00215
is: SBO:0000247
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_e6e6a7a2_1833_487d_a755_043a690ed1e4
has only substance units: false
type: Species
initial concentration: NaN
is: B3KUK6
boundary condition: true
name: NT5C1B
constant: false
is encoded by: hsa:93034
is: SBO:0000252
initial amount: NaN

metaR CSAPASEly
product: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)
reversible: false
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110055#
is: SBO:0000176

metaM 3octdectecoa x
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/5280355
type: Species
is: SBO:0000247
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial amount: NaN
name: 3,6,9,12-octadecatetraenoylcoa
constant: false
has only substance units: false

metaR SPHS1Ptr
type: Reaction
reversible: true
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
name: sphingosine-1-phosphate transport
reactant: MODEL1310110055#

metaM C05280 m
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
initial concentration: 1.0
is: HMDB03952
name: cis,cis-3,6-Dodecadienoyl-CoA
is: SBO:0000247
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:28002

http://identifiers.org/biomodels.db/MODEL1310110055#_160e4b40_a3c7_43fa_b979_a8b565d455c2
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:10905
initial concentration: NaN
is: O60476
name: MAN1A2

metaM f6p c
initial amount: NaN
constant: false
initial concentration: 1.0
name: D-Fructose 6-phosphate
is: C00085
is: SBO:0000247
is: HMDB00124
is: CHEBI:57579
has only substance units: false
is: http://identifiers.org/pubchem.compound/3385
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_b1b53532_9fee_41af_ba8d_deb3fab342bc
initial concentration: NaN
is: A4D1N9
has only substance units: false
is encoded by: hsa:669
constant: false
name: BPGM
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_ff21f776_79fe_431b_aab8_ceab8ccadd83
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: A8K9Q8
name: B3GNT6
is encoded by: hsa:192134
has only substance units: false

metaR THMMPt4
is: SBO:0000185
kinetic law: MODEL1310110055#
name: Thiamine monophosphate transport in via anion antiport
modifier: MODEL1310110055#
reversible: true
fast: false
type: Reaction
product: MODEL1310110055#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6573.1) or (6573.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10542220,PMID:14770311 NOTES:IT
reactant: MODEL1310110055#

metaM HC02214 c
initial amount: NaN
is: CHEBI:28852
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
has only substance units: false
constant: false
name: prostaglandin-f1alpha
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_aa1d7f7d_b949_4050_bac1_e447905d7194
is encoded by: hsa:1962
has part: O15254
initial amount: NaN
is encoded by: hsa:8310
type: Species
is: SBO:0000297
name: EHHADH:ACAA1:HSD17B4:ACOX3
has part: Q9NY65
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false

metaR r1665
type: Reaction
modifier: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
name: Y+LAT2 Utilized transport

metaM ksi pre21 g
has only substance units: false
is: HMDB00175
is: CHEBI:58053
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
name: keratan sulfate I biosynthesis, precursor 21
is: C00130
initial amount: NaN
is: SBO:0000247

metaR RAI2
kinetic law: MODEL1310110055#
type: Reaction
reversible: true
name: retinal isomerase (9-cis)
is: SBO:0000176
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
reactant: MODEL1310110055#
is described by: ECO:0000000

metaR HISD
reactant: MODEL1310110055#
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/4.3.1.3
reversible: false
name: histidase
is described by: ECO:0000269
kinetic law: MODEL1310110055#
is: SBO:0000176
modifier: MODEL1310110055#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110055#_4e5448d9_8b48_485f_af53_702072625cf9
constant: false
type: Species
is encoded by: hsa:8789
has only substance units: false
is: O00757
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: FBP2

metaR NDPK6
is: SBO:0000176
name: Nucleoside-diphosphate kinase (ATP:dUDP)
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110055#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_85cea7fa_0365_4227_8396_be6dd429b325
name: GALNT5
is: A5PKZ1
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:11227

metaR NDPK5
is: SBO:0000176
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#
is described by: ECO:0000269
reversible: true
name: Nucleoside-diphosphate kinase (ATP:dGDP)
fast: false

metaM dhap x
initial concentration: 1.0
is: HMDB01473
name: Dihydroxyacetone phosphate
is: CHEBI:57642
has only substance units: false
initial amount: NaN
is: C00111
is: http://identifiers.org/pubchem.compound/3411
constant: false
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_9db5b73d_a615_44d6_ba2d_0977c89ae407
boundary condition: true
is encoded by: hsa:6534
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q99884
name: SLC6A7

http://identifiers.org/biomodels.db/MODEL1310110055#_f840c21a_83eb_4391_8ad7_dfd5dcdbabae
is encoded by: hsa:5634
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
name: PRPS2
initial concentration: NaN
is: P11908
type: Species

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

metaM fad m
is: SBO:0000247
constant: false
name: Flavin adenine dinucleotide oxidized
initial concentration: 1.0
has only substance units: false
is: HMDB01248
type: Species
is: CHEBI:16238
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: C00016

http://identifiers.org/biomodels.db/MODEL1310110055#_93762c50_5bd9_4ba6_a684_9ac4bf67bc51
is: SBO:0000252
name: PIP4K2C
type: Species
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:79837
boundary condition: true
is: B3KQV3
initial concentration: NaN

metaM hdd2coa m
is: CHEBI:61526
name: trans-Hexadec-2-enoyl-CoA
type: Species
constant: false
is: C05272
initial concentration: 1.0
is: HMDB03945
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false

metaM ppi e
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:33019
name: Diphosphate
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: C00013
constant: false

metaR NODe
product: MODEL1310110055#
is described by: ECO:0000134
reactant: MODEL1310110055#
is: SBO:0000185
kinetic law: MODEL1310110055#
name: NODe
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reversible: true

metaM eitetcoa x
has only substance units: false
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: 5,8,11,14-eicosatetraenoylcoa
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790

metaR NDPK4
name: nucleoside-diphosphate kinase (ATP:dTDP)
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110055#
type: Reaction
fast: false
product: MODEL1310110055#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM damp c
is: SBO:0000247
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
is: CHEBI:58245
has only substance units: false
is: HMDB00905
initial concentration: 1.0
constant: false
boundary condition: false
name: dAMP(2-)
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_7e3d200a_5c04_42b2_a7e1_7c35f1eaccda
is: P54802
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4669
name: NAGLU
type: Species
constant: false
initial concentration: NaN

metaR FBP26
name: Fructose-2,6-bisphosphate 2-phosphatase
kinetic law: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.105
is version of: http://identifiers.org/ec-code/3.1.3.11
fast: false
product: MODEL1310110055#
modifier: MODEL1310110055#
reversible: false
is: SBO:0000176
reactant: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2203.1) or (5210.1) or (5207.1) or (5209.1) or (5208.1) or (8789.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 3.1.3.46 Confidence Level: 0 AUTHORS: NOTES:IF

metaR r0186
type: Reaction
fast: false
product: MODEL1310110055#
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaM lnlc e
name: linoleate
boundary condition: false
type: Species
is: CHEBI:30245
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00673

metaM acgbgbside hs g
is: SBO:0000247
initial amount: NaN
is: HMDB00215
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:17411
name: beta GalNAc globoside
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
constant: false
has only substance units: false

metaM L2aadp6sa m
is: HMDB01263
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17917
name: L-allysine
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR FAOXC12DCx
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanedioyl carnitine
type: Reaction

metaM 20ahchsterol m
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: HMDB06283
is: CHEBI:1296
name: 20-hydroxycholesterol
boundary condition: false
type: Species

metaM gmp g
is: HMDB01397
boundary condition: false
name: GMP(3-)
is: CHEBI:58115
has only substance units: false
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
initial concentration: 1.0

metaR NDPK3
fast: false
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110055#
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:CDP)

metaR RE3624M
is: SBO:0000176
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE3624
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#

metaR r1668
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
modifier: MODEL1310110055#
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_294adad3_4c6d_4abf_acca_8f895db984b9
initial concentration: NaN
name: ACOX3
is: O15254
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:8310
has only substance units: false
is: SBO:0000252
constant: false

metaM 4abut n
is: SBO:0000247
is: HMDB00112
type: Species
is: C00334
notes: FORMULA: C4H9NO2 CHARGE: 0
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
name: 4-Aminobutanoate

metaM retinal cis 9 c
has only substance units: false
is: HMDB01358
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: all-trans-retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
type: Species
is: CHEBI:17898
constant: false

metaM cytd e
name: Cytidine
is: HMDB00089
type: Species
is: CHEBI:17562
initial amount: NaN
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: C00475
constant: false

metaR DADNt4
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
reversible: true
name: deoxyadenosine transport via diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reactant: MODEL1310110055#

metaM biocyt e
is: HMDB03134
name: Biocytin
is: C05552
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7886

metaR FATP9t
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.7
product: MODEL1310110055#
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
name: fatty acid electroneutral transport
is: SBO:0000185
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/6.2.1.3

metaM ppi c
has only substance units: false
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3
name: Diphosphate
boundary condition: false
initial concentration: 1.0
is: HMDB00250
constant: false
is: CHEBI:0
initial amount: NaN
type: Species
is: C00013

metaR r0074
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
type: Reaction
fast: false
product: MODEL1310110055#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110055#
modifier: MODEL1310110055#
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.1
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_e7a4fca7_4d24_4e0f_85e3_458355f460dd
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q8TB61
type: Species
initial amount: NaN
name: SLC35B2
boundary condition: true
is encoded by: hsa:347734
constant: false

metaM cbasp c
type: Species
has only substance units: false
is: C00438
is: CHEBI:32814
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00828
boundary condition: false
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
initial concentration: 1.0
name: N-Carbamoyl-L-aspartate

metaR RTOTAL2FATPc
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

metaR DUDPtn
type: Reaction
reactant: MODEL1310110055#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110055#
name: dUDP nuclear transport
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false

metaR NDPK2
reactant: MODEL1310110055#
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:UDP)
fast: false
product: MODEL1310110055#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_7e7e7a25_496a_4b23_a5e7_e379bcf1b385
boundary condition: true
is: SBO:0000252
name: DGUOK
initial amount: NaN
initial concentration: NaN
is: E5KSL6
is encoded by: hsa:1716
has only substance units: false
constant: false
type: Species

metaR ADSS
fast: false
reactant: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.4
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110055#
is: SBO:0000176
name: adenylosuccinate synthase
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
product: MODEL1310110055#

metaR r1669
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110055#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
is: SBO:0000185

metaM 4abut m
is: C00334
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
initial concentration: 1.0
type: Species
is: CHEBI:16865
name: 4-Aminobutanoate
initial amount: NaN
is: HMDB00112

http://identifiers.org/biomodels.db/MODEL1310110055#_87d0d29c_62f3_4d25_b464_7c9fce033a3f
initial concentration: NaN
is: SBO:0000252
name: ATP5J
type: Species
is encoded by: hsa:522
constant: false
is: P18859
initial amount: NaN
has only substance units: false
boundary condition: true

metaR PAPStg
name: 3'-Phosphoadenylyl sufate Golgi transport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
modifier: MODEL1310110055#
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
product: MODEL1310110055#

metaR DM fol
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_42a7df8b_0831_4f67_bd74_5b229dc9f06a
has only substance units: false
is: P30520
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: ADSS
type: Species
constant: false
is encoded by: hsa:159
initial amount: NaN

metaM so3 c
initial concentration: 1.0
is: C00094
boundary condition: false
is: CHEBI:17137
is: SBO:0000247
name: Sulfite
constant: false
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: HMDB00240
has only substance units: false
type: Species
initial amount: NaN

metaR FAOXC18C18OHm
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18-->C18OH)m
type: Reaction

metaR DCSPTN1t
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110055#
is: SBO:0000185
name: fatty acid transport via diffusion
kinetic law: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110055#

metaM HC00319 m
constant: false
has only substance units: false
name: Malonate
is: CHEBI:30794
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial amount: NaN
type: Species

metaR FOLt2le
name: folate transport via anion exchange
is described by: ECO:0000134
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reversible: true
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_4483069e_acc6_40ad_b4e0_a4d23cd4c5d9
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is: E9PDD5
name: IDH3G
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3421

http://identifiers.org/biomodels.db/MODEL1310110055#_f41381b6_2576_40ff_a1ab_618974e5dbd8
is encoded by: hsa:109
initial amount: NaN
type: Species
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is: B3KT86
name: ADCY3
initial concentration: NaN

metaR DPCOAK
type: Reaction
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.7.3
reversible: false
modifier: MODEL1310110055#
is described by: ECO:0000269
kinetic law: MODEL1310110055#
name: dephospho-CoA kinase
is: SBO:0000176
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
product: MODEL1310110055#

metaR RDH1a
kinetic law: MODEL1310110055#
fast: false
is: SBO:0000176
product: MODEL1310110055#
name: retinol dehydrogenase (all-trans,NADPH)
is version of: http://identifiers.org/ec-code/1.1.1.105
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.300
reactant: MODEL1310110055#
reversible: true

metaR q10h2tc
product: MODEL1310110055#
is: SBO:0000185
name: transport of ubiquinol into cytosol
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110055#
type: Reaction
is described by: ECO:0000134
fast: false
reactant: MODEL1310110055#

metaR PHACCOAGLNAC
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110055#
reversible: false
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110055#
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
is described by: ECO:0000000

metaR HSD17B42x
product: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
fast: false
name: hydroxysteroid (17-beta) dehydrogenase 4
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
reversible: false
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/4.2.1.107

http://identifiers.org/biomodels.db/MODEL1310110055#_56a1fe6e_af05_43af_957b_f323913287b7
is: Q11203
type: Species
is: SBO:0000252
is encoded by: hsa:6487
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: ST3GAL3
boundary condition: true

metaM CE5854 e
is: HMDB02710
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
initial amount: NaN
name: gama-CEHC-glucuronide
has only substance units: false
constant: false
type: Species
is: SBO:0000247
is: CHEBI:27485
initial concentration: 1.0
boundary condition: false

metaR FACOAL140i
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
reactant: MODEL1310110055#
reversible: false
modifier: MODEL1310110055#
is described by: ECO:0000269
product: MODEL1310110055#
name: fatty-acid--CoA ligase (tetradecanoate)
type: Reaction
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
is: SBO:0000176

metaR 4NPHSULT
fast: false
is: SBO:0000176
reactant: MODEL1310110055#
is described by: ECO:0000269
product: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
name: 4-Nitrophenol Sulfotransferase
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.1

metaR FADH2tx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
kinetic law: MODEL1310110055#
is: SBO:0000185
name: FADH2 transporter, peroxisomal
product: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000

metaM man l
boundary condition: false
constant: false
type: Species
is: HMDB00169
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16024
name: D-mannose
has only substance units: false

metaM arachcoa e
initial amount: NaN
type: Species
is: HMDB04258
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:15527
name: arachidyl coenzyme A
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
boundary condition: false
has only substance units: false

metaR DOPASFt
kinetic law: MODEL1310110055#
type: Reaction
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: false
name: Dopamine 3-0-sulfate transport (diffusion)
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_c6d2498a_a337_4e06_b14b_bcd955385cbd
has only substance units: false
name: ALDH5A1
is: SBO:0000252
is: Q546H9
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:7915
initial amount: NaN
boundary condition: true

metaR NDPK9
kinetic law: MODEL1310110055#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110055#
reversible: true
reactant: MODEL1310110055#
type: Reaction
name: nucleoside-diphosphate kinase (ATP:IDP)
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
modifier: MODEL1310110055#
fast: false
is: SBO:0000176

metaM cholcoa x
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: HMDB01374
initial concentration: 1.0
name: choloyl-CoA(4-)
is: CHEBI:57373
boundary condition: false

metaM HC00361 c
initial amount: NaN
is: SBO:0000247
name: sedoheptulose 1,7-bisphosphate(4-)
type: Species
is: CHEBI:58335
constant: false
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR r1559
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
product: MODEL1310110055#

metaM uppg3 c
type: Species
has only substance units: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00643 EHMN_ABBREVIATION: C01051
is: C01051
is: SBO:0000247
is: CHEBI:57308
initial concentration: 1.0
name: Uroporphyrinogen III
initial amount: NaN
is: HMDB01086
boundary condition: false
constant: false

metaM ocdca c
is: CHEBI:25629
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: stearate
type: Species
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
is: HMDB00827
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_fb5d60db_366c_4fb9_b040_e9833644d28f
is: P04183
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
name: TK1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7083
constant: false

metaM dudp c
name: dUDP
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: CHEBI:60471
initial amount: NaN
is: HMDB01000
boundary condition: false
constant: false
has only substance units: false
is: C01346
is: SBO:0000247
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_810057cf_05cc_4257_a7a4_d0c49f3ffcd0
constant: false
type: Species
has only substance units: false
name: ST3GAL3
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6487
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_333dbd33_e108_416d_9b3e_036fc4e65a40
initial amount: NaN
boundary condition: true
name: ACP1
has only substance units: false
constant: false
is: P24666
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:52
type: Species

metaR PCHOLP hs
name: choline phosphatase
is: SBO:0000176
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.4
type: Reaction
modifier: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ

metaR NDPK8
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
product: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
name: Nucleoside-diphosphate kinase (ATP:dADP)
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
type: Reaction
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_446ed3ba_375a_4b87_9430_361cb73cc2db
constant: false
is: Q53HE2
initial amount: NaN
is encoded by: hsa:7167
initial concentration: NaN
name: TPI1
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaM HC01408 m
has only substance units: false
is: SBO:0000247
name: 3-Oxohexanoyl-CoA
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
is: CHEBI:27648

http://identifiers.org/biomodels.db/MODEL1310110055#_ba3d19e3_0043_45a8_a964_f37eb54374ab
name: ATP5F1
is: P24539
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:515
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true

metaM oaa m
type: Species
has only substance units: false
initial concentration: 1.0
name: Oxaloacetate
is: CHEBI:16452
is: SBO:0000247
boundary condition: false
is: HMDB00223
initial amount: NaN
constant: false
is: C00036
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036

metaR r1781
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110055#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
modifier: MODEL1310110055#
reversible: false
fast: false
is: SBO:0000185
product: MODEL1310110055#

metaR RE1517M
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
product: MODEL1310110055#
type: Reaction
name: RE1517
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.3.99.13
is: SBO:0000176
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
modifier: MODEL1310110055#
is described by: ECO:0000000

metaR UDPGLCter
type: Reaction
fast: false
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
reversible: true
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000000
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_342d1fbe_44c8_4f29_ba6d_9e0204295a07
initial concentration: NaN
is: Q96RV2
constant: false
is encoded by: hsa:3038
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
name: HAS3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_49752114_1e56_4fa5_80fd_4bdae901d052
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8525
is: SBO:0000252
has only substance units: false
constant: false
is: B7Z2M9
name: DGKZ
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_b44c9f9e_5563_4860_be8a_579b062794d8
is: P30084
is encoded by: hsa:1892
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: ECHS1
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaR r1459
fast: false
is: SBO:0000185
reactant: MODEL1310110055#
name: Transport reaction
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110055#

metaM xol7ah3 m
is: HMDB12455
type: Species
boundary condition: false
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha,26-triol
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:28540
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_a2304305_4ebd_4d1d_9c68_576abc71fb8d
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: AMPD2
is encoded by: hsa:271
is: Q01433

metaR NDPK7
kinetic law: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110055#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110055#
name: nucleoside-diphosphate kinase (ATP:dCDP)
reactant: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false

metaR DNDPt34m
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dGDP transport via dTDP antiport
is: SBO:0000185
kinetic law: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
reversible: false

metaR TDCHOLAte
is described by: ECO:0000000
name: bile acid intracellular transport
product: MODEL1310110055#
type: Reaction
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaR G14T12g
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90

metaM fad x
has only substance units: false
constant: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
name: Flavin adenine dinucleotide oxidized
is: HMDB01248
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:16238
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_1a9cf581_ece0_4856_9482_051eb8aaa3a6
constant: false
boundary condition: true
initial amount: NaN
type: Species
name: ACOT2
is encoded by: hsa:10965
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P49753

metaR HSAT3ly
is described by: ECO:0000000
product: MODEL1310110055#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
fast: false
reactant: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
type: Reaction

metaM L2aadp6sa c
constant: false
is: CHEBI:17917
initial concentration: 1.0
is: HMDB01263
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
initial amount: NaN
boundary condition: false
type: Species
name: L-allysine
is: SBO:0000247
has only substance units: false

metaM gsn c
type: Species
is: CHEBI:16750
is: C00387
is: SBO:0000247
has only substance units: false
boundary condition: false
name: Guanosine
is: HMDB00133
initial concentration: 1.0
constant: false
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
initial amount: NaN

metaM CE4872 m
initial amount: NaN
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00127
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:15748

http://identifiers.org/biomodels.db/MODEL1310110055#_9004fe2e_3e33_40f2_8037_ad576b5f6a04
type: Species
constant: false
is: SBO:0000252
name: RDH14
initial concentration: NaN
has only substance units: false
is encoded by: hsa:57665
is: Q9HBH5
initial amount: NaN
boundary condition: true

metaR 4HOXPACDOX NADP
is described by: ECO:0000304
modifier: MODEL1310110055#
reactant: MODEL1310110055#
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
product: MODEL1310110055#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
kinetic law: MODEL1310110055#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR r1557
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
kinetic law: MODEL1310110055#
is: SBO:0000185
product: MODEL1310110055#

metaM ocdca e
is: CHEBI:25629
constant: false
initial amount: NaN
type: Species
is: C01530
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
has only substance units: false
is: HMDB00827
name: octadecanoate (n-C18:0)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR S6T5g
product: MODEL1310110055#
is described by: ECO:0000000
modifier: MODEL1310110055#
type: Reaction
reversible: false
kinetic law: MODEL1310110055#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110055#
fast: false

metaR THD1m
is: SBO:0000185
modifier: MODEL1310110055#
name: NAD(P) transhydrogenase
kinetic law: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.6.1.2
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES:TDV (2-6-2003)
reactant: MODEL1310110055#
fast: false

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_c1126020_4f5f_49c3_8ce5_4978ad694550
initial concentration: NaN
initial amount: NaN
type: Species
name: AK2
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:204
constant: false

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR M16NTg
is: SBO:0000176
fast: false
type: Reaction
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.143
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
kinetic law: MODEL1310110055#
reversible: false
modifier: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#

metaR DCK2n
is: SBO:0000176
product: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
name: Deoxycytidine kinase, nuclear (UTP)
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.74
modifier: MODEL1310110055#

metaM cholcoads x
type: Species
initial concentration: 1.0
is: CHEBI:27505
is: HMDB06889
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460

metaM hexde7coa x
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB02288
boundary condition: false
type: Species
name: 7-hexadecenoylcoa
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_aa4e9c04_d7de_47e8_a046_03e51191c491
name: B3GNT3
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9Y2A9
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10331
constant: false

metaR FAOXC204C205x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C20:5)x
type: Reaction

metaR C140CPT1
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of myristoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_1463592b_7a44_4a36_91f8_2d56661905b1
is: O00462
name: MANBA
initial concentration: NaN
constant: false
is encoded by: hsa:4126
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species

metaR FAOXC160
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110055#
reversible: false
type: Reaction
modifier: MODEL1310110055#
is described by: ECO:0000269
product: MODEL1310110055#
name: Beta oxidation of long chain fatty acid
kinetic law: MODEL1310110055#

metaR PCHOLHSTDe
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: PCHOLHSTDe
type: Reaction

metaR SO4OXAtex2
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
type: Reaction
name: sulfate transport via oxalate countertransport (2:1)
reversible: false
product: MODEL1310110055#
is described by: ECO:0000304
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reactant: MODEL1310110055#

metaR SUBEACTD
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberic acid into cytosol (diffusion)
type: Reaction

metaM HC02214 e
initial concentration: 1.0
name: prostaglandin-f1alpha
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: SBO:0000247
is: CHEBI:28852

metaM cala c
is: HMDB00026
initial amount: NaN
name: N-carbamoyl-beta-alaninate
is: CHEBI:11892
is: SBO:0000247
type: Species
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false

metaR PHEyLATthc
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Phenylalanine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_1975f6e2_7e54_4dcd_9cd0_d5cb97fee47c
name: PTS
initial concentration: NaN
is encoded by: hsa:5805
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: Q03393
boundary condition: true

metaR r2420
kinetic law: MODEL1310110055#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
fast: false
reactant: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110055#

metaR CYTK13n
name: cytidylate kinase (dCMP,dATP),nuclear
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110055#
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110055#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_aae441f1_ff88_453b_a731_4663cf3d329a
type: Species
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:U37519
is: SBO:0000252
initial concentration: NaN
name: _U37519_1_c
initial amount: NaN

metaR ABTti
is described by: ECO:0000000
product: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#
name: L-arabinitol transport via passive diffusion
type: Reaction
is: SBO:0000185
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
fast: false

metaR GluForTx
kinetic law: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.5
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
type: Reaction
reversible: false
modifier: MODEL1310110055#
product: MODEL1310110055#
name: Glutamate formimidoyltransferase

http://identifiers.org/biomodels.db/MODEL1310110055#_ec4ec39f_9a60_419f_9dfb_5b2f717c7b5d
boundary condition: true
is: Q6ZMU0
constant: false
is encoded by: hsa:210
name: ALAD
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR 2HBt2
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
kinetic law: MODEL1310110055#
reversible: true
modifier: MODEL1310110055#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110055#
reactant: MODEL1310110055#
name: 2-hydroxybutyrate cotransport with proton

metaR sink tetdec2coa LPAREN c RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDEC2COASINK
type: Reaction

metaR MTRI
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 5.3.1.23 Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: 5-methylthioribose-1-phosphate isomerase
reversible: true
kinetic law: MODEL1310110055#
product: MODEL1310110055#
type: Reaction

metaR PEROXx
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
name: peroxisomal lumped long chain fatty acid oxidation
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
reactant: MODEL1310110055#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ

metaM hx2coa x
initial concentration: 1.0
name: trans-Hex-2-enoyl-CoA
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: C05998
constant: false
is: HMDB06870
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/11966188
type: Species

metaR ADSK
name: adenylyl-sulfate kinase
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
product: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.25
kinetic law: MODEL1310110055#
reversible: false
reactant: MODEL1310110055#

metaR FAOXC16OHC16r
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_62960977_85d8_432d_929d_d4ff862aa6bf
has part: Q5VYT2
is encoded by: hsa:4731
has only substance units: false
boundary condition: true
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:4712
is: SBO:0000297

metaM thcholoylcoa x
initial amount: NaN
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-8-9-30-36-31(12-15-48(29,30)6)47(5)14-11-28(56)19-27(47)20-33(36)58)7-10-32(57)26(2)45(63)79-18-17-50-35(59)13-16-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-34-39(74-76(64,65)66)38(60)44(73-34)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,26?,27+,28-,29-,30+,31+,32?,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
is: HMDB12456
is: CHEBI:27403
boundary condition: false
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
name: 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA
has only substance units: false

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

metaR NRPPHRtu
type: Reaction
product: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
name: Norepinephrine uniport

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaM 5tedtricoa x
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
type: Species
name: 5,8,11-tetradecatrienoylcoa
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB02288
boundary condition: false
is: SBO:0000247
constant: false

metaR EX 1glyc hs LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1 acyl phosphoglycerol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_1537089d_a3f8_4ced_a896_9080ead21650
name: PLD1
type: Species
is: Q59EA4
constant: false
boundary condition: true
is encoded by: hsa:5337
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_2c13615b_5c66_46be_bdfb_3e43f94c8eb2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
name: HYALP1
has only substance units: false
boundary condition: true
is encoded by: hsa:26062
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_f45c9c54_5e86_4b93_82e1_4f5eee8c8d3c
type: Species
initial amount: NaN
boundary condition: true
name: UGP2
is encoded by: hsa:7360
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_331b87e2_9ef1_4177_b8d0_41c09e3f2a8b
is: O95395
name: GCNT3
has only substance units: false
is: SBO:0000252
is encoded by: hsa:9245
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
type: Species

metaR r1556
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110055#
reactant: MODEL1310110055#

metaR 4NPHte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
fast: false
reversible: true
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000185
product: MODEL1310110055#
name: xenobiotic transport
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_17d06f56_235b_4451_a863_91ae7ec033cd
boundary condition: true
has only substance units: false
is encoded by: hsa:84701
is: SBO:0000252
is: Q96KJ9
name: COX4I2
type: Species
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_26380cc4_26a3_4a9b_8fe7_96a2b2c6d0b1
name: AKR1C4
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1109
is: P17516
is: SBO:0000252
boundary condition: true

metaM arachcoa c
is: HMDB04258
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: CHEBI:15527
has only substance units: false
name: arachidyl coenzyme A

metaM mi1p D n
type: Species
is: CHEBI:58433
name: 1D-myo-inositol 1-phosphate(2-)
is: HMDB02985
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM cytd m
is: SBO:0000247
boundary condition: false
name: cytidine
is: CHEBI:17562
initial amount: NaN
is: HMDB00089
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_271233b5_8624_4eb7_ab30_595967b67f9a
constant: false
is encoded by: hsa:3419
type: Species
boundary condition: true
initial concentration: NaN
name: IDH3A
is: SBO:0000252
has only substance units: false
is: P50213
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_2b68e605_712d_416e_99b1_12643f0652ed
boundary condition: true
constant: false
name: PRDX1
initial amount: NaN
is encoded by: hsa:5052
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: Q06830

http://identifiers.org/biomodels.db/MODEL1310110055#_f092025c_8da8_4717_bc91_d9db18d9da9f
is encoded by: hsa:126
has only substance units: false
constant: false
initial amount: NaN
has part: P00326
is: SBO:0000297
initial concentration: NaN
type: Species
name: ADH1B:ADH1C
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_c
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
is: SBO:0000247
has only substance units: false
is: HMDB00174
constant: false
type: Species
is: CHEBI:18287
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM dhap e
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:57642
initial concentration: 1.0
is: HMDB01473
name: glycerone phosphate(2-)
is: SBO:0000247
constant: false
boundary condition: false

metaM 56dthm m
has only substance units: false
boundary condition: false
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
is: SBO:0000247
name: 5,6-dihydrothymine
is: HMDB00079
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:27468

metaM nadp c
initial amount: NaN
has only substance units: false
is: CHEBI:58349
is: C00006
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate
is: HMDB00217
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
boundary condition: false
is: SBO:0000247
constant: false
type: Species

metaR r1566
reactant: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110055#_d798c6c6_2d49_4d1f_ab77_db7af179a596
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is: Q53XN1
is encoded by: hsa:1351
initial amount: NaN
initial concentration: NaN
name: COX8A

http://identifiers.org/biomodels.db/MODEL1310110055#_0e0c36f3_f8af_42c7_bc83_016d904409f1
boundary condition: true
name: SLC25A26
is encoded by: hsa:115286
is: Q70HW3
has only substance units: false
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is: SBO:0000252

metaM CE5101 m
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: CHEBI:57795
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
is: SBO:0000247
boundary condition: false

metaR GCCam
is version of: http://identifiers.org/ec-code/1.8.1.4
fast: false
is version of: http://identifiers.org/ec-code/1.4.4.2
reversible: true
kinetic law: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
name: glycine-cleavage complex (lipoylprotein), mitochondrial
is described by: ECO:0000269
product: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.1.2.10
reactant: MODEL1310110055#
is: SBO:0000176

metaR r1464
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110055#
name: Active transport
type: Reaction
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_d4c8cbfd_fa37_4a95_b3ee_f2d5b3990b4b
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI285872
name: _AI285872_1_c
initial amount: NaN
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_f9c1dde3_9190_42a8_98a3_f99d3e38e343
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: B4DK61
type: Species
boundary condition: true
name: ACOX1
is encoded by: hsa:51
constant: false
initial concentration: NaN

metaR GPDDA1
reactant: MODEL1310110055#
type: Reaction
fast: false
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.46 Confidence Level: 0 AUTHORS: NOTES:JLR
is described by: ECO:0000000
reversible: false
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
is: SBO:0000176
kinetic law: MODEL1310110055#

metaM ksi deg15 l
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00143
is: SBO:0000247
is: CHEBI:12936
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
name: keratan sulfate I, degradation product 15
boundary condition: false

metaM ksi pre1 g
boundary condition: false
is: SBO:0000247
notes: FORMULA: C79H129N5O57X CHARGE: -1
type: Species
initial amount: NaN
is: CHEBI:58053
is: C00130
constant: false
name: keratan sulfate I biosynthesis, precursor 1
is: HMDB00175
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_metaM_fucfucgalacglcgalacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
is: CHEBI:61648
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_62828f21_c1db_4d9c_92fa_99329273974e
boundary condition: true
has only substance units: false
initial amount: NaN
name: NDUFB1
constant: false
initial concentration: NaN
is encoded by: hsa:4707
is: O75438
is: SBO:0000252
type: Species

metaM man e
initial concentration: 1.0
initial amount: NaN
is: C00159
constant: false
name: D-Mannose
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:16024
is: HMDB00169
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159

metaM dhap c
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: C00111
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
name: Dihydroxyacetone phosphate
is: CHEBI:57642
is: HMDB01473
is: http://identifiers.org/pubchem.compound/3411

metaM ei11ecoa x
name: 11-eicosenoylcoa
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN
constant: false
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
type: Species
is: SBO:0000247

metaM oaa c
has only substance units: false
notes: FORMULA: C4H2O5 CHARGE: -2
initial concentration: 1.0
constant: false
is: CHEBI:3338
type: Species
boundary condition: false
name: Oxaloacetate
is: SBO:0000247
is: HMDB00223
initial amount: NaN
is: C00036

metaR r1565
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000185
reversible: true
fast: false

metaR S6T11g
modifier: MODEL1310110055#
is: SBO:0000176
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110055#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaM oxa c
is: HMDB02329
is: SBO:0000247
has only substance units: false
constant: false
name: oxalate(2-)
boundary condition: false
is: CHEBI:30623
initial concentration: 1.0
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial amount: NaN
type: Species

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

metaR RE2660N
reversible: true
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.96
name: RE2660
reactant: MODEL1310110055#
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
product: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_ab909e75_49de_4197_b6e9_02b71936e901
name: OCRL
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:4952
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_4544998c_60e5_4ce7_bff5_20a5afcb2f2d
has only substance units: false
name: _U37519_1_e
is encoded by: hsa:U37519
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM gthrd m
is: SBO:0000247
is: HMDB00125
boundary condition: false
constant: false
has only substance units: false
type: Species
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: CHEBI:57925
name: glutathionate(1-)
initial amount: NaN
initial concentration: 1.0

metaR PI4P3K
is version of: http://identifiers.org/ec-code/2.7.1.153
type: Reaction
is: SBO:0000176
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.1.154
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
product: MODEL1310110055#
reversible: false
name: phosphatidylinositol 4-phosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.11.1

http://identifiers.org/biomodels.db/MODEL1310110055#_7fb7ae84_1124_4c48_9903_dee20dbfc95a
is: SBO:0000252
type: Species
constant: false
is: O75715
has only substance units: false
initial amount: NaN
is encoded by: hsa:2880
initial concentration: NaN
name: GPX5
boundary condition: true

metaR ENGASE2ly
is described by: ECO:0000000
reactant: MODEL1310110055#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110055#
is: SBO:0000176
kinetic law: MODEL1310110055#
name: endo-beta-N-acetylglucosaminidase, lysosomal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_ebf939aa_13a6_45f9_b0b6_d3983c18104b
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:226
constant: false
boundary condition: true
has only substance units: false
name: ALDOA
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_f46a3757_2838_42de_a48d_645e77d5608f
name: ACAT2
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:39
is: SBO:0000252
is: Q9BWD1
initial amount: NaN
has only substance units: false

metaR TAGt
reactant: MODEL1310110055#
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000000
reversible: true
fast: false
name: triacylglycerol transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_b767908c_afea_49ca_89a5_0a7c58c4a8a6
initial concentration: NaN
has only substance units: false
is: P40926
initial amount: NaN
is encoded by: hsa:4191
boundary condition: true
constant: false
name: MDH2
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_9631c993_e425_429b_aae9_52636a98da57
boundary condition: true
name: AICDA
initial amount: NaN
constant: false
is encoded by: hsa:57379
is: SBO:0000252
type: Species
is: Q546Y9
has only substance units: false
initial concentration: NaN

metaR r1564
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#

metaR TTDCRNt
kinetic law: MODEL1310110055#
is: SBO:0000185
modifier: MODEL1310110055#
name: transport into the mitochondria (carnitine)
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110055#
fast: false
product: MODEL1310110055#
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR r0757
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is version of: http://identifiers.org/ec-code/3.5.4.16
modifier: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000176
fast: false
reactant: MODEL1310110055#

metaR G6PDH2rer
is described by: ECO:0000269
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.47
reactant: MODEL1310110055#
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
product: MODEL1310110055#
modifier: MODEL1310110055#
is: SBO:0000176
type: Reaction
reversible: true
fast: false

metaR AACOAT
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
reversible: true
modifier: MODEL1310110055#
name: Acetoacetyl-CoA:acetate CoA-transferase
is: SBO:0000176
reactant: MODEL1310110055#
product: MODEL1310110055#
fast: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/6.2.1.16

metaM xu5p D c
is: HMDB00868
constant: false
is: CHEBI:57737
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
name: D-xylulose 5-phosphate(2-)
is: SBO:0000247

metaM galside hs l
boundary condition: false
has only substance units: false
is: CHEBI:12947
initial amount: NaN
name: D-galactosyl-N-acylsphingosine
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
type: Species
constant: false

metaR CREATt4 2 r
kinetic law: MODEL1310110055#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110055#
is: SBO:0000185
reversible: true
fast: false
name: Creatine transport (sodium symport) (2:1)
reactant: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

metaM ppi n
boundary condition: false
name: diphosphate(3-)
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: CHEBI:33019
initial amount: NaN
has only substance units: false

metaR r2419
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110055#
is: SBO:0000185
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reactant: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#

metaR r1563
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
kinetic law: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110055#_a21106db_2346_49a3_95c5_231be80c204b
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:1593
initial concentration: NaN
constant: false
name: CYP27A1
is: SBO:0000252
is: Q02318
initial amount: NaN

metaM oxa e
is: HMDB02329
has only substance units: false
boundary condition: false
name: oxalate(2-)
type: Species
is: SBO:0000247
is: CHEBI:30623
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209

metaM man c
name: D-Mannose
initial amount: NaN
is: C00159
has only substance units: false
constant: false
boundary condition: false
type: Species
is: CHEBI:16024
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: HMDB00169
initial concentration: 1.0

metaM 42A3HP24DB c
is: http://identifiers.org/pubchem.compound/7956
has only substance units: false
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
is: C05645
boundary condition: false
type: Species
is: HMDB04083

metaR S6T4g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110055#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
fast: false
is: SBO:0000176
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#

metaR INSTt4 2
is described by: ECO:0000006
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
reactant: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
reversible: true
name: inositol transport via sodium symport
kinetic law: MODEL1310110055#
is: SBO:0000185
fast: false
modifier: MODEL1310110055#

metaR r1562
reactant: MODEL1310110055#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110055#
fast: false
product: MODEL1310110055#
type: Reaction

metaM fe3 e
is: HMDB12943
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
name: Fe3+
is: CHEBI:29034
initial concentration: 1.0
type: Species

metaM thym c
constant: false
is: C00178
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: CHEBI:17821
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00262
initial amount: NaN
name: Thymine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_d80574db_c5c6_40fc_868f_078633f41eee
initial concentration: NaN
is encoded by: hsa:10558
boundary condition: true
initial amount: NaN
has part: O15270
constant: false
is encoded by: hsa:9517
has only substance units: false
name: SPTLC1:SPTLC2
has part: O15269
is: SBO:0000297
type: Species

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

metaM sphings c
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:57756
initial concentration: 1.0
is: HMDB00252
constant: false
is: SBO:0000247
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
name: sphingosine(1+)

http://identifiers.org/biomodels.db/MODEL1310110055#_62453123_65ef_4b33_92d2_85e664491068
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:2180
initial amount: NaN
is: P33121
name: ACSL1
has only substance units: false
boundary condition: true

metaR r0755
fast: false
kinetic law: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
reversible: true
modifier: MODEL1310110055#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
product: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
type: Reaction

metaR r2202
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
modifier: MODEL1310110055#
is: SBO:0000185
fast: false
reversible: true

metaM galside hs e
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:12947
constant: false
initial amount: NaN
name: D-galactosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686

metaR TDCHOLAtx
is: SBO:0000185
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
reversible: true
product: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
fast: false

metaR r1561
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110055#
fast: false
product: MODEL1310110055#
reversible: true
reactant: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM gdpfuc c
constant: false
boundary condition: false
initial concentration: 1.0
name: GDP-L-fucose(2-)
has only substance units: false
is: HMDB01095
initial amount: NaN
is: CHEBI:57984
is: SBO:0000247
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
type: Species

metaM ksi deg26 l
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00061
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate I, degradation product 26
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
has only substance units: false
is: CHEBI:58343

metaR 2MB2COAc
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 2-methylcrotonoyl-CoA into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_419476b8_a8f4_411e_883c_349d358967e9
initial concentration: NaN
boundary condition: true
is: P45954
name: ACADSB
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:36

metaR FAS140COA
product: MODEL1310110055#
reversible: false
name: fatty-acyl-CoA synthase (n-C14:0CoA)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110055#
modifier: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_5c9dbc38_946b_475c_a095_a3eb790cd763
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:2348
name: FOLR1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_5d152194_c92d_4067_8ac6_985d2269bfec
initial concentration: NaN
has only substance units: false
boundary condition: true
name: ACOX1
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:51
is: Q15067

http://identifiers.org/biomodels.db/MODEL1310110055#_f81ff162_5fa4_4d0b_ad44_a0117c27f8d6
type: Species
is encoded by: hsa:6565
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: SLC15A2
is: Q16348
constant: false
has only substance units: false

metaM hom L c
name: L-homoserine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00719
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:15699

metaM c6dc c
type: Species
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C13H22NO6 CHARGE: -1
has only substance units: false
is: HMDB13130
initial amount: NaN
name: adipoyl carnitine
initial concentration: 1.0

metaR PIK3
type: Reaction
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.1.154
modifier: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.153
reversible: false
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
name: phosphatidylinositol 3-kinase
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.137
is described by: ECO:0000000

metaM 23dpg c
constant: false
is: HMDB01294
initial concentration: 1.0
name: 2,3-bisphosphonato-D-glycerate(5-)
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:58248
notes: FORMULA: C3H3O10P2 CHARGE: -5 INCHI: InChI=1S/C3H8O10P2/c4-3(5)2(13-15(9,10)11)1-12-14(6,7)8/h2H,1H2,(H,4,5)(H2,6,7,8)(H2,9,10,11)/p-5/t2-/m1/s1 EHMN_ABBREVIATION: C01159

metaM cdpdag hs c
boundary condition: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
type: Species
initial amount: NaN
is: CHEBI:58332
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
name: CDP-diacylglycerol(2-)

metaR r0756
is version of: http://identifiers.org/ec-code/3.1.3.1
modifier: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000176
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
reversible: true
product: MODEL1310110055#

metaR r1560
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110055#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_2bb7c0dc_0971_4b50_8b2a_939f4b81b5d5
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:5151
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
name: PDE8A

http://identifiers.org/biomodels.db/MODEL1310110055#_c4019ec3_9e18_4706_a22b_ce33678d0d1b
constant: false
is: SBO:0000252
type: Species
is: Q9P109
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: GCNT4
has only substance units: false
is encoded by: hsa:51301

http://identifiers.org/biomodels.db/MODEL1310110055#_0aa25328_b456_428f_aab8_6f7d27d227bf
name: INPP5D
is: Q92835
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:3635
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaM galside hs g
has only substance units: false
is: SBO:0000247
name: D-galactosyl-N-acylsphingosine
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: CHEBI:12947

http://identifiers.org/biomodels.db/MODEL1310110055#_d4135c86_1a3d_428a_962d_3b0a5e1e59a9
constant: false
type: Species
is: Q8IZV5
is: SBO:0000252
name: RDH10
is encoded by: hsa:157506
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM 34dhpha c
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
is: HMDB01336
initial concentration: 1.0
type: Species
name: (3,4-dihydroxyphenyl)acetate
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
is: CHEBI:17612

metaR GALt1r
reversible: true
reactant: MODEL1310110055#
is described by: ECO:0000269
name: galactose transport (uniport)
fast: false
is: SBO:0000185
product: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_b2678088_3bf3_45f8_a019_bb69d8b5e16f
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
name: PPA2
is: F8WDN9
is: SBO:0000252
constant: false
is encoded by: hsa:27068
has only substance units: false

metaR IDOAASE4ly
is described by: ECO:0000000
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.76
type: Reaction
modifier: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000176
fast: false
reversible: false
name: alpha-L-iduronidase, lysosomal

metaR r2200
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is described by: ECO:0000000
kinetic law: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#
reversible: true
fast: false

metaR r0753
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
reversible: true
product: MODEL1310110055#
fast: false
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reactant: MODEL1310110055#
is: SBO:0000176

metaR L LACt2r
is described by: ECO:0000269
reactant: MODEL1310110055#
name: L-lactate reversible transport via proton symport
is: SBO:0000185
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
fast: false
product: MODEL1310110055#
reversible: true

metaM ocde9ecoa x
constant: false
boundary condition: false
name: 9-octadecenoylcoa
is: http://identifiers.org/pubchem.compound/5280355
is: SBO:0000247
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_9e9fd046_f0f0_47c9_8fcb_8b25ced1cdb3
has only substance units: false
initial amount: NaN
constant: false
name: NAGA
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P17050
is encoded by: hsa:4668

http://identifiers.org/biomodels.db/MODEL1310110055#_57cf321d_fbed_4c66_b552_5ffe4f2d75ac
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4199
name: ME1
initial amount: NaN
is: SBO:0000252
is: P48163
constant: false
boundary condition: true
type: Species

metaR M13N2Tg
is version of: http://identifiers.org/ec-code/2.4.1.101
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
is: SBO:0000176
reversible: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110055#_5259dccc_e8e6_4379_af4c_3c3ed36f3fa2
is: Q92685
constant: false
name: ALG3
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10195
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_1b32ac48_e153_47b5_b97d_724bdbb51649
initial amount: NaN
name: _201288_1_c
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:201288

metaR THRGLNexR
product: MODEL1310110055#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110055#
is: SBO:0000185
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-threonine/glycine reversible exchange

metaR RDH2a
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.1.1.300
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.105
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
reactant: MODEL1310110055#
product: MODEL1310110055#
reversible: true
modifier: MODEL1310110055#
fast: false
name: retinol dehydrogenase (9-cis,NADPH)
is: SBO:0000176
type: Reaction

metaM hom L e
constant: false
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial amount: NaN
name: L-homoserine
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00719
type: Species
is: CHEBI:15699

metaM man g
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: SBO:0000247
has only substance units: false
is: CHEBI:16024
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
type: Species
is: HMDB00169
name: D-mannose

http://identifiers.org/biomodels.db/MODEL1310110055#_139aa18d_7a60_4d09_8d22_34e4d13c09eb
is encoded by: hsa:3420
name: IDH3B
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: O43837
is: SBO:0000252

metaR GALACGLCGALGBSIDEte
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
is described by: ECO:0000000
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000185
name: galacglcgalgbside hs transport
product: MODEL1310110055#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_d1ffd4f3_115d_442f_aad0_83d1d93436d0
boundary condition: true
initial amount: NaN
is encoded by: hsa:6575
initial concentration: NaN
has only substance units: false
constant: false
is: B2RBR4
is: SBO:0000252
name: SLC20A2
type: Species

metaR r2201
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_ee734c51_f0ae_4768_89ba_1cc43f919780
has only substance units: false
initial amount: NaN
name: NME3
is: SBO:0000252
is: Q13232
boundary condition: true
is encoded by: hsa:4832
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_6601aad3_41f4_4002_8d10_d833b0acdbc5
initial concentration: NaN
has only substance units: false
name: MTHFD1
is: SBO:0000252
is encoded by: hsa:4522
is: P11586
constant: false
type: Species
boundary condition: true
initial amount: NaN

metaR r0754
modifier: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
kinetic law: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
product: MODEL1310110055#
fast: false
is described by: ECO:0000000

metaM ppi r
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
constant: false
type: Species
is: C00013
is: CHEBI:33019
initial amount: NaN
name: Diphosphate
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_7a459657_ea3b_400c_afa1_847afeeec1d9
initial amount: NaN
is encoded by: hsa:2878
has only substance units: false
type: Species
initial concentration: NaN
is: P22352
constant: false
name: GPX3
is: SBO:0000252
boundary condition: true

metaM mthgxl c
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
initial concentration: 1.0
is: HMDB01167
type: Species
is: CHEBI:17158
name: methylglyoxal
has only substance units: false

metaR FUT911g
fast: false
product: MODEL1310110055#
reversible: false
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.4.1.152
modifier: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
name: Alpha-(1,3)-fucosyltransferase

http://identifiers.org/biomodels.db/MODEL1310110055#_635699bb_ff31_407d_987d_0099b6fa6bf1
is: P23921
initial concentration: NaN
name: RRM1
initial amount: NaN
is encoded by: hsa:6240
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
constant: false

metaM 4abut c
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0
constant: false
is: HMDB00112
name: 4-Aminobutanoate
initial concentration: 1.0
boundary condition: false
is: CHEBI:3628
type: Species
is: SBO:0000247
has only substance units: false
is: C00334

metaR ARACHDt2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: fatty acid transport via diffusion
kinetic law: MODEL1310110055#
type: Reaction

metaR AG13T18g
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110055#
reversible: false
type: Reaction
product: MODEL1310110055#
modifier: MODEL1310110055#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110055#
is: SBO:0000176
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_3b76ec5a_02e2_4e2e_a9d7_43e8eedbe4ea
has only substance units: false
initial amount: NaN
constant: false
name: SLC36A1
type: Species
is: SBO:0000252
is: Q1LZ56
boundary condition: true
is encoded by: hsa:206358
initial concentration: NaN

metaR GALASE14ly
reactant: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
fast: false
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110055#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR BILGLCURtr
reversible: true
product: MODEL1310110055#
is: SBO:0000185
fast: false
name: glucuronidated compound transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
is described by: ECO:0000000
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_4e9c4dae_382d_4733_a28e_a1d4f247830c
has only substance units: false
name: PFKFB2
is: O60825
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:5208

metaM c8dc x
initial amount: NaN
type: Species
notes: FORMULA: C15H26NO6 CHARGE: -1
is: SBO:0000247
initial concentration: 1.0
name: suberyl carnitine
boundary condition: false
is: HMDB00893
constant: false
has only substance units: false

metaM dhcholestancoa x
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
is: HMDB02159
is: CHEBI:15494
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_202eb249_72c2_4fb1_a106_8695b74da54e
type: Species
name: ALG3
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10195

metaR r1671
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
name: Y+LAT2 Utilized transport
is: SBO:0000185
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#

metaM man6p c
is: HMDB01078
is: CHEBI:17369
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
has only substance units: false
name: D-Mannose 6-phosphate
type: Species

metaR r0752
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
reversible: true
reactant: MODEL1310110055#
modifier: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000176
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
type: Reaction
kinetic law: MODEL1310110055#
is described by: ECO:0000000
fast: false

metaM galacglcgalgbside hs c
is: CHEBI:58343
constant: false
has only substance units: false
is: HMDB00061
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
name: Gal-GlcNAc-Gal globoside

metaM gdpfuc g
has only substance units: false
is: HMDB01095
boundary condition: false
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
name: GDP-L-fucose(2-)
constant: false
type: Species
is: SBO:0000247
is: CHEBI:57984
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_5593fa70_cc27_47c4_95c0_5d7e5c6e5371
name: NME1:NME2
has only substance units: false
constant: false
has part: P15531
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4830
is: SBO:0000297
is encoded by: hsa:4831
has part: P22392
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_1555a58e_cd22_40e5_a612_5d07067d372a
is encoded by: hsa:9498
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is: E7EML0
has only substance units: false
constant: false
name: SLC4A8
initial amount: NaN

metaR GALACGLCGALGBSIDEtg
name: galacglcgalgbside hs intracellular transport
product: MODEL1310110055#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
is described by: ECO:0000000
fast: false
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000185

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaR GPAM hs
product: MODEL1310110055#
reactant: MODEL1310110055#
modifier: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#
name: glycerol-3-phosphate acyltransferase
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.15
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (57678.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 2.3.1.15 Confidence Level: 4 AUTHORS: NOTES:NJ

metaM mi1p D c
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB02985
name: 1D-myo-inositol 1-phosphate(2-)
type: Species
is: SBO:0000247
constant: false
is: CHEBI:58433

metaR FAOXC121C10x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_e7609e3a_fefc_43f9_86e9_9007ca1e0ba5
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4843
is: P35228
has only substance units: false
initial amount: NaN
type: Species
name: NOS2

metaR HIVCACBP
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyisovalerylcoa from mitochondria into the cytosol
type: Reaction

metaR r1670
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110055#
fast: false
modifier: MODEL1310110055#
is described by: ECO:0000000
reversible: true
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110055#
reactant: MODEL1310110055#

metaR C226CRNt
name: C226 transport into the mitochondria
reversible: false
product: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is: SBO:0000185
reactant: MODEL1310110055#
is described by: ECO:0000000

metaM galside hs c
is: CHEBI:12947
name: D-galactosyl-N-acylsphingosine
type: Species
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial concentration: 1.0

metaM fe3 c
initial amount: NaN
is: HMDB12943
name: Fe3+
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: Fe CHARGE: 3
constant: false
has only substance units: false

metaM dump n
initial amount: NaN
is: HMDB01409
name: dUMP(2-)
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
boundary condition: false
has only substance units: false
is: CHEBI:246422
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_0264acea_b8a9_41e6_a21c_c15e0a3afea4
has only substance units: false
is encoded by: hsa:112
boundary condition: true
is: SBO:0000252
is: O43306
initial amount: NaN
constant: false
initial concentration: NaN
name: ADCY6
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_451d9d2b_b0ad_416e_aa42_e6c86aa59f93
name: NSDHL
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is: Q15738
boundary condition: true
is encoded by: hsa:50814

metaR ABO6g
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.37
reversible: false
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
product: MODEL1310110055#
fast: false
is described by: ECO:0000269
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
type: Reaction

metaM hdd2coa c
is: HMDB03945
has only substance units: false
name: trans-Hexadec-2-enoyl-CoA
boundary condition: false
is: CHEBI:61526
is: C05272
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR r0181
is version of: http://identifiers.org/ec-code/1.2.1.5
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110055#
is: SBO:0000176
kinetic law: MODEL1310110055#
product: MODEL1310110055#
type: Reaction

metaR FMNAT
reversible: false
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
kinetic law: MODEL1310110055#
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.7.2
name: FMN adenylyltransferase
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110055#_452844c4_57ab_4bce_8304_346612b59adc
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:6718
is: SBO:0000252
type: Species
has only substance units: false
is: P51857
initial concentration: NaN
name: AKR1D1

metaR 3HBCOAHLm
reversible: false
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
fast: false
is described by: ECO:0000000
reactant: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000176
type: Reaction

metaR ARACHDCOAtx
product: MODEL1310110055#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110055#
name: fatty acid intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false

metaM vitd3 c
initial amount: NaN
has only substance units: false
name: calciol
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
type: Species
is: CHEBI:28940
is: SBO:0000247
is: HMDB00876
boundary condition: false
constant: false

metaR RE2660C
reversible: true
reactant: MODEL1310110055#
type: Reaction
name: RE2660
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110055#_49b117a7_c328_4750_962b_e6659582f791
is encoded by: hsa:206
constant: false
type: Species
name: _206_1_c
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR AMETtd
product: MODEL1310110055#
name: diffusion of S-Adenosyl-L-methionine
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#

metaM hs deg24 l
is: CHEBI:16126
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
name: GlcNAc-GlcA-(Gal)2-Xyl
boundary condition: false
notes: FORMULA: C31H50NO26 CHARGE: -1

metaR NCNt
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000185
name: Na+/Ca2+-NH4+ exchange
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
modifier: MODEL1310110055#
reversible: true
kinetic law: MODEL1310110055#

metaM oxa m
type: Species
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial amount: NaN
name: oxalate(2-)
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB02329
is: CHEBI:30623

http://identifiers.org/biomodels.db/MODEL1310110055#_fcd19c45_c9a8_4ebe_b2d4_95f2c2434dde
name: _AA854479_1_m
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AA854479

metaR FAOXC183803m
product: MODEL1310110055#
is described by: ECO:0000000
modifier: MODEL1310110055#
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
fast: false
kinetic law: MODEL1310110055#
reversible: false
type: Reaction
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:3, n-3 -> c8:0 - 5 rounds of beta ox, lose 3 degrees of unsat - only 2 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaM gullac c
is: CHEBI:17587
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
boundary condition: false
has only substance units: false
name: L-gulono-1,4-lactone
is: HMDB03466
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_1e965dd5_f7b2_4dbe_ac2c_7f14a452fa65
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: ATP5J2
constant: false
is: P56134
is encoded by: hsa:9551
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_256de18f_e650_486c_b8b3_0a5ec7ed1ee9
constant: false
is encoded by: hsa:7991
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000297
initial concentration: NaN
initial amount: NaN

metaR r0750
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
is described by: ECO:0000000
reactant: MODEL1310110055#
product: MODEL1310110055#
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_4614a0a5_57e3_42fd_a856_dc17a158aece
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
name: PEMT
is encoded by: hsa:10400
initial amount: NaN
type: Species

metaR G3PD1
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.8
modifier: MODEL1310110055#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110055#
product: MODEL1310110055#
name: glycerol-3-phosphate dehydrogenase (NAD)
reactant: MODEL1310110055#
fast: false

metaR PSYTCHe
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of psyllium with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

metaR ARACHt
reactant: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
type: Reaction
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaR OIVD3m
reversible: false
name: 2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxopentanoate), mitochondrial
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.4.4
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.168
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.8.1.4

metaR GALASE1ly
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
reversible: false
modifier: MODEL1310110055#
is: SBO:0000176
kinetic law: MODEL1310110055#
name: beta-galactosidase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_93568b52_fc74_4df7_955b_e34f6e374ee9
is: Q549M5
initial concentration: NaN
boundary condition: true
name: NDUFC2
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:4718

metaM xol7ah3 c
is: HMDB12455
type: Species
name: 5beta-cholestane-3alpha,7alpha,26-triol
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
constant: false
has only substance units: false
is: CHEBI:28540
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_d5a422c3_fde8_4616_9cef_15be087492fa
name: PYCRL
boundary condition: true
is encoded by: hsa:65263
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is: Q53H96
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_dc9b0c6c_b955_43c3_a1aa_2355f19e0b87
has only substance units: false
name: PRPS1
initial concentration: NaN
is: SBO:0000252
is: P60891
constant: false
type: Species
boundary condition: true
is encoded by: hsa:5631
initial amount: NaN

metaM nac c
is: SBO:0000247
notes: FORMULA: C6H4NO2 CHARGE: -1
boundary condition: false
is: HMDB01488
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: C00253
constant: false
name: Nicotinate
type: Species
is: CHEBI:0

http://identifiers.org/biomodels.db/MODEL1310110055#_e9e585dd_58de_496f_86ad_0da130841d56
constant: false
type: Species
name: CA5A
boundary condition: true
initial amount: NaN
is encoded by: hsa:763
has only substance units: false
initial concentration: NaN
is: P35218
is: SBO:0000252

metaM ppi m
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
initial amount: NaN
is: CHEBI:33019
initial concentration: 1.0
name: Diphosphate
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
type: Species
is: C00013

metaR SERDGLNexR
name: D-Serine/Glutamine reversible exchange
reversible: true
type: Reaction
product: MODEL1310110055#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reactant: MODEL1310110055#

metaM vitd3 e
is: SBO:0000247
name: calciol
is: HMDB00876
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:28940

metaR UGT1A10r
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.17
type: Reaction
reversible: true
reactant: MODEL1310110055#
product: MODEL1310110055#
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal

metaM fad e
is: SBO:0000247
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial amount: NaN
is: C00016
constant: false
boundary condition: false
name: Flavin adenine dinucleotide oxidized
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:16238
is: HMDB01248

metaR r0908
name: Postulated transport reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
type: Reaction
reactant: MODEL1310110055#
reversible: true
kinetic law: MODEL1310110055#
is: SBO:0000185
fast: false
product: MODEL1310110055#

metaM thmtp c
type: Species
is: HMDB01512
notes: FORMULA: C12H16N4O10P3S CHARGE: -3 INCHI: InChI=1S/C12H19N4O10P3S/c1-8-11(30-7-16(8)6-10-5-14-9(2)15-12(10)13)3-4-24-28(20,21)26-29(22,23)25-27(17,18)19/h5,7H,3-4,6H2,1-2H3,(H5-,13,14,15,17,18,19,20,21,22,23)/p-3 EHMN_ABBREVIATION: C03028
is: CHEBI:58938
has only substance units: false
initial concentration: 1.0
name: thiamine(1+) triphosphate(4-)
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaM odecoa c
is: CHEBI:3793
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB01322
name: Octadecenoyl-CoA (n-C18:1CoA)

metaR r0603
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
product: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110055#
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
fast: false
type: Reaction
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.3.1.12

metaR DITPtn
type: Reaction
product: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false
name: dITP nuclear transport
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_28043107_5b99_40ee_800c_0b0ecce9f474
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: PIGW
is encoded by: hsa:284098
type: Species
boundary condition: true
is: Q7Z7B1
initial concentration: NaN

metaM gal14acglcgalgluside hs g
initial amount: NaN
constant: false
is: CHEBI:17103
is: SBO:0000247
boundary condition: false
name: Lactoneotetraosylceramide
initial concentration: 1.0
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
has only substance units: false
type: Species

metaR PSt3
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110055#
product: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
reversible: true
is described by: ECO:0000269
name: phosphatidylserine transport

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

metaR NACHEX9ly
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
is: SBO:0000176
modifier: MODEL1310110055#
product: MODEL1310110055#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#

metaR DM atp c
reversible: false
kinetic law: MODEL1310110055#
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110055#
fast: false
product: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
name: DM_atp(c)

metaM xylu L c
is: HMDB00751
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
boundary condition: false
initial amount: NaN
is: CHEBI:17399
name: L-xylulose
type: Species

metaR C6DCc
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoylcarnitine
type: Reaction

metaM 56dthm c
initial concentration: 1.0
is: CHEBI:27468
name: 5,6-dihydrothymine
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
has only substance units: false
is: HMDB00079
type: Species
constant: false
boundary condition: false

metaM 4abut e
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00112
constant: false
has only substance units: false
is: C00334
notes: FORMULA: C4H9NO2 CHARGE: 0
type: Species
initial concentration: 1.0
name: 4-Aminobutanoate
is: CHEBI:3628

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

metaR r0909
product: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
reversible: true
reactant: MODEL1310110055#
name: Transport reaction
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_1f506997_88c6_4fcb_96da_c8ec206634d1
name: GBA
initial amount: NaN
type: Species
is: B7Z6S1
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:2629

http://identifiers.org/biomodels.db/MODEL1310110055#_3da303c8_7b75_443b_9c4b_86a59395588b
boundary condition: true
is encoded by: hsa:158
name: ADSL
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_baca676b_54c8_46fc_9306_47484c71fb0a
constant: false
is: Q5QPH3
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
name: ACSS2
boundary condition: true
is encoded by: hsa:55902
is: SBO:0000252

metaM gpail hs c
is: SBO:0000247
is: CHEBI:17049
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
boundary condition: false
type: Species
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false

metaM thym m
boundary condition: false
type: Species
is: CHEBI:17821
initial amount: NaN
initial concentration: 1.0
name: thymine
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: HMDB00262
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_a233c31f_0eb1_4deb_a8e2_d81ddbe44604
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q9BYG0
type: Species
name: B3GNT5
is encoded by: hsa:84002

metaM galacglcgalgbside hs g
initial concentration: 1.0
is: CHEBI:26174
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: Gal-GlcNAc-Gal globoside
boundary condition: false
constant: false
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0

metaM cspg b e
constant: false
has only substance units: false
type: Species
is: HMDB00300
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: C00106
is: CHEBI:17568

http://identifiers.org/biomodels.db/MODEL1310110055#_4010fe86_db29_4d0a_ba28_b2c116cc5114
initial concentration: NaN
is: Q9BY07
has only substance units: false
constant: false
is encoded by: hsa:57835
boundary condition: true
is: SBO:0000252
name: SLC4A5
type: Species
initial amount: NaN

metaM fad c
is: C00016
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: Flavin adenine dinucleotide oxidized
is: HMDB01248
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: CHEBI:16238

metaR RE2759X
reversible: true
fast: false
modifier: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (23600.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:11060344,PMID:11060359 NOTES:
is version of: http://identifiers.org/ec-code/5.1.99.4
reactant: MODEL1310110055#
is described by: ECO:0000000
kinetic law: MODEL1310110055#
is: SBO:0000176
name: RE2759
type: Reaction

metaM prostge2 e
has only substance units: false
constant: false
boundary condition: false
is: HMDB01220
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
name: prostaglandin E2(1-)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:606564

metaR S2TASE2ly
is: SBO:0000176
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.1.6.13
fast: false
name: iduronate-2-sulfatase, lysosomal
reversible: false
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#

metaM galacglcgalgbside hs e
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00143
is: CHEBI:0
name: Gal-GlcNAc-Gal globoside
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
is: C00124
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_7f5d6f94_5ea3_45f3_818a_c00be68fcf83
is: P49914
name: MTHFS
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10588
type: Species
is: SBO:0000252

metaM thmtp e
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C12H16N4O10P3S CHARGE: -3 INCHI: InChI=1S/C12H19N4O10P3S/c1-8-11(30-7-16(8)6-10-5-14-9(2)15-12(10)13)3-4-24-28(20,21)26-29(22,23)25-27(17,18)19/h5,7H,3-4,6H2,1-2H3,(H5-,13,14,15,17,18,19,20,21,22,23)/p-3 EHMN_ABBREVIATION: C03028
is: HMDB01512
type: Species
is: CHEBI:58938
name: thiamine(1+) triphosphate(4-)
initial amount: NaN
constant: false
initial concentration: 1.0

metaR DESAT22 1p
product: MODEL1310110055#
type: Reaction
fast: false
reactant: MODEL1310110055#
is: SBO:0000176
kinetic law: MODEL1310110055#
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110055#_903bb131_11df_4bde_b01e_7b2a1c5c6f74
is: F8W1L5
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: GPD1
is encoded by: hsa:2819
type: Species
is: SBO:0000252

metaR NACHEXA10ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reversible: false
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
kinetic law: MODEL1310110055#
product: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_b2ce36d6_091f_4958_a16e_8acf49d502c8
name: _AA177072_1_x
type: Species
is encoded by: hsa:AA177072
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_1d178635_cf2e_49ef_84a2_19b6c7145fad
name: SLC43A1
initial amount: NaN
is: O75387
constant: false
type: Species
has only substance units: false
is encoded by: hsa:8501
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR EX coa LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for coa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_fba3511b_6f4d_4a52_a507_3a605f19e812
initial concentration: NaN
is: P14410
name: SI
type: Species
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:6476

http://identifiers.org/biomodels.db/MODEL1310110055#_metaR_ACGALFUCGALACGALFUC12GAL14ACGLCGALGLUSIDEte
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
product: MODEL1310110055#
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
reversible: true
name: blood group intracellular transport
type: Reaction

metaR UNK3
reversible: false
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:
is described by: ECO:0000000
name: 2-keto-4-methylthiobutyrate transamination

metaR r0680
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reactant: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110055#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.137
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
is described by: ECO:0000000

metaM gchola x
initial amount: NaN
name: glycocholate
is: SBO:0000247
notes: FORMULA: C26H43NO6 CHARGE: 0 INCHI: InChI=1S/C26H43NO6/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33)/p-1/t14-,15+,16-,17-,18+,19+,20-,21+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
constant: false
initial concentration: 1.0
is: HMDB00138
is: CHEBI:58235
type: Species
has only substance units: false
boundary condition: false

metaR EX 5mthf LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 5-Methyltetrahydrofolate
type: Reaction

metaR r2197
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110055#
product: MODEL1310110055#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
is: SBO:0000185
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110055#

metaR CYTK14n
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
name: cytidylate kinase (dCMP,CTP),nuclear
fast: false
modifier: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#

metaR RE1709C
fast: false
reactant: MODEL1310110055#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
name: RE1709
type: Reaction
kinetic law: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110055#_ff903ded_f154_4ca6_a6c4_5a70b9501355
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:5289
name: PIK3C3
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q8NEB9
initial concentration: NaN

metaM icit c
is: SBO:0000247
constant: false
is: HMDB00193
has only substance units: false
boundary condition: false
name: Isocitrate
is: CHEBI:16087
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
initial amount: NaN
initial concentration: 1.0
is: C00311
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_4cd99261_b9e4_4634_acfe_033e679b65e3
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:29880
is: Q9Y673
name: ALG5

metaR r0287
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
modifier: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction
reversible: false
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_c4b6dfb8_02c4_42f0_af86_39f8f76705f0
boundary condition: true
initial amount: NaN
is encoded by: hsa:1716
constant: false
has only substance units: false
name: DGUOK
type: Species
initial concentration: NaN
is: SBO:0000252

metaR F1Atg
type: Reaction
name: F1alpha transport (from golgi to lysosome)
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true
is: SBO:0000185

metaR PSSA1 hs
is version of: http://identifiers.org/ec-code/2.7.8.29
is: SBO:0000176
kinetic law: MODEL1310110055#
reversible: true
product: MODEL1310110055#
modifier: MODEL1310110055#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
reactant: MODEL1310110055#
is described by: ECO:0000269
name: Phosphatidylserine synthase homo sapiens

metaR r2198
reactant: MODEL1310110055#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true
fast: false
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#
is: SBO:0000185
type: Reaction

metaR S6T6g
reactant: MODEL1310110055#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110055#
modifier: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
reversible: false

metaM no c
type: Species
name: Nitric oxide
initial amount: NaN
has only substance units: false
is: HMDB03378
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
constant: false
is: SBO:0000247
is: C00533
is: CHEBI:16480
boundary condition: false
initial concentration: 1.0

metaR GLYCLTtp
kinetic law: MODEL1310110055#
name: glycolate transport into peroxisome
is described by: ECO:0000000
product: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
type: Reaction
reactant: MODEL1310110055#
is: SBO:0000185
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110055#_7418eb81_5b5c_44f8_bc6b_f928d2b51f1b
is: SBO:0000252
initial concentration: NaN
name: _22305_2_c
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:22305
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_metaM_acglc13galacglcgal14acglcgalgluside_hs_g
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0
is: SBO:0000247
has only substance units: false
name: nLc7Cer
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:26174

http://identifiers.org/biomodels.db/MODEL1310110055#_614b605f_4640_4247_b69e_72114024d358
name: _AU149534_1_c
type: Species
is encoded by: hsa:AU149534
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM guln c
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:13115
boundary condition: false
is: HMDB03290
name: L-gulonate
constant: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_a23f8088_02b7_4220_b518_0c4b8712c757
type: Species
is: P27708
boundary condition: true
initial amount: NaN
constant: false
name: CAD
is encoded by: hsa:790
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_c9b235f3_b101_40ab_b4f2_f48a9da1e352
initial concentration: NaN
name: DLD
boundary condition: true
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:1738
has only substance units: false
is: SBO:0000252
is: P09622

metaR 5MTHFt2
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (6573.1) or (6573.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:14770311 NOTES:IT
is described by: ECO:0000269
type: Reaction
product: MODEL1310110055#
name: 5-methyltetrahydrofolate transport via anion exchange
kinetic law: MODEL1310110055#
reversible: true
is: SBO:0000185
modifier: MODEL1310110055#
fast: false

metaM HC00695 m
type: Species
boundary condition: false
initial concentration: 1.0
name: S-Succinyldihydrolipoamide
constant: false
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
is: CHEBI:17432
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM glu L c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:29985
is: SBO:0000247
is: HMDB00148
type: Species
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
constant: false
name: L-glutamate(1-)

metaR r2195
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
product: MODEL1310110055#
reversible: true
is: SBO:0000185
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110055#_909aca81_0538_4356_b7f9_7454d6dc698f
initial concentration: NaN
is: Q96M32
initial amount: NaN
is encoded by: hsa:122481
is: SBO:0000252
type: Species
has only substance units: false
constant: false
name: AK7
boundary condition: true

metaR HSD17B4x
reactant: MODEL1310110055#
is described by: ECO:0000269
kinetic law: MODEL1310110055#
product: MODEL1310110055#
name: hydroxysteroid (17-beta) dehydrogenase 4
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
type: Reaction
modifier: MODEL1310110055#
reversible: false
fast: false

metaR GUAPRT
modifier: MODEL1310110055#
reactant: MODEL1310110055#
name: guanine phosphoribosyltransferase
reversible: false
is version of: http://identifiers.org/ec-code/2.4.2.8
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
is: SBO:0000176
kinetic law: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110055#_bd2a4e32_e8ae_4914_b3ad_925a108e6d3d
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:197257
name: LDHD

metaM 2obut m
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
name: 2-oxobutanoate
constant: false
is: SBO:0000247
is: HMDB00005
has only substance units: false
type: Species
is: CHEBI:16763
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR r0683
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
fast: false
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
product: MODEL1310110055#
is described by: ECO:0000000
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3

metaR G16MT L
reactant: MODEL1310110055#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
fast: false
product: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: false
name: Glycolipid 1,6-alpha-D-mannosyltransferase (liver)

metaR r2196
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
reversible: true
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110055#
is described by: ECO:0000000

metaM g2m8masn r
initial amount: NaN
boundary condition: false
is: C05874
constant: false
has only substance units: false
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C82H137N2O65X CHARGE: 0

metaR r2320
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110055#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000000

metaR r2433
reactant: MODEL1310110055#
is: SBO:0000185
kinetic law: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3

metaR EX prgstrn LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Progesterone exchange
type: Reaction

metaM ksi pre31 g
initial concentration: 1.0
has only substance units: false
is: HMDB00175
type: Species
boundary condition: false
constant: false
name: keratan sulfate I biosynthesis, precursor 31
is: C00130
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
is: SBO:0000247
is: CHEBI:58053
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_e4eb7f2b_38bd_488c_adb0_7042efc2d21c
has part: P10619
is encoded by: hsa:2588
is encoded by: hsa:4758
has part: P16278
constant: false
is encoded by: hsa:2720
is encoded by: hsa:5476
has part: P34059
is: SBO:0000297
boundary condition: true
name: GALNS:GLB1:NEU1:CTSA
type: Species
has only substance units: false
initial amount: NaN
has part: Q99519
initial concentration: NaN

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM prgnlone m
name: pregnenolone
constant: false
is: CHEBI:16581
initial concentration: 1.0
is: HMDB00253
has only substance units: false
initial amount: NaN
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953
type: Species
boundary condition: false
is: SBO:0000247

metaR DAGK hs
product: MODEL1310110055#
type: Reaction
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.107
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
modifier: MODEL1310110055#
is described by: ECO:0000269
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
name: Diacylglycerol phosphate kinase (homo sapiens)

http://identifiers.org/biomodels.db/MODEL1310110055#_a068a8f1_c0c0_414c_9746_b329868b6621
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
name: ACSS3
is: Q9H6R3
has only substance units: false
constant: false
is encoded by: hsa:79611

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

metaR B3GNT313g
reactant: MODEL1310110055#
is: SBO:0000176
kinetic law: MODEL1310110055#
fast: false
reversible: false
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
modifier: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus

metaR FAOXC121x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_48624b88_1728_4504_856a_985f47834d30
boundary condition: true
is encoded by: hsa:1609
constant: false
type: Species
name: DGKQ
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P52824

metaR r0539
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
kinetic law: MODEL1310110055#
fast: false
modifier: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.1.1.34
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19

metaM glu L e
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: L-glutamate(1-)
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: CHEBI:29985
type: Species
is: HMDB00148
has only substance units: false
is: SBO:0000247

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaR SPHK21c
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
type: Reaction
name: sphingosine kinase 2
is version of: http://identifiers.org/ec-code/2.7.1.91
is: SBO:0000176
product: MODEL1310110055#
is described by: ECO:0000269

metaR MI34PP
fast: false
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110055#
reversible: false
notes: GENE_ASSOCIATION: (3631.2) or (3631.1) or (8821.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:7608176,PMID:9295334 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.66
reactant: MODEL1310110055#
name: inositol-3,4-bisphosphate 4-phosphatase

metaM CE0785 m
has only substance units: false
is: CHEBI:57795
name: cis,cis-myristo-5,8-dienoyl-CoA
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785

metaM pail3p hs c
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:58088

http://identifiers.org/biomodels.db/MODEL1310110055#_08262487_1338_430b_b8ee_526bf2694f33
constant: false
is encoded by: hsa:AI222095
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
name: _AI222095_1_m

metaM cs b deg1 l
type: Species
is: CHEBI:57455
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
constant: false
initial concentration: 1.0
is: HMDB01354
has only substance units: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR r2435
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
reactant: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
product: MODEL1310110055#
is: SBO:0000185
kinetic law: MODEL1310110055#
reversible: false
fast: false

metaM ppcoa m
is: HMDB01275
type: Species
boundary condition: false
is: CHEBI:57392
initial concentration: 1.0
is: C00100
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: SBO:0000247
name: Propanoyl-CoA
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_086b362a_39f3_4ea9_bc7f_3c9fbed7b982
is: A4D0W4
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10157
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
type: Species
name: AASS

http://identifiers.org/biomodels.db/MODEL1310110055#_d93d12f6_00ae_4031_a274_80303d823523
name: PIGC
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:5279
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_84c18835_39c2_4e38_844c_afb24e78508c
type: Species
name: ALPL
is: B7Z4Y6
initial concentration: NaN
is encoded by: hsa:249
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252

metaR 4NPHSFte
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110055#
name: xenobiotic transport
product: MODEL1310110055#
fast: false
is described by: ECO:0000000

metaR FAEL204
fast: false
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
product: MODEL1310110055#
reversible: false
modifier: MODEL1310110055#
name: fatty-acyl-CoA elongation (n-C20:4CoA)

metaM 3octdece1crn e
name: 3-hydroxy-octadecenoyl carnitine
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C25H47NO5 CHARGE: 0
type: Species
is: HMDB02068
initial amount: NaN
constant: false

metaM tcynt m
constant: false
is: HMDB01453
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: CHEBI:18022
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: thiocyanate
type: Species

metaM xtsn c
type: Species
is: CHEBI:18107
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
has only substance units: false
name: xanthosine
is: SBO:0000247
is: HMDB00299
boundary condition: false
constant: false

metaR D3AIBTm
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
fast: false
is: SBO:0000176
product: MODEL1310110055#
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM

metaM ksi pre20 g
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 20
is: SBO:0000247
constant: false

metaR DOLPGT1 Ler
modifier: MODEL1310110055#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
product: MODEL1310110055#
reversible: false
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.4.1.267
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_a1ca69c9_849f_4d86_bbe4_85553ece4088
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P39656
name: DDOST
type: Species
is encoded by: hsa:1650
constant: false
is: SBO:0000252

metaM his L m
boundary condition: false
type: Species
initial concentration: 1.0
name: L-histidine
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: HMDB00177
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:15971
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_metaR_ACGALFUCGALACGALFUC12GAL14ACGLCGALGLUSIDEtg
type: Reaction
product: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is: SBO:0000185
name: blood group intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110055#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_0e7ff2ed_f0eb_4d7e_8e3e_ae072b3708ab
name: PRDX3
constant: false
is encoded by: hsa:10935
type: Species
is: SBO:0000252
is: E9PH29
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR r0892
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110055#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110055#
name: Facilitated diffusion
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.1.2.27
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:

metaR ATP1ter
is: SBO:0000185
name: ADP/ATP transporter, endoplasmic reticulum
fast: false
is described by: ECO:0000000
product: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#

metaM dolglcp L c
is: CHEBI:15812
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_6e791ff0_f496_4a24_be4c_3bcf9bc7f1ba
is: Q86WU2
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: LDHD
constant: false
is encoded by: hsa:197257
type: Species
boundary condition: true
initial concentration: NaN

metaR r2199
is described by: ECO:0000000
reactant: MODEL1310110055#
reversible: true
modifier: MODEL1310110055#
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_metaM_galacglcgal14acglcgalgluside_hs_g
boundary condition: false
initial amount: NaN
is: CHEBI:26174
initial concentration: 1.0
constant: false
name: i-antigen
type: Species
has only substance units: false
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_35b1b627_d1da_4930_a35e_e97525b0a6d9
is: Q9UJM8
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
name: HAO1
is encoded by: hsa:54363
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_a671ac3e_52b7_4106_a626_9991d3945302
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: Q16822
initial concentration: NaN
constant: false
name: PCK2
is encoded by: hsa:5106
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_96ae2fcc_f6ac_452c_b5cf_f8d38c0f1f05
name: NDUFS3
has only substance units: false
boundary condition: true
type: Species
is: O75489
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:4722
is: SBO:0000252

metaR PCHOL HSter
is described by: ECO:0000000
is: SBO:0000185
name: phosphatidylcholine scramblase
kinetic law: MODEL1310110055#
reversible: true
fast: false
type: Reaction
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
reactant: MODEL1310110055#

metaR EX gbside hs LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: globoside (homo sapiens) exchange
type: Reaction

metaM gullac r
initial concentration: 1.0
is: CHEBI:17587
constant: false
boundary condition: false
name: L-gulono-1,4-lactone
is: SBO:0000247
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
type: Species
is: HMDB03466
has only substance units: false
initial amount: NaN

metaM 3octdece1crn c
type: Species
is: SBO:0000247
is: HMDB00712
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C25H47NO5 CHARGE: 0
name: 3-hydroxy-octadecenoyl carnitine

metaR RE1845X
reactant: MODEL1310110055#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
modifier: MODEL1310110055#
name: RE1845
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false
product: MODEL1310110055#
type: Reaction
is described by: ECO:0000000

metaM pnto R e
is: CHEBI:7916
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00210
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: (R)-Pantothenate

metaR r1657
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110055#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_8c97d479_9044_4ecd_a177_c8efeb4973d5
is: Q86SR1
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:55568
boundary condition: true
constant: false
has only substance units: false
name: GALNT10

metaM dolglcp L r
has only substance units: false
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:15812
initial concentration: 1.0
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
type: Species
initial amount: NaN

metaM sprm e
is: HMDB01256
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
name: spermine(4+)
boundary condition: false
is: CHEBI:45725
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_3d6e1206_393b_4dbc_b15d_8c7ba9fc27ab
initial amount: NaN
constant: false
type: Species
boundary condition: true
name: HCST
is: SBO:0000252
initial concentration: NaN
is: Q9UBK5
is encoded by: hsa:10870
has only substance units: false

metaR GLUTCOAACBP
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of glutaryl-CoA(5-) from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_fee1d51a_85f8_497a_a765_883bf1dfadcb
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
name: PANK1
is encoded by: hsa:53354
is: Q8TE04
boundary condition: true

metaM CE2434 m
is: SBO:0000247
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:57795
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_92ebf450_bc91_4af3_aa58_f675fa8dde34
initial concentration: NaN
type: Species
is encoded by: hsa:5279
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:9091
has part: B2RAU6
constant: false
is encoded by: hsa:5277
is encoded by: hsa:51227
is: SBO:0000297
has part: P57054
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ

metaR C204CPT2
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
product: MODEL1310110055#
is: SBO:0000176
modifier: MODEL1310110055#
reversible: false
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
name: arachidonic acid transport into the mitochondria
type: Reaction
kinetic law: MODEL1310110055#

metaR ITCOALm
type: Reaction
modifier: MODEL1310110055#
is described by: ECO:0000212
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
fast: false
product: MODEL1310110055#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.5
is version of: http://identifiers.org/ec-code/6.2.1.4
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_8373817e_66f5_43b9_8200_99de2b68f56e
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252
boundary condition: true
name: _100128062_1_m
is encoded by: hsa:100128062

metaR r2325
fast: false
reactant: MODEL1310110055#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110055#
is: SBO:0000185
kinetic law: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true

metaM alpa hs c
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
constant: false
notes: FORMULA: C3H6O5PFULLRCO2 CHARGE: -2 INCHI: InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)
initial concentration: 1.0
is: CHEBI:52288
boundary condition: false
name: lysophosphatidic acid

http://identifiers.org/biomodels.db/MODEL1310110055#_61a90449_3729_4204_8101_e62cc16cdd32
constant: false
has part: P27986
is: SBO:0000297
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5295
name: PIK3CA:PIK3R1
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_a4f7773e_0ec5_4432_b8bb_00cb10f62a74
initial concentration: NaN
has only substance units: false
type: Species
is: Q92521
name: PIGB
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:9488

metaR r1656
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110055#
reversible: true
modifier: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
product: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM 3ddcrn c
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: 3-hydroxydodecanoylcarnitine
is: HMDB00623
has only substance units: false
notes: FORMULA: C19H37NO5 CHARGE: 0

metaM g3m8masn r
notes: FORMULA: C88H147N2O70X CHARGE: 0
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: C05873
has only substance units: false

metaM val L e
has only substance units: false
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: CHEBI:16414
is: HMDB00883
initial concentration: 1.0
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: SBO:0000247
name: L-valine

http://identifiers.org/biomodels.db/MODEL1310110055#_a880de0f_e73e_441f_a94f_1d3dc1671e54
is: Q5K4L6
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:11000
name: SLC27A3
type: Species
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_25b6cb0a_7fe6_44d2_afd8_902f7a1d00e5
is: P30043
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:645
initial concentration: NaN
name: BLVRB
has only substance units: false
constant: false
type: Species

metaR FACOAL170
fast: false
name: fatty-acid--CoA ligase
is described by: ECO:0000000
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
is: SBO:0000176
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
modifier: MODEL1310110055#
product: MODEL1310110055#
reversible: true

metaR FAS100COA
fast: false
kinetic law: MODEL1310110055#
name: fatty acyl-CoA synthase (n-C10:0CoA)
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reactant: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000269
type: Reaction

metaR LINKDEG4ly
reactant: MODEL1310110055#
name: degradation of proteoglycan linkage region, lysosomal
kinetic law: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_5a2bbfe6_0372_49f0_af3d_2a67e38b116b
has only substance units: false
constant: false
is encoded by: hsa:84720
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: PIGO
initial concentration: NaN
type: Species

metaM retinol 9 cis c
boundary condition: false
constant: false
type: Species
is: CHEBI:17336
initial concentration: 1.0
name: 9-cis-retinol
is: HMDB06217
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
initial amount: NaN

metaR r2326
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110055#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reactant: MODEL1310110055#
type: Reaction
is described by: ECO:0000000

metaR FAOXC2242046m
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of long chain fatty acid
fast: false
is: SBO:0000176
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110055#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#

metaM CE2705 n
has only substance units: false
initial concentration: 1.0
is: CHEBI:15374
initial amount: NaN
is: SBO:0000247
is: HMDB02281
name: quinonoid dihydrobiopterin
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
constant: false
boundary condition: false

metaM sprm c
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
is: HMDB01256
name: spermine(4+)
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:45725
constant: false

metaM gal1p c
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
is: CHEBI:58336
is: SBO:0000247
has only substance units: false
is: HMDB00645

metaR r1659
is described by: ECO:0000000
modifier: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110055#
reversible: true
kinetic law: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_6ae73874_d324_41d2_bf76_92535eaa67b2
initial concentration: NaN
type: Species
is encoded by: hsa:4539
is: SBO:0000252
constant: false
initial amount: NaN
name: ND4L
is: Q7GXZ4
boundary condition: true
has only substance units: false

metaM dhea r
is: HMDB00077
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
is: CHEBI:28689
initial concentration: 1.0
type: Species
constant: false
name: 3beta-hydroxyandrost-5-en-17-one
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_a311bb28_0adc_41f2_a9b0_7b85a5345c07
type: Species
is: Q9NR34
initial amount: NaN
is encoded by: hsa:57134
has only substance units: false
name: MAN1C1
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252

metaR RE2626C
reversible: true
product: MODEL1310110055#
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
name: RE2626
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

metaR r2327
product: MODEL1310110055#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false

metaR RE1709N
type: Reaction
reactant: MODEL1310110055#
modifier: MODEL1310110055#
name: RE1709
fast: false
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
is: SBO:0000176
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/4.2.1.96

metaM betald c
initial amount: NaN
is: SBO:0000247
constant: false
name: betaine aldehyde
is: CHEBI:15710
boundary condition: false
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
has only substance units: false
type: Species
is: HMDB01252
initial concentration: 1.0

metaR r1658
product: MODEL1310110055#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110055#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_e61f62fa_0a09_4a29_ae34_02699fcceb79
initial concentration: NaN
name: ND6
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is: Q7GXZ1
is encoded by: hsa:4541

metaM val L c
type: Species
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:16414
initial concentration: 1.0
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: HMDB00883
name: L-valine
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_7b9fdee0_fb38_4d2e_8cd8_d1ce70235320
is: SBO:0000252
constant: false
initial concentration: NaN
name: VNN3
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:55350

metaR DM anth
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_18a57a00_8da8_46d6_bdb4_7d2381e93edd
initial concentration: NaN
constant: false
boundary condition: true
name: FUK
is: Q8N0W3
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:197258
initial amount: NaN

metaM HC01406 m
name: 3-Oxooctanoyl-CoA
boundary condition: false
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28264
has only substance units: false

metaM cs a deg3 l
is: SBO:0000247
is: CHEBI:15748
initial amount: NaN
notes: FORMULA: C31H48NO32S2 CHARGE: -3
has only substance units: false
is: HMDB00127
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
boundary condition: false
type: Species
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_88f916ef_16d5_40eb_9b0c_1bf667747566
has only substance units: false
is: Q8TBF5
boundary condition: true
name: PIGX
type: Species
initial amount: NaN
is encoded by: hsa:54965
constant: false
is: SBO:0000252
initial concentration: NaN

metaR r2328
is: SBO:0000185
fast: false
product: MODEL1310110055#
kinetic law: MODEL1310110055#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110055#

metaM HC00718 c
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
name: N-methylethanolaminium phosphate(1-)
type: Species
initial concentration: 1.0
is: CHEBI:57781

metaR COAtr
name: COA transporter, endoplasmic reticulum
type: Reaction
reactant: MODEL1310110055#
fast: false
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
kinetic law: MODEL1310110055#
is: SBO:0000185
reversible: true

metaR r2193
is described by: ECO:0000000
modifier: MODEL1310110055#
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: true
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaM glyald c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB01051
is: CHEBI:17378
initial amount: NaN
boundary condition: false
name: D-Glyceraldehyde
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: C00577
type: Species

metaR r2321
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110055#
is: SBO:0000185

metaR r0531
is version of: http://identifiers.org/ec-code/1.1.1.34
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110055#
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
reactant: MODEL1310110055#
product: MODEL1310110055#
fast: false
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110055#

metaR r1653
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110055#
reversible: true
product: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110055#_830c79b8_1dad_4d15_90db_57212ae4196f
is encoded by: hsa:35
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
is: P16219
initial concentration: NaN
name: ACADS

metaM cit c
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00094
initial amount: NaN
is: C00158
is: CHEBI:16947
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
type: Species
name: Citrate

http://identifiers.org/biomodels.db/MODEL1310110055#_0a7b7c37_a880_408c_ac14_8a78aea044ac
initial amount: NaN
is: Q9H310
is encoded by: hsa:57127
has only substance units: false
initial concentration: NaN
name: RHBG
is: SBO:0000252
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_5e2a340c_6ed7_42d9_a459_57fc217baf06
is encoded by: hsa:84532
name: ACSS1
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q9NUB1
type: Species

metaR EX galgalgalthcrm hs LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer (homo sapiens) exchange
type: Reaction

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaM odecoa m
is: HMDB01322
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57387
type: Species
initial amount: NaN
boundary condition: false
name: Octadecenoyl-CoA (n-C18:1CoA)

metaM but e
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00039
initial amount: NaN
boundary condition: false
name: butyrate
type: Species
is: CHEBI:17968
is: SBO:0000247
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246

metaR r2194
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110055#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction

metaR r0899
product: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110055#
reversible: true
name: Amino acid transporter ATB0+ Facilitated diffusion

metaR r2322
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000185
product: MODEL1310110055#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM CE5853 e
notes: FORMULA: C22H29O10 CHARGE: -1 INCHI: InChI=1/C22H30O10/c1-9-10(2)18-12(11(3)14(9)24)5-7-22(4,32-18)8-6-13(23)30-21-17(27)15(25)16(26)19(31-21)20(28)29/h15-17,19,21,24-27H,5-8H2,1-4H3,(H,28,29)/p-1/t15-,16+,17-,19-,21+,22?/m1/s1 EHMN_ABBREVIATION: CE5853
initial amount: NaN
name: alpha-CEHC-glucuronide
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:57923
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_c028de83_933a_45d2_b9f0_afc7a4418c43
constant: false
type: Species
is encoded by: hsa:3612
name: IMPA1
initial concentration: NaN
has only substance units: false
is: B7Z6Q4
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR r1652
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110055#
product: MODEL1310110055#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110055#

metaR r0130
type: Reaction
is: SBO:0000176
reversible: true
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110055#
kinetic law: MODEL1310110055#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
modifier: MODEL1310110055#

metaR ACETONEt2m
fast: false
product: MODEL1310110055#
name: acetone mitochondrial transport via proton symport
reversible: true
modifier: MODEL1310110055#
is described by: ECO:0000000
kinetic law: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110055#
is: SBO:0000185

metaR COAtp
name: coenzyme A transport, peroxisomal
product: MODEL1310110055#
fast: false
type: Reaction
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaR FAOXC200180m
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110055#
fast: false
name: Beta oxidation of long chain fatty acid
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
modifier: MODEL1310110055#

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaR r1655
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110055#
modifier: MODEL1310110055#
fast: false
type: Reaction

metaR r2323
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110055#
product: MODEL1310110055#

metaR r0791
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reactant: MODEL1310110055#
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM cit e
name: citrate(3-)
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00094
is: SBO:0000247
is: CHEBI:16947
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
has only substance units: false
boundary condition: false
type: Species

metaR NACHEXA12ly
is described by: ECO:0000000
modifier: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
name: beta-N-acetylhexosaminidase A, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reversible: false
type: Reaction
kinetic law: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110055#

metaR G14T4g
modifier: MODEL1310110055#
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR N2M2NMASNtly
reactant: MODEL1310110055#
name: n2m2nmasn transport, extracellular to lysosome
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000185
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110055#_7078acf5_bfa2_462b_839c_1e9f055b3912
initial concentration: NaN
has only substance units: false
name: SLC16A7
is encoded by: hsa:9194
boundary condition: true
initial amount: NaN
is: Q8NEM3
is: SBO:0000252
type: Species
constant: false

metaM but c
constant: false
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
initial concentration: 1.0
is: CHEBI:17968
has only substance units: false
type: Species
is: HMDB00039
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: butyrate

metaR DNDPt26m
is described by: ECO:0000269
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dCDP transport via dUDP antiport
reversible: false
fast: false
is: SBO:0000185
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
product: MODEL1310110055#

metaM C05965 e
is: HMDB04243
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
has only substance units: false
type: Species
name: 12(S)-HPETE(1-)
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:57444

metaM 3ddcrn e
notes: FORMULA: C19H37NO5 CHARGE: 0
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00791
is: C02838
name: 3-hydroxydodecanoylcarnitine
initial concentration: 1.0
has only substance units: false

metaR r1654
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
modifier: MODEL1310110055#
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_a9836d49_6a7b_4e7c_9066_4578e964167c
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: PIK3CD
boundary condition: true
constant: false
is: A7E2E0
is encoded by: hsa:5293
has only substance units: false

metaM ppcoa x
is: C00100
has only substance units: false
name: Propanoyl-CoA
is: CHEBI:57392
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
boundary condition: false
is: HMDB01275
type: Species

metaR r2324
product: MODEL1310110055#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110055#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110055#

metaR r0792
modifier: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000176
type: Reaction
reversible: true
kinetic law: MODEL1310110055#
is described by: ECO:0000000
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
reactant: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107

http://identifiers.org/biomodels.db/MODEL1310110055#_025b3a32_b972_4480_bc05_6205484d8047
initial amount: NaN
is encoded by: hsa:341947
initial concentration: NaN
type: Species
is: Q7Z4L0
has only substance units: false
constant: false
name: COX8C
boundary condition: true
is: SBO:0000252

metaM mi4p D c
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: 1D-myo-inositol 4-phosphate(2-)
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3-,4+,5-,6-/m0/s1
is: HMDB01313
is: CHEBI:58469
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_6ed6d387_6274_415b_8368_ccdddb476d77
initial amount: NaN
boundary condition: true
name: ALG8
is encoded by: hsa:79053
is: Q9BVK2
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false

metaR TCHOLAte
kinetic law: MODEL1310110055#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110055#
reactant: MODEL1310110055#
name: bile acid intracellular transport
type: Reaction
fast: false

metaR RE3381E
is: SBO:0000176
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
product: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290,PMID:10690708,PMID:11087858,PMID:11818531 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.31
name: RE3381

http://identifiers.org/biomodels.db/MODEL1310110055#_ad54b0f6_f115_4bd0_abd9_70eb150a0507
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: ETFB
is: P38117
is encoded by: hsa:2109
initial amount: NaN
type: Species
constant: false
boundary condition: true

metaM cspg a e
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
has only substance units: false
is: C00106
is: HMDB00300
initial amount: NaN
type: Species
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:17568

metaM val L m
is: HMDB00883
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: CHEBI:16414
initial concentration: 1.0
name: L-valine
has only substance units: false
is: SBO:0000247
constant: false
type: Species

metaM acgam1p c
is: CHEBI:7125
has only substance units: false
is: HMDB01367
constant: false
name: N-Acetyl-D-glucosamine 1-phosphate
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_f6dc2513_e271_4ea8_9ebe_6bd46cd8f753
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:412
initial concentration: NaN
constant: false
name: STS
is: P08842
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_3ccff254_5ba4_4327_a158_7b665831d51a
boundary condition: true
name: DBT
type: Species
is: SBO:0000252
has only substance units: false
is: P11182
is encoded by: hsa:1629
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_0f4c41fd_8016_4694_a89d_1c7f52004e2c
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: P14854
initial concentration: NaN
type: Species
is: SBO:0000252
name: COX6B1
is encoded by: hsa:1340

metaR r0782
kinetic law: MODEL1310110055#
is: SBO:0000176
name: GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) Fructose and mannose metabolism EC:1.1.1.271
type: Reaction
reactant: MODEL1310110055#
is described by: ECO:0000000
fast: false
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: PMID:10410995,PMID:2428310,PMID:9603974 NOTES:
reversible: false

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaR r1660
reactant: MODEL1310110055#
modifier: MODEL1310110055#
fast: false
product: MODEL1310110055#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110055#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_f2c16cd2_4fb0_4964_8d16_c0a8eaba93e0
is: SBO:0000252
constant: false
has only substance units: false
is: Q6IA69
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:55191
name: NADSYN1
type: Species
boundary condition: true

metaR S6TASE2ly
is described by: ECO:0000000
reactant: MODEL1310110055#
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
is: SBO:0000176
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14

http://identifiers.org/biomodels.db/MODEL1310110055#_e41e1448_cbbc_469a_96a4_7dcfbea78f01
has only substance units: false
name: GPX6
is encoded by: hsa:257202
constant: false
initial amount: NaN
is: SBO:0000252
is: P59796
type: Species
initial concentration: NaN
boundary condition: true

metaM fprica c
is: CHEBI:58467
boundary condition: false
is: C04734
is: HMDB01439
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
type: Species

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_97336cf2_79d6_4e1f_8826_2cf884b1646f
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: SLC23A1
is encoded by: hsa:9963
has only substance units: false
type: Species

metaR IZPN
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110055#
type: Reaction
is: SBO:0000176
fast: false
reversible: false
product: MODEL1310110055#
is described by: ECO:0000000
name: Imidazolonepropionase

metaR NCKt
type: Reaction
fast: false
kinetic law: MODEL1310110055#
reversible: true
reactant: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
product: MODEL1310110055#
is described by: ECO:0000269
modifier: MODEL1310110055#
name: Na+/Ca2+-K+ exchange

http://identifiers.org/biomodels.db/MODEL1310110055#_fe8a882b_a892_4321_aa94_3f558f27ac5a
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: GCK
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2645
type: Species

metaR RE2626M
product: MODEL1310110055#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
type: Reaction
modifier: MODEL1310110055#
name: RE2626
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110055#
fast: false

metaR r0781
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
reversible: true
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
is described by: ECO:0000000
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110055#_68a7b3ff_8a65_4a65_98f5_fb0b87812167
constant: false
type: Species
name: _LOC374569_1_e
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:LOC374569
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_d100f291_e5a4_4485_ad88_f4f1beab22f5
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:23530
initial amount: NaN
has only substance units: false
name: NNT

metaR r1661
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110055#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110055#
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110055#
product: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR GGT6
reversible: true
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
reactant: MODEL1310110055#
name: Gamma-glutamyltransferase
kinetic law: MODEL1310110055#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaR TDCRNe
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of myristoyl carnitine into extra cellular space
type: Reaction

metaM ddece1crn e
constant: false
boundary condition: false
type: Species
name: dodecenoyl carnitine
initial concentration: 1.0
is: SBO:0000247
is: HMDB02250
notes: FORMULA: C19H35NO4 CHARGE: 0
has only substance units: false
initial amount: NaN

metaM hs deg10 l
is: SBO:0000247
is: CHEBI:15748
name: heparan sulfate, degradation product 10
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00127
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
boundary condition: false
has only substance units: false
type: Species

metaM prostgf2 c
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB01139
is: SBO:0000247
constant: false
type: Species
name: prostaglandin F2alpha(1-)
is: CHEBI:57404

http://identifiers.org/biomodels.db/MODEL1310110055#_12c16c39_82a5_4ede_a9a4_dec5308f0a95
initial concentration: NaN
is: SBO:0000252
name: HKDC1
boundary condition: true
has only substance units: false
constant: false
is: B3KT70
is encoded by: hsa:80201
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_777821eb_caa8_4c39_a709_fbfcd1ecc377
is encoded by: hsa:50
type: Species
constant: false
initial amount: NaN
name: ACO2
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q99798
initial concentration: NaN

metaR GLCNACASE1ly
fast: false
product: MODEL1310110055#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
name: alpha-N-acetylglucosaminidase, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.50
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_c5f69da0_0257_4b14_a50e_96840846d5ae
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:5832
has only substance units: false
is: SBO:0000252
name: ALDH18A1
is: P54886

metaR PSDm hs
modifier: MODEL1310110055#
is described by: ECO:0000269
name: Phosphatidylserine decarboxylase
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
product: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/4.1.1.65
type: Reaction
is: SBO:0000176
reactant: MODEL1310110055#
fast: false

metaM andrstandn r
type: Species
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
is: CHEBI:15994
is: HMDB00899
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: 5alpha-androstane-3,17-dione
constant: false

metaR DPMVDc
reversible: false
kinetic law: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added t product for elemental balancing.
name: diphosphomevalonate decarboxylase, cytosol
is version of: http://identifiers.org/ec-code/4.1.1.33
product: MODEL1310110055#
reactant: MODEL1310110055#
modifier: MODEL1310110055#
fast: false
is described by: ECO:0000134
type: Reaction

metaR r1662
fast: false
modifier: MODEL1310110055#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110055#
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_8d3e4c57_72b6_4723_9beb_c909b2eb6934
is: SBO:0000252
name: COASY
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:80347
is: Q13057
has only substance units: false

metaR B3GALT3g
product: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.4.1.79
reactant: MODEL1310110055#
is described by: ECO:0000269
kinetic law: MODEL1310110055#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
name: Beta-1,3-galactosyltransferase 3
fast: false
is: SBO:0000176

metaR r0784
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
product: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.38
is described by: ECO:0000000
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
reactant: MODEL1310110055#
reversible: true
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
type: Reaction

metaM prpp c
name: 5-Phospho-alpha-D-ribose 1-diphosphate
type: Species
is: CHEBI:58017
initial concentration: 1.0
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
constant: false
initial amount: NaN
is: C00119
is: SBO:0000247
is: HMDB00280
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_e39c7d71_7753_4ebb_a3f4_e56570784590
is: Q9HBF5
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
name: ST20
initial amount: NaN
has only substance units: false
is encoded by: hsa:400410
type: Species

metaR FALDH
modifier: MODEL1310110055#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.1
fast: false
kinetic law: MODEL1310110055#
is described by: ECO:0000269
name: formaldehyde dehydrogenase
type: Reaction
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
is: SBO:0000176
product: MODEL1310110055#
reactant: MODEL1310110055#

metaR HMBS
is version of: http://identifiers.org/ec-code/2.5.1.61
reactant: MODEL1310110055#
reversible: false
is described by: ECO:0000254
product: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
name: hydroxymethylbilane synthase
notes: GENE_ASSOCIATION: (3145.1) SUBSYSTEM: Heme synthesis EC Number: 4.3.1.8 Confidence Level: 2 AUTHORS: PMID:2875434 NOTES:
is: SBO:0000176
modifier: MODEL1310110055#
fast: false

metaR 34DHXMANDACOX
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110055#
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
is: SBO:0000176
reversible: false
type: Reaction

metaM ala L c
has only substance units: false
is: CHEBI:16977
initial amount: NaN
name: L-alanine
constant: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: HMDB00161
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_faafd695_8b3b_43a4_96d5_12d475167ec5
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:51109
type: Species
name: RDH11
is: SBO:0000252
is: B4DDW0

metaR N4Tg
reactant: MODEL1310110055#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110055#
fast: false
reversible: false
name: N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD

http://identifiers.org/biomodels.db/MODEL1310110055#_abdd26ac_2e8d_4e69_9506_0dd626f86f24
has only substance units: false
is: P19801
initial concentration: NaN
type: Species
is encoded by: hsa:26
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
name: ABP1

http://identifiers.org/biomodels.db/MODEL1310110055#_45569ea2_940e_4f8d_8a55_5f4e235d2410
initial concentration: NaN
has only substance units: false
type: Species
name: ACSL6
is encoded by: hsa:23305
initial amount: NaN
constant: false
is: B2RB13
boundary condition: true
is: SBO:0000252

metaR C12DCACT
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of Dodecanedioic acid
type: Reaction

metaR r0783
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reactant: MODEL1310110055#
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110055#_a8c24912_f3e5_4e33_bdd2_e74d87ddbe1a
name: PIP4K2A
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5305
has only substance units: false
is: P48426
constant: false
boundary condition: true
initial concentration: NaN
type: Species

metaR HS3ly
reversible: false
name: heparan-N-sulfatase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.10.1.1
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
reactant: MODEL1310110055#
is: SBO:0000176
product: MODEL1310110055#

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

metaM h2o2 x
type: Species
is: SBO:0000247
name: Hydrogen peroxide
has only substance units: false
is: C00027
is: CHEBI:16240
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial amount: NaN
boundary condition: false
is: HMDB03125
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_e9007b8b_62f8_4572_a277_8bda9452b509
type: Species
is encoded by: hsa:223
boundary condition: true
constant: false
initial amount: NaN
name: ALDH9A1
is: SBO:0000252
has only substance units: false
is: P49189
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_8a96fd47_fa81_4fc3_949c_716549f2c0cb
initial concentration: NaN
is encoded by: hsa:10400
initial amount: NaN
constant: false
name: PEMT
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true

metaR ABO7g
product: MODEL1310110055#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.37
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
fast: false
is: SBO:0000176
kinetic law: MODEL1310110055#
reversible: false
modifier: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction

metaM HC01231 m
constant: false
type: Species
name: N-[(R)-pantothenoyl]-L-cysteinate
is: CHEBI:58480
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
initial amount: NaN
has only substance units: false

metaM thbpt4acam n
name: 4a-hydroxytetrahydrobiopterin
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:15374
constant: false
boundary condition: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
initial concentration: 1.0
is: HMDB02281

metaM datp c
type: Species
constant: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
name: dATP
is: HMDB01532
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C00131
initial concentration: 1.0
is: CHEBI:61404
boundary condition: false

metaR CYTK1m
product: MODEL1310110055#
reversible: true
is described by: ECO:0000134
is: SBO:0000176
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
type: Reaction
fast: false
name: cytidylate kinase (CMP),mitochondrial
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_ce21a3d9_8e4c_47b8_828f_01f816665b80
name: PDE8B
constant: false
is encoded by: hsa:8622
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: O95263

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_4ae00479_3d2d_4e8f_8c14_1c1fcef25245
boundary condition: true
type: Species
is: P30838
has only substance units: false
initial amount: NaN
name: ALDH3A1
is encoded by: hsa:218
constant: false
initial concentration: NaN
is: SBO:0000252

metaR r2318
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
product: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_8d2c4b12_4c11_420a_bc90_7dccff59c2b6
has only substance units: false
type: Species
constant: false
is encoded by: hsa:1629
is: SBO:0000252
initial amount: NaN
name: DBT
initial concentration: NaN
is: P11182
boundary condition: true

metaM pchol hs e
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16110
initial amount: NaN
name: Phosphatidylcholine
boundary condition: false

metaM gchola e
initial amount: NaN
type: Species
is: HMDB00138
initial concentration: 1.0
notes: FORMULA: C26H43NO6 CHARGE: 0
boundary condition: false
is: SBO:0000247
constant: false
name: glycocholate
has only substance units: false

metaR CYTK1n
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110055#
type: Reaction
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
fast: false
name: cytidylate kinase (CMP),nuclear

http://identifiers.org/biomodels.db/MODEL1310110055#_0494195b_8aa1_44ef_adde_208ec39818c2
name: BPNT1
is: O95861
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10380
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false

metaM vacccoa c
is: HMDB06521
is: http://identifiers.org/pubchem.compound/9543677
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: vaccenyl coenzyme A
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1

metaR B3GNT36g
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110055#
product: MODEL1310110055#
fast: false

metaR r2317
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110055#
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_83fa3e75_f70a_43c4_b142_c2e14fced801
has only substance units: false
is encoded by: hsa:767
constant: false
type: Species
initial concentration: NaN
boundary condition: true
name: CA8
initial amount: NaN
is: SBO:0000252
is: P35219

metaR FAS160COA
type: Reaction
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
reactant: MODEL1310110055#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
kinetic law: MODEL1310110055#
product: MODEL1310110055#
fast: false
name: fatty-acyl-CoA synthase (n-C16:0CoA)
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110055#_cfeb688e_9087_4376_adf3_27fae308a1c9
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AA526438
type: Species
boundary condition: true
name: _AA526438_1_m
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_3d4de2cd_a630_4952_a67b_683d813d667b
is encoded by: hsa:51079
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is: Q9P0J0
name: NDUFA13
initial concentration: NaN

metaM 3aib D m
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
constant: false
is: C03265
name: D-3-Amino-isobutanoate
type: Species
initial amount: NaN
is: HMDB02299
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_284cb379_91cc_43d8_b94a_52293535f989
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:11254
has only substance units: false
initial amount: NaN
is: Q9UN76
constant: false
type: Species
name: SLC6A14

metaM guln r
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
name: L-gulonate
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
is: HMDB03290
is: CHEBI:13115
type: Species

metaR S4TASE3ly
name: N-acetylgalactosamine-4-sulfatase, lysosomal
fast: false
reversible: true
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
product: MODEL1310110055#
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.1.6.12
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_151913b3_ec6b_4937_a2b6_0ddde935a0b6
initial concentration: NaN
boundary condition: true
name: ALDH1L1
type: Species
is encoded by: hsa:10840
is: O75891
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false

metaR LCTStg
type: Reaction
name: lactose transport from Golgi to extracellular (via vesicle)
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:this reaciton is only found in lactating mammary cells NCD
product: MODEL1310110055#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110055#
reversible: false
is described by: ECO:0000000

metaR GALASE6ly
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
modifier: MODEL1310110055#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110055#
reactant: MODEL1310110055#

metaR IDOAASE3ly
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
reversible: false
is described by: ECO:0000000
product: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.76
name: alpha-L-iduronidase, lysosomal
type: Reaction

metaM memgacpail hs r
is: SBO:0000247
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
initial amount: NaN
is: CHEBI:15809
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
boundary condition: false

metaM pchol hs c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
name: Phosphatidylcholine
constant: false
boundary condition: false
is: CHEBI:16110

metaM gchola c
initial amount: NaN
type: Species
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
initial concentration: 1.0
is: HMDB00138
boundary condition: false
name: glycocholate
is: CHEBI:58235
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_02702d34_9377_428c_bff7_d56623b9c33d
boundary condition: true
name: _AI373818_1_m
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:AI373818
constant: false

metaR r0788
modifier: MODEL1310110055#
product: MODEL1310110055#
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: true
fast: false
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
reactant: MODEL1310110055#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110055#_9c7fe9b0_4509_4db5_be06_789b3aa6ecb1
initial amount: NaN
is: SBO:0000252
name: HAS2
type: Species
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3037
is: Q92819

metaM ksii core2 deg9 l
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 9
type: Species
constant: false
notes: FORMULA: C30H50N3O20X CHARGE: 0
initial amount: NaN
is: CHEBI:12936
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00143

metaR 10FTHFtm
reactant: MODEL1310110055#
is: SBO:0000185
reversible: true
fast: false
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
type: Reaction
product: MODEL1310110055#
is described by: ECO:0000000
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_d520fb4f_7937_4fc2_bb91_d459070cb0ed
has part: P23921
has part: P31350
is encoded by: hsa:6241
is: SBO:0000297
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: NaN
name: RRM1:RRM2
boundary condition: true
is encoded by: hsa:6240

metaM inost c
initial concentration: 1.0
is: CHEBI:17268
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
initial amount: NaN
name: myo-inositol
constant: false
type: Species
is: HMDB00211

metaR r2319
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110055#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110055#
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_967839a2_8140_4ca0_8e5f_c22f82b32035
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: Q8WZ48
is encoded by: hsa:1374
is: SBO:0000252
name: CPT1A

metaM ddece1crn c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: dodecenoyl carnitine
type: Species
notes: FORMULA: C19H35NO4 CHARGE: 0
boundary condition: false
is: HMDB03712
constant: false
initial amount: NaN

metaR HSAT1ly
fast: false
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reversible: false

metaM cys L e
is: CHEBI:17561
is: SBO:0000247
name: L-cysteine
has only substance units: false
type: Species
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00574
initial concentration: 1.0

metaM c16dc c
has only substance units: false
notes: FORMULA: C23H42NO6 CHARGE: -1
is: SBO:0000247
constant: false
name: Hexadecanedioic acid mono-L-carnitine ester
is: HMDB00712
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN

metaR ACGAMtly
type: Reaction
reactant: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
name: N-acetyl-glucosamine lysosomal efflux
product: MODEL1310110055#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110055#
fast: false

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaR DSREDUCr
name: Desmosterol reductase
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.3.1.72
reactant: MODEL1310110055#
type: Reaction
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110055#
product: MODEL1310110055#
fast: false

metaM prostgf2 e
name: prostaglandin F2alpha(1-)
initial amount: NaN
boundary condition: false
type: Species
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: HMDB01139
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57404

metaM pnto R c
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
name: (R)-Pantothenate
is: CHEBI:7916
is: HMDB00210

metaR r0787
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
kinetic law: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
type: Reaction
reversible: false
modifier: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.1

metaM cit m
is: C00158
name: Citrate
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
constant: false
is: HMDB00094
is: CHEBI:16947

metaM btn e
type: Species
is: SBO:0000247
is: C00120
notes: FORMULA: C10H15N2O3S CHARGE: -1
constant: false
initial concentration: 1.0
boundary condition: false
name: Biotin
is: HMDB00030
initial amount: NaN
is: CHEBI:3420
has only substance units: false

metaR HDECEACBP
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecenoylcoa from mitochondria into the cytosol
type: Reaction

metaM ksi deg30 l
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I, degradation product 30
constant: false
is: CHEBI:12936
boundary condition: false
type: Species
is: HMDB00143
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
has only substance units: false

metaR r1050
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
name: Vesicular transport
product: MODEL1310110055#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000185

metaR EX ddecrn
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lauroyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_64e2f13e_1f0f_46f1_8433_474b400b086f
has only substance units: false
name: PDE4A
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5141
initial concentration: NaN
is: P27815
constant: false
type: Species

metaM ksi deg17 l
is: CHEBI:12936
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
is: HMDB00143
boundary condition: false
name: keratan sulfate I, degradation product 17

metaM rbt c
is: CHEBI:15963
boundary condition: false
initial amount: NaN
name: D-ribitol
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
initial concentration: 1.0
type: Species
is: HMDB00508
has only substance units: false
is: SBO:0000247

metaM thymd c
type: Species
constant: false
is: SBO:0000247
name: Thymidine
initial amount: NaN
has only substance units: false
is: CHEBI:17748
is: C00214
is: HMDB00273
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214

http://identifiers.org/biomodels.db/MODEL1310110055#_72577c01_2d23_488c_ae2a_ac970d1f720d
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:NOS2A
name: _NOS2A_1_e
boundary condition: true

metaR CERT2rt
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110055#
modifier: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
kinetic law: MODEL1310110055#
name: ceramide transport protein
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110055#

metaR NACHEX22ly
product: MODEL1310110055#
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110055#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
fast: false
reactant: MODEL1310110055#
modifier: MODEL1310110055#

metaR SUBERCACT
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberyl carnitine into cytosol
type: Reaction

metaR r0789
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
type: Reaction
product: MODEL1310110055#
fast: false
is: SBO:0000176
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:

metaM 2obut c
initial amount: NaN
is: HMDB00005
boundary condition: false
is: C00109
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
name: 2-Oxobutanoate
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:16763
type: Species

metaM arach c
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: HMDB02212
initial concentration: 1.0
is: CHEBI:32360
is: SBO:0000247
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
name: arachidate

metaR r1051
kinetic law: MODEL1310110055#
type: Reaction
name: Vesicular transport
is: SBO:0000185
fast: false
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110055#

metaR r0129
is described by: ECO:0000000
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
product: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
reversible: true
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.1.40
fast: false
is: SBO:0000176
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_b5b39865_488a_4803_9b89_a4afa84a2bc2
type: Species
is: Q6IB80
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: NDUFB3
is encoded by: hsa:4709

metaM c16dc e
notes: FORMULA: C23H42NO6 CHARGE: -1
has only substance units: false
is: HMDB00712
initial amount: NaN
name: Hexadecanedioic acid mono-L-carnitine ester
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_f1c6055e_2160_4ab0_97c0_476e79277e32
initial amount: NaN
boundary condition: true
is: P23921
is: SBO:0000252
name: RRM1
constant: false
is encoded by: hsa:6240
initial concentration: NaN
has only substance units: false
type: Species

metaM HC02179 c
boundary condition: false
name: 20-hydroxy-arachidonate
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:34306
type: Species
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: SBO:0000247
has only substance units: false

metaR CYSGLYexR
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reversible: true
product: MODEL1310110055#
name: L-cysteine/glycine reversible exchanger
reactant: MODEL1310110055#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_f27a682d_5cd6_46fc_b0d7_a2eca3f59cf9
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:953
is: Q86VV3
constant: false
name: ENTPD1
has only substance units: false

metaR TYRCBOX
name: L-Tyrosine carboxy-lyase
type: Reaction
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
fast: false
reactant: MODEL1310110055#
is described by: ECO:0000134
product: MODEL1310110055#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/4.1.1.28

http://identifiers.org/biomodels.db/MODEL1310110055#_ee4aa640_1370_4300_8703_e3128a412ff9
is encoded by: hsa:1723
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: Q02127
constant: false
name: DHODH
initial amount: NaN
has only substance units: false

metaM btn c
is: HMDB00030
is: SBO:0000247
initial concentration: 1.0
name: Biotin
boundary condition: false
has only substance units: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
type: Species
constant: false
initial amount: NaN
is: CHEBI:3420
is: C00120

metaM rbt e
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: HMDB00508
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:15963
name: D-ribitol
constant: false

metaM cys L c
is: HMDB00574
is: CHEBI:17561
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
name: L-cysteine
boundary condition: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099

metaM thbpt4acam c
initial concentration: 1.0
boundary condition: false
is: CHEBI:15374
has only substance units: false
type: Species
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
name: 4a-hydroxytetrahydrobiopterin
constant: false
is: SBO:0000247
is: HMDB02281
initial amount: NaN

metaM cspg a l
is: SBO:0000247
has only substance units: false
is: CHEBI:36005
initial amount: NaN
type: Species
constant: false
is: HMDB02183
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
boundary condition: false
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
initial concentration: 1.0

metaM pchol hs r
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:16110
has only substance units: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
is: SBO:0000247
name: Phosphatidylcholine

http://identifiers.org/biomodels.db/MODEL1310110055#_e5466a8f_87e3_4ee3_8379_a294add53df4
constant: false
name: ACSL5
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:51703
type: Species
is: SBO:0000252
is: Q9ULC5

http://identifiers.org/biomodels.db/MODEL1310110055#_6a23ed1b_1757_46ee_909b_d6c263eca6dc
initial amount: NaN
type: Species
constant: false
is: Q15392
is: SBO:0000252
boundary condition: true
name: DHCR24
is encoded by: hsa:1718
has only substance units: false
initial concentration: NaN

metaM inost e
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
has only substance units: false
is: CHEBI:17268
name: myo-inositol
is: HMDB00211
is: SBO:0000247
initial amount: NaN

metaR THRCYSNaEx
is: SBO:0000185
product: MODEL1310110055#
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110055#
is described by: ECO:0000269
modifier: MODEL1310110055#
type: Reaction
name: L-cysteine/L-threonine Na-dependent exchange (Thr-L in)
kinetic law: MODEL1310110055#
fast: false

metaM CE1926 e
is: SBO:0000247
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
constant: false
name: gama-carboxyethyl-hydroxychroman
is: CHEBI:15748
initial concentration: 1.0
is: HMDB00127
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_5f52748f_d468_4f6d_990e_f88adc0612a9
is: A8K460
is encoded by: hsa:8398
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: PLA2G6
boundary condition: true
initial concentration: NaN
constant: false

metaM dhea c
is: HMDB00077
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
is: CHEBI:28689
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
name: 3beta-hydroxyandrost-5-en-17-one

http://identifiers.org/biomodels.db/MODEL1310110055#_e94011e9_895e_4314_b425_a9d2a8c4ace3
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:26279
is: Q9UNK4
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
type: Species
name: PLA2G2D

metaR RE3273C
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
is: SBO:0000176
product: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
name: RE3273
reversible: true
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.1.4.4
is described by: ECO:0000000
fast: false

metaR r0679
reversible: true
product: MODEL1310110055#
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
fast: false
is: SBO:0000176

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaR BILIRUBtr
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
reactant: MODEL1310110055#
is: SBO:0000185
product: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: true
name: lipid, flip-flop intracellular transport
fast: false

metaR LNLCCRNt
name: transport into the mitochondria (carnitine)
product: MODEL1310110055#
modifier: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110055#
is: SBO:0000185
kinetic law: MODEL1310110055#
reversible: false
fast: false
is described by: ECO:0000269

metaR HSD17B1
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.62
fast: false
is: SBO:0000176
name: testicular 17-beta-hydroxysteroid dehydrogenase
reactant: MODEL1310110055#
reversible: true
modifier: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (3292.1) or (7923.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 4 AUTHORS: PMID:12943747 NOTES:direct enzymatic rates quantified in human brain tissue
kinetic law: MODEL1310110055#
product: MODEL1310110055#

metaR ST8SIA12
product: MODEL1310110055#
type: Reaction
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.99.8
name: Beta-galactoside alpha-2,3-sialyltransferase
kinetic law: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
reactant: MODEL1310110055#
modifier: MODEL1310110055#
reversible: false

metaR CAATPS
name: Ca ATPase
product: MODEL1310110055#
reactant: MODEL1310110055#
reversible: false
is version of: http://identifiers.org/ec-code/3.6.3.8
type: Reaction
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
modifier: MODEL1310110055#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110055#
is described by: ECO:0000269

metaM elaidcrn c
is: HMDB06464
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
has only substance units: false
name: Elaidic carnitine
boundary condition: false

metaR NRVNCt
reversible: true
product: MODEL1310110055#
name: fatty acid transport via diffusion
is: SBO:0000185
reactant: MODEL1310110055#
is described by: ECO:0000000
kinetic law: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction

metaM ksi pre15 g
is: HMDB00175
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:58053
is: C00130
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 15
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_cd9130f7_a553_47eb_a68e_7e9258d5ec6c
is: SBO:0000252
is: P54750
has only substance units: false
is encoded by: hsa:5136
initial concentration: NaN
name: PDE1A
constant: false
initial amount: NaN
boundary condition: true
type: Species

metaM creat c
is: CHEBI:16919
name: creatine
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: SBO:0000247
is: HMDB00064

metaM tcynt c
type: Species
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
constant: false
initial concentration: 1.0
is: HMDB01453
boundary condition: false
name: thiocyanate
initial amount: NaN
is: SBO:0000247
is: CHEBI:18022
has only substance units: false

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_ac9b919a_c37d_4cb1_93f3_ef2156d10c97
constant: false
initial concentration: NaN
is: P16278
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:2720
has only substance units: false
boundary condition: true
name: GLB1

metaR r0127
is: SBO:0000176
reversible: false
is described by: ECO:0000000
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.38 Confidence Level: 0 AUTHORS: PMID:4311065,PMID:4894450 NOTES:
modifier: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
name: L-Asparagine amidohydrolase Alanine and aspartate metabolism / Cyanoamino acid metabolism / Nitrogen metabolism EC:3.5.1.1 EC:3.5.1.38
is version of: http://identifiers.org/ec-code/3.5.4.16
type: Reaction
kinetic law: MODEL1310110055#

metaR NACHEXA15ly
is described by: ECO:0000000
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110055#
name: beta-N-acetylhexosaminidase A, lysosomal
kinetic law: MODEL1310110055#
type: Reaction

metaR DMHPTCRNCPT2
kinetic law: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
product: MODEL1310110055#
reversible: true
name: 2,6 dimethylheptanoly CoA carnitine transferase
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:made reversible since Keq ~ 0.6. dmhptcoa is a special case because its biochemical fate has not be elucidated. NJ
fast: false

metaM glyald m
has only substance units: false
is: HMDB01051
name: D-glyceraldehyde
is: CHEBI:17378
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577

metaM hs deg25 l
is: SBO:0000247
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
notes: FORMULA: C23H37O21 CHARGE: -1
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: CHEBI:16126
has only substance units: false

metaM HC02179 e
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:34306
name: 20-hydroxy-arachidonate
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_78422845_3878_496b_b370_082a6b7ee14f
type: Species
boundary condition: true
constant: false
is encoded by: hsa:AGPAT7
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: _AGPAT7_1_c

metaR 3MOX4HOXPGALDOX NADP
modifier: MODEL1310110055#
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase
fast: false
type: Reaction
reactant: MODEL1310110055#
reversible: true
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110055#_8b0a0d86_5b4b_4ecb_bac9_6951a29474e2
type: Species
is encoded by: hsa:1588
name: CYP19A1
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is: P11511

http://identifiers.org/biomodels.db/MODEL1310110055#_76e4114e_7f27_4c34_9a80_0aa0a16b5a82
type: Species
is encoded by: hsa:AA526438
name: _AA526438_1_c
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252

metaM pmtcrn x
is: SBO:0000247
name: L-palmitoylcarnitine
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: HMDB00222
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: CHEBI:17490
boundary condition: false

metaM dec24dicoa x
initial concentration: 1.0
name: 2,4-decadienoylcoa
is: SBO:0000247
constant: false
is: HMDB01168
boundary condition: false
type: Species
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
has only substance units: false
initial amount: NaN

metaR ST8SIA11
name: Beta-galactoside alpha-2,3-sialyltransferase
is described by: ECO:0000000
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000176
modifier: MODEL1310110055#
reversible: false
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.4.99.8
type: Reaction
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
fast: false

metaM arach e
initial concentration: 1.0
is: SBO:0000247
is: HMDB02212
constant: false
initial amount: NaN
name: arachidate
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:32360
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102

metaM pristanal c
initial amount: NaN
notes: FORMULA: C19H38O CHARGE: 0 INCHI: InChI=1S/C19H38O/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20/h15-19H,6-14H2,1-5H3
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:49189
constant: false
type: Species
name: pristanal
is: HMDB01958

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR FE3MTP1
name: transport of ferrous iron into blood
fast: false
reactant: MODEL1310110055#
product: MODEL1310110055#
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
type: Reaction
kinetic law: MODEL1310110055#
reversible: false
is: SBO:0000185
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110055#_64347ab1_8eda_4a24_a023_eeb8001f34aa
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:51022
constant: false
boundary condition: true
type: Species
has only substance units: false
is: Q9NS18
name: GLRX2

http://identifiers.org/biomodels.db/MODEL1310110055#_2abfb521_3b53_4502_8701_4f79af2e83fa
initial concentration: NaN
has only substance units: false
is: O43181
initial amount: NaN
boundary condition: true
is encoded by: hsa:4724
name: NDUFS4
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_353f9b6f_c916_4da1_afcf_58b83d2c3151
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:91373
boundary condition: true
type: Species
name: UAP1L1
is: Q3KQV9

metaR BAAT1x
fast: false
name: bile acid Coenzyme A: amino acid N-acyltransferase
product: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
reversible: false
modifier: MODEL1310110055#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110055#

metaM chito2pdol L c
has only substance units: false
notes: FORMULA: C1240H2028N20O170P20 CHARGE: -20 INCHI: InChI=1S/C41H72N2O17P2/c1-25(2)13-9-14-26(3)15-10-16-27(4)17-11-18-28(5)19-12-20-29(6)21-22-55-61(51,52)60-62(53,54)59-41-35(43-31(8)47)38(50)39(33(24-45)57-41)58-40-34(42-30(7)46)37(49)36(48)32(23-44)56-40/h13,15,17,19,29,32-41,44-45,48-50H,9-12,14,16,18,20-24H2,1-8H3,(H,42,46)(H,43,47)(H,51,52)(H,53,54)/b26-15+,27-17+,28-19-/t29?,32-,33-,34-,35-,36-,37-,38-,39-,40+,41-/m1/s1
is: HMDB01196
is: SBO:0000247
constant: false
type: Species
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human liver homolog
initial concentration: 1.0
is: CHEBI:12427
boundary condition: false
initial amount: NaN

metaM pchol hs m
initial concentration: 1.0
type: Species
name: Phosphatidylcholine
boundary condition: false
constant: false
is: CHEBI:16110
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
has only substance units: false

metaR EX tetdece1crn
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecenoyl carnitine
type: Reaction

metaM prpp e
constant: false
has only substance units: false
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
is: SBO:0000247
type: Species
is: CHEBI:58017
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: HMDB00280
initial amount: NaN

metaM octa c
notes: FORMULA: C8H15O2 CHARGE: -1
type: Species
initial amount: NaN
is: CHEBI:25646
constant: false
has only substance units: false
boundary condition: false
is: HMDB00482
name: octanoate (n-C8:0)
is: C06423
initial concentration: 1.0
is: SBO:0000247

metaR SIAASE2ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110055#
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110055#
reactant: MODEL1310110055#
name: sialidase, lysosomal
is described by: ECO:0000000
fast: false

metaR TCHOLAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
name: bile acid intracellular transport
type: Reaction
is described by: ECO:0000000
product: MODEL1310110055#
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
is: SBO:0000185

metaM tcynt e
name: thiocyanate
type: Species
is: SBO:0000247
is: CHEBI:18022
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB01453
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755

metaM creat e
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: creatine
initial concentration: 1.0
is: HMDB00064
type: Species
constant: false
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: CHEBI:16919

metaR EX 34hpp
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_53977966_8287_41f6_a5c6_0586df409169
is encoded by: hsa:AI222095
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: _AI222095_1_e
is: SBO:0000252
type: Species
boundary condition: true

metaM glu L m
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: L-glutamate(1-)
boundary condition: false
is: HMDB00148
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: CHEBI:29985

metaR DNDPt8m
is: SBO:0000185
modifier: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000269
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dADP transport via dUDP antiport
kinetic law: MODEL1310110055#
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_5ae56cb1_289b_404d_b5a0_e16ea674c743
type: Species
initial concentration: NaN
is encoded by: hsa:55808
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q9NSC7
constant: false
name: ST6GALNAC1

http://identifiers.org/biomodels.db/MODEL1310110055#_dc5f9794_7f37_4659_8588_3c95bc39f690
is encoded by: hsa:80339
initial amount: NaN
is: SBO:0000252
constant: false
name: PNPLA3
type: Species
boundary condition: true
is: Q9NST1
initial concentration: NaN
has only substance units: false

metaM pan4p c
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB01416
name: Pantetheine 4'-phosphate
has only substance units: false
type: Species
is: C01134
boundary condition: false
is: CHEBI:47942
initial concentration: 1.0
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134

metaM pail34p hs c
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:57658
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)

metaM 3hpp m
is: SBO:0000247
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
is: CHEBI:16510
type: Species
name: 3-hydroxypropionate
constant: false
is: HMDB00700
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR TRDRm
product: MODEL1310110055#
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110055#
fast: false
name: thioredoxin reductase (NADPH)
is described by: ECO:0000269
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.8.1.9
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110055#_0c274510_68eb_4038_9765_38c973a08ae1
initial concentration: NaN
is encoded by: hsa:84649
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is: Q96PD7
initial amount: NaN
name: DGAT2
has only substance units: false

metaM CE2705 c
initial concentration: 1.0
is: CHEBI:52328
initial amount: NaN
type: Species
is: SBO:0000247
name: quinonoid dihydrobiopterin
constant: false
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
has only substance units: false

metaR PPCOAOm
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
reversible: false
reactant: MODEL1310110055#
fast: false
is described by: ECO:0000269
product: MODEL1310110055#
is: SBO:0000176
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
kinetic law: MODEL1310110055#

metaR EX oagt3 hs LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-O-Acetylated GT3 (homo sapiens) exchange
type: Reaction

metaM pmtcrn r
is: HMDB00222
is: CHEBI:17490
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: SBO:0000247
name: L-palmitoylcarnitine
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_589f911e_5353_4251_879f_1c657f9623cb
is encoded by: hsa:9517
is: O15270
boundary condition: true
name: SPTLC2
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252

metaR RE1845C
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110055#
name: RE1845
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
type: Reaction

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaR FAOXC123C102x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_e77f4f99_35fc_4514_8517_e226c1778dab
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5298
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: Q9UBF8
constant: false
name: PI4KB

metaM no e
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
name: Nitric oxide
is: HMDB03378
boundary condition: false
is: C00533
constant: false
is: CHEBI:16480

http://identifiers.org/biomodels.db/MODEL1310110055#_c5e6e0d1_3e1f_4813_9566_fe6982983c7c
initial amount: NaN
is encoded by: hsa:8867
is: SBO:0000252
constant: false
name: SYNJ1
has only substance units: false
is: C9JFZ1
initial concentration: NaN
type: Species
boundary condition: true

metaR COt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
is described by: ECO:0000000
name: CO transporter via diffusion
kinetic law: MODEL1310110055#
product: MODEL1310110055#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110055#

metaM ksii core2 pre3 g
has only substance units: false
type: Species
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 3
boundary condition: false
notes: FORMULA: C47H76N4O33X CHARGE: -1
is: SBO:0000247
is: C00130
initial concentration: 1.0
constant: false
is: CHEBI:58053
initial amount: NaN

metaM octa e
initial amount: NaN
type: Species
constant: false
is: CHEBI:25646
notes: FORMULA: C8H15O2 CHARGE: -1
has only substance units: false
is: HMDB00482
is: C06423
boundary condition: false
is: SBO:0000247
name: octanoate (n-C8:0)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_704b4f4e_46bf_48d0_8a33_6f103c149e2f
name: NDUFB5
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:4711
constant: false
is: O43674

http://identifiers.org/biomodels.db/MODEL1310110055#_da9cefbd_4f92_4b47_b279_1a7e14597e43
constant: false
has only substance units: false
is: Q969K7
name: TMEM54
initial concentration: NaN
type: Species
is encoded by: hsa:113452
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaM dha e
type: Species
constant: false
name: glycerone
has only substance units: false
is: CHEBI:16016
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB01882
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_085cd3c1_317d_430f_9e1e_b357d1130ff5
name: _AA502753_1_m
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:AA502753
initial amount: NaN
constant: false
initial concentration: NaN

metaR TAUPAT1c
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by PAT1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_98e176cd_81b5_4dc3_9438_73d98f15c080
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: O14521
name: SDHD
type: Species
is encoded by: hsa:6392
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_02f422f4_0722_4489_8ea5_f1e3e80dc668
type: Species
is encoded by: hsa:9435
constant: false
initial amount: NaN
initial concentration: NaN
is: Q9Y4C5
has only substance units: false
is: SBO:0000252
boundary condition: true
name: CHST2

http://identifiers.org/biomodels.db/MODEL1310110055#_1e707aa1_68be_4497_8a41_df872650ce6f
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
is: P13686
type: Species
is encoded by: hsa:54
initial amount: NaN
name: ACP5

http://identifiers.org/biomodels.db/MODEL1310110055#_b4106144_55bf_439b_a38e_cc84fec09a53
is: SBO:0000252
is: E7EPA7
type: Species
name: TKT
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:7086
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_6fd98429_2398_412c_9ca5_160bef5952d9
name: UPP1
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:7378
initial amount: NaN

metaR DTTPtn
type: Reaction
reactant: MODEL1310110055#
fast: false
is described by: ECO:0000000
name: dTTP diffusion in nucleus
is: SBO:0000185
kinetic law: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_dbcf14b7_195c_4d11_9e7d_d70c8fe228ce
initial concentration: NaN
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: INPP4A
boundary condition: true
is: Q96PE3
is encoded by: hsa:3631

http://identifiers.org/biomodels.db/MODEL1310110055#_4819a5d8_f7b6_40e3_91f1_0959bebc5d5f
name: NT5C
type: Species
is encoded by: hsa:30833
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q8TCD5
initial amount: NaN
boundary condition: true

metaR NDPK10
reversible: true
name: nucleoside-diphosphate kinase (ATP:dIDP)
is: SBO:0000176
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
kinetic law: MODEL1310110055#
is described by: ECO:0000134
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
modifier: MODEL1310110055#
type: Reaction

metaM vacccoa m
has only substance units: false
is: HMDB06521
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
name: vaccenyl coenzyme A
is: http://identifiers.org/pubchem.compound/9543677
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_f4c63730_37eb_4377_b526_2d074d843a7a
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:4537
name: ND3
initial amount: NaN
is: P03897
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_74625079_81a1_4a11_a3a5_e6f9a106ccd6
initial concentration: NaN
is: Q96C36
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: PYCR2
has only substance units: false
is encoded by: hsa:29920
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_d590d958_2a10_4bfb_8d30_1be9c17153c3
constant: false
is: SBO:0000252
is encoded by: hsa:3938
name: LCT
is: P09848
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species

metaM cs a deg4 l
is: SBO:0000247
is: CHEBI:57455
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB01354
initial amount: NaN
notes: FORMULA: C31H49NO29S CHARGE: -2
constant: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4

metaR RETI2
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
name: retinol isomerase (9-cis)
product: MODEL1310110055#
fast: false
reversible: true
is described by: ECO:0000000

metaR DNDPt10m
is: SBO:0000185
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
reversible: false
type: Reaction
name: dADP transport via dCDP antiport
fast: false
modifier: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110055#_f970e13f_8816_47af_8be0_9b9c87b30153
name: PIGP
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:51227
constant: false
boundary condition: true
type: Species

metaR FAOXC122x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)x
type: Reaction

metaR B3GNT312g
reactant: MODEL1310110055#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is: SBO:0000176
fast: false
reversible: false
kinetic law: MODEL1310110055#
is described by: ECO:0000254
product: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
modifier: MODEL1310110055#

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_31bc6567_ec39_4cd9_939d_ad230680aebe
has only substance units: false
initial amount: NaN
is encoded by: hsa:1375
initial concentration: NaN
boundary condition: true
is: B7Z5T8
type: Species
name: CPT1B
constant: false
is: SBO:0000252

metaR KHK
reversible: false
type: Reaction
reactant: MODEL1310110055#
fast: false
is described by: ECO:0000000
name: ketohexokinase
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.1.3
modifier: MODEL1310110055#
is: SBO:0000176
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110055#_37e2e394_b985_47df_a69b_1eb4e94ecd90
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q9NY65
is encoded by: hsa:1962
is: SBO:0000252
name: EHHADH
has only substance units: false
constant: false

metaR r0549
is version of: http://identifiers.org/ec-code/1.6.99.3
type: Reaction
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/6.1.1.17
is version of: http://identifiers.org/ec-code/1.6.5.3
reversible: true
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
reactant: MODEL1310110055#
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaR r2331
product: MODEL1310110055#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reversible: true
is: SBO:0000185

metaM HC00342 m
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:16383
has only substance units: false
type: Species
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
boundary condition: false
name: cis-aconitate(3-)

http://identifiers.org/biomodels.db/MODEL1310110055#_d5e3753f_0270_43ea_b419_1de52678f007
is encoded by: hsa:11181
initial concentration: NaN
is: SBO:0000252
name: TREH
boundary condition: true
initial amount: NaN
is: O43280
has only substance units: false
type: Species
constant: false

metaR ASCBt
kinetic law: MODEL1310110055#
is: SBO:0000185
reactant: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
reversible: true
type: Reaction
fast: false
name: L-ascorbate transport via facilitated diffusion

metaM glcur c
has only substance units: false
constant: false
is: HMDB00127
name: D-glucuronate
is: SBO:0000247
initial amount: NaN
is: CHEBI:15748
type: Species
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial concentration: 1.0
boundary condition: false

metaM dsT antigen g
is: HMDB01440
name: disialyl-T antigen
boundary condition: false
is: CHEBI:16497
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C36H56N3O26X CHARGE: -2
initial concentration: 1.0

metaM c8crn e
constant: false
has only substance units: false
is: C02838
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C15H29NO4 CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: HMDB00791
name: octanoyl carnitine

metaM lnlncgcoa r
is: CHEBI:57363
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: SBO:0000247
initial amount: NaN
is: HMDB06368
boundary condition: false
name: gamma-linolenoyl-CoA(4-)
constant: false
initial concentration: 1.0
type: Species
has only substance units: false

metaM cmpacna n
is: CHEBI:57812
initial amount: NaN
is: HMDB01176
constant: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
name: CMP-N-acetyl-beta-neuraminate(2-)
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM etfox m
boundary condition: false
initial amount: NaN
is: HMDB00145
is: CHEBI:17263
initial concentration: 1.0
name: Electron transfer flavoprotein oxidized
has only substance units: false
notes: FORMULA: R CHARGE: 0
is: SBO:0000247
type: Species
constant: false

metaM o2s c
name: superoxide
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: CHEBI:18421
constant: false
is: HMDB02168

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaR r0885
reversible: true
is: SBO:0000185
modifier: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.38
kinetic law: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
fast: false
reactant: MODEL1310110055#

metaR r0998
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110055#
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: true
name: Facilitated diffusion

metaR r2332
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110055#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
kinetic law: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#

metaR THBPT4ACAMDASE
is described by: ECO:0000269
reversible: false
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
is version of: http://identifiers.org/ec-code/4.2.1.96
product: MODEL1310110055#
fast: false
type: Reaction
reactant: MODEL1310110055#
modifier: MODEL1310110055#
is: SBO:0000176

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaM f1p c
name: D-Fructose 1-phosphate
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:18105
boundary condition: false
is: SBO:0000247
is: HMDB01076
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00662 EHMN_ABBREVIATION: C01094
is: C01094
has only substance units: false

metaR RTOTALFATPc
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

metaM accoa g
initial concentration: 1.0
is: HMDB01206
type: Species
name: acetyl-CoA(4-)
is: CHEBI:57288
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024

http://identifiers.org/biomodels.db/MODEL1310110055#_b5037634_6a26_47a4_b163_73b744c94e34
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
name: _83530_1_c
boundary condition: true
is encoded by: hsa:83530
initial concentration: NaN

metaM eipencoa x
constant: false
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
name: 2,5,8,11,14-eicosapentaenoylcoa
initial amount: NaN
has only substance units: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_0bd6e67d_ff55_4acd_85e7_e652c52a3751
initial amount: NaN
is encoded by: hsa:159963
is: SBO:0000252
boundary condition: true
constant: false
is: Q1EHB4
type: Species
initial concentration: NaN
has only substance units: false
name: SLC5A12

metaM 4mop m
boundary condition: false
is: CHEBI:17865
initial concentration: 1.0
name: 4-methyl-2-oxopentanoate
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
has only substance units: false
is: HMDB00695
initial amount: NaN

metaM pmtcrn m
type: Species
name: L-palmitoylcarnitine
constant: false
is: SBO:0000247
is: CHEBI:17490
has only substance units: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: HMDB00222
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

metaR GTHO
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
fast: false
modifier: MODEL1310110055#
is: SBO:0000176
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
reversible: false
type: Reaction
name: glutathione oxidoreductase
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.8.1.7
product: MODEL1310110055#

metaR r0995
is: SBO:0000185
reactant: MODEL1310110055#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: true
kinetic law: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
fast: false

metaM sph1p c
is: HMDB01383
initial concentration: 1.0
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
type: Species
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:57939
is: SBO:0000247
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate

http://identifiers.org/biomodels.db/MODEL1310110055#_cb1e8840_0cf7_4475_b675_2e95eecb88d1
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:9963
initial concentration: NaN
name: SLC23A1
is: Q9UHI7
boundary condition: true
type: Species
constant: false

metaR GLUPRT
is described by: ECO:0000269
kinetic law: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.14
name: glutamine phosphoribosyldiphosphate amidotransferase
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
product: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000176
reversible: false
type: Reaction

metaM c8crn c
is: HMDB00791
constant: false
type: Species
notes: FORMULA: C15H29NO4 CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: C02838
is: SBO:0000247
name: octanoyl carnitine
initial amount: NaN
has only substance units: false

metaR GTHP
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.11.1.9
is version of: http://identifiers.org/ec-code/1.11.1.12
reversible: true
is: SBO:0000176
reactant: MODEL1310110055#
fast: false
modifier: MODEL1310110055#
type: Reaction
name: glutathione peroxidase
is version of: http://identifiers.org/ec-code/1.11.1.15
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_8f2b7ef9_dd12_41fd_bd82_769b22e7a37f
is: B4DG68
name: NOS1
boundary condition: true
is encoded by: hsa:4842
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_01bd2e86_cc1b_46e0_acd2_84086ba46e39
name: C1GALT1
type: Species
is: Q9NS00
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:56913
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_5860f159_a422_4b57_8fa8_4b68d3aa4e67
type: Species
name: TPH2
boundary condition: true
is encoded by: hsa:121278
is: Q8IWU9
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaM o2s e
constant: false
is: HMDB02168
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:18421
name: superoxide
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false
has only substance units: false

metaR LPASE
type: Reaction
product: MODEL1310110055#
name: lysophospholipase
modifier: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5321.1) or (1178.1) or (29124.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9430701 NOTES:phosphatidyl choline degradation NJ
kinetic law: MODEL1310110055#
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.1.1.5

http://identifiers.org/biomodels.db/MODEL1310110055#_d0760d8d_fd96_4923_8779_4607891ac3b9
initial amount: NaN
initial concentration: NaN
is: SBO:0000297
name: IDH3A:IDH3B:IDH3G
is encoded by: hsa:3420
type: Species
constant: false
boundary condition: true
has only substance units: false

metaR r2443
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
kinetic law: MODEL1310110055#
is: SBO:0000185
reactant: MODEL1310110055#
fast: false
product: MODEL1310110055#
reversible: false
is described by: ECO:0000000

metaR r2330
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110055#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110055#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM HC02203 c
has only substance units: false
is: CHEBI:27820
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
name: prostaglandin-a2

http://identifiers.org/biomodels.db/MODEL1310110055#_f2bf2354_f888_44a2_9ac1_c09944c74b12
initial concentration: NaN
has part: E7EX19
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: PIK3CD:PIK3R1
boundary condition: true
is: SBO:0000297
is encoded by: hsa:5295

metaM ksii core2 deg3 l
type: Species
is: HMDB00143
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
name: keratan sulfate II (core 2-linked), degradation product 3
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:12936
initial amount: NaN
has only substance units: false

metaM accoa m
is: SBO:0000247
initial amount: NaN
name: Acetyl-CoA
is: CHEBI:57288
type: Species
is: HMDB01206
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial concentration: 1.0
has only substance units: false
is: C00024
constant: false
boundary condition: false

metaM C04849 e
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
is: CHEBI:57449
has only substance units: false
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM 5aop m
is: SBO:0000247
boundary condition: false
constant: false
is: C00430
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01149
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: CHEBI:17549
name: 5-Amino-4-oxopentanoate

metaM Rtotal3 e
initial concentration: 1.0
type: Species
name: R total 3 position
has only substance units: false
is: HMDB00244
is: SBO:0000247
notes: FORMULA: CO2FULLR3 CHARGE: -1
boundary condition: false
is: C00255
initial amount: NaN
constant: false
is: CHEBI:3554

metaR EX ddece1crn
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dodecenoyl carnitine
type: Reaction

metaR H2MTer L
is: SBO:0000176
product: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
type: Reaction
is described by: ECO:0000000
name: H2 mannosyltransferase, endoplasmic reticulum
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_84e8d13a_c3b6_4b27_8a41_6be4c6e69507
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:123041
initial concentration: NaN
constant: false
boundary condition: true
type: Species
name: SLC24A4

metaR GLYCLTDy
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:1252411,PMID:15240345,PMID:2689175 NOTES:JLR
type: Reaction
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.1.1.79
fast: false
kinetic law: MODEL1310110055#
is described by: ECO:0000269
modifier: MODEL1310110055#
name: Glycolate dehydrogenase (NADP)
reversible: false
reactant: MODEL1310110055#
is: SBO:0000176

metaM tetdec2coa c
has only substance units: false
constant: false
name: tetradecadienoylcoa
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
boundary condition: false
type: Species
is: HMDB02014
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_d962a6aa_90c7_44e9_a619_d372814d6155
is: SBO:0000252
is encoded by: hsa:221
constant: false
initial concentration: NaN
has only substance units: false
name: ALDH3B1
type: Species
initial amount: NaN
is: P43353
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_fa9afeae_dd5d_4ce5_8716_39ef27c75506
type: Species
name: _AL525798_1_c
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:AL525798
boundary condition: true

metaM spc hs c
name: sphingosylphosphorylcholine
boundary condition: false
is: http://identifiers.org/pubchem.compound/5311445
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN

metaR TRIODTHYt2
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000185
reversible: true
modifier: MODEL1310110055#
name: T3 transport via facilitated diffusion
fast: false
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
product: MODEL1310110055#

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_4febc056_b588_478d_8cc0_c3ea63fa3d32
is encoded by: hsa:AI024818
initial amount: NaN
type: Species
boundary condition: true
name: _AI024818_1_c
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM g2m8mpdol L r
constant: false
is: C05870
initial concentration: 1.0
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species
is: SBO:0000247
notes: FORMULA: C1900H3128N20O720P20 CHARGE: -20
boundary condition: false
initial amount: NaN
has only substance units: false

metaM accoa n
is: HMDB01206
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57288
type: Species
name: acetyl-CoA(4-)

metaM e4p c
is: C00279
constant: false
is: HMDB01321
type: Species
initial amount: NaN
boundary condition: false
name: D-Erythrose 4-phosphate
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
is: CHEBI:16897

metaM gln L c
has only substance units: false
is: CHEBI:18050
constant: false
type: Species
name: L-glutamine
initial amount: NaN
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00641

metaR S6T7g
kinetic law: MODEL1310110055#
type: Reaction
product: MODEL1310110055#
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
reactant: MODEL1310110055#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
is: SBO:0000176
fast: false

metaM arachcrn c
initial amount: NaN
initial concentration: 1.0
is: HMDB06460
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
name: arachidyl carnitine
is: SBO:0000247
type: Species
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_8fce4492_ca73_40ef_b34e_38d0debaebdf
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3098
boundary condition: true
type: Species
initial amount: NaN
is: P19367
name: HK1
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_metaM_galacglc13galacglcgal14acglcgalgluside_hs_g
is: CHEBI:26174
boundary condition: false
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
name: nLc8Cer

metaR FAOXC18280m
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
type: Reaction
modifier: MODEL1310110055#
name: Beta oxidation of fatty acid
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:2, transe -> c8:0 - 5 rounds of beta ox, lose 2 degrees of unsat - only 3 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaR PPBNGS
is version of: http://identifiers.org/ec-code/4.2.1.24
name: porphobilinogen synthase
fast: false
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
is: SBO:0000176
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (210.1) or (210.2) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.24 Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110055#_c7749ae5_229b_4c92_a49f_aa5dce7d7350
is: Q4G1C4
name: ZADH2
type: Species
is encoded by: hsa:284273
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

metaR r1649
modifier: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true

metaR MMSAD3m
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000269
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
reversible: false
modifier: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.27

http://identifiers.org/biomodels.db/MODEL1310110055#_19dc1312_788a_4f36_bfdc_57ebbf0a768f
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: Q67FW5
name: B3GNTL1
is encoded by: hsa:146712

metaR r0999
reversible: true
fast: false
reactant: MODEL1310110055#
product: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Facilitated diffusion

http://identifiers.org/biomodels.db/MODEL1310110055#_aa41f04e_0271_48f5_9fbd_12373cd109b8
initial concentration: NaN
is: Q5T4W8
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:6487
name: ST3GAL3
constant: false

metaR CYSGLNNaEx
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110055#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-cysteine/L-glutamine Na-dependent exchange (Cys-L in)

http://identifiers.org/biomodels.db/MODEL1310110055#_475da1ea_a9df_46c2_870d_3ed71feb913f
type: Species
constant: false
is encoded by: hsa:509
has only substance units: false
has part: Q6I9V2
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
has part: P25705
is: SBO:0000297
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:498

http://identifiers.org/biomodels.db/MODEL1310110055#_fe6de821_ac9b_4bd8_ab62_486dd29d6137
is encoded by: hsa:6582
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
name: SLC22A2
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_c06959b7_8d0a_4990_a413_6a7e7e0f0e80
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:AI934540
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: _AI934540_1_c

http://identifiers.org/biomodels.db/MODEL1310110055#_bc65207d_2b2e_404f_a975_8ac8ced125cc
initial amount: NaN
name: _W74642_1_c
constant: false
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:W74642

metaR FAOXC141C121x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C14:1-->C12:1)x
type: Reaction

metaM pail5p hs n
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
type: Species
constant: false
initial amount: NaN
is: CHEBI:57795

metaM spc hs e
name: sphingosylphosphorylcholine
boundary condition: false
is: http://identifiers.org/pubchem.compound/5311445
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_3b9f4d1c_034b_47f5_af55_a7eec158b148
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:AA278423
name: _AA278423_1_m
is: SBO:0000252
has only substance units: false
constant: false
type: Species

metaR G12MT2 L
fast: false
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
reversible: false
type: Reaction
reactant: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_fbdc8cab_1df1_4510_b165_47baaec53d87
has only substance units: false
name: _BE966236_1_m
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:BE966236
is: SBO:0000252

metaM glcur e
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00127
is: CHEBI:15748
initial amount: NaN
name: D-glucuronate
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_046520b0_5989_4dd9_9352_d613fada7245
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: DPYSL2
is encoded by: hsa:1808
boundary condition: true
is: B4DR31
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_d2ce3cb5_a34e_4869_9486_86e9a3d8ccd3
is: Q9NNW7
boundary condition: true
is: SBO:0000252
name: TXNRD2
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:10587
constant: false
initial concentration: NaN

metaM gln L e
is: CHEBI:18050
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
name: L-glutamine
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
boundary condition: false
is: HMDB00641

metaR r1648
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
product: MODEL1310110055#
modifier: MODEL1310110055#
is: SBO:0000185
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM acgam l
is: HMDB00215
has only substance units: false
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: CHEBI:17411
is: SBO:0000247
type: Species
constant: false
name: N-acetyl-D-glucosamine
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_58b299a0_13c7_4999_89bd_e1eb77540311
boundary condition: true
is: SBO:0000252
name: PIGU
has only substance units: false
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: Q9H490
is encoded by: hsa:128869

metaR FAOXC101C8m
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_744e1fc7_d8b2_4740_99cb_2799bf35c3ae
is: SBO:0000252
has only substance units: false
name: GBA
is: B7Z5G2
is encoded by: hsa:2629
initial concentration: NaN
boundary condition: true
constant: false
type: Species
initial amount: NaN

metaR DGULND
fast: false
reactant: MODEL1310110055#
name: dehydro-L-gulonate decarboxylase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
reversible: true
kinetic law: MODEL1310110055#
type: Reaction
is: SBO:0000176
product: MODEL1310110055#
is described by: ECO:0000000

metaR r1647
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110055#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110055#
fast: false
reversible: true
kinetic law: MODEL1310110055#

metaM cl c
is: C00115
is: HMDB00492
initial amount: NaN
is: SBO:0000247
type: Species
name: Chloride
is: CHEBI:3966
notes: FORMULA: Cl CHARGE: -1
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_037d5158_65b2_47ee_8e11_b816fd8675be
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
name: SLC4A5
is encoded by: hsa:57835

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaR SERGLNexR
type: Reaction
product: MODEL1310110055#
name: L-Serine/Glutamine reversible exchange
modifier: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110055#
is described by: ECO:0000304
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_c9bdad76_29f1_42c4_9705_a3a6bfa7db6f
name: SUCLG1:SUCLA2
is encoded by: hsa:8803
initial concentration: NaN
has part: E5KS60
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000297
boundary condition: true
constant: false

metaR r0541
kinetic law: MODEL1310110055#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
modifier: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
is: SBO:0000176
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7

metaM homoval m
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
name: Homovanillate
is: CHEBI:545959
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
is: HMDB00118
has only substance units: false
initial amount: NaN

metaM HC02187 e
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
name: reverse-triiodthyronine
initial concentration: 1.0
is: CHEBI:28774
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_ccbe821b_1e49_45d9_9277_185a08d1f875
name: PANK2
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q6P1K9
type: Species
is encoded by: hsa:80025
boundary condition: true

metaR DMHPTCRNte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:unknown mechanism for transport -see PMID 9299016, identifies 2,6-dimethylheptanoyl carnitine in the urine! NJ
product: MODEL1310110055#
reversible: true
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000000
name: 2,6 dimethylheptanoyl carnitine transport
is: SBO:0000185
type: Reaction
fast: false

metaR BPNT
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
is: SBO:0000176
reversible: false
fast: false
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.1.3.7
type: Reaction
kinetic law: MODEL1310110055#
product: MODEL1310110055#
name: 3',5'-bisphosphate nucleotidase
reactant: MODEL1310110055#

metaM acgam r
name: N-acetyl-D-glucosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: CHEBI:17411
has only substance units: false
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00215
initial amount: NaN
boundary condition: false

metaR PSYGCHe
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of psyllium with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_d36e4fc3_bc80_4e5a_a550_5642a8bfeccf
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
name: NAE1
type: Species
has only substance units: false
is encoded by: hsa:8883
initial concentration: NaN
is: A8MU28

metaM doco13ac e
name: docosenoic acid (C22:1)
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB02068
notes: FORMULA: C22H41O2 CHARGE: -1
is: SBO:0000247
has only substance units: false
type: Species
constant: false

metaM 2oxoadp c
type: Species
is: HMDB00225
initial amount: NaN
name: 2-oxoadipate(2-)
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:57499
is: SBO:0000247

metaM fald c
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:16842
name: formaldehyde
type: Species
has only substance units: false
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
initial amount: NaN
is: HMDB01426
is: SBO:0000247

metaR r1646
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110055#
type: Reaction
fast: false
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110055#

metaM accoa r
is: HMDB01206
name: acetyl-CoA(4-)
initial amount: NaN
has only substance units: false
is: CHEBI:57288
is: SBO:0000247
type: Species
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
boundary condition: false
initial concentration: 1.0
constant: false

metaM ptdcacoa m
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB06499
type: Species
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
name: pentadecanoyl Coenzyme A

metaR r0990
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
name: Postulated transport reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110055#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:

metaM ibcoa m
name: isobutyryl-CoA(4-)
is: CHEBI:57338
type: Species
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB01243

metaM datp n
name: dATP
constant: false
is: C00131
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
boundary condition: false
initial concentration: 1.0
is: CHEBI:61404
type: Species
is: HMDB01532

metaM HC00342 c
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
is: SBO:0000247
type: Species
initial concentration: 1.0
name: cis-aconitate(3-)
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:16383
has only substance units: false

metaR FAOXC164C165x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)x
type: Reaction

metaR r1645
product: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: true
modifier: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110055#
is: SBO:0000185
is described by: ECO:0000000

metaR RE0453C
product: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
is: SBO:0000176
name: RE0453
fast: false
kinetic law: MODEL1310110055#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:

metaM 5fthf m
is: HMDB01562
initial concentration: 1.0
constant: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
name: 5-formyltetrahydrofolate(2-)
is: SBO:0000247
is: CHEBI:57457
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_b6b6d74b_6fbd_467f_a84d_2ddc63dc5873
boundary condition: true
is: SBO:0000252
name: _AF116616_1_m
is encoded by: hsa:AF116616
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_d370867a_48fc_4558_99d8_ff2e64d8c8ca
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaR B3GNT34g
is: SBO:0000176
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
kinetic law: MODEL1310110055#
is described by: ECO:0000269
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110055#
product: MODEL1310110055#
fast: false
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110055#_08114bd2_b130_4750_801d_2031d089d158
name: ADCY5
initial amount: NaN
is: O95622
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:111
has only substance units: false

metaR RE2625C
fast: false
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
is described by: ECO:0000000
type: Reaction
reversible: true
name: RE2625
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:

metaR G14T3g
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
modifier: MODEL1310110055#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is described by: ECO:0000000
product: MODEL1310110055#

metaM sphs1p c
type: Species
constant: false
name: sphingosine 1-phosphate(1-)
has only substance units: false
initial amount: NaN
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: HMDB00277
initial concentration: 1.0
is: CHEBI:60119
is: SBO:0000247
boundary condition: false

metaM abt c
is: CHEBI:18403
constant: false
is: HMDB01851
type: Species
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: L-arabinitol

metaM acnamp c
initial amount: NaN
is: HMDB06268
name: N-Acetylneuraminate 9-phosphate
has only substance units: false
constant: false
type: Species
boundary condition: false
is: CHEBI:27438
initial concentration: 1.0
notes: FORMULA: C11H17NO12P CHARGE: -3 INCHI: InChI=1S/C11H20NO12P/c1-4(13)12-7-5(14)2-11(19,10(17)18)24-9(7)8(16)6(15)3-23-25(20,21)22/h5-9,14-16,19H,2-3H2,1H3,(H,12,13)(H,17,18)(H2,20,21,22)/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01734 EHMN_ABBREVIATION: C06241
is: SBO:0000247

metaR r1644
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110055#
is: SBO:0000185
reversible: true
modifier: MODEL1310110055#
type: Reaction
product: MODEL1310110055#
kinetic law: MODEL1310110055#

metaM 4mzym int2 r
is: SBO:0000247
name: 4-Methylzymosterol intermediate 2
initial amount: NaN
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
boundary condition: false
type: Species
is: HMDB06838
has only substance units: false
constant: false
initial concentration: 1.0

metaR TPI
is version of: http://identifiers.org/ec-code/5.3.1.1
reversible: true
reactant: MODEL1310110055#
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
name: triose-phosphate isomerase
is described by: ECO:0000134
product: MODEL1310110055#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
is: SBO:0000176

metaR FAOXC2051843m
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
reversible: false
modifier: MODEL1310110055#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000

metaR r2338
is: SBO:0000185
reversible: true
product: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
reactant: MODEL1310110055#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:

metaR S3TASE3ly
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000000
kinetic law: MODEL1310110055#
reversible: true
type: Reaction
fast: false
name: N-acetylglucosamine-3-sulfatase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is: SBO:0000176

metaM CE4876 r
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: delta12-Prostaglandin J2
boundary condition: false
is: CHEBI:57923
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876

metaM pail4p hs n
is: CHEBI:58178
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
boundary condition: false
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
constant: false

metaR r1643
kinetic law: MODEL1310110055#
product: MODEL1310110055#
modifier: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110055#
is: SBO:0000185
is described by: ECO:0000000

metaR ABO9g
is: SBO:0000176
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.4.1.37
fast: false
reversible: false
reactant: MODEL1310110055#
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#

metaR C10CRNe
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decanoyl carnitine into extra cellular space
type: Reaction

metaR r0545
kinetic law: MODEL1310110055#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110055#
fast: false
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
product: MODEL1310110055#
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_48600634_78f0_4cc2_9c78_7f1aa35184e8
has only substance units: false
is encoded by: hsa:AI378339
name: _AI378339_1_m
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_dcb2a4e6_9efd_4828_914f_5ee1620839ad
name: ALPPL2
is encoded by: hsa:251
boundary condition: true
initial concentration: NaN
is: P10696
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
has only substance units: false

metaM pmtcrn c
is: SBO:0000247
initial amount: NaN
name: L-palmitoylcarnitine
boundary condition: false
is: HMDB00222
constant: false
type: Species
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
has only substance units: false
initial concentration: 1.0
is: CHEBI:17490

metaM arachcrn m
name: arachidyl carnitine
type: Species
constant: false
is: HMDB06460
is: SBO:0000247
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_d866f5a3_075c_4537_a79d_c507c8293ffb
is encoded by: hsa:55753
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q9ULD0
type: Species
name: OGDHL
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_e0be971a_b767_48b3_afa7_85191cc690d5
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:498
is: B4DY56
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
name: ATP5A1

http://identifiers.org/biomodels.db/MODEL1310110055#_4693a197_daba_409a_a91f_d32cb0b778f4
is: Q3I5F7
is encoded by: hsa:641372
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
name: ACOT6
type: Species
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_84ae51ce_45a0_4770_914c_4811548883b7
is encoded by: hsa:124583
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
name: CANT1
constant: false
is: Q8WVQ1
initial amount: NaN

metaR r0276
reactant: MODEL1310110055#
fast: false
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.21
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
modifier: MODEL1310110055#
is: SBO:0000176
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.1.1.2
kinetic law: MODEL1310110055#
is described by: ECO:0000000
reversible: true

metaR r0994
is: SBO:0000185
kinetic law: MODEL1310110055#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110055#
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
product: MODEL1310110055#

metaR r1642
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110055#
product: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110055#_e5a305aa_edb2_4626_82ad_63e1c84f8728
has only substance units: false
boundary condition: true
name: OGDH
initial concentration: NaN
type: Species
is encoded by: hsa:4967
is: SBO:0000252
constant: false
is: Q02218
initial amount: NaN

metaM HC02203 e
type: Species
is: SBO:0000247
boundary condition: false
name: prostaglandin-a2
initial amount: NaN
constant: false
is: CHEBI:27820
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953

http://identifiers.org/biomodels.db/MODEL1310110055#_8440f311_701a_499a_ae44_490c1e6bad92
is encoded by: hsa:1719
initial amount: NaN
has only substance units: false
is: P00374
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: DHFR
constant: false
type: Species

metaM abt e
name: L-arabinitol
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: SBO:0000247
is: CHEBI:18403
has only substance units: false
constant: false
type: Species
is: HMDB01851
boundary condition: false
initial concentration: 1.0

metaR FAOXC201C181x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

metaM 5aop c
initial concentration: 1.0
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
has only substance units: false
constant: false
is: CHEBI:17549
is: SBO:0000247
is: HMDB01149
is: C00430
initial amount: NaN
type: Species
name: 5-Amino-4-oxopentanoate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_e0258f7a_5113_4f54_bd8e_58b4f6f091d1
boundary condition: true
constant: false
is encoded by: hsa:4598
is: SBO:0000252
is: B2RDU6
type: Species
has only substance units: false
name: MVK
initial amount: NaN
initial concentration: NaN

metaM datp m
is: C00131
is: HMDB01532
initial amount: NaN
boundary condition: false
type: Species
name: dATP
initial concentration: 1.0
is: CHEBI:61404
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131

http://identifiers.org/biomodels.db/MODEL1310110055#_1fcc2ab5_3be1_4786_9508_f6a37082491d
boundary condition: true
initial amount: NaN
name: DPM3:DPM1:DPM2
is encoded by: hsa:54344
constant: false
type: Species
has part: O60762
is: SBO:0000297
initial concentration: NaN
has part: O94777
has only substance units: false
is encoded by: hsa:8813
is encoded by: hsa:8818
has part: Q86TM7

metaM sph1p e
is: SBO:0000247
boundary condition: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
type: Species
has only substance units: false
is: HMDB01383
initial concentration: 1.0
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
constant: false
initial amount: NaN
is: CHEBI:57939

metaR B3GALT5g
product: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
name: Beta-1,3-galactosyltransferase 5
reversible: false
is: SBO:0000176
modifier: MODEL1310110055#

metaR r0780
product: MODEL1310110055#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
kinetic law: MODEL1310110055#
reversible: true
reactant: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
fast: false
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_15c86f49_1117_411c_99f3_ebba05d81fba
name: ACAD8
is encoded by: hsa:27034
boundary condition: true
type: Species
is: SBO:0000252
is: Q6ZWP6
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_490ed3a8_ee9f_463c_a4cb_749ed264b1ab
constant: false
has only substance units: false
name: NDUFA9
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4704
is: Q16795

metaR DOPAt4 2 r
is: SBO:0000185
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
product: MODEL1310110055#
reactant: MODEL1310110055#
modifier: MODEL1310110055#
name: Dopamine reversible transport in via sodium symport (1:2)
fast: false
kinetic law: MODEL1310110055#
is described by: ECO:0000269
reversible: true

metaR r2333
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110055#
is: SBO:0000185
reactant: MODEL1310110055#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
product: MODEL1310110055#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_9e767273_053e_490b_a238_9e962232b703
has only substance units: false
is: P05091
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:217
constant: false
boundary condition: true
type: Species
is: SBO:0000252
name: ALDH2

metaM cl e
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: C00115
is: SBO:0000247
is: CHEBI:3966
notes: FORMULA: Cl CHARGE: -1
name: Chloride
constant: false
is: HMDB00492
has only substance units: false

metaR ACHtn
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
name: Acetylcholin transport, nuclear trhough pores
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reversible: true

metaM c10dc x
type: Species
constant: false
initial amount: NaN
name: sebacoyl carnitine
has only substance units: false
is: HMDB00651
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C17H30NO6 CHARGE: -1

metaR r1641
fast: false
is: SBO:0000185
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110055#
type: Reaction
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110055#

metaM HC01231 c
constant: false
is: CHEBI:58480
initial concentration: 1.0
name: N-[(R)-pantothenoyl]-L-cysteinate
type: Species
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR DGNSKm
reversible: false
reactant: MODEL1310110055#
name: deoxyguanosine kinase
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (1716.5) or (1716.1) or (1716.4) or (1716.2) or (1716.3) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:8692979 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.113
is: SBO:0000176

metaM icit x
initial concentration: 1.0
is: CHEBI:16087
boundary condition: false
name: isocitrate(3-)
is: HMDB00193
type: Species
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_126e6ce9_8867_425e_8d09_659595116627
initial concentration: NaN
constant: false
is: D9HTE9
name: SLC25A1
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6576
initial amount: NaN

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaR r2334
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110055#
is: SBO:0000185
reactant: MODEL1310110055#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110055#
is described by: ECO:0000000

metaM 2mp2coa m
boundary condition: false
is: CHEBI:27754
type: Species
is: HMDB01011
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
constant: false
initial amount: NaN
has only substance units: false
name: 2-Methylprop-2-enoyl-CoA
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_c7543e4d_6c75_4087_a00a_f67511a89291
constant: false
boundary condition: true
is: Q8TDB8
type: Species
name: SLC2A14
is: SBO:0000252
is encoded by: hsa:144195
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_fc5c3ae1_aee0_42e4_803a_052d8851f70f
name: _AA629629_1_m
type: Species
is encoded by: hsa:AA629629
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR PIt7
product: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
reactant: MODEL1310110055#
is described by: ECO:0000269
name: phosphate transport in/out via three Na+ symporter
is: SBO:0000185
fast: false
reversible: true
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#

metaR DNDPt25m
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000269
modifier: MODEL1310110055#
name: dTDP transport via dCDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
reactant: MODEL1310110055#

metaM 3pg m
initial concentration: 1.0
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: CHEBI:58272
is: SBO:0000247
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
has only substance units: false
is: HMDB00807

metaR PIt8
is described by: ECO:0000006
fast: false
reactant: MODEL1310110055#
name: phosphate transport in/out via Na+ symporter
type: Reaction
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
product: MODEL1310110055#
modifier: MODEL1310110055#
reversible: true
kinetic law: MODEL1310110055#
is: SBO:0000185

metaR r1640
kinetic law: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110055#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110055#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_8db40d85_e252_4972_adcb_75af28591c7c
is encoded by: hsa:3550
type: Species
has only substance units: false
is: SBO:0000252
name: IK
initial concentration: NaN
constant: false
is: Q13123
initial amount: NaN
boundary condition: true

metaR r1650
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000185
modifier: MODEL1310110055#
fast: false
product: MODEL1310110055#

metaR ALAtN1
product: MODEL1310110055#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
modifier: MODEL1310110055#
fast: false
name: Alanine transport (Na, H coupled)
reversible: true

metaM s7p c
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
initial concentration: 1.0
is: HMDB01068
name: Sedoheptulose 7-phosphate
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:57483
is: C05382

metaR SCPx
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
is described by: ECO:0000269
name: peroxisomal thiolase 2
product: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
type: Reaction
kinetic law: MODEL1310110055#
reversible: false
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.3.1.176
is: SBO:0000176

metaM ppcoa c
type: Species
name: Propanoyl-CoA
initial concentration: 1.0
is: C00100
is: SBO:0000247
is: HMDB01275
constant: false
is: CHEBI:57392
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100

http://identifiers.org/biomodels.db/MODEL1310110055#_ca7deee0_da71_41bc_810a_1c71d4af9036
boundary condition: true
is: B4DYG5
is: SBO:0000252
name: PI4KA
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:5297
initial concentration: NaN
type: Species

metaR COAtm
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reversible: true
modifier: MODEL1310110055#
name: CoA transporter
fast: false
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
product: MODEL1310110055#

metaM lgt S c
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
name: (R)-S-lactoylglutathionate(1-)
boundary condition: false
is: HMDB01066
initial amount: NaN
is: CHEBI:57474

http://identifiers.org/biomodels.db/MODEL1310110055#_121f5287_bb74_44ee_a4d9_7ea780542f3b
type: Species
is encoded by: hsa:8574
has only substance units: false
is: SBO:0000252
is: O43488
initial concentration: NaN
boundary condition: true
name: AKR7A2
constant: false
initial amount: NaN

metaR r1651
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110055#
fast: false
reversible: true
product: MODEL1310110055#
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_75c56701_e20b_443c_85f0_696bf640abb1
initial amount: NaN
name: _AV717590_1_c
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:AV717590
initial concentration: NaN
type: Species

metaR CYTK2n
kinetic law: MODEL1310110055#
fast: false
reversible: true
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP),nuclear
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110055#
product: MODEL1310110055#

metaR MACACI
product: MODEL1310110055#
modifier: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110055#
name: maleylacetoacetate isomerase
is: SBO:0000176
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.5.1.18
type: Reaction
reversible: false

metaR HACD1m
is version of: http://identifiers.org/ec-code/1.1.1.35
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
modifier: MODEL1310110055#
product: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110055#
reversible: true
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
is: SBO:0000176
type: Reaction
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_2264b7dd_c25a_40c2_a0be_7f189f0f2dfa
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
name: DYLX2
type: Species
is encoded by: hsa:9856
is: F5H123

http://identifiers.org/biomodels.db/MODEL1310110055#_ca19a2fd_6967_4fca_93e3_3599f72b91d0
name: SULT1A2
is encoded by: hsa:6799
constant: false
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaM prgnlone c
has only substance units: false
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953
initial concentration: 1.0
name: pregnenolone
initial amount: NaN
is: HMDB00253
boundary condition: false
constant: false
type: Species
is: CHEBI:16581
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_c0c53315_bf02_4a95_a07c_cb53eed85fce
initial amount: NaN
is: Q96QE2
type: Species
has only substance units: false
name: SLC2A13
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:114134
constant: false

metaM psyl e
name: psyllium
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB11178
notes: FORMULA: C9642006H15428700O8667414 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110055#_41094809_bd6b_41a0_9c2d_74cb4607b5ba
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:23539
is: O95907
has only substance units: false
constant: false
name: SLC16A8

metaM 3hdececrn c
notes: FORMULA: C23H43NO5 CHARGE: 0
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
is: HMDB02014
name: 3-hydroxyhexadecenoylcarnitine
initial amount: NaN
initial concentration: 1.0

metaM ptdcacoa c
name: pentadecanoyl Coenzyme A
constant: false
boundary condition: false
is: HMDB06499
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
has only substance units: false
is: SBO:0000247

metaR r1377
type: Reaction
is: SBO:0000176
product: MODEL1310110055#
is described by: ECO:0000000
kinetic law: MODEL1310110055#
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110055#
reversible: true

metaM glcur r
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
boundary condition: false
has only substance units: false
is: CHEBI:15748
constant: false
is: HMDB00127
initial amount: NaN
name: D-glucuronate
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR DOCO13EFATP
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: absorption or uptake of 13-docosenoic acid into cells
type: Reaction

metaR 34HPPte
name: Transport of 3-(4-hydroxyphenyl)pyruvate
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
is: SBO:0000185
product: MODEL1310110055#
reversible: true
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110055#_a62011bb_35cf_42d5_8de5_2d1e8e188bd9
type: Species
name: NT5E
is: P21589
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:4907
initial concentration: NaN
has only substance units: false
constant: false

metaR HEDCECRNe
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecenoyl carnitine into extra cellular space
type: Reaction

metaR 7DHCHSTEROLtr
reversible: true
name: cholesterol precursor intracellular transport
fast: false
product: MODEL1310110055#
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is described by: ECO:0000000
type: Reaction

metaR COAtn
fast: false
reactant: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110055#
is: SBO:0000185
name: coenzyme A transport, nuclear
is described by: ECO:0000000

metaR r1378
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110055#
reversible: true
fast: false
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_d14432be_3fad_4b3c_b49c_227d4b4afa14
constant: false
has only substance units: false
initial amount: NaN
name: _AI694761_1_c
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI694761
boundary condition: true
type: Species

metaM ksii core2 pre4 g
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C53H86N4O38X CHARGE: -1
is: SBO:0000247
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 4
constant: false
is: C00130
is: CHEBI:58053
has only substance units: false
boundary condition: false
type: Species

metaM lnlncgcoa c
is: HMDB06368
name: gamma-linolenoyl-CoA(4-)
constant: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57363

metaM accoa x
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: C00024
initial concentration: 1.0
is: CHEBI:57288
boundary condition: false
type: Species
initial amount: NaN
name: Acetyl-CoA
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB01206

metaM HC01104 e
is: SBO:0000247
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
type: Species
is: CHEBI:61146
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: 4-nitrophenyl phosphate(2-)
constant: false

metaM dcsptn1crn m
name: docosa-4,7,10,13,16-pentaenoyl carnitine
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
is: SBO:0000247
has only substance units: false
is: HMDB06321
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_b8d49805_2e4e_4be2_ae0e_667f0347b7fe
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: _AA081045_1_c
is encoded by: hsa:AA081045
boundary condition: true
initial amount: NaN
constant: false

metaM 3hdececrn e
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C23H43NO5 CHARGE: 0
has only substance units: false
initial amount: NaN
name: 3-hydroxyhexadecenoylcarnitine
boundary condition: false
is: HMDB02068
type: Species

metaR NRPPHRSFt
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
reactant: MODEL1310110055#
reversible: false
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110055#
kinetic law: MODEL1310110055#
name: norepinephrine sulfate transport (diffusion)

http://identifiers.org/biomodels.db/MODEL1310110055#_0b8c383b_11d3_462a_ac4f_7d1a91647d24
has only substance units: false
is encoded by: hsa:5335
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: PLCG1
initial amount: NaN
type: Species
is: Q9UFY1

metaR FAOXC204
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reactant: MODEL1310110055#
product: MODEL1310110055#
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is: SBO:0000176

metaR ALDD21
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (224.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:8528251 NOTES:NJ
is described by: ECO:0000304
type: Reaction
name: aldehyde dehydrogenase (pristanal, NAD)
reactant: MODEL1310110055#
fast: false
is: SBO:0000176
modifier: MODEL1310110055#

metaR EICOSTETCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110055#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110055#
product: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
name: carnitine O-palmitoyltransferase
reversible: false
is: SBO:0000176

metaR EX acmana LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-acetyl-D-mannosamine
type: Reaction

metaM dcsptn1coa m
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
boundary condition: false
is: HMDB06513
initial amount: NaN
constant: false
is: C16173
type: Species
is: http://identifiers.org/pubchem.compound/47205483
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
has only substance units: false

metaM sphs1p e
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: SBO:0000247
name: sphingosine 1-phosphate(1-)
is: CHEBI:60119
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00277

http://identifiers.org/biomodels.db/MODEL1310110055#_0acc83c0_a821_4316_9675_85ba699009a4
initial amount: NaN
name: MECR
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:51102
type: Species
is: Q9BV79
has only substance units: false
initial concentration: NaN

metaR INSt
product: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
is described by: ECO:0000269
is: SBO:0000185
reversible: true
name: Inosine transport (diffusion)
reactant: MODEL1310110055#
modifier: MODEL1310110055#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_8879306e_401e_43cf_9c60_b74549ca7cca
constant: false
initial amount: NaN
has only substance units: false
name: MTMR3
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:8897
is: Q13615

http://identifiers.org/biomodels.db/MODEL1310110055#_09007f06_f50d_42ad_9ac9_61dba54a1847
boundary condition: true
constant: false
is: Q02221
type: Species
initial concentration: NaN
name: COX6A2
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1339

metaM 4mop c
constant: false
initial concentration: 1.0
type: Species
name: 4-methyl-2-oxopentanoate
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:17865
is: HMDB00695
initial amount: NaN

metaR EICOSTETCPT2
is: SBO:0000176
name: carnitine transferase
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
type: Reaction
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000000
modifier: MODEL1310110055#
reactant: MODEL1310110055#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR RE2625M
name: RE2625
is: SBO:0000176
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
product: MODEL1310110055#

metaR B3GNT35g
reversible: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
kinetic law: MODEL1310110055#
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110055#
is described by: ECO:0000269
reactant: MODEL1310110055#

metaR SPODMx
kinetic law: MODEL1310110055#
name: superoxide dismutase, peroxisome
reversible: false
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
modifier: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/1.15.1.1
is described by: ECO:0000269
is: SBO:0000176
fast: false
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_a15f7973_51a5_4074_9e15_3980cfd0f6da
is: Q07326
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
name: PIGF
initial concentration: NaN
is encoded by: hsa:5281
initial amount: NaN
constant: false

metaR FAOXC5C5OHm
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C5OH)m
type: Reaction

metaM 5dhf e
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
has only substance units: false
name: pentaglutamyl folate (DHF)
type: Species
is: HMDB06487
constant: false

metaR HSPASEly
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: false
name: heparan sulfate proteoglycan protease, lysosome (endosome)
fast: false
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_6ae4af87_63cd_483c_817b_d0778b2a0338
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
name: ALDOC
boundary condition: true
is: P09972
is encoded by: hsa:230
has only substance units: false
is: SBO:0000252

metaM na1 x
initial concentration: 1.0
boundary condition: false
name: sodium(1+)
is: CHEBI:29101
type: Species
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
is: SBO:0000247
has only substance units: false
is: HMDB00588
constant: false
initial amount: NaN

metaM trdox c
is: C00343
has only substance units: false
name: Oxidized thioredoxin
is: CHEBI:18191
initial concentration: 1.0
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
type: Species

metaM prist c
name: pristanic acid
is: HMDB00795
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
is: CHEBI:51340
constant: false
initial concentration: 1.0
has only substance units: false

metaR SERALANaEx
modifier: MODEL1310110055#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
name: L-alanine/L-serine Na-dependent exchange (Ser-L in)
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110055#_77bdad3e_e84c_4452_80f3_b78563fe790b
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: QDPR
is: P09417
constant: false
is encoded by: hsa:5860
has only substance units: false
type: Species

metaR LNELDCCPT2
kinetic law: MODEL1310110055#
is described by: ECO:0000000
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110055#
name: carnitine transferase
modifier: MODEL1310110055#

metaR r0669
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
fast: false
is: SBO:0000176

metaR r0774
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110055#
product: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110055#_5c6b3eed_f669_43f1_929e_c2a040e5a6b4
type: Species
is: O95470
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: SGPL1
is encoded by: hsa:8879
has only substance units: false
constant: false

metaM ksi pre16 g
is: C00130
initial amount: NaN
constant: false
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
name: keratan sulfate I biosynthesis, precursor 16
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00175
is: CHEBI:58053
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_9fc03a74_f3a6_4909_b904_4cc71043ce69
type: Species
has only substance units: false
is encoded by: hsa:3291
is: P80365
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: HSD11B2
initial amount: NaN
constant: false

metaM HC02187 c
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
has only substance units: false
type: Species
initial concentration: 1.0
name: reverse-triiodthyronine
boundary condition: false
constant: false
is: CHEBI:28774
is: SBO:0000247
initial amount: NaN

metaR LNELDCCPT1
kinetic law: MODEL1310110055#
type: Reaction
is: SBO:0000176
reversible: false
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
product: MODEL1310110055#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110055#
name: carnitine O-palmitoyltransferase

metaR r2329
product: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110055#

metaR r0668
is version of: http://identifiers.org/ec-code/2.4.2.19
modifier: MODEL1310110055#
fast: false
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
is described by: ECO:0000000
kinetic law: MODEL1310110055#
type: Reaction
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
is: SBO:0000176
reactant: MODEL1310110055#
reversible: true

metaR SBCOAACOTx
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of suberyl coa for release into cytosol
type: Reaction

metaR LPS4e
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: false
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (50487.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10713052 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
is version of: http://identifiers.org/ec-code/3.1.1.4
name: phospholipase

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaM dgmp m
initial amount: NaN
is: SBO:0000247
is: C00362
type: Species
has only substance units: false
is: CHEBI:57673
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: HMDB01044
boundary condition: false
initial concentration: 1.0
constant: false
name: dGMP

http://identifiers.org/biomodels.db/MODEL1310110055#_52a09463_6d0a_476e_93f2_5b08d28d736e
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
has part: P51553
is encoded by: hsa:3420
name: IDH3A:IDH3B:IDH3G
is: SBO:0000297
is encoded by: hsa:3421
has part: O43837

metaR BAAT2x
kinetic law: MODEL1310110055#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.65
name: bile acid Coenzyme A: amino acid N-acyltransferase
reactant: MODEL1310110055#
fast: false
is: SBO:0000176
product: MODEL1310110055#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
modifier: MODEL1310110055#
type: Reaction

metaM Lcystin c
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
type: Species
has only substance units: false
constant: false
is: CHEBI:16283
name: L-cystine
is: HMDB00192

http://identifiers.org/biomodels.db/MODEL1310110055#_6312124f_9474_45bf_b9b0_3feddbc59864
name: NDUFA5
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: Q16718
is encoded by: hsa:4698
constant: false
initial concentration: NaN

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaM sphs1p r
name: sphingosine 1-phosphate(1-)
type: Species
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB00277
is: CHEBI:60119
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_0745f59e_9e30_4ff6_8a20_dc051436d0ef
is encoded by: hsa:586
is: P54687
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: BCAT1
type: Species
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_15dee732_bf75_4314_86c8_02c34b4dd179
name: LDHAL6B
initial amount: NaN
is encoded by: hsa:92483
is: SBO:0000252
is: Q9BYZ2
constant: false
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true

metaM c51crn c
is: SBO:0000247
initial amount: NaN
is: HMDB02366
boundary condition: false
name: tiglyl carnitine
type: Species
has only substance units: false
notes: FORMULA: C12H21NO4 CHARGE: 0
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_f174c217_2a19_4fd2_a64f_1580dd62004f
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3074
has only substance units: false
name: HEXB
initial amount: NaN
is: P07686
constant: false
is: SBO:0000252
type: Species

metaR HAtly
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110055#
name: hyaluronan transport, extracellular to lysosome
reactant: MODEL1310110055#

metaR r0666
is version of: http://identifiers.org/ec-code/1.2.4.2
product: MODEL1310110055#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
is: SBO:0000176
fast: false
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1

http://identifiers.org/biomodels.db/MODEL1310110055#_0e2d904b_6a4c_4eda_b4b3_aa9a51a0ac57
name: SLC20A1
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6574
is: Q8WUM9
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
constant: false

metaM icit m
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: C00311
type: Species
initial concentration: 1.0
is: HMDB00193
is: CHEBI:16087
name: Isocitrate
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
constant: false

metaM dgmp c
is: C00362
has only substance units: false
name: dGMP
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:57673
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: HMDB01044
constant: false
initial concentration: 1.0

metaR r0779
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
product: MODEL1310110055#
kinetic law: MODEL1310110055#
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
fast: false
reversible: false

metaR GLACter
name: D-glucurono-6,3-lactone transport, endoplasmic reticulum
type: Reaction
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:3779687 NOTES:NCD
is: SBO:0000185
product: MODEL1310110055#
fast: false
is described by: ECO:0000000

metaM acgam c
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: HMDB00215
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:17411
name: N-acetyl-D-glucosamine

http://identifiers.org/biomodels.db/MODEL1310110055#_736441d0_14ba_46d2_a5c6_bc25e5f16149
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaR CMPACNAtg
is: SBO:0000185
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
reversible: true
type: Reaction
modifier: MODEL1310110055#
name: CMP-Sia Golgi transport via CMP antiport
is described by: ECO:0000269
reactant: MODEL1310110055#
product: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#

metaR OCCOAtx
fast: false
kinetic law: MODEL1310110055#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110055#
type: Reaction
is: SBO:0000185
product: MODEL1310110055#
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

http://identifiers.org/biomodels.db/MODEL1310110055#_e848bc85_106d_48a4_9d61_8a1d79b4d44d
constant: false
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:490
name: ATP2B1
is: P20020
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_87f5cc42_821d_4798_998f_4762ffc422d7
has part: E9PDD5
is encoded by: hsa:3421
has only substance units: false
is: SBO:0000297
is encoded by: hsa:3419
type: Species
initial amount: NaN
initial concentration: NaN
name: IDH3A:IDH3B:IDH3G
constant: false
boundary condition: true
has part: P50213
is encoded by: hsa:3420

metaR 5MTHFt
product: MODEL1310110055#
is: SBO:0000185
kinetic law: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
reversible: true
fast: false
is described by: ECO:0000269
reactant: MODEL1310110055#

metaM 3hbcoa m
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
initial concentration: 1.0
constant: false
is: CHEBI:57316
boundary condition: false
is: HMDB01166
type: Species
name: (S)-3-hydroxybutanoyl-CoA(4-)
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaM HC01496 m
constant: false
initial concentration: 1.0
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
is: CHEBI:28095
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 2-Amino-3-oxoadipate

metaR COAtg
type: Reaction
product: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000185
kinetic law: MODEL1310110055#
name: CoA transport in Golgi via diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
reversible: true

metaM his L e
boundary condition: false
constant: false
has only substance units: false
name: L-histidine
is: HMDB00177
is: CHEBI:15971
initial amount: NaN
type: Species
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
initial concentration: 1.0
is: SBO:0000247

metaM Lcystin e
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
name: L-cystine
is: CHEBI:16283
is: HMDB00192
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_571e6313_0071_46f9_9f3a_c775cd7128bb
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q96NR8
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:145226
name: RDH12
initial amount: NaN

metaR OCTDECCACT
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_cba50a85_af2e_4d10_8f06_737ceee30f3b
is: SBO:0000252
is encoded by: hsa:D87002
boundary condition: true
name: _D87002_1_e
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR ALDD2xm
fast: false
modifier: MODEL1310110055#
reversible: false
is: SBO:0000176
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110055#
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial

metaM c51crn e
is: HMDB02366
boundary condition: false
type: Species
name: tiglyl carnitine
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C12H21NO4 CHARGE: 0
initial concentration: 1.0
initial amount: NaN

metaR LSTO1r
product: MODEL1310110055#
reversible: false
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.21.6
type: Reaction
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
name: Lathosterol oxidase
modifier: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_1e8d2e12_4c5f_4019_9a29_7f1a53c50335
boundary condition: true
type: Species
initial amount: NaN
constant: false
name: _F23536_1_m
has only substance units: false
is encoded by: hsa:F23536
initial concentration: NaN
is: SBO:0000252

metaR TAUBETAtc
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by beta transport system
type: Reaction

metaR UDPACGALtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
reactant: MODEL1310110055#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: udpacgal intracellular transport
type: Reaction
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reversible: true

metaR CBASPte
product: MODEL1310110055#
reactant: MODEL1310110055#
name: Transport of N-carbamoyl-L-aspartate
is: SBO:0000185
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
fast: false
is described by: ECO:0000134
type: Reaction

metaR r1798
reactant: MODEL1310110055#
type: Reaction
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110055#
product: MODEL1310110055#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110055#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110055#_93f51d5e_8526_4e83_9a23_3c0422bc55af
initial amount: NaN
type: Species
is encoded by: hsa:2585
boundary condition: true
constant: false
name: GALK2
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM 34dhpac c
initial amount: NaN
name: 3,4-Dihydroxyphenylacetaldehyde
constant: false
has only substance units: false
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043
is: CHEBI:27978
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB03791

http://identifiers.org/biomodels.db/MODEL1310110055#_f3b4c984_bfdb_4429_8bfa_dc28f7a76f5b
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:27124
constant: false
boundary condition: true
initial concentration: NaN
name: INPP5J

metaR PSFLIPm
fast: false
is: SBO:0000185
reversible: false
type: Reaction
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.6.3.1
is described by: ECO:0000269
modifier: MODEL1310110055#
reactant: MODEL1310110055#
name: phosphatidylserine flippase
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ

metaM c10dc c
is: HMDB00651
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C17H30NO6 CHARGE: -1
initial amount: NaN
constant: false
name: sebacoyl carnitine
has only substance units: false
is: SBO:0000247

metaM his L c
has only substance units: false
type: Species
name: L-histidine
constant: false
initial concentration: 1.0
is: HMDB00177
boundary condition: false
is: CHEBI:15971
is: SBO:0000247
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
initial amount: NaN

metaR FAOXC101C8x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8:0)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_f53064e5_ae57_4393_8375_ff87d0a0d893
name: ACOX3
type: Species
is: O15254
is encoded by: hsa:8310
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR DOLPMT4 Ler
kinetic law: MODEL1310110055#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
reversible: false
type: Reaction
product: MODEL1310110055#

metaM trdox m
is: CHEBI:18191
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
name: Oxidized thioredoxin
has only substance units: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343

metaR NH4t3r
reversible: true
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
name: ammonia transport via proton antiport
is: SBO:0000185
fast: false
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
modifier: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
is described by: ECO:0000269

metaM na1 r
name: sodium(1+)
is: SBO:0000247
has only substance units: false
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
is: CHEBI:29101
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: HMDB00588
initial amount: NaN

metaM ksi deg8 l
initial concentration: 1.0
initial amount: NaN
type: Species
name: keratan sulfate I, degradation product 8
is: HMDB00143
boundary condition: false
is: CHEBI:12936
is: SBO:0000247
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
constant: false
has only substance units: false

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaR r1920
fast: false
name: Y+LAT2 Utilized transport
product: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110055#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#

metaR r0119
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
is described by: ECO:0000000
product: MODEL1310110055#
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
type: Reaction
reactant: MODEL1310110055#
modifier: MODEL1310110055#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/5.1.3.14
fast: false

metaR C4DCCACT
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_8ccf65f7_6bd7_4386_b3d7_ffc394af39ff
name: ACOT4
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:122970
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q8N9L9
type: Species

metaM ksii core4 pre1 g
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 1
type: Species
notes: FORMULA: C36H60N3O25X CHARGE: 0
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:28067
has only substance units: false

metaM lnlncgcoa m
constant: false
type: Species
initial amount: NaN
name: gamma-linolenoyl-CoA(4-)
boundary condition: false
is: SBO:0000247
is: CHEBI:57363
initial concentration: 1.0
has only substance units: false
is: HMDB06368
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035

metaM pail5p hs c
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: SBO:0000247
has only substance units: false
is: CHEBI:57795
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
type: Species

metaR DKMPPD
is: SBO:0000176
name: 2,3-diketo-5-methylthio-1-phosphopentane degradation reaction
is described by: ECO:0000000
product: MODEL1310110055#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:JLR- based on B. subtilis and K. pneumoniae reactions (not sure about the h2o and h)
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
fast: false

metaR r1921
modifier: MODEL1310110055#
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
product: MODEL1310110055#

metaR HISSNAT5tc
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM gln L m
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:18050
initial concentration: 1.0
is: SBO:0000247
is: HMDB00641
name: L-glutamine
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
has only substance units: false
constant: false

metaR CMPACNAtn
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
reversible: false
type: Reaction
product: MODEL1310110055#
name: CMP-Sia nuclear export
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_15c3009d_ccea_4ddb_b077_339652fb67f0
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:H17063
name: _H17063_1_c
type: Species
constant: false

metaR SPODMn
is version of: http://identifiers.org/ec-code/1.15.1.1
reactant: MODEL1310110055#
is described by: ECO:0000269
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
fast: false
reversible: false
product: MODEL1310110055#
is: SBO:0000176
name: superoxide dismutase, nuclear

metaM 4hexdtricoa x
is: HMDB02288
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species
is: SBO:0000247
name: 4,7,10-hexadecatrienoylcoa
initial amount: NaN

metaM 44mctr r
is: HMDB01023
initial amount: NaN
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
initial concentration: 1.0
is: CHEBI:17813

metaR r0661
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
is: SBO:0000176
kinetic law: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#
reversible: false
product: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:

metaM dcsptn1crn c
is: HMDB06321
name: docosa-4,7,10,13,16-pentaenoyl carnitine
type: Species
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_277bb4e6_de80_48bd_9df9_5670637df804
name: SLC2A8
initial concentration: NaN
is: SBO:0000252
is: Q9NY64
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:29988
constant: false

metaM dgmp e
constant: false
initial concentration: 1.0
is: HMDB01044
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: CHEBI:57673
initial amount: NaN
name: dGMP(2-)
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247

metaM hs deg18 l
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
initial amount: NaN
is: HMDB01352
name: heparan sulfate, degradation product 18
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:17180
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_73b174fc_1d96_407f_9114_34e44a9784f5
is: SBO:0000252
name: FLAD1
has only substance units: false
initial amount: NaN
is encoded by: hsa:80308
type: Species
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_14bdad86_3c87_4732_9543_f66f91838166
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:8776
type: Species
boundary condition: true
initial amount: NaN
is: Q13613
has only substance units: false
name: MTMR1

http://identifiers.org/biomodels.db/MODEL1310110055#_ca5cbc57_86e4_4c55_b5c8_27785751e393
initial amount: NaN
is encoded by: hsa:10087
type: Species
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: Q9Y5P4
name: COL4A3BP
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_feede8f5_2061_4e4b_b769_713079fb0c46
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:28
is: P16442
boundary condition: true
name: ABO
initial amount: NaN
constant: false
initial concentration: NaN

metaM urcan c
initial concentration: 1.0
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
has only substance units: false
is: HMDB00301
is: CHEBI:17771
is: C00785
name: Urocanate
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species

metaM dcsptn1coa x
is: http://identifiers.org/pubchem.compound/47205483
is: C16173
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
has only substance units: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
initial amount: NaN
is: HMDB06513
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false

metaR FAOXC61x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)x
type: Reaction

metaR GALASE18ly
product: MODEL1310110055#
is: SBO:0000176
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110055#
fast: false
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
name: beta-galactosidase, lysosomal

metaM ksi deg33 l
name: keratan sulfate I, degradation product 33
is: CHEBI:12936
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB00143
is: SBO:0000247
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
initial amount: NaN
boundary condition: false

metaM glcur l
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
constant: false
is: CHEBI:15748
boundary condition: false
has only substance units: false
initial amount: NaN
name: D-glucuronate
type: Species
initial concentration: 1.0
is: HMDB00127

http://identifiers.org/biomodels.db/MODEL1310110055#_6bb7b934_9c0d_42a8_bd3c_65f27f58826c
constant: false
is: SBO:0000252
initial amount: NaN
name: B3GALT5
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10317
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_c348d1e3_627c_4d3e_b489_5854ce996fe4
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: E9PAY8
is: SBO:0000252
has only substance units: false
name: PPAP2C
is encoded by: hsa:8612
constant: false

metaR SPODMm
reversible: false
product: MODEL1310110055#
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
fast: false
is described by: ECO:0000304
name: superoxide dismutase
type: Reaction
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.15.1.1

metaM pail4p hs c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
type: Species
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:58178

metaR r0660
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110055#
product: MODEL1310110055#
reversible: true
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_e7bf6c9f_5e53_4c16_90f7_41adc6a1ceed
is: SBO:0000252
has only substance units: false
name: _AI926493_1_c
is encoded by: hsa:AI926493
initial concentration: NaN
boundary condition: true
type: Species
constant: false
initial amount: NaN

metaR SIAASE3ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
name: sialidase, lysosomal
type: Reaction
fast: false
product: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: false

metaR RE0452M
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
name: RE0452
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110055#

metaR ADPCOACROT
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_5d236e56_cd85_49c3_8ad4_685aea8e0605
type: Species
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: HSD17B4
is encoded by: hsa:3295
is: E9PB82
is: SBO:0000252

metaR C16DCe
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexadecanedioic acid mono-L-carnitine ester into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_73625248_71d0_4e05_b6eb_074a4a3a5d62
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:81539
name: SLC38A1
type: Species
is: SBO:0000252
is: Q9H2H9
constant: false

metaR r1637
reversible: true
type: Reaction
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR TMDPK
is: SBO:0000176
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110055#
reversible: false
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.6.2
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110055#_6902776a_587f_439c_a58e_b4d560413cc5
constant: false
has only substance units: false
is: P43353
name: ALDH3B1
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:221

metaM hexdicoa c
is: SBO:0000247
is: HMDB02014
initial amount: NaN
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
constant: false
name: hexadecanedioylcoa
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0

metaM CE2838 e
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
is: C01936
name: maltononaose
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
constant: false

metaM pram c
name: 5-Phospho-beta-D-ribosylamine
type: Species
initial concentration: 1.0
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
is: CHEBI:58681
is: SBO:0000247
constant: false
boundary condition: false
is: C03090
is: HMDB01128
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_0ad24b86_af64_4c5f_954c_44148cf037bc
boundary condition: true
constant: false
initial amount: NaN
name: AK5
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:26289

metaR LINKDEG1ly
name: degradation of proteoglycan linkage region, lysosomal
product: MODEL1310110055#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110055#
is: SBO:0000176
reversible: false

metaM mal L m
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:15589
type: Species
name: (S)-malate(2-)
initial amount: NaN
is: HMDB00156
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146

metaM imp c
initial amount: NaN
name: IMP
is: CHEBI:58053
constant: false
boundary condition: false
is: SBO:0000247
is: C00130
type: Species
is: HMDB00175
has only substance units: false
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
initial concentration: 1.0

metaM aacoa x
is: SBO:0000247
has only substance units: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: HMDB01484
is: CHEBI:57286
boundary condition: false
name: acetoacetyl-CoA(4-)

metaM tststerone c
constant: false
boundary condition: false
is: HMDB00234
initial concentration: 1.0
is: CHEBI:17347
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
name: testosterone

metaM pe hs r
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
has only substance units: false
name: phosphatidylethanolamine
is: CHEBI:16038
initial concentration: 1.0

metaM for c
constant: false
is: HMDB00142
is: SBO:0000247
is: C00058
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
initial amount: NaN
type: Species
name: Formate
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:15740

metaM fn2m2masn g
is: CHEBI:32984
is: SBO:0000247
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
boundary condition: false
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM odecrn c
is: CHEBI:57394
type: Species
initial amount: NaN
is: C00412
name: octadecenoyl carnitine
boundary condition: false
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
constant: false
is: HMDB01114
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_47b6841a_996c_4978_a7e2_9e0bf93fff81
has only substance units: false
constant: false
is encoded by: hsa:594
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q9BQL0
initial concentration: NaN
name: BCKDHB

metaR DGCHOLte
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110055#
name: bile acid intracellular transport
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaR CDIPTr
reactant: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.11
is described by: ECO:0000000
name: phosphatidylinositol synthase (Homo sapiens)
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
fast: false
product: MODEL1310110055#
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reversible: true
is: SBO:0000176

metaR H6ET3er
type: Reaction
kinetic law: MODEL1310110055#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110055#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.8.1
reactant: MODEL1310110055#
fast: false
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
product: MODEL1310110055#

metaR r1636
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110055#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
fast: false

metaM malt e
name: Maltose
boundary condition: false
is: CHEBI:17306
initial amount: NaN
has only substance units: false
constant: false
is: C00208
type: Species
is: HMDB00163
is: SBO:0000247
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
initial concentration: 1.0

metaR S6T8g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110055#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_41532b7a_db35_439c_9c73_23b59e71d8b4
is: SBO:0000252
has only substance units: false
is: Q9H6Y6
is encoded by: hsa:4645
initial amount: NaN
boundary condition: true
name: MYO5B
type: Species
constant: false
initial concentration: NaN

metaR FAOXC184x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:4)x
type: Reaction

metaM ala B e
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
name: beta-alanine
constant: false
is: HMDB00056
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:16958

metaM cdpea c
is: HMDB01564
constant: false
boundary condition: false
notes: FORMULA: C11H19N4O11P2 CHARGE: -1 INCHI: InChI=1S/C11H20N4O11P2/c12-2-4-23-27(19,20)26-28(21,22)24-5-6-8(16)9(17)10(25-6)15-3-1-7(13)14-11(15)18/h1,3,6,8-10,16-17H,2,4-5,12H2,(H,19,20)(H,21,22)(H2,13,14,18)/p-1/t6-,8-,9-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00433 EHMN_ABBREVIATION: C00570
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:57876
initial amount: NaN
has only substance units: false
name: cdpea[c]

metaM phaccoa c
boundary condition: false
has only substance units: false
initial amount: NaN
name: phenylacetyl-CoA(4-)
is: SBO:0000247
is: CHEBI:57390
initial concentration: 1.0
type: Species
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
constant: false
is: HMDB06503

http://identifiers.org/biomodels.db/MODEL1310110055#_e2359e84_c487_4d6f_bff1_72b02c1654b5
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:2348
name: FOLR1
is: P15328
boundary condition: true
constant: false

metaM tststerone e
name: testosterone
constant: false
is: HMDB00234
type: Species
is: CHEBI:17347
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: SBO:0000247

metaR r1639
fast: false
type: Reaction
kinetic law: MODEL1310110055#
is: SBO:0000185
modifier: MODEL1310110055#
product: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110055#

metaR r0517
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
is: SBO:0000176
modifier: MODEL1310110055#
type: Reaction
product: MODEL1310110055#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is version of: http://identifiers.org/ec-code/1.17.4.1
kinetic law: MODEL1310110055#
is described by: ECO:0000000
reversible: true
fast: false

metaR LPCHOLt
type: Reaction
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
name: lysophosphatidylcholine transport
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9430701 NOTES:
reversible: true
product: MODEL1310110055#

metaM ksi pre34 g
type: Species
has only substance units: false
is: CHEBI:58053
is: HMDB00175
constant: false
is: C00130
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 34
initial amount: NaN
notes: FORMULA: C241H385N17O202S10X CHARGE: -11

metaR ADA
modifier: MODEL1310110055#
name: Adenosine deaminase
is described by: ECO:0000269
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
fast: false
is: SBO:0000176
reactant: MODEL1310110055#
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.5.4.4
type: Reaction
reversible: false

metaR GNDer
is: SBO:0000176
kinetic law: MODEL1310110055#
name: phosphogluconate dehydrogenase, endoplasmic reticulum
product: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
is described by: ECO:0000000
reversible: false
type: Reaction

metaR r1380
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
reactant: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000176

metaR MANtly
product: MODEL1310110055#
name: mannose efflux from lysosome
type: Reaction
kinetic law: MODEL1310110055#
is: SBO:0000185
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
fast: false
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_89470392_8ced_4e8e_98e8_dc9323edc843
type: Species
is: SBO:0000252
name: PLCD4
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q9BRC7
is encoded by: hsa:84812
constant: false
boundary condition: true

metaR CYTD
fast: false
product: MODEL1310110055#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
name: cytidine deaminase
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.5.4.5
kinetic law: MODEL1310110055#
is described by: ECO:0000254
type: Reaction
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_01d38da9_4fb5_41c5_94e2_eb32994a99a8
is: Q8IWX5
boundary condition: true
name: SGPP2
is encoded by: hsa:130367
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false

metaR KCC2t
kinetic law: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
is described by: ECO:0000269
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
is: SBO:0000185
product: MODEL1310110055#
name: K+-Cl- cotransporter (NH4+)
reversible: true
type: Reaction

metaR H7ET2er
reactant: MODEL1310110055#
fast: false
type: Reaction
product: MODEL1310110055#
name: H7 phosphoethanolaminyl transferase, endoplasmic reticulum
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5281.1) and (54872.1) or (5281.2) and (54872.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15632136 NOTES:NCD
reversible: false
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_9865ef5a_5998_4aec_b4f0_15614128937e
boundary condition: true
constant: false
is: Q96P26
initial amount: NaN
type: Species
name: NT5C1B
has only substance units: false
is: SBO:0000252
is encoded by: hsa:93034
initial concentration: NaN

metaR r1638
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110055#
is described by: ECO:0000000
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110055#
reversible: true
product: MODEL1310110055#
fast: false
type: Reaction

metaR NACHEX1ly
modifier: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110055#

metaM 3ivcoa c
boundary condition: false
is: C05998
is: HMDB06870
type: Species
is: http://identifiers.org/pubchem.compound/11966188
name: 3-hydroxyisovalerylcoa
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false

metaR FAOXC3DC
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: malonylcoa-->malonylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_de12ba09_8036_4d1b_82b3_363d1b814e3c
has only substance units: false
name: ALAS1
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is: P13196
is encoded by: hsa:211
initial amount: NaN
constant: false

metaM ala B c
constant: false
name: beta-alanine
is: HMDB00056
type: Species
is: CHEBI:16958
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaM 13 cis retn r
initial amount: NaN
initial concentration: 1.0
is: HMDB06219
boundary condition: false
type: Species
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
name: 13-cis-retinoate
is: SBO:0000247
constant: false
has only substance units: false
is: D00348
is: http://identifiers.org/pubchem.compound/7847414

metaM acglcgalgbside hs g
initial concentration: 1.0
type: Species
name: GlcNAc-Gal globoside
constant: false
is: SBO:0000247
is: CHEBI:26174
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0

metaR LEUKTRD4t
fast: false
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
product: MODEL1310110055#
is described by: ECO:0000269
is: SBO:0000185
name: leukotriene D4 transport
type: Reaction
reversible: true
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_c505ab9e_3a2e_47b5_9185_143ed6fc3bf1
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
name: BDH1
initial concentration: NaN
is encoded by: hsa:622

metaR RE3627M
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
type: Reaction
reversible: true
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
name: RE3627
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110055#

metaM HC01118 r
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: presqualene diphosphate(3-)
is: CHEBI:57310
constant: false
boundary condition: false
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
has only substance units: false

metaR r0157
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/6.3.4.2
modifier: MODEL1310110055#
reversible: false
fast: false
is: SBO:0000176
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_cc6c744d_38ab_480e_ac1e_39b7ab788258
boundary condition: true
constant: false
has only substance units: false
name: HSD17B10
is encoded by: hsa:3028
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q99714

metaR FAOXC123x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_6f40aa3c_e368_47fc_9f60_00d43e4295a9
boundary condition: true
type: Species
name: UGP2
has only substance units: false
constant: false
is: Q16851
initial concentration: NaN
is encoded by: hsa:7360
is: SBO:0000252
initial amount: NaN

metaR r0870
is: SBO:0000185
product: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.7.72
fast: false
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
is version of: http://identifiers.org/ec-code/3.6.4.13
is version of: http://identifiers.org/ec-code/3.1.3.4
kinetic law: MODEL1310110055#
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.1
reactant: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
name: Facilitated diffusion

metaR ETFQO
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.5.5.1
fast: false
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
is: SBO:0000176
kinetic law: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110055#

metaR GLCAASE9ly
is: SBO:0000176
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.31
name: beta-glucuronidase, lysosomal
reversible: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
modifier: MODEL1310110055#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110055#
product: MODEL1310110055#
type: Reaction

metaM ipdp c
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C00129
name: Isopentenyl diphosphate
initial amount: NaN
type: Species
is: CHEBI:128769
has only substance units: false
boundary condition: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
is: HMDB01347

metaR VALTAm
name: valine transaminase, mitochondiral
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reversible: true
modifier: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#

metaR r0512
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110055#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
modifier: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3

metaR DOLGLCP Lter
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)
is described by: ECO:0000000
kinetic law: MODEL1310110055#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
product: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000185
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_83d27c12_d9c7_4b63_868e_e1d661b8ef3f
is: O14772
initial concentration: NaN
name: FPGT
initial amount: NaN
type: Species
is encoded by: hsa:8790
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false

metaM fuc12gal14acglcgalgluside hs g
name: Type IIH glycolipid
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C50H89N2O26FULLRCO CHARGE: 0
is: HMDB00304
is: CHEBI:57847
initial amount: NaN
type: Species
is: SBO:0000247

metaM nicrns c
boundary condition: false
is: CHEBI:58527
type: Species
is: SBO:0000247
is: HMDB06809
has only substance units: false
name: Nicotinate D-ribonucleoside
initial concentration: 1.0
notes: FORMULA: C11H13NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01628 EHMN_ABBREVIATION: C05841
initial amount: NaN
constant: false

metaR 3HKYNAKGAT
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.6.1.7
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
fast: false
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
modifier: MODEL1310110055#
reactant: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000176
kinetic law: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.64
reversible: false

metaM dcsptn1coa c
is: HMDB06513
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205483
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: C16173

metaM pe hs m
constant: false
is: CHEBI:16038
has only substance units: false
initial amount: NaN
name: phosphatidylethanolamine
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
is: SBO:0000247

metaR C50CPT1
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of isovalerylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_70b1158b_80d0_4c6e_9b32_f26b7e4e3f10
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:4731
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: NDUFV3

http://identifiers.org/biomodels.db/MODEL1310110055#_309b3cfe_edf4_4846_8419_34457887fecc
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:374907
has only substance units: false
name: B3GNT8
is: Q7Z7M8
type: Species

metaM pppg9 c
is: C01079
constant: false
initial concentration: 1.0
is: HMDB01097
is: CHEBI:57307
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
name: Protoporphyrinogen IX
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
type: Species

metaM dcyt n
name: 2'-deoxycytidine
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial concentration: 1.0
is: CHEBI:15698
is: HMDB00014
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaR EX c5dc
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glutaryl carnitine
type: Reaction

metaR 3DSPHR
modifier: MODEL1310110055#
reversible: false
product: MODEL1310110055#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.102
kinetic law: MODEL1310110055#
is described by: ECO:0000269
fast: false
name: 3-Dehydrosphinganine reductase
reactant: MODEL1310110055#

metaM c226coa c
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
name: cervonyl coenzyme A
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205479
is: C16169
initial amount: NaN

metaR LNELDCCRNt
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
modifier: MODEL1310110055#
is: SBO:0000185
kinetic law: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#
product: MODEL1310110055#
fast: false
name: transport into the mitochondria (carnitine)

metaM n2m2nmasn l
notes: FORMULA: C58H96N5O40X CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
is: C04946
constant: false
boundary condition: false
has only substance units: false
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R

metaR r0400
is version of: http://identifiers.org/ec-code/1.2.4.4
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
reversible: true
kinetic law: MODEL1310110055#
is: SBO:0000176
fast: false
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
type: Reaction
modifier: MODEL1310110055#
reactant: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_272215ad_6e0c_481b_a27f_7ad43795a8da
constant: false
type: Species
is: P20933
boundary condition: true
is encoded by: hsa:175
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: AGA
initial concentration: NaN

metaM CE5236 n
type: Species
is: HMDB03952
initial amount: NaN
boundary condition: false
is: CHEBI:28002
initial concentration: 1.0
name: O2'-4a-cyclic-tetrahydrobiopterin
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236

metaR PNTOte
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of (R)-Pantothenate
reversible: true
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
product: MODEL1310110055#

metaM imp e
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: HMDB00175
has only substance units: false
is: CHEBI:58053
name: IMP(2-)
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_12d4777b_4203_4c61_8757_b723eed7edda
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:1375
name: CPT1B
is: Q53FV7
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_786cf25b_e8c3_4453_849c_4d912cdae37d
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:251
name: ALPPL2
is: SBO:0000252
is: P10696

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaR r0514
reversible: false
kinetic law: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
type: Reaction
name: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:
product: MODEL1310110055#
modifier: MODEL1310110055#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_3ea140b2_7697_4048_ae16_65fef5955a4d
is encoded by: hsa:3030
initial concentration: NaN
name: HADHA
boundary condition: true
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: E9KL44
is: SBO:0000252

metaM xol7ah2 c
type: Species
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha-diol
has only substance units: false
constant: false
is: CHEBI:28047
is: HMDB06893
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: SBO:0000247

metaR DNDPt28m
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110055#
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000185
name: dCDP transport via dGDP antiport
modifier: MODEL1310110055#

metaM for e
name: formate
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00142
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:15740
initial concentration: 1.0
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058

metaM ac e
constant: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:30089
is: HMDB00042
name: acetate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_dea3be31_19b7_482d_a545_66eba148a073
boundary condition: true
initial amount: NaN
is encoded by: hsa:5144
initial concentration: NaN
is: Q08499
constant: false
name: PDE4D
has only substance units: false
is: SBO:0000252
type: Species

metaM bilglcur r
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57767
boundary condition: false
name: mono(glucosyluronic acid)bilirubin(2-)
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
constant: false
type: Species
has only substance units: false

metaR C16DCc
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexadecanedioylcarnitine
type: Reaction

metaM omhpal c
has only substance units: false
notes: FORMULA: C16H30O3 CHARGE: -1
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB06294
boundary condition: false
is: SBO:0000247
type: Species
name: w-hydroxypalmiticacid

metaR r0156
modifier: MODEL1310110055#
reactant: MODEL1310110055#
reversible: false
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
fast: false
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.40
kinetic law: MODEL1310110055#
product: MODEL1310110055#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_74bd4c14_3986_441c_8a62_480a0acc8334
type: Species
initial amount: NaN
name: HAGH
is encoded by: hsa:3029
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q16775

metaR RE1804M
is: SBO:0000176
product: MODEL1310110055#
modifier: MODEL1310110055#
name: RE1804
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false
reversible: true
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction

metaM s2l2fn2m2masn e
is: C00255
name: PA6
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:3554
is: HMDB00244
boundary condition: false
notes: FORMULA: C90H145N6O65X CHARGE: -2
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_dd0e7651_7f14_4cf8_b551_2520540ed035
is: Q6FIH7
constant: false
initial concentration: NaN
initial amount: NaN
name: ATP5G1
is encoded by: hsa:516
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false

metaR RE0915E
name: RE0915
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.1
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.17
is: SBO:0000176
product: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
reversible: true

metaM odecrn m
initial amount: NaN
is: C00412
is: HMDB01114
name: octadecenoyl carnitine
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:57394
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
is: SBO:0000247
constant: false

metaR FACOAL191
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:11591435 NOTES:current models suggest COAL activity occurs on outer peroxisomal membrane NJ
name: fatty-acid--CoA ligase
reactant: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
reversible: false
product: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176

metaM 4nphsf e
is: SBO:0000247
type: Species
is: HMDB06492
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
has only substance units: false
is: CHEBI:35422
initial concentration: 1.0
name: 4-Nitrophenyl sulfate

http://identifiers.org/biomodels.db/MODEL1310110055#_ed76fd75_7b7b_4264_8b29_8250a2448018
constant: false
has only substance units: false
is encoded by: hsa:25769
initial amount: NaN
is: Q9UI40
name: SLC24A2
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_d2ad7b1b_cf14_4f1a_94b9_ada9fa731daa
has only substance units: false
is: Q8WYR1
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: PIK3R5
is encoded by: hsa:23533

http://identifiers.org/biomodels.db/MODEL1310110055#_3fc622dd_4864_49e3_ad3e_94f1a2868f04
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: DPM2
constant: false
is encoded by: hsa:8818
initial amount: NaN
type: Species
boundary condition: true

metaR MAN6PI
is version of: http://identifiers.org/ec-code/5.3.1.8
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110055#
modifier: MODEL1310110055#
name: mannose-6-phosphate isomerase
is: SBO:0000176
product: MODEL1310110055#
reversible: true
is described by: ECO:0000304
fast: false
type: Reaction
kinetic law: MODEL1310110055#

metaR DUTPDPn
product: MODEL1310110055#
is described by: ECO:0000269
kinetic law: MODEL1310110055#
is: SBO:0000176
name: dUTP diphosphatase, nuclear
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
reactant: MODEL1310110055#
reversible: false
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.23

http://identifiers.org/biomodels.db/MODEL1310110055#_1871ab0b_eaaa_4bd8_969a_e015e2c5c0ef
is: Q86YT5
boundary condition: true
name: SLC13A5
is encoded by: hsa:284111
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial amount: NaN

metaM naglc2p L c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C1160H1898N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
type: Species
constant: false
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human liver homolog
is: CHEBI:18278

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaR MMMm
is: SBO:0000176
reversible: true
name: methylmalonyl-CoA mutase
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
fast: false
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/5.4.99.2
is described by: ECO:0000269
modifier: MODEL1310110055#
product: MODEL1310110055#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_d17f8e85_55b4_447e_a6d3_0152128ac76c
is: E7EPT3
has only substance units: false
is encoded by: hsa:501
constant: false
name: ALDH7A1
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM xol7ah2 m
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: HMDB06893
constant: false
name: 5beta-cholestane-3alpha,7alpha-diol
is: CHEBI:28047
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species

metaM omhpal r
is: HMDB06294
has only substance units: false
notes: FORMULA: C16H30O3 CHARGE: -1
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: w-hydroxypalmiticacid
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_82774dc6_01da_455d_971a_a300a3571f73
is: P49753
has only substance units: false
boundary condition: true
name: ACOT2
is encoded by: hsa:10965
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
initial amount: NaN

metaR DHAAt1r
modifier: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
name: dehydroascorbate transport (uniport)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
fast: false
is: SBO:0000185
reversible: true

metaR r0267
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
reversible: true
is version of: http://identifiers.org/ec-code/3.5.1.9
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
product: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
fast: false
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#

metaM hmgcoa c
is: SBO:0000247
constant: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
name: Hydroxymethylglutaryl-CoA
is: CHEBI:15467
is: HMDB01375
initial amount: NaN

metaR HAS2
reversible: false
is described by: ECO:0000269
is: SBO:0000185
name: hyaluronan synthase
kinetic law: MODEL1310110055#
product: MODEL1310110055#
modifier: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.212
reactant: MODEL1310110055#
fast: false

metaM o2s x
boundary condition: false
name: superoxide
type: Species
initial amount: NaN
is: HMDB02168
is: CHEBI:18421
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704

metaM 4nphsf c
type: Species
is: SBO:0000247
is: HMDB06492
boundary condition: false
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:35422
name: 4-Nitrophenyl sulfate

http://identifiers.org/biomodels.db/MODEL1310110055#_4dfa0719_88d1_416a_b55b_822883042192
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110055#_9c3f5940_bf35_4722_ae0c_57dc8c538f02
type: Species
constant: false
is encoded by: hsa:9334
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: B4GALT5
is: O43286

http://identifiers.org/biomodels.db/MODEL1310110055#_4f0681a4_a712_45d4_a7fd_e609c4b4abf4
name: AKR1A1
is encoded by: hsa:10327
has only substance units: false
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM gam6p c
is: SBO:0000247
type: Species
is: CHEBI:12962
has only substance units: false
initial amount: NaN
is: HMDB01254
name: D-Glucosamine 6-phosphate
initial concentration: 1.0
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
constant: false
boundary condition: false

metaM prostgd2 e
name: prostaglandin D2(1-)
is: HMDB01403
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:57406
boundary condition: false
initial concentration: 1.0

metaR DNDPt39m
type: Reaction
fast: false
product: MODEL1310110055#
name: dUTP transport via dGDP antiport
kinetic law: MODEL1310110055#
reversible: false
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110055#
is: SBO:0000185
is described by: ECO:0000269

metaM subeac x
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C8H12O4 CHARGE: -2
name: suberic acid
has only substance units: false
is: HMDB00893
boundary condition: false
type: Species
is: SBO:0000247

metaM pd3 c
initial concentration: 1.0
name: Previtamin D3
is: HMDB06500
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_ae459d44_6593_43e7_9654_e503710e0114
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
name: _AV727634_1_c
is encoded by: hsa:AV727634
initial concentration: NaN

metaR r1631
product: MODEL1310110055#
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110055#
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR MI145PP
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.56
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.36
type: Reaction
reversible: false
product: MODEL1310110055#
reactant: MODEL1310110055#
name: inositol-1,4,5-trisphosphate 5-phosphatase
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.1.3.86

metaR RE0512M
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110055#
reversible: true
kinetic law: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
modifier: MODEL1310110055#
is: SBO:0000176
name: RE0512
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107

http://identifiers.org/biomodels.db/MODEL1310110055#_d6a8539e_f722_4a76_9fb2_d8e45914f794
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8704
type: Species
has only substance units: false
name: B4GALT2
is: O60909
constant: false
initial amount: NaN
initial concentration: NaN

metaR r1630
fast: false
kinetic law: MODEL1310110055#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110055#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_c749d359_d5a8_4f5a_b9a9_987d05728e87
has part: P37287
initial amount: NaN
is encoded by: hsa:8818
initial concentration: NaN
type: Species
is encoded by: hsa:5277
has only substance units: false
is: SBO:0000297
boundary condition: true
constant: false
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ

http://identifiers.org/biomodels.db/MODEL1310110055#_ba092019_df84_454c_bc57_8ad4a81a9f7a
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:343
has only substance units: false
is: O94778
name: AQP8
boundary condition: true
is: SBO:0000252
constant: false

metaR VD3
reversible: true
name: Vitamin D3 formation
fast: false
reactant: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
kinetic law: MODEL1310110055#

metaR LTD4DP
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
name: Leukotriene D4 dipeptidase
reversible: true
reactant: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_f207f0ca_cf42_4301_9b90_0a0ed6fefad9
type: Species
is: F5H8B1
initial concentration: NaN
is: SBO:0000252
name: PCYT2
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:5833

http://identifiers.org/biomodels.db/MODEL1310110055#_d3676af7_b339_42db_93c8_d20e3a6b0e84
is: Q92959
is encoded by: hsa:6578
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
name: SLCO2A1

metaR TIGCRNe
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tiglyl carnitine into the extra cellular fluid
type: Reaction

metaM itacon m
name: itaconate(2-)
is: HMDB02092
is: CHEBI:17240
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_83926484_384b_482c_b732_8855b81049a7
is encoded by: hsa:762
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q6FHI7
boundary condition: true
name: CA4
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_968ef944_5e15_4ea5_8148_0ba3c903acb2
has only substance units: false
initial concentration: NaN
name: PIGP
is encoded by: hsa:51227
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR SERGLYexR
modifier: MODEL1310110055#
reversible: true
is: SBO:0000185
name: L-Serine/Glycine reversible exchange
fast: false
reactant: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110055#
is described by: ECO:0000304
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_3e3326ed_68cb_4317_97bc_f6388ca680d6
initial amount: NaN
has only substance units: false
is: P41247
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8228
type: Species
name: PNPLA4
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_03545571_1f9e_4c7f_b5e8_7772bbe468a7
name: SLC5A5
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: Q92911
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6528

metaR r1633
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110055#
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110055#
is described by: ECO:0000000

metaR MI3PP
product: MODEL1310110055#
name: myo-inositol 3-phosphatase
reversible: false
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.1.3.25
type: Reaction
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
fast: false
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_061af863_2281_4ade_a619_668835947083
name: HSD11B1
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:3290
constant: false
initial concentration: NaN
type: Species

metaM prostgd2 c
is: HMDB01403
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: CHEBI:57406
is: SBO:0000247
name: prostaglandin D2(1-)
boundary condition: false

metaR FTHFDH
is: SBO:0000176
fast: false
kinetic law: MODEL1310110055#
name: formyltetrahydrofolate dehydrogenase
product: MODEL1310110055#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10840.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.6 Confidence Level: 4 AUTHORS: PMID:2733692 NOTES:IT
is version of: http://identifiers.org/ec-code/1.5.1.6
modifier: MODEL1310110055#
type: Reaction
reversible: false
reactant: MODEL1310110055#

metaR ACGAMK
is version of: http://identifiers.org/ec-code/2.7.1.59
is: SBO:0000176
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
fast: false
type: Reaction
product: MODEL1310110055#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
modifier: MODEL1310110055#
name: N-acetylglucosamine kinase

metaR PAIL HStn
type: Reaction
fast: false
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
product: MODEL1310110055#
name: phosphatidylinositol nuclear transport (diffusion)
reversible: true

metaR ATPH2e
is described by: ECO:0000269
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (954.2) or (954.1) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.5
is version of: http://identifiers.org/ec-code/3.6.1.6
is: SBO:0000176
name: ATP diphosphohydrolase
product: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction

metaR CYTDK2m
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reversible: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
name: cytidine kinase (ATP), mitochondrial
fast: false
is described by: ECO:0000000
product: MODEL1310110055#

metaM 3m4hpga c
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
is: C05583
is: HMDB04061
is: http://identifiers.org/pubchem.compound/7909
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
boundary condition: false
constant: false
is: SBO:0000247

metaM 4nph c
name: 4-nitrophenolate
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB01232
is: CHEBI:57917
type: Species
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
initial amount: NaN
constant: false
is: SBO:0000247

metaM od2coa c
constant: false
is: C16218
is: CHEBI:50570
has only substance units: false
is: HMDB06529
type: Species
name: trans-Octadec-2-enoyl-CoA
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR r1527
kinetic law: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
product: MODEL1310110055#
modifier: MODEL1310110055#
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.1
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

metaM ksii core2 pre5 g
notes: FORMULA: C61H99N5O43X CHARGE: -1
type: Species
is: C00130
is: CHEBI:58053
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 5
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM srtn e
name: serotonin(1+)
initial concentration: 1.0
is: CHEBI:350546
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
constant: false
is: HMDB00259
initial amount: NaN
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_5afdef8d_e1ab_41e2_ab32_eca0b9522943
has only substance units: false
initial concentration: NaN
is: A0PJJ9
name: GGT7
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:2686
constant: false
boundary condition: true

metaR r1632
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
product: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110055#
type: Reaction
fast: false
reactant: MODEL1310110055#
is described by: ECO:0000000

metaR ACNAMPH
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110055#
fast: false
product: MODEL1310110055#
name: N-Acetylneuraminate 9-phosphate phosphohydrolase
type: Reaction
reversible: false
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_5f0c9eac_af7a_4ffd_8b56_d09ae13f18b6
name: MPST
initial amount: NaN
is encoded by: hsa:4357
boundary condition: true
has only substance units: false
type: Species
is: P25325
initial concentration: NaN
is: SBO:0000252
constant: false

metaM glutcoa m
has only substance units: false
is: HMDB01339
is: CHEBI:57378
boundary condition: false
type: Species
name: glutaryl-CoA(5-)
initial concentration: 1.0
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
constant: false
is: SBO:0000247
initial amount: NaN

metaR r0407
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.5
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
modifier: MODEL1310110055#
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000176
type: Reaction
reversible: true
reactant: MODEL1310110055#
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
is described by: ECO:0000000

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

metaR G14T2g
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
product: MODEL1310110055#
reversible: false
reactant: MODEL1310110055#
modifier: MODEL1310110055#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

http://identifiers.org/biomodels.db/MODEL1310110055#_2e3b4152_2f86_4d87_8eff_e2e5be3390aa
has part: Q6IB04
is: SBO:0000297
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:84720
name: PIGF:PIGO
is encoded by: hsa:5281
boundary condition: true
initial amount: NaN
has only substance units: false

metaR ADEt
kinetic law: MODEL1310110055#
name: adenine reversible transport, cytosol
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110055#
is: SBO:0000185
product: MODEL1310110055#
modifier: MODEL1310110055#
fast: false

metaR GLYOX
reactant: MODEL1310110055#
reversible: false
modifier: MODEL1310110055#
type: Reaction
name: hydroxyacylglutathione hydrolase
notes: GENE_ASSOCIATION: (3029.1) or (84264.2) or (84264.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.6 Confidence Level: 4 AUTHORS: PMID:15117945,PMID:8550579 NOTES:IF
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.1.2.6
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110055#
fast: false

metaR ASPPROASCT1
reactant: MODEL1310110055#
fast: false
is: SBO:0000185
is described by: ECO:0000134
type: Reaction
product: MODEL1310110055#
reversible: false
name: aspartate intake by system ASCT-1 transporter
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#

metaR EX ksi deg1 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I, degradation product 1 exchange
type: Reaction

metaR B3GNT33g
modifier: MODEL1310110055#
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
fast: false
type: Reaction
product: MODEL1310110055#
is described by: ECO:0000269

metaM ksi pre12 g
is: C00130
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00175
is: CHEBI:58053
is: SBO:0000247
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
name: keratan sulfate I biosynthesis, precursor 12
initial concentration: 1.0
has only substance units: false

metaR ANTHte
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110055#
type: Reaction
name: Transport of anthranilate
kinetic law: MODEL1310110055#
is described by: ECO:0000134
fast: false
reversible: true
reactant: MODEL1310110055#

metaR r0268
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
product: MODEL1310110055#
is: SBO:0000176
modifier: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.1
reactant: MODEL1310110055#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.2
fast: false
kinetic law: MODEL1310110055#
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2

metaM pap c
initial concentration: 1.0
is: HMDB00061
has only substance units: false
name: adenosine 3',5'-bismonophosphate(4-)
is: CHEBI:58343
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054

http://identifiers.org/biomodels.db/MODEL1310110055#_adaa4da2_9181_4643_a246_74d066b66438
is: SBO:0000252
is: P54819
is encoded by: hsa:204
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: AK2
boundary condition: true

metaM 4nph e
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
initial concentration: 1.0
is: CHEBI:57917
name: 4-nitrophenolate
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB01232
boundary condition: false

metaM HC02217 e
constant: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial amount: NaN
has only substance units: false
name: prostaglandin-g2
boundary condition: false
is: SBO:0000247
is: CHEBI:27647
initial concentration: 1.0
type: Species

metaM pppg9 m
constant: false
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
type: Species
name: Protoporphyrinogen IX
initial amount: NaN
is: C01079
is: CHEBI:57307
is: SBO:0000247
is: HMDB01097
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR r1635
reversible: true
product: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
modifier: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_cf1fd4a8_649a_40fd_b797_328201aff8ef
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR GBA
type: Reaction
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.45
is described by: ECO:0000000
modifier: MODEL1310110055#
name: Glucosylceramidase
reversible: false
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ

metaR GASNASEly
is version of: http://identifiers.org/ec-code/3.5.1.26
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110055#
name: glycosylasparaginase, lysosomal
reactant: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110055#

metaM aacoa m
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB01484
name: acetoacetyl-CoA(4-)
is: SBO:0000247
is: CHEBI:57286
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
boundary condition: false
type: Species
has only substance units: false

metaR AICARte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
product: MODEL1310110055#
is described by: ECO:0000134
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#

metaR r0408
modifier: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000176
fast: false
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
type: Reaction
reversible: true
product: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.4.3.5

metaR FAS80COA L
product: MODEL1310110055#
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
reactant: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000269
type: Reaction

metaM hs deg14 l
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:16126
name: heparan sulfate, degradation product 14

metaM etoh e
name: ethanol
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
initial concentration: 1.0
is: HMDB00108
is: CHEBI:16236
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_48d0ae64_6d09_4673_bb00_1860f9c1f67f
initial amount: NaN
is encoded by: hsa:LOC647190
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species
name: _LOC647190_1_c
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_d4b460f5_9205_4cdf_a126_2d787549400c
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:8898
has only substance units: false
name: MTMR2
is: A6NN98

metaM pristcoa c
boundary condition: false
name: pristanoyl coa
constant: false
is: CHEBI:51341
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
is: SBO:0000247

metaR r1634
type: Reaction
reversible: true
kinetic law: MODEL1310110055#
product: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110055#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_e3994d3d_652c_40e4_9d19_e2870246a4a4
is: Q6IBE6
constant: false
name: ST3GAL4
boundary condition: true
is encoded by: hsa:6484
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaR 2DR1PP
type: Reaction
kinetic law: MODEL1310110055#
name: 2-deoxy-D-ribose 1-phosphate phosphorylase
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
reactant: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000176

metaM tststerone r
initial amount: NaN
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: SBO:0000247
is: HMDB00234
boundary condition: false
is: CHEBI:17347
name: testosterone

metaM ac m
is: SBO:0000247
has only substance units: false
is: HMDB00042
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
boundary condition: false
name: acetate
is: CHEBI:30089
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_a6e99aba_b2d1_44c7_b9bd_690d960cb2f4
initial concentration: NaN
constant: false
is: Q9NZK7
type: Species
is encoded by: hsa:30814
name: PLA2G2E
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR G5SDym
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 1.2.1.41 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m TDV: name change from G5SDm
fast: false
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.2.1.41
reversible: false
name: glutamate-5-semialdehyde dehydrogenase (m)
modifier: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
type: Reaction
is described by: ECO:0000254

metaR CYSSERNaEx
kinetic law: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
reactant: MODEL1310110055#
reversible: false
name: L-serine/L-cysteine Na-dependent exchange (Cys-L in)
fast: false
is: SBO:0000185
product: MODEL1310110055#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaM m2mpdol L c
initial concentration: 1.0
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:28049
has only substance units: false
notes: FORMULA: C1420H2328N20O320P20 CHARGE: -20
type: Species

metaR r0409
modifier: MODEL1310110055#
is: SBO:0000176
product: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
name: UTP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275 NOTES:
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.10
fast: false

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_ea11add3_ec16_4560_b0a0_420e86632766
is: SBO:0000252
is encoded by: hsa:2643
is: Q8IZH9
has only substance units: false
initial amount: NaN
name: GCH1
type: Species
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_01bcc97e_59e2_4fe2_8943_f21c648bb3b7
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: PDE3B
initial amount: NaN
is encoded by: hsa:5140
type: Species
has only substance units: false
constant: false
is: A7E2E5

http://identifiers.org/biomodels.db/MODEL1310110055#_ef55341e_36bd_473e_b881_f981bd1ba33a
has part: B4E3E9
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:4967
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000297
name: DLD:DLST:OGDH:PDHX

http://identifiers.org/biomodels.db/MODEL1310110055#_41539257_0e93_4b8f_8781_0677ba15fa8e
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5137
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: Q8NB10
name: PDE1C
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_11dc5e9f_ab50_426f_8246_ff70fbcee9ef
type: Species
name: IDH3B
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:3420
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM lanost r
has only substance units: false
is: CHEBI:16521
initial amount: NaN
constant: false
is: SBO:0000247
name: lanosterol
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB01251

http://identifiers.org/biomodels.db/MODEL1310110055#_31bc0562_d2e0_4e98_9108_bd5126d499e9
is encoded by: hsa:6818
is: SBO:0000252
name: SULT1A3
initial amount: NaN
has only substance units: false
constant: false
is: P50224
initial concentration: NaN
boundary condition: true
type: Species

metaR Coqe
type: Reaction
fast: false
reversible: true
is: SBO:0000185
name: Transport of q10
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110055#_f15100dd_a51e_46be_bb12_0f2706aeb145
is encoded by: hsa:2589
is: Q10472
initial concentration: NaN
type: Species
is: SBO:0000252
name: GALNT1
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true

metaR BALABETAtc
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of beta alanine into the intestinal cells by beta transport system
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_ce2f88e5_52af_4966_adfe_7a5da963705c
constant: false
is: SBO:0000252
name: ABCB4
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: A4D1D5
is encoded by: hsa:5244

http://identifiers.org/biomodels.db/MODEL1310110055#_db92c911_0f54_4c62_bf26_3d6a16d1d1af
is: Q8IX04
is: SBO:0000252
name: UEVLD
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:55293
initial amount: NaN
has only substance units: false

metaR ENGASE3ly
name: endo-beta-N-acetylglucosaminidase, lysosomal
fast: false
is described by: ECO:0000000
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: false
product: MODEL1310110055#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD

metaR HSAT2ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
reactant: MODEL1310110055#
fast: false
name: heparan-glucosaminide N-acetyltransferase, lysosomal
kinetic law: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: false

metaM xol7ah c
is: CHEBI:2290
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
is: HMDB06892
is: SBO:0000247
name: 7alpha-hydroxy-5beta-cholestan-3-one

metaR DGK1
fast: false
reactant: MODEL1310110055#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.8
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reversible: true
name: deoxyguanylate kinase (dGMP:ATP)
is: SBO:0000176
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction

metaR GALGALGALTHCRMte
is described by: ECO:0000000
name: galgalgalthcrm hs transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
is: SBO:0000185
product: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
kinetic law: MODEL1310110055#
fast: false
type: Reaction

metaM c101crn e
type: Species
constant: false
is: HMDB13205
initial concentration: 1.0
notes: FORMULA: C17H31NO4 CHARGE: 0
has only substance units: false
boundary condition: false
name: decenoyl carnitine
is: SBO:0000247
initial amount: NaN

metaM prgstrn c
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410
boundary condition: false
name: progesterone
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: HMDB01830
is: CHEBI:17026
has only substance units: false

metaM etoh c
is: CHEBI:16236
is: HMDB00108
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
constant: false
type: Species
has only substance units: false
boundary condition: false
name: ethanol
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_e95014d0_9acc_4265_819b_3eabee456c56
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q99999
is encoded by: hsa:9514
name: GAL3ST1
is: SBO:0000252

metaM HC02217 c
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:27647
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
name: prostaglandin-g2
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956

metaR THFtm
reactant: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is: SBO:0000185
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110055#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_bbd4efed_13d7_4748_994f_c74a6386075f
constant: false
is: O43426
boundary condition: true
name: SYNJ1
initial amount: NaN
is encoded by: hsa:8867
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR DCSPTN1CRNt
product: MODEL1310110055#
reversible: false
modifier: MODEL1310110055#
fast: false
name: transport into the mitochondria (carnitine)
reactant: MODEL1310110055#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110055#

metaR PPCDC
fast: false
is described by: ECO:0000269
reactant: MODEL1310110055#
product: MODEL1310110055#
name: phosphopantothenoylcysteine decarboxylase
kinetic law: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.36
reversible: false
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
modifier: MODEL1310110055#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_3669f4aa_6797_4834_856e_287110bca599
name: SLC5A11
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:115584
initial concentration: NaN
constant: false
is: Q8WWX8

metaM udpacgal g
is: SBO:0000247
initial amount: NaN
type: Species
name: UDP-N-acetyl-D-galactosamine(2-)
is: CHEBI:57847
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00304
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203

metaM od2coa m
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB06529
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h18-19,26-28,32-34,38,49-50H,4-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b19-18+/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE2244
is: CHEBI:50570
name: trans-Octadec-2-enoyl-CoA
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR AMANK
modifier: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
reversible: false
notes: GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES:JLR - Kegg R02705
reactant: MODEL1310110055#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
name: N-acetyl-D-mannosamine kinase
is version of: http://identifiers.org/ec-code/5.1.3.14
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.1.59

metaR FADH2ETC
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110055#
type: Reaction
fast: false
name: Complex II reaction for respiratory chain
reactant: MODEL1310110055#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110055#

metaR RE2079R
reversible: true
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
name: RE2079
is: SBO:0000176
reactant: MODEL1310110055#
product: MODEL1310110055#
fast: false
type: Reaction
is described by: ECO:0000000

metaM srtn c
initial amount: NaN
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
type: Species
is: HMDB00259
name: serotonin(1+)
is: CHEBI:350546
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false

metaM cs e deg1 l
is: HMDB00868
type: Species
has only substance units: false
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57737
boundary condition: false

metaM dlnlcgcoa c
constant: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
has only substance units: false
boundary condition: false
type: Species
name: dihomo-gamma-linolenyl coenzyme A
is: SBO:0000247
is: CHEBI:27979
initial concentration: 1.0
initial amount: NaN

metaR 2AMADPTm
modifier: MODEL1310110055#
is described by: ECO:0000269
product: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
is: SBO:0000185
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
type: Reaction
fast: false
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_5af2129e_d69a_467d_9b89_c9de77886f83
is: SBO:0000252
is encoded by: hsa:126328
name: NDUFA11
is: C9JT23
initial amount: NaN
type: Species
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false

metaM sucr e
is: HMDB00258
has only substance units: false
name: Sucrose
type: Species
initial amount: NaN
is: SBO:0000247
is: C00089
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00091 EHMN_ABBREVIATION: C00089
is: CHEBI:17992

metaM ha deg1 l
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16336
notes: FORMULA: C22H33N2O16 CHARGE: -1
constant: false
type: Species
name: hyaluronan degradation product 1

metaR FAOXC184C163x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_e76308ec_db06_4912_bea9_1e613b047c2c
is: P51553
constant: false
initial amount: NaN
name: IDH3G
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3421
boundary condition: true
has only substance units: false
type: Species

metaR GALGALGALTHCRMtg
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
product: MODEL1310110055#
reversible: true
fast: false
kinetic law: MODEL1310110055#
type: Reaction
name: galgalgalthcrm hs intracellular transport

metaM 2decdicoa x
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
name: 2,7-decadienoylcoa
is: http://identifiers.org/pubchem.compound/16019966

metaM hexdicoa r
boundary condition: false
constant: false
name: hexadecanedioylcoa
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: C08260
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
is: SBO:0000247
is: HMDB00672

metaR r1492
name: Utilized transport
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110055#
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false

metaM prgstrn e
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410
initial amount: NaN
name: progesterone
constant: false
type: Species
is: HMDB01830
is: CHEBI:17026
initial concentration: 1.0

metaM 2octdectecoa x
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
type: Species
is: SBO:0000247
name: 2,6,9,12-octadecatetraenoylcoa
is: http://identifiers.org/pubchem.compound/5280355
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_d5a78379_043f_4766_b124_aecf563e82ef
is: Q99714
is encoded by: hsa:3028
constant: false
initial concentration: NaN
name: HSD17B10
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_71a8fa67_9e1c_4b6f_8d01_396b689a9de8
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaR GHMT2rm
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
product: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110055#
name: glycine hydroxymethyltransferase, reversible, mitochondrial
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.1
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110055#_df8084c1_e2b5_4903_a5ae_cc1731b33f25
initial amount: NaN
name: PDE2A
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:5138
is: Q8IW54

metaR GDPFUCtg
fast: false
name: GDPFuc Golgi transport via CMP antiport
modifier: MODEL1310110055#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
product: MODEL1310110055#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD

metaR PI45P4P
reactant: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
fast: false
is: SBO:0000176
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reversible: false
is described by: ECO:0000000
name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase

http://identifiers.org/biomodels.db/MODEL1310110055#_3702411a_f55e_4e02_931a_4ece783e9c03
boundary condition: true
type: Species
is encoded by: hsa:2990
is: P08236
initial concentration: NaN
constant: false
name: GUSB
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR r2018
is described by: ECO:0000000
reactant: MODEL1310110055#
is: SBO:0000185
modifier: MODEL1310110055#
reversible: false
type: Reaction
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
product: MODEL1310110055#

metaR FAOXC101x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)x
type: Reaction

metaR LEUGLYHYc
reactant: MODEL1310110055#
fast: false
is: SBO:0000176
reversible: true
product: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
name: hydrolysis of leucylglycine
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110055#_bf81c8a0_6fbf_44da_a61d_41ec73825d2a
name: DCK
constant: false
is encoded by: hsa:1633
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
is: P27707

metaR EX estradiol LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: estradiol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_1ab79638_2072_4296_a07b_3c3388518ac0
is: SBO:0000252
name: _AF080579_1_c
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:AF080579
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_78129c16_bffd_40ad_a796_d84aeffcbe9a
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:51292
constant: false
is: SBO:0000252
boundary condition: true
is: Q86T14
name: GMPR2

metaM hmgcoa x
initial amount: NaN
constant: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
boundary condition: false
is: SBO:0000247
type: Species
name: Hydroxymethylglutaryl-CoA
is: HMDB01375
initial concentration: 1.0
is: CHEBI:15467
has only substance units: false

metaR ACOX22x
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 2 AUTHORS: PMID:11181649 NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 analog as per KEGG added NJ
modifier: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000176
is described by: ECO:0000304
kinetic law: MODEL1310110055#
fast: false
name: acyl-Coenzyme A oxidase 2, branched chain
is version of: http://identifiers.org/ec-code/1.17.99.3

http://identifiers.org/biomodels.db/MODEL1310110055#_01255432_f262_40dc_b7b8_b79b2c8a4aaf
has only substance units: false
name: SLC6A5
is: SBO:0000252
is encoded by: hsa:9152
boundary condition: true
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: Q9Y345

http://identifiers.org/biomodels.db/MODEL1310110055#_c57fa33f_6002_45bd_b035_19abf6911277
name: HK1
is encoded by: hsa:3098
boundary condition: true
constant: false
is: P78542
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR G5SADrm
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
product: MODEL1310110055#
type: Reaction
reversible: true
kinetic law: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
fast: false
is: SBO:0000176

metaR PItn
type: Reaction
fast: false
kinetic law: MODEL1310110055#
reversible: true
name: phosphate transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#
is: SBO:0000185

metaR PYK
product: MODEL1310110055#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
name: pyruvate kinase
modifier: MODEL1310110055#
is described by: ECO:0000134
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_58222274_0f01_4be4_8837_7637aa930322
type: Species
initial concentration: NaN
is encoded by: hsa:1607
name: DGKB
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM dmnoncrn m
is: SBO:0000247
is: HMDB06202
initial amount: NaN
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
constant: false
name: 4,8 dimethylnonanoyl carnitine
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_f725e424_3aee_41e7_bdb9_c4f3823e970c
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q9H2X9
is encoded by: hsa:57468
initial concentration: NaN
name: SLC12A5
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_7f5a5a57_7deb_48b2_bd74_a0df2c2bda21
constant: false
is encoded by: hsa:4830
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: NME1
is: P15531
initial amount: NaN
type: Species
boundary condition: true

metaM glyc3p c
constant: false
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: C00093
initial concentration: 1.0
is: CHEBI:57597
is: HMDB00126
type: Species
name: Glycerol 3-phosphate
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_fbd6e2ea_e374_45a2_9def_59eb85d800c0
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:H17063
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
name: _H17063_1_m

http://identifiers.org/biomodels.db/MODEL1310110055#_cbe6fb7c_9c76_43a9_b205_1dd4789d4668
initial concentration: NaN
type: Species
initial amount: NaN
name: IDS
is: B4DGD7
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:3423
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_1c94a4bf_6534_4493_a911_a47eab6f701d
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
name: _728637_1_c
type: Species
is encoded by: hsa:728637
initial concentration: NaN

metaM aacoa c
constant: false
initial concentration: 1.0
is: C00332
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: Acetoacetyl-CoA
type: Species
is: HMDB01484
is: CHEBI:57286

metaM maltpt e
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5141
constant: false
is: HMDB01296
is: SBO:0000247
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
has only substance units: false
is: C02052
name: maltopentaose
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_metaR_EX_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIAb exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_21e48c10_3ef9_4947_86ab_a95197267766
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3081
initial amount: NaN
constant: false
initial concentration: NaN
is: Q93099
name: HGD

metaM udpacgal c
type: Species
name: UDP-N-acetyl-D-galactosamine(2-)
initial concentration: 1.0
is: CHEBI:57847
constant: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB00304
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_c0ee30e5_9f91_491c_a37f_75e842ed1876
constant: false
initial amount: NaN
type: Species
name: NUDT12
is: Q9BQG2
has only substance units: false
is encoded by: hsa:83594
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR NACHEXA14ly
is: SBO:0000176
name: beta-N-acetylhexosaminidase A, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reactant: MODEL1310110055#
modifier: MODEL1310110055#
product: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#
fast: false
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_6224cfaa_d091_44d1_9e2c_2f09f0411d05
initial amount: NaN
has only substance units: false
is encoded by: hsa:2643
is: Q8IZH9
boundary condition: true
initial concentration: NaN
type: Species
name: GCH1
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_e77882d6_ddcc_47f7_9bb4_ad1ebdebe656
is: Q9UIG8
has only substance units: false
initial concentration: NaN
constant: false
name: SLCO3A1
is: SBO:0000252
is encoded by: hsa:28232
type: Species
boundary condition: true
initial amount: NaN

metaM c4dc x
initial amount: NaN
is: HMDB02013
constant: false
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/213144
is: C02862
is: SBO:0000247
type: Species
notes: FORMULA: C11H18NO6 CHARGE: -1
boundary condition: false
name: succinyl carnitine

metaM gluside hs g
type: Species
constant: false
name: D-glucosyl-N-acylsphingosine
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18368
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_799c75cd_cc19_4396_966f_ca945a90229f
type: Species
name: SLC7A10:SLC3A2
constant: false
is encoded by: hsa:56301
has part: Q9NS82
has part: P08195
has only substance units: false
initial amount: NaN
is encoded by: hsa:6520
boundary condition: true
initial concentration: NaN
is: SBO:0000297

metaM c101crn c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C17H31NO4 CHARGE: 0
is: SBO:0000247
has only substance units: false
name: decenoyl carnitine
boundary condition: false
is: HMDB13205
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_c0b943dc_fcf2_41fb_b0da_164393f65283
is encoded by: hsa:8525
is: B7Z6M3
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: DGKZ

http://identifiers.org/biomodels.db/MODEL1310110055#_89a3a393_b5ca_4911_895a_1f5ea30c07aa
is: P17752
type: Species
is encoded by: hsa:7166
boundary condition: true
constant: false
name: TPH1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR MI145PK
kinetic law: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
reactant: MODEL1310110055#
modifier: MODEL1310110055#
fast: false
reversible: false
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110055#
name: inositol-1,4,5-trisphosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.127

http://identifiers.org/biomodels.db/MODEL1310110055#_949357e0_2abe_4bd7_8c41_8da40952662f
is encoded by: hsa:6566
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
name: SLC16A1
initial concentration: NaN
is: B4DKS0

metaR ATP2ter
reversible: true
product: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
is: SBO:0000185
kinetic law: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
name: AMP/ATP transporter, endoplasmic reticulum

metaR B MANNASEly
name: beta-mannosidase, lysosomal
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.25
product: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
modifier: MODEL1310110055#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110055#

metaR GALASE11ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110055#
name: beta-galactosidase, lysosomal
product: MODEL1310110055#
reversible: false
type: Reaction
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
reactant: MODEL1310110055#

metaM HC00460 c
has only substance units: false
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
initial amount: NaN
boundary condition: false
name: 2,5-dihydroxybenzoate
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:58044

metaM bilglcur c
is: CHEBI:57767
boundary condition: false
is: SBO:0000247
name: mono(glucosyluronic acid)bilirubin(2-)
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
has only substance units: false

metaR r1497
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:11819755,PMID:17404808,PMID:6384004 NOTES:
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000185
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_b59f36d6_4894_46e2_8090_8f1a05fcfba8
type: Species
constant: false
boundary condition: true
name: GPX2
is: P18283
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:2877
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_fd555a7b_a743_4999_98d6_fd507aa1d8e5
is: Q9NVE7
is encoded by: hsa:55229
name: PANK4
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_a020c51e_2659_433a_9344_5f3eafe45d52
is encoded by: hsa:10007
name: GNPDA1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: P46926
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_metaR_GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEte
type: Reaction
fast: false
name: blood group intracellular transport
is: SBO:0000185
product: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is described by: ECO:0000000
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#

metaM CE2431 m
is: CHEBI:57795
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
name: cis-deca-4-enoyl-CoA
type: Species
is: SBO:0000247

metaR RE0453N
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110055#
name: RE0453
reactant: MODEL1310110055#
product: MODEL1310110055#
fast: false
modifier: MODEL1310110055#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:

metaR ALAyLATthc
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Alanine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaR HSD3A1r
is version of: http://identifiers.org/ec-code/1.1.1.225
product: MODEL1310110055#
reversible: true
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
type: Reaction
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
fast: false
is described by: ECO:0000269
modifier: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_ae384a61_ac36_46c4_8dff_afa6c135decc
initial amount: NaN
is: SBO:0000252
is: Q9NY59
initial concentration: NaN
is encoded by: hsa:55512
constant: false
type: Species
has only substance units: false
boundary condition: true
name: SMPD3

metaM HC01401 m
boundary condition: false
name: (S)-3-Hydroxydodecanoyl-CoA
is: CHEBI:27668
has only substance units: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
initial concentration: 1.0
initial amount: NaN

metaM dlnlcgcoa m
type: Species
has only substance units: false
is: CHEBI:27979
initial amount: NaN
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
name: dihomo-gamma-linolenyl coenzyme A
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false

metaM mal L c
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: (S)-malate(2-)
is: HMDB00156
constant: false
is: CHEBI:15589
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146

metaM ipdp x
has only substance units: false
constant: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
is: CHEBI:128769
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
name: isopentenyl diphosphate(3-)
initial concentration: 1.0
is: HMDB01347

metaR CYTK13
is: SBO:0000176
modifier: MODEL1310110055#
reversible: true
reactant: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000269
fast: false
name: cytidylate kinase (dCMP,dATP)
kinetic law: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR DURAD2
is version of: http://identifiers.org/ec-code/1.3.1.2
is: SBO:0000176
kinetic law: MODEL1310110055#
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
is described by: ECO:0000269
modifier: MODEL1310110055#
name: dihydrothymin dehydrogenase (NADP)
reactant: MODEL1310110055#
product: MODEL1310110055#

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaR PHYHx
product: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5264.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.14.11.18 Confidence Level: 4 AUTHORS: PMID:8954107,PMID:9326940 NOTES:NJ
type: Reaction
reactant: MODEL1310110055#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110055#
name: Phytanoyl-CoA dioxygenase, peroxisomal
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.14.11.18
reversible: false

metaR Ser Thrtg
is described by: ECO:0000269
reactant: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
type: Reaction
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reversible: true
fast: false
name: Ser/Thr transport (from golgi to lysosome)

metaM mal L e
is: HMDB00156
has only substance units: false
initial concentration: 1.0
constant: false
name: (S)-malate(2-)
is: CHEBI:15589
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN

metaM c12dccoa x
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
constant: false
has only substance units: false
initial concentration: 1.0
name: dodecanedioylcoa
is: SBO:0000247
is: HMDB03712

metaR KHte
is: SBO:0000185
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
reversible: true
name: KHte
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110055#

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaM ksi pre23 g
constant: false
type: Species
name: keratan sulfate I biosynthesis, precursor 23
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:28067
initial concentration: 1.0
notes: FORMULA: C185H296N13O153S7X CHARGE: -8

metaR r2012
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
modifier: MODEL1310110055#
is: SBO:0000185
fast: false
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaM bilglcur e
is: CHEBI:57767
type: Species
constant: false
is: SBO:0000247
name: mono(glucosyluronic acid)bilirubin(2-)
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374

metaM hs deg23 l
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: HMDB02704
notes: FORMULA: C31H49NO29S CHARGE: -2
is: CHEBI:21338
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_3b78fe19_ab56_4b0b_a797_eb35edc9cc19
initial concentration: NaN
is: B4E3E9
name: OGDH
has only substance units: false
constant: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4967

metaR CYTK14
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reactant: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000269
fast: false
name: cytidylate kinase (dCMP,UTP)
is: SBO:0000176
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true

metaR r0651
product: MODEL1310110055#
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.2
fast: false
kinetic law: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#
reversible: true
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is: SBO:0000176

metaM ser D e
initial amount: NaN
name: D-serine
type: Species
is: HMDB03406
is: CHEBI:16523
has only substance units: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false

metaR EX leugly LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylglycine
type: Reaction

metaR DOLP Lter
product: MODEL1310110055#
fast: false
reversible: false
is described by: ECO:0000000
name: dolichol phosphate flippase (liver)
kinetic law: MODEL1310110055#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110055#

metaM glutcoa c
type: Species
is: HMDB01339
initial concentration: 1.0
name: glutaryl-CoA(5-)
constant: false
has only substance units: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM mmcoa R m
has only substance units: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
is: SBO:0000247
name: (R)-methylmalonyl-CoA(5-)
is: CHEBI:57326
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB01269
type: Species
initial amount: NaN

metaR MTHFD2
is version of: http://identifiers.org/ec-code/3.5.4.9
reactant: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
modifier: MODEL1310110055#
type: Reaction
is described by: ECO:0000134
fast: false
name: methylenetetrahydrofolate dehydrogenase (NAD)
kinetic law: MODEL1310110055#
reversible: true
product: MODEL1310110055#

metaM gluside hs c
boundary condition: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial amount: NaN
has only substance units: false
is: CHEBI:18368
name: D-glucosyl-N-acylsphingosine
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR C81CPT1
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of ocetenoylcarnitine
type: Reaction

metaR AICART
is version of: http://identifiers.org/ec-code/2.1.2.3
type: Reaction
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
is described by: ECO:0000269
product: MODEL1310110055#
fast: false
reversible: true
kinetic law: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
modifier: MODEL1310110055#
name: phosphoribosylaminoimidazolecarboxamide formyltransferase

metaR ACGPID
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
reversible: false
kinetic law: MODEL1310110055#
type: Reaction
product: MODEL1310110055#
fast: false
modifier: MODEL1310110055#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.1.89
reactant: MODEL1310110055#
is: SBO:0000176
name: N-acetylglucosaminylphosphatidylinositol deacetylase

metaR r0650
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/4.1.1.36
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is: SBO:0000176
fast: false
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#
type: Reaction

metaR CORE3GTg
reversible: false
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110055#
fast: false
type: Reaction
product: MODEL1310110055#
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_fcc00b0b_330f_4502_8838_cd185f823566
initial concentration: NaN
name: ACAA1
is: Q96CA6
initial amount: NaN
is encoded by: hsa:30
type: Species
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM ksii core2 pre2 g
notes: FORMULA: C39H63N3O28X CHARGE: -1
has only substance units: false
is: CHEBI:58053
is: SBO:0000247
is: HMDB00175
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 2
type: Species
is: C00130
boundary condition: false
constant: false

metaM ser D c
name: D-serine
initial amount: NaN
is: CHEBI:16523
constant: false
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
initial concentration: 1.0
is: HMDB03406
is: SBO:0000247

metaM Rtotal e
is: CHEBI:3554
initial concentration: 1.0
constant: false
is: C00255
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00244
boundary condition: false
notes: FORMULA: CO2FULLR CHARGE: -1
type: Species
name: R total

metaM ptth c
has only substance units: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
boundary condition: false
is: CHEBI:16753
initial amount: NaN
is: HMDB03426
name: pantetheine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_d2cd4081_85bb_421d_b93e_86ad2a6b667e
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is: O15121
is encoded by: hsa:8560
has only substance units: false
name: DEGS1

metaR PETOHMm hs
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.1.17
fast: false
product: MODEL1310110055#
name: phosphatidylethanolamine N-methyltransferase
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
is: SBO:0000176
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000254
reactant: MODEL1310110055#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110055#_2c1b4f91_c706_4595_b7c8_6a21235f1796
has only substance units: false
is encoded by: hsa:5625
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is: O43272
name: PRODH
initial amount: NaN
boundary condition: true

metaM 4hpro LT c
has only substance units: false
name: trans-4-hydroxy-L-proline
is: CHEBI:18095
boundary condition: false
is: HMDB00725
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
initial concentration: 1.0

metaR r1381
product: MODEL1310110055#
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000176
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:

metaM o2s m
initial amount: NaN
constant: false
type: Species
is: CHEBI:18421
name: Superoxide anion
boundary condition: false
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial concentration: 1.0
has only substance units: false
is: HMDB02168
is: C00704
is: SBO:0000247

metaR r2017
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
reactant: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM Rtotal c
type: Species
is: CHEBI:16189
is: HMDB01448
name: R total
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: CO2FULLR CHARGE: -1
constant: false
boundary condition: false

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

metaR GLYCTDle
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
name: difussion of glycerol accross the brush border membrane
reactant: MODEL1310110055#
reversible: true
is: SBO:0000185
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000134
fast: false

metaR MM7Cbg
kinetic law: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.113
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
reversible: false
is: SBO:0000176
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
fast: false
reactant: MODEL1310110055#
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_8075ee76_ddc4_4324_80f6_55eae8550cc2
constant: false
is: O75251
is: SBO:0000252
is encoded by: hsa:374291
name: NDUFS7
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR XYLtly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reversible: false
reactant: MODEL1310110055#
name: Xylose efflux from lysosome
type: Reaction
kinetic law: MODEL1310110055#
fast: false
is: SBO:0000185
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_efdf8088_62bc_4451_ad5b_63c64a9c961f
initial concentration: NaN
type: Species
has only substance units: false
name: PDE8A
is: SBO:0000252
constant: false
is: O60658
is encoded by: hsa:5151
initial amount: NaN
boundary condition: true

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_61689419_e8ad_413f_aab1_7de222997f06
is: O00400
is: SBO:0000252
initial amount: NaN
name: SLC33A1
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9197
constant: false
has only substance units: false
type: Species

metaR S3TASE2ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
reversible: true
fast: false
is: SBO:0000176
kinetic law: MODEL1310110055#
name: N-acetylglucosamine-3-sulfatase, lysosomal
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110055#
product: MODEL1310110055#

metaM o2s n
is: HMDB02168
name: superoxide
initial amount: NaN
constant: false
type: Species
is: CHEBI:18421
has only substance units: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR B3GNT315g
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
product: MODEL1310110055#
fast: false
is described by: ECO:0000254
type: Reaction
modifier: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
reversible: false

metaR CYTK10
name: cytidylate kinase (CMP,dGTP)
product: MODEL1310110055#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110055#
modifier: MODEL1310110055#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
kinetic law: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR FUCASE2e
is: SBO:0000176
is described by: ECO:0000000
fast: false
modifier: MODEL1310110055#
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.51
type: Reaction
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:10460218,PMID:11389735,PMID:12604617,PMID:2317201 NOTES:NCD
reversible: false
name: alpha-fucosidase, extracellular

http://identifiers.org/biomodels.db/MODEL1310110055#_7ac30d00_a5f5_45b4_bd99_28fca551f6c2
has only substance units: false
name: SLC3A2
type: Species
initial amount: NaN
is encoded by: hsa:6520
constant: false
boundary condition: true
is: P08195
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_e713ae95_9786_4c55_81ec_5bbea35dc8e8
type: Species
boundary condition: true
name: B4GALT1
is: SBO:0000252
is: P15291
is encoded by: hsa:2683
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false

metaR CSNATm
is described by: ECO:0000269
reactant: MODEL1310110055#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
modifier: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.7
kinetic law: MODEL1310110055#
name: carnitine O-aceyltransferase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110055#_60562196_e2c3_4211_bdb5_9c1c8351cead
is: Q86UL3
is encoded by: hsa:137964
boundary condition: true
name: AGPAT6
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_1c4d526c_a633_45a2_9ab0_7d614f9304e7
initial amount: NaN
has only substance units: false
name: NDUFB8
boundary condition: true
type: Species
is encoded by: hsa:4714
is: O95169
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_65dfbbb8_5445_4df2_813f_dbb73f28e86a
name: FUT8
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:2530
is: SBO:0000252
initial amount: NaN
is: Q546E0
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_4a53ec8d_6b24_4cff_bbd1_9fed11e30900
has only substance units: false
boundary condition: true
is: O43678
name: NDUFA2
type: Species
initial amount: NaN
is encoded by: hsa:4695
is: SBO:0000252
constant: false
initial concentration: NaN

metaR PItg
product: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110055#
fast: false
name: phosphate transport, Golgi apparatus
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaM ocdececrn c
name: 11-octadecenoyl carnitine
is: SBO:0000247
boundary condition: false
is: HMDB06351
initial concentration: 1.0
notes: FORMULA: C25H47NO4 CHARGE: 0
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaR ATPS4m
type: Reaction
reactant: MODEL1310110055#
modifier: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.3.14
fast: false
name: ATP synthase (four protons for one ATP)
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.6.4.6
notes: GENE_ASSOCIATION: (513.1 and 498.2 and 506.1 and 509.2 and 514.1 or 498.2 and 513.2 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 514.2 and 506.1 or 498.2 and 513.2 and 506.1 and 509.2 and 514.1 or 513.2 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 498.1 and 506.1 and 509.2 and 514.1 or 513.1 and 498.2 and 514.2 and 506.1 and 509.2 or 513.1 and 498.2 and 509.1 and 506.1 and 514.1 or 498.2 and 509.1 and 513.2 and 506.1 and 514.1 or 513.2 and 498.1 and 506.1 and 509.2 and 514.1 or 513.2 and 514.2 and 506.1 and 509.2 and 498.3 or 513.2 and 506.1 and 509.2 and 498.3 and 514.1 or 513.1 and 509.1 and 506.1 and 498.3 and 514.1 or 509.1 and 513.2 and 514.2 and 506.1 and 498.3 or 513.1 and 498.2 and 509.1 and 514.2 and 506.1 or 513.1 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 506.1 and 514.1 or 513.1 and 506.1 and 509.2 and 498.3 and 514.1 or 509.1 and 513.2 and 506.1 and 498.3 and 514.1 or 513.1 and 514.2 and 506.1 and 509.2 and 498.3 or 509.1 and 513.2 and 498.1 and 506.1 and 514.1 or 513.1 and 509.1 and 514.2 and 506.1 and 498.3 or 498.2 and 509.1 and 513.2 and 514.2 and 506.1 or 509.1 and 513.2 and 498.1 and 514.2 and 506.1) and (10632.1 and 4905.1 and 10476.1 and 9551.3 and 522.5 and 516.2 and 521.1 and 515.1 or 518.3 and 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 9551.3 and 522.3 or 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 517.2 and 9551.2 and 522.3 or 10632.1 and 4905.1 and 10476.1 and 522.5 and 9551.2 and 518.2 and 521.1 and 515.1 or 4905.1 and 515.2 and 10476.2 and 516.2 and 521.1 and 10632.1 and 9551.3 and 522.5 or 518.3 and 4905.1 and 9551.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 522.4 or 10632.1 and 4905.1 and 10476.1 and 9551.1 and 522.2 and 515.2 and 518.2 and 521.1 or 518.3 and 10632.1 and 4905.1 and 10476.1 and 515.3 and 9551.2 and 522.4 and 521.1 or 10632.1 and 4905.1 and 10476.1 and 515.3 and 522.2 and 9551.3 and 518.2 and 521.1 or 4905.1 and 9551.1 and 10476.2 and 522…
reversible: false
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.6.1.14

http://identifiers.org/biomodels.db/MODEL1310110055#_32c27065_fae1_43a1_82eb_a0ada059f97f
initial concentration: NaN
is: SBO:0000252
is: O60312
constant: false
boundary condition: true
is encoded by: hsa:57194
initial amount: NaN
has only substance units: false
name: ATP10A
type: Species

metaR CYTK11
reversible: true
name: cytidylate kinase (dCMP,dGTP)
product: MODEL1310110055#
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110055#
is: SBO:0000176

metaR r0655
reversible: true
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
kinetic law: MODEL1310110055#
product: MODEL1310110055#
modifier: MODEL1310110055#
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
is: SBO:0000176
reactant: MODEL1310110055#
fast: false

metaM n2m2nmasn e
is: C04946
notes: FORMULA: C58H96N5O40X CHARGE: 0
type: Species
constant: false
initial concentration: 1.0
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_9986aa89_49e9_4fca_9897_450639311f88
is encoded by: hsa:7991
name: TUSC3
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252

metaR ALADGLNexR
product: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000304
kinetic law: MODEL1310110055#
reversible: true
type: Reaction
name: L-alanine/glutamine reversible exchange

metaM lald D c
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
has only substance units: false
is: HMDB06458
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:17167
constant: false
initial concentration: 1.0
boundary condition: false
name: (R)-lactaldehyde

http://identifiers.org/biomodels.db/MODEL1310110055#_8adcd822_9811_45fd_be12_c0ab4fb25a76
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is: O14734
is encoded by: hsa:10005
is: SBO:0000252
boundary condition: true
name: ACOT8
type: Species

metaR TRPt
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
product: MODEL1310110055#
fast: false
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
name: L-tryptophan transport
is described by: ECO:0000269
modifier: MODEL1310110055#

metaM subeac c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C8H12O4 CHARGE: -2
type: Species
name: suberic acid
is: HMDB00893
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR r1384
fast: false
name: Guanosine aminohydrolase EC:3.5.4.15
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110055#
product: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
is: SBO:0000176

metaM dd3coa x
has only substance units: false
constant: false
name: 3-dodecenoylcoa
initial concentration: 1.0
is: HMDB04257
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
boundary condition: false

metaR CSNATp
kinetic law: MODEL1310110055#
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
fast: false
reactant: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.7
reversible: true
is: SBO:0000176
modifier: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_dab4d68a_5d98_48b2_a1f3_d898ea7a0292
is: Q8NCG5
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
is encoded by: hsa:10164
is: SBO:0000252
name: CHST4
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_378f8f34_79a5_4815_86c1_16c26fef83a7
initial amount: NaN
name: SULT1A1
has only substance units: false
is encoded by: hsa:6817
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species

metaR CYTK12
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
name: cytidylate kinase (dCMP,dCTP)
product: MODEL1310110055#
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000176
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true

metaR FAOXC12C12OHm
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->OHC12)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_metaM_fucgalacgalfucgalacglcgal14acglcgalgluside_hs_g
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)2 (Cer)1
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:61648
initial amount: NaN

metaR FAOXC225C226x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

metaR MECOALm
is version of: http://identifiers.org/ec-code/6.2.1.5
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/6.2.1.4
reactant: MODEL1310110055#
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
reversible: true
modifier: MODEL1310110055#
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110055#

metaR r2014
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110055#
fast: false
modifier: MODEL1310110055#
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction

metaR r1627
kinetic law: MODEL1310110055#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110055#
product: MODEL1310110055#

metaR CYTK3
type: Reaction
reactant: MODEL1310110055#
is described by: ECO:0000269
name: cytidylate kinase (CMP)(GTP)
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
product: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_de143aeb_6a7f_438b_ae07_3bd0b383fb0c
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
name: SLC23A2
has only substance units: false
is encoded by: hsa:9962

metaM ivcrn c
name: isovaleryl carnitine
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: HMDB00688
notes: FORMULA: C12H23NO4 CHARGE: 0
initial concentration: 1.0
boundary condition: false

metaM adrncoa c
has only substance units: false
name: adrenyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205480
is: C16170
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_f8a9dbfb_9557_4cf8_90f1_e664c4989d60
is: SBO:0000252
is encoded by: hsa:AL048840
initial concentration: NaN
name: _AL048840_1_c
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
constant: false

metaR EX galacglcgalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Gal-GlcNAc-Gal globoside (homo sapiens) exchange
type: Reaction

metaM anth c
initial amount: NaN
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
is: HMDB01123
is: CHEBI:16567
boundary condition: false
initial concentration: 1.0
name: anthranilate
is: SBO:0000247
type: Species
has only substance units: false
constant: false

metaM ahdt e
is: HMDB00980
notes: FORMULA: C9H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C9H16N5O13P3/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-25-29(21,22)27-30(23,24)26-28(18,19)20/h4,6,15-16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,10,11,13,14,17)/p-4/t4-,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01367 EHMN_ABBREVIATION: C04895
name: 7,8-dihydroneopterin 3'-triphosphate(4-)
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:58462
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_b3def9e5_919a_44b7_ac81_a0d9f604a76d
initial amount: NaN
constant: false
is: SBO:0000252
name: CMPK1
is encoded by: hsa:51727
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: B2R6S5

metaR B3GNT314g
is described by: ECO:0000254
modifier: MODEL1310110055#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
kinetic law: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
type: Reaction
product: MODEL1310110055#
is: SBO:0000176
reversible: false
reactant: MODEL1310110055#

metaM hexdiac c
is: HMDB00672
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C16H28O4 CHARGE: -2
is: C08260
is: SBO:0000247
name: hexadecanediocacid
has only substance units: false
type: Species
boundary condition: false
constant: false

metaM m3mpdol L c
has only substance units: false
is: CHEBI:37632
initial amount: NaN
type: Species
boundary condition: false
constant: false
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human liver homolog
notes: FORMULA: C1480H2428N20O370P20 CHARGE: -20
is: SBO:0000247
initial concentration: 1.0

metaR CSEPASEly
is: SBO:0000176
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110055#
product: MODEL1310110055#
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
reversible: false

metaR MI4PP
fast: false
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.1.3.25
reversible: false
type: Reaction
name: myo-inositol 4-phosphatase
product: MODEL1310110055#
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110055#_2bcac838_5d94_4a70_a6a5_432ca42adb60
is: SBO:0000252
has only substance units: false
is encoded by: hsa:55350
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
name: VNN3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_497ccbff_ef29_42d1_adb0_2e918886fc8e
has only substance units: false
is encoded by: hsa:8671
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: SLC4A4
is: A5JJ20

metaR CYTK4
name: cytidylate kinase (dCMP)(GTP)
type: Reaction
modifier: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
product: MODEL1310110055#
reversible: true
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000269

metaR r1626
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: true
type: Reaction
fast: false

metaM pristcoa x
is: CHEBI:51341
type: Species
constant: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
initial amount: NaN
name: pristanoyl coa
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR TKT1
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
name: transketolase
product: MODEL1310110055#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.2.1.1
fast: false
type: Reaction

metaR SUCCOAPET
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaM h2o2 m
type: Species
is: HMDB03125
name: Hydrogen peroxide
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: C00027
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: CHEBI:16240

http://identifiers.org/biomodels.db/MODEL1310110055#_58f033fb_aa8e_4a6f_8435_b26ce67aae13
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:2936
initial concentration: NaN
is: P00390
name: GSR
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_d1a29708_7dc1_405f_a734_3309e3837ad2
name: _AI601100_1_m
has only substance units: false
boundary condition: true
is encoded by: hsa:AI601100
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species

metaR GGH 6DHFe
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
name: Gamma-glutamyl hydrolase (6DHF), extracellular
is described by: ECO:0000000
is: SBO:0000176
fast: false
modifier: MODEL1310110055#
reversible: false
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9

metaR FACOAL184
name: fatty-acid--CoA ligase
reversible: true
fast: false
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110055#
type: Reaction
product: MODEL1310110055#

metaR RE3074X
is: SBO:0000176
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: RE3074
product: MODEL1310110055#
reversible: true
type: Reaction
modifier: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:11060359,PMID:11356164 NOTES:IT - fixed proton
is described by: ECO:0000000
fast: false

metaM c4dc c
is: http://identifiers.org/pubchem.compound/213144
initial concentration: 1.0
name: succinyl carnitine
constant: false
is: C02862
boundary condition: false
is: SBO:0000247
notes: FORMULA: C11H18NO6 CHARGE: -1
has only substance units: false
initial amount: NaN
is: HMDB02013
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_e9030ee8_98e6_485a_bb86_a79813d10ad0
is encoded by: hsa:84720
is: Q8TEQ8
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
name: PIGO
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_2873a56c_12e5_4fce_921b_a65ca0e0b936
is: Q9NRZ7
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:56894
initial amount: NaN
name: AGPAT3
has only substance units: false
is: SBO:0000252
type: Species

metaM 4hpro LT m
type: Species
boundary condition: false
is: HMDB00725
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: trans-4-hydroxy-L-proline
is: CHEBI:18095
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_120dde97_dbe3_4fe1_bdea_b4bdc463db26
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
name: SQLE
is: Q5HYI4
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6713

metaR r1625
reactant: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
product: MODEL1310110055#

metaR r0149
kinetic law: MODEL1310110055#
is: SBO:0000176
modifier: MODEL1310110055#
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
type: Reaction
fast: false
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.39
reversible: true
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

metaR FAOXC164C163x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)x
type: Reaction

metaR r0527
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
fast: false
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
is: SBO:0000176
product: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#

metaR CITL
kinetic law: MODEL1310110055#
is described by: ECO:0000000
modifier: MODEL1310110055#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
reactant: MODEL1310110055#
reversible: false
fast: false
name: Citrate lyase
product: MODEL1310110055#

metaM ptth m
boundary condition: false
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
constant: false
is: HMDB03426
initial amount: NaN
is: SBO:0000247
name: pantetheine
type: Species
initial concentration: 1.0
is: CHEBI:16753
has only substance units: false

metaM ivcrn e
initial amount: NaN
constant: false
is: SBO:0000247
name: isovaleryl carnitine
type: Species
is: HMDB00688
has only substance units: false
notes: FORMULA: C12H23NO4 CHARGE: 0
initial concentration: 1.0
boundary condition: false

metaM h2o2 n
constant: false
is: SBO:0000247
is: HMDB03125
initial concentration: 1.0
name: hydrogen peroxide
is: CHEBI:16240
has only substance units: false
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_5c11e551_4922_4f09_b6f5_d82971ede71c
boundary condition: true
initial amount: NaN
name: NDUFB4
is encoded by: hsa:4710
initial concentration: NaN
type: Species
is: O95168
is: SBO:0000252
has only substance units: false
constant: false

metaM dgsn m
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: HMDB00085
constant: false
type: Species
name: Deoxyguanosine
is: CHEBI:17172
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: C00330

http://identifiers.org/biomodels.db/MODEL1310110055#_6f706b94_5bf9_4196_bd23_fe332b4351f5
is: SBO:0000252
is encoded by: hsa:6483
is: Q16842
initial amount: NaN
name: ST3GAL2
boundary condition: true
constant: false
initial concentration: NaN
type: Species
has only substance units: false

metaM anth e
is: HMDB01123
is: CHEBI:16567
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
name: anthranilate
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
constant: false
has only substance units: false
initial amount: NaN

metaR FAOXC161C161OHm
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of 3-hydroxyhexadecenoylcoA
type: Reaction

metaR CYTK2
reactant: MODEL1310110055#
is described by: ECO:0000269
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110055#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110055#
reversible: true
name: cytidylate kinase (dCMP)

metaR r1624
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110055#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
is described by: ECO:0000000
fast: false

metaR FBA
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
reversible: true
is version of: http://identifiers.org/ec-code/4.1.2.13
fast: false
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
product: MODEL1310110055#
name: fructose-bisphosphate aldolase
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_c68af483_0109_47c4_a360_62e533bf6685
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110055#_b9504722_2757_488b_95bc_3a225453d32e
initial amount: NaN
type: Species
is encoded by: hsa:6611
constant: false
is: SBO:0000252
name: SMS
is: P52788
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_ee8d2137_3779_43de_9873_89fa9c6ae870
boundary condition: true
type: Species
name: DPM1
is: SBO:0000252
is encoded by: hsa:8813
has only substance units: false
constant: false
is: O60762
initial concentration: NaN
initial amount: NaN

metaM 5dpmev c
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1
boundary condition: false
initial amount: NaN
constant: false
is: HMDB01090
type: Species
name: (R)-5-Diphosphomevalonate

metaM hexdectecoa x
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
name: 2,4,7,10-hexadecatetraenoylcoa
type: Species
is: HMDB02288
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaM nadh x
constant: false
is: http://identifiers.org/pubchem.compound/3306
is: C00004
is: SBO:0000247
is: CHEBI:57945
initial concentration: 1.0
has only substance units: false
name: Nicotinamide adenine dinucleotide - reduced
is: HMDB01487
type: Species
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_0311a324_7390_46cb_bff1_e7c75c40baa0
name: ACADL
boundary condition: true
is encoded by: hsa:33
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is: P28330

metaM ach n
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial amount: NaN
type: Species
is: CHEBI:15355
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00895
has only substance units: false
initial concentration: 1.0
name: acetylcholine

metaR CYTK1
name: cytidylate kinase (CMP)
modifier: MODEL1310110055#
is described by: ECO:0000269
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110055#
fast: false
product: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110055#_8521b055_b840_4b64_8556_6b1291c3b473
has only substance units: false
type: Species
is encoded by: hsa:AA532636
name: _AA532636_1_m
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN

metaR NTD7e
is version of: http://identifiers.org/ec-code/3.1.3.5
product: MODEL1310110055#
fast: false
type: Reaction
kinetic law: MODEL1310110055#
reversible: false
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:14578500 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reactant: MODEL1310110055#
modifier: MODEL1310110055#
name: 5'-nucleotidase (AMP), extracellular

metaR DHEAtr
fast: false
reversible: true
name: Dehydroepiandrosterone transport
is: SBO:0000185
product: MODEL1310110055#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.8.2.2 Confidence Level: 1 AUTHORS: PMID:11535246,PMID:1588921 NOTES:

metaR DDECE1CRNe
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of dodecenoyl carnitine into extra cellular space
type: Reaction

metaR GHMT2r
product: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.1.2.1
kinetic law: MODEL1310110055#
name: glycine hydroxymethyltransferase, reversible
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
is: SBO:0000176
fast: false
is described by: ECO:0000269
reversible: true

metaR r0525
reversible: true
name: N6-(L-1,3-Dicarboxypropyl)-L-lysine:NAD+ oxidoreductase; N6-(L-1,3-Dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming) Lysine degradation EC:1.5.1.9
fast: false
is: SBO:0000176
product: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.9 Confidence Level: 0 AUTHORS: PMID:235294,PMID:4774398 NOTES:
reactant: MODEL1310110055#

metaM dcdp m
initial amount: NaN
is: SBO:0000247
name: dCDP(3-)
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
type: Species
initial concentration: 1.0
is: HMDB01245
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:58593

http://identifiers.org/biomodels.db/MODEL1310110055#_ca472ae2_3d5e_421b_8bf1_e4e1e3ee9388
is: Q9Y6L6
boundary condition: true
has only substance units: false
is encoded by: hsa:10599
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
name: SLCO1B1

metaM leuktrB4 e
initial concentration: 1.0
name: leukotriene B4(1-)
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: HMDB01085
boundary condition: false
is: CHEBI:57461
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165

http://identifiers.org/biomodels.db/MODEL1310110055#_85e9749f_22bf_4921_a468_b9959a0744e4
constant: false
name: AFMID
is: SBO:0000252
type: Species
is encoded by: hsa:125061
initial amount: NaN
is: Q63HM1
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM camp c
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
has only substance units: false
name: 3',5'-cyclic AMP(1-)
constant: false
is: CHEBI:58165
is: HMDB00058
boundary condition: false

metaM 3hibutcoa m
has only substance units: false
name: (S)-3-Hydroxyisobutyryl-CoA
type: Species
constant: false
boundary condition: false
is: HMDB01052
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
is: CHEBI:28259

metaR DHCR72r
name: 7-dehydrocholesterol reductase
product: MODEL1310110055#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.21
type: Reaction
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
reactant: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_2cfca83b_1144_4ada_b5d1_d5df6503326d
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: CDA
is: P32320
constant: false
is encoded by: hsa:978
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_6b1745b4_79bb_4cb0_9d06_575798b7a701
is: E5KNH5
boundary condition: true
is encoded by: hsa:4723
constant: false
name: NDUFV1
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN

metaM ha pre1 l
has only substance units: false
is: CHEBI:16126
is: SBO:0000247
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
name: hyaluronan biosynthesis, precursor 1

metaR OCD11CRNCPT2
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaM tre e
has only substance units: false
name: Trehalose
type: Species
is: C01083
is: CHEBI:16551
constant: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
is: HMDB00975
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaM dcdp n
is: CHEBI:58593
has only substance units: false
initial amount: NaN
is: HMDB01245
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
name: dCDP(3-)
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaR r0413
fast: false
reversible: false
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reactant: MODEL1310110055#
name: dATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
product: MODEL1310110055#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_5720b6b3_01c9_4453_bae3_7c4dba1345f2
is: SBO:0000252
is encoded by: hsa:79143
is: Q96N66
constant: false
name: MBOAT7
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_117b5ca1_7e67_48a1_abbf_0cad03c49082
boundary condition: true
has only substance units: false
initial concentration: NaN
name: GALE
is: SBO:0000252
constant: false
type: Species
is: Q14376
is encoded by: hsa:2582
initial amount: NaN

metaM ru5p D c
is: SBO:0000247
has only substance units: false
is: HMDB00618
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
name: D-ribulose 5-phosphate(2-)
is: CHEBI:58121
type: Species
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188

metaM succoa m
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
initial amount: NaN
name: Succinyl-CoA
is: HMDB01022
is: CHEBI:57292

metaM tag hs e
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
name: triglyceride
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
is: CHEBI:17855
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_ad2c1a24_8dec_4b4a_ac68_f92bcc63d2b1
is encoded by: hsa:10637
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: O75610
name: LEFTY1
type: Species
initial concentration: NaN
is: SBO:0000252

metaR FRUt4
name: D-fructose transport via sodium cotransport
reactant: MODEL1310110055#
is described by: ECO:0000269
product: MODEL1310110055#
modifier: MODEL1310110055#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
fast: false
kinetic law: MODEL1310110055#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_0046ee99_2953_4a56_a471_d154e8117d3d
initial amount: NaN
name: ALDH3B1
is encoded by: hsa:221
boundary condition: true
is: SBO:0000252
is: P43353
constant: false
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_09a2df5a_1244_4906_adee_89f352ff5d98
name: PIP5K1A
is: Q99755
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:8394
type: Species

metaM cholcoar x
boundary condition: false
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
constant: false
is: SBO:0000247
is: CHEBI:58677
initial concentration: 1.0
type: Species
is: HMDB02178
has only substance units: false
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_9c5f7c7f_ab54_4548_85a0_701ababd7bee
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:10723
is: SBO:0000252
boundary condition: true
is: Q9Y666
name: SLC12A7

http://identifiers.org/biomodels.db/MODEL1310110055#_f2366da5_b5ea_435c_85b2_29fa4a0ab844
boundary condition: true
is encoded by: hsa:8801
has part: P53597
name: SUCLG2:SUCLG1
is: SBO:0000297
is encoded by: hsa:8802
type: Species
has part: Q96I99
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN

metaR r1629
product: MODEL1310110055#
is: SBO:0000185
reactant: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_7888a5df_abba_4581_a80a_1b4021fb1131
is: O60427
initial concentration: NaN
type: Species
is encoded by: hsa:3992
constant: false
boundary condition: true
name: FADS1
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR TKT2
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.2.1.1
kinetic law: MODEL1310110055#
product: MODEL1310110055#
name: transketolase
type: Reaction
modifier: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2

metaR r0410
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110055#
product: MODEL1310110055#
reversible: true
kinetic law: MODEL1310110055#
fast: false
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19

metaR r0523
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
product: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#

metaR CRNt
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110055#
fast: false
is: SBO:0000185
name: L-carnitine reversible transport
reversible: true
type: Reaction
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_27129413_2dbb_46de_9816_18231e5fb049
is: P25705
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:498
boundary condition: true
type: Species
name: ATP5A1
is: SBO:0000252

metaR PRGNLONEtm
reversible: true
fast: false
reactant: MODEL1310110055#
name: pregnenolone intracellular transport
kinetic law: MODEL1310110055#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ

metaR r0145
product: MODEL1310110055#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
is version of: http://identifiers.org/ec-code/1.8.3.1
is described by: ECO:0000000
type: Reaction
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
fast: false
modifier: MODEL1310110055#

metaM leuktrB4 c
constant: false
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: CHEBI:57461
name: leukotriene B4(1-)
has only substance units: false
is: SBO:0000247
is: HMDB01085
initial amount: NaN
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_7bfcef81_cc8b_4593_b99a_9127b61f412b
boundary condition: true
name: SLC7A5
is: Q8IV97
type: Species
is encoded by: hsa:8140
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR r1628
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110055#
is: SBO:0000185
reactant: MODEL1310110055#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_b7f559ad_88cb_4a08_982b_0e690c892d61
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:8659
is: P30038
boundary condition: true
has only substance units: false
constant: false
name: ALDH4A1

metaM octdececoa m
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
name: octadecenoylcoa
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355

http://identifiers.org/biomodels.db/MODEL1310110055#_237dbc43_c882_4c0b_b316_5675df8ca8eb
name: AK1
type: Species
initial concentration: NaN
constant: false
is: P00568
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:203
initial amount: NaN

metaR TRPHYDRO2
reactant: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110055#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
is version of: http://identifiers.org/ec-code/1.14.16.4
is described by: ECO:0000269
modifier: MODEL1310110055#
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)

metaR RE3628M
is version of: http://identifiers.org/ec-code/5.3.3.8
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is: SBO:0000176
reactant: MODEL1310110055#
type: Reaction
reversible: true
product: MODEL1310110055#
name: RE3628
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false

metaM hdcoa c
type: Species
has only substance units: false
is: SBO:0000247
name: Hexadecenoyl-CoA (n-C16:1CoA)
initial concentration: 1.0
constant: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
is: HMDB06532

metaM tag hs c
type: Species
name: triglyceride
initial amount: NaN
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
is: SBO:0000247
constant: false
is: CHEBI:17855
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM ach e
has only substance units: false
is: CHEBI:15355
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: HMDB00895
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
name: acetylcholine
initial concentration: 1.0
boundary condition: false

metaM h2o2 c
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: HMDB03125
is: CHEBI:16240
constant: false
name: Hydrogen peroxide
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial amount: NaN
is: C00027
is: SBO:0000247

metaM hpdca c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
name: margarate
boundary condition: false
is: HMDB02259
initial amount: NaN
initial concentration: 1.0
is: CHEBI:32366
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_76f79702_70ea_4ea7_bb78_842f3ff44147
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:AA081045
name: _AA081045_1_e
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_56e01aba_543c_4d50_ac44_e50c378e1cff
boundary condition: true
name: DGKZ
initial amount: NaN
is: G3V0F6
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8525
is: SBO:0000252

metaR r2311
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110055#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_443ea074_4d56_44b6_9669_3bcfd2394e98
constant: false
has only substance units: false
is encoded by: hsa:AA614647
is: SBO:0000252
initial concentration: NaN
name: _AA614647_1_c
initial amount: NaN
type: Species
boundary condition: true

metaM dgsn c
initial amount: NaN
boundary condition: false
is: HMDB00085
is: C00330
is: CHEBI:17172
type: Species
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: Deoxyguanosine

http://identifiers.org/biomodels.db/MODEL1310110055#_9c7cd214_0697_47cb_a493_018f3753a153
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: B2RDZ2
name: RFK
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:55312
constant: false

metaR FAOXC102C101x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:1)x
type: Reaction

metaR ACITL
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
reactant: MODEL1310110055#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.3.3.8
is described by: ECO:0000000
fast: false
name: ATP-Citrate lyase
is: SBO:0000176
product: MODEL1310110055#
kinetic law: MODEL1310110055#

metaR KYNAKGAT
reversible: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.7
is: SBO:0000176
modifier: MODEL1310110055#
fast: false
name: L-Kynurenine:2-oxoglutarate aminotransferase
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.6.1.64
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110055#_60d7dca4_ab69_46bc_b384_20242186c134
name: _R51273_1_c
boundary condition: true
has only substance units: false
is encoded by: hsa:R51273
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_66e5cf94_12e7_4abc_9286_bf4b48c8145b
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10861
name: SLC26A1
is: Q9H2B4
initial amount: NaN
constant: false
boundary condition: true

metaR r2312
product: MODEL1310110055#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_9bc5fdb0_d233_4044_b670_e943273d3676
initial amount: NaN
boundary condition: true
constant: false
name: TM7SF2
is: SBO:0000252
type: Species
has only substance units: false
is: O76062
is encoded by: hsa:7108
initial concentration: NaN

metaR r0522
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
kinetic law: MODEL1310110055#
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
reversible: false
reactant: MODEL1310110055#
modifier: MODEL1310110055#
is: SBO:0000176
fast: false
product: MODEL1310110055#
type: Reaction
is described by: ECO:0000000

metaR MEVK1c
is version of: http://identifiers.org/ec-code/2.7.1.36
type: Reaction
reversible: false
reactant: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
is: SBO:0000176
name: mevalonate kinase (atp) cytosol
fast: false
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000134

metaM xan c
boundary condition: false
initial amount: NaN
is: C00385
is: HMDB00292
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: SBO:0000247
name: Xanthine
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
is: CHEBI:17712

metaM nad x
is: SBO:0000247
is: HMDB00902
constant: false
type: Species
is: CHEBI:57540
initial concentration: 1.0
boundary condition: false
is: C00003
name: Nicotinamide adenine dinucleotide
is: http://identifiers.org/pubchem.compound/3305
has only substance units: false
initial amount: NaN

metaM hpdca e
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB02259
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
boundary condition: false
name: margarate
is: CHEBI:32366
initial concentration: 1.0
type: Species
constant: false

metaM h2o2 e
initial concentration: 1.0
type: Species
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125
is: CHEBI:16240
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
name: hydrogen peroxide
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_706f3cf2_fa92_4901_9fc6_788196ad9808
is: P06132
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:7389
name: UROD
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_02290913_249c_49d4_bd1d_0115ebeb0b42
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
constant: false
name: AOC2
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:314

http://identifiers.org/biomodels.db/MODEL1310110055#_metaR_GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEtg
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
reversible: true
type: Reaction
kinetic law: MODEL1310110055#
is: SBO:0000185
reactant: MODEL1310110055#
is described by: ECO:0000000
name: blood group intracellular transport
product: MODEL1310110055#

metaR B3GNT32g
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
product: MODEL1310110055#
fast: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110055#
modifier: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR ECOAH9m
is described by: ECO:0000304
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
fast: false
modifier: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110055#_6a2b509d_ea79_437f_b9f7_d551c8e1efbc
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q9NY65
has only substance units: false
constant: false
is encoded by: hsa:1962
type: Species
initial amount: NaN
name: EHHADH

metaM ha pre1 e
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
has only substance units: false
type: Species
constant: false
is: CHEBI:16126
is: SBO:0000247
boundary condition: false
name: hyaluronan biosynthesis, precursor 1
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_790abf0e_f201_43d2_842b_056eefd9efff
type: Species
is encoded by: hsa:T83654
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: _T83654_1_m
initial amount: NaN
has only substance units: false

metaM gt3 hs g
notes: FORMULA: C63H104N4O36FULLRCO CHARGE: -3
boundary condition: false
is: CHEBI:28424
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: GT3
constant: false
type: Species

metaR CYTK9
type: Reaction
reactant: MODEL1310110055#
is described by: ECO:0000269
reversible: true
product: MODEL1310110055#
is: SBO:0000176
name: cytidylate kinase (CMP,dCTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110055#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_095bc2a8_99dc_449d_b885_25c8dd52fae2
is: P28331
initial concentration: NaN
constant: false
name: NDUFS1
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4719

http://identifiers.org/biomodels.db/MODEL1310110055#_88c8a202_4daf_4947_9db7_796570c492ef
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
name: NME1:NME2
is: SBO:0000297
constant: false
is encoded by: hsa:4830

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaM ocdececrn m
constant: false
is: SBO:0000247
initial concentration: 1.0
name: 11-octadecenoyl carnitine
type: Species
notes: FORMULA: C25H47NO4 CHARGE: 0
initial amount: NaN
is: HMDB06351
boundary condition: false
has only substance units: false

metaM dcdp c
is: SBO:0000247
has only substance units: false
constant: false
type: Species
name: dCDP
is: C00705
initial amount: NaN
is: HMDB01245
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: CHEBI:58593
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_95e4b1c8_683a_4218_b55b_22a553d13e19
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:6487
name: ST3GAL3
has only substance units: false
initial amount: NaN
type: Species

metaM 4hoxpacd c
initial concentration: 1.0
name: (4-hydroxyphenyl)acetaldehyde
is: HMDB03767
boundary condition: false
constant: false
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
is: CHEBI:15621
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN

metaM HC01223 m
is: CHEBI:57340
boundary condition: false
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247

metaR r0142
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reactant: MODEL1310110055#
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
type: Reaction
reversible: false

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

metaR r2310
product: MODEL1310110055#
reactant: MODEL1310110055#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110055#

metaM 5thf e
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB06487
constant: false
boundary condition: false
is: SBO:0000247
name: pentaglutamyl folate (THF)
has only substance units: false
notes: FORMULA: C39H45N11O18 CHARGE: -6

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaR UROLACer
reversible: true
is described by: ECO:0000000
name: uronolactonase, endoplasmic reticulum
kinetic law: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.19 Confidence Level: 1 AUTHORS: PMID:13587494 NOTES:NCD
fast: false
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_968bf822_b0b3_4239_b597_d98c64d6e0a0
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
name: HSD3B1
constant: false
is encoded by: hsa:3283
initial concentration: NaN
is: P14060
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_5cea6c38_5d87_4c87_b4d9_245b84965179
has only substance units: false
is encoded by: hsa:514
is encoded by: hsa:506
is encoded by: hsa:498
has part: P56381
has part: P36542
is encoded by: hsa:509
has part: P06576
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
type: Species
initial amount: NaN
is: SBO:0000297
has part: P30049
is encoded by: hsa:513
constant: false
has part: A8K092
initial concentration: NaN
boundary condition: true

metaR r2315
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110055#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110055#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110055#

metaR UGLT
reactant: MODEL1310110055#
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.7.12
modifier: MODEL1310110055#
reversible: true
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: UDPglucose--hexose-1-phosphate uridylyltransferase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_37ccf4be_72a3_40d6_9adf_f94f26cfef6e
initial amount: NaN
boundary condition: true
is: Q15181
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: PPA1
is encoded by: hsa:5464
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_94fe964e_3b74_4332_a18d_9adc3e0dd74f
has only substance units: false
initial amount: NaN
name: GART
type: Species
is: SBO:0000252
is: P22102
is encoded by: hsa:2618
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_30a3a365_d335_47ed_939e_d2ffd9f88a31
boundary condition: true
name: PFKFB1
is: SBO:0000252
is encoded by: hsa:5207
constant: false
is: P16118
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR ATPH1e
modifier: MODEL1310110055#
is: SBO:0000176
kinetic law: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.6.1.5
is version of: http://identifiers.org/ec-code/3.6.1.6
reversible: false
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (954.1) or (954.2) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
type: Reaction
is described by: ECO:0000269
name: ATP diphosphohydrolase

metaR ALCD21 D
is version of: http://identifiers.org/ec-code/1.1.1.1
name: alcohol dehydrogenase (D-1,2-propanediol)
fast: false
is: SBO:0000176
is described by: ECO:0000304
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
reactant: MODEL1310110055#
type: Reaction
product: MODEL1310110055#
modifier: MODEL1310110055#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.99.24

metaM 3mox4hpac m
is: HMDB05175
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
is: CHEBI:28111
type: Species
boundary condition: false
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde

metaR CYANtm
product: MODEL1310110055#
is: SBO:0000185
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
type: Reaction
name: Cyanide transport via diffusion (mitochondrial)
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110055#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_3246caee_4305_4271_ac43_2c24ec3dc8d8
constant: false
type: Species
is: P00491
is encoded by: hsa:4860
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: PNP

metaR CYTK7
fast: false
reversible: true
product: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
is described by: ECO:0000269
name: cytidylate kinase (CMP,UTP)
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110055#
type: Reaction

metaR THMTPt
kinetic law: MODEL1310110055#
name: Thiamine triphosphate transport in via anion antiport
product: MODEL1310110055#
is described by: ECO:0000269
reversible: false
fast: false
modifier: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (6573.1) or (6573.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10542220,PMID:14770311 NOTES:IT
reactant: MODEL1310110055#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_20add99f_04b1_4445_85d9_364fc79d02e0
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5294
constant: false
is: P48736
name: PIK3CG
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_abfb9857_9ba8_4709_8d73_6b0c72516f03
boundary condition: true
is: O00400
is: SBO:0000252
name: SLC33A1
type: Species
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:9197
initial concentration: NaN

metaR C181CPT1
product: MODEL1310110055#
name: transport of Octadecenoyl-CoA into mitochondrial matrix
reversible: false
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
type: Reaction
modifier: MODEL1310110055#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110055#
is: SBO:0000176

metaR r1623
modifier: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110055#
is described by: ECO:0000000
kinetic law: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110055#
fast: false
reversible: true

metaR 2OXOADOXm
is version of: http://identifiers.org/ec-code/1.8.1.4
reactant: MODEL1310110055#
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
reversible: false
product: MODEL1310110055#
is described by: ECO:0000304
fast: false
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.61
is version of: http://identifiers.org/ec-code/1.2.4.2
type: Reaction
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#

metaR r2316
reactant: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
product: MODEL1310110055#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110055#
fast: false

metaR RE3050R
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
type: Reaction
name: RE3050
product: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000176

metaM dhlpro m
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: H2S2X CHARGE: 0 EHMN_ABBREVIATION: C02972
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16194
name: Dihydrolipolprotein
constant: false

metaR THFt2
is: SBO:0000185
reversible: true
modifier: MODEL1310110055#
product: MODEL1310110055#
name: tetrahydrofolate transport via anion exchange
is described by: ECO:0000269
kinetic law: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (6573.1) or (6573.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:14770311 NOTES:IT
fast: false

metaR PItx
type: Reaction
reactant: MODEL1310110055#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: Phosphate transporter, peroxisome
fast: false

metaM nmn c
has only substance units: false
initial amount: NaN
is: HMDB00229
is: C00455
type: Species
boundary condition: false
is: SBO:0000247
name: NMN
initial concentration: 1.0
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
constant: false
is: CHEBI:14649

metaM L2aadp c
is: SBO:0000247
name: L-2-aminoadipate(1-)
initial concentration: 1.0
is: HMDB00510
has only substance units: false
type: Species
boundary condition: false
constant: false
is: CHEBI:58672
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
initial amount: NaN

metaM udpacgal l
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:57847
name: UDP-N-acetyl-D-galactosamine(2-)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: HMDB00304
type: Species
is: SBO:0000247

metaM nadh r
is: SBO:0000247
constant: false
is: CHEBI:57945
name: NADH(2-)
type: Species
is: HMDB01487
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM lgnc e
has only substance units: false
constant: false
name: lignocerate
initial concentration: 1.0
is: CHEBI:31014
is: SBO:0000247
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
boundary condition: false
is: HMDB02003
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_8f0f406b_af07_4583_ad3b_700fc80ee6f7
constant: false
is: SBO:0000252
is encoded by: hsa:BF195998
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
name: _BF195998_1_x

http://identifiers.org/biomodels.db/MODEL1310110055#_4037c9fb_0fc6_438c_a65d_c1404813cd86
is encoded by: hsa:89874
has only substance units: false
type: Species
initial amount: NaN
is: G3V4L5
name: SLC25A21
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN

metaR ALAGLNNaEx
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-alanine/L-glutamine Na-dependent exchange (Ala-L in)
type: Reaction
product: MODEL1310110055#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_2c0e07f4_a313_4a19_8dab_4a7f8c6afa3b
has only substance units: false
is: SBO:0000252
type: Species
name: HADHA
is encoded by: hsa:3030
initial concentration: NaN
initial amount: NaN
is: E9KL44
boundary condition: true
constant: false

metaR r1622
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110055#
reversible: true
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110055#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR CYTK8
product: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
name: cytidylate kinase (CMP,dATP)
reactant: MODEL1310110055#
is described by: ECO:0000269

metaR S6T9g
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110055#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110055#
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
type: Reaction
reversible: false

metaR C181CPT2
type: Reaction
modifier: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#
reversible: false
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV
is: SBO:0000176
name: transport of Octadecenoyl-CoA into mitochondrial matrix
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110055#

metaM tyr L c
name: L-tyrosine
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00158
is: CHEBI:17895
boundary condition: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial concentration: 1.0

metaM e4hglu m
name: erythro-4-hydroxy-L-glutamate(1-)
constant: false
is: HMDB02273
initial concentration: 1.0
is: CHEBI:6331
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
is: SBO:0000247
type: Species

metaR RE2649M
name: RE2649
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (10965.1) or (11332.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:IT - fixed proton
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.2
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110055#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_a5d9eb09_ba07_4632_9416_d896916301be
is encoded by: hsa:7296
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
name: TXNRD1

http://identifiers.org/biomodels.db/MODEL1310110055#_2bd18bb7_a496_4135_ba57_2f5607f2e937
initial concentration: NaN
is encoded by: hsa:115286
initial amount: NaN
has only substance units: false
type: Species
name: SLC25A26
boundary condition: true
constant: false
is: SBO:0000252

metaR r2313
product: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110055#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_3d00b884_d904_46c5_b20c_e0bab9753b1a
is: Q53Y25
has only substance units: false
type: Species
initial concentration: NaN
name: GCK
constant: false
boundary condition: true
is encoded by: hsa:2645
is: SBO:0000252
initial amount: NaN

metaR RE2799C
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110055#
is: SBO:0000176
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
reactant: MODEL1310110055#
name: RE2799
reversible: true

metaR MM5ag
modifier: MODEL1310110055#
product: MODEL1310110055#
fast: false
is described by: ECO:0000000
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is: SBO:0000176
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
reversible: false
type: Reaction
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.113

http://identifiers.org/biomodels.db/MODEL1310110055#_d9b75716_d6da_40df_94e2_787b803b38ae
is: O14732
type: Species
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3613
name: IMPA2

metaM octdececoa c
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial amount: NaN
is: HMDB06351
is: SBO:0000247
name: octadecenoylcoa
boundary condition: false
constant: false

metaM ach c
type: Species
constant: false
has only substance units: false
is: CHEBI:15355
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00895
name: acetylcholine
initial amount: NaN

metaM hexdiac r
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C16H28O4 CHARGE: -2
has only substance units: false
type: Species
name: hexadecanediocacid
is: SBO:0000247
constant: false
is: HMDB00672
is: C08260

metaR SGPL12r
kinetic law: MODEL1310110055#
product: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
reversible: false
name: Sphingosine-1-phosphate lyase
type: Reaction
is described by: ECO:0000304
modifier: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.2.27

metaR CYTK5
reactant: MODEL1310110055#
is described by: ECO:0000269
product: MODEL1310110055#
type: Reaction
name: cytidylate kinase (dCMP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR r1621
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
type: Reaction
modifier: MODEL1310110055#
fast: false
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_06c8b296_9306_40ee_aead_6dfb411499c9
boundary condition: true
is: E9PNG0
initial concentration: NaN
type: Species
is encoded by: hsa:271
constant: false
initial amount: NaN
name: AMPD2
has only substance units: false
is: SBO:0000252

metaR r2314
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110055#
type: Reaction
product: MODEL1310110055#
is described by: ECO:0000000
kinetic law: MODEL1310110055#
reversible: true
is: SBO:0000185

metaM lgnc c
name: lignocerate
initial concentration: 1.0
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
is: CHEBI:31014
constant: false
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB02003
initial amount: NaN
has only substance units: false

metaR ARACHCRNt
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000185
type: Reaction
reversible: false
name: transport into the mitochondria (carnitine)
is described by: ECO:0000000
modifier: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_53406779_4709_4776_b2f9_ab0eef80f0e6
constant: false
is: Q49AT3
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8706
type: Species
name: B3GALNT1
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM 10fthf m
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
has only substance units: false
name: 10-formyltetrahydrofolate(2-)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57454
type: Species
constant: false
is: HMDB00972
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_5198a188_1ed3_4aa8_8e28_fdb187a8e2f9
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:594
constant: false
is: P21953
name: BCKDHB
initial amount: NaN

metaM tyr L e
name: L-tyrosine
is: SBO:0000247
initial amount: NaN
is: HMDB00158
has only substance units: false
type: Species
is: CHEBI:17895
boundary condition: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
constant: false
initial concentration: 1.0

metaR r1620
product: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
is: SBO:0000185
reversible: true
modifier: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_ab1d9af5_6210_4ad7_a710_b558263c5304
type: Species
constant: false
is: P31350
initial amount: NaN
is encoded by: hsa:6241
initial concentration: NaN
name: RRM2
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR CYTK6
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
name: cytidylate kinase (CMP,CTP)
fast: false
modifier: MODEL1310110055#
product: MODEL1310110055#

metaR r0249
type: Reaction
reversible: true
product: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
fast: false
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.7.12
modifier: MODEL1310110055#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110055#_36491633_f7b8_4696_9793_14045378c2df
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10948
name: STARD3
type: Species
initial concentration: NaN
has only substance units: false
is: B4DUY1
initial amount: NaN
constant: false

metaM Tn antigen g
is: SBO:0000247
is: C04383
has only substance units: false
name: Tn antigen
initial amount: NaN
notes: FORMULA: C8H14NO5X CHARGE: 0
boundary condition: false
initial concentration: 1.0
type: Species
constant: false

metaR r0647
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
is: SBO:0000176
name: Spontaneous reaction
reactant: MODEL1310110055#
reversible: true
product: MODEL1310110055#
kinetic law: MODEL1310110055#

metaR URATEt
name: urate export from cytosol
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
reversible: false
type: Reaction

metaR FAOXC102x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)x
type: Reaction

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaR ITPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110055#
name: ITP nuclear transport
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true

metaM 6pgc r
is: CHEBI:58759
name: 6-phosphonatooxy-D-gluconate
has only substance units: false
type: Species
is: SBO:0000247
constant: false
is: HMDB01316
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_b9cebcef_bcb6_4f5d_9128_bd2c7df39862
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI090874
is: SBO:0000252
name: _AI090874_1_c
initial amount: NaN
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_0d8d0d36_c7bf_4ee1_ae68_fc5e8c57a967
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:250
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
name: ALPP
is: P05187

metaR r2308
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
product: MODEL1310110055#
fast: false
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185

metaM hdcoa m
initial concentration: 1.0
name: Hexadecenoyl-CoA (n-C16:1CoA)
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
is: HMDB06532
initial amount: NaN
constant: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4

metaR HOCDACBP
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxyoctadecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM HC00591 m
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
name: 2-oxoglutaramate
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:16769
initial amount: NaN
boundary condition: false
type: Species

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaM HC01602 c
constant: false
is: CHEBI:57454
name: 10-Formyltetrahydrofolate
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: C00234
is: SBO:0000247
has only substance units: false

metaM pap g
type: Species
has only substance units: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00061
initial amount: NaN
name: adenosine 3',5'-bismonophosphate(4-)
is: CHEBI:58343
boundary condition: false

metaM succoa x
is: SBO:0000247
is: HMDB01022
constant: false
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
name: Succinyl-CoA
initial concentration: 1.0

metaR RE3272N
fast: false
product: MODEL1310110055#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110055#
name: RE3272
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
kinetic law: MODEL1310110055#

metaM phyt e
is: CHEBI:37257
name: phytanate
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
is: HMDB00801
type: Species
is: SBO:0000247
boundary condition: false

metaM progly c
constant: false
is: HMDB11178
boundary condition: false
type: Species
is: SBO:0000247
name: L-Prolinylglycine
notes: FORMULA: C7H12N2O3 CHARGE: 0
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM ksi pre2 g
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C87H142N6O62X CHARGE: -1
name: keratan sulfate I biosynthesis, precursor 2
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00175
is: CHEBI:58053
boundary condition: false
is: C00130
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_98f05cfd_e7d0_41d4_9bb8_1fe495674c50
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1716
name: DGUOK

http://identifiers.org/biomodels.db/MODEL1310110055#_3d189367_e699_41dc_a7fd_f9b4d3698372
has only substance units: false
initial amount: NaN
type: Species
name: ALDH3A1
constant: false
is: SBO:0000252
is: P30838
boundary condition: true
is encoded by: hsa:218
initial concentration: NaN

metaM cs e l
constant: false
has only substance units: false
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
boundary condition: false
is: HMDB02183
is: CHEBI:36005
initial concentration: 1.0
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
type: Species
initial amount: NaN

metaM ksi deg41 l
is: HMDB00143
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I, degradation product 41
boundary condition: false
notes: FORMULA: C34H58N2O26 CHARGE: 0
is: SBO:0000247
is: CHEBI:12936
has only substance units: false

metaR XYLt
fast: false
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
name: D-xylose reversible transport
is: SBO:0000185
reversible: true
reactant: MODEL1310110055#

metaM 4mlacac c
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
is: HMDB02052
type: Species
is: CHEBI:17105
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
name: 4-maleylacetoacetate
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_cdc4baf3_521a_4d1d_a7d9_5d340f0b03c2
name: ESPN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:83715
is: B1AK53
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false

metaR EX ivcrn
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for isovaleryl carnitine
type: Reaction

metaM phyt c
has only substance units: false
is: SBO:0000247
name: phytanate
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
is: HMDB00801
initial amount: NaN
is: CHEBI:37257
constant: false
initial concentration: 1.0
boundary condition: false
type: Species

metaM CE2250 e
boundary condition: false
initial amount: NaN
is: CHEBI:52328
has only substance units: false
notes: FORMULA: C43H72N7O18P3S CHARGE: -4 INCHI: InChI=1S/C43H76N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-31(51)26-34(53)72-25-24-45-33(52)22-23-46-41(56)38(55)43(2,3)28-65-71(62,63)68-70(60,61)64-27-32-37(67-69(57,58)59)36(54)42(66-32)50-30-49-35-39(44)47-29-48-40(35)50/h29-30,32,36-38,42,54-55H,4-28H2,1-3H3,(H,45,52)(H,46,56)(H,60,61)(H,62,63)(H2,44,47,48)(H2,57,58,59)/t32-,36-,37-,38+,42-/m1/s1 EHMN_ABBREVIATION: CE2250
initial concentration: 1.0
name: 3-oxodocosanoyl-CoA
type: Species
constant: false
is: SBO:0000247

metaM n2m2mn l
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00939
initial concentration: 1.0
notes: FORMULA: C42H71N3O31 CHARGE: 0
is: CHEBI:16680
constant: false
initial amount: NaN
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)

metaR C100CPT1
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decanoylcarnitine
type: Reaction

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaM didp n
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:28823
type: Species
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
initial concentration: 1.0
is: HMDB03536
name: dIDP
has only substance units: false

metaR RE1810M
is described by: ECO:0000000
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000176
name: RE1810
type: Reaction
fast: false
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_879e7f06_5818_4c91_9af0_d3c45c19d147
is: P43166
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:766
boundary condition: true
constant: false
initial amount: NaN
name: CA7

http://identifiers.org/biomodels.db/MODEL1310110055#_e533fbfe_9803_482c_942c_07573a437b57
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: FLAD1
is: SBO:0000252
constant: false
is: Q8NFF5
has only substance units: false
is encoded by: hsa:80308

metaM retinal 11 cis c
type: Species
initial amount: NaN
initial concentration: 1.0
name: 11-cis-retinal
has only substance units: false
constant: false
is: HMDB02152
is: CHEBI:16066
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
boundary condition: false
is: SBO:0000247

metaR r0797
kinetic law: MODEL1310110055#
reversible: true
modifier: MODEL1310110055#
name: glycine N-choloyltransferase EC:2.3.1.65
is: SBO:0000176
fast: false
reactant: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
is described by: ECO:0000000
product: MODEL1310110055#

metaR r0644
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110055#
is: SBO:0000176
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reversible: true
product: MODEL1310110055#

metaR DURIt
kinetic law: MODEL1310110055#
name: deoxyuridine transport via diffusion
reversible: true
type: Reaction
product: MODEL1310110055#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
fast: false
reactant: MODEL1310110055#

metaR GLU5Km
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110055#
name: glutamate 5-kinase (m)
modifier: MODEL1310110055#
reactant: MODEL1310110055#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.41
product: MODEL1310110055#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 2.7.2.11 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m

metaM malthx e
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
is: SBO:0000247
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/5041
name: Maltohexaose
is: C01936
boundary condition: false

metaM progly e
boundary condition: false
is: HMDB11178
notes: FORMULA: C7H12N2O3 CHARGE: 0
constant: false
has only substance units: false
name: L-Prolinylglycine
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR GALASE3ly
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
is: SBO:0000176
kinetic law: MODEL1310110055#
reversible: false
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110055#

metaR r0796
type: Reaction
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110055#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110055#
reversible: true
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
is: SBO:0000176

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaM cholate e
is: CHEBI:29747
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
name: Cholate
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00619
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695

metaR HSD3A2r
is version of: http://identifiers.org/ec-code/1.1.1.225
is described by: ECO:0000000
is: SBO:0000176
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
product: MODEL1310110055#
reversible: true
reactant: MODEL1310110055#
modifier: MODEL1310110055#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
kinetic law: MODEL1310110055#

metaR PRISTANALtx
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
reversible: true
reactant: MODEL1310110055#
product: MODEL1310110055#
name: pristanal peroxisomal transport
kinetic law: MODEL1310110055#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR N3Tg
reactant: MODEL1310110055#
fast: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.122
reversible: false
product: MODEL1310110055#
modifier: MODEL1310110055#
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
type: Reaction
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_28fcab38_23ae_46f2_812b_d942c552baa8
constant: false
is encoded by: hsa:5372
is: A8K003
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: PMM1

http://identifiers.org/biomodels.db/MODEL1310110055#_32950aa6_b1e3_43e2_9036_60a667518c3d
has only substance units: false
is: D3DX95
name: CHAT
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:1103
initial amount: NaN
is: SBO:0000252

metaR IDPtn
reactant: MODEL1310110055#
is: SBO:0000185
product: MODEL1310110055#
name: IDP nuclear transport
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110055#_84b929fd_5b27_4614_91e8_dfda34010475
boundary condition: true
constant: false
type: Species
has only substance units: false
is encoded by: hsa:AI620219
is: SBO:0000252
name: _AI620219_1_m
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_e1683b1d_7335_4f64_982a_d8480a50fe62
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: ALDH3A2
is: P51648
constant: false
has only substance units: false
type: Species
is encoded by: hsa:224

metaM chlstol r
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
type: Species
is: HMDB06842
is: CHEBI:16290
name: 5alpha-cholesta-7,24-dien-3beta-ol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_1f43fea8_6352_424d_9481_712f5f7a16ac
initial concentration: NaN
name: BPGM
initial amount: NaN
is encoded by: hsa:669
boundary condition: true
is: P07738
has only substance units: false
is: SBO:0000252
constant: false
type: Species

metaM sgalside hs c
is: HMDB03406
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
constant: false
is: SBO:0000247
is: CHEBI:16523
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
name: sulfatide galactocerebroside
has only substance units: false

metaM dad 2 c
is: HMDB00101
type: Species
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: 2-deoxyadenosine
constant: false
initial concentration: 1.0
is: CHEBI:17256

metaM adrncoa x
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205480
type: Species
name: adrenyl coenzyme A
has only substance units: false
constant: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
initial amount: NaN
is: SBO:0000247
is: C16170

metaR ACACT1rm
kinetic law: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110055#
is: SBO:0000176
fast: false
modifier: MODEL1310110055#
name: acetyl-CoA C-acetyltransferase, mitochondrial
is version of: http://identifiers.org/ec-code/2.3.1.9
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR RE2649C
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000000
type: Reaction
name: RE2649
modifier: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false
kinetic law: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:

metaR HDDACBP
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_97884faa_4d68_4f7f_8cb1_e4c530ca16a3
is: Q9Y6M9
is encoded by: hsa:4715
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
name: NDUFB9

metaM dutp n
is: HMDB01191
initial amount: NaN
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
constant: false
is: SBO:0000247
name: dUTP
is: CHEBI:17625

metaR ACP1 FMN
is: SBO:0000176
type: Reaction
modifier: MODEL1310110055#
name: acid phosphatase (FMN)
product: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.2
notes: GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:8522318 NOTES:INVALID ECO TERM: IFH
kinetic law: MODEL1310110055#
is described by: ECO:0000254
reversible: false

metaR DOLPH Ler
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
is described by: ECO:0000000
name: Dolichol-phosphate phosphohydrolase, human (liver)
reactant: MODEL1310110055#
type: Reaction
product: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110055#_e699646b_47c3_4b1c_be9a_2c4ff214ed1a
boundary condition: true
initial amount: NaN
is: P14410
is encoded by: hsa:6476
constant: false
name: SI
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM 3ivcoa m
is: http://identifiers.org/pubchem.compound/11966188
is: HMDB06870
constant: false
is: C05998
boundary condition: false
name: 3-hydroxyisovalerylcoa
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_6df1b29f_321c_4140_bf79_7ecffaa290ea
initial concentration: NaN
constant: false
initial amount: NaN
name: CA7
boundary condition: true
type: Species
is encoded by: hsa:766
is: SBO:0000252
has only substance units: false
is: Q86YU0

http://identifiers.org/biomodels.db/MODEL1310110055#_9c5e1de4_3bd7_4979_a5a4_50cb53294f47
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
name: PHPT1
type: Species
is: Q9P019
is encoded by: hsa:29085
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_058ab7ed_406f_42a4_b74c_20afbe0b1059
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:30833
is: Q8TCD5
boundary condition: true
is: SBO:0000252
name: NT5C
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_1f46a48f_01c5_4fab_9a8a_def52d4307e7
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: O75106
is encoded by: hsa:314
has only substance units: false
type: Species
constant: false
name: AOC2
initial concentration: NaN

metaM nadh m
name: Nicotinamide adenine dinucleotide - reduced
type: Species
is: http://identifiers.org/pubchem.compound/3306
is: CHEBI:57945
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: C00004
boundary condition: false
is: SBO:0000247
is: HMDB01487

metaM mmcoa S m
initial concentration: 1.0
type: Species
has only substance units: false
name: (S)-methylmalonyl-CoA(5-)
is: SBO:0000247
boundary condition: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
constant: false
initial amount: NaN
is: HMDB02310
is: CHEBI:57327

http://identifiers.org/biomodels.db/MODEL1310110055#_75fa67f2_3f31_434e_a025_278f516cabc5
boundary condition: true
has only substance units: false
is: Q96L53
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:6487
initial amount: NaN
name: ST3GAL3
constant: false

metaR MDHm
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
name: malate dehydrogenase, mitochondrial
product: MODEL1310110055#
is described by: ECO:0000134
type: Reaction
reversible: true
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.1.1.37
fast: false
is: SBO:0000176
reactant: MODEL1310110055#
modifier: MODEL1310110055#

metaM ru5p D r
boundary condition: false
is: CHEBI:58121
initial amount: NaN
constant: false
type: Species
name: D-ribulose 5-phosphate(2-)
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: HMDB00618
initial concentration: 1.0

metaR FAOXC226205m
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
name: Beta oxidation of long chain fatty acid
type: Reaction
reversible: false
is described by: ECO:0000000
is: SBO:0000176

metaM Tn antigen l
type: Species
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H14NO5X CHARGE: 0
is: SBO:0000247
is: C04383
name: Tn antigen
has only substance units: false
initial concentration: 1.0

metaR SMS
name: Sphingomyelin synthase (homo sapiens)
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
is described by: ECO:0000269
product: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.8.27
is: SBO:0000176
modifier: MODEL1310110055#
type: Reaction

metaM dutp m
name: dUTP
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial concentration: 1.0
has only substance units: false
is: CHEBI:17625
is: HMDB01191
boundary condition: false
type: Species

metaR r2309
reversible: true
is: SBO:0000185
reactant: MODEL1310110055#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110055#
is described by: ECO:0000000
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
fast: false
type: Reaction

metaM c12dccoa c
type: Species
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
name: dodecanedioylcoa
has only substance units: false
is: HMDB00623
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR FRDPtcr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
product: MODEL1310110055#
is described by: ECO:0000134
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: true
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
fast: false
type: Reaction
is: SBO:0000185

metaM HC01405 m
name: (S)-Hydroxyoctanoyl-CoA
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:28632

metaR PHEACGLNt
product: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
type: Reaction
name: PHEACGLN extracellular transport via diffusion
kinetic law: MODEL1310110055#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110055#
is: SBO:0000185

metaR ITCOAL1m
reactant: MODEL1310110055#
is: SBO:0000176
fast: false
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.4
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000304
product: MODEL1310110055#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_bbcc3746_b5d0_4751_83e8_1d8d723896fd
initial amount: NaN
is encoded by: hsa:N63787
boundary condition: true
has only substance units: false
constant: false
type: Species
initial concentration: NaN
name: _N63787_1_c
is: SBO:0000252

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaM hexdpencoa x
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
is: HMDB02288
name: 2,4,7,10,13-hexadecapentaenoylcoa
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_ee7c9136_8ba8_40f8_aec2_d8cedf46c6b5
initial amount: NaN
is: A8K7J7
initial concentration: NaN
name: HK1
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:3098

metaR GLCNACT L
kinetic law: MODEL1310110055#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110055#
product: MODEL1310110055#
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (liver)
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_1814b62b_5b15_473c_bfa1_ea7a8c176a5c
name: GAPDH
boundary condition: true
is encoded by: hsa:2597
is: E7EUT4
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
type: Species

metaM dcyt c
is: HMDB00014
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
name: Deoxycytidine
has only substance units: false
is: C00881
is: CHEBI:15698
initial concentration: 1.0
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881

metaM HC01403 m
name: (S)-Hydroxydecanoyl-CoA
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
initial concentration: 1.0
is: CHEBI:28325
constant: false
initial amount: NaN

metaM tym c
has only substance units: false
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
boundary condition: false
is: SBO:0000247
is: CHEBI:327995
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
name: tyraminium
is: HMDB00306

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaR GLYSNAT5tc
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_54dc461a_d026_4fe0_aac3_d16e1b4c185f
has only substance units: false
is: B3KVI7
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
name: IVD
boundary condition: true
type: Species
is encoded by: hsa:3712

metaM CE5236 c
is: HMDB03952
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
name: O2'-4a-cyclic-tetrahydrobiopterin
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:28002
initial amount: NaN

metaM CE0849 m
initial amount: NaN
has only substance units: false
name: cis,cis-palmito-7,10-dienoyl-CoA
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
constant: false
initial concentration: 1.0
is: CHEBI:57795
boundary condition: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_79919da7_136d_484f_acda_08ea5d31aaa5
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
constant: false
name: PANK2
boundary condition: true
is encoded by: hsa:80025

http://identifiers.org/biomodels.db/MODEL1310110055#_826ce12c_ae0e_4e54_a518_07b28e23fd20
is: SBO:0000252
is: P04745
constant: false
initial concentration: NaN
is encoded by: hsa:277
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
name: AMY1B

metaM didp c
is: HMDB03536
name: dIDP
initial concentration: 1.0
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:28823
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_f42168f8_13f0_41fb_94b4_70f8d170788e
boundary condition: true
initial concentration: NaN
is: Q99808
constant: false
is encoded by: hsa:2030
is: SBO:0000252
has only substance units: false
type: Species
name: SLC29A1
initial amount: NaN

metaR r2023
is: SBO:0000185
fast: false
reactant: MODEL1310110055#
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
product: MODEL1310110055#

metaR AMETt2m
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
is: SBO:0000185
fast: false
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
reactant: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110055#
reversible: true

metaR FAOXC163C142x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)x
type: Reaction

metaM sgalside hs g
boundary condition: false
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
initial concentration: 1.0
is: CHEBI:58343
type: Species
is: SBO:0000247
name: sulfatide galactocerebroside
is: HMDB00061
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_1abb0c42_395a_4d9e_8a6f_ae299facfd94
is: SBO:0000297
type: Species
is encoded by: hsa:518
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_cf4b6477_8627_4af2_bd34_bab2d8eed5c9
initial concentration: NaN
is encoded by: hsa:501
initial amount: NaN
is: SBO:0000252
name: ALDH7A1
boundary condition: true
type: Species
is: E7EPT3
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_38bbbd96_6b81_44d5_97e2_9b70f8c21493
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q9UHI5
name: SLC7A8
constant: false
is encoded by: hsa:23428
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_41906347_28ee_4424_a929_f5ee5c8e4d09
is: O43181
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: NDUFS4
initial amount: NaN
is encoded by: hsa:4724
type: Species
constant: false
has only substance units: false

metaR AKGMALtm
name: alpha-ketoglutarate/malate transporter
fast: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
reactant: MODEL1310110055#
modifier: MODEL1310110055#
product: MODEL1310110055#

metaM cs e deg2 l
is: SBO:0000247
constant: false
is: HMDB01354
type: Species
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
initial concentration: 1.0
is: CHEBI:57455
has only substance units: false
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
initial amount: NaN

metaR TAURt4 2 r
product: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
modifier: MODEL1310110055#
name: taurine transport (sodium symport) (2:1)
is described by: ECO:0000269
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
kinetic law: MODEL1310110055#

metaM ac c
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
boundary condition: false
constant: false
is: HMDB00042
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
name: acetate
is: CHEBI:30089
is: SBO:0000247

metaR PGDI
is version of: http://identifiers.org/ec-code/5.3.99.2
is version of: http://identifiers.org/ec-code/2.5.1.18
name: Prostaglandin-H2 D-isomerase [Precursor]
reversible: true
modifier: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
is described by: ECO:0000269
product: MODEL1310110055#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110055#_cf3356b6_7409_4cea_ab6a_7ab611a1ba72
is: P23677
constant: false
boundary condition: true
has only substance units: false
name: ITPKA
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:3706
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_937cd117_ab50_4935_bb89_1487fec728fe
is encoded by: hsa:3284
boundary condition: true
is: P26439
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: HSD3B2

metaR HEXDICOAACBP
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioyl coa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_5651d9f0_50a9_467b_a1a9_0b028c4824d5
is encoded by: hsa:29925
initial concentration: NaN
is: Q9Y5P6
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: GMPPB

http://identifiers.org/biomodels.db/MODEL1310110055#_a73638e6_1329_46ba_9bd6_38e753d3cf99
is encoded by: hsa:23517
has only substance units: false
constant: false
is: SBO:0000252
is: Q3MHC9
name: SKIV2L2
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR ELAIDCPT2
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
reversible: false
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000176

metaR NACHEX21ly
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
reversible: false

metaR DHPM1
is described by: ECO:0000269
modifier: MODEL1310110055#
reactant: MODEL1310110055#
name: dihydropyrimidinase (5,6-dihydrouracil)
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
is version of: http://identifiers.org/ec-code/3.5.2.2
fast: false
kinetic law: MODEL1310110055#
product: MODEL1310110055#

metaR DHCR71r
is version of: http://identifiers.org/ec-code/1.3.1.21
reactant: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
name: 7-dehydrocholesterol reductase
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
kinetic law: MODEL1310110055#
reversible: false
is: SBO:0000176
product: MODEL1310110055#
fast: false
is described by: ECO:0000134

metaR TRPt4
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
fast: false
is: SBO:0000185
name: L-tryptophan transport in via sodium symport
modifier: MODEL1310110055#
is described by: ECO:0000304
product: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#
type: Reaction

metaM adrncoa m
name: adrenyl coenzyme A
initial concentration: 1.0
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/47205480
is: C16170
constant: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM dad 2 e
constant: false
initial concentration: 1.0
name: 2-deoxyadenosine
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:17256
is: HMDB00101
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431

metaR ELAIDCPT1
is: SBO:0000176
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
name: carnitine O-palmitoyltransferase
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21

metaM cs e deg5 l
initial amount: NaN
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C31H47NO35S3 CHARGE: -4
is: CHEBI:57737
is: HMDB00868
type: Species
constant: false
has only substance units: false

metaM acglcgal14acglcgalgluside hs g
initial amount: NaN
constant: false
name: nLc5Cer
is: SBO:0000247
is: CHEBI:17103
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_50a0e1c2_acd3_42ef_83e2_ebbb55c3ec68
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P11310
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:34
name: ACADM

metaR AMETr
type: Reaction
is: SBO:0000185
name: S-Adenosyl-L-methionine intracellular diffusion
fast: false
reversible: true
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
product: MODEL1310110055#
is described by: ECO:0000000
kinetic law: MODEL1310110055#

metaR PI45P3K
reversible: false
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
modifier: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.153
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
kinetic law: MODEL1310110055#
is described by: ECO:0000000
fast: false
type: Reaction

metaM m4masn g
constant: false
boundary condition: false
is: C05881
is: SBO:0000247
notes: FORMULA: C46H77N2O35X CHARGE: 0
initial concentration: 1.0
has only substance units: false
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_5bf9d7cc_09b2_44e9_9f8f_d6b226a0f19a
type: Species
initial amount: NaN
boundary condition: true
name: SLC24A3
constant: false
is encoded by: hsa:57419
is: Q9HC58
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_6444dc1b_8156_4fe5_adda_81cbbea972b7
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: ALG2
is encoded by: hsa:85365
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_e72b8203_34a5_4659_8369_666a8577087c
is: SBO:0000252
is: Q99707
name: MTR
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4548
type: Species

metaM gm3 hs g
type: Species
has only substance units: false
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:60065
boundary condition: false
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
initial concentration: 1.0

metaR AGPAT1
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.51
type: Reaction
name: 1-acylglycerol-3-phosphate O-acyltransferase 1
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.3.1.15
is: SBO:0000176
product: MODEL1310110055#
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10555.1) or (137964.1) or (56895.1) or (56894.2) or (56894.1) or (55326.1) or (10554.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 2.3.1.51 Confidence Level: 4 AUTHORS: NOTES:FULLR corresponds to acyl/R groups in texts. NJ
fast: false

metaR r0643
fast: false
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:

metaR r1088
name: Active transport
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110055#
is: SBO:0000185

metaR ESTRONEtr
kinetic law: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
fast: false
type: Reaction
name: estrone intracellular transport
product: MODEL1310110055#
is: SBO:0000185
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_48b45af9_558b_4db3_8008_148fc53777da
is encoded by: hsa:4512
is: SBO:0000252
is: Q7GXY8
type: Species
name: COX1
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false

metaR TCYNTt
is: SBO:0000185
product: MODEL1310110055#
reversible: false
name: Thiocyanate transport via diffusion (cytosol to extracellular)
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_3129b686_0f2a_43a2_a50c_c70f4f04d825
is: Q13946
name: PDE7A
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:5150
initial concentration: NaN

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_0e9e0634_d731_49e3_9589_4a46c4cb69b7
initial amount: NaN
is encoded by: hsa:293
is: SBO:0000252
constant: false
name: SLC25A6
is: Q6I9V5
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM CE5132 c
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
is: SBO:0000247
boundary condition: false
is: CHEBI:57923
type: Species

metaR r0139
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reversible: true
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/2.3.2.2
modifier: MODEL1310110055#
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
product: MODEL1310110055#

metaR r0642
reactant: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
product: MODEL1310110055#
is: SBO:0000176
kinetic law: MODEL1310110055#
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
reversible: true

metaM nadh c
type: Species
is: C00004
name: Nicotinamide adenine dinucleotide - reduced
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB01487
is: http://identifiers.org/pubchem.compound/3306
is: CHEBI:57945
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM glu5sa m
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
type: Species
is: C01165
is: CHEBI:17232
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
name: L-Glutamate 5-semialdehyde
is: HMDB02104
initial concentration: 1.0
initial amount: NaN

metaM sgalside hs l
boundary condition: false
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
is: CHEBI:16349
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00904
is: SBO:0000247
name: sulfatide galactocerebroside
constant: false
initial concentration: 1.0

metaR NACHEX27ly
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
modifier: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
is: SBO:0000176
is described by: ECO:0000269
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110055#
product: MODEL1310110055#
name: beta-N-acetylhexosaminidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110055#_0b1a9514_bc93_485e_a46f_cb4fd622006a
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:8608
has only substance units: false
is: O75452
initial amount: NaN
name: RDH16

metaR ETOHtx
reversible: true
is: SBO:0000185
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110055#
is described by: ECO:0000000
fast: false
name: ethanol reversible peroxisomal transport

metaR FAOXC184C164x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)x
type: Reaction

metaM cortsn r
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:16962
initial amount: NaN
notes: FORMULA: C21H28O5 CHARGE: 0 INCHI: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00762
name: cortisone
boundary condition: false
is: SBO:0000247
is: HMDB02802
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_497725b8_1f52_4b7c_b11c_99b4c57b28b7
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6582
type: Species
constant: false
initial amount: NaN
name: SLC22A2
initial concentration: NaN
is: O15244
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_a534f845_3221_4f7c_b1dd_ee499f0d250b
is encoded by: hsa:594
boundary condition: true
name: BCKDHB
type: Species
initial amount: NaN
is: SBO:0000252
is: P21953
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_0dfd5028_7b40_4ac5_892e_8b0f86085124
type: Species
is: Q99519
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:4758
name: NEU1
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM fuc1p L c
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
is: HMDB01265
name: L-Fucose 1-phosphate
is: CHEBI:28319
constant: false
has only substance units: false
initial amount: NaN

metaR r0641
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.4
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
reversible: true
modifier: MODEL1310110055#
product: MODEL1310110055#
kinetic law: MODEL1310110055#
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_da324ed2_39a9_49c2_b4a7_4e43866f3640
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:1608
name: DGKG
is: P49619

metaR ALASm
is: SBO:0000176
type: Reaction
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.3.1.37
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
name: 5-aminolevulinate synthase
kinetic law: MODEL1310110055#
fast: false
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.3.1.29
reversible: false
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110055#_3248cf3c_d9a0_4cad_b35a_5abef53af49b
type: Species
initial concentration: NaN
name: _AI915649_1_c
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI915649
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_44468d33_dd53_4a00_b264_307a24cc256c
is: SBO:0000252
type: Species
is encoded by: hsa:2519
boundary condition: true
name: FUCA2
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q9BTY2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_b8dd8ce1_030c_432a_83b6_3ff65620c613
type: Species
name: FOLR1
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2348

metaM etoh x
name: ethanol
has only substance units: false
is: HMDB00108
is: CHEBI:16236
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
constant: false
boundary condition: false

metaR RE3421R
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
is: SBO:0000176
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#
fast: false
type: Reaction
name: RE3421
reversible: true

metaR r2028
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110055#
is described by: ECO:0000000

metaR DM 4abut LPAREN n RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID: 16643338 NOTES:GABA in the intestine may aid in differentiation and proliferation of epithelial cells. GABA intake by oral administration has been shown to alleviate stress, worry and anxiety and additionally it can also improve human immunity (PMID: 16971751). However the PAT1 transporter located at the apical side of enterocytes have very low affinity for GABA. I have presumed that this oral GABA is used within intestine (unless administered at high very high pharmacological doses, GABA exit from the enterocytes may be mediated by other specifc transporters).
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for 4-Aminobutanoate(n)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_8b3a7cff_b64f_48f2_9e38_5cf6e6796653
has only substance units: false
type: Species
is encoded by: hsa:1103
initial concentration: NaN
name: CHAT
boundary condition: true
initial amount: NaN
is: Q6LEN5
constant: false
is: SBO:0000252

metaR NACHEXA13ly
name: beta-N-acetylhexosaminidase A, lysosomal
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
type: Reaction
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000176
modifier: MODEL1310110055#
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_bf1412b6_ddf5_4274_885d_29a1976ed817
is: SBO:0000252
is: O43451
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:8972
constant: false
name: MGAM
initial concentration: NaN
boundary condition: true

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

metaM cholcoar r
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
is: CHEBI:58677
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB02178
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_7175670d_a7c2_4731_8efd_cd3241570c68
type: Species
is: SBO:0000252
is encoded by: hsa:5169
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: Q308M7
boundary condition: true
name: ENPP3

http://identifiers.org/biomodels.db/MODEL1310110055#_2e1b7457_be3a_4231_95ba_79c9e8738ed6
constant: false
initial amount: NaN
is: Q08828
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: ADCY1
has only substance units: false
is encoded by: hsa:107

metaR NAGAlby
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES:Beta-galactosidase B - no evidence to support this actually happens yet; added by analogy with alpha-galactosidase B (NAGAIy) NJ
kinetic law: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110055#
product: MODEL1310110055#
name: N-acetylgalactosaminidase, beta-
fast: false
is: SBO:0000176

metaR r0575
type: Reaction
kinetic law: MODEL1310110055#
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.48
fast: false
modifier: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
product: MODEL1310110055#

metaR FACOAL180i
type: Reaction
reactant: MODEL1310110055#
fast: false
reversible: false
product: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
kinetic law: MODEL1310110055#
name: C180 fatty acid activation
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_5a069a19_151b_4867_9457_e0fa4a4cc616
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: SMPD3
is encoded by: hsa:55512
boundary condition: true
constant: false
is: A8K0T6

http://identifiers.org/biomodels.db/MODEL1310110055#_68ea570f_28fb_47b1_9418_badf07fd3770
type: Species
is encoded by: hsa:10678
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: B3GNT2
boundary condition: true

metaR NRPPHRt4 2 r
product: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
reversible: true
fast: false
reactant: MODEL1310110055#
is: SBO:0000185
modifier: MODEL1310110055#
is described by: ECO:0000269
name: Norepinephrine reversible transport in via sodium symport (1:2)
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110055#_00b81e27_2e07_4d42_874d_ebb8277cbef8
type: Species
is encoded by: hsa:27010
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: TPK1
initial concentration: NaN
is: F5GZG6
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_6f1bbb0a_b995_4bce_9c4f_c2b19f2e4ba4
type: Species
constant: false
name: CPT1B
initial amount: NaN
is encoded by: hsa:1375
is: E9PCP2
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM dgtp n
is: CHEBI:16497
is: SBO:0000247
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
boundary condition: false
name: dGTP
is: C00286
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB01440
initial amount: NaN

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaM 34dhmald c
boundary condition: false
type: Species
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/7903
is: HMDB06242
is: C05577
name: 3,4-Dihydroxymandelaldehyde
initial concentration: 1.0

metaR Q10H2e
is: SBO:0000185
reactant: MODEL1310110055#
product: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
name: transport of ubiquinol into lymph
type: Reaction
is described by: ECO:0000134

metaR ABTD
reversible: true
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
type: Reaction
is described by: ECO:0000000
product: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
is: SBO:0000176
name: L-arabinitol 4-dehydrogenase

metaM cs e deg6 l
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6
has only substance units: false
is: HMDB01354
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:57455
boundary condition: false
notes: FORMULA: C31H48NO32S2 CHARGE: -3

http://identifiers.org/biomodels.db/MODEL1310110055#_26053806_89a4_4144_b0f6_8993de2ca2a7
is encoded by: hsa:4830
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: NME1
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaM sql r
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
is: HMDB00256
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
name: squalene
is: CHEBI:15440
constant: false

metaR H2CO3D
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110055#
product: MODEL1310110055#
reversible: true
name: carboxylic acid dissociation
fast: false
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
type: Reaction
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/4.2.1.1

http://identifiers.org/biomodels.db/MODEL1310110055#_71900790_36d8_4f1d_9451_bc9c75337833
initial amount: NaN
is encoded by: hsa:6785
constant: false
is: Q9GZR5
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
name: ELOVL4

metaR GBSIDEtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) NJ
name: globoside intracellular transport
is described by: ECO:0000000
product: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
reversible: true
is: SBO:0000185

metaM dtdp n
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01274
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
boundary condition: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate

http://identifiers.org/biomodels.db/MODEL1310110055#_8cfca0df_57fa_4e43_b855_7833cb443f64
constant: false
type: Species
is: P49327
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: FASN
initial concentration: NaN
is encoded by: hsa:2194

http://identifiers.org/biomodels.db/MODEL1310110055#_a78406ab_971a_4128_bd0c_c26c3296f889
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:55967
boundary condition: true
is: F8VQS7
name: NDUFA12
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_db2a74f6_50e8_471d_8b87_189b66029df8
is: Q8NFF2
initial amount: NaN
is: SBO:0000252
name: SLC24A4
is encoded by: hsa:123041
type: Species
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_34bc3519_b02d_4f48_8618_741fc361e2a3
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:60482
is: Q9GZV3
initial amount: NaN
name: SLC5A7
has only substance units: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_a3d95f3e_7746_45b5_8627_ee0f538df85d
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI971023
type: Species
name: _AI971023_1_c
initial concentration: NaN
constant: false

metaM crtsl r
initial amount: NaN
notes: FORMULA: C21H30O5 CHARGE: 0 INCHI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00735
has only substance units: false
is: SBO:0000247
is: CHEBI:17650
type: Species
initial concentration: 1.0
is: HMDB00063
boundary condition: false
constant: false
name: cortisol

metaR GLYCt
name: glycerol transport via channel
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
reactant: MODEL1310110055#
product: MODEL1310110055#
reversible: true
fast: false
kinetic law: MODEL1310110055#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_cae0784b_1e5e_4546_8092_0f000e78f7a9
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:50614
is: SBO:0000252
is: Q9HCQ5
name: GALNT9

metaM occoa m
type: Species
is: CHEBI:57386
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: C01944
name: Octanoyl-CoA (n-C8:0CoA)
constant: false
is: HMDB01070

metaM dtdp m
is: C00363
initial concentration: 1.0
is: CHEBI:58369
constant: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
type: Species
name: dTDP
has only substance units: false
boundary condition: false
is: HMDB01274
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_eea4bc71_92b4_4e84_b505_8de86f140e30
is: O95237
has only substance units: false
initial amount: NaN
is encoded by: hsa:9227
constant: false
name: LRAT
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN

metaR FCOAH
reversible: false
product: MODEL1310110055#
fast: false
type: Reaction
name: formyl coa hydrolase
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11341778,PMID:11591435 NOTES:Note - formcoa formula is uncharged - the correct is FACOAH2 w/ forcoa NJ
is described by: ECO:0000000
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#

metaR PRASCS
modifier: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
product: MODEL1310110055#
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/6.3.2.6
is described by: ECO:0000269
fast: false

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaM phyt x
has only substance units: false
initial amount: NaN
name: phytanate
is: HMDB00801
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
type: Species
is: CHEBI:37257
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_0698a222_a4aa_4ffd_b862_5bb1ed1ecd72
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
name: INPP4B
is: O15327
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:8821

metaR r0578
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
type: Reaction
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/4.1.2.27
is: SBO:0000176
reactant: MODEL1310110055#

metaR ICDHxm
name: Isocitrate dehydrogenase (NAD+)
reactant: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#
fast: false
modifier: MODEL1310110055#
is: SBO:0000176
is described by: ECO:0000134
product: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.41
notes: GENE_ASSOCIATION: (3421.2 and 3420.3 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.3 and 3421.1 and 3419.1) or (3421.1 and 3419.1 and 3420.2) or (3421.2 and 3419.1 and 3420.2) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.41 Confidence Level: 0 AUTHORS: PMID:10601238,PMID:14555658 NOTES:The reaction may be reversible. Strathern shows the reactions as irreversible. IF. Biochemical, Genetic

metaR ADRNCPT2
reversible: false
modifier: MODEL1310110055#
name: carnitine transferase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110055#
fast: false
type: Reaction
kinetic law: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_b9913a4c_b87f_4759_a2bc_73511cc6ec4c
has only substance units: false
initial amount: NaN
is: P33316
is encoded by: hsa:1854
type: Species
name: DUT
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaR r0968
reactant: MODEL1310110055#
is: SBO:0000185
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: false
name: Postulated transport reaction
fast: false
product: MODEL1310110055#

metaM glyc R m
is: CHEBI:16659
is: SBO:0000247
constant: false
type: Species
name: D-glycerate
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
has only substance units: false
is: HMDB00139
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM lneldccrn m
type: Species
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
name: Linoelaidyl carnitine
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB06461

metaR ORNt4m
is described by: ECO:0000269
product: MODEL1310110055#
reversible: true
reactant: MODEL1310110055#
is: SBO:0000185
type: Reaction
fast: false
name: ornithine mitochondrial transport exchange with citruline
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
kinetic law: MODEL1310110055#

metaR SERPT
is described by: ECO:0000269
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.50
name: serine C-palmitoyltransferase
modifier: MODEL1310110055#
type: Reaction
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
product: MODEL1310110055#

metaM ksi pre28 g
is: CHEBI:58053
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 28
has only substance units: false
constant: false
is: HMDB00175
is: C00130
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C213H341N15O176S8X CHARGE: -9

metaM c101coa c
has only substance units: false
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
constant: false
is: HMDB00651
initial amount: NaN
boundary condition: false
name: decenoylcoa
initial concentration: 1.0
is: SBO:0000247

metaM ksi pre3 g
notes: FORMULA: C93H152N6O67X CHARGE: -1
constant: false
is: HMDB00175
initial concentration: 1.0
is: C00130
is: CHEBI:58053
is: SBO:0000247
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 3
boundary condition: false
initial amount: NaN
type: Species

metaR C8DCc
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_26706255_1242_48d1_a06c_5f94bedf1b71
type: Species
is: SBO:0000252
name: ALDOC
is encoded by: hsa:230
boundary condition: true
is: P09972
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN

metaR SEBCOAPET
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

metaR ADRNCPT1
reversible: false
fast: false
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000176
modifier: MODEL1310110055#
name: carnitine O-palmitoyltransferase
type: Reaction
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110055#_5dfffb75_3f80_46aa_b779_4e11774d211c
is: SBO:0000252
is encoded by: hsa:883
initial amount: NaN
is: Q16773
initial concentration: NaN
constant: false
name: CCBL1
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_55f402b9_493d_46f9_ad0f_bdeab352c2f2
name: INPP1
has only substance units: false
boundary condition: true
constant: false
type: Species
is: P49441
is encoded by: hsa:3628
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR RE3005M
modifier: MODEL1310110055#
is: SBO:0000176
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110055#
type: Reaction
fast: false
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
name: RE3005

metaM ptdca c
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: HMDB00826
name: pentadecanoate
is: http://identifiers.org/pubchem.compound/22169126
boundary condition: false
is: SBO:0000247

metaR r0579
modifier: MODEL1310110055#
product: MODEL1310110055#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.19
type: Reaction
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_662dc464_b6f3_4ab8_babc_c26898fab282
constant: false
is: SBO:0000252
name: MTMR6
is encoded by: hsa:9107
is: Q9Y217
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR PGLer
is version of: http://identifiers.org/ec-code/1.1.1.47
kinetic law: MODEL1310110055#
name: 6-phosphogluconolactonase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
type: Reaction
modifier: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
is described by: ECO:0000269
reversible: false
product: MODEL1310110055#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_5451d5f0_beb1_44fc_8e2e_c6746e9275db
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P78382
type: Species
name: SLC35A1
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:10559

http://identifiers.org/biomodels.db/MODEL1310110055#_c1a46986_d293_494f_8ccb_4fde602b34b5
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:51166
has only substance units: false
name: AADAT
is: Q4W5N8
initial amount: NaN
boundary condition: true

metaR RE0935E
name: RE0935
type: Reaction
fast: false
modifier: MODEL1310110055#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1
product: MODEL1310110055#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reactant: MODEL1310110055#

metaR S4TASE4ly
name: N-acetylgalactosamine-4-sulfatase, lysosomal
reversible: true
product: MODEL1310110055#
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.12

metaR It
reversible: true
type: Reaction
is described by: ECO:0000269
product: MODEL1310110055#
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is: SBO:0000185
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
fast: false
name: Iodide uniport

metaR DOLPGT2 Ler
type: Reaction
reactant: MODEL1310110055#
product: MODEL1310110055#
reversible: false
fast: false
modifier: MODEL1310110055#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.4.1.265

metaR LNLNCAt
product: MODEL1310110055#
reversible: true
reactant: MODEL1310110055#
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110055#
is: SBO:0000185
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110055#_5d35d4e2_981b_4cb1_b160_c67e14eb20cd
constant: false
name: ACAA1
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q96CA6
is: SBO:0000252
boundary condition: true
is encoded by: hsa:30

metaR HSD3B11
kinetic law: MODEL1310110055#
type: Reaction
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.1.1.145
is described by: ECO:0000134
modifier: MODEL1310110055#
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
is: SBO:0000176
notes: GENE_ASSOCIATION: (3283.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:16023337 NOTES:progesterone prduction measured after the incubation of human granulosa cells with pregnenolone
fast: false
reactant: MODEL1310110055#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110055#_96bfce4b_0a25_4f4a_93e3_6a0ec44a259f
has only substance units: false
is: P36969
is encoded by: hsa:2879
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: GPX4
constant: false

metaM dtmp m
is: SBO:0000247
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: C00364
initial concentration: 1.0
is: HMDB01227
initial amount: NaN
name: dTMP
type: Species
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:26999

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaM tetdec2crn c
name: tetradecadienoyl carnitine
notes: FORMULA: C21H37NO4 CHARGE: 0
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB02014
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_299c36f6_e411_4f7b_b7a0_5e389f872e33
boundary condition: true
initial amount: NaN
name: SLC2A9
has only substance units: false
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:56606
initial concentration: NaN

metaM HC01115 c
initial concentration: 1.0
type: Species
initial amount: NaN
name: NeuNGc
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
constant: false
is: CHEBI:29025

metaR SGALSIDEtg
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: sgalside hs intracellular transport
kinetic law: MODEL1310110055#
fast: false
type: Reaction
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
product: MODEL1310110055#

metaR CHOLtn
is described by: ECO:0000000
name: Choline transport, nuclear through pores
reversible: true
reactant: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
is: SBO:0000185
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_2b8b5a30_fa6d_4433_85b8_946e530ca0ff
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
constant: false
is encoded by: hsa:516
initial amount: NaN
has only substance units: false
is: SBO:0000297
boundary condition: true
has part: Q6FIH7
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_d88c1e08_6a4e_44c6_a27d_58fe63ed56c1
initial concentration: NaN
name: NDUFV2
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is: P19404
boundary condition: true
is encoded by: hsa:4729

metaR r2371
is: SBO:0000185
product: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: true
kinetic law: MODEL1310110055#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_be9ea742_163f_4d49_a5a2_bf74ade6d142
initial concentration: NaN
type: Species
is: Q9H903
name: MTHFD2L
constant: false
initial amount: NaN
is encoded by: hsa:441024
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM ptdca e
constant: false
is: HMDB00826
type: Species
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/22169126
name: pentadecanoate
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR UAGDP
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.23
reactant: MODEL1310110055#
name: UDP-N-acetylglucosamine diphosphorylase
modifier: MODEL1310110055#
fast: false
type: Reaction
kinetic law: MODEL1310110055#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_433ccbac_054f_42bf_8829_f7af482fda46
name: DCTD
initial amount: NaN
has only substance units: false
is: P32321
type: Species
constant: false
is encoded by: hsa:1635
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_afe6e5fb_f532_42c4_825a_c895d9f00a2a
constant: false
has only substance units: false
is: SBO:0000252
type: Species
name: SLC7A10
is encoded by: hsa:56301
is: Q9NS82
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR AG13T12g
reversible: false
product: MODEL1310110055#
is described by: ECO:0000000
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149

metaR RE2974C
modifier: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.68
product: MODEL1310110055#
type: Reaction
name: RE2974
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.1.149

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaR SADT
reactant: MODEL1310110055#
product: MODEL1310110055#
name: sulfate adenylyltransferase
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.25
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110055#
reversible: false
fast: false
kinetic law: MODEL1310110055#

metaR r0009
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
reversible: false
modifier: MODEL1310110055#
type: Reaction
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.6.1.1
is described by: ECO:0000000
kinetic law: MODEL1310110055#
fast: false
product: MODEL1310110055#
is: SBO:0000176

metaR r2372
kinetic law: MODEL1310110055#
is described by: ECO:0000000
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
product: MODEL1310110055#
reversible: true
type: Reaction
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110055#_23dba61c_c2b3_47e5_89f6_af311f13fd9a
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: Q96AT9
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:6120
name: RPE

metaR NACHEXA18ly
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
kinetic law: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000176
name: beta-N-acetylhexosaminidase A, lysosomal
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_26ab451f_1983_4dcf_8680_f8ce7e0f128e
is: A8K3J4
initial concentration: NaN
type: Species
is encoded by: hsa:23632
name: CA14
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM 2mb2coa c
constant: false
initial amount: NaN
has only substance units: false
name: 2-methylcrotonoyl-CoA(4-)
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB02054
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_2a110976_b53a_4c62_af94_dea20f88f3e6
initial concentration: NaN
initial amount: NaN
name: NDUFB9
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4715
is: Q9Y6M9
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_09baf733_9410_4d91_b1c7_83d46e68bf4e
is encoded by: hsa:54995
name: OXSM
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q9NWU1
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_63e7041b_b3c8_4611_8e08_146d46512b7c
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:518
is: SBO:0000252
constant: false
boundary condition: true
name: ATP5G3

metaR UMPK5n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (dATP),nuclear
product: MODEL1310110055#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110055#
reversible: true

metaR CHOLtu
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
name: Choline uniport
reactant: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false

metaR FATP1t
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
product: MODEL1310110055#
is described by: ECO:0000269
reactant: MODEL1310110055#
modifier: MODEL1310110055#
name: fatty acid electroneutral transport
kinetic law: MODEL1310110055#
is: SBO:0000185

metaM HC02210 c
initial concentration: 1.0
constant: false
initial amount: NaN
name: prostaglandin-d3
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:34939
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1

metaR GALASE7ly
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110055#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
is: SBO:0000176
modifier: MODEL1310110055#

metaR KCCt
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
reversible: true
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
name: K+-Cl- cotransport
reactant: MODEL1310110055#
is described by: ECO:0000269

metaM 3hpcoa m
type: Species
constant: false
is: SBO:0000247
is: CHEBI:58528
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
has only substance units: false
initial amount: NaN
name: 3-hydroxypropanoyl-CoA(4-)
boundary condition: false
initial concentration: 1.0
is: HMDB06807

http://identifiers.org/biomodels.db/MODEL1310110055#_903be7b3_f8e3_4cec_9492_354bb82678ab
is: Q02318
has only substance units: false
initial concentration: NaN
name: CYP27A1
constant: false
boundary condition: true
is encoded by: hsa:1593
is: SBO:0000252
type: Species
initial amount: NaN

metaR PROSTGF2t
name: prostaglandin uniport
modifier: MODEL1310110055#
fast: false
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reversible: true
reactant: MODEL1310110055#
type: Reaction

metaR GBSIDEte
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - The goal of this transporter is to get globoside to the EC plasma membrane NJ
product: MODEL1310110055#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
name: globoside transport
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#

metaR r0688
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
reactant: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000176
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3

metaM ksi deg1 e
is: SBO:0000247
constant: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 1
initial amount: NaN
type: Species
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
is: CHEBI:17268
has only substance units: false
is: HMDB00211
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_cdd15e02_ec62_4954_a642_d3499e935efb
is encoded by: hsa:3631
name: INPP4A
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_1e226f84_bdb9_469e_a586_cfc80b9c1bd8
is: Q308M7
constant: false
has only substance units: false
is encoded by: hsa:5169
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
name: ENPP3
is: SBO:0000252

metaR OCDCAtr
kinetic law: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
product: MODEL1310110055#
name: fatty acid transport via diffusion
reversible: true
reactant: MODEL1310110055#

metaR r0463
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
type: Reaction
kinetic law: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
product: MODEL1310110055#
fast: false
reversible: true
is: SBO:0000176

metaM mi145p c
is: HMDB01498
is: SBO:0000247
is: CHEBI:203600
type: Species
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
constant: false
has only substance units: false
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
initial amount: NaN
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_ee5da47d_c35b_4b3c_8126_8424d7948cf9
name: COX6B2
boundary condition: true
is: Q6YFQ2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:125965
constant: false
type: Species
has only substance units: false

metaR CYTDt
fast: false
reversible: true
is described by: ECO:0000269
product: MODEL1310110055#
name: cytidine facilated transport in cytosol
modifier: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is: SBO:0000185
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_8425a654_e9de_495e_becd_7af170f6c8b9
initial concentration: NaN
has only substance units: false
type: Species
name: ALG8
is encoded by: hsa:79053
initial amount: NaN
is: A6NDW6
boundary condition: true
is: SBO:0000252
constant: false

metaM 34dhmald m
is: HMDB06242
is: SBO:0000247
name: 3,4-Dihydroxymandelaldehyde
type: Species
initial amount: NaN
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
boundary condition: false
is: http://identifiers.org/pubchem.compound/7903
constant: false
initial concentration: 1.0
is: C05577
has only substance units: false

metaR S6T16g
fast: false
product: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110055#
reversible: false

metaM malcoa c
has only substance units: false
type: Species
initial amount: NaN
is: HMDB01175
is: CHEBI:57384
is: C00083
constant: false
is: SBO:0000247
name: Malonyl-CoA
boundary condition: false
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_2ab5a119_9ae4_4bbb_ae27_a9019e1a0d67
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:5287
initial amount: NaN
boundary condition: true
constant: false
name: PIK3C2B
is: O00750
has only substance units: false

metaR r0464
is described by: ECO:0000000
reversible: true
is: SBO:0000176
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
product: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
type: Reaction

metaR FBA2
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110055#
is described by: ECO:0000304
product: MODEL1310110055#
is: SBO:0000176
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/4.1.2.13
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase

http://identifiers.org/biomodels.db/MODEL1310110055#_8e831a72_32a2_4ce0_8c64_56f9a8700ff9
is encoded by: hsa:100287639
boundary condition: true
constant: false
type: Species
has only substance units: false
name: _100287639_1_c
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_380b1c48_2488_47b3_9ea5_6c6d047c9e16
initial concentration: NaN
boundary condition: true
name: PIGA
is encoded by: hsa:5277
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: B3KUV7

http://identifiers.org/biomodels.db/MODEL1310110055#_6c2e20f4_85cc_4e3f_b5ef_69f406c20c77
is: SBO:0000252
is: Q9Y231
name: FUT9
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:10690
constant: false
boundary condition: true
initial concentration: NaN

metaR SIAT4Bg
product: MODEL1310110055#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.4
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
kinetic law: MODEL1310110055#
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
reactant: MODEL1310110055#
modifier: MODEL1310110055#
is: SBO:0000176
fast: false
type: Reaction

metaM focytC m
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
name: Ferrocytochrome C
type: Species
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
is: CHEBI:16928
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_78a96aa5_1853_4b60_8e25_58596bf57294
constant: false
name: ENTPD1
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:953
type: Species
is: Q86VV3
initial concentration: NaN

metaR SGALSIDEtl
type: Reaction
product: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
kinetic law: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is: SBO:0000185
is described by: ECO:0000000
name: sgalside hs intracellular transport

metaM tetdec2crn e
is: SBO:0000247
initial concentration: 1.0
constant: false
name: tetradecadienoyl carnitine
notes: FORMULA: C21H37NO4 CHARGE: 0
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB05066
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_7bacea2e_8e5e_43e2_9d0e_b85cd3b1f7da
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
name: PECR
is encoded by: hsa:55825
is: Q9BY49
type: Species

metaM hs deg22 l
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C37H56NO35S CHARGE: -3
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:21338
is: HMDB02704

metaR r1800
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110055#
reversible: false
type: Reaction
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_f55d51c2_d077_48dd_a722_2321acaf80d6
boundary condition: true
constant: false
type: Species
is: SBO:0000252
has only substance units: false
name: PDE4B
initial amount: NaN
is encoded by: hsa:5142
is: Q5TEK5
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_ed1f9096_a417_4e28_89a5_3ed3c506f5d7
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:6470
initial amount: NaN
name: SHMT1
is: SBO:0000252

metaM malcoa e
initial amount: NaN
type: Species
has only substance units: false
name: malonyl-CoA(4-)
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
constant: false
is: HMDB01175
is: CHEBI:57384
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR r1090
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000185
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
kinetic law: MODEL1310110055#

metaR ADRNt
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: fatty acid transport via diffusion
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_a691802f_7261_4a4a_960c_614ba00088bb
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: ACAA2
is: P42765
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:10449

metaR GLCNACASE2ly
is: SBO:0000176
type: Reaction
fast: false
name: alpha-N-acetylglucosaminidase, lysosomal
reactant: MODEL1310110055#
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.50
is described by: ECO:0000000
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
modifier: MODEL1310110055#
reversible: false

metaR NDPK3n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
kinetic law: MODEL1310110055#
reversible: true
modifier: MODEL1310110055#
is described by: ECO:0000304
product: MODEL1310110055#
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110055#
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR DM ethamp r
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaM dtmp c
type: Species
boundary condition: false
is: SBO:0000247
name: dTMP
is: C00364
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
has only substance units: false
constant: false
is: CHEBI:26999
is: HMDB01227
initial concentration: 1.0
initial amount: NaN

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaM acetone e
is: HMDB01659
boundary condition: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
name: acetone
has only substance units: false
initial amount: NaN
is: CHEBI:15347
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false

metaM kynate c
initial amount: NaN
name: kynurenate
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
is: SBO:0000247
is: CHEBI:58454
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: HMDB00715
boundary condition: false

metaR MAN1PT2
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
modifier: MODEL1310110055#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.13
name: mannose-1-phosphate guanylyltransferase (GDP)
reactant: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#
product: MODEL1310110055#

metaR r0236
product: MODEL1310110055#
reactant: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.5.1.6
kinetic law: MODEL1310110055#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1

http://identifiers.org/biomodels.db/MODEL1310110055#_7a80644a_2805_4089_a1d0_b589eca4e6ff
initial amount: NaN
constant: false
is encoded by: hsa:51205
boundary condition: true
is: SBO:0000252
name: ACP6
initial concentration: NaN
has only substance units: false
type: Species
is: Q9NPH0

metaM HC01444 e
type: Species
is: CHEBI:15754
has only substance units: false
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: Galactosylglycerol
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_5cbdd072_7c5c_43fb_8069_34d97059a1a5
is: Q6IBB5
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4694
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
name: NDUFA1

metaM CE2416 x
is: CHEBI:57923
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)/p-1/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: CE2416
type: Species
name: (2R,6S,10S)-pristanate
constant: false
initial amount: NaN

metaM dtmp e
is: HMDB01227
name: dTMP(2-)
has only substance units: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial concentration: 1.0
boundary condition: false
is: CHEBI:26999
initial amount: NaN
type: Species
constant: false
is: SBO:0000247

metaM 2mb2coa m
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
has only substance units: false
name: 2-methylcrotonoyl-CoA(4-)
initial concentration: 1.0
is: HMDB02054
type: Species
is: SBO:0000247
is: CHEBI:57337
initial amount: NaN
constant: false
boundary condition: false

metaR NDPK3m
is described by: ECO:0000254
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
fast: false
reversible: true
reactant: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
kinetic law: MODEL1310110055#
type: Reaction

metaR DASCBR
is: SBO:0000176
is described by: ECO:0000269
fast: false
name: dehydroascorbate reductase
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.8.4.1
reactant: MODEL1310110055#
reversible: false
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
type: Reaction
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_f999d8ef_4f48_421f_bc38_aff8d831969f
initial amount: NaN
is: H7C5B8
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: NDUFB2
type: Species
boundary condition: true
constant: false
is encoded by: hsa:4708

http://identifiers.org/biomodels.db/MODEL1310110055#_034db8c8_2c2d_44d2_ba89_425a8d479e12
has only substance units: false
boundary condition: true
initial concentration: NaN
name: NDUFC2
type: Species
constant: false
initial amount: NaN
is: Q549M5
is: SBO:0000252
is encoded by: hsa:4718

metaM hmbil c
boundary condition: false
has only substance units: false
is: HMDB01137
initial amount: NaN
notes: FORMULA: C40H38N4O17 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00628 EHMN_ABBREVIATION: C01024
is: C01024
type: Species
is: SBO:0000247
initial concentration: 1.0
name: Hydroxymethylbilane
is: CHEBI:57845
constant: false

metaM acetone c
name: acetone
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB01659
initial concentration: 1.0
is: CHEBI:15347
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207

metaM phyt2ohcoa x
is: CHEBI:57334
type: Species
is: HMDB01295
boundary condition: false
name: 2-hydroxyphytanoyl-CoA(4-)
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)32(50)40(54)70-20-19-43-30(49)17-18-44-38(53)35(52)41(6,7)22-63-69(60,61)66-68(58,59)62-21-29-34(65-67(55,56)57)33(51)39(64-29)48-24-47-31-36(42)45-23-46-37(31)48/h23-29,32-35,39,50-52H,8-22H2,1-7H3,(H,43,49)(H,44,53)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/t26?,27?,28?,29-,32?,33-,34-,35+,39-/m1/s1 EHMN_ABBREVIATION: C07343
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_a0281202_2b8f_4edc_a73d_5e40c6d12247
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: O00154
name: ACOT7
is encoded by: hsa:11332

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaM HC02210 e
type: Species
name: prostaglandin-d3
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:34939
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_684fe16c_2535_4a03_8292_bb44c74066ec
has only substance units: false
name: SLC22A3
is encoded by: hsa:6581
boundary condition: true
is: Q5SYN6
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_7086deb4_048b_42c1_9a04_bacdf235dc39
is: P47895
initial amount: NaN
constant: false
name: ALDH1A3
type: Species
has only substance units: false
is encoded by: hsa:220
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR r0686
reactant: MODEL1310110055#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
product: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
kinetic law: MODEL1310110055#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.3.2.2
is: SBO:0000176
is described by: ECO:0000000

metaR 3MOBt2im
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
product: MODEL1310110055#
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
reversible: false
is described by: ECO:0000000
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport

http://identifiers.org/biomodels.db/MODEL1310110055#_2b8f86a1_3604_4281_b9ab_4988f5b04631
has only substance units: false
constant: false
initial amount: NaN
is: P22234
is: SBO:0000252
name: PAICS
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:10606

metaM hdd2crn m
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: trans-Hexadec-2-enoyl carnitine
constant: false
type: Species
has only substance units: false
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
boundary condition: false
is: HMDB06317

metaR ADCim
is described by: ECO:0000000
fast: false
is: SBO:0000176
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reversible: false
type: Reaction
name: Acetoacetate decarboxylation (irreversible), mitochondrial
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD

metaR C102CPT1
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decadienoylcarnitine
type: Reaction

metaR FAOXC142C122x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)x
type: Reaction

metaM maltttr e
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
is: SBO:0000247
type: Species
name: Maltotetraose
initial concentration: 1.0
constant: false
initial amount: NaN
is: C02052
has only substance units: false
is: HMDB01296
is: http://identifiers.org/pubchem.compound/5141
boundary condition: false

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaM ksii core2 deg5 l
constant: false
is: HMDB00143
notes: FORMULA: C50H82N4O38SX CHARGE: -1
is: SBO:0000247
type: Species
is: CHEBI:12936
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 5
has only substance units: false
boundary condition: false
initial amount: NaN

metaM r5p c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
constant: false
is: HMDB00618
is: CHEBI:18189
initial amount: NaN
is: SBO:0000247
is: C00117
has only substance units: false
type: Species
name: alpha-D-Ribose 5-phosphate

metaR NADtx
fast: false
type: Reaction
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110055#
name: transport of NAD into peroxisome
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110055#
product: MODEL1310110055#

metaR THRGLYexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
modifier: MODEL1310110055#
type: Reaction
name: L-threonine/glycine reversible exchange
product: MODEL1310110055#
is: SBO:0000185
is described by: ECO:0000304
reversible: true
fast: false

metaR r0245
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110055#
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.5.1.3
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
kinetic law: MODEL1310110055#
is: SBO:0000176
modifier: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
type: Reaction

metaR PI5P3K
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.1.153
reactant: MODEL1310110055#
reversible: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.11.1
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.154
is version of: http://identifiers.org/ec-code/2.7.1.137
is described by: ECO:0000000
name: phosphatidylinositol-5-phosphate 3-kinase

metaM strch2 e
constant: false
type: Species
is: HMDB00122
has only substance units: false
notes: FORMULA: C18H32O16 CHARGE: 0
initial amount: NaN
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
is: SBO:0000247
boundary condition: false
is: CHEBI:4167
initial concentration: 1.0

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR r1806
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
modifier: MODEL1310110055#
reversible: false
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#

metaR EX dhdascb LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dehydroascorbide(1-)
type: Reaction

metaR C6DCCACT
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of adipoyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_metaM_galacgalfucgalacglcgal14acglcgalgluside_hs_g
has only substance units: false
type: Species
constant: false
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1
notes: FORMULA: C78H135N4O46FULLRCO CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:26174
boundary condition: false

metaM vacc e
name: trans-vaccenate
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
constant: false
has only substance units: false
is: CHEBI:30828
is: SBO:0000247

metaR C4x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of butyrylcoa to butyrylcarnitine for transport
type: Reaction

metaM pyr e
initial amount: NaN
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: HMDB00243
is: SBO:0000247
type: Species
constant: false
boundary condition: false
name: pyruvate
initial concentration: 1.0
is: CHEBI:15361
has only substance units: false

metaR CRVNCtr
type: Reaction
reactant: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
is: SBO:0000185
name: fatty acid transport via diffusion
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_84a6b593_1c33_44f4_ae1f_33dea8122dec
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: Q9BYC5
is: SBO:0000252
has only substance units: false
name: FUT8
initial concentration: NaN
is encoded by: hsa:2530

metaM ksi pre27 g
name: keratan sulfate I biosynthesis, precursor 27
has only substance units: false
is: CHEBI:58053
is: SBO:0000247
type: Species
is: HMDB00175
is: C00130
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C205H328N14O171S8X CHARGE: -9

metaM CE2424 m
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
boundary condition: false
is: HMDB11123
is: CHEBI:28387

http://identifiers.org/biomodels.db/MODEL1310110055#_7c4aa9d0_62d2_404b_8f37_aa75fd4071a5
constant: false
name: INPP5A
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q14642
is encoded by: hsa:3632
is: SBO:0000252
initial concentration: NaN
type: Species

metaM crn m
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
name: L-Carnitine
is: C00318
type: Species
is: HMDB00062
initial concentration: 1.0
is: CHEBI:16347

metaM lpro m
name: Lipoylprotein
initial concentration: 1.0
is: CHEBI:15804
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: S2X CHARGE: 0 EHMN_ABBREVIATION: C02051
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_b5c19f9c_1e3f_4cf1_a74b_0bff1d1e0071
type: Species
boundary condition: true
initial amount: NaN
is: O75912
constant: false
is: SBO:0000252
is encoded by: hsa:9162
has only substance units: false
name: DGKI
initial concentration: NaN

metaR r0308
reactant: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000000
kinetic law: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
fast: false
reversible: false

metaR EX 3ddcrn
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

metaM m2gacpail hs r
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:16038
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
type: Species
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)

http://identifiers.org/biomodels.db/MODEL1310110055#_dfaaa830_ac7b_4420_9b88_62a42730b2c9
boundary condition: true
name: ATG9B
is: SBO:0000252
is: Q674R7
is encoded by: hsa:285973
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
has only substance units: false

metaR MM6bg
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.113
reversible: false
reactant: MODEL1310110055#
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
type: Reaction
is: SBO:0000176
product: MODEL1310110055#
is described by: ECO:0000000

metaR GLNCYSNaEx
is: SBO:0000185
modifier: MODEL1310110055#
fast: false
reversible: false
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000269
type: Reaction

metaM CE2422 m
type: Species
is: SBO:0000247
is: HMDB11123
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:28387
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_b8efea30_204e_4ad1_ae64_51962ff22bdf
initial concentration: NaN
constant: false
is encoded by: hsa:160287
is: Q6ZMR3
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: LDHAL6A
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_bc1b9778_176e_419c_b1db_2c14a1f3bc6d
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q8NFM4
initial concentration: NaN
is encoded by: hsa:196883
has only substance units: false
name: ADCY4

metaR RPE
name: ribulose 5-phosphate 3-epimerase
reversible: true
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.3.1
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
fast: false
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_dd9d7fb4_b1e2_4de9_bd0e_4c18f9f8fb83
is: Q8IWW8
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
name: ADHFE1
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:137872

metaM o2 e
is: CHEBI:15379
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01377
type: Species
has only substance units: false
initial amount: NaN
is: C00007

metaM ksii core2 pre6 g
name: keratan sulfate II biosynthesis, precursor 6
is: CHEBI:28067
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C61H98N5O46SX CHARGE: -2

metaM pcrn c
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00824
boundary condition: false
type: Species
name: propionyl-carnitine
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
has only substance units: false
is: http://identifiers.org/pubchem.compound/107738

metaM pyr c
type: Species
is: C00022
is: SBO:0000247
is: HMDB00243
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H3O3 CHARGE: -1
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3324
name: pyruvate
boundary condition: false
is: CHEBI:15361

http://identifiers.org/biomodels.db/MODEL1310110055#_c85731a4_b12d_4389_9b85_e98c8db4d2d4
has only substance units: false
boundary condition: true
initial amount: NaN
name: MAN2A1
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is: Q16706
is encoded by: hsa:4124

metaM CE4794 m
name: cis-6-dodecenoyl-CoA
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
constant: false
is: CHEBI:57923
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species

metaR r0246
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: false
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
reactant: MODEL1310110055#
is: SBO:0000176
product: MODEL1310110055#
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_2b177d3d_2f88_4169_838f_a4a91947a5d2
type: Species
is: SBO:0000252
is: Q13454
is encoded by: hsa:7991
name: TUSC3
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false

metaM hs deg12 l
is: SBO:0000247
is: CHEBI:17180
boundary condition: false
is: HMDB01352
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
constant: false
name: heparan sulfate, degradation product 12
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaM xoldioloneh c
is: HMDB06887
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
constant: false
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
initial concentration: 1.0
is: CHEBI:2288
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_c4a16a33_fef5_49be_bc5e_54854da7cca6
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
name: LDHA
constant: false
is encoded by: hsa:3939
initial amount: NaN
is: P00338
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_0106805e_f9bd_4c48_bdbb_f814cb26327a
is: SBO:0000252
initial concentration: NaN
constant: false
name: NDUFB11
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: Q9NX14
is encoded by: hsa:54539

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_a60beca6_7229_49ab_acd6_f62e0cda71f9
name: CYP8B1
constant: false
boundary condition: true
is: Q9UNU6
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:1582
is: SBO:0000252

metaR ARACHCPT1
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110055#
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: carnitine transferase
reversible: false

metaM alpro m
name: S-Aminomethyldihydrolipoylprotein
is: CHEBI:16882
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: CH6NS2X CHARGE: 1 EHMN_ABBREVIATION: C01242

metaR r0853
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
fast: false
kinetic law: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: Facilitated diffusion
reactant: MODEL1310110055#
reversible: false

metaR NS26T2g
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.3
reactant: MODEL1310110055#
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (55808.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.3 Confidence Level: 0 AUTHORS: PMID:10536037 NOTES:NCD
kinetic law: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#
modifier: MODEL1310110055#
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase

metaR GLNSERNaEx
name: L-serine/L-glutamine Na-dependent exchange (Gln-L in)
modifier: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
reactant: MODEL1310110055#
type: Reaction
fast: false
kinetic law: MODEL1310110055#
reversible: false

metaM HC01603 c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial amount: NaN
is: C00234
name: 10-Formyltetrahydrofolate
type: Species
has only substance units: false
is: CHEBI:57454
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_7afb1727_4731_4e43_9ed8_e540d4615180
constant: false
is encoded by: hsa:51703
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
name: ACSL5
is: Q9ULC5
is: SBO:0000252
has only substance units: false

metaM glyc R c
is: HMDB00139
has only substance units: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
name: D-glycerate
boundary condition: false
initial concentration: 1.0
is: CHEBI:16659
constant: false
initial amount: NaN
type: Species
is: SBO:0000247

metaM CE2433 m
constant: false
type: Species
is: SBO:0000247
is: CHEBI:57795
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
initial amount: NaN
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_07018bf8_3339_48e9_97d5_e0941501b8bb
is encoded by: hsa:3292
constant: false
initial amount: NaN
is: SBO:0000252
name: HSD17B1
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: P14061

metaM glyc c
name: Glycerol
type: Species
is: CHEBI:17754
initial amount: NaN
constant: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: HMDB00131
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: C00116

metaM Ser Thr l
initial concentration: 1.0
has only substance units: false
name: protein-linked serine or threonine residue (O-glycosylation site)
type: Species
is: HMDB00224
notes: FORMULA: XH CHARGE: 0
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:58190

metaR ARACHCPT2
is: SBO:0000176
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110055#
product: MODEL1310110055#
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
type: Reaction
fast: false

metaR VITD3t2
name: Vitamin D3 uptake
reactant: MODEL1310110055#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
is: SBO:0000185
product: MODEL1310110055#
type: Reaction
reversible: false
kinetic law: MODEL1310110055#

metaR PTDCAt
fast: false
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
reversible: true
type: Reaction
name: fatty acid transport via diffusion

metaM 3dodtricoa x
is: HMDB11123
constant: false
boundary condition: false
has only substance units: false
is: C05279
initial amount: NaN
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species
name: 3,6,9-dodecatrienoylcoa
is: SBO:0000247

metaR r1803
reversible: false
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000185
fast: false
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#

metaR CYTK7n
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
fast: false
name: cytidylate kinase (CMP,UTP),nuclear
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_e6631b4f_9fa1_4134_84cc_e48cf7ee9647
initial amount: NaN
name: ALG3
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:10195
constant: false

metaR G14T18g
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
kinetic law: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#
reactant: MODEL1310110055#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110055#

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaM 1pyr5c m
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: C03912
constant: false
is: CHEBI:15893
initial amount: NaN
has only substance units: false
name: 1-Pyrroline-5-carboxylate
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01301
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_0cdee7cd_7139_4670_88e3_1e409660402e
type: Species
is: E2QC23
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:23464
has only substance units: false
constant: false
initial concentration: NaN
name: GCAT

http://identifiers.org/biomodels.db/MODEL1310110055#_979d7b54_5000_47a3_8bfc_6760b730e940
has only substance units: false
initial concentration: NaN
type: Species
name: PTDSS1
is: SBO:0000252
initial amount: NaN
is: P48651
boundary condition: true
is encoded by: hsa:9791
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_2abb2e16_c784_464b_aa9f_61cdc92d302e
is encoded by: hsa:T83654
initial amount: NaN
type: Species
constant: false
boundary condition: true
name: _T83654_1_c
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_e17de200_e111_4c03_a0fb_2738f3830db4
boundary condition: true
initial amount: NaN
is encoded by: hsa:8871
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is: O15056
name: SYNJ2

metaR RE1532M
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
product: MODEL1310110055#
name: RE1532
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM occoa x
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: C01944
is: HMDB01070
name: Octanoyl-CoA (n-C8:0CoA)
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57386
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR BHBtm
kinetic law: MODEL1310110055#
is: SBO:0000185
product: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
is described by: ECO:0000000
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_6ce7b926_6124_47c3_977d_349b90a21842
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q9H0I9
is: SBO:0000252
name: TKTL2
type: Species
initial concentration: NaN
is encoded by: hsa:84076

metaR OCTDECCPT2
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaR GRTTx
reactant: MODEL1310110055#
reversible: false
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
type: Reaction
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
product: MODEL1310110055#
fast: false
name: geranyltranstransferase
is version of: http://identifiers.org/ec-code/2.5.1.1

metaR GMPtg
product: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
is: SBO:0000185
name: GMP transport (Golgi)
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_e129f55f_e283_48d2_9031_25892aa3aac4
is: SBO:0000252
name: ESCO2
type: Species
is encoded by: hsa:157570
initial concentration: NaN
has only substance units: false
constant: false
is: Q56NI9
initial amount: NaN
boundary condition: true

metaM glyc e
name: Glycerol
is: SBO:0000247
initial amount: NaN
is: CHEBI:17754
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
constant: false
is: C00116
initial concentration: 1.0
is: HMDB00131

http://identifiers.org/biomodels.db/MODEL1310110055#_e2c3687f_9d10_4e02_b913_13ebc3cb1e8c
initial amount: NaN
is: Q6FGQ4
initial concentration: NaN
is: SBO:0000252
name: PPT1
boundary condition: true
is encoded by: hsa:5538
has only substance units: false
constant: false
type: Species

metaR 3MOBte
product: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 3-methyl-2-oxobutanoate
is: SBO:0000185
reactant: MODEL1310110055#
is described by: ECO:0000134
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_27bed728_fcac_4087_9b94_e6052bb8e6ea
initial concentration: NaN
name: _AA203143_1_c
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:AA203143
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_a2d028ec_a83d_4086_8184_c025d61c8684
constant: false
is encoded by: hsa:5167
type: Species
name: ENPP1
is: P22413
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_ed65b41b_4805_43aa_8628_763503ddf99a
initial concentration: NaN
has only substance units: false
boundary condition: true
name: PANK2
initial amount: NaN
is: Q9BZ23
is encoded by: hsa:80025
constant: false
is: SBO:0000252
type: Species

metaR r0456
is described by: ECO:0000000
modifier: MODEL1310110055#
is: SBO:0000176
fast: false
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
product: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.32
reversible: false
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR OCTDECCPT1
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaR r0242
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
product: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
fast: false
kinetic law: MODEL1310110055#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.1

http://identifiers.org/biomodels.db/MODEL1310110055#_1ed70954_7a30_49bb_a853_dfee85c0f96f
has only substance units: false
is encoded by: hsa:955
constant: false
initial concentration: NaN
is: O75354
type: Species
is: SBO:0000252
name: ENTPD6
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_f88a37a2_1595_4988_bfeb_e987ed04ce99
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has only substance units: false
is encoded by: hsa:9551
type: Species
constant: false
is encoded by: hsa:522
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000297
has part: P56134

metaM Sfglutth c
has only substance units: false
name: S-formylglutathionate(1-)
type: Species
is: CHEBI:57688
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB01550
constant: false
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031

http://identifiers.org/biomodels.db/MODEL1310110055#_3d3c8144_bb62_445c_b810_ee79f697c351
name: FH
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
is: P07954
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2271
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_3334d00d_1e0a_453e_a6ce_4ddaf3e968db
is: Q9BZW2
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:6561
initial amount: NaN
boundary condition: true
name: SLC13A1
initial concentration: NaN

metaR ACSm
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 6.2.1.1 Confidence Level: 2 AUTHORS: PMID:11150295,PMID:4326157 NOTES:IF
product: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#
is described by: ECO:0000304
reactant: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.1
is: SBO:0000176
name: acetyl-CoA synthetase

http://identifiers.org/biomodels.db/MODEL1310110055#_d6ac6360_31ed_40c9_b5c8_065d3f549752
is: SBO:0000252
is: Q6LEN5
has only substance units: false
name: CHAT
is encoded by: hsa:1103
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
type: Species

metaM cs a deg1 l
constant: false
boundary condition: false
is: HMDB01354
has only substance units: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
is: CHEBI:57455
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_886b4de9_7d51_43fe_a3a5_afe548fcceb1
initial concentration: NaN
is: Q96PE7
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:84693
boundary condition: true
initial amount: NaN
type: Species
name: MCEE

metaR PCRNtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
reversible: false
name: transport into the mitochondria from cytosol (carnitine)
reactant: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110055#

metaR r0580
is version of: http://identifiers.org/ec-code/1.3.99.7
reversible: true
fast: false
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
type: Reaction
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
is: SBO:0000176
kinetic law: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#
modifier: MODEL1310110055#

metaM hdd2crn c
name: trans-Hexadec-2-enoyl carnitine
type: Species
boundary condition: false
has only substance units: false
is: HMDB06317
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false

metaR r0962
kinetic law: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
reversible: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: Facilitated diffusion
fast: false
reactant: MODEL1310110055#

metaM crn c
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial concentration: 1.0
constant: false
is: CHEBI:16347
name: L-Carnitine
is: C00318
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00062
has only substance units: false
boundary condition: false

metaR r2374
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
fast: false
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110055#
product: MODEL1310110055#

metaM lneldccrn c
name: Linoelaidyl carnitine
initial amount: NaN
boundary condition: false
is: HMDB06461
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
constant: false
initial concentration: 1.0

metaR DHORTS
is version of: http://identifiers.org/ec-code/2.1.3.2
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
kinetic law: MODEL1310110055#
is: SBO:0000176
product: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
fast: false
modifier: MODEL1310110055#
reversible: true
name: dihydroorotase
is described by: ECO:0000269

metaM Ser Thr g
name: protein-linked serine or threonine residue (O-glycosylation site)
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00645
is: CHEBI:58336
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: XH CHARGE: 0
is: SBO:0000247

metaM CE4790 m
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
is: SBO:0000247
has only substance units: false
constant: false
type: Species
boundary condition: false
is: CHEBI:57923
initial concentration: 1.0
initial amount: NaN

metaM arab L c
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0
constant: false
is: HMDB00646
is: CHEBI:30849
boundary condition: false
name: L-arabinose
initial amount: NaN

metaR ACACt2
modifier: MODEL1310110055#
name: acetoacetate transport via proton symport
fast: false
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
kinetic law: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#
is: SBO:0000185
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110055#_86887dc5_3164_4f41_98b6_03e15944c165
is encoded by: hsa:2109
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: ETFB
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_f5a80206_bae2_4485_952e_a696caca1005
type: Species
is: SBO:0000252
has only substance units: false
is: Q6I9V2
is encoded by: hsa:509
initial concentration: NaN
name: ATP5C1
initial amount: NaN
constant: false
boundary condition: true

metaR r2373
type: Reaction
reactant: MODEL1310110055#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
kinetic law: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
fast: false

metaR ACACT1x
reversible: false
reactant: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.3.1.9
type: Reaction
name: acetyl-CoA C-acetyltransferase, mitochondrial
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
product: MODEL1310110055#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110055#
is described by: ECO:0000134

metaR RIBt
fast: false
is described by: ECO:0000000
product: MODEL1310110055#
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
name: ribose transport via diffusion
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
is: SBO:0000185
type: Reaction

metaM dlnlcgcrn c
name: dihomo-gamma-linolenyl carnitine
initial amount: NaN
type: Species
is: CHEBI:16004
is: HMDB01311
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3

http://identifiers.org/biomodels.db/MODEL1310110055#_7d617e1e_8a43_4e65_bb13_128b706e768c
initial concentration: NaN
type: Species
name: CA5B
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:11238
is: SBO:0000252
has only substance units: false
is: Q9Y2D0

http://identifiers.org/biomodels.db/MODEL1310110055#_b0be16f8_7b73_459b_a610_7922226e3919
has only substance units: false
is: P48200
name: IREB2
constant: false
is encoded by: hsa:3658
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM pyr m
type: Species
is: CHEBI:15361
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
constant: false
initial concentration: 1.0
is: C00022
has only substance units: false
is: SBO:0000247
is: HMDB00243
initial amount: NaN
name: pyruvate
is: http://identifiers.org/pubchem.compound/3324
boundary condition: false

metaR r2030
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110055#
modifier: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_8c52cf0c_f8c8_4f93_a7f1_1295a2d21d67
boundary condition: true
is encoded by: hsa:501
is: E7EPT3
type: Species
is: SBO:0000252
name: ALDH7A1
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_06ee65ed_35d7_44da_baea_350d22a39d3e
type: Species
is: Q9H999
constant: false
is: SBO:0000252
name: PANK3
is encoded by: hsa:79646
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false

metaM sphgn c
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
initial concentration: 1.0
is: SBO:0000247
is: HMDB00269
is: CHEBI:57817
initial amount: NaN
name: sphinganine(1+)
constant: false
type: Species
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_b52e1a2c_9844_4cb6_80d5_f39c9d1c0fd2
is: Q15735
is encoded by: hsa:27124
constant: false
has only substance units: false
is: SBO:0000252
name: INPP5J
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species

metaR PROSTGE1t
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
fast: false
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reversible: true
is described by: ECO:0000269
product: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000185
name: prostaglandin transport via bicarbonate countertransport
type: Reaction

metaM ksii core2 l
constant: false
has only substance units: false
type: Species
boundary condition: false
is: HMDB01014
is: SBO:0000247
name: keratan sulfate II (core 2-linked)
initial amount: NaN
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: CHEBI:57255
initial concentration: 1.0

metaR r2376
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110055#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000000

metaM crn e
constant: false
has only substance units: false
is: C00318
is: CHEBI:16347
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
name: L-Carnitine
type: Species
is: SBO:0000247
is: HMDB00062
boundary condition: false

metaR r0960
reactant: MODEL1310110055#
reversible: true
kinetic law: MODEL1310110055#
product: MODEL1310110055#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_c47664ed_0a58_4248_9377_9f984383f2e1
name: CTH
is: P32929
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:1491
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_d39535e2_6368_42a3_9490_5813a9994634
initial concentration: NaN
has only substance units: false
name: PIK3R2
is: O00459
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:5296
type: Species
is: SBO:0000252

metaR ACNAMtn
fast: false
reversible: false
is described by: ECO:0000000
name: N-acetylneuraminate nuclear import
type: Reaction
product: MODEL1310110055#
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_80eabe7c_bcb5_4639_8ab0_d74d2b2ebf9d
type: Species
has only substance units: false
boundary condition: true
name: DEGS1
constant: false
is encoded by: hsa:8560
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_2cad86a3_6005_4937_8f05_2e13c3e516d2
name: INPP5B
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: P32019
is encoded by: hsa:3633
type: Species

metaM arab L e
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00646
is: CHEBI:30849
type: Species
initial amount: NaN
constant: false
name: L-arabinose

http://identifiers.org/biomodels.db/MODEL1310110055#_fbef46b5_3496_4f13_8db0_99e6741fdeba
is encoded by: hsa:84532
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
name: ACSS1
boundary condition: true
is: Q9NUB1
has only substance units: false

metaR r2375
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
kinetic law: MODEL1310110055#
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaR sink tetdece1coa LPAREN c RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDECE1COASINK
type: Reaction

metaR r0584
modifier: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110055#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110055#
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:

metaR HMGCOARc
reactant: MODEL1310110055#
is described by: ECO:0000134
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
modifier: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.34
type: Reaction
fast: false
product: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
reversible: false

metaM HC02175 e
boundary condition: false
has only substance units: false
name: caprate
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
is: CHEBI:27689
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_3d6ff739_c46e_42e3_9d9c_28f330c4e2ce
constant: false
is: Q9BT22
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:56052
has only substance units: false
name: ALG1
is: SBO:0000252

metaR RE1573M
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110055#
modifier: MODEL1310110055#
name: RE1573
is version of: http://identifiers.org/ec-code/5.3.3.8
reversible: true
kinetic law: MODEL1310110055#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110055#_455d7b84_7085_4dc1_8b09_61da667325b7
initial amount: NaN
initial concentration: NaN
name: ALDH3A2
is: P51648
has only substance units: false
is encoded by: hsa:224
boundary condition: true
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_981280bf_2be8_4dc8_b2ed_06cdf576526d
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:55568
boundary condition: true
has only substance units: false
constant: false
type: Species
name: GALNT10

metaM orot5p c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: C01103
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
name: Orotidine 5'-phosphate
type: Species
constant: false
is: CHEBI:57538
initial amount: NaN
is: HMDB00218

metaM o2 c
type: Species
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
name: O2
is: SBO:0000247
is: HMDB01377
boundary condition: false
is: C00007
constant: false
initial concentration: 1.0
is: CHEBI:15379

metaR r2378
product: MODEL1310110055#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110055#_2f1b0056_689f_4d03_ab05_d8f02c583cf2
initial amount: NaN
name: B3GALT5
is encoded by: hsa:10317
constant: false
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM cs b deg2 l
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
initial amount: NaN
is: HMDB01354
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57455
type: Species
initial concentration: 1.0
notes: FORMULA: C37H54NO41S3 CHARGE: -5

http://identifiers.org/biomodels.db/MODEL1310110055#_7c9f7dc9_49c7_49c2_8ec9_4830991695da
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5331
name: PLCB3
has only substance units: false
is: G5E960
type: Species
initial concentration: NaN

metaR GDPtg
reactant: MODEL1310110055#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
kinetic law: MODEL1310110055#
name: GDP intracellular transport
type: Reaction
product: MODEL1310110055#
is: SBO:0000185
reversible: true

metaR DCMPDA
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.5.4.12
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
name: dCMP deaminase
product: MODEL1310110055#
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_9abdf821_2433_47d3_a5e3_4b46321947a6
is encoded by: hsa:2590
type: Species
initial concentration: NaN
is: Q10471
name: GALNT2
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR r0010
notes: GENE_ASSOCIATION: (25841.1) or (847.1) SUBSYSTEM: ROS detoxification EC Number: 1.11.1.6 Confidence Level: 0 AUTHORS: PMID:12054464,PMID:1657986 NOTES:
is version of: http://identifiers.org/ec-code/1.11.1.6
modifier: MODEL1310110055#
is described by: ECO:0000000
type: Reaction
name: hydrogen-peroxide:hydrogen-peroxide oxidoreductase EC:1.11.1.6
reactant: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000176
fast: false
reversible: false
kinetic law: MODEL1310110055#

metaM galthcrm hs g
constant: false
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
name: Gal-Gal-Gal-Glc-Cer
notes: FORMULA: C42H76NO22FULLRCO CHARGE: 0
initial concentration: 1.0
is: CHEBI:26174
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_6dde50db_d51f_4f5c_80d0_97ca04e0e56b
initial amount: NaN
constant: false
is: Q9HAS3
name: SLC28A3
is encoded by: hsa:64078
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM glyc m
is: SBO:0000247
initial amount: NaN
is: CHEBI:17754
is: HMDB00131
name: Glycerol
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: C00116
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_d984e561_26ee_45ed_9cdb_b31d64f5da31
is: P07741
is: SBO:0000252
type: Species
is encoded by: hsa:353
initial concentration: NaN
has only substance units: false
boundary condition: true
name: APRT
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_0b2df394_9c79_40c9_93a0_556a348db581
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
constant: false
name: GGT2
initial concentration: NaN
is encoded by: hsa:728441
is: SBO:0000252

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaM ksii core2 e
is: CHEBI:17268
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
name: keratan sulfate II (core 2-linked)
is: HMDB00211
boundary condition: false
initial concentration: 1.0

metaR FORMCOAtx
reactant: MODEL1310110055#
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110055#
name: formyl coa transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism see Verhoeven 11591435 and clayton 11356171 - added for peroxisomal oxidation of fatty acids NJ
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110055#

metaR r2377
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: true
product: MODEL1310110055#
type: Reaction
is: SBO:0000185

metaM zym int2 r
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:52386
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
name: zymosterol intermediate 2
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1

metaM phytcoa c
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:57391
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
name: phytanoyl-CoA(4-)
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB01359
has only substance units: false

metaR RE1448N
product: MODEL1310110055#
reversible: true
kinetic law: MODEL1310110055#
name: RE1448
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
reactant: MODEL1310110055#
is described by: ECO:0000000

metaR PROGLYPEPT1tc
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Prolylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR RPI
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
modifier: MODEL1310110055#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/5.3.1.6
product: MODEL1310110055#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110055#
reversible: true
name: ribose-5-phosphate isomerase
reactant: MODEL1310110055#

metaR EX c10crn
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decanoyl carnitine
type: Reaction

metaM HC02175 c
name: caprate
is: SBO:0000247
type: Species
is: CHEBI:27689
initial amount: NaN
constant: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_6ecb85b5_67a2_44dc_9c57_cba8655472be
is encoded by: hsa:5336
is: SBO:0000252
name: PLCG2
has only substance units: false
boundary condition: true
type: Species
is: P16885
initial amount: NaN
initial concentration: NaN
constant: false

metaR RE2349C
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000176
name: RE2349
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.6.1.64
reversible: true
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C

metaR GLYCtm
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
name: glycerol transport
kinetic law: MODEL1310110055#

metaR G14T9g
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
type: Reaction
reactant: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.4.1.22

http://identifiers.org/biomodels.db/MODEL1310110055#_be73b144_6cd8_4e55_a307_df9f8400afcc
type: Species
constant: false
name: SLC25A1
is: SBO:0000252
is encoded by: hsa:6576
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: D9HTE9

metaR 2OXOADPTm
kinetic law: MODEL1310110055#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
name: 2-oxoadipate shuttle (cytosol/mitochondria)
reactant: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110055#

metaR ACACT1r
is described by: ECO:0000000
fast: false
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
is version of: http://identifiers.org/ec-code/2.3.1.9
name: acetyl-CoA C-acetyltransferase
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is: SBO:0000176
type: Reaction
product: MODEL1310110055#
reversible: true

metaR r2379
product: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
reactant: MODEL1310110055#
is: SBO:0000185
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_9e813e1d_d52a_4233_92a5_ef22297e2097
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
name: PANK1
is: Q8TE04
initial amount: NaN
constant: false
is encoded by: hsa:53354
is: SBO:0000252

metaM ksii core2 g
initial amount: NaN
is: HMDB01014
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
name: keratan sulfate II (core 2-linked)
is: SBO:0000247
boundary condition: false
constant: false
type: Species
is: CHEBI:57255
has only substance units: false
initial concentration: 1.0

metaM retfa c
is: HMDB00305
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:50211
initial concentration: 1.0
type: Species
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
initial amount: NaN
name: fatty acid retinol

metaM ksi pre32 g
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:28067
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
name: keratan sulfate I biosynthesis, precursor 32
has only substance units: false

metaM fdp c
name: D-Fructose 1,6-bisphosphate
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3647
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
type: Species
is: CHEBI:16905
is: HMDB01058
is: C00354

metaR r0963
name: Facilitated diffusion
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
fast: false
reversible: false
type: Reaction
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_9576687c_49a7_4c33_82ad_0129cbb7f4b6
is encoded by: hsa:80025
is: SBO:0000252
type: Species
name: PANK2
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR PAPtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110055#
name: adenosine 3',5'-bisphosphate Golgi transport
type: Reaction
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reversible: false
fast: false
is described by: ECO:0000000

metaR FAOXC81C61x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)x
type: Reaction

metaR RE3004M
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110055#
is: SBO:0000176
product: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reversible: true
kinetic law: MODEL1310110055#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110055#
name: RE3004

metaR S6TASE3ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_0e7d2395_b92d_4975_9a79_8128264d2e05
initial concentration: NaN
is encoded by: hsa:272
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
name: AMPD3
is: B7Z763
has only substance units: false
type: Species

metaR r1966
product: MODEL1310110055#
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110055#
reversible: false
reactant: MODEL1310110055#
name: Y+LAT2 Utilized transport
fast: false

metaR SUBERICACT
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of suberic acid for formation of suberyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_9c56203b_ae3e_40d6_94bd_4210d668075d
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: NDUFB5
is: O43674
is encoded by: hsa:4711
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_ed8af4c9_421b_49df_8242_f7095181d6cc
initial concentration: NaN
is: SBO:0000252
is: P36957
type: Species
is encoded by: hsa:1743
constant: false
has only substance units: false
name: DLST
initial amount: NaN
boundary condition: true

metaR GACPAILter
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
name: glucosaminyl-acylphosphatidylinositol ER flippase
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_35c7fd32_a435_4b07_bfab_82948b0d7ae3
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
name: PDE8A
initial concentration: NaN
is encoded by: hsa:5151

http://identifiers.org/biomodels.db/MODEL1310110055#_51387822_923d_4907_b75e_f97a7cc4e511
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
name: ESCO1
is: Q5FWF5
initial concentration: NaN
is encoded by: hsa:114799
type: Species
initial amount: NaN

metaR TSTSTERONEt
reactant: MODEL1310110055#
is: SBO:0000185
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000269
name: Testosterone transport
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
type: Reaction

metaM lnlccoa c
has only substance units: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5462164
type: Species
constant: false
boundary condition: false
is: HMDB01064
initial amount: NaN
name: linoleic coenzyme A

metaM pe hs e
initial amount: NaN
is: SBO:0000247
name: phosphatidylethanolamine
has only substance units: false
is: CHEBI:16038
type: Species
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
boundary condition: false
initial concentration: 1.0
constant: false

metaR NACHEXA11ly
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110055#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
type: Reaction
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: false
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
fast: false
is: SBO:0000176

metaM ksi pre19 g
initial amount: NaN
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
is: C00130
type: Species
constant: false
name: keratan sulfate I biosynthesis, precursor 19
is: HMDB00175
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110055#_5b7ab3b8_38c5_499b_bf57_3cd2f889b681
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10449
is: SBO:0000252
constant: false
has only substance units: false
is: P42765
initial amount: NaN
name: ACAA2

metaM tchola c
constant: false
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
is: HMDB00036
is: CHEBI:36257
name: taurocholic acid
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_2729579d_d09d_44f7_876d_8186dd585f57
is encoded by: hsa:4125
name: MAN2B1
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is: O00754
has only substance units: false
initial amount: NaN

metaM cs e deg4 l
is: CHEBI:15748
is: HMDB00127
notes: FORMULA: C31H46NO38S4 CHARGE: -5
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0

metaM ppa m
initial concentration: 1.0
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: HMDB00237
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: propionate
constant: false
is: CHEBI:17272

http://identifiers.org/biomodels.db/MODEL1310110055#_a15189e7_4114_49e5_9313_8e0439e70739
initial amount: NaN
is encoded by: hsa:5295
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
name: PIK3R1
has only substance units: false
is: B3KT19
boundary condition: true

metaR r0587
product: MODEL1310110055#
type: Reaction
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
modifier: MODEL1310110055#
reversible: true
reactant: MODEL1310110055#
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
kinetic law: MODEL1310110055#

metaR PNTK
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.1.33
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000176
name: pantothenate kinase
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_06c05871_1cfe_4020_89c7_be2ede1be955
initial amount: NaN
has only substance units: false
is encoded by: hsa:2639
boundary condition: true
name: GCDH
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_cb372139_e2ce_4eda_9fd5_0e65d6404800
initial concentration: NaN
is encoded by: hsa:2821
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
name: GPI
boundary condition: true
has only substance units: false
is: P06744

http://identifiers.org/biomodels.db/MODEL1310110055#_7d38f863_64de_414c_a92e_e7744ad15f3f
initial amount: NaN
name: ACP1
type: Species
boundary condition: true
is: Q59EH3
constant: false
initial concentration: NaN
is encoded by: hsa:52
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_061e57b7_42c6_4eff_b902_dd8dea33e17c
constant: false
name: PGM2
is encoded by: hsa:55276
initial amount: NaN
has only substance units: false
type: Species
is: Q96G03
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_6669c306_dd70_4ad5_b193_6e28bdbe4971
constant: false
initial amount: NaN
name: ACHE
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:43
initial concentration: NaN
is: SBO:0000252

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR ACALDt
reactant: MODEL1310110055#
name: acetaldehyde reversible transport
is: SBO:0000185
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
kinetic law: MODEL1310110055#
type: Reaction
fast: false
is described by: ECO:0000000

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaR ORNt3m
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
name: ornithine mitochondrial transport via proton antiport
type: Reaction
kinetic law: MODEL1310110055#
is: SBO:0000185
product: MODEL1310110055#
reversible: true
fast: false
is described by: ECO:0000269
modifier: MODEL1310110055#

metaR FAOXC225C204x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)x
type: Reaction

metaM 1p3h5c m
is: HMDB01369
boundary condition: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
type: Species
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
initial concentration: 1.0
is: CHEBI:6151
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_metaM_fucgalacgalfuc12gal14acglcgalgluside_hs_g
name: Type IIIH glycolipid
initial concentration: 1.0
is: HMDB00304
notes: FORMULA: C70H122N3O40FULLRCO CHARGE: 0
type: Species
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:57847

metaM adp e
type: Species
boundary condition: false
has only substance units: false
name: ADP(3-)
constant: false
initial amount: NaN
is: HMDB01341
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: CHEBI:456216

metaM pep c
is: HMDB00263
is: C00074
constant: false
name: Phosphoenolpyruvate
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:18021

metaR FAOXC16BRx
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16br)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_0c8f2540_56ac_43a3_8501_1a9b296fae0b
is: A8K092
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:498
name: ATP5A1

metaM dlnlcgcrn m
initial concentration: 1.0
is: SBO:0000247
name: dihomo-gamma-linolenyl carnitine
is: CHEBI:16004
constant: false
boundary condition: false
is: HMDB01311
has only substance units: false
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_8a08cdbb_4c98_4728_9537_0dacac98d5a1
is: SBO:0000252
constant: false
is encoded by: hsa:AL050025
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
name: _AL050025_1_c
initial amount: NaN

metaR P450SCC1m
reactant: MODEL1310110055#
reversible: true
is: SBO:0000176
fast: false
kinetic law: MODEL1310110055#
type: Reaction
name: cholesterol monooxygenase
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
is described by: ECO:0000134
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_753ec1ef_c4e5_467d_ad69_ff7a0c89c30c
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: P37287
is: SBO:0000252
name: PIGA
type: Species
is encoded by: hsa:5277

metaM cholcoaone x
constant: false
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
is: CHEBI:58507
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB06891
initial amount: NaN
is: SBO:0000247
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110055#_1c3bcbc6_31e9_4824_b919_29d543a58ae8
constant: false
is: P48735
has only substance units: false
name: IDH2
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:3418
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_354453c3_3374_47f3_bbcd_79422dd25e35
name: ELOVL5
is: F6SH78
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:60481

metaR PFK26
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.105
is: SBO:0000176
name: 6-phosphofructo-2-kinase
reversible: false
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (5210.1) or (5207.1) or (5209.1) or (5208.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.105 Confidence Level: 0 AUTHORS: NOTES:IF
product: MODEL1310110055#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_0db3fdeb_82dc_41e5_b1bd_c65355a22313
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3420
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
name: IDH3B

metaR B3GNT12g
modifier: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (10678.1) or (10678.2) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
type: Reaction
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
reversible: false
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false

metaM doco13ecoa c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892791
initial amount: NaN
name: 13-docosenoylcoa
type: Species
initial concentration: 1.0
constant: false

metaM succ m
is: CHEBI:30031
initial amount: NaN
constant: false
initial concentration: 1.0
name: Succinate
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: C00042
type: Species
boundary condition: false
is: HMDB00254
has only substance units: false
is: SBO:0000247

metaR EX phyt LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phytanic acid exchange
type: Reaction

metaR r2360
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110055#
is described by: ECO:0000000
fast: false
product: MODEL1310110055#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
type: Reaction
reversible: true
reactant: MODEL1310110055#

metaM ksii core4 g
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
is: CHEBI:57255
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate II (core 4-linked)
is: HMDB01014
type: Species
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false

metaM nad c
is: http://identifiers.org/pubchem.compound/3305
type: Species
name: Nicotinamide adenine dinucleotide
constant: false
boundary condition: false
initial concentration: 1.0
is: C00003
is: CHEBI:57540
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00902

http://identifiers.org/biomodels.db/MODEL1310110055#_5c6caadd_2c35_4187_bd2b_6f9e23a895df
has only substance units: false
constant: false
type: Species
boundary condition: true
is encoded by: hsa:29929
is: SBO:0000252
is: Q9Y672
initial concentration: NaN
name: ALG6
initial amount: NaN

metaR PI4PLC
is version of: http://identifiers.org/ec-code/3.1.4.11
product: MODEL1310110055#
reactant: MODEL1310110055#
name: phosphatidylinositol 4-phosphate phospholipase C
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
type: Reaction
is: SBO:0000176
modifier: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#
fast: false

metaR RE1807C
type: Reaction
name: RE1807
reversible: true
kinetic law: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
product: MODEL1310110055#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_31ad28e5_46b4_4f92_a743_01aff0d385f7
is encoded by: hsa:1716
initial amount: NaN
type: Species
name: DGUOK
boundary condition: true
initial concentration: NaN
constant: false
is: E5KSL6
has only substance units: false
is: SBO:0000252

metaM ppa e
has only substance units: false
is: CHEBI:17272
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
constant: false
boundary condition: false
type: Species
name: propionate
is: SBO:0000247
initial concentration: 1.0
is: HMDB00237
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_a12ddb61_b070_40f0_8540_d75deb141371
has only substance units: false
type: Species
constant: false
is: SBO:0000297
boundary condition: true
initial concentration: NaN
is encoded by: hsa:522
has part: Q6NZ59
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
initial amount: NaN

metaM nh4 n
name: ammonium
initial concentration: 1.0
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00051
boundary condition: false
type: Species
is: CHEBI:28938
constant: false

metaR CYSTHRNaEx
name: L-cysteine/L-threonine Na-dependent exchange (Cys-L in)
product: MODEL1310110055#
reversible: false
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is: SBO:0000185
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_8a6966ae_1d04_4d32_b0a6_bf1b4e611900
has only substance units: false
constant: false
is: SBO:0000252
is: E5KS60
name: SUCLA2
is encoded by: hsa:8803
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true

metaR FACOAL2042
is: SBO:0000176
reactant: MODEL1310110055#
product: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000000
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
reversible: true
fast: false

metaM thbpt c
has only substance units: false
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
name: 5,6,7,8-tetrahydrobiopterin
constant: false
is: CHEBI:15372
is: SBO:0000247
is: HMDB00027
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaR r2046
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
modifier: MODEL1310110055#
reversible: false
reactant: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR CSPG Btly
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110055#
reversible: false
reactant: MODEL1310110055#
name: chondroitin sulfate B transport, extracellular to lysosome
fast: false
is: SBO:0000185

metaM 5pmev c
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1
has only substance units: false
type: Species
constant: false
is: HMDB01343
name: (R)-5-phosphonatomevalonate(3-)

metaR AG13T13g
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110055#
reversible: false
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
fast: false
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110055#_8b55b953_9210_42ff_93da_8bdea1bc6866
type: Species
is encoded by: hsa:AI291895
is: SBO:0000252
name: _AI291895_1_c
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_c7c4a95d_fa83_45a2_85f7_a63c13eaabfd
is: B3KXN9
constant: false
type: Species
boundary condition: true
is encoded by: hsa:84890
name: ADO
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM acnam n
type: Species
is: SBO:0000247
name: N-acetylneuraminate
constant: false
initial amount: NaN
is: HMDB00230
boundary condition: false
initial concentration: 1.0
is: CHEBI:35418
has only substance units: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270

metaM nh4 m
name: Ammonium
type: Species
is: CHEBI:28938
constant: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: C01342
is: HMDB00051

metaR PRODt2r
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#
reversible: true
product: MODEL1310110055#
is described by: ECO:0000304
is: SBO:0000185
name: D-proline reversible transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_bdb1a124_4ccd_4457_98b8_5c20170cd69d
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is: Q86V21
name: AACS
is encoded by: hsa:65985
initial concentration: NaN
boundary condition: true

metaM crn x
has only substance units: false
is: C00318
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: CHEBI:16347
is: SBO:0000247
boundary condition: false
constant: false
name: L-Carnitine
type: Species
is: HMDB00062

metaR C80CPT1
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of octanoylcarnitine
type: Reaction

metaM pre prot r
has only substance units: false
notes: FORMULA: XY CHARGE: 0
name: glycophosphatidylinositol (GPI)-anchored protein precursor
is: HMDB03125
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16240
initial amount: NaN
constant: false

metaM tchola e
name: taurocholic acid
is: HMDB00036
notes: FORMULA: C26H45NO7S CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_0b6a9726_1056_4623_880f_3d1079d64930
type: Species
is: SBO:0000252
name: HSD17B4
initial amount: NaN
is: E9PB82
is encoded by: hsa:3295
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_bd32f1c4_3c86_417a_adf4_aee3e0cafba3
has only substance units: false
initial amount: NaN
type: Species
name: _R06874_1_r
is encoded by: hsa:R06874
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252

metaM cs a l
boundary condition: false
is: SBO:0000247
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
is: HMDB02183
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:36005
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_5784921c_d6e5_4692_9d7f_a82a9146cd27
type: Species
initial concentration: NaN
has only substance units: false
is: E7ET32
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2592
constant: false
name: GALT

metaM dsmsterol r
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
boundary condition: false
is: CHEBI:17737
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB02719
has only substance units: false
name: desmosterol

metaM gacpail hs c
initial concentration: 1.0
is: HMDB01401
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: C00092
name: glucosaminyl-acylphosphatidylinositol
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:61548
constant: false
type: Species

metaR S2TASE1ly
product: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.13
is: SBO:0000176
name: iduronate-2-sulfatase, lysosomal
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110055#
fast: false

metaM hxan c
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: CHEBI:17368
name: Hypoxanthine
initial concentration: 1.0
is: C00262
is: HMDB00157
initial amount: NaN
type: Species
boundary condition: false

metaM galgalgalthcrm hs e
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
has only substance units: false
boundary condition: false
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
constant: false
is: C00124
is: HMDB00143
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:0
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_070bf579_5145_4e5c_bd37_2d4d1ee6ab56
initial amount: NaN
type: Species
boundary condition: true
is: Q15392
has only substance units: false
name: DHCR24
is: SBO:0000252
constant: false
is encoded by: hsa:1718
initial concentration: NaN

metaR C226CPT2
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
reactant: MODEL1310110055#
reversible: false
name: C226 transport into the mitochondria
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110055#
is described by: ECO:0000000
kinetic law: MODEL1310110055#
fast: false
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_80cd5c13_670b_4dd9_bc51_64f1d6196b70
constant: false
is encoded by: hsa:4351
initial amount: NaN
name: MPI
is: P34949
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_26298c63_a772_443b_85f1_ff2c60cbb263
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: B2R6S5
type: Species
name: CMPK1
is encoded by: hsa:51727
boundary condition: true
constant: false
is: SBO:0000252

metaR THRSERNaEx
reversible: false
modifier: MODEL1310110055#
is: SBO:0000185
name: L-serine/L-threonine Na-dependent exchange (Thr-L in)
type: Reaction
product: MODEL1310110055#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#

metaR MG1er
product: MODEL1310110055#
reversible: false
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.106
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000000
type: Reaction

metaM 3m4hpga m
is: C05583
is: HMDB04061
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7909
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_67ebdfd0_19b6_4a8c_9dae_05ec16276a27
constant: false
has only substance units: false
name: COX7B2
is: Q8TF08
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:170712
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_4296340f_2ec4_4f57_9ab4_fa6cdd2036dc
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI631997
has only substance units: false
name: _AI631997_1_m
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_acb28366_8d1f_4830_bbad_4b5dfa553eb5
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:275
is: P48728
name: AMT
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false

metaR ASNCYSNaEx
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
reactant: MODEL1310110055#
is: SBO:0000185
modifier: MODEL1310110055#
is described by: ECO:0000269
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
type: Reaction
product: MODEL1310110055#
reversible: false

metaM pcrn m
initial amount: NaN
is: HMDB00824
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/107738
type: Species
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
name: propionyl-carnitine
has only substance units: false

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_0829b8c9_0a03_461a_8db5_be20773d6580
name: PLCB4
is encoded by: hsa:5332
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q15147
type: Species
initial amount: NaN
is: SBO:0000252
constant: false

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_60ba1dfc_8038_4798_b50c_64a2176a6603
type: Species
is: B3KXY9
boundary condition: true
name: HK1
is encoded by: hsa:3098
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM acnam l
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:35418
initial concentration: 1.0
constant: false
is: HMDB00230
type: Species
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
name: N-acetylneuraminate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_7a402bb0_7cd2_47b7_a4cb_57b32cb57cac
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is: A8K8P8
is encoded by: hsa:2530
type: Species
has only substance units: false
name: FUT8
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_348ba6ea_da1b_467e_ae77_9ed31ed35daa
type: Species
name: GMPS
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8833
constant: false
is: SBO:0000252
initial amount: NaN
is: P49915
has only substance units: false

metaR r0450
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.3
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
reactant: MODEL1310110055#
fast: false
modifier: MODEL1310110055#

metaM nad r
is: CHEBI:57540
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB00902
name: NAD(1-)
is: SBO:0000247
boundary condition: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003

metaM dgdp n
type: Species
initial amount: NaN
is: HMDB00960
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:58595
constant: false
name: dGDP(2-)
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361

http://identifiers.org/biomodels.db/MODEL1310110055#_323fc4b0_c53c_4df7_b415_8e31ad6eb22f
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:MBOAT5
initial concentration: NaN
type: Species
name: _MBOAT5_1_c
has only substance units: false

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_33812c76_0d50_4013_9d1a_3e209cf0ffdc
is: SBO:0000252
initial amount: NaN
name: ADA
is: P00813
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:100
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_edfd745a_2828_4720_b150_567bf5d1b408
constant: false
name: ADH1C
has only substance units: false
type: Species
initial concentration: NaN
is: P00326
boundary condition: true
is: SBO:0000252
is encoded by: hsa:126
initial amount: NaN

metaR DUMPtn
reactant: MODEL1310110055#
product: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: dUMP nuclear transport
is: SBO:0000185
reversible: true

metaM galgalgalthcrm hs c
boundary condition: false
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
constant: false
is: HMDB00143
initial amount: NaN
type: Species
is: CHEBI:12936
initial concentration: 1.0
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
is: SBO:0000247
has only substance units: false

metaM hxan e
name: hypoxanthine
boundary condition: false
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
has only substance units: false
is: CHEBI:17368
initial concentration: 1.0
is: HMDB00157
initial amount: NaN
type: Species
constant: false
is: SBO:0000247

metaR HXPRT
type: Reaction
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
kinetic law: MODEL1310110055#
fast: false
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
is version of: http://identifiers.org/ec-code/2.4.2.8
modifier: MODEL1310110055#
reversible: false
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110055#

metaR HS2ly
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.10.1.1
reversible: false
kinetic law: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
modifier: MODEL1310110055#
name: heparan-N-sulfatase, lysosomal
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176

metaM dgdp m
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: HMDB00960
name: dGDP(2-)
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:58595

metaM ppa c
is: CHEBI:17272
name: propionate
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
constant: false
is: SBO:0000247
is: HMDB00237
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_1a22806d_b6dc_49f2_9b4a_7859588b2778
constant: false
is encoded by: hsa:1666
boundary condition: true
name: DECR1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q16698
has only substance units: false

metaR GALASE8ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
modifier: MODEL1310110055#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
reversible: false

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_a7fa7a91_5011_4844_bd2a_5adf86ca2e94
is: Q59FD4
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
name: HK1
is: SBO:0000252
is encoded by: hsa:3098

metaR C226CPT1
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
reversible: false
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
kinetic law: MODEL1310110055#
fast: false
is: SBO:0000176
modifier: MODEL1310110055#
name: carnitine C22:6 transferase
product: MODEL1310110055#
is described by: ECO:0000000

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaR EX adrn LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adrenic acid exchange
type: Reaction

metaM succ e
name: succinate(2-)
has only substance units: false
is: CHEBI:30031
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00254
is: SBO:0000247
type: Species
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042

metaR RE1807M
fast: false
reactant: MODEL1310110055#
is: SBO:0000176
reversible: true
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
modifier: MODEL1310110055#
is described by: ECO:0000000
name: RE1807
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaM ksi deg9 l
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
is: SBO:0000247
is: HMDB00143
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:12936
type: Species
boundary condition: false
name: keratan sulfate I, degradation product 9
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_064923db_e4ee_40a1_a8cc_b21d9d9728dc
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
name: HAS3
is encoded by: hsa:3038
is: O00219

metaR PI45P5P
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
reactant: MODEL1310110055#
modifier: MODEL1310110055#
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.36
fast: false
is: SBO:0000176
product: MODEL1310110055#
is described by: ECO:0000000
type: Reaction
reversible: false

metaR ACALDtx
reactant: MODEL1310110055#
is described by: ECO:0000000
name: acetaldehyde peroxisomal diffusion
fast: false
type: Reaction
product: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110055#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_4d3f21c9_4c26_4c62_8451_2ab5ed0b7e1c
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is: P07195
is encoded by: hsa:3945
boundary condition: true
has only substance units: false
name: LDHB
constant: false

metaR r0698
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.27
product: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
reactant: MODEL1310110055#
type: Reaction
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16

metaR r1962
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
name: Y+LAT2 Utilized transport
is: SBO:0000185
product: MODEL1310110055#
is described by: ECO:0000000
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110055#

metaM tdcrn c
has only substance units: false
notes: FORMULA: C21H41NO4 CHARGE: 0
is: SBO:0000247
constant: false
boundary condition: false
name: myristoyl carnitine
is: HMDB05066
type: Species
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_3a98c8fe_e9e2_47cb_9be8_60f05d64e6be
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:26330
boundary condition: true
initial concentration: NaN
constant: false
name: GAPDHS
is: O14556
type: Species

metaR NDPK4n
product: MODEL1310110055#
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110055#
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
is described by: ECO:0000304
modifier: MODEL1310110055#

metaR A MANASEly
is described by: ECO:0000000
is: SBO:0000176
name: alpha-mannosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.24
product: MODEL1310110055#
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
type: Reaction
reversible: false
modifier: MODEL1310110055#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_4368e2df_07f2_47ac_bc2f_95300e0b1a80
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
name: CAT
initial amount: NaN
is encoded by: hsa:847
initial concentration: NaN
is: P04040
constant: false

metaM adp c
initial concentration: 1.0
name: ADP
initial amount: NaN
is: CHEBI:16761
is: http://identifiers.org/pubchem.compound/3310
type: Species
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
is: HMDB01341
is: C00008

metaM crn r
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: HMDB00062
name: (R)-carnitine
is: CHEBI:16347
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_1d801275_c55f_46aa_b612_fa68b5c7d9c6
initial concentration: NaN
is: SBO:0000252
constant: false
is: Q8TCA4
has only substance units: false
boundary condition: true
is encoded by: hsa:1588
type: Species
initial amount: NaN
name: CYP19A1

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_439db3a5_c38c_4219_8c31_3dcf2a3814ea
name: HIBCH
has only substance units: false
initial concentration: NaN
is encoded by: hsa:26275
initial amount: NaN
is: Q6NVY1
is: SBO:0000252
type: Species
constant: false
boundary condition: true

metaR C160CPT2
modifier: MODEL1310110055#
name: C160 transport into the mitochondria
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110055#
reversible: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110055#
fast: false
product: MODEL1310110055#
is: SBO:0000176

metaR C30CPT1
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of propionylcarnitine
type: Reaction

metaM acnacngalgbside hs e
has only substance units: false
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: HMDB00223
name: disialyl galactosylgloboside
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:3338
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C00036

metaR S6T15g
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.17
is version of: http://identifiers.org/ec-code/2.8.2.21
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110055#_5b63afc2_4f88_41e4_a02b_27faa5c22a71
is encoded by: hsa:55577
type: Species
is: Q9UJ70
constant: false
name: NAGK
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaM galgalgalthcrm hs g
is: SBO:0000247
is: CHEBI:26174
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
constant: false
initial concentration: 1.0
initial amount: NaN
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
boundary condition: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_ec9b51ed_3b3a_4418_bd41_73047b57e36a
type: Species
constant: false
initial amount: NaN
is: Q16795
name: NDUFA9
is encoded by: hsa:4704
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM dc2coa m
boundary condition: false
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
name: trans-Dec-2-enoyl-CoA
is: CHEBI:61406

metaM hpyr c
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
is: CHEBI:17180
is: SBO:0000247
name: 3-hydroxypyruvate
is: HMDB01352
initial amount: NaN
type: Species
constant: false

metaM for r
name: Formate
is: CHEBI:15740
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00142
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: C00058
initial amount: NaN

metaR CYSTGLUex
name: L-cystine/L-glutamate exchanger
is: SBO:0000185
fast: false
is described by: ECO:0000269
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (23657.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
product: MODEL1310110055#
reversible: false
modifier: MODEL1310110055#

metaM ksi pre9 g
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
name: keratan sulfate I biosynthesis, precursor 9
is: HMDB00175
type: Species
is: CHEBI:58053
initial amount: NaN
has only substance units: false
boundary condition: false
is: C00130
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR ALAASNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
fast: false
product: MODEL1310110055#
modifier: MODEL1310110055#
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)
type: Reaction
reactant: MODEL1310110055#
is: SBO:0000185
kinetic law: MODEL1310110055#
is described by: ECO:0000269

metaR C160CPT1
product: MODEL1310110055#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110055#
name: production of Palmitoylcarnitine
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:

metaM tdcrn e
has only substance units: false
is: SBO:0000247
notes: FORMULA: C21H41NO4 CHARGE: 0
constant: false
boundary condition: false
initial amount: NaN
is: HMDB05066
type: Species
name: myristoyl carnitine
initial concentration: 1.0

metaR r0224
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
reversible: false
product: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
is: SBO:0000176

metaM lnlccoa m
type: Species
constant: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: http://identifiers.org/pubchem.compound/5462164
initial amount: NaN
is: SBO:0000247
name: linoleic coenzyme A
boundary condition: false
initial concentration: 1.0
is: HMDB01064
has only substance units: false

metaM succ c
name: Succinate
is: CHEBI:30031
constant: false
is: C00042
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: HMDB00254
boundary condition: false

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

metaM arachdcrn c
name: C20:4 carnitine
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: HMDB01322
is: CHEBI:57387
is: SBO:0000247
constant: false

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

metaR UPP3S
notes: GENE_ASSOCIATION: (7390.1) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.75 Confidence Level: 0 AUTHORS: PMID:3174619 NOTES:
is described by: ECO:0000000
type: Reaction
name: uroporphyrinogen-III synthase
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/4.2.1.75
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#

metaM cs b l
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
boundary condition: false
is: CHEBI:36005
has only substance units: false
is: HMDB02183
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
constant: false
initial concentration: 1.0

metaR 5FTHFt2
product: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (6573.1) or (6573.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:14770311 NOTES:IT
reactant: MODEL1310110055#
fast: false
name: 5-formyltetrahydrofolate transport via anion exchange
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reversible: true
is described by: ECO:0000269
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_22dee6e7_260d_4695_9eb4_3555a337ff0b
initial concentration: NaN
is encoded by: hsa:5464
is: Q15181
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
name: PPA1
has only substance units: false
boundary condition: true

metaR ASNGLNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
product: MODEL1310110055#
is: SBO:0000185
kinetic law: MODEL1310110055#

metaM nad m
boundary condition: false
is: C00003
constant: false
type: Species
is: SBO:0000247
is: HMDB00902
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3305
is: CHEBI:57540
initial amount: NaN
name: Nicotinamide adenine dinucleotide

metaM acnacngalgbside hs g
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
has only substance units: false
is: HMDB00223
initial amount: NaN
is: CHEBI:3338
is: SBO:0000247
boundary condition: false
constant: false
type: Species
name: disialyl galactosylgloboside
is: C00036
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_764f6426_f981_4d2e_ba31_9648ec6980bb
constant: false
initial concentration: NaN
is encoded by: hsa:51227
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000297
type: Species
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ

http://identifiers.org/biomodels.db/MODEL1310110055#_0b777539_1847_470d_b76b_6fd700fa1efe
boundary condition: true
is: Q8N1Q1
type: Species
is encoded by: hsa:377677
initial amount: NaN
name: CA13
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_b2a336d3_5b1c_4fe0_9e8b_bdb8b00a99d7
boundary condition: true
is encoded by: hsa:115286
is: SBO:0000252
has only substance units: false
is: F8WAB8
initial amount: NaN
name: SLC25A26
initial concentration: NaN
type: Species
constant: false

metaR FAOXC16080m
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
fast: false
product: MODEL1310110055#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110055#

metaM pe hs c
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
initial amount: NaN
has only substance units: false
name: phosphatidylethanolamine
is: CHEBI:16038
type: Species

metaM m4mpdol L r
boundary condition: false
is: CHEBI:37633
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
initial amount: NaN
constant: false
initial concentration: 1.0
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_71438d74_de01_4171_a11d_9ca3fcda0bbe
initial amount: NaN
is: O15305
is encoded by: hsa:5373
boundary condition: true
name: PMM2
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_799571d4_96d4_45de_887a_06a6d543143f
has only substance units: false
is: P51687
constant: false
initial amount: NaN
is encoded by: hsa:6821
initial concentration: NaN
name: SUOX
boundary condition: true
is: SBO:0000252
type: Species

metaM ksi deg1 l
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
is: CHEBI:18287
constant: false
is: SBO:0000247
is: HMDB00174
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 1

metaM dece4coa x
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
type: Species
name: 4-decenoylcoa
initial amount: NaN
is: HMDB02145

metaM nh4 c
is: C01342
constant: false
is: SBO:0000247
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
type: Species
boundary condition: false
is: CHEBI:28938
initial amount: NaN
has only substance units: false
name: Ammonium
initial concentration: 1.0

metaM 2mop c
type: Species
boundary condition: false
is: CHEBI:57700
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB01172
name: 2-methyl-3-oxopropanoate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349

metaM cs e deg7 l
is: SBO:0000247
has only substance units: false
is: CHEBI:15936
notes: FORMULA: C23H35O27S2 CHARGE: -3
type: Species
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
boundary condition: false
initial concentration: 1.0
constant: false

metaR GAMt1r
fast: false
is described by: ECO:0000269
reversible: true
name: glucosamine transport (uniport)
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
kinetic law: MODEL1310110055#
is: SBO:0000185
type: Reaction
product: MODEL1310110055#
reactant: MODEL1310110055#
modifier: MODEL1310110055#

metaR r0021
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.6.1.5
is described by: ECO:0000000
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
reactant: MODEL1310110055#
fast: false
type: Reaction
is: SBO:0000176
reversible: true
modifier: MODEL1310110055#
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_7da50fd6_20a4_4185_a8fd_ba0716f3ad04
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:205
constant: false
boundary condition: true
is: SBO:0000252
name: AK4
has only substance units: false

metaM ura c
initial concentration: 1.0
is: CHEBI:17568
type: Species
constant: false
is: HMDB00300
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: C00106
name: Uracil

metaR RE0344C
type: Reaction
reactant: MODEL1310110055#
name: RE0344
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.2
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
reversible: true
fast: false
modifier: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#

metaM acnam c
name: N-acetylneuraminate
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:35418
constant: false
is: HMDB00230
type: Species

metaR XOL7AH2tm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
is: SBO:0000185
type: Reaction
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_d96cea29_9018_4c73_af9a_3d4a9c1c4293
has only substance units: false
is encoded by: hsa:5293
has part: Q92569
boundary condition: true
is encoded by: hsa:8503
name: PIK3CD:PIK3R3
constant: false
type: Species
initial amount: NaN
has part: A7E2E0
initial concentration: NaN
is: SBO:0000297

metaR r0842
reactant: MODEL1310110055#
name: Postulated transport reaction
type: Reaction
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
fast: false
reversible: true
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000000
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.3.1.72

http://identifiers.org/biomodels.db/MODEL1310110055#_041a172d_97ac_4011_9d27_2c48a7a318fd
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: PLA2G5
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5322
is: P39877

metaM octd11ecoa c
is: C08277
is: SBO:0000247
is: HMDB00792
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial amount: NaN
name: 11-octadecenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110055#_5f22b85d_c59d_45fb_8b9f_c32fc9f4376c
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: _LOC728997_1_c
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:LOC728997

http://identifiers.org/biomodels.db/MODEL1310110055#_a24ba23c_80ba_48ec_acc6_b4e840ccc0aa
has part: Q86U05
has only substance units: false
initial amount: NaN
is encoded by: hsa:23428
is: SBO:0000297
boundary condition: true
type: Species
constant: false
initial concentration: NaN
name: SLC7A8:SLC3A2

metaM dhbpt c
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00038
is: SBO:0000247
name: 6,7-dihydrobiopterin
type: Species
has only substance units: false
is: CHEBI:20680

metaM pro D c
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:16313
initial concentration: 1.0
name: D-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: HMDB03411
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_7cf8abf6_a08b_4f5f_b0a9_37fedc8eafbd
constant: false
is: SBO:0000252
has only substance units: false
type: Species
name: AHCYL1
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: O43865
is encoded by: hsa:10768

metaR BTNt4i
fast: false
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000269
is: SBO:0000185
name: Biotin uptake (antiport)
reactant: MODEL1310110055#
reversible: false
type: Reaction
product: MODEL1310110055#

metaM ins c
boundary condition: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
name: Inosine
initial concentration: 1.0
is: SBO:0000247
is: HMDB00195
is: C00294
initial amount: NaN
constant: false
is: CHEBI:17596
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_42383e13_8d42_4034_a1f8_9a70a59e075f
is encoded by: hsa:2181
type: Species
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
name: ACSL3
initial concentration: NaN
is: O95573

http://identifiers.org/biomodels.db/MODEL1310110055#_5f143375_45ac_4c1d_b5a3_2ba459910376
type: Species
name: OGDH
is encoded by: hsa:4967
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q02218
boundary condition: true
constant: false

metaM ksi pre29 g
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:28067
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 29
constant: false
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
initial amount: NaN
has only substance units: false

metaM pi r
name: hydrogenphosphate
is: C00009
boundary condition: false
type: Species
is: HMDB00973
initial concentration: 1.0
is: CHEBI:43474
has only substance units: false
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN
constant: false

metaR RE3556C
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110055#
fast: false
product: MODEL1310110055#
name: RE3556
reactant: MODEL1310110055#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_c0822f81_3b0b_441f_9454_504c20bd1b3c
type: Species
is: A6NED0
initial concentration: NaN
constant: false
name: GSTZ1
boundary condition: true
has only substance units: false
is encoded by: hsa:2954
initial amount: NaN
is: SBO:0000252

metaM acnacngalgbside hs c
is: CHEBI:3338
type: Species
is: HMDB00223
boundary condition: false
has only substance units: false
initial amount: NaN
is: C00036
initial concentration: 1.0
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
name: disialyl galactosylgloboside
is: SBO:0000247
constant: false

metaR RE1533M
fast: false
product: MODEL1310110055#
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
name: RE1533
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM forglu c
has only substance units: false
boundary condition: false
is: HMDB00854
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
name: N-Formimidoyl-L-glutamate
is: SBO:0000247
is: C00439
is: CHEBI:18327
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false

metaR r0845
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12759756,PMID:17466261,PMID:9759482 NOTES:UGLCNACtg but different compartment
kinetic law: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: false
name: Drug/Metabolite Transporter (DMT) TCDB:2.A.7.12.7
reactant: MODEL1310110055#

metaM phytcoa x
is: CHEBI:57391
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
is: SBO:0000247
has only substance units: false
name: phytanoyl-CoA(4-)
is: HMDB01359
type: Species

metaR EICOSTETCRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
modifier: MODEL1310110055#
reversible: false
product: MODEL1310110055#
kinetic law: MODEL1310110055#
name: transport into the mitochondria (carnitine)
reactant: MODEL1310110055#
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaM Lkynr c
is: HMDB00684
initial concentration: 1.0
is: CHEBI:16946
name: L-kynurenine
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328

metaM arachdcrn x
is: CHEBI:17490
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: C20:4 carnitine
constant: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: SBO:0000247
type: Species
is: HMDB00222
initial amount: NaN

metaR INSt4
product: MODEL1310110055#
modifier: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9153.1) or (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:MM
name: inosine transport in via sodium symport
reactant: MODEL1310110055#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_c5c15f60_1872_4363_937e_c88cfcca2410
initial concentration: NaN
name: NDUFAB1
is encoded by: hsa:4706
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is: O14561

metaM xol7a r
has only substance units: false
initial amount: NaN
is: CHEBI:1296
initial concentration: 1.0
name: 20-hydroxycholesterol
boundary condition: false
is: HMDB01496
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594

metaR RE2659R
reversible: true
fast: false
name: RE2659
kinetic law: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
is: SBO:0000176
reactant: MODEL1310110055#
is described by: ECO:0000000
type: Reaction

metaR C161CRN2t
reversible: false
name: C161 transport into the mitochondria
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000269
reactant: MODEL1310110055#
fast: false

metaR r2369
type: Reaction
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110055#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110055#

metaR NACHEX8ly
reactant: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110055#
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
product: MODEL1310110055#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110055#_8696f2d5_631f_4341_b4f2_28d724630f7f
constant: false
type: Species
initial amount: NaN
is: Q9UHV8
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:29124
is: SBO:0000252
name: LGALS13

metaR DHORD9
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
product: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000185
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.5.2
reversible: false
is described by: ECO:0000269
name: dihydoorotic acid dehydrogenase (quinone10)
modifier: MODEL1310110055#
fast: false

metaR CSPG Atly
name: chondroitin sulfate A transport, extracellular to lysosome
fast: false
product: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110055#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110055#_8fda430c_efb2_4726_9c8e_4b3955577a30
initial concentration: NaN
has only substance units: false
is: P30613
boundary condition: true
type: Species
initial amount: NaN
name: PKLR
constant: false
is encoded by: hsa:5313
is: SBO:0000252

metaR FAOXC102C103x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)x
type: Reaction

metaM pro D e
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:16313
is: HMDB03411
initial concentration: 1.0
type: Species
name: D-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110055#_7f6203b7_6070_436b_b226_e6bf6a1d5172
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
name: HSD17B4
is encoded by: hsa:3295
initial concentration: NaN
is: E9PB82

metaM ins e
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
name: Inosine
initial concentration: 1.0
is: HMDB00195
is: C00294
initial amount: NaN
is: CHEBI:17596
constant: false
type: Species

metaM tetdece1crn e
initial concentration: 1.0
boundary condition: false
is: HMDB02014
has only substance units: false
initial amount: NaN
notes: FORMULA: C21H39NO4 CHARGE: 0
constant: false
is: SBO:0000247
name: tetradecenoyl carnitine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_f8c80d12_93e7_4a62_9a56_6da0008f3545
constant: false
initial amount: NaN
boundary condition: true
name: _AI345944_1_m
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:AI345944
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_12bff20b_3165_4a1f_a7a8_a4a2d8aa31fb
initial amount: NaN
has only substance units: false
constant: false
type: Species
initial concentration: NaN
name: DGKD
is encoded by: hsa:8527
is: SBO:0000252
boundary condition: true
is: Q16760

metaM tchola x
is: CHEBI:36257
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00036
boundary condition: false
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
name: taurocholate
is: SBO:0000247
has only substance units: false
constant: false

metaM 3octdece1coa m
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
initial concentration: 1.0
name: 3-hydroxyoctadecenoylcoa
constant: false
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280355

metaR FUCtly
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
reversible: false
is: SBO:0000185
product: MODEL1310110055#
kinetic law: MODEL1310110055#
name: L-fucose efflux from lysosome
fast: false
is described by: ECO:0000000
reactant: MODEL1310110055#

metaM ksi pre6 g
is: HMDB00175
initial amount: NaN
boundary condition: false
is: CHEBI:58053
notes: FORMULA: C107H174N7O80SX CHARGE: -2
is: C00130
type: Species
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 6

http://identifiers.org/biomodels.db/MODEL1310110055#_250c3a2b_04d4_456e_aa8b_9f88819d473c
type: Species
is: P17174
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2805
name: GOT1

metaM pep m
is: C00074
is: HMDB00263
name: Phosphoenolpyruvate
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:18021

metaR BHBt
fast: false
is described by: ECO:0000000
product: MODEL1310110055#
kinetic law: MODEL1310110055#
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
reactant: MODEL1310110055#
reversible: true
is: SBO:0000185

metaR NACHEXA21ly
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is: SBO:0000176
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110055#
type: Reaction

metaR r0590
modifier: MODEL1310110055#
fast: false
product: MODEL1310110055#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
type: Reaction
reactant: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_65f171c7_b29d_4c91_a238_0f724ca592dd
name: CA12
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:771

metaM dtdp c
type: Species
constant: false
has only substance units: false
is: CHEBI:58369
is: C00363
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: dTDP
is: HMDB01274
boundary condition: false

metaR RPEc
name: ribulose 5-phosphate 3-epimerase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
type: Reaction
reversible: true
kinetic law: MODEL1310110055#
is: SBO:0000176
is described by: ECO:0000134
product: MODEL1310110055#
fast: false
reactant: MODEL1310110055#

metaR S23Tg
is described by: ECO:0000269
modifier: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (6482.1) or (6482.2) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:8027041 NOTES:NCD
reversible: false
name: beta-galactoside alpha-2,3-sialyltransferase (T antigen)
type: Reaction
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.4.99.4
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_3c31a1ab_a0b8_43d2_8426_67082f272aa4
is: SBO:0000252
is: O43677
name: NDUFC1
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:4717
has only substance units: false

metaR G14T19g
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110055#
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
kinetic law: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is described by: ECO:0000000

metaR SPC HSt
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
type: Reaction
product: MODEL1310110055#
reversible: true
name: sphingosylphosphorylcholine transport (diffusion)
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110055#

metaR FATP2t
name: fatty acid electroneutral transport
is described by: ECO:0000269
reactant: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110055#
type: Reaction
product: MODEL1310110055#
reversible: true
modifier: MODEL1310110055#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_9c2872a2_afb3_4c12_8b72_be3dedb97a56
has only substance units: false
is: Q9P2X0
name: DPM3
constant: false
is encoded by: hsa:54344
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR CYTK6n
type: Reaction
reversible: true
is described by: ECO:0000269
fast: false
name: cytidylate kinase (CMP,CTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
modifier: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR C121CPT1
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecenoylcarnitine
type: Reaction

metaM 5HPET c
initial concentration: 1.0
constant: false
is: HMDB01193
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:57450
name: 5(S)-HPETE(1-)

metaR UAG4E
is version of: http://identifiers.org/ec-code/5.1.3.2
fast: false
reversible: true
name: UDP-N-acetylglucosamine 4-epimerase
product: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000176
type: Reaction

metaR r0841
product: MODEL1310110055#
name: Free diffusion
fast: false
kinetic law: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.271
is: SBO:0000185
modifier: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
reversible: true

metaM HC01459 x
is: SBO:0000247
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA
boundary condition: false
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:27458

metaR SUCOAS1m
name: Succinate--CoA ligase (GDP-forming)
type: Reaction
reversible: true
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
product: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_751ee077_7e41_47ae_ab1b_b8772a5658a6
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:57835
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: SLC4A5

http://identifiers.org/biomodels.db/MODEL1310110055#_932062c2_350b_4a0d_9d98_cb5093681015
constant: false
is: SBO:0000252
is: O00330
initial amount: NaN
name: PDHX
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8050
type: Species

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaR CERT2gt
kinetic law: MODEL1310110055#
reversible: true
is: SBO:0000185
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000000
reactant: MODEL1310110055#
name: ceramide transport protein
modifier: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside

http://identifiers.org/biomodels.db/MODEL1310110055#_b23c3368_d05b_4096_8169_102a792240d0
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: HAL
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: B4E0V8
is encoded by: hsa:3034

metaR r0443
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.1.1.42
type: Reaction
modifier: MODEL1310110055#
product: MODEL1310110055#
fast: false
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reversible: false
reactant: MODEL1310110055#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_bb9d8476_f09a_45ff_a07d_e05d8a69d049
is: P24752
is encoded by: hsa:38
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
name: ACAT1
is: SBO:0000252
has only substance units: false
constant: false

metaM pi n
is: HMDB00973
initial concentration: 1.0
name: hydrogenphosphate
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
constant: false
is: CHEBI:43474

http://identifiers.org/biomodels.db/MODEL1310110055#_54a474da_8fc9_4be4_94c1_adbc26a2fbcf
boundary condition: true
initial concentration: NaN
is: Q8N3E9
initial amount: NaN
is encoded by: hsa:113026
constant: false
name: PLCD3
type: Species
has only substance units: false
is: SBO:0000252

metaM mi1345p c
is: CHEBI:57895
is: SBO:0000247
initial amount: NaN
is: HMDB01059
boundary condition: false
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
initial concentration: 1.0
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_8cfa349a_ba1d_42e0_8df2_2fed9a98fd02
has only substance units: false
initial concentration: NaN
is encoded by: hsa:48
is: SBO:0000252
type: Species
is: P21399
constant: false
boundary condition: true
initial amount: NaN
name: ACO1

metaR ADKd
is described by: ECO:0000269
fast: false
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
type: Reaction
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.4.3
name: adenylate kinase (d form)
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_508c67fd_e500_4f5d_8b0b_5dd6f99eed44
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P26439
has only substance units: false
is encoded by: hsa:3284
type: Species
name: HSD3B2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_da1c66d9_fea6_4c55_9be5_56e4e22a2818
constant: false
is: Q86VQ6
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:114112
is: SBO:0000252
name: TXNRD3
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_7e81247f_9e66_4567_9dd7_d81de7c91c76
initial amount: NaN
boundary condition: true
is: SBO:0000297
type: Species
name: SLC7A11:SLC3A2
has part: Q9UPY5
is encoded by: hsa:23657
initial concentration: NaN
has only substance units: false
constant: false

metaR r0840
is: SBO:0000185
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.14.13.70
type: Reaction
product: MODEL1310110055#
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
reversible: true
fast: false
is described by: ECO:0000000
name: Free diffusion

metaM HC01609 e
constant: false
is: SBO:0000247
name: UroporphyrinogenI
initial amount: NaN
is: CHEBI:28766
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
initial concentration: 1.0

metaR FAOXC1811603m
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110055#
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110055#
name: Beta oxidation fatty acid
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_9ae6a19c_01a7_42e8_9f32_aeec6dbd70ca
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2109
name: ETFA:ETFB
is: SBO:0000297
has part: P38117
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_53b7cb31_f689_42c7_a8b8_d70b5317cf2b
name: SULT1A1
constant: false
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6817
initial concentration: NaN

metaR OROTGLUt
is: SBO:0000185
is described by: ECO:0000134
name: OROTGLUt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reversible: true
product: MODEL1310110055#
kinetic law: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#

metaM mev R c
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:36464
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
is: HMDB00227
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
name: (R)-mevalonate

http://identifiers.org/biomodels.db/MODEL1310110055#_9bacdf9f_dfbc_4147_af9c_58ccb5f1f54e
constant: false
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:5315
initial concentration: NaN
name: PKM2
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110055#_b60598cf_e50c_46e7_a2b4_d8135fd2727b
initial amount: NaN
name: SLC7A11
is: Q9UPY5
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:23657

metaR r0594
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.2.1.3
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
kinetic law: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110055#
reversible: true
product: MODEL1310110055#

metaM udpg r
initial amount: NaN
boundary condition: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: HMDB00286
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: CHEBI:58367
is: SBO:0000247
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate

metaR NDP10ex
type: Reaction
kinetic law: MODEL1310110055#
is: SBO:0000176
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
modifier: MODEL1310110055#
reactant: MODEL1310110055#
product: MODEL1310110055#
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.6
name: nucleoside-diphosphatase (IDP), extracellular
is described by: ECO:0000269
fast: false

metaM 2ddecdicoa x
constant: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
name: 2,6-dodecadienoylcoa
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB11123
is: SBO:0000247
initial amount: NaN
is: C05279
type: Species

metaM 1p3h5c c
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: HMDB01369
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
is: CHEBI:6151
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_96444eb3_3ab4_454b_95c7_e342d480feae
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:AI191472
is: SBO:0000252
name: _AI191472_1_c
boundary condition: true
has only substance units: false
constant: false

metaM occoa c
initial concentration: 1.0
is: HMDB01070
is: SBO:0000247
constant: false
boundary condition: false
type: Species
is: C01944
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
initial amount: NaN
has only substance units: false
name: Octanoyl-CoA (n-C8:0CoA)
is: CHEBI:57386

metaM andrstndn r
notes: FORMULA: C19H26O2 CHARGE: 0 INCHI: InChI=1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00280
is: SBO:0000247
name: androst-4-ene-3,17-dione
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:16422
constant: false
is: HMDB00053
type: Species

metaM arachdcrn m
constant: false
initial concentration: 1.0
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: CHEBI:57387
type: Species
boundary condition: false
initial amount: NaN
name: C20:4 carnitine
has only substance units: false
is: HMDB01322
is: SBO:0000247

metaR r2364
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110055#

metaR PI4PLCn
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
fast: false
type: Reaction
name: phosphatidylinositol 4-phosphate phospholipase C, nucleus
is version of: http://identifiers.org/ec-code/3.1.4.11
reactant: MODEL1310110055#
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000176

metaR PPDOy
is version of: http://identifiers.org/ec-code/1.1.1.2
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
reactant: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.21
product: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
kinetic law: MODEL1310110055#
is described by: ECO:0000269
reversible: false
fast: false
modifier: MODEL1310110055#

metaM cysam c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: cysteaminium
boundary condition: false
is: SBO:0000247
is: HMDB02991
constant: false
type: Species
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
is: CHEBI:58029

metaR ILEtec
fast: false
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reversible: true
name: L-isoleucine transport via diffusion (extracellular to cytosol)
product: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is: SBO:0000185
reactant: MODEL1310110055#
is described by: ECO:0000269

metaR GALASE10ly
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
modifier: MODEL1310110055#
reactant: MODEL1310110055#
reversible: false
is described by: ECO:0000000

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_5b04dbb3_2b48_4bd4_8744_e23a52e40957
type: Species
initial concentration: NaN
is encoded by: hsa:10965
has only substance units: false
name: ACOT2
boundary condition: true
constant: false
initial amount: NaN
is: P49753
is: SBO:0000252

metaM triodthy e
is: SBO:0000247
constant: false
is: HMDB00265
initial concentration: 1.0
type: Species
is: CHEBI:18258
boundary condition: false
name: 3,3',5-triiodo-L-thyronine
initial amount: NaN
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465

http://identifiers.org/biomodels.db/MODEL1310110055#_487309a0_a9b5_42ea_86b6_148efccb5ed7
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:39
is: Q9BWD1
name: ACAT2

metaM dc2coa x
boundary condition: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
name: trans-Dec-2-enoyl-CoA
is: HMDB01168

metaR NAtx
fast: false
kinetic law: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
reversible: true
is: SBO:0000185
type: Reaction
name: sodium transport via diffusion (perioxisome)
reactant: MODEL1310110055#
product: MODEL1310110055#

metaM adp n
is: CHEBI:456216
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial amount: NaN
is: SBO:0000247
name: ADP(3-)
is: HMDB01341
type: Species
boundary condition: false

metaR PPDOx
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD
kinetic law: MODEL1310110055#
is described by: ECO:0000269
modifier: MODEL1310110055#
reversible: false
name: Propane-1,2-diol:NAD+ 1-oxidoreductase
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_d0449a36_3474_4513_9a58_43dd4d04c82b
initial concentration: NaN
name: SLC13A2
is: E7ETH5
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:9058

http://identifiers.org/biomodels.db/MODEL1310110055#_8f31c929_93cf_4eb8_893d_47f763628ac7
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q14032
constant: false
type: Species
name: BAAT
initial concentration: NaN
is encoded by: hsa:570
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_b87d4f28_b833_4fd6_a617_dfd2e5e8f6ae
constant: false
initial concentration: NaN
is encoded by: hsa:54677
is: E7EQF2
type: Species
name: CROT
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR r2363
kinetic law: MODEL1310110055#
reversible: true
type: Reaction
name: Organic anion transporter 5 Utilized transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110055#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110055#

metaR DSAT
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
name: dihydrosphingosine N-acyltransferase
type: Reaction
product: MODEL1310110055#
fast: false
is: SBO:0000176
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000000
reversible: false

metaR FUCASEe
product: MODEL1310110055#
name: alpha-fucosidase, extracellular
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.51
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110055#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_9ebdf0d4_ba27_4d14_8151_0f32a16e05d4
type: Species
name: PDE7A
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:5150
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_46268b56_ba21_4f88_81e3_6b5bd3447030
is encoded by: hsa:5223
is: SBO:0000252
initial concentration: NaN
is: P18669
name: PGAM1
has only substance units: false
boundary condition: true
constant: false
type: Species
initial amount: NaN

metaR r0027
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
reversible: true
kinetic law: MODEL1310110055#
is: SBO:0000176
fast: false
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.14.13.39
modifier: MODEL1310110055#

metaR EX thmmp LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiamin monophosphate exchange
type: Reaction

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaM CE5786 e
constant: false
is: HMDB02710
type: Species
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
initial amount: NaN
is: CHEBI:27485
is: SBO:0000247
has only substance units: false
boundary condition: false
name: kinetensin
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_51634764_fde7_406c_80e2_4def6d5d40aa
boundary condition: true
name: PGM1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is: B4DPV0
type: Species
is encoded by: hsa:5236

metaR r2362
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
fast: false
reactant: MODEL1310110055#
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110055#
kinetic law: MODEL1310110055#

metaM HC01401 x
initial amount: NaN
name: (S)-3-Hydroxydodecanoyl-CoA
is: CHEBI:27668
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
has only substance units: false

metaM adp m
constant: false
boundary condition: false
is: HMDB01341
initial concentration: 1.0
initial amount: NaN
name: ADP
is: C00008
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/3310
is: CHEBI:456216
has only substance units: false

metaR SUCCt4 2
is described by: ECO:0000269
modifier: MODEL1310110055#
name: succinate transport via sodium symport
fast: false
kinetic law: MODEL1310110055#
is: SBO:0000185
product: MODEL1310110055#
reversible: true
reactant: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD

metaM ksii core4 e
is: CHEBI:17268
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: HMDB00211
name: keratan sulfate II (core 4-linked)

metaM HC01407 m
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
initial concentration: 1.0
constant: false
is: CHEBI:28276
name: (S)-Hydroxyhexanoyl-CoA
is: SBO:0000247
has only substance units: false

metaR B3GNT11g
reversible: false
is described by: ECO:0000269
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (10678.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
reactant: MODEL1310110055#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110055#
modifier: MODEL1310110055#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_348637db_55bb_45d5_8d2c_5a97ed0dbd3b
is: Q9NRF8
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:56474
name: CTPS2
boundary condition: true
type: Species
initial amount: NaN
constant: false

metaR r0591
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
is: SBO:0000176
modifier: MODEL1310110055#
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
reversible: true
product: MODEL1310110055#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
type: Reaction

metaM triodthy c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00265
constant: false
type: Species
is: CHEBI:18258
name: 3,3',5-triiodo-L-thyronine
has only substance units: false
initial amount: NaN
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465

http://identifiers.org/biomodels.db/MODEL1310110055#_db83c3f2_805e_46ac_a88b_6bcaf747ca32
name: FAH
is encoded by: hsa:2184
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P16930

metaM succ x
initial concentration: 1.0
type: Species
is: C00042
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:30031
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
constant: false
is: HMDB00254
name: Succinate
has only substance units: false

metaR r2361
is: SBO:0000185
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110055#
product: MODEL1310110055#
kinetic law: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_d3fcea5b_7b05_4fa8_83d2_ab0b4c7e4c8f
is encoded by: hsa:2639
is: SBO:0000252
type: Species
has only substance units: false
constant: false
name: GCDH
is: Q92947
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaM gacpail hs r
type: Species
name: glucosaminyl-acylphosphatidylinositol
constant: false
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: HMDB01401
is: C00092
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:61548
initial concentration: 1.0
is: SBO:0000247

metaM dtdp e
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
initial concentration: 1.0
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB01274
is: CHEBI:58369
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_96691911_6d1d_4921_b134_f519af4ca719
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:NM 013421
name: _NM_013421_1_e
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_b4af06f2_5a84_47dc_8bda_3bef85481bc0
is encoded by: hsa:226
is: P04075
has only substance units: false
initial concentration: NaN
type: Species
name: ALDOA
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM m4mpdol L c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
initial concentration: 1.0
is: CHEBI:37633
boundary condition: false
constant: false
initial amount: NaN
type: Species
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog

metaR r2368
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110055#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
reactant: MODEL1310110055#
is described by: ECO:0000000

metaR P45027A1m
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
is: SBO:0000176
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
fast: false
name: Cytochrome P450 27

metaR SBTR
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.21
is described by: ECO:0000269
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
name: D-sorbitol reductase
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#

metaM pi x
name: hydrogenphosphate
is: HMDB00973
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaR r2142
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110055#
fast: false
reactant: MODEL1310110055#

metaM gd3 hs g
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
name: GD3
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:28424

metaM dmnoncrn x
notes: FORMULA: C18H37NO4 CHARGE: 0
initial amount: NaN
is: SBO:0000247
name: 4,8-dimethylnonanoyl carnitine
constant: false
boundary condition: false
is: HMDB06202
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_251c5368_d7a0_4cc1_b083_930d5645f168
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
constant: false
name: GALNT4
is encoded by: hsa:8693
is: SBO:0000252
has only substance units: false
is: Q8N4A0

metaR DOLPMT1 Ler
type: Reaction
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
reversible: false
modifier: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.258
kinetic law: MODEL1310110055#
product: MODEL1310110055#

metaR AIRCr
is: SBO:0000176
name: phosphoribosylaminoimidazole carboxylase
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/6.3.2.6
reversible: true
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_3120828f_e34c_4741_85b3_18063641acb6
initial amount: NaN
name: GNPDA2
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:132789
is: Q8TDQ7
has only substance units: false

metaR RE1447N
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
is: SBO:0000176
fast: false
name: RE1447
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
is described by: ECO:0000000

metaR C12DCTD
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Dodecanedioic acid by diffusion
type: Reaction

metaM thm c
initial amount: NaN
is: HMDB00235
initial concentration: 1.0
type: Species
is: C00378
boundary condition: false
name: Thiamin
constant: false
notes: FORMULA: C12H17N4OS CHARGE: 1
is: CHEBI:0
has only substance units: false
is: SBO:0000247

metaR r2367
kinetic law: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110055#
is described by: ECO:0000000
fast: false
reversible: true

metaR r2141
product: MODEL1310110055#
modifier: MODEL1310110055#
is: SBO:0000185
fast: false
reactant: MODEL1310110055#
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110055#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM uri c
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:16704
is: HMDB00296
name: Uridine
is: C00299
has only substance units: false

metaM adp r
is: CHEBI:456216
type: Species
is: SBO:0000247
is: HMDB01341
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
name: ADP(3-)
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
boundary condition: false

metaM pcrn x
is: HMDB00824
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
initial concentration: 1.0
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/107738
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
name: propionyl-carnitine

metaM tetdece1crn c
boundary condition: false
initial amount: NaN
constant: false
type: Species
name: tetradecenoyl carnitine
is: HMDB02014
initial concentration: 1.0
notes: FORMULA: C21H39NO4 CHARGE: 0
is: SBO:0000247
has only substance units: false

metaR RTOTAL2t
is described by: ECO:0000000
name: RTOTAL2 transport
is: SBO:0000185
reactant: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
reversible: true
kinetic law: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:

metaM 2mop m
name: 2-methyl-3-oxopropanoate
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial concentration: 1.0
constant: false
is: HMDB01172
is: SBO:0000247
is: CHEBI:57700

metaR r0596
modifier: MODEL1310110055#
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
kinetic law: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
fast: false
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110055#

metaM 3hmp m
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
is: CHEBI:11805
name: 3-hydroxy-2-methylpropanoate
type: Species
is: HMDB00023
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_3531949d_bb5a_4a5b_87eb_4e83bba41db1
initial amount: NaN
type: Species
is encoded by: hsa:514
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
name: ATP5E

http://identifiers.org/biomodels.db/MODEL1310110055#_a41ea2e0_6f1d_417d_aec3_b62b5f2ceef2
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: MTMR3
is encoded by: hsa:8897
is: SBO:0000252
initial concentration: NaN
constant: false

metaR RE1447M
reversible: true
reactant: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
is: SBO:0000176
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.3.1.41
type: Reaction
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000000
name: RE1447

metaM 3octdece1coa c
is: HMDB00712
name: 3-hydroxyoctadecenoylcoa
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
type: Species

metaR r2366
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110055#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110055#
product: MODEL1310110055#
name: Organic anion transporter 5 Utilized transport

metaR r2140
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110055#
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110055#
type: Reaction
reversible: true
product: MODEL1310110055#
is: SBO:0000185
fast: false

metaM nh4 e
is: CHEBI:28938
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: HMDB00051
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
has only substance units: false
name: ammonium

http://identifiers.org/biomodels.db/MODEL1310110055#_a5376bdd_22c7_4557_b09a_2057be8b55c3
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
name: SLC17A2
initial concentration: NaN
is: O00624
has only substance units: false
boundary condition: true
is encoded by: hsa:10246

metaM g3pc c
is: CHEBI:16870
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
name: sn-Glycero-3-phosphocholine
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670
initial amount: NaN
type: Species
is: HMDB00086

metaM saccrp L m
notes: FORMULA: C11H19N2O6 CHARGE: -1 INCHI: InChI=1S/C11H20N2O6/c12-7(10(16)17)3-1-2-6-13-8(11(18)19)4-5-9(14)15/h7-8,13H,1-6,12H2,(H,14,15)(H,16,17)(H,18,19)/p-1/t7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00363
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: L-saccharopinate(1-)
is: HMDB00279
is: CHEBI:57951
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM r5p r
is: CHEBI:18189
constant: false
type: Species
is: HMDB00618
is: SBO:0000247
has only substance units: false
name: alpha-D-Ribose 5-phosphate
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117

metaM octd11ecoa m
is: HMDB06294
boundary condition: false
name: 11-octadecenoylcoa
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR MM8Cg
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is described by: ECO:0000000
kinetic law: MODEL1310110055#
reversible: false
product: MODEL1310110055#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
modifier: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.113

metaM glyb c
name: glycine betaine
constant: false
is: HMDB00043
has only substance units: false
is: CHEBI:17750
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110055#_074c9372_1feb_45ad_9e91_0f28a0585103
initial amount: NaN
is encoded by: hsa:AA419122
constant: false
name: _AA419122_1_c
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_2bc4b548_0561_4677_b21b_2dda67acdb77
type: Species
boundary condition: true
constant: false
is encoded by: hsa:1603
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: DAD1
is: Q53G02

metaR r0022
is described by: ECO:0000000
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
type: Reaction
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.8.1.7
product: MODEL1310110055#
fast: false
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110055#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7

metaR NACHEXA20ly
kinetic law: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110055#
is described by: ECO:0000000
product: MODEL1310110055#
reversible: false

metaM ksii core2 deg6 l
name: keratan sulfate II (core 2-linked), degradation product 6
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB00143
notes: FORMULA: C44H72N4O33SX CHARGE: -1
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:12936

metaR FERO
product: MODEL1310110055#
type: Reaction
fast: false
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000176
reversible: false
is described by: ECO:0000134
name: ferroxidase
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
modifier: MODEL1310110055#

metaR r2365
is described by: ECO:0000000
product: MODEL1310110055#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
reversible: true

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_e1d81f12_34c6_4991_bb66_d52e3b7bca10
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:2235
name: FECH
type: Species
is: P22830
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM ura e
name: uracil
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
initial concentration: 1.0
is: CHEBI:17568
is: SBO:0000247
type: Species
constant: false
is: HMDB00300
has only substance units: false
boundary condition: false
initial amount: NaN

metaR RE1691M
reactant: MODEL1310110055#
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.8.1.1
is: SBO:0000176
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
name: RE1691
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110055#
fast: false

metaM hexe3coa x
has only substance units: false
is: HMDB06522
constant: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
boundary condition: false
name: 3-hexenoylcoa
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species

metaM ppp9 m
notes: FORMULA: C34H32N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00905 EHMN_ABBREVIATION: C02191
initial amount: NaN
type: Species
is: HMDB00241
constant: false
has only substance units: false
is: CHEBI:36159
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: Protoporphyrin

metaM aicar e
notes: FORMULA: C9H13N4O8P CHARGE: -2
constant: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
boundary condition: false
is: CHEBI:58475
type: Species
has only substance units: false
is: HMDB01517
initial amount: NaN
is: C04677
is: SBO:0000247
initial concentration: 1.0

metaR UDPGLCAter
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
modifier: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
type: Reaction
fast: false
reversible: true
is: SBO:0000185

metaR EX c51crn
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

metaR HEX10
product: MODEL1310110055#
is described by: ECO:0000212
fast: false
reactant: MODEL1310110055#
name: hexokinase (D-glucosamine:ATP)
reversible: false
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.2
is version of: http://identifiers.org/ec-code/2.7.1.1
type: Reaction
notes: GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.

http://identifiers.org/biomodels.db/MODEL1310110055#_68ea42eb_8e72_4d96_9908_efed956b6e4c
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P50225
type: Species
name: SULT1A1
is encoded by: hsa:6817
constant: false
has only substance units: false
boundary condition: true

metaM 4hglusa m
is: SBO:0000247
is: HMDB06556
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:27809
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
boundary condition: false
initial amount: NaN
name: L-4-hydroxyglutamic semialdehyde
has only substance units: false

metaM ppbng c
is: C00931
constant: false
boundary condition: false
notes: FORMULA: C10H13N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00588 EHMN_ABBREVIATION: C00931
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
name: Porphobilinogen
is: HMDB00245
initial concentration: 1.0
is: CHEBI:58126

metaR FUMm
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
type: Reaction
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/4.2.1.2
is described by: ECO:0000134
name: fumarase, mitochondrial
reversible: true
product: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110055#_f9e15517_f94b_449f_b6ed_f7a955a2a2bc
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:55825
name: PECR
initial concentration: NaN
is: Q9BY49
type: Species
boundary condition: true
is: SBO:0000252

metaR PYNP2r
fast: false
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
reactant: MODEL1310110055#
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.4.2.3
reversible: true
name: pyrimidine-nucleoside phosphorylase (uracil)

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaM 3ivcrn e
is: HMDB02068
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: 3-hydroxy-isovaleryl carnitine
constant: false
notes: FORMULA: C12H23NO5 CHARGE: 0

metaR EX tetdec2crn
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecadienoyl carnitine
type: Reaction

metaM udpg c
is: CHEBI:58367
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: SBO:0000247
is: HMDB00286
constant: false
boundary condition: false
type: Species
is: C00029
initial concentration: 1.0
name: UDPglucose
has only substance units: false
initial amount: NaN

metaR r0556
type: Reaction
fast: false
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
reactant: MODEL1310110055#
reversible: true
modifier: MODEL1310110055#
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.14.19.1
is: SBO:0000176
kinetic law: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:

metaR EX 3ivcrn
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-isovaleryl carnitine
type: Reaction

metaM 5fthf c
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
name: 5-formyltetrahydrofolate(2-)
is: HMDB01562
type: Species
has only substance units: false
is: CHEBI:57457
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_a0b09e41_387d_4158_a5f1_505593e41612
initial amount: NaN
is encoded by: hsa:2876
initial concentration: NaN
type: Species
name: GPX1
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false

metaR r0331
modifier: MODEL1310110055#
is described by: ECO:0000000
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reversible: false
is: SBO:0000176
type: Reaction
fast: false

metaR O2Stx
type: Reaction
name: superoxide anion transport via diffusion (peroxisome)
kinetic law: MODEL1310110055#
is: SBO:0000185
reactant: MODEL1310110055#
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaR CRNtx
name: carnitine transport peroxisome to mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
is described by: ECO:0000000
product: MODEL1310110055#
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_0af361f7_2f26_4108_9868_5c63ac8f1429
type: Species
is: SBO:0000252
is: P24311
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
name: COX7B
is encoded by: hsa:1349
initial amount: NaN

metaR r2137
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
modifier: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
type: Reaction

metaR DINt
reactant: MODEL1310110055#
is: SBO:0000185
product: MODEL1310110055#
name: deoxyinosine transport via diffusion
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_c9628c89_b762_4522_8317_45d2cdfbae2a
type: Species
is: Q9GZX3
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4166
name: CHST6
initial concentration: NaN
constant: false

metaM accoa c
is: C00024
boundary condition: false
is: HMDB01206
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial amount: NaN
is: CHEBI:57288
name: Acetyl-CoA
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_42f3eafc_95e3_47ed_84a2_c6ae78daa666
has only substance units: false
name: IDH1
type: Species
initial amount: NaN
is encoded by: hsa:3417
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is: O75874

metaR KSII CORE4t
name: keratan sulfate II (core4) transport, golgi to extracellular
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
product: MODEL1310110055#
reactant: MODEL1310110055#

metaR B3GNT51g
type: Reaction
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reversible: false
reactant: MODEL1310110055#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
modifier: MODEL1310110055#
is described by: ECO:0000304
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (84002.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ

metaM chsterol c
has only substance units: false
is: HMDB00067
name: cholesterol
constant: false
initial amount: NaN
is: CHEBI:16113
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

metaR VACCCRNt
modifier: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
is described by: ECO:0000269
name: transport into the mitochondria (carnitine)
product: MODEL1310110055#
reactant: MODEL1310110055#

metaR IVCOAACBP
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Isovaleryl-CoA from mitochondria into cytosol
type: Reaction

metaM 3ivcrn c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C12H23NO5 CHARGE: 0
is: http://identifiers.org/pubchem.compound/11966188
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: C05998
is: HMDB06870
constant: false
name: 3-hydroxy-isovaleryl carnitine
type: Species

metaM uacgam c
is: HMDB00290
has only substance units: false
type: Species
constant: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: SBO:0000247
boundary condition: false
is: CHEBI:57705
initial amount: NaN
initial concentration: 1.0

metaR HPYRRy
is version of: http://identifiers.org/ec-code/1.1.1.79
fast: false
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:2689175,PMID:9038835 NOTES:JLR
name: Hydroxypyruvate reductase (NADPH)
is described by: ECO:0000269
product: MODEL1310110055#
modifier: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000176
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_9e3c37f8_5aa2_4866_a4ea_05182e26f372
is encoded by: hsa:2618
name: GART
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q59HH3
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110055#_ba19540a_a94b_44db_9a2e_6bebfa6e2871
initial amount: NaN
name: HSD17B7
is: P56937
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:51478
boundary condition: true
constant: false

metaM CE5117 m
is: CHEBI:57923
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_9cf43af8_f849_47e5_9a8d_614fbf847c4f
boundary condition: true
is encoded by: hsa:23563
has only substance units: false
type: Species
constant: false
initial concentration: NaN
name: CHST5
initial amount: NaN
is: SBO:0000252
is: Q9GZS9

metaR r0558
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
modifier: MODEL1310110055#
fast: false
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
reactant: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000176
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.5.1.3
is described by: ECO:0000000
reversible: true
type: Reaction

metaM dhf c
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial amount: NaN
is: HMDB01056
has only substance units: false
name: 7,8-Dihydrofolate
is: CHEBI:57451
is: C00415
initial concentration: 1.0
constant: false

metaR NDPK1n
reversible: true
is: SBO:0000176
reactant: MODEL1310110055#
product: MODEL1310110055#
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
fast: false
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.

metaR r2131
fast: false
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000185
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110055#

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

metaR PA HStn
is described by: ECO:0000000
kinetic law: MODEL1310110055#
reversible: true
fast: false
reactant: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000185
type: Reaction
name: phosphatidate transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR Htx
reversible: true
kinetic law: MODEL1310110055#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110055#
name: H transporter, peroxisome
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
type: Reaction

metaM dmhptcoa m
initial concentration: 1.0
type: Species
name: 2,6 dimethylheptanoyl-CoA
constant: false
boundary condition: false
is: HMDB06258
has only substance units: false
notes: FORMULA: C30H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C30H52N7O17P3S/c1-17(2)7-6-8-18(3)29(42)58-12-11-32-20(38)9-10-33-27(41)24(40)30(4,5)14-51-57(48,49)54-56(46,47)50-13-19-23(53-55(43,44)45)22(39)28(52-19)37-16-36-21-25(31)34-15-35-26(21)37/h15-19,22-24,28,39-40H,6-14H2,1-5H3,(H,32,38)(H,33,41)(H,46,47)(H,48,49)(H2,31,34,35)(H2,43,44,45)/p-4/t18-,19+,22-,23-,24?,28+/m0/s1
is: SBO:0000247
initial amount: NaN

metaM CE2420 m
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
constant: false
is: HMDB11123
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:28387
boundary condition: false
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_42595e6c_d80e_46f9_98b8_c515b70ef017
boundary condition: true
name: _BE042354_1_m
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:BE042354
initial amount: NaN
type: Species

metaR ADK1m
reactant: MODEL1310110055#
name: adenylate kinase, mitochondrial
fast: false
is: SBO:0000176
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
modifier: MODEL1310110055#
reversible: true
product: MODEL1310110055#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_177095a2_2173_423f_9b40_9d14ad6204b1
constant: false
has only substance units: false
is: SBO:0000252
name: DGKH
is: Q86XP1
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:160851

metaR P45019A2r
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.14.1
modifier: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (1588.1) or (1588.2) SUBSYSTEM: Steroid metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:2208160 NOTES:human aromatase cDNA transfected cell lines used and kinetic properties described with tritiated androstenedione as substrate
fast: false
kinetic law: MODEL1310110055#
name: aromatase
reversible: false

metaM 34dhoxmand c
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
initial concentration: 1.0
is: CHEBI:27637
initial amount: NaN
is: HMDB01866
constant: false
name: 3,4-Dihydroxymandelate
has only substance units: false

metaR NDPK1m
reactant: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
product: MODEL1310110055#
fast: false
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction

metaM ha e
is: CHEBI:16336
name: hyaluronan
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
initial concentration: 1.0

metaM chsterol e
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
name: cholesterol
is: CHEBI:16113
type: Species
is: SBO:0000247
is: HMDB00067
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

metaR GLNLASEer
is: SBO:0000176
is described by: ECO:0000000
name: gluconolactonase, endoplasmic reticulum
kinetic law: MODEL1310110055#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110055#_db8b81c6_a68a_487d_a546_c77b64090c7d
initial amount: NaN
type: Species
is encoded by: hsa:23236
is: SBO:0000252
initial concentration: NaN
name: PLCB1
boundary condition: true
has only substance units: false
constant: false

metaR r0552
is version of: http://identifiers.org/ec-code/1.3.5.1
reactant: MODEL1310110055#
product: MODEL1310110055#
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
type: Reaction
fast: false
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000000

metaR BDMT L
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (liver)
fast: false
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
product: MODEL1310110055#
reactant: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000000
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.142

metaR DM T antigen g
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaR r2132
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110055#
reversible: true
kinetic law: MODEL1310110055#
is described by: ECO:0000000
modifier: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000185

metaR S4TASE2ly
modifier: MODEL1310110055#
is described by: ECO:0000000
kinetic law: MODEL1310110055#
reversible: true
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.1.6.12
name: N-acetylgalactosamine-4-sulfatase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
product: MODEL1310110055#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110055#_0ff60ee1_55f8_44a0_ab3a_047b9d3eeafb
has only substance units: false
is: P51648
initial concentration: NaN
is encoded by: hsa:224
name: ALDH3A2
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species

metaR FUCASE2ly
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.2.1.51
modifier: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
name: alpha-fucosidase, lysosomal
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110055#_b76babd9_835d_4fcc_a26c_8dde518990e1
boundary condition: true
constant: false
is encoded by: hsa:29922
type: Species
is: SBO:0000252
has only substance units: false
is: Q9Y5B8
initial amount: NaN
initial concentration: NaN
name: NME7

metaM cpppg3 c
has only substance units: false
is: HMDB01261
is: SBO:0000247
constant: false
name: Coproporphyrinogen III
type: Species
notes: FORMULA: C36H40N4O8 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01085 EHMN_ABBREVIATION: C03263
initial concentration: 1.0
is: C03263
boundary condition: false
is: CHEBI:57309
initial amount: NaN

metaM 13dpg c
is: SBO:0000247
type: Species
name: 3-Phospho-D-glyceroyl phosphate
initial amount: NaN
is: CHEBI:57604
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB01270
is: http://identifiers.org/pubchem.compound/3535
is: C00236
boundary condition: false

metaR SUCD1m
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.3.5.1
fast: false
name: succinate dehydrogenase
type: Reaction
is: SBO:0000176
reactant: MODEL1310110055#
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
reversible: true
kinetic law: MODEL1310110055#
is described by: ECO:0000134

metaM xol7ah2al c
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB06894
type: Species
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: SBO:0000247
is: CHEBI:27428
has only substance units: false

metaR NDP7er
reversible: false
fast: false
product: MODEL1310110055#
is: SBO:0000176
kinetic law: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110055#
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum

metaM aicar c
initial amount: NaN
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
is: CHEBI:58475
type: Species
is: SBO:0000247
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
boundary condition: false
initial concentration: 1.0
is: HMDB01517
constant: false
is: C04677
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_70a788fc_9eef_4b27_b06b_03de4a2ff9bb
initial concentration: NaN
type: Species
has only substance units: false
name: ENTPD3
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:956
constant: false
boundary condition: true
is: O75355

metaR r2133
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reversible: true
is: SBO:0000185
reactant: MODEL1310110055#
type: Reaction
fast: false
product: MODEL1310110055#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000

metaR CERT1gt
name: ceramide transport protein
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
is: SBO:0000185
is described by: ECO:0000304
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
product: MODEL1310110055#
modifier: MODEL1310110055#
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#

metaR r0553
is described by: ECO:0000000
reactant: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
kinetic law: MODEL1310110055#
reversible: true
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
fast: false
is: SBO:0000176

metaR CYSASNNaEx
reactant: MODEL1310110055#
type: Reaction
product: MODEL1310110055#
fast: false
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110055#_e0743f8a_7f38_40e2_80c4_ace25eae250a
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
name: SULT1A1
is encoded by: hsa:6817
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_732e9940_116d_40a8_8c87_2487802fdc04
is encoded by: hsa:81537
constant: false
name: SGPP1
is: Q9BX95
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN

metaM btcoa c
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
is: HMDB01088
has only substance units: false
constant: false
initial amount: NaN
name: Butanoyl-CoA
is: CHEBI:57371
is: C00136
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species

metaM ddcacoa c
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB03571
is: CHEBI:57375
is: C01832
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
constant: false
name: Dodecanoyl-CoA (n-C12:0CoA)
initial concentration: 1.0

metaR ESTRADIOLtr
is described by: ECO:0000000
name: estradiol intracellular transport
kinetic law: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000185
fast: false
reversible: true

metaR DOLPMT2 Ler
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110055#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
is: SBO:0000176
kinetic law: MODEL1310110055#
product: MODEL1310110055#

metaR AG13T9g
modifier: MODEL1310110055#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_7aacd787_c274_4546_98c2_ad7d40204a2f
has only substance units: false
is: Q13057
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:80347
name: COASY
is: SBO:0000252
constant: false

metaR EX arachcoa LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: arachidyl coenzyme A exchange
type: Reaction

metaM acmana c
is: SBO:0000247
constant: false
initial concentration: 1.0
name: N-acetyl-D-mannosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
is: HMDB01129
is: CHEBI:17122
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species

metaM hs deg11 l
is: HMDB00868
notes: FORMULA: C55H81N3O67S7 CHARGE: -8
is: CHEBI:57737
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: heparan sulfate, degradation product 11
has only substance units: false

metaM l2n2m2mn l
initial concentration: 1.0
constant: false
boundary condition: false
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
is: SBO:0000247
notes: FORMULA: C54H91N3O41 CHARGE: 0
type: Species
initial amount: NaN
is: CHEBI:12936
has only substance units: false
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110055#_e31acc6f_fbfd_4c38_88d2_6fdd4f894828
boundary condition: true
is: Q99643
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
name: SDHC
is encoded by: hsa:6391

http://identifiers.org/biomodels.db/MODEL1310110055#_99108be0_874e_4795_a42c_d0de3fb70e24
has only substance units: false
boundary condition: true
is encoded by: hsa:4697
is: O00483
type: Species
constant: false
initial amount: NaN
name: NDUFA4
is: SBO:0000252
initial concentration: NaN

metaM cmpacna g
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:57812
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
name: CMP-N-acetyl-beta-neuraminate(2-)
type: Species
is: HMDB01176
boundary condition: false
has only substance units: false

metaM uacgam g
initial concentration: 1.0
is: HMDB00290
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: CHEBI:57705
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_aab7d252_8a80_4b4a_a4bb_ea8494b01ba1
is encoded by: hsa:6390
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: SDHB
is: P21912
has only substance units: false
initial concentration: NaN
constant: false

metaR HMGCOAtx
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
is: SBO:0000185
reversible: true
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_3a7616ce_ef48_4708_bbac_6f2aea882aa8
is encoded by: hsa:4720
has part: Q6IBC4
is: SBO:0000297
is encoded by: hsa:4728
is encoded by: hsa:4697
has part: O95168
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
initial amount: NaN
has part: P28331
has part: E5KNH5
has part: A8K761
is encoded by: hsa:4537
is encoded by: hsa:4717
is encoded by: hsa:4702
is encoded by: hsa:4700
has part: O14561
is encoded by: hsa:4704
has part: B7Z792
is encoded by: hsa:4708
has part: O95299
has part: P03915
has part: Q16795
is encoded by: hsa:4707
has part: O75251
has part: O75438
is encoded by: hsa:126328
has only substance units: false
has part: O43677
has part: O00217
has part: O43678
has part: O00483
has part: H7C5B8
has part: Q549M5
has part: O95169
has part: F8VQS7
is encoded by: hsa:4698
is encoded by: hsa:4726
constant: false
is encoded by: hsa:4696
is encoded by: hsa:4706
is encoded by: hsa:4725
is encoded by: hsa:4695
is encoded by: hsa:4723
has part: Q6IB80
has part: Q85KV6
has part: P03897
has part: P03905
has part: Q6IBA0
is encoded by: hsa:4714
has part: Q9P0J0
is encoded by: hsa:4712
has part: Q16718
is encoded by: hsa:4716
has part: O43181
has part: Q6IBB5
has part: P56181
is encoded by: hsa:4722
is encoded by: hsa:4536
has part: B1AM93
has part: O95167
has part: Q13454
is encoded by: hsa:4540
is encoded by: hsa:4729
boundary condition: true
has part: P17568
has part: P56556
has part: Q9Y6M9
is encoded by: hsa:4731
has part: Q7GXY9
is encoded by: hsa:4539
is encoded by: hsa:4710
is encoded by: hsa:4724
is encoded by: hsa:4694
has part: P19404
is encoded by: hsa:4538
is encoded by: hsa:4718
is encoded by: hsa:4701
has part: C9JT23
is encoded by: hsa:4705
has part: Q6FG42

metaR r0836
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.16
fast: false
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: SBO:0000185
modifier: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true

metaR r1609
fast: false
kinetic law: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110055#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction

metaR BMTer L
reversible: false
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110055#
name: B mannosyltransferase, endoplasmic reticulum
is: SBO:0000176
reactant: MODEL1310110055#
type: Reaction
fast: false
modifier: MODEL1310110055#

metaR PALFATPtc
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

metaR CTPtn
name: CTP diffusion in nucleus
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000000
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_331352bc_5f8a_4edd_b461_cb0a4efb9170
name: _H77542_1_r
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:H77542
constant: false
boundary condition: true

metaM xol7ah2al m
is: HMDB06894
boundary condition: false
is: CHEBI:27428
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
initial amount: NaN
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445

http://identifiers.org/biomodels.db/MODEL1310110055#_17ea0887_f557_4767_80f9_6d4ada1733e3
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6489
name: ST8SIA1
is: Q92185
boundary condition: true
constant: false

metaR HSD17B7r
fast: false
notes: GENE_ASSOCIATION: (51478.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 4 AUTHORS: PMID:12732193 NOTES:Recombinant cDNA from human granulosa cells were purified and used in an enzyme assay, Km and Kcat values quantified
type: Reaction
name: testicular 17-beta-hydroxysteroid dehydrogenase
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
reversible: false
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.1.1.62
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_a71d57fd_ab27_4f4e_bc85_df598b97a2b7
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:50484
constant: false
is: Q7LG56
has only substance units: false
initial amount: NaN
name: RRM2B

metaM ttdca c
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
is: HMDB00806
name: myristate
boundary condition: false
is: CHEBI:30807
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_fc44fba1_e566_4e40_accc_c46cfc0b579e
is encoded by: hsa:2678
has only substance units: false
boundary condition: true
name: GGT1
is: P19440
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_c819ea1b_1ed2_4599_b0b9_b3146914cd3d
type: Species
is: SBO:0000252
name: _AI480132_1_c
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI480132
boundary condition: true

metaM xol7aone c
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: HMDB01993
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: CHEBI:17899
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: 7alpha-hydroxycholest-4-en-3-one

metaM xoltriol c
type: Species
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB01457
is: CHEBI:16496
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110055#_afb01554_69b0_482d_80bb_51c0ba1abd1e
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q9NY28
is encoded by: hsa:26290
boundary condition: true
name: GALNT8
initial amount: NaN
has only substance units: false

metaM gpi sig r
is: CHEBI:58190
is: SBO:0000247
initial concentration: 1.0
is: HMDB00224
notes: FORMULA: Y CHARGE: 0
initial amount: NaN
constant: false
boundary condition: false
type: Species
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
has only substance units: false

metaR ETOHt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD
reversible: true
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000000
name: ethanol reversible transport
fast: false
product: MODEL1310110055#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_metaR_ACGALFUCGALACGALFUCGALACGLCGAL14ACGLCGALGLUSIDEtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
product: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000000
reversible: true
name: blood group intracellular transport
reactant: MODEL1310110055#
is: SBO:0000185
type: Reaction
fast: false

metaR PHCHGSm
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
reactant: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#
reversible: true
fast: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial

metaR S6T14g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000176
product: MODEL1310110055#
fast: false
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
is described by: ECO:0000000

metaR r1608
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110055#
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110055#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110055#

metaR NADH2 u10m
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
fast: false
is version of: http://identifiers.org/ec-code/1.6.5.3
modifier: MODEL1310110055#
name: NADH dehydrogenase, mitochondrial
is described by: ECO:0000134
reactant: MODEL1310110055#
type: Reaction
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.6.99.3
reversible: false
kinetic law: MODEL1310110055#

metaM HC02205 e
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:28099
name: prostaglandin-b2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_addd9a69_0a72_4916_8eb9_0d15542392f4
is: SBO:0000252
constant: false
is: Q16739
is encoded by: hsa:7357
type: Species
name: UGCG
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR 34DHPLACOX
notes: GENE_ASSOCIATION: (218.1) or (222.1) or (220.1) or (221.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
kinetic law: MODEL1310110055#
is: SBO:0000176
reactant: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
name: 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase
reversible: false
fast: false
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_32fe0a16_2cae_4a14_add4_e300d907242e
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q99643
boundary condition: true
has only substance units: false
name: SDHC
constant: false
type: Species
is encoded by: hsa:6391

metaM sT antigen g
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C25H40N2O18X CHARGE: -1
initial concentration: 1.0
name: sialyl-T antigen
type: Species
is: CHEBI:16565
has only substance units: false

metaR CHAT
is version of: http://identifiers.org/ec-code/2.3.1.6
fast: false
kinetic law: MODEL1310110055#
name: Choline O-acetyltransferase
is: SBO:0000176
type: Reaction
product: MODEL1310110055#
is described by: ECO:0000269
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
modifier: MODEL1310110055#
reversible: true

metaM grdp x
name: geranyl diphosphate(3-)
is: CHEBI:58057
type: Species
is: SBO:0000247
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01285
boundary condition: false
has only substance units: false

metaR 34DHXMANDACOX NADP
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
type: Reaction
is: SBO:0000176
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is described by: ECO:0000269
fast: false
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110055#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110055#_74d82080_c06e_4862_9cea_db74be54b472
type: Species
is encoded by: hsa:8818
is: O94777
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: DPM2
constant: false

metaM HC01842 c
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
initial amount: NaN
name: Phosphodimethylethanolamine
type: Species
is: CHEBI:31997

http://identifiers.org/biomodels.db/MODEL1310110055#_9a13a0af_a4a7_48a9_b5ff_7bab8184f869
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is: O95167
name: NDUFA3
initial concentration: NaN
is encoded by: hsa:4696
initial amount: NaN
type: Species

metaM ttdca e
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
is: CHEBI:30807
boundary condition: false
constant: false
initial amount: NaN
is: C06424
is: SBO:0000247
name: tetradecanoate (n-C14:0)
has only substance units: false
is: HMDB00806
type: Species
initial concentration: 1.0

metaR S6TASE9ly
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110055#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.4
name: N-acetylgalactosamine-6-sulfatase, lysosomal
modifier: MODEL1310110055#
type: Reaction
fast: false
kinetic law: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110055#

metaM chsterol m
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
boundary condition: false
initial amount: NaN
name: cholesterol
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00067
initial concentration: 1.0
is: CHEBI:16113
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_adb1e575_28f5_4700_8fbe_88e7e622f9e4
name: HMGCR
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3156
constant: false
has only substance units: false
is: P04035

metaR FAOXC140
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
is: SBO:0000176
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reactant: MODEL1310110055#
fast: false
reversible: false
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110055#
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110055#_dd4ef580_cbfa_4a20_b775_c2dd36d53894
is encoded by: hsa:248
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is: P09923
initial amount: NaN
name: ALPI
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_metaR_ACGALFUCGALACGALFUCGALACGLCGAL14ACGLCGALGLUSIDEte
kinetic law: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
reversible: true
name: blood group intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110055#
is: SBO:0000185
type: Reaction
fast: false

metaM HC02205 c
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
name: prostaglandin-b2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
initial concentration: 1.0
is: CHEBI:28099

metaM g6p r
initial concentration: 1.0
is: C00092
name: D-Glucose 6-phosphate
is: HMDB01401
is: CHEBI:61548
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
initial amount: NaN
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_341e179b_ddf3_494b_a041_b41747ad4680
is: SBO:0000252
boundary condition: true
has only substance units: false
name: IVD
is encoded by: hsa:3712
is: B3KVI7
type: Species
constant: false
initial amount: NaN
initial concentration: NaN

metaM cmpacna c
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial amount: NaN
is: CHEBI:57812
is: HMDB01176
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
name: CMP-N-acetyl-beta-neuraminate(2-)
initial concentration: 1.0

metaM chsterol l
is: SBO:0000247
constant: false
boundary condition: false
name: cholesterol
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: HMDB00067
type: Species
is: CHEBI:16113
has only substance units: false
initial amount: NaN

metaR r0835
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.5.4.16
modifier: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2

http://identifiers.org/biomodels.db/MODEL1310110055#_de3cd256_57e6_4513_9d95_f19dfdcf9078
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:7371
has only substance units: false
is: Q9BZX2
name: UCK2

metaR ADNCYC
is: SBO:0000176
modifier: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/4.6.1.1
reversible: false
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
kinetic law: MODEL1310110055#
type: Reaction
reactant: MODEL1310110055#
name: adenylate cyclase

metaR r0559
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
product: MODEL1310110055#
is: SBO:0000176
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1

metaR r1823
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
name: Y+LAT2 Utilized transport
product: MODEL1310110055#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110055#_6d1470d6_1425_4ea1_bf8a_095cf8e5c5f4
constant: false
boundary condition: true
name: MAN2A2
is encoded by: hsa:4122
initial amount: NaN
is: Q9P1E4
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_eeef39e5_28b3_4443_9d4b_8637096e5bf5
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:AI697028
has only substance units: false
name: _AI697028_1_e
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_7a4c7751_3eea_4170_9638_8e585bec4052
initial amount: NaN
is encoded by: hsa:3032
name: HADHB
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is: P55084

metaM 2hb e
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
is: CHEBI:1148
constant: false
is: HMDB00008
name: 2-Hydroxybutyrate
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false

metaR D LACt2
modifier: MODEL1310110055#
name: D-lactate transport via proton symport
reactant: MODEL1310110055#
product: MODEL1310110055#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
is: SBO:0000185
kinetic law: MODEL1310110055#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_abbd21f6_6430_4b68_8925_0c817e3c6728
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: PLA2G6
type: Species
is: O60733
is encoded by: hsa:8398
constant: false
has only substance units: false

metaR GALASE12ly
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110055#
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110055#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR O2Stn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110055#
is: SBO:0000185
fast: false
name: superoxide anion transport via diffusion (nucleus)
product: MODEL1310110055#
type: Reaction
reversible: true
reactant: MODEL1310110055#

metaM CE2418 m
has only substance units: false
is: CHEBI:28387
type: Species
boundary condition: false
initial concentration: 1.0
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
initial amount: NaN
is: SBO:0000247
is: HMDB11123
constant: false

metaR r2139
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
modifier: MODEL1310110055#
reactant: MODEL1310110055#
product: MODEL1310110055#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110055#
is described by: ECO:0000000
reversible: true
fast: false

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_ce24cf83_e71b_44f3_8b46_28b311f4e2ea
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2224
constant: false
has only substance units: false
is: P14324
name: FDPS
boundary condition: true
initial amount: NaN
type: Species

metaR EX 3octdeccrn
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyoctadecanoyl carnitine
type: Reaction

metaR r1822
type: Reaction
name: Y+LAT2 Utilized transport
fast: false
is described by: ECO:0000000
modifier: MODEL1310110055#
reversible: false
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR ACHEe
fast: false
kinetic law: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.7
reversible: false
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110055#
name: Acetylcholinesterase
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_49908ddd_b9c9_48ea_bc26_c9bb9cc81965
has only substance units: false
initial concentration: NaN
type: Species
name: PDE4C
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is: Q7KYS4
is encoded by: hsa:5143

http://identifiers.org/biomodels.db/MODEL1310110055#_7664a2f5_6145_4fbc_9885_0161ab282f5e
constant: false
is: SBO:0000252
name: CRAT
is encoded by: hsa:1384
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_7295cbce_521a_44ef_9291_553941f38d78
boundary condition: true
is encoded by: hsa:51181
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is: Q7Z4W1
type: Species
initial concentration: NaN
name: DCXR

metaR DAGt
is: SBO:0000185
type: Reaction
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000269
name: diacylglycerol transport
reversible: true
fast: false
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110055#_2d54c6e9_8232_4989_9cca_899ab9bc500e
is encoded by: hsa:51166
name: AADAT
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is: Q8N5Z0
boundary condition: true
type: Species

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaR r0838
modifier: MODEL1310110055#
name: Free diffusion
reversible: true
reactant: MODEL1310110055#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.4
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
kinetic law: MODEL1310110055#
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_0506753c_a209_4d21_ab29_cc944a71f74d
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:5281
initial amount: NaN
is: Q6IB04
name: PIGF

http://identifiers.org/biomodels.db/MODEL1310110055#_427f1be9_7123_489e_8917_02c44262618a
type: Species
name: PDE8A
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5151
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true

metaR 5MTHFt2le
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
fast: false
product: MODEL1310110055#
reversible: true
name: 5-methyltetrahydrofolate transport via anion exchange
is described by: ECO:0000134
type: Reaction

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaM dolmanp L r
name: Dolichyl phosphate D-mannose, human liver homolog
initial amount: NaN
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: CHEBI:15809

metaM 2hb c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:1148
type: Species
has only substance units: false
is: HMDB00008
name: 2-Hydroxybutyrate
is: SBO:0000247
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
boundary condition: false

metaR PROSTGD2t
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
product: MODEL1310110055#
is: SBO:0000185
reversible: true
reactant: MODEL1310110055#
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
fast: false
kinetic law: MODEL1310110055#
is described by: ECO:0000269
modifier: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_769cbbeb_d7ef_4b1a_aa46_77d16055ed19
has only substance units: false
constant: false
is: Q9NPC4
initial concentration: NaN
name: A4GALT
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:53947

metaR r1824
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
fast: false
reactant: MODEL1310110055#
modifier: MODEL1310110055#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110055#
type: Reaction
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_bfd4319f_291e_4406_b1f5_718374180cdd
is: SBO:0000252
name: CDS2
initial concentration: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:8760
is: O95674

http://identifiers.org/biomodels.db/MODEL1310110055#_6b235260_b019_4f89_ae6c_a533493958f9
constant: false
has only substance units: false
is: P48448
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:222
boundary condition: true
type: Species
name: ALDH3B2
initial amount: NaN

metaM 5fthf e
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
is: SBO:0000247
is: HMDB01562
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:57457
name: 5-formyltetrahydrofolate(2-)

metaR C10DCCACT
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacoyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_0913f33c_a031_42b8_903d_100d377366be
has only substance units: false
is encoded by: hsa:8733
is: O43292
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
name: GPAA1

metaR r0839
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.3.1.70
product: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
name: Postulated transport reaction
fast: false
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
modifier: MODEL1310110055#
reversible: true
is: SBO:0000185
type: Reaction

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR UMPK3n
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
product: MODEL1310110055#
name: UMP kinase (UTP),nuclear
reversible: true

metaR PI45P5Pn
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:NCD
reversible: false
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase, nuclear
type: Reaction
is described by: ECO:0000000
product: MODEL1310110055#
is: SBO:0000176
kinetic law: MODEL1310110055#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110055#_4deab657_2cd2_48bd_8983_92110a5a4db9
is: SBO:0000252
is: A6NFM2
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: PYCR1
is encoded by: hsa:5831
constant: false

metaR O2Stm
is: SBO:0000185
product: MODEL1310110055#
is described by: ECO:0000000
name: superoxide anion transport via diffusion (mitochondria)
reactant: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
kinetic law: MODEL1310110055#
reversible: true
fast: false

metaR CSPG Etly
reactant: MODEL1310110055#
product: MODEL1310110055#
kinetic law: MODEL1310110055#
name: chondroitin sulfate E transport, extracellular to lysosome
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
reversible: false
is described by: ECO:0000000

metaM 34dhoxmand m
type: Species
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB01866
is: CHEBI:27637
constant: false
name: 3,4-Dihydroxymandelate
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_cfe2c483_7c4c_4236_962e_5ac7ee693353
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:54898
name: ELOVL2
is: Q9NXB9
type: Species

metaM Rtotal2 c
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB01564
has only substance units: false
initial amount: NaN
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: CHEBI:57876
name: R total 2 position

metaR CYSGLUexR
is described by: ECO:0000304
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000185
fast: false
modifier: MODEL1310110055#
type: Reaction
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110055#
name: L-cysteine/L-glutamine reversible exchanger

metaM phe L e
is: HMDB00159
constant: false
is: CHEBI:17295
type: Species
is: SBO:0000247
boundary condition: false
name: L-phenylalanine
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR NMNATr
name: nicotinamide-nucleotide adenylyltransferase
kinetic law: MODEL1310110055#
is described by: ECO:0000269
product: MODEL1310110055#
modifier: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.1

http://identifiers.org/biomodels.db/MODEL1310110055#_c3a51db2_974b_4bd3_adcf_3b520d77edea
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10449
is: P42765
name: ACAA2
initial amount: NaN
boundary condition: true

metaR r1600
reactant: MODEL1310110055#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
product: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
fast: false

metaR 2HBO
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.27
kinetic law: MODEL1310110055#
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
is: SBO:0000176
product: MODEL1310110055#
reversible: true
type: Reaction
reactant: MODEL1310110055#

metaR P4507A1r
is version of: http://identifiers.org/ec-code/1.14.13.17
is described by: ECO:0000269
reactant: MODEL1310110055#
type: Reaction
fast: false
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (1581.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.17 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110055#
name: cytochrome P450, family 7, subfamily A, polypeptide 1

metaR SPODM
name: superoxide dismutase
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
modifier: MODEL1310110055#
type: Reaction
is version of: http://identifiers.org/ec-code/1.15.1.1
product: MODEL1310110055#
reversible: false
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000269
is: SBO:0000176
fast: false

metaR ALAGLNexR
fast: false
is: SBO:0000185
name: L-alanine/glutamine reversible exchange
kinetic law: MODEL1310110055#
is described by: ECO:0000304
reactant: MODEL1310110055#
modifier: MODEL1310110055#
type: Reaction
product: MODEL1310110055#
reversible: true
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaR C4STMO1r
is version of: http://identifiers.org/ec-code/1.14.13.72
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
fast: false
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
modifier: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
product: MODEL1310110055#
type: Reaction
kinetic law: MODEL1310110055#

metaM 5mta c
is: SBO:0000247
has only substance units: false
is: C00170
type: Species
name: 5-Methylthioadenosine
is: HMDB01173
initial amount: NaN
is: CHEBI:17509
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
boundary condition: false
constant: false
initial concentration: 1.0

metaR FATP3t
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
fast: false
modifier: MODEL1310110055#
product: MODEL1310110055#
type: Reaction
name: fatty acid electroneutral transport
is: SBO:0000185

metaR PHEATB0tc
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Phenylalanine into the intestinal cells by ATB0 transporter
type: Reaction

metaM lac L c
is: HMDB00190
name: (S)-lactate
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: CHEBI:16651
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_ff447098_5c9c_46dc_aa1a_79b12dd46e82
initial concentration: NaN
constant: false
name: SLC38A3
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:10991
is: Q99624
boundary condition: true
initial amount: NaN

metaR LEUKTRA4t
fast: false
is: SBO:0000185
name: leukotriene A4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reversible: true
type: Reaction

metaR RE2972M
is described by: ECO:0000000
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.1.67
reactant: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
fast: false
name: RE2972
reversible: true
is: SBO:0000176

metaM ctp c
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00082
is: C00063
name: CTP
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
type: Species
has only substance units: false
is: CHEBI:37563
boundary condition: false

metaR GLCAASE8ly
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.31
name: beta-glucuronidase, lysosomal
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
modifier: MODEL1310110055#
type: Reaction
reversible: false
reactant: MODEL1310110055#

metaM Rtotal2 e
name: R total 2 position
initial concentration: 1.0
has only substance units: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
initial amount: NaN
is: HMDB00244
is: SBO:0000247
type: Species
is: CHEBI:3554
is: C00255
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_e3c3fe2b_a549_4958_b128_635fdc689307
name: AK5
is: SBO:0000252
is encoded by: hsa:26289
boundary condition: true
has only substance units: false
type: Species
constant: false
is: Q9Y6K8
initial amount: NaN
initial concentration: NaN

metaM ksi pre11 g
type: Species
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 11
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:28067

http://identifiers.org/biomodels.db/MODEL1310110055#_75febf0c_200e_4dd3_b6f1_4b91edbfd5a4
has only substance units: false
is encoded by: hsa:956
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: O75355
name: ENTPD3
is: SBO:0000252
type: Species

metaM coa m
name: Coenzyme A
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB01423
initial concentration: 1.0
is: CHEBI:57287
type: Species
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: SBO:0000247
is: C00010

metaR r1828
is described by: ECO:0000000
kinetic law: MODEL1310110055#
product: MODEL1310110055#
modifier: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction
fast: false

metaR r1602
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110055#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110055#
reversible: true
product: MODEL1310110055#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110055#_b8aab10b_d306_46d7_814a_5893bf1282d6
initial concentration: NaN
is: SBO:0000252
constant: false
is: O15382
is encoded by: hsa:587
has only substance units: false
type: Species
initial amount: NaN
name: BCAT2
boundary condition: true

metaM vacccrn c
is: HMDB06351
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
name: Vaccenyl carnitine
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110055#_487bd96f_8a6b_4e3a_b759_2d111bed5f68
initial amount: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:2517
is: SBO:0000252
boundary condition: true
is: P04066
initial concentration: NaN
name: FUCA1

metaR ETF
product: MODEL1310110055#
modifier: MODEL1310110055#
reactant: MODEL1310110055#
type: Reaction
name: electron transfer flavoprotein
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
reversible: false
fast: false
kinetic law: MODEL1310110055#

metaR LEUtec
name: L-leucine transport via diffusion (extracellular to cytosol)
is: SBO:0000185
kinetic law: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110055#
reversible: true
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB

metaR 3MOX4HOXPGALDOX
kinetic law: MODEL1310110055#
is: SBO:0000176
fast: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
type: Reaction
product: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110055#
modifier: MODEL1310110055#
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase
reversible: false

metaM ala L m
type: Species
is: HMDB00161
boundary condition: false
initial amount: NaN
is: CHEBI:16977
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial concentration: 1.0
name: L-alanine

metaM 5mta e
initial concentration: 1.0
notes: FORMULA: C11H15N5O3S CHARGE: 0
is: SBO:0000247
is: C00170
has only substance units: false
initial amount: NaN
type: Species
is: HMDB01173
is: CHEBI:17509
name: 5-Methylthioadenosine
constant: false
boundary condition: false

metaM udpglcur c
boundary condition: false
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
type: Species
is: CHEBI:58052
name: UDP-D-glucuronate
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
is: C00167
is: HMDB00935

metaR r1829
is described by: ECO:0000000
is: SBO:0000185
reversible: false
fast: false
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110055#
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110055#
reactant: MODEL1310110055#

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR r1603
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110055#
fast: false
reactant: MODEL1310110055#
product: MODEL1310110055#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000

metaR FAOXC1811602m
fast: false
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
product: MODEL1310110055#
is: SBO:0000176
modifier: MODEL1310110055#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110055#
reversible: false
is described by: ECO:0000000
name: Beta oxidation fatty acid

http://identifiers.org/biomodels.db/MODEL1310110055#_metaM_galacglcgalacglcgal14acglcgalgluside_hs_g
type: Species
is: CHEBI:26174
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0
name: I-antigen
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM pan4p m
constant: false
name: pantetheine 4'-phosphate(2-)
has only substance units: false
type: Species
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial amount: NaN
is: CHEBI:47942
is: HMDB01416
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM ksii core4 pre7 g
is: SBO:0000247
is: C00130
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C75H121N6O56SX CHARGE: -2
has only substance units: false
initial amount: NaN
is: HMDB00175
constant: false
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 7
type: Species

metaM s2l2n2m2masn e
type: Species
name: de-Fuc form of PA6
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C84H135N6O61X CHARGE: -2
is: HMDB00244
boundary condition: false
is: C00255
is: SBO:0000247
constant: false
is: CHEBI:3554

metaM ksi pre26 g
is: SBO:0000247
has only substance units: false
is: CHEBI:28067
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 26
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species

metaM acmana r
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01129
name: N-acetyl-D-mannosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
constant: false
is: CHEBI:17122
initial amount: NaN
has only substance units: false

metaR r2358
is: SBO:0000185
product: MODEL1310110055#
reactant: MODEL1310110055#
reversible: true
kinetic law: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport

metaR URIt
reversible: true
name: uridine facilated transport in cytosol
reactant: MODEL1310110055#
type: Reaction
modifier: MODEL1310110055#
is described by: ECO:0000269
product: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is: SBO:0000185
kinetic law: MODEL1310110055#

metaR UDPG4E
modifier: MODEL1310110055#
product: MODEL1310110055#
is described by: ECO:0000134
kinetic law: MODEL1310110055#
is version of: http://identifiers.org/ec-code/5.1.3.2
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
reversible: true
name: UDPglucose 4-epimerase
reactant: MODEL1310110055#
fast: false

metaM 3hdeccoa m
constant: false
name: 3-hydroxyhexadecenoylcoa
type: Species
has only substance units: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB02288

metaR r1604
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110055#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110055#
reversible: true
product: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_8cfbc570_ac81_435d_9079_ac8efcb55f54
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:112
name: ADCY6
initial amount: NaN
initial concentration: NaN
constant: false

metaM ala L e
initial amount: NaN
constant: false
name: L-alanine
type: Species
is: HMDB00161
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16977
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110055#_3c481f79_fb8d_4add_b8e6_54d2cef21391
has only substance units: false
is encoded by: hsa:55350
type: Species
has part: O95498
name: VNN3:VNN2:VNN1
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:8875
is: SBO:0000297

metaM gthox c
initial amount: NaN
is: C00127
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
initial concentration: 1.0
type: Species
boundary condition: false
name: Oxidized glutathione
constant: false
is: CHEBI:58297
is: HMDB03337
is: SBO:0000247
has only substance units: false

metaR r2357
kinetic law: MODEL1310110055#
fast: false
reversible: true
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110055#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110055#_43ae3433_1773_46f2_9a58_c9ac70dff67f
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: PISD
is encoded by: hsa:23761
has only substance units: false
initial amount: NaN
is: Q9UG56

metaM dhdascb e
constant: false
boundary condition: false
type: Species
is: HMDB01264
initial amount: NaN
name: dehydroascorbide(1-)
initial concentration: 1.0
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
has only substance units: false
is: SBO:0000247
is: CHEBI:58070

metaR FAOXC163x
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)x
type: Reaction

metaR Htg
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110055#
reactant: MODEL1310110055#
name: proton diffusion (Golgi)
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false

metaR CYTK5n
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
product: MODEL1310110055#
name: cytidylate kinase (CMP),nuclear
modifier: MODEL1310110055#
fast: false
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110055#

metaR EX 5fthf LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-Formyltetrahydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110055#_3ea12598_cdbe_49fb_8bdc_1be040bd0556
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10317
constant: false
initial concentration: NaN
name: B3GALT5

metaR UMPKn
type: Reaction
reversible: true
modifier: MODEL1310110055#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
name: UMP kinase, nuclear
product: MODEL1310110055#
fast: false

metaR r1605
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110055#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR r0434
is: SBO:0000176
type: Reaction
reversible: true
kinetic law: MODEL1310110055#
fast: false
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
product: MODEL1310110055#
reactant: MODEL1310110055#
modifier: MODEL1310110055#
is described by: ECO:0000000

metaM coa n
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: coenzyme A(4-)
type: Species
has only substance units: false
constant: false
is: CHEBI:57287
is: HMDB01423
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010

metaM em2emgacpail hs r
boundary condition: false
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
is: HMDB03125
type: Species
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16240
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110055#_6d0da118_ff97_4d98_aeb2_60b0af16f278
name: SDR16C5
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: B3KT84
type: Species
is encoded by: hsa:195814
initial amount: NaN
is: SBO:0000252

metaM phe L c
is: HMDB00159
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:17295
name: L-phenylalanine
type: Species
initial concentration: 1.0
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
has only substance units: false

metaR TYRt
modifier: MODEL1310110055#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110055#
product: MODEL1310110055#
reactant: MODEL1310110055#
name: L-tyrosine transport
fast: false
reversible: true
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
is: SBO:0000185

metaM ksi pre13 g
constant: false
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
is: C00130
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 13
has only substance units: false
boundary condition: false
is: HMDB00175
initial amount: NaN
type: Species
is: CHEBI:58053
initial concentration: 1.0

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR M8MASNterg
kinetic law: MODEL1310110055#
is: SBO:0000185
name: m8masn transport from ER to Golgi apparatus
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110055#
product: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11007802 NOTES:NCD
reversible: false

metaR r0437
product: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
reactant: MODEL1310110055#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
type: Reaction
modifier: MODEL1310110055#
is version of: http://identifiers.org/ec-code/4.1.2.13
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110055#_8c5a7f11_af77_471c_a039_afda96017dc2
name: SLC5A2
has only substance units: false
constant: false
is encoded by: hsa:6524
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
is: P31639

http://identifiers.org/biomodels.db/MODEL1310110055#_81b0586d_f454_4d5b_8067_c6abdce792c6
initial amount: NaN
constant: false
name: B4GALT3
boundary condition: true
has only substance units: false
is encoded by: hsa:8703
type: Species
is: A8K5Z0
initial concentration: NaN
is: SBO:0000252

metaR r1606
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110055#
is described by: ECO:0000000
reactant: MODEL1310110055#
product: MODEL1310110055#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR S6T13g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
is: SBO:0000176
kinetic law: MODEL1310110055#
product: MODEL1310110055#
modifier: MODEL1310110055#
reversible: false
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110055#

http://identifiers.org/biomodels.db/MODEL1310110055#_a4c2fe6d_7fa9_4f8a_8df1_ded848a07d9c
boundary condition: true
constant: false
is encoded by: hsa:D29675
is: SBO:0000252
initial amount: NaN
name: _D29675_1_e
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_8f34d036_779e_41b5_9bc5_c2a73f28e426
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: ACSL4
is encoded by: hsa:2182
initial concentration: NaN
is: Q5JWV8

metaR CHSTEROLtrc
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
type: Reaction
reversible: true
product: MODEL1310110055#
is: SBO:0000185
name: transport of cholesterol into the cytosol
fast: false
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#

metaM dhdascb c
has only substance units: false
is: CHEBI:58070
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
initial concentration: 1.0
type: Species
constant: false
name: dehydroascorbide(1-)
is: HMDB01264

metaR FUM
product: MODEL1310110055#
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110055#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.2
is: SBO:0000176
fast: false
reversible: true
name: fumarase
reactant: MODEL1310110055#
modifier: MODEL1310110055#

metaM CE5125 x
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5125
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:12947
boundary condition: false
name: (2S)-pristanoyl-CoA
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110055#_b4b2248f_e149_4c60_9a94_32d935417e29
is: Q9UHW9
boundary condition: true
is: SBO:0000252
is encoded by: hsa:9990
constant: false
initial concentration: NaN
name: SLC12A6
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110055#_a6308df3_392f_46bf_b7be_3eb9f45028b5
type: Species
initial amount: NaN
is: E9PRW7
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:25841
boundary condition: true
name: ABTB2
initial concentration: NaN

metaR r2359
fast: false
kinetic law: MODEL1310110055#
reversible: true
is: SBO:0000185
reactant: MODEL1310110055#
name: Organic anion transporter 5 Utilized transport
type: Reaction
product: MODEL1310110055#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM ctp e
is: HMDB00082
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial concentration: 1.0
is: CHEBI:37563
name: CTP(4-)
has only substance units: false
constant: false
initial amount: NaN

metaR RE3301C
is version of: http://identifiers.org/ec-code/3.1.4.4
type: Reaction
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
is: SBO:0000176
reactant: MODEL1310110055#
fast: false
reversible: true
product: MODEL1310110055#
name: RE3301
is described by: ECO:0000000
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#

metaR ASNtN1
is described by: ECO:0000269
type: Reaction
name: Asparagine transport (Na, H coupled)
reversible: true
reactant: MODEL1310110055#
modifier: MODEL1310110055#
kinetic law: MODEL1310110055#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110055#

metaR r0830
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
product: MODEL1310110055#
fast: false
kinetic law: MODEL1310110055#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110055#
reactant: MODEL1310110055#
is: SBO:0000185

metaR CHOLPtg
reversible: true
kinetic law: MODEL1310110055#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ
is described by: ECO:0000000
name: choline phosphate intracellular transport
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110055#
product: MODEL1310110055#

metaR OCTAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
reactant: MODEL1310110055#
kinetic law: MODEL1310110055#
name: Octanoate transport via diffusion
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110055#
is described by: ECO:0000000
reversible: true