metaM CE2243 c
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: trans-eicos-2-enoyl-CoA
is: SBO:0000247
boundary condition: false
is: CHEBI:52324
constant: false
notes: FORMULA: C41H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h20-21,28-30,34-36,40,51-52H,4-19,22-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b21-20+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE2243

metaR GLAl
product: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.22
kinetic law: MODEL1310110054#
reversible: false
reactant: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (2717.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.22 Confidence Level: 4 AUTHORS: PMID:11775551,PMID:11828341,PMID:15003450,PMID:2836863 NOTES:NJ
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: galactosidase, alpha

metaR ARACHCRNt
product: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110054#
reversible: false
fast: false
reactant: MODEL1310110054#
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110054#_16a2680a_0295_4fc3_ab6a_e1ba18579c09
name: GGT5
initial concentration: NaN
is encoded by: hsa:2687
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is: P36269
initial amount: NaN

metaM lgt S c
is: CHEBI:57474
name: (R)-S-lactoylglutathionate(1-)
initial amount: NaN
has only substance units: false
is: HMDB01066
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1

metaM 2mop c
name: 2-methyl-3-oxopropanoate
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB01172
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: CHEBI:57700
constant: false

metaR r1651
kinetic law: MODEL1310110054#
is described by: ECO:0000000
product: MODEL1310110054#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110054#
type: Reaction
is: SBO:0000185
reversible: true
modifier: MODEL1310110054#

metaM mmcoa R m
name: (R)-methylmalonyl-CoA(5-)
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB01269
type: Species
is: CHEBI:57326
boundary condition: false
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_3a037ee8_e599_4862_9ca2_040a0ddc22eb
is: SBO:0000252
is: Q308M7
name: ENPP3
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:5169

metaR ICDHyrm
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
type: Reaction
reactant: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110054#
name: Isocitrate dehydrogenase (NADP+)
is described by: ECO:0000269
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_2f1f299c_260b_4bd2_bce5_b968cbfd861d
name: B3GNT5
is encoded by: hsa:84002
is: SBO:0000252
is: Q9BYG0
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
constant: false

metaM ddcacoa m
is: HMDB03571
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
is: C01832
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:57375
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
name: Dodecanoyl-CoA (n-C12:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110054#_47b9c380_f49d_4eea_a3da_40d32256e3ef
has only substance units: false
constant: false
is encoded by: hsa:4967
initial amount: NaN
is: Q02218
boundary condition: true
type: Species
is: SBO:0000252
name: OGDH
initial concentration: NaN

metaM chsterol c
is: CHEBI:16113
initial amount: NaN
constant: false
is: HMDB00067
name: cholesterol
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
type: Species

metaM n2m2mn l
type: Species
is: CHEBI:16680
initial concentration: 1.0
is: HMDB00939
is: SBO:0000247
boundary condition: false
notes: FORMULA: C42H71N3O31 CHARGE: 0
initial amount: NaN
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)
has only substance units: false
constant: false

metaR SGPL12r
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
reactant: MODEL1310110054#
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/4.1.2.27
fast: false
is described by: ECO:0000304
reversible: false
kinetic law: MODEL1310110054#
type: Reaction
name: Sphingosine-1-phosphate lyase
product: MODEL1310110054#
is: SBO:0000176

metaR q10h2tc
product: MODEL1310110054#
is described by: ECO:0000134
fast: false
reversible: true
name: transport of ubiquinol into cytosol
is: SBO:0000185
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110054#

metaM hestratriol e
is: HMDB05896
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: 4,17 dihydroxy estradiol
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
initial concentration: 1.0
type: Species
constant: false

metaR CYTK1m
name: cytidylate kinase (CMP),mitochondrial
reversible: true
is: SBO:0000176
fast: false
product: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
kinetic law: MODEL1310110054#
is described by: ECO:0000134
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_0dc81d11_2385_4773_bcea_8501ccdd90c9
boundary condition: true
is: Q86V21
name: AACS
constant: false
is encoded by: hsa:65985
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252

metaR G14T13g
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
modifier: MODEL1310110054#
is described by: ECO:0000000
product: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false

metaR r1650
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110054#
is described by: ECO:0000000
reactant: MODEL1310110054#
is: SBO:0000185
kinetic law: MODEL1310110054#
product: MODEL1310110054#
type: Reaction

metaR H3MTer U
name: H3 mannosyltransferase, endoplasmic reticulum
modifier: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110054#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110054#_f96c3dba_ee29_4068_a77b_1ba4bae8f8e2
constant: false
name: HK1
boundary condition: true
initial concentration: NaN
has only substance units: false
is: P19367
type: Species
initial amount: NaN
is encoded by: hsa:3098
is: SBO:0000252

metaR PNTEH
type: Reaction
is: SBO:0000176
name: Hydrolase Class ( RXN R02973)
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.1.92
reversible: false
reactant: MODEL1310110054#
product: MODEL1310110054#
fast: false

metaM glyclt c
name: glycolate
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
boundary condition: false
is: HMDB00115
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:29805

http://identifiers.org/biomodels.db/MODEL1310110054#_f3f08202_4bb8_4b88_9b02_8f2ad55be1d8
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is: Q11201
is encoded by: hsa:6482
name: ST3GAL1
has only substance units: false
boundary condition: true

metaR AG13T2g
is: SBO:0000176
reversible: false
product: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110054#
reactant: MODEL1310110054#

metaR ABTti
is described by: ECO:0000000
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000185
type: Reaction
name: L-arabinitol transport via passive diffusion
reversible: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
fast: false

metaR NMNATn
name: nicotinamide-nucleotide adenylyltransferase
type: Reaction
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.1
modifier: MODEL1310110054#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (64802.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.7.1 Confidence Level: 4 AUTHORS: PMID:11027696,PMID:11248244,PMID:12574164 NOTES:IT
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#
fast: false

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_78f2dd2d_c7b1_4fdb_9fde_b005e3d1a561
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:AI091231
type: Species
name: _AI091231_1_c

metaR ASNGLNNaEx
kinetic law: MODEL1310110054#
fast: false
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

http://identifiers.org/biomodels.db/MODEL1310110054#_62af4dda_743a_4154_afcb_72344eb398bc
is: P15531
initial concentration: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
name: NME1
is encoded by: hsa:4830
is: SBO:0000252
initial amount: NaN

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaR NACHEX8ly
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110054#
type: Reaction
reversible: false
reactant: MODEL1310110054#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110054#
kinetic law: MODEL1310110054#

metaR OAADC
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: oxaloacetate decarboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_1c02cb54_9b4a_4fda_bc70_fa2d26869ff6
name: CA9
is: Q16790
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:768
constant: false
boundary condition: true

metaR r1653
reversible: true
type: Reaction
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110054#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110054#
fast: false

metaM ksi pre31 g
boundary condition: false
is: CHEBI:58053
initial concentration: 1.0
initial amount: NaN
is: C00130
type: Species
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
name: keratan sulfate I biosynthesis, precursor 31
has only substance units: false
is: HMDB00175
constant: false
is: SBO:0000247

metaR H2Otg
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
fast: false
name: H2O transport, Golgi apparatus
type: Reaction
product: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000000

metaR S6T13g
type: Reaction
modifier: MODEL1310110054#
reactant: MODEL1310110054#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaM hestratriol c
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
is: HMDB05896
is: SBO:0000247
name: 4,17 dihydroxy estradiol
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR M4MPDOL Lter
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110054#
fast: false
product: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000185
name: m4mpdol flippase
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110054#_b03ac8a4_9ca0_4c79_b1c6_3ba25581f819
is encoded by: hsa:83884
initial amount: NaN
constant: false
is: Q9BXI2
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: SLC25A2
type: Species

metaR r2537
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
reversible: true
fast: false
product: MODEL1310110054#
is: SBO:0000185
kinetic law: MODEL1310110054#
is described by: ECO:0000000
reactant: MODEL1310110054#
name: Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110054#_14530e34_ac9a_48d7_a30a_9f98fb1ebb39
is: SBO:0000252
has only substance units: false
is: B2RB13
boundary condition: true
constant: false
is encoded by: hsa:23305
initial concentration: NaN
initial amount: NaN
name: ACSL6
type: Species

metaM CE2422 m
has only substance units: false
is: CHEBI:28387
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
is: HMDB11123

metaM dgsn m
name: Deoxyguanosine
boundary condition: false
is: HMDB00085
initial concentration: 1.0
is: C00330
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:17172

http://identifiers.org/biomodels.db/MODEL1310110054#_068dfcae_a8ba_47b8_86c8_418245eea430
is: P09417
initial amount: NaN
is encoded by: hsa:5860
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
name: QDPR

http://identifiers.org/biomodels.db/MODEL1310110054#_a3875495_223f_4341_91d6_9bcfae610663
type: Species
has only substance units: false
name: ST3GAL3
boundary condition: true
is encoded by: hsa:6487
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR NACHEX14ly
kinetic law: MODEL1310110054#
is: SBO:0000176
fast: false
modifier: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110054#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
type: Reaction
reversible: false

metaR r1652
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110054#
fast: false
modifier: MODEL1310110054#

metaM 5aizc c
initial concentration: 1.0
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
has only substance units: false
constant: false
is: HMDB06273
is: SBO:0000247
is: CHEBI:58564
boundary condition: false
initial amount: NaN
is: C04751
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
type: Species

metaR ACOAD10m
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
is: SBO:0000176
reactant: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
reversible: false
product: MODEL1310110054#
is described by: ECO:0000269
modifier: MODEL1310110054#

metaR ACHtn
kinetic law: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
is described by: ECO:0000000
name: Acetylcholin transport, nuclear trhough pores
reactant: MODEL1310110054#
type: Reaction
reversible: true
is: SBO:0000185
fast: false

metaR CYTK1n
type: Reaction
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110054#
is described by: ECO:0000269
reversible: true
name: cytidylate kinase (CMP),nuclear
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is: SBO:0000176
product: MODEL1310110054#

metaR NACHEX25ly
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
modifier: MODEL1310110054#
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110054#

metaR r2538
product: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
kinetic law: MODEL1310110054#
is described by: ECO:0000000
name: Utilized transport
fast: false
is: SBO:0000185

metaR BDMT U
reversible: false
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.142

http://identifiers.org/biomodels.db/MODEL1310110054#_a361a5e3_104e_4c61_a15d_f044631d7d00
is: O60312
initial amount: NaN
constant: false
is encoded by: hsa:57194
name: ATP10A
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_48f39197_e138_4f52_9a6c_76747cd5d0ef
boundary condition: true
is: E9PCP2
constant: false
initial concentration: NaN
name: CPT1B
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1375

metaR ACGAMPM
is described by: ECO:0000269
kinetic law: MODEL1310110054#
type: Reaction
reversible: true
name: phosphoacetylglucosamine mutase
reactant: MODEL1310110054#
is: SBO:0000176
product: MODEL1310110054#
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/5.4.2.3
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
fast: false

metaR F6Tg
type: Reaction
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.68
product: MODEL1310110054#
name: glycoprotein 6-alpha-L-fucosyltransferase
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110054#

metaM 5htrp c
name: 5-hydroxy-L-tryptophan
is: HMDB00472
initial amount: NaN
boundary condition: false
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
constant: false
has only substance units: false
is: CHEBI:17780
initial concentration: 1.0
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_afa8e321_17ae_4879_a4e1_8ccff2649411
is encoded by: hsa:8525
initial concentration: NaN
constant: false
has only substance units: false
name: DGKZ
boundary condition: true
type: Species
is: B7Z2M9
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_dde3f886_b4c5_4dce_9e50_6c7b2a42f41e
is encoded by: hsa:2629
initial amount: NaN
type: Species
is: B7Z6S9
boundary condition: true
is: SBO:0000252
has only substance units: false
name: GBA
initial concentration: NaN
constant: false

metaR GLCNACPT L
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (liver)
fast: false
reversible: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.8.15
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_7b478d1d_a31e_4cb3_a663_6f42e88187a8
is: E5KSL5
initial concentration: NaN
is: SBO:0000252
type: Species
name: DGUOK
initial amount: NaN
is encoded by: hsa:1716
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_c894f320_d9c4_4f2d_94ab_21e1022bbd55
has only substance units: false
is encoded by: hsa:5833
is: SBO:0000252
constant: false
is: F5H8B1
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: PCYT2

metaR PROSTGE2t2
type: Reaction
is described by: ECO:0000269
product: MODEL1310110054#
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
reactant: MODEL1310110054#
name: prostaglandin uniport
is: SBO:0000185
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
fast: false
reversible: true

metaR RE1522M
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1522
is: SBO:0000176
product: MODEL1310110054#
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110054#
is described by: ECO:0000000

metaR r0287
type: Reaction
modifier: MODEL1310110054#
is: SBO:0000176
product: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
kinetic law: MODEL1310110054#
is described by: ECO:0000000
reversible: false
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110054#_049a4402_85fe_4dcf_bdfe_70cc6a2f0875
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
name: B3GNT2
is: SBO:0000252
type: Species
is encoded by: hsa:10678
initial amount: NaN

metaR RE2986X
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110054#
name: RE2986
notes: GENE_ASSOCIATION: (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:10970790,PMID:7775433 NOTES:
reversible: true
modifier: MODEL1310110054#
is described by: ECO:0000000
reactant: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176

metaR SIAASE2ly
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: sialidase, lysosomal
fast: false
reactant: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#

metaM gly c
boundary condition: false
notes: FORMULA: C2H5NO2 CHARGE: 0
is: HMDB00123
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:3339
is: C00037
name: Glycine
type: Species
initial amount: NaN

metaR G14T3g
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
fast: false
product: MODEL1310110054#

metaR B3GNT34g
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
modifier: MODEL1310110054#
reversible: false
fast: false
product: MODEL1310110054#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000269

metaR DNDPt37m
reversible: false
type: Reaction
reactant: MODEL1310110054#
is: SBO:0000185
fast: false
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
product: MODEL1310110054#
name: dUTP transport via dTDP antiport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaM HC00822 e
name: Chitobiose
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:28681
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_32045883_07a4_4193_b19f_3792ff2ba76c
is: SBO:0000252
is encoded by: hsa:205
initial amount: NaN
type: Species
boundary condition: true
is: P27144
constant: false
initial concentration: NaN
name: AK4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_0a4a8b80_dd0f_4387_a0c9_78d6e9a33dc2
type: Species
name: ND4
boundary condition: true
is encoded by: hsa:4538
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P03905
initial concentration: NaN

metaR KAS8
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110054#
type: Reaction
fast: false
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000176
name: b-ketoacyl synthetase (palmitate, n-C16:0)
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:

metaM CE5101 m
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:57795
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101

metaM 13dpg c
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
is: http://identifiers.org/pubchem.compound/3535
type: Species
name: 3-Phospho-D-glyceroyl phosphate
is: C00236
is: HMDB01270
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57604
initial amount: NaN
constant: false
is: SBO:0000247

metaM m4mpdol U r
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
boundary condition: false
is: SBO:0000247
is: CHEBI:37633
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

http://identifiers.org/biomodels.db/MODEL1310110054#_83923bae_061e_46cd_8920_1b708bcb11d8
name: NDUFS6
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:4726
is: SBO:0000252
is: Q6IBC4
initial concentration: NaN
initial amount: NaN

metaR r0074
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.1
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110054#
is: SBO:0000176
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
reactant: MODEL1310110054#

metaM dolglcp U r
type: Species
constant: false
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
is: CHEBI:15812
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR HMGCOAtx
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reversible: true
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
reactant: MODEL1310110054#
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport

http://identifiers.org/biomodels.db/MODEL1310110054#_db100919_1385_47fc_afb0_90254dd8af58
constant: false
is encoded by: hsa:NM 001929
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: _NM_001929_1_c
type: Species
initial concentration: NaN
boundary condition: true

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_c770a3f6_b6e7_4ceb_8cb5_9cd642a3ad95
is: Q9Y2B2
is: SBO:0000252
boundary condition: true
name: PIGL
constant: false
has only substance units: false
is encoded by: hsa:9487
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_28cffd58_8a64_4b85_94e1_db8d28ba6e84
is: SBO:0000252
boundary condition: true
name: SLC22A2
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:6582
initial amount: NaN

metaM m3mpdol L c
is: SBO:0000247
is: CHEBI:37632
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C1480H2428N20O370P20 CHARGE: -20
boundary condition: false
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human liver homolog
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_82d3613a_552a_45d4_ae82_6d17b2b20287
boundary condition: true
type: Species
initial concentration: NaN
is: P00492
name: HPRT1
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3251

metaR PRGNLONESULT
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.8.2.14
fast: false
kinetic law: MODEL1310110054#
reversible: false
name: steroid sulfotransferase
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (6822.1) or (6820.2) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:12145317,PMID:9799594 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.8.2.2
type: Reaction
product: MODEL1310110054#
is described by: ECO:0000269
is: SBO:0000176

metaR r2011
kinetic law: MODEL1310110054#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110054#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110054#
reactant: MODEL1310110054#

metaR PItn
reversible: true
product: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110054#
name: phosphate transport, nuclear
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110054#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_436ce907_704a_428a_862d_72ccfb632cf7
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1376
constant: false
name: CPT2
initial concentration: NaN
has only substance units: false
is: P23786
type: Species
initial amount: NaN

metaM g2m8masn r
type: Species
notes: FORMULA: C82H137N2O65X CHARGE: 0
has only substance units: false
boundary condition: false
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
is: C05874

http://identifiers.org/biomodels.db/MODEL1310110054#_04056c04_75cd_48fe_84f1_4d215b8e214c
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaM 3odcoa m
type: Species
constant: false
is: HMDB03939
name: 3-Oxodecanoyl-CoA
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:28528
has only substance units: false

metaR r1148
product: MODEL1310110054#
is described by: ECO:0000000
reactant: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110054#
name: Active transport
is: SBO:0000185
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_d69073bb_e062_4b89_9a1d_48ffe4786574
is: SBO:0000252
is encoded by: hsa:57786
initial amount: NaN
name: RBAK
type: Species
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q9NYW8

metaR RE1254C
reversible: true
name: RE1254
product: MODEL1310110054#
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:

metaR DMNONCRNt
reactant: MODEL1310110054#
product: MODEL1310110054#
name: 4,8 dimethylnonanoyl carnitine transport (mitochondria)
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
reversible: true
is described by: ECO:0000000

metaR UMPK3
name: UMP kinase (UTP)
product: MODEL1310110054#
type: Reaction
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is: SBO:0000176

metaR SIAT9g
is version of: http://identifiers.org/ec-code/2.4.99.9
modifier: MODEL1310110054#
reversible: false
product: MODEL1310110054#
is: SBO:0000176
fast: false
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
type: Reaction
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
kinetic law: MODEL1310110054#
is described by: ECO:0000000
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_71c120c1_218f_47a1_be04_3f50bece8f9f
is: SBO:0000252
boundary condition: true
type: Species
name: ADCY1
initial amount: NaN
is encoded by: hsa:107
has only substance units: false
constant: false
is: Q08828
initial concentration: NaN

metaM gumgchol e
name: guar gum-glycocholate complex
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/97415
boundary condition: false
notes: FORMULA: C2760026H5060043NO2530006 CHARGE: 0
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false

metaM HC01410 m
is: CHEBI:28706
name: (2E)-Hexenoyl-CoA
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
constant: false
has only substance units: false

metaM HC02207 e
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
name: prostaglandin-c2
type: Species
has only substance units: false
is: CHEBI:27555
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR TYRCBOX
reversible: false
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
modifier: MODEL1310110054#
is: SBO:0000176
name: L-Tyrosine carboxy-lyase
product: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.28
fast: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28

metaR N3Tg
fast: false
type: Reaction
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.122
is described by: ECO:0000000
reactant: MODEL1310110054#
reversible: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110054#_69426da5_1319_4972_8112_80ae3fe441a7
boundary condition: true
is encoded by: hsa:157570
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is: Q56NI9
name: ESCO2

metaR UDPGLCter
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110054#
fast: false
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
product: MODEL1310110054#
kinetic law: MODEL1310110054#

metaR r1147
is described by: ECO:0000000
product: MODEL1310110054#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110054#_e64f42f4_57bd_432c_9fd7_3b9724377453
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:3032
name: HADHB
type: Species
is: P55084
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM ksi deg30 l
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: HMDB00143
is: CHEBI:12936
is: SBO:0000247
name: keratan sulfate I, degradation product 30
has only substance units: false

metaM 4nphsf e
is: HMDB06492
initial concentration: 1.0
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
is: CHEBI:35422
constant: false
is: SBO:0000247
name: 4-Nitrophenyl sulfate
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species

metaR MG3er
kinetic law: MODEL1310110054#
is described by: ECO:0000000
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
reversible: false
fast: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
is: SBO:0000176
product: MODEL1310110054#
type: Reaction

metaR PYK
is described by: ECO:0000134
type: Reaction
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reversible: false
product: MODEL1310110054#
reactant: MODEL1310110054#
name: pyruvate kinase
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.1.40
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_458b2c9e_5516_4a7f_82eb_f5f43a22bcc5
is encoded by: hsa:5336
constant: false
initial amount: NaN
type: Species
name: PLCG2
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P16885
is: SBO:0000252

metaR UMPK4
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (GTP)
modifier: MODEL1310110054#
product: MODEL1310110054#
reversible: true
is: SBO:0000176
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110054#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_80175f4d_ed32_46c5_86bb_b09a9a246b41
constant: false
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:26266
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q9UKG4
name: SLC13A4

metaR FUT18g
reactant: MODEL1310110054#
product: MODEL1310110054#
name: Galactoside 2-alpha-L-fucosyltransferase 1
fast: false
reversible: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.1.69
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ

metaM Rtotalcoa c
has only substance units: false
is: CHEBI:16189
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
is: HMDB01448
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: R total Coenzyme A
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_c08bdacd_bae9_449d_bcec_dfca16a00ee9
is: P26572
name: MGAT1
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:4245
initial concentration: NaN
constant: false
is: SBO:0000252

metaR FAOXC164C143x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)x
type: Reaction

metaR S6T7g
reactant: MODEL1310110054#
is described by: ECO:0000000
reversible: false
product: MODEL1310110054#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110054#
is: SBO:0000176
fast: false
modifier: MODEL1310110054#

metaM CE5853 e
initial concentration: 1.0
constant: false
has only substance units: false
name: alpha-CEHC-glucuronide
boundary condition: false
is: CHEBI:57923
initial amount: NaN
notes: FORMULA: C22H29O10 CHARGE: -1 INCHI: InChI=1/C22H30O10/c1-9-10(2)18-12(11(3)14(9)24)5-7-22(4,32-18)8-6-13(23)30-21-17(27)15(25)16(26)19(31-21)20(28)29/h15-17,19,21,24-27H,5-8H2,1-4H3,(H,28,29)/p-1/t15-,16+,17-,19-,21+,22?/m1/s1 EHMN_ABBREVIATION: CE5853
is: SBO:0000247
type: Species

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaM 2mop m
initial concentration: 1.0
is: CHEBI:57700
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
constant: false
name: 2-methyl-3-oxopropanoate
is: HMDB01172
boundary condition: false

metaR DOLGLCP Lter
reversible: false
kinetic law: MODEL1310110054#
is: SBO:0000185
fast: false
type: Reaction
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110054#
is described by: ECO:0000000

metaM s2l2n2m2masn l
type: Species
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00174
is: CHEBI:18287
name: de-Fuc form of PA6
initial concentration: 1.0
notes: FORMULA: C84H135N6O61X CHARGE: -2
initial amount: NaN

metaM ddcacoa x
type: Species
is: CHEBI:57375
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: SBO:0000247
has only substance units: false
name: Dodecanoyl-CoA (n-C12:0CoA)
is: HMDB03571
is: C01832
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false

metaR GALASE13ly
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110054#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
fast: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_38873d2e_cb1a_432a_a0df_663fe21d080a
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2629
boundary condition: true
name: GBA
is: SBO:0000252
constant: false
initial amount: NaN
type: Species

metaR RE1533M
kinetic law: MODEL1310110054#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
is: SBO:0000176
name: RE1533
is described by: ECO:0000000
product: MODEL1310110054#
modifier: MODEL1310110054#
reactant: MODEL1310110054#

metaR S6TASE10ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110054#
name: galactose-6-sulfate sulfatase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: true
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110054#

metaR ACNAMtn
reactant: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110054#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110054#
type: Reaction
name: N-acetylneuraminate nuclear import
reversible: false

metaR HMGCOAtm
reversible: true
kinetic law: MODEL1310110054#
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
reactant: MODEL1310110054#
product: MODEL1310110054#
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD

metaM ksii core2 pre5 g
notes: FORMULA: C61H99N5O43X CHARGE: -1
initial amount: NaN
is: SBO:0000247
is: HMDB00175
boundary condition: false
is: CHEBI:58053
type: Species
initial concentration: 1.0
is: C00130
has only substance units: false
constant: false
name: keratan sulfate II biosynthesis, precursor 5

metaM lthstrl r
name: 5alpha-cholest-7-en-3beta-ol
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
is: CHEBI:17168
boundary condition: false
initial concentration: 1.0
is: HMDB01170

metaR RE2658R
is: SBO:0000176
type: Reaction
product: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
name: RE2658
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reversible: true
is described by: ECO:0000000

metaR DMHPTCRNCPT2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:made reversible since Keq ~ 0.6. dmhptcoa is a special case because its biochemical fate has not be elucidated. NJ
kinetic law: MODEL1310110054#
type: Reaction
name: 2,6 dimethylheptanoly CoA carnitine transferase
is: SBO:0000176
fast: false
reactant: MODEL1310110054#
product: MODEL1310110054#
reversible: true

metaM HC02207 c
initial amount: NaN
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin-c2
is: CHEBI:27555
type: Species
has only substance units: false
boundary condition: false

metaR RE3242R
reactant: MODEL1310110054#
is: SBO:0000176
modifier: MODEL1310110054#
name: RE3242
reversible: true
fast: false
type: Reaction
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110054#

metaR AG13T13g
kinetic law: MODEL1310110054#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
modifier: MODEL1310110054#
type: Reaction
is: SBO:0000176
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_6fb14528_f53f_4b9f_988c_4f768090628a
has only substance units: false
is encoded by: hsa:6820
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: SULT2B1
constant: false
type: Species
boundary condition: true

metaM 4nphsf c
type: Species
is: HMDB06492
initial amount: NaN
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
initial concentration: 1.0
is: CHEBI:35422
name: 4-Nitrophenyl sulfate
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false

metaM ascb L e
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:38290
is: HMDB00044
type: Species
has only substance units: false
constant: false
name: L-ascorbate
initial amount: NaN

metaR UMPK2
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110054#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110054#
name: UMP kinase (CTP)
kinetic law: MODEL1310110054#
is: SBO:0000176
product: MODEL1310110054#

metaR r2120
product: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110054#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110054#

metaR FAOXC201C181x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_96e7bd7f_5998_4e9b_9d48_957f9bee5349
is encoded by: hsa:8879
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is: O95470
initial amount: NaN
name: SGPL1
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_506c426c_149b_4eed_847a_6d85f037a92a
has only substance units: false
type: Species
name: ALDH7A1
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is: E7EPT3
is encoded by: hsa:501

metaM glyc3p x
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00126
constant: false
is: C00093
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
name: Glycerol 3-phosphate
boundary condition: false
is: CHEBI:57597
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_90654619_6a62_4587_8c5f_2a5f73458f86
name: IK
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:3550
initial concentration: NaN
is: Q13123

metaM cholcoaone x
type: Species
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
is: HMDB06891
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:58507
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
has only substance units: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_4abda4bd_1a39_4f8a_9de3_0eb34244615d
constant: false
initial amount: NaN
is: Q8TD30
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: GPT2
is encoded by: hsa:84706
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_43e64240_db6a_4d12_b2f3_3742515c818e
type: Species
name: CEPT1
is: B3KN25
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10390
has only substance units: false
boundary condition: true

metaR OMHPALTD
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_274f1d32_b555_4125_bf47_48abebc6c0b8
name: IDI2
initial concentration: NaN
is encoded by: hsa:91734
is: SBO:0000252
constant: false
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q9BXS1

http://identifiers.org/biomodels.db/MODEL1310110054#_b56c5795_af84_4e75_bc0e_9f5c99d185ad
is: SBO:0000252
constant: false
initial concentration: NaN
name: _HG2846_HT2983_1_m
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:HG2846-HT2983

http://identifiers.org/biomodels.db/MODEL1310110054#_22c6f121_1f96_4083_b8e0_101d9baf47a6
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6560
type: Species
initial amount: NaN
is: F5H066
initial concentration: NaN
constant: false
name: SLC12A4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_8f45212e_1ad7_4606_a58b_2f6defee4df7
is encoded by: hsa:27034
is: Q6ZWP6
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: ACAD8
initial concentration: NaN
constant: false
has only substance units: false
type: Species

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_7d68a71d_88a6_4617_9515_04c0e28b44c8
name: PANK2
has only substance units: false
constant: false
type: Species
is encoded by: hsa:80025
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR BDHm
kinetic law: MODEL1310110054#
reversible: true
is: SBO:0000176
product: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
is described by: ECO:0000269
reactant: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.1.1.30

http://identifiers.org/biomodels.db/MODEL1310110054#_fe668b3f_ad6b_4825_ae52_1a3889793109
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:D29675
name: _D29675_1_e
is: SBO:0000252

metaM ump n
is: CHEBI:57865
constant: false
is: SBO:0000247
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
name: UMP(2-)
initial amount: NaN
is: HMDB00288
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM pnto R e
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: SBO:0000247
is: HMDB00210
initial concentration: 1.0
is: CHEBI:7916
constant: false
boundary condition: false
name: (R)-Pantothenate

metaR S6TASE21ly
reactant: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
product: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110054#
reversible: true

metaM guln r
constant: false
is: SBO:0000247
has only substance units: false
name: L-gulonate
is: HMDB03290
type: Species
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:13115

metaM dgdp c
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
type: Species
constant: false
is: C00361
has only substance units: false
name: dGDP
is: CHEBI:58595
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00960
initial amount: NaN

metaR O2ter
name: O2 transport, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#
is described by: ECO:0000000
reactant: MODEL1310110054#
type: Reaction
is: SBO:0000185
fast: false

metaR PTE4x
fast: false
is: SBO:0000176
type: Reaction
name: peroxisomal acyl-CoA thioesterase
reversible: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.2.2
modifier: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_08ec085c_ce5e_4b10_be49_5f6a79399555
is: SBO:0000252
name: ACAT2
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: Q9BWD1
constant: false
initial amount: NaN
is encoded by: hsa:39

metaR GLXtp
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110054#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
name: glyoxylate transport, peroxisomal
fast: false

metaM ascb L c
is: SBO:0000247
is: CHEBI:38290
initial amount: NaN
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: HMDB00044
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
name: L-ascorbate
constant: false

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_57faaccd_01a9_4635_a238_c96ea6fdfbb9
is: SBO:0000297
name: DLD:DLST:OGDH:PDHX
has part: P36957
boundary condition: true
has part: Q02218
is encoded by: hsa:1738
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1743
has part: P09622
has part: O00330
is encoded by: hsa:8050
constant: false
has only substance units: false
type: Species
is encoded by: hsa:4967

http://identifiers.org/biomodels.db/MODEL1310110054#_3e8b4341_5203_4b9f_9f66_b47021c3d668
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
name: COX7B
is encoded by: hsa:1349
initial amount: NaN
boundary condition: true
has only substance units: false
is: P24311

http://identifiers.org/biomodels.db/MODEL1310110054#_351cd0fe_7823_4ea4_92d4_8ba500bca719
initial amount: NaN
constant: false
name: PC
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5091
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_30253de0_0f5c_4e23_b3c6_78e24cf84594
is encoded by: hsa:36
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P45954
initial amount: NaN
type: Species
boundary condition: true
name: ACADSB
constant: false

metaR LDH L
modifier: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
name: L-lactate dehydrogenase
fast: false
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
is version of: http://identifiers.org/ec-code/1.1.1.27
is described by: ECO:0000000
kinetic law: MODEL1310110054#

metaR IDOAASE1ly
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
modifier: MODEL1310110054#
fast: false
is: SBO:0000176
name: alpha-L-iduronidase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.76
product: MODEL1310110054#
reactant: MODEL1310110054#
reversible: false
type: Reaction
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_15451456_f146_4299_90d0_3a1b5f109214
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:175
name: AGA
is: SBO:0000252
type: Species
is: P20933
has only substance units: false
initial concentration: NaN

metaM adn c
name: Adenosine
is: HMDB00050
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:16335
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: SBO:0000247
is: C00212
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_7a170b48_2018_4698_88e3_cd7a46105047
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:7841
name: MOGS
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: F5H6D0

metaR PItg
kinetic law: MODEL1310110054#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110054#
name: phosphate transport, Golgi apparatus
type: Reaction
product: MODEL1310110054#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR UMPK5
is: SBO:0000176
product: MODEL1310110054#
is described by: ECO:0000269
type: Reaction
name: UMP kinase (dATP)
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true

metaM ump r
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:57865
constant: false
name: UMP
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00288

http://identifiers.org/biomodels.db/MODEL1310110054#_826fd220_c6aa_445e_b3df_6f90d14683af
has only substance units: false
name: UAP1
initial concentration: NaN
is: Q16222
type: Species
is encoded by: hsa:6675
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN

metaR UMPK7
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
name: UMP kinase (dGTP)
is: SBO:0000176
modifier: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR S4TASE1ly
kinetic law: MODEL1310110054#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is: SBO:0000176
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.1.6.12
reactant: MODEL1310110054#
modifier: MODEL1310110054#
name: N-acetylgalactosamine-4-sulfatase, lysosomal

metaM pnto R c
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: SBO:0000247
boundary condition: false
is: HMDB00210
is: CHEBI:7916
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
name: (R)-Pantothenate

http://identifiers.org/biomodels.db/MODEL1310110054#_a161d2be_2f91_4431_8f32_111f11f0ae9e
is encoded by: hsa:517
has part: Q06055
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000297
type: Species
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2

metaR SMS
reactant: MODEL1310110054#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.27
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
product: MODEL1310110054#
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
name: Sphingomyelin synthase (homo sapiens)
is: SBO:0000176

metaR UMPK6
type: Reaction
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (dCTP)
modifier: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000269
reversible: true
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110054#

metaR FAOXC16BRx
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16br)x
type: Reaction

metaR ATPS4m
is version of: http://identifiers.org/ec-code/3.6.4.6
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.3.14
product: MODEL1310110054#
name: ATP synthase (four protons for one ATP)
fast: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (513.1 and 498.2 and 506.1 and 509.2 and 514.1 or 498.2 and 513.2 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 514.2 and 506.1 or 498.2 and 513.2 and 506.1 and 509.2 and 514.1 or 513.2 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 498.1 and 506.1 and 509.2 and 514.1 or 513.1 and 498.2 and 514.2 and 506.1 and 509.2 or 513.1 and 498.2 and 509.1 and 506.1 and 514.1 or 498.2 and 509.1 and 513.2 and 506.1 and 514.1 or 513.2 and 498.1 and 506.1 and 509.2 and 514.1 or 513.2 and 514.2 and 506.1 and 509.2 and 498.3 or 513.2 and 506.1 and 509.2 and 498.3 and 514.1 or 513.1 and 509.1 and 506.1 and 498.3 and 514.1 or 509.1 and 513.2 and 514.2 and 506.1 and 498.3 or 513.1 and 498.2 and 509.1 and 514.2 and 506.1 or 513.1 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 506.1 and 514.1 or 513.1 and 506.1 and 509.2 and 498.3 and 514.1 or 509.1 and 513.2 and 506.1 and 498.3 and 514.1 or 513.1 and 514.2 and 506.1 and 509.2 and 498.3 or 509.1 and 513.2 and 498.1 and 506.1 and 514.1 or 513.1 and 509.1 and 514.2 and 506.1 and 498.3 or 498.2 and 509.1 and 513.2 and 514.2 and 506.1 or 509.1 and 513.2 and 498.1 and 514.2 and 506.1) and (10632.1 and 4905.1 and 10476.1 and 9551.3 and 522.5 and 516.2 and 521.1 and 515.1 or 518.3 and 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 9551.3 and 522.3 or 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 517.2 and 9551.2 and 522.3 or 10632.1 and 4905.1 and 10476.1 and 522.5 and 9551.2 and 518.2 and 521.1 and 515.1 or 4905.1 and 515.2 and 10476.2 and 516.2 and 521.1 and 10632.1 and 9551.3 and 522.5 or 518.3 and 4905.1 and 9551.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 522.4 or 10632.1 and 4905.1 and 10476.1 and 9551.1 and 522.2 and 515.2 and 518.2 and 521.1 or 518.3 and 10632.1 and 4905.1 and 10476.1 and 515.3 and 9551.2 and 522.4 and 521.1 or 10632.1 and 4905.1 and 10476.1 and 515.3 and 522.2 and 9551.3 and 518.2 and 521.1 or 4905.1 and 9551.1 and 10476.2 and 522…
is version of: http://identifiers.org/ec-code/3.6.1.14
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is described by: ECO:0000134
reversible: false
is: SBO:0000185

metaM HC02149 c
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:28867
boundary condition: false
type: Species
name: O-Propanoylcarnitine
initial concentration: 1.0
is: SBO:0000247

metaR r1365
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110054#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110054#
is: SBO:0000185
name: Vesicular transport
reactant: MODEL1310110054#

metaR r1585
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110054#
fast: false
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM pail34p hs c
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
is: SBO:0000247
is: CHEBI:57658
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_eae74a81_fb50_4d3a_8884_2095a6845449
is encoded by: hsa:5286
constant: false
boundary condition: true
initial concentration: NaN
is: O00443
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: PIK3C2A

http://identifiers.org/biomodels.db/MODEL1310110054#_bcb64038_c0e8_4b53_9514_7c2bae842bad
constant: false
is encoded by: hsa:2618
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is: P22102
name: GART
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_c691305f_e8b9_4dca_83ed_1273d4c4d746
is: P22304
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
name: IDS
initial amount: NaN
is encoded by: hsa:3423
boundary condition: true

metaR GTHP
fast: false
is described by: ECO:0000134
modifier: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.12
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
reactant: MODEL1310110054#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.9
kinetic law: MODEL1310110054#
name: glutathione peroxidase
reversible: true
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.11.1.15

metaR r2114
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reactant: MODEL1310110054#
reversible: true
type: Reaction
modifier: MODEL1310110054#
is: SBO:0000185
product: MODEL1310110054#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r2113
kinetic law: MODEL1310110054#
is: SBO:0000185
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110054#
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110054#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_70408f3b_9c80_4c6a_b9b3_2f860cd92bfc
is: SBO:0000252
is encoded by: hsa:522
name: ATP5J
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is: Q6NZ59
boundary condition: true
has only substance units: false

metaR DNDPt21m
product: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
is described by: ECO:0000269
name: dTDP transport via ADP antiport
type: Reaction
kinetic law: MODEL1310110054#
fast: false
modifier: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaM glyc3p c
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
initial amount: NaN
is: C00093
constant: false
name: Glycerol 3-phosphate
has only substance units: false
boundary condition: false
is: HMDB00126
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:57597

metaM adn e
is: CHEBI:16335
name: Adenosine
boundary condition: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
is: C00212
is: HMDB00050
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_36ead1b9_8bc1_4e3d_adc0_19883aae10aa
type: Species
is: SBO:0000252
is encoded by: hsa:5634
initial amount: NaN
is: P11908
has only substance units: false
name: PRPS2
constant: false
boundary condition: true
initial concentration: NaN

metaR GLXtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
name: glyoxylate transport, mitochondrial
type: Reaction
kinetic law: MODEL1310110054#
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110054#
is: SBO:0000185
product: MODEL1310110054#

metaM crm hs c
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:52639
boundary condition: false
constant: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
name: N-acylsphingosine
initial concentration: 1.0

metaR HEX4
product: MODEL1310110054#
name: hexokinase (D-mannose:ATP)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.1
modifier: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.1.2

metaR r1586
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reversible: true
product: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110054#_b2cee5dd_5e4f_4b24_85d7_7cae3d247fab
has only substance units: false
is: Q5K4L6
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:11000
constant: false
initial concentration: NaN
boundary condition: true
type: Species
name: SLC27A3

http://identifiers.org/biomodels.db/MODEL1310110054#_364a6bde_1efe_487f_b4c4_333fcfe0390f
initial amount: NaN
name: PMM1
is: A8K003
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:5372
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_a6b11465_8636_4d29_8699_3f1507bf52eb
constant: false
is: B4DIR8
has only substance units: false
is: SBO:0000252
type: Species
name: SLC13A3
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:64849

metaR P4508B13r
reversible: false
is described by: ECO:0000269
fast: false
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.14.13.95
modifier: MODEL1310110054#
name: sterol 12-alpha-hydroxylase (nadh)
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
type: Reaction
product: MODEL1310110054#
is: SBO:0000176

metaR r0809
reversible: true
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110054#
fast: false
is described by: ECO:0000000
name: Facilitated diffusion
modifier: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:
type: Reaction
kinetic law: MODEL1310110054#

metaR DADAe
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
is described by: ECO:0000269
is: SBO:0000176
name: Deoxyadenosine deaminase, extracellular
kinetic law: MODEL1310110054#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.4
modifier: MODEL1310110054#
product: MODEL1310110054#
reversible: false
reactant: MODEL1310110054#

metaR PRGNLONEtm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
is: SBO:0000185
reactant: MODEL1310110054#
product: MODEL1310110054#
name: pregnenolone intracellular transport
kinetic law: MODEL1310110054#
is described by: ECO:0000000
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_bcae43fc_f412_4200_a1b7_4fd9889c683c
initial amount: NaN
boundary condition: true
name: NDUFV3
is: P56181
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:4731
is: SBO:0000252
constant: false

metaM gly m
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: Glycine
has only substance units: false
is: C00037
constant: false
is: CHEBI:15428
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
initial amount: NaN
type: Species
is: HMDB00123

metaM 4mop m
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
name: 4-methyl-2-oxopentanoate
type: Species
is: CHEBI:17865
is: HMDB00695
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false

metaM betald c
is: HMDB01252
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
initial amount: NaN
is: CHEBI:15710
initial concentration: 1.0
is: SBO:0000247
name: betaine aldehyde
constant: false

metaR r1587
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000185
fast: false

metaM l2fn2m2masn g
has only substance units: false
is: SBO:0000247
notes: FORMULA: C68H113N4O49X CHARGE: 0
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
is: CHEBI:28067
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
type: Species

metaR HEX1
is version of: http://identifiers.org/ec-code/2.7.1.2
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110054#
name: hexokinase (D-glucose:ATP)
reactant: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.1
modifier: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110054#
is described by: ECO:0000134

metaR r2116
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185
reversible: true
modifier: MODEL1310110054#
is described by: ECO:0000000
product: MODEL1310110054#

metaR DNDPt15m
product: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110054#
name: dUDP transport via dGDP antiport
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#

metaR DOLP Uter
fast: false
reversible: false
is: SBO:0000176
name: dolichol phosphate flippase (uterus)
product: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110054#_5bc6d3c1_dddd_4d04_a7a4_274e97361adf
is encoded by: hsa:M68895
initial concentration: NaN
name: _M68895_1_c
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false

metaR r1364
fast: false
product: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
is: SBO:0000185
name: Vesicular transport
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR LEUTA
kinetic law: MODEL1310110054#
is: SBO:0000176
reactant: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
type: Reaction
modifier: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.6.1.42
reversible: true
name: leucine transaminase
is described by: ECO:0000269

metaM fdp c
type: Species
has only substance units: false
is: CHEBI:16905
initial concentration: 1.0
is: HMDB01058
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3647
name: D-Fructose 1,6-bisphosphate
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
initial amount: NaN
constant: false
is: C00354
boundary condition: false

metaM ile L m
boundary condition: false
constant: false
is: HMDB00172
name: L-isoleucine
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:17191
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_d6945dd3_010e_4234_a8f2_9b2641efdb75
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: Q5T4Y1
is encoded by: hsa:6487
constant: false
is: SBO:0000252
name: ST3GAL3

metaR RE3524R
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
product: MODEL1310110054#
reversible: true
type: Reaction
reactant: MODEL1310110054#
fast: false
name: RE3524
kinetic law: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110054#_b8a0e03c_24bf_43d9_aae9_39df4a2cbfc6
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: ND2
constant: false
is encoded by: hsa:4536
is: Q7GXY9

metaR r1588
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110054#
reversible: true
reactant: MODEL1310110054#
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r2115
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reactant: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110054#

metaR GTHO
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
reversible: false
name: glutathione oxidoreductase
modifier: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
is described by: ECO:0000254
fast: false
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.8.1.7
is: SBO:0000176

metaR DDPGAm
reactant: MODEL1310110054#
product: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
is: SBO:0000176
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
kinetic law: MODEL1310110054#
is described by: ECO:0000000
fast: false
type: Reaction

metaM pd3 c
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
name: Previtamin D3
constant: false
is: HMDB06500

metaM 5adtststerones e
is: SBO:0000247
is: HMDB06278
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
name: 5alpha-Dihydrotestosterone sulfate

metaM ksi deg41 l
constant: false
is: HMDB00143
is: SBO:0000247
has only substance units: false
notes: FORMULA: C34H58N2O26 CHARGE: 0
initial amount: NaN
is: CHEBI:12936
name: keratan sulfate I, degradation product 41
initial concentration: 1.0
type: Species
boundary condition: false

metaR RE3346C
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: RE3346
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110054#
modifier: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reversible: true
fast: false
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110054#_b9a4b7c5_73e3_40f5_925f_41fe11decece
constant: false
is: SBO:0000297
initial concentration: NaN
has part: E9KL44
has only substance units: false
boundary condition: true
is encoded by: hsa:3030
name: HADHA:HADHB
initial amount: NaN
is encoded by: hsa:3032
type: Species
has part: P55084

http://identifiers.org/biomodels.db/MODEL1310110054#_e362ae69_5d20_48c4_a9fd_2782e75b3f9e
is: SBO:0000252
boundary condition: true
type: Species
name: _AA278423_1_m
constant: false
is encoded by: hsa:AA278423
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_b46aa076_22e7_4d62_a99e_7baad8e4b80c
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10005
is: O14734
is: SBO:0000252
name: ACOT8

metaM cs e deg4 l
is: CHEBI:15748
constant: false
has only substance units: false
notes: FORMULA: C31H46NO38S4 CHARGE: -5
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4
boundary condition: false
is: HMDB00127

http://identifiers.org/biomodels.db/MODEL1310110054#_9da86a22_e158_4ee3_8d7a_6b567b57c81c
is: O43677
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: NDUFC1
is encoded by: hsa:4717
type: Species
boundary condition: true
initial concentration: NaN

metaR r2110
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110054#
fast: false
modifier: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000000
reversible: true

metaR LEUKTRA4t
name: leukotriene A4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
product: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#
is described by: ECO:0000269
type: Reaction
fast: false

metaR 3MOPte
reversible: true
name: Transport of 3-methyl-2-oxopentanoate
is described by: ECO:0000134
product: MODEL1310110054#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#

metaM mgacpail hs r
is: C00249
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
is: HMDB00220
constant: false
is: CHEBI:7896
initial concentration: 1.0
type: Species

metaR CYTK14n
fast: false
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110054#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,CTP),nuclear
is: SBO:0000176
reactant: MODEL1310110054#
type: Reaction

metaR LEUt4
fast: false
kinetic law: MODEL1310110054#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
modifier: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: (81539.1) or (84889.1) or (6520.1) or (6542.1) or (6541.1) or (11254.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10391915,PMID:10891391,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:1376926,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
name: L-leucine transport in via sodium symport

metaM dgsn c
name: Deoxyguanosine
is: SBO:0000247
is: C00330
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:17172
is: HMDB00085
type: Species
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_21b9770f_b30d_4cd2_b6c4_af0b74161c4c
name: ITPKA
constant: false
boundary condition: true
is encoded by: hsa:3706
is: SBO:0000252
has only substance units: false
is: P23677
initial amount: NaN
type: Species
initial concentration: NaN

metaR CSPG Atly
is: SBO:0000185
reactant: MODEL1310110054#
name: chondroitin sulfate A transport, extracellular to lysosome
is described by: ECO:0000000
type: Reaction
product: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
fast: false

metaR OLEICFATPtc
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

metaR r1589
is described by: ECO:0000000
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110054#
is: SBO:0000185
kinetic law: MODEL1310110054#
product: MODEL1310110054#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_75b1a1f7_0c85_48f0_8871_24baab276534
name: PDE6G
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5148
initial amount: NaN
constant: false
is: P18545
type: Species
initial concentration: NaN
boundary condition: true

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaM crm hs g
initial concentration: 1.0
type: Species
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
name: N-acylsphingosine
is: SBO:0000247
boundary condition: false
is: CHEBI:52639
has only substance units: false
initial amount: NaN
constant: false

metaR ADNtm
reversible: true
name: adenosine facilated transport in mitochondria
kinetic law: MODEL1310110054#
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
reactant: MODEL1310110054#
is: SBO:0000185
product: MODEL1310110054#
modifier: MODEL1310110054#

metaM n2m2masn g
constant: false
boundary condition: false
is: C11530
is: SBO:0000247
notes: FORMULA: C50H83N4O35X CHARGE: 0
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_9fc2e6f3_a893_45a7_8773_adbfa1551563
is encoded by: hsa:U37519
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: _U37519_1_e
type: Species
initial concentration: NaN
constant: false
has only substance units: false

metaM dgdp m
has only substance units: false
is: CHEBI:58595
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
name: dGDP(2-)
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
type: Species
is: HMDB00960
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_e3c6262d_ac36_49d0_911a_57a7bd8f747b
initial amount: NaN
name: HSD17B4
initial concentration: NaN
is: E9PB82
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:3295
has only substance units: false
boundary condition: true

metaM ctp e
boundary condition: false
is: CHEBI:37563
constant: false
name: CTP(4-)
is: HMDB00082
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063

metaR THRSERNaEx
is: SBO:0000185
product: MODEL1310110054#
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
name: L-serine/L-threonine Na-dependent exchange (Thr-L in)
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
reactant: MODEL1310110054#
type: Reaction

metaM 5adtststerones c
constant: false
is: HMDB06278
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
name: 5alpha-Dihydrotestosterone sulfate

metaR PPBNGS
fast: false
name: porphobilinogen synthase
notes: GENE_ASSOCIATION: (210.1) or (210.2) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.24 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
product: MODEL1310110054#
modifier: MODEL1310110054#
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/4.2.1.24
kinetic law: MODEL1310110054#
is described by: ECO:0000269
type: Reaction
reversible: false

metaM atp c
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00538
has only substance units: false
is: SBO:0000247
is: C00002
name: ATP(4-)
is: CHEBI:30616
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_99ce074a_2264_40db_9f3c_b0ef3980fb45
type: Species
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is encoded by: hsa:506
initial amount: NaN
is encoded by: hsa:509
initial concentration: NaN
has part: P30049
is encoded by: hsa:514
constant: false
is: SBO:0000297
has only substance units: false
has part: P36542
is encoded by: hsa:498
has part: A8K092
boundary condition: true
has part: P56381
is encoded by: hsa:513
has part: P06576

metaR FAOXC164C165x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)x
type: Reaction

metaR FAEL204
type: Reaction
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
kinetic law: MODEL1310110054#
is: SBO:0000176
name: fatty-acyl-CoA elongation (n-C20:4CoA)
fast: false
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#

metaR NADtpu
fast: false
name: NAD transporter, peroxisome
product: MODEL1310110054#
reversible: false
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
reactant: MODEL1310110054#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_6d394821_4ba2_4a5b_9337_fbfa41176821
name: COASY
type: Species
boundary condition: true
is encoded by: hsa:80347
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q13057
constant: false
initial concentration: NaN

metaM dgdp n
is: SBO:0000247
constant: false
name: dGDP(2-)
initial concentration: 1.0
is: CHEBI:58595
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: HMDB00960
has only substance units: false

metaR BILDGLCURtr
product: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
reversible: true
is: SBO:0000185
reactant: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#
name: glucuronidated compound transport

metaR r2112
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110054#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110054#
is described by: ECO:0000000
modifier: MODEL1310110054#
is: SBO:0000185
product: MODEL1310110054#

metaR ARACHCPT1
fast: false
name: carnitine transferase
reversible: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110054#_83afd465_9f23_4891_8352_85e32fd22395
boundary condition: true
is encoded by: hsa:8639
initial amount: NaN
is: Q16853
constant: false
name: AOC3
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR FAEL205
reactant: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
reversible: false
product: MODEL1310110054#
is: SBO:0000176
name: fatty-acyl-CoA elongation (n-C20:5CoA)

http://identifiers.org/biomodels.db/MODEL1310110054#_c0bc3c35_55d4_4b6c_a48d_2cf542e6bf20
boundary condition: true
constant: false
is encoded by: hsa:R14373
has only substance units: false
type: Species
name: _R14373_1_x
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR 35CGMPtn
product: MODEL1310110054#
type: Reaction
name: 35cGMP nuclear transport
is: SBO:0000185
kinetic law: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
reactant: MODEL1310110054#
reversible: true

metaR CSEPASEly
is: SBO:0000176
type: Reaction
product: MODEL1310110054#
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)

http://identifiers.org/biomodels.db/MODEL1310110054#_2c417b08_d6e8_4509_9868_5ccaa74df5d2
constant: false
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: P83881
is encoded by: hsa:6173
is: SBO:0000252
name: RPL36A
initial concentration: NaN

metaM 3hexdtetcoa x
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
name: 3,7,10,13-hexadecatetraenoylcoa
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB02288
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_8c0b48bd_87cf_4834_821d_681646384856
initial concentration: NaN
boundary condition: true
name: MVK
constant: false
has only substance units: false
initial amount: NaN
is: B2RDU6
is encoded by: hsa:4598
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_94638c1e_8746_49d4_b728_002d0ee8b351
initial amount: NaN
type: Species
name: GGT7
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2686
is: A0PJJ9
is: SBO:0000252
boundary condition: true

metaR r2111
product: MODEL1310110054#
is: SBO:0000185
modifier: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110054#
fast: false
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_43666c2e_c538_4aa4_b64a_dc3e0f101e29
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
name: INPP5E
constant: false
initial concentration: NaN
is: Q9NRR6
boundary condition: true
is encoded by: hsa:56623

metaR SERDGLYexR
reversible: true
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
name: D-Serine/Glycine reversible exchange
is described by: ECO:0000304
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
is: SBO:0000185
modifier: MODEL1310110054#

metaM ctp c
is: CHEBI:37563
is: SBO:0000247
type: Species
is: C00063
boundary condition: false
is: HMDB00082
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
name: CTP

metaR RE0958E
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
kinetic law: MODEL1310110054#
type: Reaction
reversible: true
fast: false
product: MODEL1310110054#
modifier: MODEL1310110054#
name: RE0958
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.17
is: SBO:0000176

metaR ARACHCPT2
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
fast: false
kinetic law: MODEL1310110054#
name: carnitine transferase
reactant: MODEL1310110054#
modifier: MODEL1310110054#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
is described by: ECO:0000000

metaR RE1845C
reversible: true
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000000
name: RE1845
fast: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
product: MODEL1310110054#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110054#

metaR ABO6g
is: SBO:0000176
type: Reaction
product: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.37
reversible: false
reactant: MODEL1310110054#
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
modifier: MODEL1310110054#
is described by: ECO:0000269
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_c7034023_870e_412c_9bfc_f92caa96e201
name: SLC26A6
boundary condition: true
is: Q9NQU1
initial concentration: NaN
type: Species
is encoded by: hsa:65010
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR ALAGLNNaEx
name: L-alanine/L-glutamine Na-dependent exchange (Ala-L in)
fast: false
is: SBO:0000185
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
type: Reaction
reversible: false
is described by: ECO:0000269
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaM gpail hs c
is: CHEBI:17049
has only substance units: false
type: Species
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247

metaR r1658
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110054#

metaR RNDR1
name: ribonucleoside-diphosphate reductase (ADP)
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110054#
fast: false
product: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
is described by: ECO:0000254
is: SBO:0000176

metaR r2532
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
product: MODEL1310110054#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110054#

metaR XOL27OHtm
kinetic law: MODEL1310110054#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
name: 27 hydroxy cholesterol transport

metaM 3otdcoa m
initial amount: NaN
name: 3-Oxotetradecanoyl-CoA
boundary condition: false
type: Species
is: CHEBI:28726
initial concentration: 1.0
has only substance units: false
is: HMDB03935
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
constant: false
is: SBO:0000247

metaR GALACGLCGALGBSIDEte
product: MODEL1310110054#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110054#
reversible: true
name: galacglcgalgbside hs transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
kinetic law: MODEL1310110054#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_ba4e8232_2526_4903_a3b2_f954eebbb820
is: SBO:0000252
type: Species
is: P04179
name: SOD2
boundary condition: true
initial amount: NaN
is encoded by: hsa:6648
constant: false
initial concentration: NaN
has only substance units: false

metaR FAOXC164C165m
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

metaM CE2435 m
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
initial concentration: 1.0
constant: false
name: trans,cis-deca-2,4-dienoyl-CoA
boundary condition: false
is: CHEBI:57795

http://identifiers.org/biomodels.db/MODEL1310110054#_d5fc6c3c_e73f_4b01_a7be_bcead509d262
type: Species
is: Q53TV9
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
name: RPE
boundary condition: true
has only substance units: false
is encoded by: hsa:6120

metaR r1433
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
is: SBO:0000176
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110054#_c53cbba3_8f36_4753_a552_a7c1a6f1fbeb
is: B4DK61
name: ACOX1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:51
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
constant: false

metaR r1659
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110054#
product: MODEL1310110054#
modifier: MODEL1310110054#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110054#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM adn m
is: CHEBI:16335
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00050
notes: FORMULA: C10H13N5O4 CHARGE: 0 INCHI: InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
type: Species
is: SBO:0000247
name: adenosine

metaR GLNALANaEx
is described by: ECO:0000269
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
product: MODEL1310110054#
reversible: false
reactant: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
fast: false
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)

metaM ins c
is: C00294
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:17596
initial concentration: 1.0
is: HMDB00195
constant: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
initial amount: NaN
name: Inosine

http://identifiers.org/biomodels.db/MODEL1310110054#_21dafec0_d5a8_4a88_a558_ae8fd8006e20
constant: false
initial amount: NaN
is: SBO:0000297
boundary condition: true
has only substance units: false
type: Species
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
initial concentration: NaN
is encoded by: hsa:7991

metaR NACHEX22ly
type: Reaction
kinetic law: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110054#
reactant: MODEL1310110054#
modifier: MODEL1310110054#

metaR GLCt2 2
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:
reactant: MODEL1310110054#
is: SBO:0000185
kinetic law: MODEL1310110054#
name: D-glucose transport in via proton symport
product: MODEL1310110054#
reversible: true
fast: false

metaR EX pydx LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Pyridoxal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_96c0db34_ab81_4d8d_b5be_7ba584c9a553
boundary condition: true
constant: false
has part: P56134
has only substance units: false
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:9551
type: Species
initial amount: NaN
is encoded by: hsa:522
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2

metaR FRDPtcr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
fast: false
reactant: MODEL1310110054#
is described by: ECO:0000134
reversible: true
product: MODEL1310110054#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
kinetic law: MODEL1310110054#
type: Reaction
is: SBO:0000185

metaR PI45P3K
is: SBO:0000176
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.1.153
fast: false
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
modifier: MODEL1310110054#
reversible: false
kinetic law: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110054#_245983bd_984c_49d7_8dc5_ce651e7c9ff9
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10449
name: ACAA2
boundary condition: true
type: Species
has only substance units: false
constant: false
is: P42765

metaR GLB1
kinetic law: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NJ
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110054#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110054#
name: Beta-galactosidase
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110054#

metaM 3hexdtetcoa m
initial amount: NaN
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
name: 3,7,10,13-hexadecatetraenoylcoa
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB02288
constant: false
is: SBO:0000247
type: Species

metaR r0926
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Postulated transport reaction
reactant: MODEL1310110054#
reversible: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#

metaM gly e
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00123
notes: FORMULA: C2H5NO2 CHARGE: 0
name: Glycine
initial concentration: 1.0
is: C00037
has only substance units: false
constant: false
is: CHEBI:3339

metaR r0801
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
type: Reaction
kinetic law: MODEL1310110054#
is: SBO:0000185
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110054#
reactant: MODEL1310110054#

metaR MMMm
is version of: http://identifiers.org/ec-code/5.4.99.2
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
reversible: true
fast: false
product: MODEL1310110054#
is described by: ECO:0000269
name: methylmalonyl-CoA mutase
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
is: SBO:0000176

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaR CRNt
name: L-carnitine reversible transport
is: SBO:0000185
type: Reaction
reactant: MODEL1310110054#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
fast: false
product: MODEL1310110054#
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_03b65dea_5fc7_47f7_984a_a2457d180537
name: OGDH
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: B4E3E9
is: SBO:0000252
is encoded by: hsa:4967
boundary condition: true
initial amount: NaN

metaR r1435
reactant: MODEL1310110054#
product: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
name: Transport reaction
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:

metaM atp e
name: ATP(4-)
type: Species
constant: false
is: HMDB00538
is: SBO:0000247
is: CHEBI:57299
is: C00002
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM acgal g
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
is: SBO:0000247
boundary condition: false
is: CHEBI:28037
type: Species
initial amount: NaN
name: N-acetyl-D-galactosamine
is: HMDB00212
constant: false
initial concentration: 1.0
has only substance units: false

metaR r1580
type: Reaction
product: MODEL1310110054#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110054#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110054#
is: SBO:0000185

metaR MALTSULtm
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000269
modifier: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
name: Malate:thiosulfate antiport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

metaR r2118
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110054#
product: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110054#_70b05548_7d69_405c_be27_d67726370b23
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AF080579
initial amount: NaN
name: _AF080579_1_c
constant: false
initial concentration: NaN
boundary condition: true
type: Species

metaR PItx
fast: false
is: SBO:0000185
product: MODEL1310110054#
is described by: ECO:0000000
reversible: true
name: Phosphate transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
type: Reaction
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#

metaR r1654
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reversible: true
is: SBO:0000185
reactant: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM HC00229 e
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28189
initial amount: NaN
has only substance units: false
name: Isomaltose
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252

http://identifiers.org/biomodels.db/MODEL1310110054#_44f19476_321c_4209_ab07_7b4e52800b56
initial amount: NaN
is encoded by: hsa:8875
is: SBO:0000297
name: VNN3:VNN2:VNN1
boundary condition: true
is encoded by: hsa:55350
has part: O95498
initial concentration: NaN
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_61433969_5366_4511_a6b9_5640225bb606
type: Species
is encoded by: hsa:1103
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: CHAT
initial concentration: NaN
is: P28329
boundary condition: true
constant: false

metaM atp m
is: SBO:0000247
is: C00002
boundary condition: false
is: CHEBI:57299
name: ATP(4-)
is: HMDB00538
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_a2a443e0_0a9e_434c_aaf2_f1a58f2b264c
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:6319
has only substance units: false
name: SCD
boundary condition: true
is: O00767
type: Species
initial concentration: NaN

metaM adrncoa c
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: adrenyl coenzyme A
has only substance units: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205480
is: C16170
constant: false

metaR r1581
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110054#
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction

metaR r2535
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110054#
type: Reaction

metaR GALASE10ly
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000176
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_0597a4c2_f909_4f8b_994d_809b7f34016e
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: ACSS1
initial amount: NaN
boundary condition: true
is encoded by: hsa:84532
is: Q9NUB1

metaR H7ET2er
name: H7 phosphoethanolaminyl transferase, endoplasmic reticulum
reactant: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: (5281.1) and (54872.1) or (5281.2) and (54872.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15632136 NOTES:NCD
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.1
is described by: ECO:0000000
product: MODEL1310110054#

metaR HGNTOR
is described by: ECO:0000269
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
reversible: false
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.13.11.5
modifier: MODEL1310110054#
fast: false
type: Reaction
product: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176

metaR r2117
is: SBO:0000185
reversible: true
type: Reaction
fast: false
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110054#
product: MODEL1310110054#

metaR r1655
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000000

metaR ACHEe
is: SBO:0000176
is described by: ECO:0000269
reversible: false
product: MODEL1310110054#
modifier: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
name: Acetylcholinesterase
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.7
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ

metaR BDMT L
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reversible: false
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.142
reactant: MODEL1310110054#
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (liver)
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD

metaM ctp n
is: HMDB00082
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: CTP(4-)
is: CHEBI:37563
type: Species
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: SBO:0000247
constant: false

metaR RETNt
product: MODEL1310110054#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110054#
is described by: ECO:0000000
name: retinoic acid transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
fast: false
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_96ea1f4a_b03f_4549_84f7_eb4379b55640
name: DCK
initial amount: NaN
constant: false
is: P27707
is encoded by: hsa:1633
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM CE2416 x
name: (2R,6S,10S)-pristanate
is: SBO:0000247
boundary condition: false
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)/p-1/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: CE2416
has only substance units: false
is: CHEBI:57923
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false

metaR RE1810M
name: RE1810
kinetic law: MODEL1310110054#
is described by: ECO:0000000
product: MODEL1310110054#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
reactant: MODEL1310110054#
fast: false
reversible: true

metaR r2534
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
product: MODEL1310110054#
reversible: true
is described by: ECO:0000000
is: SBO:0000185

metaR GLYPHEHYc
reactant: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
name: hydrolysis of glycylphenylalanine
type: Reaction
fast: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176

metaR r1656
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
modifier: MODEL1310110054#

metaR ACOAO7p
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
kinetic law: MODEL1310110054#
fast: false
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
reactant: MODEL1310110054#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110054#
is: SBO:0000176
product: MODEL1310110054#

metaR R group phosphotase 1
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110054#
name: R group phosphotase 1
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reactant: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
is described by: ECO:0000000

metaM itacon m
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
name: itaconate(2-)
initial amount: NaN
is: CHEBI:17240
is: HMDB02092
boundary condition: false

metaR GALACGLCGALGBSIDEtg
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reactant: MODEL1310110054#
name: galacglcgalgbside hs intracellular transport
reversible: true

metaR FAOXC164C143m
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)m
type: Reaction

metaR ITPtn
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: ITP nuclear transport
type: Reaction
fast: false
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000185
reversible: true
reactant: MODEL1310110054#

metaR r1583
is described by: ECO:0000000
kinetic law: MODEL1310110054#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110054#

metaR ME2m
reversible: false
fast: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.40
name: malic enzyme (NADP), mitochondrial
kinetic law: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.1.1.38
product: MODEL1310110054#

metaR RADH3
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: retinal dehydrogenase
reversible: true
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:11606944 NOTES:IT
product: MODEL1310110054#
type: Reaction

metaM ctp m
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00082
is: CHEBI:37563
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
name: CTP(4-)
type: Species

metaR NMNATr
is version of: http://identifiers.org/ec-code/2.7.7.1
is described by: ECO:0000269
type: Reaction
name: nicotinamide-nucleotide adenylyltransferase
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is: SBO:0000176
fast: false
product: MODEL1310110054#
reactant: MODEL1310110054#

metaR r2119
type: Reaction
modifier: MODEL1310110054#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110054#_ce4d766c_d891_4e70_a78d_c338e0ce272b
has only substance units: false
boundary condition: true
has part: O15270
type: Species
has part: O15269
initial concentration: NaN
is encoded by: hsa:9517
is: SBO:0000297
name: SPTLC1:SPTLC2
initial amount: NaN
is encoded by: hsa:10558
constant: false

metaR r1657
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000

metaR RNDR2
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
product: MODEL1310110054#
type: Reaction
is described by: ECO:0000254
reactant: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.17.4.1
name: ribonucleoside-diphosphate reductase (GDP)
reversible: false
fast: false
modifier: MODEL1310110054#

metaR r1584
kinetic law: MODEL1310110054#
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110054#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110054#
type: Reaction

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

metaM acgal c
has only substance units: false
boundary condition: false
name: N-acetyl-D-galactosamine
is: HMDB00212
type: Species
is: CHEBI:28037
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132

metaR RADH2
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
product: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
name: retinal dehydrogenase (NADPH)

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaM udpacgal l
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00304
initial amount: NaN
constant: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
name: UDP-N-acetyl-D-galactosamine(2-)
is: CHEBI:57847

http://identifiers.org/biomodels.db/MODEL1310110054#_09f03b02_fc5c_4a64_8d56_b478c51dff1b
name: RPIA
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: P49247
is encoded by: hsa:22934
initial amount: NaN
constant: false
type: Species
boundary condition: true

metaM cs e deg5 l
is: HMDB00868
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:57737
notes: FORMULA: C31H47NO35S3 CHARGE: -4
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_380e2ff6_4780_450b_a6c1_7a44dde44129
constant: false
boundary condition: true
initial amount: NaN
name: QPRT
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q15274
is encoded by: hsa:23475

http://identifiers.org/biomodels.db/MODEL1310110054#_984f6441_de9d_492c_8b3a_4d6476d42e9a
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:30
is: Q96CA6
constant: false
is: SBO:0000252
type: Species
name: ACAA1
has only substance units: false
boundary condition: true

metaR GMPtn
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
is: SBO:0000185
type: Reaction
name: GMP nuclear transport
product: MODEL1310110054#
kinetic law: MODEL1310110054#

metaR r2525
type: Reaction
reversible: true
product: MODEL1310110054#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000000

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_f2572cda_e07e_484a_8f19_3d0b53341bd0
type: Species
initial concentration: NaN
name: _AL048840_1_c
has only substance units: false
is encoded by: hsa:AL048840
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false

metaR r1665
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110054#
fast: false
name: Y+LAT2 Utilized transport
reversible: true
product: MODEL1310110054#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#

metaR G14T12g
is: SBO:0000176
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#

metaR CLFORtex
reactant: MODEL1310110054#
reversible: false
name: chloride transport via formate countertransport
fast: false
type: Reaction
kinetic law: MODEL1310110054#
is: SBO:0000185
is described by: ECO:0000304
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
modifier: MODEL1310110054#

metaR DALAt2r
is: SBO:0000185
modifier: MODEL1310110054#
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
name: D-alanine transport via proton symport
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_4f2f82d4_2ddf_4019_b0f5_d322890cea34
initial concentration: NaN
name: ALPL
has only substance units: false
is: B7Z4Y6
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:249
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_cda423e4_e184_4f5b_969b_bc62b32307ce
initial amount: NaN
type: Species
name: IDH2
is: SBO:0000252
is: P48735
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3418
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_4cd7c7f6_1657_4728_b46c_6858a746b7d4
constant: false
has part: P57054
is encoded by: hsa:5277
is encoded by: hsa:5279
initial amount: NaN
is encoded by: hsa:51227
is encoded by: hsa:9091
has part: B2RAU6
has only substance units: false
is: SBO:0000297
boundary condition: true
type: Species
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial concentration: NaN

metaM 3pg c
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00807
is: C00197
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3497
is: SBO:0000247
name: 3-Phospho-D-glycerate
boundary condition: false
is: CHEBI:58272

metaM 2mcit e
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00379
type: Species
initial amount: NaN
is: CHEBI:15598
has only substance units: false
name: 2-methylcitrate(3-)

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR GALASE12ly
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
fast: false
product: MODEL1310110054#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR AG13T1g
type: Reaction
product: MODEL1310110054#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110054#
is: SBO:0000176
modifier: MODEL1310110054#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149

metaR ACOAD1fm
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110054#
fast: false
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
reversible: false

metaM CE5854 e
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:27485
initial amount: NaN
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
has only substance units: false
name: gama-CEHC-glucuronide
is: HMDB02710
constant: false
boundary condition: false

metaR r2526
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
product: MODEL1310110054#
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#

metaR 2OXOADOXm
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.61
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
product: MODEL1310110054#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
is version of: http://identifiers.org/ec-code/1.2.4.2
is described by: ECO:0000304
modifier: MODEL1310110054#

metaR r1664
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: true
type: Reaction
fast: false
product: MODEL1310110054#
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#

metaM xol7ah c
initial amount: NaN
is: HMDB06892
name: 7alpha-hydroxy-5beta-cholestan-3-one
type: Species
is: SBO:0000247
is: CHEBI:2290
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
has only substance units: false

metaR GASNASE2ly
type: Reaction
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#
is described by: ECO:0000000
reversible: false
name: glycosylasparaginase, lysosomal
modifier: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.26
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_37287234_a466_446a_bcc7_59c763034a17
is: Q86XP1
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:160851
boundary condition: true
type: Species
has only substance units: false
name: DGKH
initial amount: NaN

metaM estradiol e
is: HMDB00151
boundary condition: false
is: CHEBI:16469
name: estradiol
type: Species
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_659a1299_0b85_446e_bcd2_622af4cab898
is: O95263
is encoded by: hsa:8622
has only substance units: false
type: Species
initial amount: NaN
name: PDE8B
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN

metaM HC02206 c
constant: false
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
name: prostaglandin C1(1-)
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:57399

http://identifiers.org/biomodels.db/MODEL1310110054#_baaa7fa9_e072_4a0a_8535_6f8bdc041739
initial amount: NaN
constant: false
is: SBO:0000252
name: MTMR2
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:8898
is: A6NN98

metaM hdd2coa m
is: HMDB03945
initial amount: NaN
is: C05272
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:61526
name: trans-Hexadec-2-enoyl-CoA
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
initial concentration: 1.0
constant: false
boundary condition: false

metaR S6T12g
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110054#
modifier: MODEL1310110054#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110054#_dd47b1d9_8f4e_4480_b0cc_a8f22f197050
boundary condition: true
is: P42126
name: ECI1
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:1632
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM hxan e
initial amount: NaN
initial concentration: 1.0
name: hypoxanthine
type: Species
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
constant: false
boundary condition: false
is: CHEBI:17368
is: HMDB00157
is: SBO:0000247
has only substance units: false

metaR r1662
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110054#

metaR ASNNm
is described by: ECO:0000254
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (80150.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES:PMID: 11984834 (denotes it as potentially mitochondrial) mm
product: MODEL1310110054#
modifier: MODEL1310110054#
name: L-asparaginase (mitochondrial)
is version of: http://identifiers.org/ec-code/3.5.1.1
is: SBO:0000176
kinetic law: MODEL1310110054#
reversible: false
fast: false
type: Reaction

metaR S6TASE16ly
product: MODEL1310110054#
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true
fast: false
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000000

metaR PPPG9tm
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:14623258 NOTES:NCD. Benzodiazepine receptor PBR see also 17168567
product: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: protoporphyrinogen IX mitochondrial transport
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_b3695217_ccf7_479e_a883_632dd2fd30dd
name: SUCLA2
initial amount: NaN
initial concentration: NaN
is: E5KS60
type: Species
constant: false
boundary condition: true
is encoded by: hsa:8803
has only substance units: false
is: SBO:0000252

metaM pre prot r
is: HMDB03125
is: SBO:0000247
is: CHEBI:16240
name: glycophosphatidylinositol (GPI)-anchored protein precursor
notes: FORMULA: XY CHARGE: 0
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false

metaM orot5p c
is: SBO:0000247
initial amount: NaN
name: Orotidine 5'-phosphate
boundary condition: false
is: C01103
is: CHEBI:57538
type: Species
has only substance units: false
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
constant: false
initial concentration: 1.0
is: HMDB00218

metaR CYTK2n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#
modifier: MODEL1310110054#
name: cytidylate kinase (dCMP),nuclear
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM gluside hs r
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:18368
name: D-glucosyl-N-acylsphingosine

metaM 2mcit c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00379
is: CHEBI:15598
initial amount: NaN
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
boundary condition: false
name: 2-methylcitrate(3-)
constant: false

metaR PROSTGE2t
is described by: ECO:0000269
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000185
reversible: true
product: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
fast: false
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ

metaR RE1804M
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
name: RE1804
fast: false
reversible: true

metaM estradiol c
constant: false
type: Species
boundary condition: false
name: estradiol
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16469
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
has only substance units: false
initial amount: NaN
is: HMDB00151

metaR EX estradiol LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: estradiol exchange
type: Reaction

metaR HXPRT
fast: false
type: Reaction
reactant: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
reversible: false
is version of: http://identifiers.org/ec-code/2.4.2.8
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000269
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_35a5a7ca_1a6a_4813_987d_b9e627bbc0d6
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:5295
boundary condition: true
name: PIK3R1
initial concentration: NaN
initial amount: NaN
is: P27986
has only substance units: false

metaR r0276
is: SBO:0000176
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.2
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.21
modifier: MODEL1310110054#

metaM ddsmsterol r
is: SBO:0000247
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
is: HMDB03896
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:27910
constant: false
name: 7-dehydrodesmosterol
type: Species
has only substance units: false

metaR r1661
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_9ef3fadb_8c0a_4641_94b7_b5bc8c05fbfa
boundary condition: true
is: SBO:0000252
name: PIGP
is encoded by: hsa:51227
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species

metaM hxan c
boundary condition: false
initial amount: NaN
is: HMDB00157
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
constant: false
name: Hypoxanthine
is: C00262
type: Species
is: CHEBI:17368
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM HC02206 e
has only substance units: false
is: CHEBI:57399
initial amount: NaN
name: prostaglandin C1(1-)
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686

metaM ins e
boundary condition: false
constant: false
is: C00294
type: Species
initial amount: NaN
is: CHEBI:17596
has only substance units: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
initial concentration: 1.0
name: Inosine
is: HMDB00195
is: SBO:0000247

metaM tymsf e
has only substance units: false
is: HMDB06409
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
type: Species
name: Tyramine O-sulfate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_9ca14d5f_7064_44a8_9d16_9d7dd1147467
has only substance units: false
is: P16442
boundary condition: true
is: SBO:0000252
is encoded by: hsa:28
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
name: ABO

MODEL1310110054
reaction: metaR BHBtm
reaction: metaR r0181
species: metaM gsn c
reaction: metaR ACCOAgt
reaction: metaR O2tp
species: metaM CE5116 x
reaction: metaR CYTDtm
reaction: metaR GLCter
reaction: metaR NDPK2n
reaction: metaR LEULEUPEPT1tc
species: metaM h2o l
species: metaM CE4872 m
reaction: metaR EX HC01104 LPAREN e RPAREN
reaction: metaR r0527
reaction: metaR r2312
reaction: metaR HGNTOR
reaction: metaR FAS180COA
species: metaM ach c
reaction: metaR ABUTt2r
species: metaM odecoa r
species: metaM 2docopencoa x
reaction: metaR RE3568C
species: metaM nadh x
species: metaM HC00822 e
species: metaM octe5coa x
species: metaM 5dhf e
reaction: metaR r1607
species: metaM spc hs e
reaction: metaR r1012
reaction: metaR FAOXC184C164x
reaction: metaR r2105
reaction: metaR CYTDK2m
reaction: metaR r1782
reaction: metaR FAOXC164m
species: metaM retinal cis 9 c
species: metaM HC00229 e
reaction: metaR r0642
reaction: metaR r0178
reaction: metaR RE2999M
reaction: metaR r2081
reaction: metaR XOL7AONEtr
reaction: metaR FAOXC180
species: metaM sphs1p r
reaction: metaR GCALDD
species: metaM core6 l
species: metaM C02528 c
reaction: metaR EX 4abut LPAREN e RPAREN
reaction: metaR r2371
reaction: metaR BILGLCURtr
reaction: metaR r0860
species: metaM h2o g
reaction: metaR DRPA
reaction: metaR r0720
reaction: metaR CBR2
species: metaM na1 e
reaction: metaR CYSALANaEx
species: metaM 3m4hpga c
reaction: metaR r0752
reaction: metaR MALSO3tm
reaction: metaR r0829
reaction: metaR CYTK5
reaction: metaR NACHEX1ly
species: metaM ksi deg36 l
reaction: metaR MTHFR3
reaction: metaR EX HC01609 LPAREN e RPAREN
species: metaM cs e deg6 l
species: metaM ksii core2 pre3 g
reaction: metaR NCNt
species: metaM amet m
species: metaM 4hexdtetcoa m
reaction: metaR CYTK1m
species: metaM CE4790 m
reaction: metaR TDPm
species: metaM cs e deg4 l
reaction: metaR r1384
species: metaM ksii core2 pre1 g
species: metaM galside hs l
species: metaM n2m2mn l
reaction: metaR LTA4H
reaction: metaR r2368

metaR ABTD
kinetic law: MODEL1310110054#
is: SBO:0000176
name: L-arabinitol 4-dehydrogenase
type: Reaction
fast: false
reactant: MODEL1310110054#
reversible: true
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
is described by: ECO:0000000

metaR r0821
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
modifier: MODEL1310110054#
reactant: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
fast: false

metaR RE2987X
reactant: MODEL1310110054#
name: RE2987
is: SBO:0000176
type: Reaction
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:10970790,PMID:7775433 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110054#

metaM h2o2 x
type: Species
is: HMDB03125
boundary condition: false
constant: false
is: CHEBI:16240
has only substance units: false
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: SBO:0000247
is: C00027
name: Hydrogen peroxide
initial amount: NaN

metaR r1660
modifier: MODEL1310110054#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110054#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_ee921217_ee51_4469_8412_0bad72c55a05
is encoded by: hsa:2582
is: Q38G75
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
has only substance units: false
name: GALE

http://identifiers.org/biomodels.db/MODEL1310110054#_8fe2e837_d6a9_41df_9ab3_6888e7015afc
is encoded by: hsa:94005
boundary condition: true
has only substance units: false
is encoded by: hsa:8733
is encoded by: hsa:10026
has part: Q8NBL9
is: SBO:0000297
is encoded by: hsa:128869
constant: false
has part: Q92643
has part: Q969N2
has part: Q9H490
initial amount: NaN
is encoded by: hsa:51604
initial concentration: NaN
name: PIGK:PIGU:PIGT:GPAA1:PIGS
has part: O43292
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_0613de9a_efa7_4834_be53_fe71d942a352
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: SLC16A2
constant: false
is encoded by: hsa:6567
is: P36021

metaM acgal l
name: N-acetyl-D-galactosamine
is: HMDB00212
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:28037
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_466a9965_5930_4ea9_91ef_892ad910918a
boundary condition: true
constant: false
initial concentration: NaN
is: Q5MY95
initial amount: NaN
is: SBO:0000252
name: ENTPD8
is encoded by: hsa:377841
has only substance units: false
type: Species

metaM gluside hs l
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:18368
boundary condition: false
initial concentration: 1.0
name: D-glucosyl-N-acylsphingosine
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_a35283cc_bbb1_4b2c_8491_e006886cec5c
name: AK2
is: P54819
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:204
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species

metaR SUCCt2m
fast: false
type: Reaction
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is described by: ECO:0000269
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: true
is: SBO:0000185
name: succinate transport, mitochondrial

metaR PSt3
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
name: phosphatidylserine transport
reversible: true
product: MODEL1310110054#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_3af52125_d941_4ee4_9c81_98cafadf0700
is: SBO:0000252
is encoded by: hsa:T83654
type: Species
name: _T83654_1_c
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM h2o r
type: Species
boundary condition: false
has only substance units: false
name: H2O
initial amount: NaN
is: C00001
is: CHEBI:15377
is: HMDB02111
initial concentration: 1.0
constant: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247

metaR r0822
is: SBO:0000185
kinetic law: MODEL1310110054#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110054#
fast: false
reversible: true
reactant: MODEL1310110054#
type: Reaction
is described by: ECO:0000000

metaR r0060
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.3.1.17 Confidence Level: 0 AUTHORS: PMID:4433562 NOTES:
name: L-serine ammonia-lyase Glycine, serine and threonine metabolism EC:4.3.1.17
product: MODEL1310110054#
type: Reaction
reversible: false
kinetic law: MODEL1310110054#
fast: false
is: SBO:0000176
is described by: ECO:0000000

metaR DOLPMT U
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.83
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
type: Reaction
reversible: false
product: MODEL1310110054#
name: Dolichyl-phosphate D-mannosyltransferase (uterus)

metaR PIter
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
type: Reaction
name: phosphate transport, endoplasmic reticulum
modifier: MODEL1310110054#
fast: false
product: MODEL1310110054#
reactant: MODEL1310110054#
reversible: true
is: SBO:0000185
is described by: ECO:0000212
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_dd94984e_4964_4733_b62f_3a4c5e05fe64
constant: false
type: Species
has only substance units: false
name: SLC7A8:SLC3A2
initial amount: NaN
has part: Q86U05
is encoded by: hsa:23428
initial concentration: NaN
boundary condition: true
is: SBO:0000297

metaM CE5119 m
constant: false
name: trans-3-cis-8-tetradecadienoyl-CoA
is: CHEBI:57923
boundary condition: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaM glyc m
has only substance units: false
is: CHEBI:17754
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00131
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: C00116
name: Glycerol

http://identifiers.org/biomodels.db/MODEL1310110054#_1f030a2f_8ecc_4d30_a5e5_f4792359412b
type: Species
initial amount: NaN
is: O15056
is encoded by: hsa:8871
is: SBO:0000252
has only substance units: false
name: SYNJ2
boundary condition: true
initial concentration: NaN
constant: false

metaR AKR1D
is described by: ECO:0000269
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.3
modifier: MODEL1310110054#
fast: false
reversible: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)

http://identifiers.org/biomodels.db/MODEL1310110054#_a4516427_e688_44a9_bd44_d956703a5797
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:11046
constant: false
name: SLC35D2
initial concentration: NaN
initial amount: NaN
is: Q76EJ3
is: SBO:0000252

metaR 5AOPtm
fast: false
is: SBO:0000185
is described by: ECO:0000134
product: MODEL1310110054#
type: Reaction
name: 5-Aminolevulinate mitochondrial transport
reactant: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10558864 NOTES:NCD. Delta-aminolevulinic acid is produced in mitochondria then converted to PBG in the cytoplasm. Could not find anything on the transporter itself.

metaR GLNCYSNaEx
name: L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)
reversible: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
kinetic law: MODEL1310110054#
is described by: ECO:0000269
type: Reaction
fast: false
modifier: MODEL1310110054#
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_3ff7fdfe_5cbc_41e1_929e_5ff18ced4f25
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: PI4KA
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:5297
is: B4DYG5

http://identifiers.org/biomodels.db/MODEL1310110054#_b5651de3_c22f_49b2_aab5_8fa05bb6a373
boundary condition: true
type: Species
initial concentration: NaN
name: SLC25A16
initial amount: NaN
has only substance units: false
is: P16260
is encoded by: hsa:8034
constant: false
is: SBO:0000252

metaM retinol cis 13 c
boundary condition: false
is: SBO:0000247
name: 13-cis-retinol
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13-
is: CHEBI:45479
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB06217
initial amount: NaN
constant: false

metaM ile L e
boundary condition: false
is: HMDB00172
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
initial amount: NaN
is: CHEBI:17191
constant: false
name: L-isoleucine
initial concentration: 1.0
type: Species

metaM melatn c
is: CHEBI:16796
notes: FORMULA: C13H16N2O2 CHARGE: 0 INCHI: InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C01598
boundary condition: false
name: melatonin
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB01389
type: Species
constant: false
has only substance units: false

metaM gluside hs g
constant: false
initial amount: NaN
name: D-glucosyl-N-acylsphingosine
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial concentration: 1.0
is: CHEBI:18368

http://identifiers.org/biomodels.db/MODEL1310110054#_9c276553_3859_4d3f_baa8_0f0d1427210b
name: GALNT7
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is: Q86SF2
boundary condition: true
is encoded by: hsa:51809
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_f19b27d9_3dee_40f5_8647_4415d03a674f
constant: false
is: P22234
is: SBO:0000252
is encoded by: hsa:10606
type: Species
initial concentration: NaN
boundary condition: true
name: PAICS
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_3a0d1760_4870_458d_ba55_3454a7f755f4
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: SOD1
is: P00441
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6647
constant: false
type: Species

metaR 2HBt2
type: Reaction
name: 2-hydroxybutyrate cotransport with proton
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110054#
is described by: ECO:0000269
modifier: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#

metaM ksi deg21 l
has only substance units: false
name: keratan sulfate I, degradation product 21
is: HMDB00143
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:12936
notes: FORMULA: C132H213N9O114S6 CHARGE: -6

metaM 4abut c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00112
notes: FORMULA: C4H9NO2 CHARGE: 0
constant: false
is: C00334
name: 4-Aminobutanoate
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:3628

metaR r1380
type: Reaction
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
reversible: true
is: SBO:0000176
reactant: MODEL1310110054#
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72

metaM h2o l
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
initial concentration: 1.0
is: HMDB02111
constant: false
initial amount: NaN
is: CHEBI:15377
type: Species
boundary condition: false
name: water

metaM trp L c
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: L-tryptophan
is: SBO:0000247
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: CHEBI:16828
is: HMDB00929

metaR 5ADTSTSTERONESULT
notes: GENE_ASSOCIATION: (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES:NJ
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.8.2.14
is: SBO:0000176
name: 5alpha-Dihydrotestosterone sulfotransferase
product: MODEL1310110054#
reactant: MODEL1310110054#
modifier: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
fast: false
reversible: false

metaR G14T2g
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110054#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
fast: false
is: SBO:0000176
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_a355fdd5_4c69_48d0_8d3d_080b86f2f32f
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:BE966236
name: _BE966236_1_c
initial amount: NaN
constant: false

metaM pi c
has only substance units: false
constant: false
is: HMDB00973
is: CHEBI:43474
type: Species
notes: FORMULA: HO4P CHARGE: -2
initial concentration: 1.0
name: hydrogenphosphate
is: C00009
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR NDP10ex
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.6
fast: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
type: Reaction
name: nucleoside-diphosphatase (IDP), extracellular
is described by: ECO:0000269
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
reactant: MODEL1310110054#

metaM 3hmbcoa m
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
initial concentration: 1.0
is: CHEBI:57312
constant: false
boundary condition: false
initial amount: NaN
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
type: Species
has only substance units: false
is: HMDB01356
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_2fe78e87_017d_4da3_aa0f_9a60aec55188
is: Q6IBC4
name: NDUFS6
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:4726
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_e9a1b4c1_833a_4f65_920f_3e82adac11da
has part: Q07326
name: PIGF:PIGO
has part: Q8TEQ8
boundary condition: true
is encoded by: hsa:84720
is: SBO:0000297
constant: false
is encoded by: hsa:5281
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_6080db84_b1ed_4c17_b9b1_424a28a3f328
initial amount: NaN
type: Species
boundary condition: true
name: _AI024818_1_c
initial concentration: NaN
constant: false
is encoded by: hsa:AI024818
is: SBO:0000252
has only substance units: false

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaM pheacgln c
is: SBO:0000247
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:58310
has only substance units: false
initial amount: NaN
is: HMDB06344
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110054#_6e0998cc_bd01_423d_b5b1_f640dbccca3d
is encoded by: hsa:57134
is: SBO:0000252
name: MAN1C1
type: Species
is: Q9NR34
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_d132b994_e8d3_4f21_8bbd_b030ffd2ba3a
has part: P50993
initial amount: NaN
is encoded by: hsa:23439
has only substance units: false
constant: false
is encoded by: hsa:477
boundary condition: true
initial concentration: NaN
name: ATP1B4:ATP1A2
has part: Q9UN42
is: SBO:0000297
type: Species

metaR RE1523M
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1523
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000176
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_f0f79812_c764_401c_909b_253422ddb6a2
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q01415
name: GALK2
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2585

metaM pac c
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00209
name: phenylacetate
is: CHEBI:18401
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
is: SBO:0000247

metaR NADPHtxu
type: Reaction
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
reversible: false
name: NADPH transporter, peroxisome
fast: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ free hydrogens NJ
is described by: ECO:0000000
is: SBO:0000185

metaM h2o m
is: HMDB02111
initial concentration: 1.0
is: CHEBI:15377
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: C00001
type: Species
name: H2O

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_7c318172_0d81_4fca_ad7d_18172daefe82
initial concentration: NaN
boundary condition: true
is encoded by: hsa:480
name: ATP1A4
is: SBO:0000252
is: Q13733
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaR FAOXC164C163x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)x
type: Reaction

metaM ile L c
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
is: HMDB00172
is: CHEBI:17191
constant: false
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
name: L-isoleucine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_de59033b_ef17_4c6a_9af6_cc9dec2dd773
boundary condition: true
constant: false
type: Species
initial concentration: NaN
name: ATP1A3:ATP1B2
has part: P14415
is: SBO:0000297
has only substance units: false
is encoded by: hsa:482
initial amount: NaN

metaR CRVNCtr
is: SBO:0000185
fast: false
product: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
name: fatty acid transport via diffusion
reversible: true
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110054#_da5f2afd_75be_4e5c_b1cc_3a51e786a9cb
is encoded by: hsa:2678
type: Species
name: GGT1
initial concentration: NaN
is: P19440
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR S6T6g
fast: false
modifier: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110054#
product: MODEL1310110054#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
reversible: false
is: SBO:0000176
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_367e9a2d_d190_4841_a474_670b861c6293
boundary condition: true
has part: O15254
has only substance units: false
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is: SBO:0000297
name: EHHADH:ACAA1:HSD17B4:ACOX3
is encoded by: hsa:8310

http://identifiers.org/biomodels.db/MODEL1310110054#_c25cad04_6456_477d_805e_21a78066b8fe
constant: false
has only substance units: false
type: Species
name: SULT1A1
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6817

metaM dopa c
is: CHEBI:59905
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00073
has only substance units: false
type: Species
name: dopaminium(1+)
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
initial amount: NaN

metaR Q10H2e
is described by: ECO:0000134
type: Reaction
product: MODEL1310110054#
reversible: true
reactant: MODEL1310110054#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
fast: false
name: transport of ubiquinol into lymph
kinetic law: MODEL1310110054#

metaR MCLACCYSR
is described by: ECO:0000000
product: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
is: SBO:0000176
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
name: 3-mercaptolactate:cysteine reductase
fast: false
type: Reaction

metaR PMEVKx
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.4.2
fast: false
product: MODEL1310110054#
reversible: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.4.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
type: Reaction
name: phosphomevalonate kinase
is described by: ECO:0000134
kinetic law: MODEL1310110054#
is: SBO:0000176

metaR RE1534M
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110054#
name: RE1534
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110054#
is described by: ECO:0000000
modifier: MODEL1310110054#
product: MODEL1310110054#
reversible: true

metaR CMPSAS
product: MODEL1310110054#
type: Reaction
reversible: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
name: CMP sialic acid synthase
is version of: http://identifiers.org/ec-code/2.7.7.43
fast: false
is: SBO:0000176
is described by: ECO:0000304
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_7e2e5363_5d36_4a6b_b322_6d46372fea16
is encoded by: hsa:8611
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: PPAP2A
is: G3XA95
boundary condition: true
constant: false

metaM h2o n
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:15377
type: Species
boundary condition: false
name: water
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_a5ac73d5_5b4e_4838_b400_843996dd01b2
is: Q8N0W3
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:197258
initial concentration: NaN
name: FUK
constant: false

metaM trp L e
initial amount: NaN
is: CHEBI:16828
initial concentration: 1.0
constant: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00929
name: L-tryptophan

metaM 4mop c
initial concentration: 1.0
is: HMDB00695
initial amount: NaN
constant: false
is: CHEBI:17865
boundary condition: false
name: 4-methyl-2-oxopentanoate
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233

metaM HC02205 c
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:28099
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
is: SBO:0000247
name: prostaglandin-b2
has only substance units: false
type: Species

metaM m2mpdol L c
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C1420H2328N20O320P20 CHARGE: -20
is: CHEBI:28049
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0

metaM pi e
is: HMDB00973
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
type: Species
is: C00009
name: hydrogenphosphate
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false

metaR r0714
is described by: ECO:0000000
reversible: false
fast: false
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000176
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction

metaR C3STDH1Pr
is described by: ECO:0000134
type: Reaction
name: C-3 sterol dehydrogenase (4-methylzymosterol)
is: SBO:0000176
product: MODEL1310110054#
reversible: false
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.1.1.170
fast: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
modifier: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_66250b22_3e1f_487b_8113_75d72d477284
initial concentration: NaN
constant: false
boundary condition: true
name: CLYBL
type: Species
is encoded by: hsa:171425
has only substance units: false
is: Q8N0X4
is: SBO:0000252
initial amount: NaN

metaR r1381
product: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#
fast: false
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
reactant: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_afdf0dc0_3723_47b6_86a5_120a75e5ead9
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: NDUFB1
is: SBO:0000252
is encoded by: hsa:4707
is: O75438
boundary condition: true

metaM HC01602 c
constant: false
name: 10-Formyltetrahydrofolate
is: CHEBI:57454
type: Species
is: SBO:0000247
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: C00234
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR GGH 6THFe
is: SBO:0000176
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
reversible: false
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (6THF), extracellular
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110054#

metaM dopa e
has only substance units: false
is: HMDB00073
initial concentration: 1.0
name: dopaminium(1+)
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: CHEBI:59905
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_952f75b5_064a_4db6_bd94_cff800837c43
is: Q16760
is encoded by: hsa:8527
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
name: DGKD
boundary condition: true

metaM xol7ah3 c
has only substance units: false
is: HMDB12455
name: 5beta-cholestane-3alpha,7alpha,26-triol
is: CHEBI:28540
type: Species
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_ae9ee948_91be_4e71_b62c_ec3f89648c69
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: A8K8P8
has only substance units: false
initial concentration: NaN
name: FUT8
is encoded by: hsa:2530

metaM gluside hs c
initial concentration: 1.0
is: CHEBI:18368
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
has only substance units: false
name: D-glucosyl-N-acylsphingosine
boundary condition: false

metaR FAOXC102m
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

metaR NDPK10
reactant: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110054#
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dIDP)
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000134
modifier: MODEL1310110054#

metaR ADK3m
reactant: MODEL1310110054#
is: SBO:0000176
type: Reaction
fast: false
reversible: true
is described by: ECO:0000269
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.4.10
name: adentylate kinase (GTP)
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
modifier: MODEL1310110054#

metaR PI4PP
name: phosphatidylinositol-4-phosphate 4-phosphatase
is: SBO:0000176
reactant: MODEL1310110054#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2425833 NOTES:NCD
reversible: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_1404b5b6_5c2d_4831_a203_b64027beae14
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:622
name: BDH1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_8b278631_b954_48d5_a106_0014b5fa8b02
is encoded by: hsa:251
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is: P10696
has only substance units: false
name: ALPPL2
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_78e344e6_5d74_42d9_9d56_45790c63e2ca
constant: false
has only substance units: false
initial concentration: NaN
name: CHST3
is: SBO:0000252
is: Q7LGC8
is encoded by: hsa:9469
boundary condition: true
initial amount: NaN
type: Species

metaM pi g
is: CHEBI:43474
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN
constant: false
name: hydrogenphosphate
type: Species
is: HMDB00973
boundary condition: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_metaR_GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEte
reactant: MODEL1310110054#
product: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
kinetic law: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: blood group intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110054#_8ceff444_1e69_4658_ac55_1ded309e23c3
has only substance units: false
type: Species
is: P36542
is encoded by: hsa:509
initial concentration: NaN
name: ATP5C1
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM glyc c
is: HMDB00131
initial concentration: 1.0
has only substance units: false
is: C00116
type: Species
is: CHEBI:17754
constant: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: Glycerol

metaR PAIL45P HStn
fast: false
kinetic law: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
product: MODEL1310110054#
reversible: true
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110054#_e0036e98_6c10_4500_8e70_b8af136528a1
has only substance units: false
is encoded by: hsa:26062
name: HYALP1
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true

metaR DURIPP
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110054#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.3
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
modifier: MODEL1310110054#
product: MODEL1310110054#
name: deoxyuridine phosphorylase

metaR C3STKR2r
is described by: ECO:0000134
reactant: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
name: C-3 sterol keto reductase (zymosterol)
is: SBO:0000176
reversible: false
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110054#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_f5e717b5_780f_430c_96be_710e159253c4
is: P51687
constant: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6821
name: SUOX
is: SBO:0000252

metaM 4abut e
initial amount: NaN
name: 4-Aminobutanoate
boundary condition: false
is: HMDB00112
is: C00334
is: CHEBI:3628
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110054#_b605534d_073e_46de_ba59_7e7639d6596d
constant: false
name: SLC6A7
is: Q99884
is encoded by: hsa:6534
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN

metaR r1156
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
product: MODEL1310110054#
type: Reaction
reversible: true
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
fast: false
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000176

metaM prpncoa m
is: CHEBI:57367
initial concentration: 1.0
is: HMDB02307
boundary condition: false
name: acryloyl-CoA(4-)
has only substance units: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
is: SBO:0000247

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaR VLCS2p
modifier: MODEL1310110054#
name: Very-long-chain-fatty-acid-CoA ligase
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: PMID:10479480 NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is: SBO:0000176
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
reversible: false
type: Reaction

metaM glyclt x
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
name: glycolate
is: CHEBI:29805
is: HMDB00115
constant: false
has only substance units: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160

metaM ksi pre5 g
is: SBO:0000247
boundary condition: false
is: CHEBI:28067
initial amount: NaN
notes: FORMULA: C101H164N7O75SX CHARGE: -2
constant: false
type: Species
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 5
initial concentration: 1.0

metaM kynate c
initial amount: NaN
is: CHEBI:58454
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00715
boundary condition: false
name: kynurenate
constant: false
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_245466de_4e9c_403c_8668_7a747cbff612
is: E7ET32
initial concentration: NaN
is encoded by: hsa:2592
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: GALT
boundary condition: true
constant: false

metaR HEX7
is version of: http://identifiers.org/ec-code/2.7.1.2
name: hexokinase (D-fructose:ATP)
reversible: false
type: Reaction
reactant: MODEL1310110054#
fast: false
product: MODEL1310110054#
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
is version of: http://identifiers.org/ec-code/2.7.1.1
is: SBO:0000176
is described by: ECO:0000304

metaR ACGAMtly
reactant: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110054#
name: N-acetyl-glucosamine lysosomal efflux

metaR RE3241R
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110054#
reversible: false
kinetic law: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110054#
name: RE3241

metaM dolglcp L r
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
constant: false
is: SBO:0000247
type: Species
is: CHEBI:15812
initial amount: NaN
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_metaR_GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEtg
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: blood group intracellular transport
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reversible: true
reactant: MODEL1310110054#

metaM glyc e
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17754
boundary condition: false
is: HMDB00131
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
has only substance units: false
name: Glycerol
is: C00116

metaR RE1845X
kinetic law: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
product: MODEL1310110054#
name: RE1845
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
reversible: true

metaR AG13T14g
reversible: false
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
is described by: ECO:0000000
product: MODEL1310110054#
is: SBO:0000176
modifier: MODEL1310110054#

metaM hs deg23 l
constant: false
has only substance units: false
is: HMDB02704
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C31H49NO29S CHARGE: -2
is: CHEBI:21338
type: Species
boundary condition: false
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: SBO:0000247

metaR DOLPMT1 Uer
product: MODEL1310110054#
reversible: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is version of: http://identifiers.org/ec-code/2.4.1.258
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
modifier: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#
is described by: ECO:0000000
reactant: MODEL1310110054#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_df064eae_17bd_4a00_9327_7330bfdcd660
boundary condition: true
type: Species
is: SBO:0000252
name: SDHD
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: O14521
is encoded by: hsa:6392

metaR DOLDPP Ler
is version of: http://identifiers.org/ec-code/3.6.1.43
modifier: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
product: MODEL1310110054#
name: Dolichyl-diphosphate phosphohydrolase, human (liver)
is: SBO:0000176
fast: false

metaM HC01459 x
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450
is: SBO:0000247
type: Species
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA
is: CHEBI:27458
boundary condition: false

metaM gluala e
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
is: HMDB06248
is: http://identifiers.org/pubchem.compound/6503
name: 5-L-Glutamyl-L-alanine
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
constant: false
is: C03740
initial amount: NaN
boundary condition: false

metaR r1375
is: SBO:0000185
reversible: false
name: Transport reaction
reactant: MODEL1310110054#
fast: false
type: Reaction
kinetic law: MODEL1310110054#
is described by: ECO:0000000
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:

metaR GLCNACPT U
type: Reaction
modifier: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.8.15
fast: false
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110054#
reactant: MODEL1310110054#
reversible: false
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (uterus)

metaR r2104
product: MODEL1310110054#
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110054#
fast: false
type: Reaction
modifier: MODEL1310110054#
reversible: true

metaR RE3270C
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:IT - fixed proton
type: Reaction
reactant: MODEL1310110054#
fast: false
product: MODEL1310110054#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
name: RE3270
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_ddfd33e6_3dbb_413b_9c93_44f8c8abe1d8
initial amount: NaN
is: Q02153
name: GUCY1B3
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:2983

metaR r1599
kinetic law: MODEL1310110054#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110054#
product: MODEL1310110054#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaM xylt c
name: xylitol
constant: false
boundary condition: false
is: HMDB02917
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:17151
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379

http://identifiers.org/biomodels.db/MODEL1310110054#_c824cbfd_c7db_498f_bf86_7d46ea01e7b9
initial concentration: NaN
is encoded by: hsa:LOC728997
is: SBO:0000252
type: Species
name: _LOC728997_1_c
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false

metaR r0707
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.168
reversible: true
product: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
type: Reaction
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate phosphohydrolase (alkaline optimum) Folate biosynthesis EC:3.1.3.1

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is: Q546Y9
has only substance units: false
boundary condition: true
name: AICDA
is encoded by: hsa:57379
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
initial concentration: NaN

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initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:219
constant: false
initial concentration: NaN
name: ALDH1B1
is: P30837

metaR r2103
type: Reaction
modifier: MODEL1310110054#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110054#
fast: false
is described by: ECO:0000000
product: MODEL1310110054#
is: SBO:0000185

metaM pro D e
constant: false
is: CHEBI:16313
type: Species
boundary condition: false
initial amount: NaN
name: D-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB03411

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is: O43678
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4695
has only substance units: false
is: SBO:0000252
name: NDUFA2
initial amount: NaN
constant: false
type: Species

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has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8394
constant: false
is: Q99755
is: SBO:0000252
name: PIP5K1A
type: Species
boundary condition: true

metaM inost e
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: myo-inositol
is: CHEBI:17268
is: HMDB00211
boundary condition: false
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137

metaR PRISTCOAtcx
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

metaM c12dccoa x
is: C14143
type: Species
is: SBO:0000247
name: dodecanedioylcoa
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
is: HMDB04047

metaM sebcoa x
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
name: sebacoylcoa
boundary condition: false
has only substance units: false

metaM h2o2 n
name: hydrogen peroxide
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: HMDB03125

metaR FAOXC221C201x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

metaM citr L e
is: SBO:0000247
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00904
is: CHEBI:16349
constant: false
name: citr_L[e]
has only substance units: false
boundary condition: false

metaR DIDPtn
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110054#
reactant: MODEL1310110054#
name: dIDP nuclear transport
kinetic law: MODEL1310110054#
fast: false
reversible: true
is: SBO:0000185

metaM m2gacpail hs r
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
boundary condition: false
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:16038
type: Species
initial concentration: 1.0

metaR r2102
reactant: MODEL1310110054#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
product: MODEL1310110054#
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM xol7ah2al c
is: CHEBI:27428
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
boundary condition: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
type: Species
constant: false
is: HMDB06894
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR EX gumgchol LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for guar gum-glycocholate complex
type: Reaction

metaM pi m
type: Species
boundary condition: false
is: C00009
is: CHEBI:43474
is: HMDB00973
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
is: SBO:0000247
constant: false
has only substance units: false

metaR H8TAer
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reversible: false
name: H8 transamidase, endoplasmic reticulum
modifier: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (10026.1) and (8733.1) and (128869.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
fast: false
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_9ff571d7_5fa0_42d2_b12a_a5979d1b24e9
name: _LOC647190_1_c
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:LOC647190
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN

metaR r1377
is: SBO:0000176
kinetic law: MODEL1310110054#
fast: false
type: Reaction
reactant: MODEL1310110054#
product: MODEL1310110054#
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_1be3f9e3_49e8_4528_88e2_adff822b9bbb
is encoded by: hsa:5150
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
name: PDE7A
initial concentration: NaN

metaM dece4coa x
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB02145
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
name: 4-decenoylcoa

metaR r1597
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110054#
is described by: ECO:0000000
reactant: MODEL1310110054#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110054#

metaR PA HStn
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: phosphatidate transport, nuclear
product: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110054#
fast: false
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_22bbe554_de1b_4150_b082_127e08042c17
boundary condition: true
type: Species
constant: false
is encoded by: hsa:2098
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P10768
name: ESD

metaM h2o2 m
is: C00027
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
name: Hydrogen peroxide
is: SBO:0000247
is: HMDB03125
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_01a0d8a4_69c6_487b_b1f0_355445004397
constant: false
initial amount: NaN
is: Q7LG56
name: RRM2B
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:50484

http://identifiers.org/biomodels.db/MODEL1310110054#_9c542071_b018_480c_89a2_a5f16a56e4d3
has only substance units: false
is: P09622
initial amount: NaN
type: Species
name: DLD
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1738
constant: false
initial concentration: NaN

metaR r2101
kinetic law: MODEL1310110054#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110054#
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110054#

metaM nm2masn g
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C42H70N3O30X CHARGE: 0
is: C05884
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_05ff7106_5e56_4151_a858_eb56aea575ea
is encoded by: hsa:221
is: SBO:0000252
constant: false
is: P43353
initial amount: NaN
initial concentration: NaN
name: ALDH3B1
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_37475461_d565_4ab7_a22c_2ec20baea381
is: SBO:0000252
constant: false
name: SLC25A13
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q9UJS0
initial concentration: NaN
is encoded by: hsa:10165
type: Species

metaM pi n
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:43474
is: HMDB00973
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
has only substance units: false
name: hydrogenphosphate
type: Species

metaM leuktrD4 e
is: HMDB03080
type: Species
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
name: Leukotriene D4
is: CHEBI:28666
has only substance units: false
boundary condition: false

metaM tmndnccoa m
has only substance units: false
name: timnodonyl coenzyme A
constant: false
is: SBO:0000247
is: HMDB06514
type: Species
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR r1378
kinetic law: MODEL1310110054#
is described by: ECO:0000000
fast: false
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
reversible: true
reactant: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
product: MODEL1310110054#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_944a3e1d_1a40_4499_bf9d_63c4eca01725
has only substance units: false
type: Species
is encoded by: hsa:5052
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
name: PRDX1

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type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: E9KL48
initial amount: NaN
name: GLUD1
constant: false
is encoded by: hsa:2746
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_ee73d7d0_3e0f_478d_891b_635e644b5b1d
type: Species
initial concentration: NaN
name: B3GALT5
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:10317

metaM duri n
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
constant: false
is: CHEBI:16450
is: SBO:0000247
is: HMDB00012
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
name: 2'-deoxyuridine
has only substance units: false

metaR FOLt2le
fast: false
reversible: true
product: MODEL1310110054#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: folate transport via anion exchange

metaR r1598
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM pro D c
is: SBO:0000247
is: HMDB03411
is: CHEBI:16313
boundary condition: false
type: Species
constant: false
initial amount: NaN
name: D-proline
has only substance units: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_12eb3178_5e44_4f06_94cd_19bc66759813
boundary condition: true
name: PPT1
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5538
is: Q6FGQ4
initial amount: NaN
constant: false

metaR MTHFR3
name: 5,10-methylenetetrahydrofolatereductase (NADPH)
type: Reaction
modifier: MODEL1310110054#
product: MODEL1310110054#
fast: false
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4524.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 2 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 350. NOTES:absorbed folate undergoes conversion to 5-methyl-THF within the enterocytes.
kinetic law: MODEL1310110054#
reversible: false
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.5.1.20

http://identifiers.org/biomodels.db/MODEL1310110054#_13c9a28d_7b8a_4eda_ba91_40b6f804c7ce
boundary condition: true
constant: false
is encoded by: hsa:43
initial amount: NaN
has only substance units: false
name: ACHE
type: Species
is: SBO:0000252
initial concentration: NaN
is: P22303

metaM ach e
is: HMDB00895
initial concentration: 1.0
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
name: acetylcholine
is: CHEBI:15355

metaR r2100
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110054#
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110054#_9200196c_e7c4_4e5b_878c_2aa2b2686410
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:AI697028
is: SBO:0000252
has only substance units: false
name: _AI697028_1_m
initial concentration: NaN
constant: false

metaR RE3347C
is: SBO:0000176
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
name: RE3347
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110054#
fast: false
type: Reaction
kinetic law: MODEL1310110054#

metaR HMBS
kinetic law: MODEL1310110054#
fast: false
is described by: ECO:0000254
modifier: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.5.1.61
reactant: MODEL1310110054#
type: Reaction
name: hydroxymethylbilane synthase
is: SBO:0000176
notes: GENE_ASSOCIATION: (3145.1) SUBSYSTEM: Heme synthesis EC Number: 4.3.1.8 Confidence Level: 2 AUTHORS: PMID:2875434 NOTES:
reversible: false

metaR ADCim
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110054#
reversible: false
name: Acetoacetate decarboxylation (irreversible), mitochondrial
product: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD

metaR GASNASEly
reversible: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110054#
fast: false
name: glycosylasparaginase, lysosomal
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.5.1.26
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#

metaM dolglcp U c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:15812
type: Species
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
boundary condition: false
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
is: SBO:0000247

metaR GLCAASE1ly
reversible: false
name: beta-glucuronidase, lysosomal
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
product: MODEL1310110054#
modifier: MODEL1310110054#
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.31
is described by: ECO:0000000

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaR r0917
is: SBO:0000185
type: Reaction
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
is described by: ECO:0000000
product: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR GALASE8ly
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
is: SBO:0000176
modifier: MODEL1310110054#
is described by: ECO:0000000
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
fast: false

metaM prpp e
has only substance units: false
is: HMDB00280
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
type: Species
boundary condition: false
constant: false
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
is: CHEBI:58017

http://identifiers.org/biomodels.db/MODEL1310110054#_e0e5b4c8_ca67_44c8_8d8a_9a447b55fad5
type: Species
is encoded by: hsa:AI656480
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
name: _AI656480_1_m

metaM cs e deg7 l
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15936
has only substance units: false
notes: FORMULA: C23H35O27S2 CHARGE: -3
constant: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_77fd49dd_2e0c_4131_b02c_4afbc405c5bc
is: SBO:0000252
name: GSTZ1
is encoded by: hsa:2954
is: A6NED0
constant: false
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR FUMSO4tm
type: Reaction
fast: false
product: MODEL1310110054#
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110054#
name: Fumarate:sulfate antiport, mitochondrial
reversible: true
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_0446d85e_532c_4f8a_956a_cbdaf4470403
has part: P21953
has part: B4DP47
is encoded by: hsa:593
name: DBT:DLD:BCKDHA:BCKDHB
has only substance units: false
boundary condition: true
is encoded by: hsa:594
constant: false
is: SBO:0000297
is encoded by: hsa:1629
type: Species
has part: P11182
initial concentration: NaN
initial amount: NaN

metaR EX HC00822 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chitobiose exchange
type: Reaction

metaM ach c
is: HMDB00895
initial concentration: 1.0
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
name: acetylcholine
is: SBO:0000247
constant: false
is: CHEBI:15355

metaM m6mpdol L r
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:37635
type: Species
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
notes: FORMULA: C1660H2728N20O520P20 CHARGE: -20
constant: false

metaR AHCYStr
kinetic law: MODEL1310110054#
reversible: true
product: MODEL1310110054#
name: S-Adenosyl-L-homocysteine intracellular diffusion
is described by: ECO:0000000
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
fast: false
type: Reaction
is: SBO:0000185

metaM 3pg m
boundary condition: false
initial amount: NaN
has only substance units: false
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
is: SBO:0000247
constant: false
is: HMDB00807
initial concentration: 1.0
is: CHEBI:58272
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
type: Species

metaM pheacgln e
initial amount: NaN
is: CHEBI:58310
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
type: Species
is: SBO:0000247
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
constant: false
is: HMDB06344
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR GLYSNAT5tc
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR r0706
reactant: MODEL1310110054#
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
reversible: false
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.3.99.10
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
fast: false
is described by: ECO:0000000
modifier: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#

metaM CE5118 m
constant: false
is: CHEBI:57923
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
type: Species
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_0507e3b6_5bcc_49a8_900c_6680d740004c
type: Species
has only substance units: false
initial amount: NaN
is: G5E960
is encoded by: hsa:5331
constant: false
name: PLCB3
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM hdd2coa x
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
name: (E)-hexadec-2-enoyl-CoA(4-)
is: HMDB03945
constant: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:61526

http://identifiers.org/biomodels.db/MODEL1310110054#_bdd738ce_6ed2_4e67_a4af_4b50d1b71592
has only substance units: false
is: E9PEI9
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4047
name: LSS
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_67e70069_112e_4982_a31d_babab77c420c
is: Q6FG42
constant: false
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:4701
initial amount: NaN
is: SBO:0000252
name: NDUFA7

http://identifiers.org/biomodels.db/MODEL1310110054#_58b7cf28_9cc5_48e6_af14_28c3d2ed6768
type: Species
is: Q96P26
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:93034
has only substance units: false
constant: false
name: NT5C1B
is: SBO:0000252

metaM pi r
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: C00009
constant: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
is: SBO:0000247
is: HMDB00973
is: CHEBI:43474
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_79c19bb6_03eb_4c33_8287_4c58868f38a5
is: P27707
constant: false
boundary condition: true
initial amount: NaN
name: DCK
is encoded by: hsa:1633
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaM estradiol r
is: CHEBI:16469
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: estradiol
initial concentration: 1.0
is: HMDB00151
boundary condition: false
type: Species
constant: false
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951

metaR ABO7g
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
reactant: MODEL1310110054#
modifier: MODEL1310110054#
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
kinetic law: MODEL1310110054#
is described by: ECO:0000269
is: SBO:0000176
fast: false
product: MODEL1310110054#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.37

http://identifiers.org/biomodels.db/MODEL1310110054#_10a26786_e00b_480c_b71e_00d1b03b39b2
initial amount: NaN
is: Q16678
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1545
constant: false
has only substance units: false
name: CYP1B1
initial concentration: NaN
type: Species

metaR FAOXC102x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)x
type: Reaction

metaR B3GNT33g
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reversible: false
fast: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_c5807f14_f901_4369_9a36_2adfcda9ab37
has only substance units: false
name: GALNS
initial concentration: NaN
is: P34059
constant: false
type: Species
is encoded by: hsa:2588
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_7e785037_33fa_44b2_97d9_cfdb264e4c8f
is: SBO:0000252
is: Q96I99
is encoded by: hsa:8801
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
name: SUCLG2

metaR r1446
product: MODEL1310110054#
reversible: false
name: EC:1.3.3.6
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#

metaR SIAT4Bg
product: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.4
is described by: ECO:0000269
reactant: MODEL1310110054#
reversible: false
kinetic law: MODEL1310110054#

metaR AHCYStd
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
fast: false
name: diffusion of S-Adenosyl-L-homocysteine
kinetic law: MODEL1310110054#
type: Reaction
is described by: ECO:0000134
product: MODEL1310110054#
reversible: true
reactant: MODEL1310110054#
is: SBO:0000185

metaM h2o2 c
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: C00027
initial amount: NaN
name: Hydrogen peroxide
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:16240
is: HMDB03125

http://identifiers.org/biomodels.db/MODEL1310110054#_ea366b0d_d55b_4724_b55b_78fa124580c3
is encoded by: hsa:56301
name: SLC7A10
has only substance units: false
constant: false
is: Q9NS82
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR r0813
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110054#
reactant: MODEL1310110054#
reversible: false
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:
kinetic law: MODEL1310110054#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.9
is described by: ECO:0000000
modifier: MODEL1310110054#

metaM dolglcp L c
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
is: SBO:0000247
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
has only substance units: false
initial amount: NaN
is: CHEBI:15812
boundary condition: false

metaM ksii core4 deg2 l
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
name: keratan sulfate II (core 4-linked), degradation product 2
is: CHEBI:12936
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
constant: false
is: HMDB00143
boundary condition: false

metaR r1591
product: MODEL1310110054#
kinetic law: MODEL1310110054#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR HSD3A1r
reactant: MODEL1310110054#
product: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
reversible: true
fast: false
type: Reaction
is described by: ECO:0000269
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is: SBO:0000176
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.1.1.225

metaR r0055
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.8
reactant: MODEL1310110054#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.7
modifier: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
reversible: true
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49

metaR RE2269E
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.21.39
type: Reaction
modifier: MODEL1310110054#
reversible: true
reactant: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176
name: RE2269
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:

metaR 3SALATAim
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
reactant: MODEL1310110054#
product: MODEL1310110054#
fast: false
is described by: ECO:0000304
reversible: false
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#

metaR SO4t4 2
is: SBO:0000185
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
modifier: MODEL1310110054#
type: Reaction
reversible: true
product: MODEL1310110054#
is described by: ECO:0000269
reactant: MODEL1310110054#
fast: false
name: sulfate transport via sodium symport
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_f80f41e5_6a13_4368_88e7_cfe645a689f1
is: P05091
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:217
boundary condition: true
name: ALDH2
is: SBO:0000252

metaR GLUPRT
kinetic law: MODEL1310110054#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.2.14
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
name: glutamine phosphoribosyldiphosphate amidotransferase
is: SBO:0000176
reactant: MODEL1310110054#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110054#
modifier: MODEL1310110054#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_5768552e_a9dd_4ad5_a8bf_7e0262b4ec62
initial amount: NaN
boundary condition: true
is encoded by: hsa:641372
constant: false
name: ACOT6
is: Q3I5F7
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN

metaM fpram c
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
type: Species
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
constant: false
is: C04640
is: HMDB06211
boundary condition: false
has only substance units: false
is: CHEBI:58478
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM udpacgal c
name: UDP-N-acetyl-D-galactosamine(2-)
type: Species
has only substance units: false
is: HMDB00304
is: SBO:0000247
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial concentration: 1.0
is: CHEBI:57847
constant: false
initial amount: NaN
boundary condition: false

metaM frdp x
initial concentration: 1.0
has only substance units: false
is: HMDB00961
name: farnesyl pyrophosphate(3-)
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: CHEBI:175763
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448

metaR H2Otm
reversible: true
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
fast: false
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
name: H2O transport, mitochondrial
modifier: MODEL1310110054#
product: MODEL1310110054#
type: Reaction

metaR FAOXC161C141x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C16:1-->C14:1)x
type: Reaction

metaR r1592
type: Reaction
is described by: ECO:0000000
product: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_945ea6db_6b5b_4750_8930_2378d86dee58
name: SPHK2
initial concentration: NaN
is: Q9NRA0
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:56848
type: Species
constant: false
boundary condition: true

metaM but e
is: CHEBI:17968
constant: false
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
initial concentration: 1.0
is: HMDB00039
name: butyrate
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_1704ecf8_5ff5_4708_8fed_05c234e85750
initial concentration: NaN
is: Q8NEM3
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:9194
type: Species
name: SLC16A7
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_4c65b8af_ed73_4c3a_873f_53087ba39ba0
boundary condition: true
initial concentration: NaN
is: Q9UKM7
constant: false
type: Species
is encoded by: hsa:11253
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: MAN1B1

http://identifiers.org/biomodels.db/MODEL1310110054#_18d6d7e5_a107_4355_9288_ab829e966657
initial concentration: NaN
is: P27338
name: MAOB
constant: false
boundary condition: true
is encoded by: hsa:4129
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252

metaR r0913
product: MODEL1310110054#
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#

metaR r0812
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185
fast: false
modifier: MODEL1310110054#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
type: Reaction
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
reactant: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.3.1.41
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_13312201_f3a5_4540_b8c6_6e4bfc81f191
is: P17568
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
name: NDUFB7
type: Species
is encoded by: hsa:4713
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_85bfdc60_aeef_484e_ac8c_264f95615d0e
is: SBO:0000252
is encoded by: hsa:6510
is: Q15758
constant: false
name: SLC1A5
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true

metaM h2o2 e
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
initial amount: NaN
name: hydrogen peroxide
is: CHEBI:16240
type: Species
is: HMDB03125
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_2145abbc_d014_4ed8_9a9e_541061646723
has part: B4DY56
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
type: Species
is encoded by: hsa:498
initial concentration: NaN
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110054#_464da6ca_7255_49c1_9bf1_927947819896
has only substance units: false
name: LDHA
constant: false
is: SBO:0000252
initial concentration: NaN
is: P00338
type: Species
is encoded by: hsa:3939
boundary condition: true
initial amount: NaN

metaR H2Otn
product: MODEL1310110054#
name: H2O transport, nuclear
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
fast: false
reactant: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#

metaM CE5132 c
type: Species
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57923
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
constant: false
has only substance units: false

metaM xoldiolone c
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
is: CHEBI:28477
is: SBO:0000247
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
type: Species
is: HMDB02197

http://identifiers.org/biomodels.db/MODEL1310110054#_a1f27f72_f549_4db1_b985_4a2cfef4c51a
boundary condition: true
is: SBO:0000252
type: Species
is: Q8TBG4
initial amount: NaN
name: AGXT2L1
initial concentration: NaN
constant: false
is encoded by: hsa:64850
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_6d4fdf45_5ccd_4b83_a158_7c3a6578fe63
constant: false
is: Q53HM1
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:54963
initial amount: NaN
name: UCKL1

metaR r2109
type: Reaction
modifier: MODEL1310110054#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110054#
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110054#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_f76c914f_bbd7_426a_98e0_349c73657e08
is: B2R6S5
boundary condition: true
is: SBO:0000252
is encoded by: hsa:51727
has only substance units: false
constant: false
initial concentration: NaN
name: CMPK1
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_e12341b8_1911_4e2b_af56_3c7867f96178
name: HAO2
is: Q9NYQ3
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:51179
initial amount: NaN
boundary condition: true

metaR HMGCOARc
fast: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.1.1.34
is described by: ECO:0000134
type: Reaction
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
reversible: false

metaM gal14acglcgalgluside hs g
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
type: Species
is: CHEBI:17103
initial amount: NaN
is: SBO:0000247
name: Lactoneotetraosylceramide

http://identifiers.org/biomodels.db/MODEL1310110054#_f8d0b0ff_e90b_4431_8ef8_5d715499b77f
is: SBO:0000252
initial amount: NaN
name: ALDH2
is encoded by: hsa:217
type: Species
boundary condition: true
has only substance units: false
is: P05091
constant: false
initial concentration: NaN

metaR MAGt
name: monoacylglycerol 2 transport
is: SBO:0000185
fast: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:10344773 NOTES:
kinetic law: MODEL1310110054#
reversible: true
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110054#

metaM citr L m
has only substance units: false
name: L-citrulline
initial amount: NaN
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
type: Species
is: HMDB00904
is: SBO:0000247
constant: false
is: CHEBI:16349
initial concentration: 1.0
boundary condition: false

metaM dhlam m
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
name: dihydrolipoamide
is: HMDB00985
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:17694
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579

metaR r1590
reactant: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110054#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185

metaM prpp c
initial amount: NaN
initial concentration: 1.0
is: HMDB00280
type: Species
constant: false
is: C00119
boundary condition: false
is: CHEBI:58017
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: SBO:0000247
name: 5-Phospho-alpha-D-ribose 1-diphosphate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_e353e37d_f79c_4fa9_b84a_96ff5a52bfd9
initial amount: NaN
type: Species
is: SBO:0000252
name: NAGLU
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:4669
initial concentration: NaN
is: P54802

http://identifiers.org/biomodels.db/MODEL1310110054#_97838b97_ea68_4a9a_9f25_6753f596b3d6
constant: false
is: Q86WU2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
name: LDHD
boundary condition: true
is encoded by: hsa:197257

metaM ach n
initial amount: NaN
has only substance units: false
is: HMDB00895
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: CHEBI:15355
name: acetylcholine
constant: false
initial concentration: 1.0

metaR GMPtg
product: MODEL1310110054#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
reversible: true
name: GMP transport (Golgi)
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#

metaR OCOAT1m
is version of: http://identifiers.org/ec-code/2.8.3.5
fast: false
reversible: true
notes: GENE_ASSOCIATION: (5019.1) or (64064.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.8.3.5 Confidence Level: 4 AUTHORS: PMID:10964512,PMID:11756565 NOTES:TDV
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
name: 3-oxoacid CoA-transferase
product: MODEL1310110054#
modifier: MODEL1310110054#

metaR r0915
type: Reaction
product: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
reactant: MODEL1310110054#
fast: false

metaR THP2Ctp
is: SBO:0000185
kinetic law: MODEL1310110054#
is described by: ECO:0000000
product: MODEL1310110054#
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
type: Reaction
fast: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
reversible: true

metaM aps c
is: HMDB01003
constant: false
is: SBO:0000247
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
name: 5'-adenylyl sulfate(2-)
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:58243
boundary condition: false
has only substance units: false

metaR r1668
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110054#
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
name: Y+LAT2 Utilized transport
reversible: true
is described by: ECO:0000000

metaR PROSTGE1t
product: MODEL1310110054#
modifier: MODEL1310110054#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
fast: false
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
name: prostaglandin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reversible: true

metaM 4hglusa m
boundary condition: false
is: HMDB06556
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:27809
name: L-4-hydroxyglutamic semialdehyde
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938

metaM k c
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
initial concentration: 1.0
has only substance units: false
is: C00238
name: potassium
constant: false
initial amount: NaN
is: HMDB00586
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:29103

metaR H2Otp
kinetic law: MODEL1310110054#
fast: false
is: SBO:0000185
name: H2O transport, peroxisomal
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110054#_160ff7e8_ff53_43c3_bf78_da4ca226f10f
boundary condition: true
constant: false
is encoded by: hsa:3030
type: Species
is: E9KL44
initial concentration: NaN
name: HADHA
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_d20c8363_4806_4365_8d09_e474ee4f260c
has only substance units: false
name: DBT
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:1629
is: P11182

metaR r2108
kinetic law: MODEL1310110054#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110054#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110054#

metaM duri e
constant: false
is: HMDB00012
boundary condition: false
is: CHEBI:16450
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: C00526
has only substance units: false
type: Species
name: Deoxyuridine

metaR r0603
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
kinetic law: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
modifier: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.3.1.12

metaM ksii core4 l
type: Species
constant: false
initial concentration: 1.0
is: HMDB01014
is: SBO:0000247
name: keratan sulfate II (core 4-linked)
boundary condition: false
initial amount: NaN
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
has only substance units: false
is: CHEBI:57255

metaR XOL7AH2tm
reactant: MODEL1310110054#
product: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000

metaR FAOXC225C204x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)x
type: Reaction

metaR r0817
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.41
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110054#
modifier: MODEL1310110054#
reactant: MODEL1310110054#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2

http://identifiers.org/biomodels.db/MODEL1310110054#_b1751847_903f_4a8d_bbdf_e2b24c208a3b
is: Q15392
constant: false
is encoded by: hsa:1718
has only substance units: false
name: DHCR24
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species

metaR r1595
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
reactant: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110054#
product: MODEL1310110054#
fast: false

metaR r1669
reactant: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110054#
name: Y+LAT2 Utilized transport
product: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: true
fast: false
type: Reaction
is: SBO:0000185

metaR r1443
fast: false
name: EC:1.3.3.6
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
kinetic law: MODEL1310110054#
is: SBO:0000176
product: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
reversible: false

metaM udpacgal g
initial concentration: 1.0
has only substance units: false
name: UDP-N-acetyl-D-galactosamine(2-)
type: Species
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: HMDB00304
initial amount: NaN
boundary condition: false
is: CHEBI:57847
constant: false
is: SBO:0000247

metaR NAHCO3 HCLt
reactant: MODEL1310110054#
name: bicarbonate transport (HCl/NaHCO3 exchange)
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
is: SBO:0000185
product: MODEL1310110054#
reversible: true
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_7d292a09_a2ff_4ff2_8668_0467199fe451
name: DPAGT1
initial amount: NaN
type: Species
is encoded by: hsa:1798
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false

metaM h2o x
is: SBO:0000247
boundary condition: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
is: HMDB02111
is: C00001
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:15377
type: Species
name: H2O

metaR NH4tp
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
product: MODEL1310110054#
is: SBO:0000185
name: ammonia peroxisomal transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM leuktrD4 c
initial amount: NaN
constant: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: HMDB03080
is: CHEBI:28666
has only substance units: false
is: SBO:0000247
name: Leukotriene D4
initial concentration: 1.0
type: Species
boundary condition: false

metaR r2521
type: Reaction
name: Utilized transport
kinetic law: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
reversible: true
product: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
fast: false

metaR r2107
modifier: MODEL1310110054#
product: MODEL1310110054#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
fast: false
reversible: true
is: SBO:0000185
type: Reaction

metaM ksi pre8 g
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
name: keratan sulfate I biosynthesis, precursor 8
is: CHEBI:28067

metaR PHEMEt
fast: false
kinetic law: MODEL1310110054#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110054#
name: heme transport
modifier: MODEL1310110054#
reversible: false
is: SBO:0000185
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD

metaM pi x
is: SBO:0000247
is: HMDB00973
boundary condition: false
name: hydrogenphosphate
constant: false
type: Species
initial amount: NaN
is: CHEBI:43474
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false

metaR r1596
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_87e10a9f_3757_42ba_b7c2_fcd56c1b243c
name: PANK2
constant: false
boundary condition: true
is encoded by: hsa:80025
type: Species
is: SBO:0000252
initial amount: NaN
is: Q6P1K9
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_a6b51c50_0846_4310_a4f9_fa4fa58136f6
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q9GZR5
initial amount: NaN
name: ELOVL4
is encoded by: hsa:6785

metaR r1666
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
name: Y+LAT2 Utilized transport
reversible: true
is: SBO:0000185
reactant: MODEL1310110054#
fast: false
product: MODEL1310110054#
type: Reaction

metaR HSD3B11
is version of: http://identifiers.org/ec-code/1.1.1.145
is: SBO:0000176
fast: false
reactant: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
reversible: false
modifier: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (3283.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:16023337 NOTES:progesterone prduction measured after the incubation of human granulosa cells with pregnenolone
is described by: ECO:0000134
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I

metaM k e
is: HMDB00586
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: CHEBI:29103
name: potassium
is: C00238
constant: false
has only substance units: false

metaM duri c
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
has only substance units: false
is: SBO:0000247
is: C00526
type: Species
is: CHEBI:16450
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: Deoxyuridine
is: HMDB00012

metaM m8mpdol U r
is: CHEBI:59093
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C1725H2840N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1
type: Species
has only substance units: false
boundary condition: false

metaR r2106
modifier: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110054#
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110054#

metaM CE2433 m
is: SBO:0000247
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
initial amount: NaN
initial concentration: 1.0
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
constant: false
boundary condition: false
type: Species
is: CHEBI:57795
has only substance units: false

metaR r1593
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110054#
fast: false

metaR G14T11g
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110054#
kinetic law: MODEL1310110054#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
modifier: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38

http://identifiers.org/biomodels.db/MODEL1310110054#_6ca8a7f5_40d6_4046_ba95_05b9f5cb97f7
is: SBO:0000252
name: VNN1
is encoded by: hsa:8876
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: O95497

metaR r0819
modifier: MODEL1310110054#
is: SBO:0000185
kinetic law: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
fast: false
reactant: MODEL1310110054#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110054#

metaR RE2998M
reactant: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110054#
reversible: false
name: RE2998
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_a873bcd6_8ae9_4a9e_a54b_3157ab25c20e
type: Species
is: O75038
initial amount: NaN
is encoded by: hsa:9651
name: PLCH2
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR r1667
is: SBO:0000185
kinetic law: MODEL1310110054#
name: Y+LAT2 Utilized transport
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110054#

metaR URIt5le
kinetic law: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110054#
name: uridine transport in via sodium symport (1:2)
reversible: false
is described by: ECO:0000134

metaM cs a deg4 l
constant: false
is: CHEBI:16953
has only substance units: false
is: HMDB00812
boundary condition: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C31H49NO29S CHARGE: -2

metaM inost c
is: CHEBI:17268
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
name: myo-inositol
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
constant: false
type: Species
is: HMDB00211
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_815750b3_4e9f_4d06_852f_775fd3b1828a
initial amount: NaN
boundary condition: true
is encoded by: hsa:7296
has only substance units: false
name: TXNRD1
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false

metaR NH4tn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
kinetic law: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
is: SBO:0000185
name: ammonia nuclear transport
reversible: true

metaR r2105
is: SBO:0000185
type: Reaction
reversible: true
modifier: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110054#
is described by: ECO:0000000
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110054#_42b7d3b7_3d22_4a49_9184_e8c65731f93c
name: AFMID
initial amount: NaN
constant: false
is: Q63HM1
initial concentration: NaN
type: Species
is encoded by: hsa:125061
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM frdp r
type: Species
initial amount: NaN
constant: false
is: CHEBI:175763
is: HMDB00961
is: C00448
name: Farnesyl diphosphate
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaR SUCD1m
fast: false
name: succinate dehydrogenase
reactant: MODEL1310110054#
type: Reaction
reversible: true
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.3.5.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
is described by: ECO:0000134
product: MODEL1310110054#
kinetic law: MODEL1310110054#

metaR EX oagd3 hs LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-O-Acetylated GD3 (homo sapiens) exchange
type: Reaction

metaR r0911
type: Reaction
is: SBO:0000185
name: Facilitated diffusion
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110054#
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_16bc4cba_9166_46dc_bf12_b532eab8b37d
is: SBO:0000252
initial amount: NaN
is: O43677
constant: false
name: NDUFC1
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4717
type: Species

metaR r0818
product: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
reversible: false
kinetic law: MODEL1310110054#
is: SBO:0000185
is described by: ECO:0000000
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
fast: false

metaR r1594
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#
reversible: true

metaM but c
initial concentration: 1.0
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
type: Species
is: CHEBI:17968
constant: false
name: butyrate
is: SBO:0000247
boundary condition: false
is: HMDB00039
has only substance units: false
initial amount: NaN

metaR ALR2
is version of: http://identifiers.org/ec-code/1.1.1.21
is: SBO:0000176
reversible: false
name: aldose reductase (methylglyoxal)
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is described by: ECO:0000269
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.1.1.2
fast: false

metaM dtmp e
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: CHEBI:26999
type: Species
initial concentration: 1.0
has only substance units: false
name: dTMP(2-)
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB01227

http://identifiers.org/biomodels.db/MODEL1310110054#_b2d1d498_8dd4_47bf_b7fb_83f2132b034d
initial amount: NaN
has only substance units: false
is encoded by: hsa:6487
name: ST3GAL3
is: SBO:0000252
constant: false
type: Species
is: Q11203
boundary condition: true
initial concentration: NaN

metaR r2519
fast: false
is described by: ECO:0000000
product: MODEL1310110054#
type: Reaction
reversible: true
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
is: SBO:0000185
reactant: MODEL1310110054#
name: Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110054#_f79fad3a_06a0_49ae_9886_b06cb475e480
has only substance units: false
initial amount: NaN
is encoded by: hsa:641649
initial concentration: NaN
boundary condition: true
is: C9JZ62
name: TMEM91
constant: false
type: Species
is: SBO:0000252

metaR r1671
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#
name: Y+LAT2 Utilized transport

metaM ksi pre15 g
is: SBO:0000247
initial concentration: 1.0
is: HMDB00175
is: C00130
initial amount: NaN
is: CHEBI:58053
has only substance units: false
type: Species
name: keratan sulfate I biosynthesis, precursor 15
constant: false
boundary condition: false
notes: FORMULA: C149H240N10O119S4X CHARGE: -5

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaM tdchola e
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
name: taurochenodeoxycholate
is: CHEBI:9407
is: HMDB00951
boundary condition: false
has only substance units: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_30885141_1360_4f9a_ac68_c0a3891493b4
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:279
is: SBO:0000252
name: AMY2A
is: P04746
initial concentration: NaN

metaR HSAT3ly
name: heparan-glucosaminide N-acetyltransferase, lysosomal
type: Reaction
reactant: MODEL1310110054#
reversible: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
fast: false
kinetic law: MODEL1310110054#
is: SBO:0000185
is described by: ECO:0000000

metaR MI14P4P
is described by: ECO:0000000
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110054#
type: Reaction
fast: false
name: inositol-1,4-bisphosphate 4-phosphatase
kinetic law: MODEL1310110054#
reversible: false

metaR CO2ter
reversible: true
product: MODEL1310110054#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
type: Reaction
name: CO2 endoplasmic reticular transport via diffusion

metaR r0834
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: true
product: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.16
reactant: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110054#_f53089db_00ab_4037_98ec_a1247194510a
has only substance units: false
name: SLC40A1
boundary condition: true
constant: false
type: Species
is encoded by: hsa:30061
is: SBO:0000252
initial amount: NaN
is: Q9NP59
initial concentration: NaN

metaR r1014
is: SBO:0000185
product: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
reversible: false
type: Reaction
fast: false
name: Postulated transport reaction

metaM arachcoa c
type: Species
constant: false
initial amount: NaN
name: arachidyl coenzyme A
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: SBO:0000247
is: CHEBI:15527
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB04258

http://identifiers.org/biomodels.db/MODEL1310110054#_8ee29032_0342_4c4c_81d7_46ca596ccc4a
is encoded by: hsa:170712
is encoded by: hsa:1346
constant: false
is encoded by: hsa:4514
has part: P14854
is encoded by: hsa:125965
is encoded by: hsa:84701
has part: Q8TF08
has part: Q02221
is encoded by: hsa:9167
has only substance units: false
is encoded by: hsa:4512
type: Species
is encoded by: hsa:1351
is encoded by: hsa:9377
is encoded by: hsa:1327
has part: Q7GXY8
is encoded by: hsa:1337
has part: Q96KJ9
is encoded by: hsa:1339
has part: Q6FGA0
initial concentration: NaN
is encoded by: hsa:1349
has part: P24310
initial amount: NaN
has part: Q6YFQ2
is encoded by: hsa:341947
has part: Q7Z4L0
is encoded by: hsa:1340
has part: P15954
has part: H0UI06
is encoded by: hsa:1345
has part: P00414
is: SBO:0000297
has part: Q7GXZ8
is encoded by: hsa:4513
has part: P12074
has part: P13073
has part: Q53YB7
has part: P20674
boundary condition: true
has part: P24311
has part: P09669
has part: Q53XN1
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is encoded by: hsa:1329
is encoded by: hsa:1347
is encoded by: hsa:1350

metaM ksii core2 pre1 g
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:28067
type: Species
name: keratan sulfate II biosynthesis, precursor 1
notes: FORMULA: C33H53N3O23X CHARGE: -1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_ef3c93a5_2c11_48ec_b378_b39dd0ff387b
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:LOC727762
is: SBO:0000252
name: _LOC727762_1_m
type: Species
initial amount: NaN
constant: false

metaM HC02203 e
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:27820
type: Species
name: prostaglandin-a2
constant: false

metaM bilirub r
is: SBO:0000247
boundary condition: false
name: bilirubin(2-)
has only substance units: false
type: Species
is: CHEBI:57977
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00054

metaM q10h2 m
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6504740
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB13111
name: Ubiquinol-10

http://identifiers.org/biomodels.db/MODEL1310110054#_555e7cdb_6757_4d0c_850c_7c46fd96fabf
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is: P15121
has only substance units: false
is encoded by: hsa:231
initial amount: NaN
name: AKR1B1
initial concentration: NaN

metaR r0835
modifier: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#
is: SBO:0000185
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.16
product: MODEL1310110054#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is described by: ECO:0000000
type: Reaction

metaR r1670
kinetic law: MODEL1310110054#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110054#
modifier: MODEL1310110054#
reversible: true
product: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185

metaM adp x
is: CHEBI:456216
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
has only substance units: false
is: HMDB01341
name: ADP(3-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_870dcb4b_7941_4915_adef_3c15cf51bd43
is encoded by: hsa:1374
is: Q8WZ48
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
name: CPT1A

metaR DHCRD1
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110054#
reversible: false
is: SBO:0000176
reactant: MODEL1310110054#
name: dihydroceramide desaturase
fast: false
product: MODEL1310110054#
is described by: ECO:0000269

metaR PRAGSr
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110054#
modifier: MODEL1310110054#
fast: false
name: phosphoribosylglycinamide synthase
is version of: http://identifiers.org/ec-code/2.1.2.2
kinetic law: MODEL1310110054#
reversible: true
is: SBO:0000176
type: Reaction
product: MODEL1310110054#
is described by: ECO:0000269

metaR TYMSULT
modifier: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.1
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
product: MODEL1310110054#
reversible: false
name: Tyramine Sulfotransferase
reactant: MODEL1310110054#

metaM hedepecoa m
has only substance units: false
type: Species
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB02288
is: SBO:0000247
boundary condition: false
name: 2,4,7,10,13-hexadecapentenoylcoa

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_221afe04_5580_404c_8307_0f1761fbf350
has only substance units: false
is encoded by: hsa:23530
initial amount: NaN
initial concentration: NaN
name: NNT
constant: false
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_e494d881_242e_4fb1_bcd2_3c509ee6c712
has only substance units: false
name: GCAT
type: Species
boundary condition: true
is: E2QC23
initial amount: NaN
is encoded by: hsa:23464
is: SBO:0000252
constant: false
initial concentration: NaN

metaR r1673
name: Y+LAT2 Utilized transport
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
product: MODEL1310110054#

metaR FAOXC184C164x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)x
type: Reaction

metaM tmndnccoa c
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB06514
boundary condition: false
initial amount: NaN
name: timnodonyl coenzyme A
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_88d47a2f_dc68_436c_b2eb_d5d5495ffc61
boundary condition: true
is encoded by: hsa:23761
initial concentration: NaN
constant: false
has only substance units: false
name: PISD
initial amount: NaN
is: SBO:0000252
is: Q9UG56
type: Species

metaR RE1796M
type: Reaction
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.145
kinetic law: MODEL1310110054#
reversible: true
is: SBO:0000176
fast: false
product: MODEL1310110054#
name: RE1796
reactant: MODEL1310110054#

metaR r1013
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
reversible: false
kinetic law: MODEL1310110054#
fast: false
product: MODEL1310110054#
is: SBO:0000185
type: Reaction
name: Transport reaction
reactant: MODEL1310110054#

metaM hs deg15 l
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
initial amount: NaN
has only substance units: false
is: HMDB00127
name: heparan sulfate, degradation product 15
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:15748
is: SBO:0000247

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaR ALR3
product: MODEL1310110054#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21
type: Reaction
name: aldose reductase (acetol)
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
modifier: MODEL1310110054#

metaM HC02203 c
initial concentration: 1.0
name: prostaglandin-a2
is: CHEBI:27820
type: Species
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_e61c87bb_f1fd_49b5_95ce_517007b623f5
boundary condition: true
is: A0S0A7
name: NOS3
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:4846
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_f4972a6c_4f8b_4fe4_ac92_262b35744f84
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5151
has only substance units: false
initial amount: NaN
name: PDE8A
type: Species
is: O60658

metaM amet m
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: HMDB01185
constant: false
is: C00019
boundary condition: false
is: CHEBI:15414
name: S-Adenosyl-L-methionine
initial concentration: 1.0

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaM dtmp c
constant: false
is: HMDB01227
has only substance units: false
is: C00364
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:26999
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
name: dTMP

http://identifiers.org/biomodels.db/MODEL1310110054#_de1a4c46_1de1_41f0_8e5f_bc20f9c03397
type: Species
name: PCBD1
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5092
constant: false
initial concentration: NaN
is: P61457

metaR r1012
reversible: false
kinetic law: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
fast: false
product: MODEL1310110054#
is: SBO:0000185
is described by: ECO:0000000
name: Postulated transport reaction
reactant: MODEL1310110054#

metaM prostgf2 e
boundary condition: false
initial amount: NaN
name: prostaglandin F2alpha(1-)
constant: false
initial concentration: 1.0
type: Species
is: HMDB01139
is: CHEBI:57404
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_e492bd0a_2bf2_4dac_8bed_774ccdf2de41
is: O14735
initial amount: NaN
is: SBO:0000252
name: CDIPT
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:10423
constant: false
initial concentration: NaN

metaM ala L e
has only substance units: false
is: CHEBI:16977
initial concentration: 1.0
is: SBO:0000247
is: HMDB00161
initial amount: NaN
constant: false
name: L-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_24f7791e_d59b_4d65_88df_4fc8291f9203
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P15954
type: Species
constant: false
name: COX7C
is encoded by: hsa:1350

metaM CE5868 e
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:27485
is: SBO:0000247
name: N-acetyl-seryl-aspartate
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H12N2O7 CHARGE: -2 INCHI: InChI=1/C9H14N2O7/c1-4(13)10-6(3-12)8(16)11-5(9(17)18)2-7(14)15/h5-6,12H,2-3H2,1H3,(H,10,13)(H,11,16)(H,14,15)(H,17,18)/p-2/t5-,6+/m1/s1 EHMN_ABBREVIATION: CE5868
is: HMDB02710

http://identifiers.org/biomodels.db/MODEL1310110054#_a5422594_262d_45a4_af51_cac0f69d0335
name: _BE042354_1_m
initial concentration: NaN
has only substance units: false
is encoded by: hsa:BE042354
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial amount: NaN

metaR O2Stx
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
kinetic law: MODEL1310110054#
fast: false
is: SBO:0000185
product: MODEL1310110054#
reversible: true
reactant: MODEL1310110054#
name: superoxide anion transport via diffusion (peroxisome)

metaR FAOXC123x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)x
type: Reaction

metaM 13dampp c
has only substance units: false
name: trimethylenediaminium
constant: false
initial amount: NaN
is: HMDB00002
initial concentration: 1.0
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
is: SBO:0000247
boundary condition: false
is: CHEBI:57484
type: Species

metaM ksi deg1 l
has only substance units: false
constant: false
type: Species
name: keratan sulfate I, degradation product 1
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
initial amount: NaN
boundary condition: false
is: CHEBI:18287
is: SBO:0000247
initial concentration: 1.0
is: HMDB00174

metaR r0830
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000185
modifier: MODEL1310110054#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/3.5.4.16
reversible: true
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
is described by: ECO:0000000

metaR r1011
is described by: ECO:0000000
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
reversible: false
fast: false
product: MODEL1310110054#
name: Transport reaction
type: Reaction
is: SBO:0000185

metaM dhcholoylcoa x
constant: false
boundary condition: false
is: CHEBI:27393
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: HMDB06895
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110054#_61ba9416_451b_439d_a59c_8a53a3b5c437
is: O14975
boundary condition: true
initial amount: NaN
constant: false
name: SLC27A2
is encoded by: hsa:11001
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaR FBP
type: Reaction
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.1.3.11
reversible: false
modifier: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
product: MODEL1310110054#
name: fructose-bisphosphatase
fast: false
notes: GENE_ASSOCIATION: (2203.1) or (8789.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.11 Confidence Level: 0 AUTHORS: PMID:9678974 NOTES:SMP
is: SBO:0000176

metaM Ser Thr l
name: protein-linked serine or threonine residue (O-glycosylation site)
is: HMDB00224
boundary condition: false
notes: FORMULA: XH CHARGE: 0
is: SBO:0000247
is: CHEBI:58190
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN

metaR VLCSp
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
modifier: MODEL1310110054#
is: SBO:0000176
is described by: ECO:0000269
fast: false
product: MODEL1310110054#
name: Very-long-chain-fatty-acid-CoA ligase
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110054#_687bd7b7_fd7b_43d4_a059_98dbb6657390
constant: false
has only substance units: false
is encoded by: hsa:10599
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q9Y6L6
initial concentration: NaN
type: Species
name: SLCO1B1

metaM amet r
type: Species
notes: FORMULA: C15H23N6O5S CHARGE: 1 INCHI: InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15414
constant: false
name: S-adenosyl-L-methionine
is: HMDB01185
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_849e58dd_72cd_41b7_8c40_7143c08a3982
constant: false
is encoded by: hsa:100287639
name: _100287639_1_c
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaR r2516
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110054#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110054#

metaR PSP L
product: MODEL1310110054#
modifier: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
type: Reaction
name: phosphoserine phosphatase (L-serine)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.3
reversible: false
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110054#

metaR B3GNT36g
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110054#
is described by: ECO:0000269
type: Reaction
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
modifier: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110054#_a1bee6b3_2b17_4b7f_ab63_58af3656d745
is encoded by: hsa:1808
is: SBO:0000252
initial amount: NaN
name: DPYSL2
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: B4DR31
constant: false

metaM ksi pre34 g
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 34
is: HMDB00175
is: C00130
is: CHEBI:58053
notes: FORMULA: C241H385N17O202S10X CHARGE: -11

metaM stcoa m
is: C00412
is: CHEBI:57394
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: Stearoyl-CoA (n-C18:0CoA)
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
has only substance units: false
type: Species
constant: false
is: HMDB01114
boundary condition: false

metaR FE3MTP1
is described by: ECO:0000134
fast: false
name: transport of ferrous iron into blood
modifier: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
kinetic law: MODEL1310110054#
reversible: false
type: Reaction
product: MODEL1310110054#

metaR r1010
type: Reaction
reversible: true
fast: false
product: MODEL1310110054#
is described by: ECO:0000000
name: Postulated transport reaction
is: SBO:0000185
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaM fuc12gal14acglcgalgluside hs g
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
name: Type IIH glycolipid
notes: FORMULA: C50H89N2O26FULLRCO CHARGE: 0
is: CHEBI:57847
constant: false
initial concentration: 1.0
is: HMDB00304
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_a6bc9817_e6aa_4267_8f8b_53934bf2de32
is encoded by: hsa:6576
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is: D9HTE9
name: SLC25A1
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_6a8d05aa_381d_49c4_aa77_636f40dfd501
initial concentration: NaN
initial amount: NaN
name: _F23536_1_m
boundary condition: true
is encoded by: hsa:F23536
has only substance units: false
constant: false
is: SBO:0000252
type: Species

metaM ala L c
type: Species
is: CHEBI:16977
is: HMDB00161
name: L-alanine
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: SBO:0000247
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_a8d11f61_e153_448a_bcdd_d2c13fb7fbde
boundary condition: true
constant: false
initial amount: NaN
name: GCK
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2645

metaR RE1520M
name: RE1520
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
modifier: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#
is: SBO:0000176
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110054#_d9c69130_6ee5_4daf_8cbf_0884216672a8
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: GALNT5
boundary condition: true
is encoded by: hsa:11227
is: A5PKZ1

http://identifiers.org/biomodels.db/MODEL1310110054#_c2e3889b_4540_45ac_a190_b7fc56242e5f
initial amount: NaN
is: Q308M7
name: ENPP3
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:5169

metaM dha e
is: HMDB01882
boundary condition: false
initial concentration: 1.0
name: glycerone
type: Species
constant: false
is: CHEBI:16016
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR THRGLYexR
kinetic law: MODEL1310110054#
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110054#
is described by: ECO:0000304
modifier: MODEL1310110054#
product: MODEL1310110054#
reversible: true
name: L-threonine/glycine reversible exchange
fast: false
type: Reaction

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

metaR MI1PP
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000176
product: MODEL1310110054#
name: myo-inositol 1-phosphatase
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
reversible: false
fast: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.25
reactant: MODEL1310110054#

metaR DHCRD2
fast: false
product: MODEL1310110054#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
reversible: false
name: dihydroceramide desaturase
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#

metaR LEUKTRD4t
product: MODEL1310110054#
reversible: true
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000185
name: leukotriene D4 transport

metaM fn2m2masn g
is: SBO:0000247
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
type: Species
constant: false
is: CHEBI:32984
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR DOLMANP Uter
fast: false
is described by: ECO:0000000
product: MODEL1310110054#
reversible: false
reactant: MODEL1310110054#
name: dolichol-phosphate mannose flippase (uterus)
kinetic law: MODEL1310110054#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_6537de06_da77_4d77_b962_e13d62d8ed7d
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
name: NDUFB8
is: O95169
is encoded by: hsa:4714
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_ab60fd09_0b7b_41e5_b34a_eeb9d4bab336
type: Species
boundary condition: true
is: Q9NWU1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:54995
constant: false
initial amount: NaN
name: OXSM
has only substance units: false

metaR r2514
reversible: true
name: Utilized transport
fast: false
product: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
type: Reaction
kinetic law: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_9fd98c6f_7230_4e58_a5a7_c920df87b5da
constant: false
name: PIGN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:23556
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_3d609c6c_b00a_4bdc_b475_ab90ad0393bf
name: ALDH4A1
is encoded by: hsa:8659
initial amount: NaN
is: P30038
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
constant: false

metaR SMPD4
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
product: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
name: sphingomyelinase
reversible: false
is: SBO:0000176
reactant: MODEL1310110054#
fast: false
type: Reaction

metaR CSPG Etly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
product: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110054#
fast: false
reversible: false
name: chondroitin sulfate E transport, extracellular to lysosome

http://identifiers.org/biomodels.db/MODEL1310110054#_7520aac1_ea4a_4dc2_8c77_c521e1b4c1ef
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:53354
name: PANK1
type: Species
initial amount: NaN

metaM Ser Thr g
boundary condition: false
constant: false
notes: FORMULA: XH CHARGE: 0
name: protein-linked serine or threonine residue (O-glycosylation site)
is: SBO:0000247
initial concentration: 1.0
is: HMDB00645
is: CHEBI:58336
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_91d8d1ea_985d_4e7e_a1b3_72f339547d2f
constant: false
initial amount: NaN
is encoded by: hsa:1103
type: Species
is: Q6LEN6
initial concentration: NaN
is: SBO:0000252
name: CHAT
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_65dd2bf5_b479_499e_a295_72a773bee399
is: SBO:0000252
is: B7Z3U6
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:476
constant: false
name: ATP1A1

metaM 1p3h5c m
is: HMDB01369
boundary condition: false
is: CHEBI:6151
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
type: Species
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281

http://identifiers.org/biomodels.db/MODEL1310110054#_93571541_b44f_455a_9dde_b05f4ca766fc
boundary condition: true
initial concentration: NaN
name: PIGP
is encoded by: hsa:51227
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
constant: false

metaR ADK3
kinetic law: MODEL1310110054#
name: adentylate kinase (GTP)
fast: false
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.4.3
product: MODEL1310110054#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
is: SBO:0000176
type: Reaction
reversible: true
reactant: MODEL1310110054#

metaM gal1p c
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
is: CHEBI:58336
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00645
constant: false
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
is: SBO:0000247

metaR NACHEX1ly
is: SBO:0000176
product: MODEL1310110054#
reactant: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110054#_342cb7d6_706e_4015_a5f1_972631e61c21
type: Species
initial concentration: NaN
is encoded by: hsa:8309
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is: Q99424
boundary condition: true
name: ACOX2

metaM crtsl r
is: SBO:0000247
type: Species
constant: false
is: HMDB00063
has only substance units: false
is: CHEBI:17650
notes: FORMULA: C21H30O5 CHARGE: 0 INCHI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00735
name: cortisol
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR THD1m
is version of: http://identifiers.org/ec-code/1.6.1.2
is: SBO:0000185
type: Reaction
name: NAD(P) transhydrogenase
fast: false
reactant: MODEL1310110054#
product: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES:TDV (2-6-2003)
is described by: ECO:0000269
modifier: MODEL1310110054#

metaM m1mpdol U c
constant: false
initial amount: NaN
notes: FORMULA: C1305H2140N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
boundary condition: false
has only substance units: false
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:28067

http://identifiers.org/biomodels.db/MODEL1310110054#_10cc715d_397a_493f_990d_db42435c61fc
initial concentration: NaN
boundary condition: true
is: Q99685
is encoded by: hsa:11343
type: Species
name: MGLL
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false

metaR MAN6PI
reactant: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.8
product: MODEL1310110054#
name: mannose-6-phosphate isomerase
modifier: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
is described by: ECO:0000304
fast: false

metaM CE4795 x
is: SBO:0000247
name: 2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
type: Species
is: CHEBI:57923
initial amount: NaN
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,18-21,28-30,34-36,40,51-52H,4-7,10,13,16-17,22-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,19-18-,21-20+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4795

metaR RE0344C
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000000
reactant: MODEL1310110054#
product: MODEL1310110054#
modifier: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
name: RE0344
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110054#

metaR CYTK11
reactant: MODEL1310110054#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
name: cytidylate kinase (dCMP,dGTP)
reversible: true
modifier: MODEL1310110054#

metaR BTNt4i
reactant: MODEL1310110054#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
reversible: false
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
fast: false
is: SBO:0000185
name: Biotin uptake (antiport)

metaR r1786
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110054#
fast: false
modifier: MODEL1310110054#
is: SBO:0000185
name: Y+LAT2 Utilized transport
product: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR S6T5g
type: Reaction
reactant: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110054#
is: SBO:0000176
product: MODEL1310110054#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
modifier: MODEL1310110054#
reversible: false

metaM m3mpdol U c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C1425H2340N20O370P20 CHARGE: -20
boundary condition: false
type: Species
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human uterine homolog
is: CHEBI:37632
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_9832d2fb_f4d5_458e_9d44_b44a3249d5ce
type: Species
is encoded by: hsa:3945
initial concentration: NaN
name: LDHB
constant: false
is: SBO:0000252
is: P07195
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_37b6a5fb_4111_4235_b26b_63ec919ef9bc
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: SLC6A9
is encoded by: hsa:6536
boundary condition: true
is: B7Z3W8
type: Species
has only substance units: false

metaM frdp c
has only substance units: false
initial amount: NaN
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: HMDB00961
type: Species
is: CHEBI:175763
is: SBO:0000247
constant: false
name: Farnesyl diphosphate
initial concentration: 1.0
boundary condition: false
is: C00448

metaR CYSO
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.13.11.20
fast: false
name: cysteine oxidase
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
is described by: ECO:0000269
reversible: false
type: Reaction
modifier: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000176

metaR 5HLTDL
is version of: http://identifiers.org/ec-code/4.1.1.28
is: SBO:0000176
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:1540578 NOTES:SAB
is described by: ECO:0000269
name: 5-Hydroxy-L-tryptophan decarboxy-lyase
reversible: false
type: Reaction
reactant: MODEL1310110054#
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
product: MODEL1310110054#

metaR r2140
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
type: Reaction
reactant: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#
fast: false
product: MODEL1310110054#
modifier: MODEL1310110054#

metaM adp n
name: ADP(3-)
has only substance units: false
type: Species
boundary condition: false
is: HMDB01341
is: CHEBI:456216
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_ea9c8db9_c879_445b_aef9_52a93097bb62
constant: false
has only substance units: false
type: Species
name: PSPH
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5723
is: SBO:0000252
is: P78330

metaM sgalside hs g
is: HMDB00061
constant: false
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:58343
initial amount: NaN
is: SBO:0000247
name: sulfatide galactocerebroside
initial concentration: 1.0

metaR CYTK10
fast: false
reversible: true
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reactant: MODEL1310110054#
name: cytidylate kinase (CMP,dGTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR r2405
reversible: false
product: MODEL1310110054#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
fast: false
type: Reaction
kinetic law: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110054#_f56b8a21_3bde_4852_a5c2_d77d68401dfe
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: SLC7A2
is: P52569
constant: false
is encoded by: hsa:6542
type: Species
initial amount: NaN
boundary condition: true

metaR 4NPHte
type: Reaction
name: xenobiotic transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
is: SBO:0000185
kinetic law: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
is described by: ECO:0000000
product: MODEL1310110054#

metaM akg x
constant: false
is: HMDB00208
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
type: Species
is: CHEBI:16810
name: 2-oxoglutarate(2-)

metaR r2141
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110054#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110054#

metaR CYTK13
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
product: MODEL1310110054#
modifier: MODEL1310110054#
name: cytidylate kinase (dCMP,dATP)
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
type: Reaction

metaM rbt c
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:15963
name: D-ribitol
has only substance units: false
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: HMDB00508

metaM acglcgal14acglcgalgluside hs g
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
initial amount: NaN
constant: false
name: nLc5Cer
is: CHEBI:17103

http://identifiers.org/biomodels.db/MODEL1310110054#_b98723af_7ca4_4896_b11a_810e9f0f4fde
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
name: CHAT
is: D3DX95
boundary condition: true
is encoded by: hsa:1103
initial amount: NaN
has only substance units: false

metaR r1019
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
type: Reaction
fast: false
is: SBO:0000185
name: Postulated transport reaction
reactant: MODEL1310110054#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110054#

metaR ASNTHRNaEx
name: L-threonine/L-asparagine Na-dependent exchange (Asn-L in)
fast: false
modifier: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
kinetic law: MODEL1310110054#
is: SBO:0000185
type: Reaction
reversible: false

metaM prostgf2 c
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB01139
name: prostaglandin F2alpha(1-)
is: CHEBI:57404
has only substance units: false
initial amount: NaN
constant: false

metaR r2142
kinetic law: MODEL1310110054#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110054#
is described by: ECO:0000000
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reversible: true
fast: false
product: MODEL1310110054#

metaR CYTK12
product: MODEL1310110054#
type: Reaction
reversible: true
kinetic law: MODEL1310110054#
is: SBO:0000176
reactant: MODEL1310110054#
fast: false
name: cytidylate kinase (dCMP,dCTP)
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110054#_83a553ea_e1b9_4c68_bdf5_0bb8db73516c
constant: false
initial concentration: NaN
name: _AI191472_1_c
is encoded by: hsa:AI191472
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_451be86f_ad83_4112_923f_2a689ffadf4c
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8694
constant: false
is: O75907
has only substance units: false
name: DGAT1
boundary condition: true

metaM lnlccrn m
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: Linoleyl carnitine
type: Species
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
constant: false
initial concentration: 1.0
is: HMDB06469
has only substance units: false

metaR GULNter
name: L-gulonate endoplasmic reticular export
type: Reaction
product: MODEL1310110054#
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110054#

metaM ksi deg1 e
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:17268
constant: false
name: keratan sulfate I, degradation product 1
type: Species
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
has only substance units: false
is: SBO:0000247
is: HMDB00211

metaR r1569
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: true
product: MODEL1310110054#
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_f56d387a_c854_4242_8c83_7506426b57b3
initial amount: NaN
boundary condition: true
type: Species
name: PEMT
constant: false
is encoded by: hsa:10400
is: SBO:0000252
has only substance units: false
is: Q9UBM1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_fae709cd_581c_4dbc_8de6_2d90028028bf
has only substance units: false
is: SBO:0000252
is: P40394
is encoded by: hsa:131
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
type: Species
name: ADH7

metaR r1018
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
product: MODEL1310110054#
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:

metaR EX srtn LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Serotonin exchange
type: Reaction

metaM rbt e
constant: false
initial concentration: 1.0
name: D-ribitol
boundary condition: false
is: CHEBI:15963
initial amount: NaN
is: HMDB00508
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
type: Species
is: SBO:0000247

metaR DMNONCRNCPT2
kinetic law: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
name: DMNONCRNCPT2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
product: MODEL1310110054#

metaM cs a deg5 l
is: SBO:0000247
notes: FORMULA: C23H36O24S CHARGE: -2
constant: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
initial amount: NaN
has only substance units: false
is: CHEBI:15936
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_4ada9bc4_0073_4f5f_a83d_5c8e0e66e048
is: P04745
constant: false
name: AMY1B
is encoded by: hsa:277
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252

metaR O2Stn
is: SBO:0000185
kinetic law: MODEL1310110054#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110054#
product: MODEL1310110054#
name: superoxide anion transport via diffusion (nucleus)
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
fast: false

metaR FAOXC123m
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

metaM tdchola c
has only substance units: false
is: CHEBI:9407
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: SBO:0000247
is: HMDB00951
boundary condition: false
constant: false
name: taurochenodeoxycholate
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_d7e22ce6_2f7d_4820_9a0a_0bae7f77c73c
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: HK1
initial concentration: NaN
is encoded by: hsa:3098
is: A8K7J7
type: Species
boundary condition: true

metaR r1782
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110054#
reversible: false
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110054#
name: Y+LAT2 Utilized transport

metaR ALOX5
fast: false
type: Reaction
reactant: MODEL1310110054#
modifier: MODEL1310110054#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.13.11.34
name: Arachidonate 5-lipoxygenase
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe
product: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#

metaR G14T21g
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
kinetic law: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110054#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110054#
is: SBO:0000176

metaR r2408
reactant: MODEL1310110054#
modifier: MODEL1310110054#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is described by: ECO:0000000
product: MODEL1310110054#
fast: false
type: Reaction
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185

metaR DNDPt24m
fast: false
is described by: ECO:0000269
modifier: MODEL1310110054#
reversible: false
reactant: MODEL1310110054#
name: dTDP transport via dADP antiport
type: Reaction
is: SBO:0000185
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110054#

metaM 2ddecdicoa x
has only substance units: false
type: Species
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: C05279
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
name: 2,6-dodecadienoylcoa
is: HMDB11123
initial concentration: 1.0

metaR r1017
is described by: ECO:0000000
reversible: false
product: MODEL1310110054#
type: Reaction
name: Vesicular transport
is: SBO:0000185
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12663868,PMID:14716480,PMID:15209530,PMID:15297262,PMID:1599411,PMID:17416343,PMID:9068608 NOTES:
reactant: MODEL1310110054#
fast: false

metaR HSD17B4x
fast: false
reversible: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
name: hydroxysteroid (17-beta) dehydrogenase 4
is described by: ECO:0000269
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110054#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110054#

metaM adp r
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:456216
initial amount: NaN
name: ADP(3-)
constant: false
is: HMDB01341

metaM sgalside hs c
is: HMDB03406
constant: false
type: Species
name: sulfatide galactocerebroside
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:16523
boundary condition: false
initial amount: NaN
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1

metaR CYTK14
type: Reaction
product: MODEL1310110054#
is: SBO:0000176
reactant: MODEL1310110054#
reversible: true
fast: false
kinetic law: MODEL1310110054#
is described by: ECO:0000269
name: cytidylate kinase (dCMP,UTP)
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR PHYHx
reversible: false
fast: false
is described by: ECO:0000269
product: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (5264.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.14.11.18 Confidence Level: 4 AUTHORS: PMID:8954107,PMID:9326940 NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.14.11.18
type: Reaction
name: Phytanoyl-CoA dioxygenase, peroxisomal

metaR CHLtm
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110054#
reversible: true
product: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
fast: false
name: choline transport via diffusion (cytosol to mitochondria)
is described by: ECO:0000000

metaM stcoa c
constant: false
initial concentration: 1.0
is: CHEBI:57394
boundary condition: false
has only substance units: false
is: HMDB01114
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
type: Species
is: C00412
name: Stearoyl-CoA (n-C18:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110054#_0b8171f9_f020_4a35_bf92_dddd19fed44e
is: SBO:0000252
initial amount: NaN
name: _AD000092_1_c
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:AD000092

metaR FAOXC184C164m
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_2dae8554_e1d5_4f7b_afe7_520cb9787342
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:5152
name: PDE9A
initial concentration: NaN
constant: false
boundary condition: true
type: Species

metaM cs b deg1 l
is: SBO:0000247
boundary condition: false
is: HMDB00812
constant: false
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:16953
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
initial amount: NaN

metaR L LACDcm
reversible: false
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000185
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (124637.1) SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:18831974 NOTES:NCD/TDV. This reaction exists in yeast, but no evidence could be found this exists in humans. However, there may be intramitochondrial lactate dehydrogenase and lactate transport into mitochondria
fast: false
type: Reaction
name: L-Lactate dehydrogenase, cytosolic/mitochondrial
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110054#_dce01477_2789_453d_842d_888fa774174c
name: ATP2B2
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is: Q4J699
is encoded by: hsa:491

metaM urcan c
boundary condition: false
is: SBO:0000247
constant: false
name: Urocanate
is: C00785
is: CHEBI:17771
is: HMDB00301
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
initial amount: NaN

metaM gtp m
is: CHEBI:37565
initial amount: NaN
is: C00044
name: GTP
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB01273
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_43340643_52d4_423e_95f1_5e8cd2738eb4
constant: false
initial amount: NaN
is: P14672
is encoded by: hsa:6517
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
name: SLC2A4
has only substance units: false

metaR r0909
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110054#
is: SBO:0000185
reversible: true
name: Transport reaction
kinetic law: MODEL1310110054#
fast: false
type: Reaction
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_23c054e2_7ad5_4533_8a78_440ff4193d09
is encoded by: hsa:5464
is: Q15181
is: SBO:0000252
has only substance units: false
constant: false
name: PPA1
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_494d79c4_b175_45e8_af25_cc73fa704028
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: PMVK
type: Species
is encoded by: hsa:10654
constant: false
initial amount: NaN
is: Q6FGV9
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_23c3dd71_5db7_43fe_8f75_f20fedb9c4ed
initial amount: NaN
has only substance units: false
is: Q92643
initial concentration: NaN
constant: false
name: PIGK
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10026

http://identifiers.org/biomodels.db/MODEL1310110054#_dda6bf49_963f_42ff_90d2_601b2b4109b1
is encoded by: hsa:2678
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
name: GGT1
has only substance units: false
boundary condition: true
type: Species

metaR r1565
product: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_9bcdd6db_1b58_424c_9d3d_3fdaafff2d94
is encoded by: hsa:6547
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
name: SLC8A3
is: SBO:0000252
initial amount: NaN
type: Species

metaR HS4ly
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
name: heparan-N-sulfatase, lysosomal
reversible: false
modifier: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/3.10.1.1
product: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#

metaM galgalgalthcrm hs c
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
type: Species
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
constant: false
is: CHEBI:12936
initial concentration: 1.0
is: HMDB00143
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR LNSTLSr
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
type: Reaction
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/5.4.99.7
is described by: ECO:0000134
reversible: false
reactant: MODEL1310110054#
modifier: MODEL1310110054#
name: lanosterol synthase
fast: false
is: SBO:0000176

metaR O2Stm
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110054#
fast: false
type: Reaction
reactant: MODEL1310110054#
name: superoxide anion transport via diffusion (mitochondria)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reversible: true
product: MODEL1310110054#

metaR r0908
is described by: ECO:0000000
reactant: MODEL1310110054#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
name: Postulated transport reaction
kinetic law: MODEL1310110054#
type: Reaction
reversible: true
product: MODEL1310110054#

metaM 4hoxpacd c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
constant: false
is: SBO:0000247
name: (4-hydroxyphenyl)acetaldehyde
has only substance units: false
boundary condition: false
is: CHEBI:15621
is: HMDB03767
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_43715140_154b_4f89_b866_bc5c2356ff76
is encoded by: hsa:8372
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
name: HYAL3
is: SBO:0000252
is: O43820

metaM chol e
is: CHEBI:15354
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: C00114
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: Choline
constant: false
is: HMDB00097

metaR AG13T10g
fast: false
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110054#
is described by: ECO:0000000
reactant: MODEL1310110054#
reversible: false
type: Reaction
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176

metaM tchola x
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
initial concentration: 1.0
is: CHEBI:36257
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00036
has only substance units: false
name: taurocholate
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_fc709835_80f3_4f6e_a80f_badef3b57cda
type: Species
is encoded by: hsa:514
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: P56381
is: SBO:0000252
name: ATP5E
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_764b8c20_c680_4ee6_94c1_79dc06d2ebac
constant: false
initial concentration: NaN
is encoded by: hsa:7167
has only substance units: false
boundary condition: true
name: TPI1
initial amount: NaN
type: Species
is: SBO:0000252
is: Q53HE2

metaM l2n2m2mn l
type: Species
initial amount: NaN
notes: FORMULA: C54H91N3O41 CHARGE: 0
has only substance units: false
is: SBO:0000247
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
is: CHEBI:12936
is: HMDB00143
boundary condition: false
initial concentration: 1.0
constant: false

metaM akg m
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:16810
initial concentration: 1.0
name: 2-Oxoglutarate
has only substance units: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: HMDB00208
type: Species
is: C00026
boundary condition: false

metaM eitetcoa x
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
constant: false
name: 5,8,11,14-eicosatetraenoylcoa
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false

metaM dopasf c
initial concentration: 1.0
is: HMDB06275
name: dopamine 3-O-sulfate
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
boundary condition: false
is: CHEBI:37946
constant: false

metaM dec24dicoa x
constant: false
is: HMDB01168
has only substance units: false
name: 2,4-decadienoylcoa
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN

metaR CO2tp
reversible: true
name: CO2 peroxisomal transport
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR r1566
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_a062e0fe_2ada_4a4d_8c16_d77a57864568
boundary condition: true
name: FH
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P07954
is encoded by: hsa:2271

metaR DHPM1
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
reversible: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.2.2
fast: false
kinetic law: MODEL1310110054#
is described by: ECO:0000269
product: MODEL1310110054#
modifier: MODEL1310110054#
name: dihydropyrimidinase (5,6-dihydrouracil)

http://identifiers.org/biomodels.db/MODEL1310110054#_ef1d534c_828d_45cb_a52a_39db818f0478
is: P51178
name: PLCD1
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5333
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_304e36c5_dec9_4c1a_866f_b175ddd4d683
initial concentration: NaN
has only substance units: false
name: SLC23A1
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:9963
constant: false

metaR r2133
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110054#
fast: false
is: SBO:0000185
reactant: MODEL1310110054#
product: MODEL1310110054#
modifier: MODEL1310110054#

metaM acgbgbside hs g
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00215
initial concentration: 1.0
is: CHEBI:17411
has only substance units: false
name: beta GalNAc globoside
constant: false
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
type: Species

metaR ADRNCOAtx
kinetic law: MODEL1310110054#
is: SBO:0000185
product: MODEL1310110054#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110054#
reversible: true
type: Reaction
name: fatty acid intracellular transport

metaR 3HKYNAKGAT
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
modifier: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.6.1.7
reversible: false
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.6.1.64
reactant: MODEL1310110054#
is: SBO:0000176
fast: false

metaM glyald m
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17378
boundary condition: false
name: D-glyceraldehyde
type: Species
is: HMDB01051
constant: false
has only substance units: false
is: SBO:0000247

metaR r2136
is described by: ECO:0000000
reactant: MODEL1310110054#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
reversible: false
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
fast: false
type: Reaction
is: SBO:0000185

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaM HC02205 e
is: CHEBI:28099
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
name: prostaglandin-b2
boundary condition: false

metaR r1567
product: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_573fa20b_0e62_450d_a5db_f23d8a8e0bc5
is: Q9H0N5
constant: false
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:84105
initial concentration: NaN
is: SBO:0000252
name: PCBD2
boundary condition: true

metaM galgalgalthcrm hs e
type: Species
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
constant: false
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
is: HMDB00143
is: CHEBI:0
initial amount: NaN
initial concentration: 1.0
is: C00124
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_f4deb7aa_8c40_48d7_a952_fc167cbf97e5
is: B7Z5G2
initial amount: NaN
is encoded by: hsa:2629
type: Species
is: SBO:0000252
name: GBA
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true

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is: O60503
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
name: ADCY9
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:115

metaM gtp n
initial concentration: 1.0
name: GTP(4-)
is: SBO:0000247
is: CHEBI:37565
constant: false
has only substance units: false
boundary condition: false
is: HMDB01273
type: Species
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial amount: NaN

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name: ACSL1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2180
boundary condition: true
has only substance units: false
type: Species
is: P33121
constant: false

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type: Species
initial amount: NaN
initial concentration: NaN
is: O00757
is: SBO:0000252
constant: false
name: FBP2
has only substance units: false
boundary condition: true
is encoded by: hsa:8789

metaR r1568
is: SBO:0000185
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110054#
reactant: MODEL1310110054#
reversible: true
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_700226a0_6e45_4562_81fd_1bf663ee6ee4
type: Species
boundary condition: true
name: ACAD9
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:28976
initial concentration: NaN
is: Q9H845
is: SBO:0000252

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type: Species
is: SBO:0000252
initial amount: NaN
is: F8W1L5
boundary condition: true
constant: false
is encoded by: hsa:2819
initial concentration: NaN
name: GPD1
has only substance units: false

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initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: SLC2A10
constant: false
type: Species
is encoded by: hsa:81031
is: O95528
has only substance units: false

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initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
name: _BF195998_1_x
is encoded by: hsa:BF195998

metaM pdx5p c
notes: FORMULA: C8H10NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00459 EHMN_ABBREVIATION: C00627
is: CHEBI:58589
name: Pyridoxine 5'-phosphate
is: C00627
constant: false
initial amount: NaN
type: Species
is: HMDB01319
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

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initial concentration: NaN
initial amount: NaN
is: Q5JRA6
name: MIA3
type: Species
is encoded by: hsa:375056
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false

metaR 1PPDCRp
reversible: false
type: Reaction
reactant: MODEL1310110054#
product: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#
is: SBO:0000176
is described by: ECO:0000000
name: delta1-piperideine-2-carboxylate reductase, perixosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM

metaR r1787
is described by: ECO:0000000
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110054#
reversible: false
fast: false
reactant: MODEL1310110054#
product: MODEL1310110054#
type: Reaction

metaR DOLPGT1 Uer
is: SBO:0000176
reversible: false
modifier: MODEL1310110054#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
type: Reaction
kinetic law: MODEL1310110054#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10359825 NOTES:EC 2.4.1.- NCD
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.1.267
product: MODEL1310110054#

metaM HC00319 c
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial amount: NaN
type: Species
boundary condition: false
constant: false
name: Malonate
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:30794
has only substance units: false

metaR MI1P Dtn
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110054#
reversible: true
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110054#
fast: false
is described by: ECO:0000000
name: inositol 1-phosphate nuclear transport (diffusion)

metaM tdchola x
has only substance units: false
is: SBO:0000247
is: HMDB00951
constant: false
initial amount: NaN
type: Species
name: taurochenodeoxycholate
boundary condition: false
is: CHEBI:9407
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial concentration: 1.0

metaM retinol c
constant: false
is: SBO:0000247
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00305
name: retinol
type: Species
is: CHEBI:50211

metaR GAL3ST11
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
reversible: false
type: Reaction
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000000
name: Galactosylceramide sulfotransferase
is version of: http://identifiers.org/ec-code/2.8.2.11

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaM acgbgbside hs l
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00215
constant: false
initial amount: NaN
is: CHEBI:17411
type: Species
name: beta GalNAc globoside

metaM cs e deg2 l
type: Species
is: HMDB00812
initial amount: NaN
constant: false
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
is: CHEBI:16953
boundary condition: false

metaR r1561
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110054#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_5b7d423c_9b44_445b_a4e3_32b93e613737
constant: false
name: SHMT1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6470
initial amount: NaN
type: Species
has only substance units: false

metaR URAt
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
type: Reaction
product: MODEL1310110054#
name: uracil transport via facilated diffusion
fast: false
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110054#
modifier: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#

metaM CE2420 m
is: HMDB11123
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
is: CHEBI:28387
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM ksi deg20 l
is: HMDB00143
is: CHEBI:12936
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
boundary condition: false
constant: false
is: SBO:0000247
name: keratan sulfate I, degradation product 20
initial amount: NaN

metaM bilirub e
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial amount: NaN
is: HMDB00054
constant: false
is: CHEBI:57977
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: bilirubin(2-)

http://identifiers.org/biomodels.db/MODEL1310110054#_2a6a8c24_69fe_40ac_94f3_915f69af50d7
constant: false
is: SBO:0000252
initial amount: NaN
name: NME6
has only substance units: false
is encoded by: hsa:10201
is: O75414
initial concentration: NaN
type: Species
boundary condition: true

metaR EX ins LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Inosine exchange
type: Reaction

metaR ATP1ter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
name: ADP/ATP transporter, endoplasmic reticulum
kinetic law: MODEL1310110054#

metaR C4STMO1r
is: SBO:0000176
modifier: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
is version of: http://identifiers.org/ec-code/1.14.13.72
kinetic law: MODEL1310110054#
fast: false
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
reversible: false

metaM dctp c
name: dCTP
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
initial concentration: 1.0
is: HMDB00998
is: C00458
boundary condition: false
initial amount: NaN
is: CHEBI:16311
constant: false

metaR r2137
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
reactant: MODEL1310110054#
reversible: true
modifier: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
type: Reaction
kinetic law: MODEL1310110054#
fast: false
is described by: ECO:0000000

metaM galthcrm hs g
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: Gal-Gal-Gal-Glc-Cer
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:26174
notes: FORMULA: C42H76NO22FULLRCO CHARGE: 0

metaM retinol e
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: CHEBI:50211
name: retinol
initial amount: NaN
is: HMDB00305
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_e42ebc7a_936d_4196_b967_7c2e2e8dee27
boundary condition: true
is encoded by: hsa:113
is: P51828
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
name: ADCY7
type: Species

metaR r1562
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR RETt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110054#
product: MODEL1310110054#
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110054#
name: Retinol transport via faciliated diffusion
is described by: ECO:0000000
is: SBO:0000185

metaR r1789
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
product: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_e2f67465_30bc_4861_b271_5dc2f39762bf
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
name: HAGH
is: Q16775
type: Species
is encoded by: hsa:3029

metaM Rtotal2coa c
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
is: HMDB01564
initial concentration: 1.0
is: CHEBI:57876
name: R total 2 coenzyme A
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_de5297f5_5976_422d_a551_68ddac105942
is: SBO:0000252
name: _T83654_1_m
type: Species
is encoded by: hsa:T83654
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_911e93ab_5246_4075_8516_98cbb8777068
type: Species
name: DGKG
is: P49619
is encoded by: hsa:1608
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN

metaM chol c
is: HMDB00097
boundary condition: false
initial concentration: 1.0
is: CHEBI:15354
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial amount: NaN
is: SBO:0000247
is: C00114
type: Species
name: Choline
constant: false
has only substance units: false

metaM docohexcoa x
type: Species
initial concentration: 1.0
name: 2,4,7,10,13,16-docosahexenoylcoa
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
constant: false

metaM bilirub c
constant: false
is: CHEBI:57977
name: bilirubin(2-)
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00054
boundary condition: false
has only substance units: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486

metaR ADK1
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000269
reversible: true
name: adenylate kinase
is: SBO:0000176
reactant: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110054#

metaR PRGSTRNt
name: Progesterone transport
product: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaR r1563
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110054#
reactant: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110054#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR r1564
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000000
reactant: MODEL1310110054#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_a44c9adf_4dab_4d47_a65f_96ce2f8e4e44
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:89869
is: Q86YW0
boundary condition: true
constant: false
name: PLCZ1
is: SBO:0000252

metaR HISTAtu
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
reversible: true
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
name: Histamine uniport
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
product: MODEL1310110054#

metaM dopasf e
is: HMDB06275
is: CHEBI:37946
constant: false
name: dopamine 3-O-sulfate
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
is: SBO:0000247

metaR r2139
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
product: MODEL1310110054#
modifier: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaM Asn X Ser Thr r
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28938
name: protein-linked asparagine residue (N-glycosylation site)
notes: FORMULA: XH CHARGE: 0
is: HMDB00051
has only substance units: false
initial amount: NaN
boundary condition: false
is: C01342
constant: false
type: Species

metaR VLCS2r
name: Very-long-chain-fatty-acid-CoA ligase
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
product: MODEL1310110054#
is described by: ECO:0000304
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
reversible: false
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_metaR_EX_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIAb exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_1285d9f9_be3b_4a83_ab34_a5355b21b421
name: UEVLD
initial concentration: NaN
is: Q8IX04
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:55293
has only substance units: false

metaR r1451
product: MODEL1310110054#
name: EC:1.3.3.6
kinetic law: MODEL1310110054#
is: SBO:0000176
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110054#_6ed505bb_f4dc_4a5b_a9a9_9e8cc0e8f5eb
constant: false
name: GOT2
type: Species
is encoded by: hsa:2806
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P00505
has only substance units: false

metaR r0617
type: Reaction
reactant: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
kinetic law: MODEL1310110054#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
fast: false

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_a510a8e7_56de_4ead_a842_a9826407603d
type: Species
is encoded by: hsa:3948
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: LDHC
boundary condition: true

metaR FUCASE2e
fast: false
reversible: false
name: alpha-fucosidase, extracellular
is version of: http://identifiers.org/ec-code/3.2.1.51
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:10460218,PMID:11389735,PMID:12604617,PMID:2317201 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110054#
modifier: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#

metaR NRPPHRSULT
reactant: MODEL1310110054#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
fast: false
reversible: false
modifier: MODEL1310110054#
is: SBO:0000176
name: Norepinephrine Sulfotransferase
is version of: http://identifiers.org/ec-code/2.8.2.1
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_b82a7458_c92a_4dd1_99dc_0e87e7ea4bcf
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:123041
is: Q8NFF2
initial concentration: NaN
type: Species
name: SLC24A4
has only substance units: false
initial amount: NaN

metaM akg e
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:16810
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: SBO:0000247
type: Species
is: HMDB00208
name: 2-oxoglutarate(2-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_f97670a4_e41e_4a36_94fa_6eb82a54873e
is: SBO:0000252
boundary condition: true
name: ND4L
is: Q7GXZ4
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:4539
type: Species
initial amount: NaN

metaM 4mlacac c
initial concentration: 1.0
type: Species
name: 4-maleylacetoacetate
is: HMDB02052
is: CHEBI:17105
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
has only substance units: false

metaM hco3 c
initial concentration: 1.0
has only substance units: false
is: C00288
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
boundary condition: false
is: CHEBI:17544
is: HMDB00595
constant: false
initial amount: NaN
type: Species
name: Bicarbonate
is: SBO:0000247

metaR r1678
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
reversible: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110054#
modifier: MODEL1310110054#

metaM glyald c
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:17378
constant: false
initial concentration: 1.0
is: HMDB01051
name: D-Glyceraldehyde
initial amount: NaN
is: C00577
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_8ec17142_1700_4ea9_b945_39248d19664a
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is: Q9HC58
initial concentration: NaN
name: SLC24A3
is encoded by: hsa:57419
has only substance units: false
constant: false

metaM gtp e
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
name: GTP(4-)
is: HMDB01273
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
constant: false
is: CHEBI:37565

metaR r0616
fast: false
is: SBO:0000176
product: MODEL1310110054#
modifier: MODEL1310110054#
reversible: true
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
type: Reaction

metaM gtp c
has only substance units: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
constant: false
is: C00044
initial concentration: 1.0
is: CHEBI:37565
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
is: HMDB01273
name: GTP

metaR r1453
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
is described by: ECO:0000000
product: MODEL1310110054#
reactant: MODEL1310110054#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
type: Reaction
fast: false

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaM Asn X Ser Thr l
is: C01342
is: HMDB00051
boundary condition: false
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:28938
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
name: protein-linked asparagine residue (N-glycosylation site)

metaM tststerone e
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17347
constant: false
is: HMDB00234
name: testosterone
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaM acglcgalgbside hs g
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0
boundary condition: false
name: GlcNAc-Gal globoside
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:26174
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_96afb763_3879_4e92_b793_2607a2961ce8
initial amount: NaN
type: Species
is encoded by: hsa:26275
initial concentration: NaN
boundary condition: true
has only substance units: false
name: HIBCH
is: SBO:0000252
constant: false
is: Q6NVY1

metaR r1679
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
product: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: false
modifier: MODEL1310110054#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_metaM_fucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
has only substance units: false
is: HMDB00257
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:16094
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_cf818ad2_5099_4e7e_a7d1_e63c70c48d5d
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:AA526438
name: _AA526438_1_m
constant: false
boundary condition: true
initial amount: NaN

metaR G14T10g
modifier: MODEL1310110054#
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110054#
type: Reaction
reversible: false
reactant: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90

metaR r0829
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110054#
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/4.1.1.37
type: Reaction
modifier: MODEL1310110054#
is described by: ECO:0000000
product: MODEL1310110054#
reactant: MODEL1310110054#
fast: false

metaR r0615
product: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000176
modifier: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is version of: http://identifiers.org/ec-code/2.3.1.168
fast: false
is described by: ECO:0000000

metaM arachcoa m
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
name: arachidyl coenzyme A
is: HMDB04258
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: CHEBI:15527
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_cd416015_60a6_40c1_9451_993c30dcf491
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2645
type: Species
boundary condition: true
is: Q53Y25
is: SBO:0000252
constant: false
name: GCK
initial amount: NaN

metaM homoval m
has only substance units: false
initial concentration: 1.0
name: Homovanillate
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
boundary condition: false
is: HMDB00118
is: CHEBI:545959
constant: false

metaM gsn c
initial amount: NaN
constant: false
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: C00387
name: Guanosine
is: SBO:0000247
is: HMDB00133
type: Species
initial concentration: 1.0
is: CHEBI:16750
boundary condition: false
has only substance units: false

metaR SPH1Pte
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
name: sph1p transport
reversible: true
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110054#_7c16c100_110d_4fb0_b91c_423e4ecf3295
is encoded by: hsa:2517
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is: P04066
boundary condition: true
constant: false
name: FUCA1

metaM hdcea c
is: HMDB03229
initial concentration: 1.0
constant: false
name: Hexadecenoate (n-C16:1)
is: SBO:0000247
is: CHEBI:32372
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850

http://identifiers.org/biomodels.db/MODEL1310110054#_9e56f185_1615_475c_9261_c4696a621cbc
is: B7Z6M3
boundary condition: true
initial concentration: NaN
type: Species
name: DGKZ
is encoded by: hsa:8525
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN

metaR THFtm
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is described by: ECO:0000000
reversible: true
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
reactant: MODEL1310110054#
product: MODEL1310110054#
fast: false
is: SBO:0000185
type: Reaction

metaR RE2999M
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
reactant: MODEL1310110054#
product: MODEL1310110054#
modifier: MODEL1310110054#
name: RE2999
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
kinetic law: MODEL1310110054#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110054#_07ff9c78_a24b_4241_b2fa_1c78010bad6f
initial concentration: NaN
is: P16066
boundary condition: true
name: NPR1
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:4881
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_e1948aec_1f52_4364_bdf0_2472c35ad0a3
is: SBO:0000252
is: O43916
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:8534
has only substance units: false
boundary condition: true
name: CHST1
initial amount: NaN

metaR r1560
is described by: ECO:0000000
product: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_72978b6d_e24e_4916_a17f_690258dad59f
boundary condition: true
name: ATP5G3
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:518
is: P48201
has only substance units: false
initial amount: NaN
constant: false
type: Species

metaR r0614
type: Reaction
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
kinetic law: MODEL1310110054#
is: SBO:0000176
fast: false
reactant: MODEL1310110054#
reversible: true
product: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110054#_247f8a7a_18e0_4ace_9d85_cb77235ee8f3
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P46459
is encoded by: hsa:4905
name: NSF
constant: false
initial amount: NaN
type: Species

metaR FERO
is: SBO:0000176
type: Reaction
product: MODEL1310110054#
reversible: false
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
name: ferroxidase
modifier: MODEL1310110054#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:

http://identifiers.org/biomodels.db/MODEL1310110054#_a229f07e_9c6a_4a9d_a29d_6c74ecd4db30
has only substance units: false
initial amount: NaN
boundary condition: true
name: PIK3C3
is encoded by: hsa:5289
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q8NEB9
type: Species

metaM ksii core2 pre8 g
type: Species
boundary condition: false
notes: FORMULA: C75H121N6O56SX CHARGE: -2
has only substance units: false
is: HMDB00175
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:58053
is: C00130
name: keratan sulfate II biosynthesis, precursor 8

metaM gcald c
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:17071
boundary condition: false
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
constant: false
name: glycolaldehyde
is: HMDB03344

metaM xylu L c
type: Species
name: L-xylulose
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:17399
is: HMDB00751
boundary condition: false

metaR BILIRED
reactant: MODEL1310110054#
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
modifier: MODEL1310110054#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.24
fast: false
product: MODEL1310110054#
name: Nad(p)h biliverdin reductase

metaR r1455
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
kinetic law: MODEL1310110054#
is described by: ECO:0000000
reversible: false
product: MODEL1310110054#
name: Transport reaction
reactant: MODEL1310110054#
type: Reaction

metaR S6T15g
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.8.2.17
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
modifier: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.21
type: Reaction
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD

metaM e4p c
constant: false
name: D-Erythrose 4-phosphate
is: CHEBI:16897
has only substance units: false
is: C00279
type: Species
initial amount: NaN
is: HMDB01321
initial concentration: 1.0
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_2ed32c19_c81f_4873_8081_b74a515229ad
name: _BC005314_1_x
is encoded by: hsa:BC005314
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
type: Species

metaM galgalgalthcrm hs g
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:26174
is: SBO:0000247
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
constant: false
initial amount: NaN

metaR r1456
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
reactant: MODEL1310110054#
reversible: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000185
name: Transport reaction

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaM adpcoa x
type: Species
constant: false
boundary condition: false
has only substance units: false
is: C14143
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
is: SBO:0000247
is: HMDB04047
name: adipoylcoa

http://identifiers.org/biomodels.db/MODEL1310110054#_27fed04a_bd3d_4f13_920d_34df16f276a6
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: PKM2
type: Species
constant: false
boundary condition: true
is encoded by: hsa:5315
initial concentration: NaN

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_955cddae_f07e_445a_a452_42212a595c4f
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
is: O95477
initial amount: NaN
type: Species
is encoded by: hsa:19
name: ABCA1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_271a577f_c1de_4ecc_b863_1ce04fdfc01e
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4645
boundary condition: true
type: Species
is: Q9H6Y6
initial amount: NaN
name: MYO5B
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_14c3e633_c6a1_445e_a1bc_292ab96e9d63
initial concentration: NaN
boundary condition: true
is encoded by: hsa:7915
type: Species
is: Q546H9
name: ALDH5A1
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252

metaR RE3273C
kinetic law: MODEL1310110054#
reversible: true
modifier: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.1.4.4
fast: false
name: RE3273
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
is: SBO:0000176
type: Reaction
reactant: MODEL1310110054#

metaM dgpi prot hs r
initial amount: NaN
is: HMDB06219
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C39H76N4O37P4FULLRCO2FULLR2CO2X CHARGE: 0
type: Species
is: D00348
is: http://identifiers.org/pubchem.compound/7847414
constant: false
boundary condition: false
is: SBO:0000247
name: deacylated-glycophosphatidylinositol (GPI)-anchored protein

metaR DPMVDx
reactant: MODEL1310110054#
name: diphosphomevalonate decarboxylase
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/4.1.1.33
is: SBO:0000176
modifier: MODEL1310110054#
reversible: false
type: Reaction
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.1.33 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ

http://identifiers.org/biomodels.db/MODEL1310110054#_e3c731dc_ee3e_4451_9349_f77dd8e8988a
name: ACO1
is: P21399
constant: false
is encoded by: hsa:48
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true

metaM utp c
name: UTP
is: HMDB00285
constant: false
has only substance units: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:46398
initial concentration: 1.0
is: C00075

http://identifiers.org/biomodels.db/MODEL1310110054#_bfd33559_10b9_4b17_9e91_39e7f28db7a1
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:9152
name: SLC6A5
is: Q9Y345
initial amount: NaN
constant: false

metaM acgbgbside hs c
name: beta GalNAc globoside
initial amount: NaN
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00215
has only substance units: false
is: CHEBI:17411
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_23bd2a24_8149_47aa_82dd_5c5ebb67e7f0
is encoded by: hsa:80864
initial amount: NaN
is: Q99944
name: EGFL8
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_9bde6096_83d3_4075_af4d_055d8b01458c
is encoded by: hsa:2182
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: ACSL4
initial concentration: NaN
boundary condition: true
type: Species
is: O60488
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_e0609690_9b3a_43e2_9639_46bd2bb9a003
is encoded by: hsa:4967
type: Species
initial concentration: NaN
name: DLD:DLST:OGDH:PDHX
initial amount: NaN
is: SBO:0000297
has only substance units: false
constant: false
has part: B4E3E9
boundary condition: true

metaR FAOXC61C4x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_63b203ca_d9b0_4895_ba25_69a70af8677c
is encoded by: hsa:116369
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
name: SLC26A8

http://identifiers.org/biomodels.db/MODEL1310110054#_ab5bb40d_4db2_4ed2_9c27_05cb4b49c081
has only substance units: false
is: SBO:0000252
name: PIGP
type: Species
is: P57054
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:51227
initial amount: NaN

metaR SERCYSNaEx
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110054#
is: SBO:0000185
type: Reaction
name: L-serine/L-cysteine Na-dependent exchange (Ser-L in)
is described by: ECO:0000269
reversible: false

metaR TTDCAFATPc
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaM tymsf c
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
boundary condition: false
has only substance units: false
name: Tyramine O-sulfate
is: HMDB06409
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
initial amount: NaN

metaM ala L m
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00161
name: L-alanine
is: CHEBI:16977
initial concentration: 1.0

metaR SRTNtu
name: Serotonin uniport
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
modifier: MODEL1310110054#
reversible: true
reactant: MODEL1310110054#
fast: false
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_01e466b4_5014_4784_9a10_cf4880de8ae8
is: O75610
has only substance units: false
is encoded by: hsa:10637
boundary condition: true
name: LEFTY1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_b0c9c510_9e7c_4950_80db_2be4359abd7f
is encoded by: hsa:8867
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: C9JFZ1
boundary condition: true
name: SYNJ1
type: Species

metaM ha e
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: hyaluronan
constant: false
has only substance units: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
type: Species
is: CHEBI:16336
initial amount: NaN

metaM dctp n
is: CHEBI:16311
type: Species
initial amount: NaN
name: dCTP
is: C00458
has only substance units: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: HMDB00998
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0

metaM uppg3 c
initial amount: NaN
is: CHEBI:57308
initial concentration: 1.0
boundary condition: false
is: HMDB01086
type: Species
name: Uroporphyrinogen III
notes: FORMULA: C40H36N4O16 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00643 EHMN_ABBREVIATION: C01051
is: C01051
constant: false
has only substance units: false
is: SBO:0000247

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaR DMHPTCRNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES:dmhptcoa is 'special' because its biochemical fat isn't known NJ
is described by: ECO:0000000
name: 2,6 dimethylheptanoyl crn transport
product: MODEL1310110054#
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#

metaM hco3 e
is: C00288
is: HMDB00595
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
boundary condition: false
initial concentration: 1.0
name: Bicarbonate
is: SBO:0000247
initial amount: NaN
is: CHEBI:17544
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_cf7acb98_0c88_4642_bec4_7547e459b82e
boundary condition: true
name: CTPS2
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:56474
is: Q9NRF8
has only substance units: false
constant: false
type: Species

metaR GUMGCHLe
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Binding of guar gums with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaM utp e
initial concentration: 1.0
constant: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:46398
boundary condition: false
is: HMDB00285
name: UTP(4-)

metaR 34DHXMANDACOX NADP
reactant: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
product: MODEL1310110054#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110054#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5

http://identifiers.org/biomodels.db/MODEL1310110054#_9d2599a9_1905_4070_9860_881ec2230b78
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: B4DUY1
constant: false
is encoded by: hsa:10948
name: STARD3

metaM 34dhpha c
boundary condition: false
has only substance units: false
constant: false
is: HMDB01336
is: CHEBI:17612
is: SBO:0000247
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
name: (3,4-dihydroxyphenyl)acetate
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_metaM_galacgalfuc12gal14acglcgalgluside_hs_g
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:26174
boundary condition: false
name: (Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
is: SBO:0000247
notes: FORMULA: C64H112N3O36FULLRCO CHARGE: 0

metaR WHHDCAte
name: xenobiotic transport
kinetic law: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
product: MODEL1310110054#
is: SBO:0000185
fast: false
reactant: MODEL1310110054#
reversible: true

metaR S2TASE2ly
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.13
product: MODEL1310110054#
reversible: false
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
is: SBO:0000176
name: iduronate-2-sulfatase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110054#

metaM ksi deg33 l
is: HMDB00143
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
is: CHEBI:12936
initial concentration: 1.0
type: Species
name: keratan sulfate I, degradation product 33
has only substance units: false

metaR GGH 7DHFe
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
fast: false
name: Gamma-glutamyl hydrolase (7DHF), extracellular
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
modifier: MODEL1310110054#

metaR r1459
is: SBO:0000185
kinetic law: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
is described by: ECO:0000000
name: Transport reaction
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_6165288d_fc0f_4940_a684_0fc56c9d4324
type: Species
is: P18283
initial concentration: NaN
is: SBO:0000252
name: GPX2
boundary condition: true
constant: false
is encoded by: hsa:2877
initial amount: NaN
has only substance units: false

metaM tststerone c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00234
type: Species
has only substance units: false
is: CHEBI:17347
constant: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
name: testosterone
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_1a82b9a8_d8d0_4d30_aab1_f1329f26c48d
has only substance units: false
initial amount: NaN
is: Q9HCR9
boundary condition: true
is encoded by: hsa:50940
initial concentration: NaN
is: SBO:0000252
name: PDE11A
constant: false
type: Species

metaR FAOXC101x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)x
type: Reaction

metaR CORE3GTg
modifier: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
reversible: false
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149

metaR RE0915E
reversible: true
kinetic law: MODEL1310110054#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.17
reactant: MODEL1310110054#
is described by: ECO:0000000
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
type: Reaction
modifier: MODEL1310110054#
name: RE0915
is version of: http://identifiers.org/ec-code/3.2.1.1

http://identifiers.org/biomodels.db/MODEL1310110054#_2df7c4c5_84f7_4606_a900_1d7c4dd09401
initial amount: NaN
is: Q9HAS3
boundary condition: true
is encoded by: hsa:64078
initial concentration: NaN
type: Species
has only substance units: false
constant: false
name: SLC28A3
is: SBO:0000252

metaR CORE4GTg
is version of: http://identifiers.org/ec-code/2.4.1.102
type: Reaction
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
fast: false
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
reactant: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000176

metaM pro L m
is: CHEBI:17203
is: SBO:0000247
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
boundary condition: false
is: HMDB00162
has only substance units: false
constant: false
initial concentration: 1.0
name: L-proline
initial amount: NaN
type: Species

metaR CDSm
reactant: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.41
kinetic law: MODEL1310110054#
fast: false
type: Reaction
is described by: ECO:0000000
name: phosphatidate cytidylyltransferase
product: MODEL1310110054#

metaR FAOXC122x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_b555c797_362b_472b_b811_2f71808f7eee
constant: false
is encoded by: hsa:10317
type: Species
boundary condition: true
name: B3GALT5
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM hLkynr c
boundary condition: false
is: CHEBI:17380
has only substance units: false
is: HMDB11631
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
name: 3-hydroxy-L-kynurenine
constant: false
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227

http://identifiers.org/biomodels.db/MODEL1310110054#_c37246f3_f968_4eb5_9bb1_6f754a2f2ea2
boundary condition: true
name: ND1
has only substance units: false
is encoded by: hsa:4535
is: SBO:0000252
is: Q85KV6
initial concentration: NaN
type: Species
initial amount: NaN
constant: false

metaM dcyt n
initial amount: NaN
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
name: 2'-deoxycytidine
is: HMDB00014
is: SBO:0000247
is: CHEBI:15698
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
has only substance units: false

metaR r0086
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.3
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
modifier: MODEL1310110054#
reversible: false
is: SBO:0000176
product: MODEL1310110054#

metaM pydx c
has only substance units: false
is: HMDB01545
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
name: Pyridoxal
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:17310
is: C00250

metaM atp r
initial concentration: 1.0
is: HMDB00538
is: SBO:0000247
is: C00002
type: Species
is: CHEBI:57299
name: ATP(4-)
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN

metaR S3TASE3ly
fast: false
name: N-acetylglucosamine-3-sulfatase, lysosomal
kinetic law: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110054#

metaR B3GNT35g
kinetic law: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
modifier: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
reversible: false
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110054#_0622b56a_0537_4a50_b4cd_26376dcc8438
is encoded by: hsa:206
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
name: _206_1_c
type: Species

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR DNDPt36m
type: Reaction
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110054#
name: dGDP transport via dCDP antiport
fast: false
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110054#
is described by: ECO:0000269
product: MODEL1310110054#

metaR r2506
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110054#
reversible: true
name: Utilized transport
product: MODEL1310110054#
fast: false
reactant: MODEL1310110054#

metaR LCADi D
reactant: MODEL1310110054#
is: SBO:0000176
type: Reaction
name: lactaldehyde dehydrogenase
fast: false
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
modifier: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.36
is described by: ECO:0000304
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaM gmp e
type: Species
constant: false
name: GMP(3-)
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:58115
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
boundary condition: false
is: SBO:0000247
is: HMDB01397

metaM glutcoa m
boundary condition: false
constant: false
type: Species
is: HMDB01339
name: glutaryl-CoA(5-)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
is: CHEBI:57378
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_1c12333b_80f7_4cc5_b154_4ef3de1bc6a9
is encoded by: hsa:5146
name: PDE6C
initial concentration: NaN
initial amount: NaN
is: P51160
boundary condition: true
type: Species
constant: false
has only substance units: false
is: SBO:0000252

metaR RE1521M
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110054#
name: RE1521
is: SBO:0000176
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110054#_656c264d_e192_4568_9979_fd9a7bfb0567
boundary condition: true
is: Q06520
name: SULT2A1
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:6822

metaR HMGCOASi
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3157.1) or (3157.2) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:1358203 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission Made irreversible to match KEGG data for S. aureus
modifier: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#
reversible: false
type: Reaction
name: Hydroxymethylglutaryl CoA synthase (ir)
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.3.3.10

http://identifiers.org/biomodels.db/MODEL1310110054#_19d19e9a_0a10_4adc_bf2a_d7c464442bb6
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:4830
type: Species
is: SBO:0000252
constant: false
is: P15531
name: NME1

metaM prgstrn e
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410
initial amount: NaN
constant: false
boundary condition: false
is: HMDB01830
is: CHEBI:17026
name: progesterone
is: SBO:0000247
type: Species

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_4745117d_313e_4d69_ba95_8a33ea61f3da
initial concentration: NaN
is encoded by: hsa:8050
is: O00330
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
name: PDHX

metaR FAOXC184C163x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:3)x
type: Reaction

metaR ALDD2xm
product: MODEL1310110054#
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
modifier: MODEL1310110054#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
fast: false
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110054#_c96db657_431d_4e84_954e_a00ff2eda6e3
initial amount: NaN
is: P17050
initial concentration: NaN
is encoded by: hsa:4668
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
name: NAGA
type: Species

metaR S6TASE13ly
product: MODEL1310110054#
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176

metaM pydx e
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
constant: false
name: Pyridoxal
is: CHEBI:17310
initial concentration: 1.0
is: C00250
is: HMDB01545

metaR r1683
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
reversible: false
product: MODEL1310110054#
is: SBO:0000185
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR r0084
is: SBO:0000176
modifier: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.42
fast: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
reversible: true

metaR r2508
reversible: true
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false
reactant: MODEL1310110054#
name: Utilized transport
kinetic law: MODEL1310110054#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaM CE0693 m
constant: false
has only substance units: false
is: CHEBI:28387
type: Species
is: HMDB11123
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
initial concentration: 1.0
boundary condition: false
name: 3-oxolaur-6-cis-enoyl-CoA

metaM utp n
name: UTP(4-)
has only substance units: false
is: HMDB00285
is: CHEBI:46398
initial concentration: 1.0
constant: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false

metaM fgam c
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
initial amount: NaN
is: SBO:0000247
is: HMDB01308
type: Species
is: C04376
is: CHEBI:58426
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false

metaR Asn X Ser Thrtr
product: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
reversible: true
name: Asn-X-Ser/Thr transport (from ER to lysosome)
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110054#

metaR r0085
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
reversible: false
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
fast: false
product: MODEL1310110054#
is: SBO:0000176
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.42

http://identifiers.org/biomodels.db/MODEL1310110054#_78d87a89_36c4_4e8d_bb0d_219900af385a
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:284129
type: Species
is: Q86WA9
is: SBO:0000252
initial amount: NaN
name: SLC26A11

metaM gmp g
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:58115
constant: false
initial concentration: 1.0
name: GMP(3-)
is: HMDB01397
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144

http://identifiers.org/biomodels.db/MODEL1310110054#_fc52a906_4791_4056_9961_386d85cd3c37
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is: B3KXK1
name: SLC26A9
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:115019
constant: false

metaM fuc L c
is: CHEBI:18287
type: Species
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
constant: false
is: HMDB00174
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: L-fucose
has only substance units: false

metaR TDPm
reactant: MODEL1310110054#
fast: false
name: thiamin pyrophosphatase, mitochondrial
product: MODEL1310110054#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 2 AUTHORS: PMID:9755848 NOTES:_01-25-05 IT
reversible: false

metaM udpg c
constant: false
is: CHEBI:58367
name: UDPglucose
type: Species
is: C00029
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00286
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
initial amount: NaN

metaR FAOXC103C102m
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaR 2MCITt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:426765 NOTES:MM
reactant: MODEL1310110054#
name: 2-methylcitrate transport via diffusion
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110054#
product: MODEL1310110054#

metaR NRVNCt
name: fatty acid transport via diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
product: MODEL1310110054#
reversible: true
reactant: MODEL1310110054#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110054#

metaM atp n
initial amount: NaN
type: Species
is: HMDB00538
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
is: CHEBI:57299
name: ATP(3-)
boundary condition: false
is: SBO:0000247

metaR r0082
type: Reaction
is described by: ECO:0000000
product: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
notes: GENE_ASSOCIATION: (2875.1) or (84706.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
reversible: true
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.6.1.2
modifier: MODEL1310110054#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110054#_680845de_0030_4dd8_aad4_7be71a0da9bf
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:34
has only substance units: false
type: Species
is: P11310
name: ACADM

metaR ABUTt2r
type: Reaction
is: SBO:0000185
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000304
reversible: true
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
reactant: MODEL1310110054#
name: 4-aminobutyrate reversible transport in via proton symport
modifier: MODEL1310110054#

metaM T antigen g
initial concentration: 1.0
is: CHEBI:22783
notes: FORMULA: C14H24NO10X CHARGE: 0
constant: false
name: T antigen (core 1)
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR r0840
name: Free diffusion
is version of: http://identifiers.org/ec-code/1.14.13.70
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
product: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110054#
fast: false
modifier: MODEL1310110054#

metaR RE3016R
fast: false
is: SBO:0000176
name: RE3016
is described by: ECO:0000000
reversible: true
product: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9799565,PMID:9862787 NOTES:
kinetic law: MODEL1310110054#

metaR H2Oter
is described by: ECO:0000000
product: MODEL1310110054#
reversible: true
is: SBO:0000185
reactant: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
name: H2O endoplasmic reticulum transport
kinetic law: MODEL1310110054#

metaR LINKDEG4ly
fast: false
type: Reaction
is described by: ECO:0000000
name: degradation of proteoglycan linkage region, lysosomal
reversible: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110054#_eabd33af_294b_448f_b476_be1a8554d336
name: PEMT
has only substance units: false
boundary condition: true
is encoded by: hsa:10400
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN

metaM 7dhchsterol c
is: HMDB00032
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: cholesta-5,7-dien-3beta-ol
is: CHEBI:17759
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164

metaR r0083
is version of: http://identifiers.org/ec-code/1.1.1.42
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
reversible: true
modifier: MODEL1310110054#
product: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
is: SBO:0000176
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
type: Reaction
is described by: ECO:0000000

metaR LEUTAm
reversible: true
fast: false
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
name: leucine transaminase, mitochondrial
type: Reaction
product: MODEL1310110054#
is described by: ECO:0000269
modifier: MODEL1310110054#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.42

metaR RE2985X
notes: GENE_ASSOCIATION: (8310.1) or (8309.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110054#
name: RE2985
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.17.99.3
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
modifier: MODEL1310110054#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110054#
type: Reaction
is: SBO:0000176

metaR r1020
reactant: MODEL1310110054#
type: Reaction
reversible: true
is described by: ECO:0000000
name: Postulated transport reaction
is: SBO:0000185
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
product: MODEL1310110054#
fast: false

metaR r0841
reversible: true
is: SBO:0000185
reactant: MODEL1310110054#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.271
type: Reaction
modifier: MODEL1310110054#
product: MODEL1310110054#
kinetic law: MODEL1310110054#
name: Free diffusion
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:

metaM akg c
has only substance units: false
boundary condition: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: C00026
name: 2-Oxoglutarate
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16810
is: HMDB00208
is: SBO:0000247

metaM hco3 m
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: C00288
boundary condition: false
initial concentration: 1.0
name: Bicarbonate
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB00595
is: CHEBI:17544

metaM fuc L e
name: L-fucose
type: Species
has only substance units: false
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
constant: false
initial amount: NaN
is: HMDB00174
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:18287

metaM sphings c
is: SBO:0000247
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
is: CHEBI:57756
initial amount: NaN
boundary condition: false
name: sphingosine(1+)
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB00252

metaR ALDD21
name: aldehyde dehydrogenase (pristanal, NAD)
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (224.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:8528251 NOTES:NJ
reactant: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#

metaR GLYt2r
reactant: MODEL1310110054#
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
kinetic law: MODEL1310110054#
product: MODEL1310110054#
name: glycine reversible transport via proton symport
is: SBO:0000185
modifier: MODEL1310110054#
fast: false
reversible: true

metaR KHte
name: KHte
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110054#
type: Reaction
is: SBO:0000185
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110054#
reversible: true

metaM hexdiac r
has only substance units: false
name: hexadecanediocacid
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00672
is: C08260
notes: FORMULA: C16H28O4 CHARGE: -2
boundary condition: false
type: Species
is: SBO:0000247

metaM hdcea e
has only substance units: false
type: Species
is: HMDB03229
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:32372
constant: false
name: Hexadecenoate (n-C16:1)
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_2008dcc0_643c_4af8_bcf5_18d547344d29
is: SBO:0000252
has only substance units: false
is: Q16773
initial concentration: NaN
type: Species
initial amount: NaN
name: CCBL1
constant: false
is encoded by: hsa:883
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_a4f41596_9e31_4a12_b37c_2bd74fcbf791
name: GOT1
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2805
constant: false
is: SBO:0000252
is: P17174
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_54d4ff68_c7fa_49b1_a048_6d85e0f63e2c
type: Species
initial amount: NaN
is encoded by: hsa:64064
constant: false
name: OXCT2
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q9BYC2

metaR r0842
is version of: http://identifiers.org/ec-code/1.3.1.72
product: MODEL1310110054#
fast: false
is described by: ECO:0000000
name: Postulated transport reaction
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_81c8f392_ecbc_45ca_b835_a9c2de975f92
boundary condition: true
has only substance units: false
is encoded by: hsa:6547
is: B3KU59
initial concentration: NaN
is: SBO:0000252
name: SLC8A3
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_be58257c_6302_4a43_86f9_c194c6e1a6e4
is encoded by: hsa:AI971036
has only substance units: false
initial amount: NaN
type: Species
name: _AI971036_1_c
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_e625a678_dad7_4da2_999b_24c6cd912a37
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
name: SULT1A1
is encoded by: hsa:6817

http://identifiers.org/biomodels.db/MODEL1310110054#_3837af38_1f4a_4fb6_86a5_f861004ca997
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:84720
constant: false
is: SBO:0000252
name: PIGO
initial amount: NaN
boundary condition: true

metaM glu5p m
type: Species
notes: FORMULA: C5H8NO7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01092 EHMN_ABBREVIATION: C03287
is: SBO:0000247
initial concentration: 1.0
name: L-Glutamate 5-phosphate
has only substance units: false
is: CHEBI:58274
initial amount: NaN
is: HMDB01228
constant: false
boundary condition: false

metaR r0295
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
reversible: false
reactant: MODEL1310110054#
is: SBO:0000176
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
type: Reaction

metaR H2MTer U
modifier: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
kinetic law: MODEL1310110054#
fast: false
is: SBO:0000176
name: H2 mannosyltransferase, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110054#_99b0191c_3bbe_4a53_8cf3_e89846de92e6
name: SLC25A20
is: O43772
constant: false
is encoded by: hsa:788
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species

metaR r0081
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
fast: false
product: MODEL1310110054#
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
is version of: http://identifiers.org/ec-code/1.5.1.12
reversible: true
is: SBO:0000176

metaR r0497
modifier: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.4.2
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
reversible: true
kinetic law: MODEL1310110054#
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
is described by: ECO:0000000
product: MODEL1310110054#
reactant: MODEL1310110054#

metaM mercplaccys c
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB06512
name: 3-mercaptolactate-cysteine disulfide
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_14d9a8da_33bd_46f6_b60b_9202ff60d234
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:80025
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
name: PANK2

metaR r0191
fast: false
modifier: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
reversible: false
reactant: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.24
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11

metaM Rtotal3coa c
boundary condition: false
is: HMDB01448
initial amount: NaN
is: CHEBI:16189
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: R total 3 Coenzyme A

metaM ksii core4 pre1 g
name: keratan sulfate II biosynthesis, precursor 1
constant: false
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C36H60N3O25X CHARGE: 0
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28067

http://identifiers.org/biomodels.db/MODEL1310110054#_93a7eb6f_a20c_4f2c_a1a4_894c9e658380
is encoded by: hsa:27068
constant: false
name: PPA2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true

metaM gpi prot hs r
has only substance units: false
initial amount: NaN
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2X CHARGE: 0
is: SBO:0000247
is: HMDB00220
constant: false
type: Species
is: CHEBI:7896
is: C00249
boundary condition: false
initial concentration: 1.0
name: {[(Prot-PE-Man),(PE)-Man],[PE]}-Man-GlcN-acylPI

metaM gln L c
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
initial concentration: 1.0
is: CHEBI:18050
is: SBO:0000247
type: Species
is: HMDB00641
name: L-glutamine
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_90086c96_4200_4a9b_bf5f_617edb5959a2
name: ACADVL
is: P49748
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:37
is: SBO:0000252

metaM 3hpp m
is: SBO:0000247
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
is: HMDB00700
constant: false
boundary condition: false
type: Species
name: 3-hydroxypropionate
is: CHEBI:16510
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR r0494
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
is described by: ECO:0000000
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reversible: true
reactant: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176
fast: false

metaR ANTHte
reversible: true
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reactant: MODEL1310110054#
type: Reaction
name: Transport of anthranilate

metaR FAOXC14C12x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

metaR CYSASNNaEx
reversible: false
modifier: MODEL1310110054#
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
fast: false
product: MODEL1310110054#
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_be251036_b6cc_4868_b650_fc6f65f7b3c4
constant: false
type: Species
initial amount: NaN
name: CA3
is encoded by: hsa:761
has only substance units: false
boundary condition: true
is: P07451
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_b3c1d60e_0267_41d4_9df7_9049cae30758
initial concentration: NaN
is encoded by: hsa:158
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
name: ADSL

metaR r1797
name: Y+LAT2 Utilized transport
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110054#
modifier: MODEL1310110054#
reversible: false
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false

metaR PTE3x
reactant: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
modifier: MODEL1310110054#
reversible: false
kinetic law: MODEL1310110054#
fast: false
product: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.2
name: peroxisomal acyl-CoA thioesterase

metaR FAOXC103C102x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_b01b1d1e_006a_4655_ad5c_02b8f8956d4b
type: Species
is encoded by: hsa:4715
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q9Y6M9
is: SBO:0000252
name: NDUFB9
constant: false

metaM ksi deg14 l
boundary condition: false
constant: false
type: Species
name: keratan sulfate I, degradation product 14
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00143
is: SBO:0000247
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110054#_5626434c_02b8_4f77_a56f_0f0d35f9e7e8
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: P19174
is: SBO:0000252
is encoded by: hsa:5335
name: PLCG1
type: Species
constant: false
has only substance units: false

metaM gln L e
is: CHEBI:18050
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: HMDB00641
type: Species
constant: false
initial amount: NaN
name: L-glutamine
boundary condition: false

metaR G14T20g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
is described by: ECO:0000000
product: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_51bb27da_b147_4c2c_9bac_1d7ca5ff6872
is: SBO:0000252
is encoded by: hsa:6536
boundary condition: true
initial amount: NaN
name: SLC6A9
type: Species
initial concentration: NaN
is: P48067
constant: false
has only substance units: false

metaM gmp n
name: GMP(3-)
has only substance units: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
boundary condition: false
initial concentration: 1.0
is: HMDB01397
type: Species
is: CHEBI:58115
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_13fd66e6_b14a_42f4_945f_36054988393a
constant: false
name: TUSC3
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:7991
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM zymstnl r
name: 5alpha-cholest-8-en-3beta-ol
is: HMDB06841
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
initial concentration: 1.0
boundary condition: false
is: CHEBI:16608
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_5b75c1c5_1252_42c2_9018_5590aa2ff651
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q9UBF8
is: SBO:0000252
name: PI4KB
initial concentration: NaN
type: Species
is encoded by: hsa:5298

http://identifiers.org/biomodels.db/MODEL1310110054#_d20f5697_103c_4e1f_b698_19b96e884b6c
has only substance units: false
constant: false
type: Species
name: PDE9A
initial amount: NaN
is encoded by: hsa:5152
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_fc0d15d6_487a_403f_a9e0_5e156b38b9a3
has only substance units: false
name: BCKDHB
boundary condition: true
is encoded by: hsa:594
is: P21953
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
type: Species

metaM hdcea r
is: CHEBI:32372
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB03229
name: palmitoleate

metaM b2coa m
has only substance units: false
is: HMDB02009
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:57332
is: SBO:0000247
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
name: crotonoyl-CoA(4-)
type: Species
boundary condition: false

metaM 4abutn m
initial concentration: 1.0
name: 4-ammoniobutanal
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:58264
boundary condition: false
constant: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
initial amount: NaN
is: HMDB01080

http://identifiers.org/biomodels.db/MODEL1310110054#_e5706b90_c2a3_4c9b_8455_48a40dddf8b5
is: Q01581
name: HMGCS1
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:3157

metaR EX prgstrn LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Progesterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_933aeee0_681e_40a2_a7c6_6e8eab948ab5
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
name: ACE
is: B4DKH4
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1636

metaR S6T4g
type: Reaction
kinetic law: MODEL1310110054#
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_a476bc4f_c1d4_47d0_ae63_ab6d678912d1
type: Species
constant: false
name: PGM3
is: B4DX94
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5238
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_fc0e73f9_2994_4016_b3f7_c8e358f1d60f
name: ALDH1B1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:219
boundary condition: true
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: P30837

http://identifiers.org/biomodels.db/MODEL1310110054#_3391d024_f5ff_4825_9ddc_a78520bbe906
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: DGKD
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:8527

http://identifiers.org/biomodels.db/MODEL1310110054#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_g
is: HMDB00304
type: Species
has only substance units: false
name: Type IIIA glycolipid
constant: false
is: CHEBI:57847
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_37aee7cd_6e68_42b7_bd2a_731aa1fd80cd
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:5140
is: SBO:0000252
initial concentration: NaN
constant: false
is: A7E2E5
name: PDE3B

metaM g2m8mpdol L r
initial amount: NaN
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: CHEBI:59093
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C1900H3128N20O720P20 CHARGE: -20
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_f47f894d_2fc6_4dca_b5ba_0197bb1850f8
initial amount: NaN
is: SBO:0000252
is: Q8N3E9
boundary condition: true
constant: false
is encoded by: hsa:113026
name: PLCD3
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_7b1c91e2_c02b_481d_856a_20255c43ff35
type: Species
has only substance units: false
is: Q16836
is encoded by: hsa:3033
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: HADH
constant: false
initial amount: NaN

metaR r2131
is described by: ECO:0000000
product: MODEL1310110054#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
modifier: MODEL1310110054#

metaR DMNONCOACRNCPT1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
reversible: true
kinetic law: MODEL1310110054#
name: DMNONCOACRNCPT1
fast: false
reactant: MODEL1310110054#
is: SBO:0000176
type: Reaction
product: MODEL1310110054#

metaM fuc L l
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00174
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
is: CHEBI:18287
has only substance units: false
name: L-fucose

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaR NRPPHRSFt
name: norepinephrine sulfate transport (diffusion)
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_50d31714_eb1a_4ff6_befb_748757aa9fe0
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5291
name: PIK3CB
initial amount: NaN
is: SBO:0000252
constant: false
is: B4DER4
type: Species
has only substance units: false

metaM cs b deg2 l
is: HMDB00812
initial amount: NaN
notes: FORMULA: C37H54NO41S3 CHARGE: -5
is: CHEBI:16953
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
type: Species
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
initial concentration: 1.0

metaR r2509
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110054#
fast: false
is described by: ECO:0000000
type: Reaction
name: Utilized transport
reversible: true
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000185

metaM prgstrn c
initial amount: NaN
is: CHEBI:17026
constant: false
is: SBO:0000247
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410
name: progesterone
is: HMDB01830
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false

metaR r1680
product: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
modifier: MODEL1310110054#
reversible: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110054#

metaR r0196
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
reversible: true
is: SBO:0000176
fast: false
reactant: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.6.1.5
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37

metaM ei11ecoa x
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
is: SBO:0000247
name: 11-eicosenoylcoa

metaR UREAt5
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:NCD
fast: false
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110054#
modifier: MODEL1310110054#
is described by: ECO:0000269
name: urea, water cotransport
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#

metaR r2132
reactant: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110054#
fast: false
product: MODEL1310110054#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

metaR 34HPPte
is: SBO:0000185
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110054#
name: Transport of 3-(4-hydroxyphenyl)pyruvate
kinetic law: MODEL1310110054#
fast: false
product: MODEL1310110054#

metaM chlstol r
constant: false
type: Species
is: HMDB06842
name: 5alpha-cholesta-7,24-dien-3beta-ol
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:16290
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439

http://identifiers.org/biomodels.db/MODEL1310110054#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_e
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
is: HMDB01659
name: Type IIIA glycolipid
type: Species
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15347
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_4682d2d5_2932_4c3d_be4e_7848a793c3b0
is encoded by: hsa:8875
boundary condition: true
name: VNN3:VNN2:VNN1
initial amount: NaN
is encoded by: hsa:8876
type: Species
constant: false
is: SBO:0000297
has part: A8K7W0
has only substance units: false
has part: O95497
initial concentration: NaN
is encoded by: hsa:55350

metaR SIAASE4ly
modifier: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000000
reactant: MODEL1310110054#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110054#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
type: Reaction

metaR r0193
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110054#
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1

metaR MECOAS1m
product: MODEL1310110054#
reversible: true
reactant: MODEL1310110054#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000304
name: mesaconate--CoA ligase (GDP-forming)
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_b710af00_ecaa_4747_9579_12863a3e24ec
boundary condition: true
type: Species
is: Q9Y2A9
is encoded by: hsa:10331
name: B3GNT3
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false

metaM HC00319 m
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
boundary condition: false
name: Malonate
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:30794
constant: false

metaR FADH2ETC
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
name: Complex II reaction for respiratory chain
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000134

metaM sphings l
initial amount: NaN
is: CHEBI:57756
is: HMDB00252
constant: false
is: SBO:0000247
name: sphingosine(1+)
type: Species
has only substance units: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_8375f9a6_c3ed_40db_b358_54353a2406b7
initial amount: NaN
name: NME1:NME2
constant: false
has part: P15531
is encoded by: hsa:4830
has part: P22392
initial concentration: NaN
is: SBO:0000297
has only substance units: false
boundary condition: true
is encoded by: hsa:4831
type: Species

metaR FAOXC165C164x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:5-->C16:4)x
type: Reaction

metaM dolp U c
type: Species
boundary condition: false
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: CHEBI:57683
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: dolichyl phosphate(2-)

metaM atp x
has only substance units: false
name: ATP(4-)
type: Species
initial concentration: 1.0
is: HMDB00538
is: CHEBI:57299
is: SBO:0000247
initial amount: NaN
constant: false
is: C00002
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_288d821b_13c7_46b9_a35d_e6d6cf50347c
initial amount: NaN
boundary condition: true
is: P24298
is: SBO:0000252
name: GPT
type: Species
is encoded by: hsa:2875
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_91a0f847_cac4_4d1f_b142_695c3329eced
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q96NT5
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:113235
name: SLC46A1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_edd0806a_2e4f_4247_8e82_ed9d851d66fa
name: DPM2
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8818
is: SBO:0000252

metaR DNDPt25m
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110054#
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110054#
name: dTDP transport via dCDP antiport
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110054#

metaR ABO9g
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
fast: false
is described by: ECO:0000269
modifier: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
reactant: MODEL1310110054#
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
kinetic law: MODEL1310110054#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.37
is: SBO:0000176

metaR CLPNDCOAtx
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
product: MODEL1310110054#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
is described by: ECO:0000000
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_f0b2f881_79a9_4c41_87a3_8252219c2570
name: PLCB4
type: Species
is encoded by: hsa:5332
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is: Q15147
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_5df8499a_27ac_45d1_a935_e8763859be34
is: E7EUT4
type: Species
initial amount: NaN
is encoded by: hsa:2597
constant: false
name: GAPDH
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_e2cc270e_b437_4c63_bd42_6d995599a63e
type: Species
name: _U37519_1_c
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:U37519
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR GLCter
is described by: ECO:0000000
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
reversible: true
name: glucose transport, endoplasmic reticulum
is: SBO:0000185
type: Reaction
product: MODEL1310110054#
fast: false

metaR 13DAMPPOX
kinetic law: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
is version of: http://identifiers.org/ec-code/1.4.3.21
reactant: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.22
is described by: ECO:0000212
reversible: false
is: SBO:0000176

metaR r2130
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110054#
reversible: true
fast: false

metaR AG13T12g
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110054#
reversible: false
fast: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110054#
product: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110054#_12374ce1_667e_40b0_a772_e92fcaf3fcf6
is: Q16850
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: CYP51A1
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1595
type: Species

metaR ILEt5m
type: Reaction
product: MODEL1310110054#
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
name: Isoleucine mitochondrial transport
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaM adrncoa x
is: http://identifiers.org/pubchem.compound/47205480
boundary condition: false
initial concentration: 1.0
name: adrenyl coenzyme A
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: C16170
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
type: Species

metaR A MANASEly
type: Reaction
kinetic law: MODEL1310110054#
product: MODEL1310110054#
modifier: MODEL1310110054#
is described by: ECO:0000000
name: alpha-mannosidase, lysosomal
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.24
is: SBO:0000176
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD

metaM gly x
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
name: glycine
initial concentration: 1.0
is: HMDB00123
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:15428
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_e940407c_44de_4d1c_9d25_cae6b6e82281
constant: false
initial concentration: NaN
name: ABCB4
has only substance units: false
is: P21439
is encoded by: hsa:5244
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_c
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: Type IIIA glycolipid
boundary condition: false
is: HMDB01659
type: Species
constant: false
is: CHEBI:15347

http://identifiers.org/biomodels.db/MODEL1310110054#_f8a86052_018e_432b_86dd_3fa7375631e5
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
name: SLC38A1
is encoded by: hsa:81539
is: Q9H2H9
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_01702160_34e6_41f5_aa4d_73c587f161c7
type: Species
is encoded by: hsa:4715
boundary condition: true
name: NDUFB9
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is: Q9Y6M9

metaR CITRtm
type: Reaction
name: citrulline mitochondrial transport via proton antiport
is: SBO:0000185
reversible: true
is described by: ECO:0000269
product: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110054#
fast: false

metaR r1579
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110054#
reversible: true
fast: false
is described by: ECO:0000000

metaM retinol cis 11 c
type: Species
is: CHEBI:16302
name: 11-cis-retinol
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
has only substance units: false
is: HMDB06216
initial amount: NaN
initial concentration: 1.0

metaM chsterol m
is: HMDB00067
type: Species
is: CHEBI:16113
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: cholesterol
has only substance units: false
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: SBO:0000247

metaM HC01609 e
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:28766
type: Species
boundary condition: false
name: UroporphyrinogenI

metaR AG13T11g
product: MODEL1310110054#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110054#
fast: false

metaM gdp c
has only substance units: false
boundary condition: false
is: CHEBI:58189
type: Species
constant: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial concentration: 1.0
is: SBO:0000247
is: HMDB01201
name: GDP
initial amount: NaN
is: C00035

http://identifiers.org/biomodels.db/MODEL1310110054#_d3547924_2212_4ce9_8455_31ffc232bd5a
type: Species
has only substance units: false
is: Q8TEQ8
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:84720
is: SBO:0000252
name: PIGO
boundary condition: true

metaR r2124
modifier: MODEL1310110054#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110054#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110054#
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_203ce259_07fa_431b_945a_fd1c543cf027
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: LGSN
constant: false
initial amount: NaN
is: Q5TDP6
is encoded by: hsa:51557
boundary condition: true

metaM 4abutn c
is: CHEBI:58264
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: C00555
is: HMDB01080
name: 4-Aminobutanal
type: Species
constant: false
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555

metaR GLUTCOADHm
name: glutaryl-CoA dehydrogenase (mitochondria)
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000304
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.7
reversible: false
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
is: SBO:0000176

metaM dgmp m
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: CHEBI:57673
name: dGMP
boundary condition: false
is: C00362
is: HMDB01044
initial concentration: 1.0
constant: false

metaR RE1709N
kinetic law: MODEL1310110054#
is described by: ECO:0000000
modifier: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.96
reactant: MODEL1310110054#
name: RE1709
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110054#_cbdf907c_df8d_4b7c_8dff_a0758e7ddbf5
has only substance units: false
is: E7EQF2
name: CROT
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:54677
constant: false

metaR C4STMO2r
is version of: http://identifiers.org/ec-code/1.14.13.72
kinetic law: MODEL1310110054#
name: C-4 methyl sterol oxidase
fast: false
reactant: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.170
type: Reaction
modifier: MODEL1310110054#

metaR PPCOAOm
is: SBO:0000176
modifier: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
reversible: false
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000269
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
is version of: http://identifiers.org/ec-code/1.3.8.1

metaR LDH D
is: SBO:0000176
type: Reaction
reactant: MODEL1310110054#
fast: false
modifier: MODEL1310110054#
is described by: ECO:0000304
reversible: true
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.1.2.4
kinetic law: MODEL1310110054#
name: D-lactate dehydrogenase

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_067e78e6_0e0a_453e_b2e0_df4b0e3b115a
is: SBO:0000252
type: Species
is: P12074
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1337
has only substance units: false
name: COX6A1
boundary condition: true
constant: false

metaR NACHEX11ly
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176
reversible: false

metaR 3MOPt2im
is: SBO:0000185
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
is described by: ECO:0000000
reversible: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
kinetic law: MODEL1310110054#
type: Reaction
fast: false
reactant: MODEL1310110054#

metaR r2123
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110054#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
modifier: MODEL1310110054#
is described by: ECO:0000000

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaM pail45p hs m
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
has only substance units: false
name: phosphatidylinositol 4,5-bisphosphate
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:28910

metaR RE0926E
is described by: ECO:0000000
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110054#
is: SBO:0000176
fast: false
name: RE0926
reversible: true
type: Reaction
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.1

metaR RE2655R
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110054#
is: SBO:0000176
name: RE2655
fast: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:

metaR EX pydx5p LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of pyridoxal 5-phosphate(2-)
type: Reaction

metaR 4HGLSDm
is described by: ECO:0000212
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.5.1.12
fast: false
product: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#

metaR r2122
modifier: MODEL1310110054#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110054#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110054#
is: SBO:0000185
product: MODEL1310110054#

metaR NAGA2ly
name: N-acetylgalactosaminidase, alpha-
is: SBO:0000176
product: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.49
reversible: false
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
is described by: ECO:0000000
modifier: MODEL1310110054#

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_c6132410_f157_4f50_b3be_65594c0f48e9
is encoded by: hsa:114799
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
name: ESCO1
has only substance units: false
initial concentration: NaN
is: Q5FWF5
type: Species

metaR r0186
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
is: SBO:0000176
reversible: false
type: Reaction
modifier: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110054#_37957aa1_c0f1_482d_870f_1de9033702fd
is encoded by: hsa:54872
is: SBO:0000297
initial amount: NaN
constant: false
name: PIGF:PIGG
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
has part: Q8NCI4

metaR RE3272N
fast: false
reversible: true
is: SBO:0000176
name: RE3272
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:

metaR r1578
reversible: true
product: MODEL1310110054#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
is described by: ECO:0000000

metaM sgalside hs l
has only substance units: false
is: CHEBI:16349
type: Species
is: HMDB00904
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
name: sulfatide galactocerebroside

metaR r2121
reversible: true
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
is: SBO:0000185
product: MODEL1310110054#
modifier: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_0f6ebfdf_ab4c_424d_9605_67d5c8bfe4ce
is: SBO:0000252
is: O60476
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
name: MAN1A2
is encoded by: hsa:10905

metaM hestratriol r
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
is: HMDB05896
type: Species
name: 4,17 dihydroxy estradiol
constant: false

metaR r1879
kinetic law: MODEL1310110054#
fast: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
reactant: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110054#
reversible: false
product: MODEL1310110054#

metaR r2128
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110054#
fast: false
is: SBO:0000185
modifier: MODEL1310110054#
reversible: true
type: Reaction
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110054#

metaM 1p3h5c c
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: SBO:0000247
is: HMDB01369
initial concentration: 1.0
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
type: Species
initial amount: NaN
is: CHEBI:6151
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_94e9c2eb_e81e_4503_97de_7d90fe4f8f53
boundary condition: true
is: SBO:0000252
constant: false
name: NDUFA1
has only substance units: false
is encoded by: hsa:4694
initial concentration: NaN
type: Species
is: Q6IBB5
initial amount: NaN

metaR DCMPDA
modifier: MODEL1310110054#
is described by: ECO:0000254
product: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
fast: false
is: SBO:0000176
reversible: true
type: Reaction
name: dCMP deaminase
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.5.4.12

metaM ksi deg2 l
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB02177
name: keratan sulfate I, degradation product 2
notes: FORMULA: C241H384N17O210S12 CHARGE: -13
is: CHEBI:36033
boundary condition: false

metaM gdp g
initial concentration: 1.0
name: GDP(3-)
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
constant: false
type: Species
is: HMDB01201
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:58189

metaR r1575
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110054#
type: Reaction
fast: false
product: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110054#_c9cf0f68_6966_44b7_9dcc_d5a73293b82f
boundary condition: true
is: B3KQV3
constant: false
is encoded by: hsa:79837
name: PIP4K2C
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_97fbcf6d_e79c_49b2_ae2f_bc92ddd253ca
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
name: PYCR1
initial amount: NaN
initial concentration: NaN
is: A6NFM2
is encoded by: hsa:5831
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_7e4e5d3d_1243_43b1_85df_a9e744c62a83
constant: false
is encoded by: hsa:27306
initial concentration: NaN
has only substance units: false
name: HPGDS
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: O60760
type: Species

metaM hom L c
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial concentration: 1.0
name: L-homoserine
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:15699
has only substance units: false
constant: false
is: HMDB00719
boundary condition: false

metaR r2127
fast: false
is: SBO:0000185
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110054#
modifier: MODEL1310110054#
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110054#

metaR r1576
reactant: MODEL1310110054#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110054#
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_0b19abde_c75b_4b31_b010_bbee2c4e53d9
is: SBO:0000252
name: LDHAL6B
initial amount: NaN
boundary condition: true
is: Q9BYZ2
is encoded by: hsa:92483
has only substance units: false
type: Species
constant: false
initial concentration: NaN

metaM chsterol r
constant: false
boundary condition: false
type: Species
name: cholesterol
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:16113
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: HMDB00067
initial amount: NaN

metaR FAOXC205C184x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:4)x
type: Reaction

metaM ksi pre1 g
boundary condition: false
constant: false
name: keratan sulfate I biosynthesis, precursor 1
is: CHEBI:58053
initial amount: NaN
initial concentration: 1.0
type: Species
is: C00130
is: HMDB00175
has only substance units: false
notes: FORMULA: C79H129N5O57X CHARGE: -1
is: SBO:0000247

metaR r1873
reversible: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110054#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110054#
fast: false

metaM gdp e
name: GDP(3-)
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
type: Species
constant: false
is: HMDB01201
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:58189
is: SBO:0000247
initial concentration: 1.0

metaM retinol cis 11 e
name: 11-cis-retinol
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
type: Species
is: CHEBI:16302
is: HMDB06216
has only substance units: false

metaM amet c
is: C00019
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB01185
boundary condition: false
initial amount: NaN
name: S-Adenosyl-L-methionine
initial concentration: 1.0
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: CHEBI:15414

http://identifiers.org/biomodels.db/MODEL1310110054#_3e82fe02_b5fa_4035_a175_38741552eeed
is: SBO:0000252
initial amount: NaN
is: O15254
has only substance units: false
initial concentration: NaN
name: ACOX3
constant: false
is encoded by: hsa:8310
boundary condition: true
type: Species

metaM s2l2n2m2masn e
constant: false
initial amount: NaN
is: C00255
is: CHEBI:3554
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: de-Fuc form of PA6
boundary condition: false
is: HMDB00244
notes: FORMULA: C84H135N6O61X CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110054#_c2157ba4_b1f0_4417_aeab_dff22dd42fdf
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:11001
type: Species
is: SBO:0000252
initial amount: NaN
is: O14975
name: SLC27A2
constant: false

metaR r2126
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
fast: false
reactant: MODEL1310110054#
is: SBO:0000185
type: Reaction
product: MODEL1310110054#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110054#_7a74643a_3d84_4aa4_a288_a73510cda085
is: SBO:0000252
name: GALT
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:2592
type: Species
initial amount: NaN
has only substance units: false
is: B2RAT6

metaR RE2079R
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reversible: true
fast: false
product: MODEL1310110054#
reactant: MODEL1310110054#
name: RE2079

metaM HC01444 e
boundary condition: false
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
is: CHEBI:15754
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: Galactosylglycerol
initial amount: NaN

metaM pail45p hs n
has only substance units: false
initial concentration: 1.0
is: CHEBI:28910
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
constant: false
initial amount: NaN
name: phosphatidylinositol 4,5-bisphosphate
is: SBO:0000247
boundary condition: false

metaR r1573
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_84cc47ac_832c_4601_83fe_27a2b1b46649
initial concentration: NaN
name: ACAA2
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:10449
initial amount: NaN
is: P42765
constant: false
boundary condition: true

metaM HC01408 m
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
name: 3-Oxohexanoyl-CoA
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
type: Species
is: CHEBI:27648
is: SBO:0000247

metaR OXAHCOtex
product: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
fast: false
name: oxalate transport via bicarbonate countertransport
is: SBO:0000185
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (1836.1) or (10861.1) or (10861.3) or (10861.2) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is described by: ECO:0000304
reversible: false

metaR PHCDm
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
is version of: http://identifiers.org/ec-code/1.5.1.12
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
product: MODEL1310110054#
modifier: MODEL1310110054#
is described by: ECO:0000304
reversible: false
is: SBO:0000176
fast: false

metaM 7dhchsterol r
initial concentration: 1.0
initial amount: NaN
name: cholesta-5,7-dien-3beta-ol
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00032
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
type: Species
is: CHEBI:17759

metaR r2125
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110054#
is: SBO:0000185
modifier: MODEL1310110054#
product: MODEL1310110054#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction

metaR FMNAT
reactant: MODEL1310110054#
type: Reaction
fast: false
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.7.2
is described by: ECO:0000134
kinetic law: MODEL1310110054#
name: FMN adenylyltransferase
is: SBO:0000176
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
modifier: MODEL1310110054#
reversible: false

metaR EX doco13ac
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_c54bb548_0b35_4d1a_9e85_5fa3f96f6bf5
is encoded by: hsa:2539
is: SBO:0000252
is: P11413
has only substance units: false
name: G6PD
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_fc1814ce_ec97_4b9e_bbba_e8b40a1d731c
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4124
is: SBO:0000252
name: MAN2A1
has only substance units: false
type: Species
constant: false
is: Q16706

metaR r1574
product: MODEL1310110054#
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110054#_da274471_9a56_43c1_b4ba_fb0aeea84291
initial amount: NaN
has only substance units: false
name: ATP5D
type: Species
is: SBO:0000252
is encoded by: hsa:513
is: P30049
constant: false
initial concentration: NaN
boundary condition: true

metaM mercplaccys e
initial concentration: 1.0
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
constant: false
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB06512
name: 3-mercaptolactate-cysteine disulfide

metaR XOLTRIOLtm
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
reversible: true
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110054#

metaM HC00718 c
initial amount: NaN
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
type: Species
name: N-methylethanolaminium phosphate(1-)
is: CHEBI:57781
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247

metaM hom L e
has only substance units: false
is: HMDB00719
is: CHEBI:15699
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
name: L-homoserine

metaM q10h2 c
initial amount: NaN
type: Species
has only substance units: false
constant: false
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: SBO:0000247
name: Ubiquinol-10
boundary condition: false
is: http://identifiers.org/pubchem.compound/6504740
initial concentration: 1.0
is: HMDB13111

metaM mi1p D c
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB02985
boundary condition: false
constant: false
initial concentration: 1.0
name: 1D-myo-inositol 1-phosphate(2-)
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
is: CHEBI:58433

metaM HC00822 l
boundary condition: false
is: SBO:0000247
name: Chitobiose
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:28681
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674

metaR r1571
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000185

metaR MI14Ptn
name: inositol 1,4-bisphosphate nuclear transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110054#
fast: false

metaR r0627
product: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
type: Reaction
reactant: MODEL1310110054#
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000000
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23

metaM pail45p hs c
name: phosphatidylinositol 4,5-bisphosphate
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: SBO:0000247
is: CHEBI:28910

metaR r1466
name: EC:2.3.1.86
is described by: ECO:0000000
kinetic law: MODEL1310110054#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110054#
reactant: MODEL1310110054#
reversible: true
fast: false

metaR B MANNASEly
name: beta-mannosidase, lysosomal
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.25
reversible: false
product: MODEL1310110054#

metaR RETH
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.1.1.3
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
reversible: false
fast: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT
name: retinyl ester hydrolase
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110054#_0230da2e_9a42_4fce_9536_8405f751c912
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:8501
is: O75387
type: Species
name: SLC43A1
initial amount: NaN
is: SBO:0000252
constant: false

metaM hs deg7 l
type: Species
constant: false
initial concentration: 1.0
is: HMDB01352
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
name: heparan sulfate, degradation product 7
has only substance units: false
is: CHEBI:17180
boundary condition: false

metaR VLCSr
type: Reaction
fast: false
modifier: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: Very-long-chain-fatty-acid-CoA ligase
is: SBO:0000176
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
reversible: false
is described by: ECO:0000269

metaR M13N2Tg
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.1.101
modifier: MODEL1310110054#
is: SBO:0000176
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
reversible: false
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110054#
type: Reaction

metaR r1467
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reversible: true
name: Postulated transport reaction
reactant: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaR TPI
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
reversible: true
name: triose-phosphate isomerase
product: MODEL1310110054#
modifier: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/5.3.1.1
is described by: ECO:0000134

metaR S6TASE24ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14

metaM ddcacoa c
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
has only substance units: false
type: Species
is: SBO:0000247
constant: false
is: C01832
boundary condition: false
initial amount: NaN
is: HMDB03571
name: Dodecanoyl-CoA (n-C12:0CoA)
is: CHEBI:57375
initial concentration: 1.0

metaM dgmp e
constant: false
initial concentration: 1.0
name: dGMP(2-)
is: CHEBI:57673
has only substance units: false
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: HMDB01044
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_d8dd82b5_81f5_4904_82c5_cfdecc3d80ec
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: PSAT1
is encoded by: hsa:29968
initial concentration: NaN
boundary condition: true
constant: false

metaM chsterol e
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00067
name: cholesterol
is: CHEBI:16113
type: Species

metaR GALASE14ly
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110054#
modifier: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110054#
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_b9d3c83f_3b6a_4172_93be_5ee519e91818
initial amount: NaN
initial concentration: NaN
name: HEXB
has only substance units: false
is encoded by: hsa:3074
boundary condition: true
type: Species
constant: false
is: P07686
is: SBO:0000252

metaR SPMTDe
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
fast: false
name: SPMTDe

http://identifiers.org/biomodels.db/MODEL1310110054#_ed48a4c0_6d1d_497f_a0b3_1662e17670e3
initial concentration: NaN
name: PIK3R2
boundary condition: true
is: O00459
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:5296
type: Species

metaM retfa c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:50211
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
has only substance units: false
boundary condition: false
name: fatty acid retinol
is: HMDB00305

metaM focytC m
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:16928
type: Species
name: Ferrocytochrome C
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM q10h2 e
initial concentration: 1.0
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
type: Species
constant: false
is: SBO:0000247
has only substance units: false
name: Ubiquinol-10
is: http://identifiers.org/pubchem.compound/6504740
boundary condition: false
is: HMDB13111
initial amount: NaN

metaR r1464
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
name: Active transport
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110054#

metaR r0629
type: Reaction
reactant: MODEL1310110054#
product: MODEL1310110054#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
kinetic law: MODEL1310110054#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.1
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
fast: false
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.6.1.22

metaM mthgxl c
name: methylglyoxal
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: CHEBI:17158
initial concentration: 1.0
is: HMDB01167
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546

metaR RE1898C
product: MODEL1310110054#
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110054#
name: RE1898
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
reactant: MODEL1310110054#
reversible: true

metaM dcyt c
name: Deoxycytidine
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:15698
is: HMDB00014
is: C00881
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_9a7c8a7a_42c8_4522_a58f_d2cfc9ee934a
initial amount: NaN
is: SBO:0000252
is: A8K3L7
name: CDIPT
initial concentration: NaN
is encoded by: hsa:10423
type: Species
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_8523e53e_2ca3_40ee_8f8d_741c20b2acb8
is: Q09327
name: MGAT3
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4248
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false

metaR UDPGLCAter
reactant: MODEL1310110054#
reversible: true
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000185
fast: false
is described by: ECO:0000269
type: Reaction

metaR FAOXC165C164m
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

metaR DNDPt14m
is: SBO:0000185
fast: false
reactant: MODEL1310110054#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110054#
reversible: false
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dUDP transport via dTDP antiport
product: MODEL1310110054#

metaM ksi pre23 g
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 23
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
constant: false

metaR RE1709C
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
product: MODEL1310110054#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110054#
name: RE1709
reactant: MODEL1310110054#
reversible: true

metaR GALASE5ly
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110054#
type: Reaction
name: beta-galactosidase, lysosomal
reactant: MODEL1310110054#
product: MODEL1310110054#
fast: false
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110054#_0fa13aec_3077_4d2c_b7b9_744b12bcf168
name: PDE4B
initial concentration: NaN
constant: false
is encoded by: hsa:5142
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is: Q5TEK5
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_34e7b6ad_17f5_43bf_bb61_07912aa6d9a9
initial concentration: NaN
is: P07205
has only substance units: false
type: Species
name: PGK2
boundary condition: true
is encoded by: hsa:5232
is: SBO:0000252
constant: false
initial amount: NaN

metaR RE3017R
product: MODEL1310110054#
name: RE3017
kinetic law: MODEL1310110054#
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9799565,PMID:9862787 NOTES:
reactant: MODEL1310110054#
type: Reaction
reversible: true

metaM udpg r
is: CHEBI:58367
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
has only substance units: false
constant: false
is: HMDB00286
boundary condition: false

metaR r1570
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110054#
type: Reaction
reversible: true
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_fafc681d_a920_4caf_8154_dbcf708ddaf1
is: SBO:0000297
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:5295
has part: P27986
boundary condition: true
constant: false
name: PIK3CA:PIK3R1

metaM uacgam c
constant: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: HMDB00290
is: SBO:0000247
boundary condition: false
is: CHEBI:57705

metaR S6T14g
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110054#
is described by: ECO:0000000
modifier: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_da4a8a4f_4e67_44da_9145_c1ec1958aad3
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P06132
is encoded by: hsa:7389
constant: false
name: UROD
is: SBO:0000252
initial amount: NaN
type: Species

metaR r2129
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110054#
is: SBO:0000185
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

metaM dgmp c
is: SBO:0000247
is: C00362
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
has only substance units: false
constant: false
is: CHEBI:57673
boundary condition: false
is: HMDB01044
name: dGMP
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_c5d94986_870f_4ccb_bcab_0742588b4bd0
name: SLCO1A2
has only substance units: false
boundary condition: true
initial amount: NaN
is: P46721
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:6579

metaR SERALANaEx
is: SBO:0000185
product: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110054#
name: L-alanine/L-serine Na-dependent exchange (Ser-L in)
is described by: ECO:0000269
modifier: MODEL1310110054#

metaM biliverd c
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
is: CHEBI:57991
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
is: HMDB01008
has only substance units: false
name: biliverdin(2-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_26c9ec96_d20c_43f7_b411_d038110916a8
name: PPCS
type: Species
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:79717
is: Q9HAB8
initial concentration: NaN
initial amount: NaN

metaR PYDXtr
is described by: ECO:0000000
name: Pyridoxal transport
fast: false
kinetic law: MODEL1310110054#
reversible: true
is: SBO:0000185
product: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT

metaR FAOXC16DCr
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

metaR DOLASNT Ler
product: MODEL1310110054#
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.1.119
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: NOTES:NCD
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (liver)
type: Reaction
reactant: MODEL1310110054#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_f60c8264_6313_4753_a8a0_08c4adafbe04
initial concentration: NaN
name: NDUFB6
boundary condition: true
is: O95139
type: Species
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:4712
is: SBO:0000252

metaR INSTt2r
is: SBO:0000185
kinetic law: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
modifier: MODEL1310110054#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
product: MODEL1310110054#
name: inositol transport in via proton symport
is described by: ECO:0000269

metaR TYMSFt
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
product: MODEL1310110054#
type: Reaction
fast: false
reactant: MODEL1310110054#
name: Tyramine O-sulfate transport (diffusion)
is described by: ECO:0000000
kinetic law: MODEL1310110054#
is: SBO:0000185

metaR r0836
type: Reaction
modifier: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000185
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.16
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
is described by: ECO:0000000

metaR 3DSPHR
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.1.1.102
modifier: MODEL1310110054#
name: 3-Dehydrosphinganine reductase
fast: false
type: Reaction
kinetic law: MODEL1310110054#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110054#_e668c712_5d69_44d1_928e_52c5cb413f47
name: ACY3
is: SBO:0000252
is encoded by: hsa:91703
initial amount: NaN
constant: false
has only substance units: false
is: Q96HD9
boundary condition: true
type: Species
initial concentration: NaN

metaM gdp n
name: GDP(3-)
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB01201
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: CHEBI:58189
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false

metaR r0839
is version of: http://identifiers.org/ec-code/1.3.1.70
modifier: MODEL1310110054#
fast: false
name: Postulated transport reaction
product: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000185
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
kinetic law: MODEL1310110054#
reversible: true
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_dd22567d_186f_48c2_a6aa_743d45024d50
type: Species
is encoded by: hsa:10166
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q9Y619
constant: false
is: SBO:0000252
initial amount: NaN
name: SLC25A15

metaM dolp U r
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
name: dolichyl phosphate(2-)
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: CHEBI:57683
type: Species
initial concentration: 1.0

metaR ECOAH12m
product: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is: SBO:0000176
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110054#
is described by: ECO:0000304
modifier: MODEL1310110054#
fast: false
reversible: true
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR AHEXASEly
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_9a6cec7a_0e2d_4cee_a3f8_a06904f71218
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
name: _AA177072_1_x
is encoded by: hsa:AA177072
boundary condition: true

metaM gmp c
is: CHEBI:58115
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: GMP
is: C00144
is: SBO:0000247
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
type: Species
constant: false
is: HMDB01397
boundary condition: false

metaR RE3568C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
product: MODEL1310110054#
is: SBO:0000176
fast: false
reactant: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110054#
name: RE3568
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_ff3e4acf_2c13_4893_bf7d_298e46633f45
is: Q6FIH7
constant: false
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:516
name: ATP5G1
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_2c85109a_e1a9_49bd_b30f_108751f26da9
constant: false
is: Q8NCL4
is: SBO:0000252
type: Species
name: GALNT6
initial concentration: NaN
is encoded by: hsa:11226
boundary condition: true
has only substance units: false
initial amount: NaN

metaM gdp m
type: Species
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201
is: SBO:0000247
constant: false
has only substance units: false
name: GDP
is: C00035
initial amount: NaN
is: CHEBI:58189
initial concentration: 1.0
boundary condition: false

metaR GDPtg
type: Reaction
reactant: MODEL1310110054#
name: GDP intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110054#
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_33de4e32_55ab_40dd_9f40_a14e2c569d35
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
name: PIK3C2G
is: O75747
has only substance units: false
is encoded by: hsa:5288
initial amount: NaN
boundary condition: true

metaR ACCOAtn
fast: false
is described by: ECO:0000000
name: acetyl-CoA transport, nuclear
type: Reaction
reversible: true
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#

metaR r0838
is version of: http://identifiers.org/ec-code/3.1.2.4
product: MODEL1310110054#
fast: false
modifier: MODEL1310110054#
name: Free diffusion
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110054#_148be341_6b58_4222_b3cf_c4c54abb4538
is: Q9H008
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:64077
has only substance units: false
name: LHPP
type: Species
initial amount: NaN

metaM chsterol l
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB00067
constant: false
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
has only substance units: false
name: cholesterol
is: CHEBI:16113

http://identifiers.org/biomodels.db/MODEL1310110054#_c7123b23_6c91_465c_a619_2ee0da129633
initial concentration: NaN
name: NSDHL
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:50814
is: Q15738
has only substance units: false
boundary condition: true
constant: false

metaM uacgam g
is: HMDB00290
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
initial amount: NaN
is: SBO:0000247
constant: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:57705

metaM ksi deg8 l
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00143
is: SBO:0000247
is: CHEBI:12936
type: Species
boundary condition: false
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
name: keratan sulfate I, degradation product 8
has only substance units: false

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_7d23dad4_e1a5_4a9e_98fa_299955b18c91
constant: false
boundary condition: true
name: _AL038231_1_c
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:AL038231
type: Species
is: SBO:0000252

metaR H2Otly
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110054#
name: H2O transport, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000
product: MODEL1310110054#
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_59ce8f5f_2627_4eb0_8245_b7e3bc23306d
initial concentration: NaN
is encoded by: hsa:4698
initial amount: NaN
is: Q16718
is: SBO:0000252
name: NDUFA5
boundary condition: true
has only substance units: false
constant: false
type: Species

metaR RE3520E
reversible: true
kinetic law: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
is version of: http://identifiers.org/ec-code/1.11.1.9
is described by: ECO:0000000
name: RE3520
modifier: MODEL1310110054#
is: SBO:0000176
fast: false
reactant: MODEL1310110054#

metaM prostgi2 e
is: CHEBI:57403
is: HMDB01335
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: prostaglandin I2(1-)
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
initial concentration: 1.0

metaR RE0830C
name: RE0830
type: Reaction
product: MODEL1310110054#
reversible: true
fast: false
kinetic law: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110054#

metaR GLNSERNaEx
name: L-serine/L-glutamine Na-dependent exchange (Gln-L in)
is described by: ECO:0000269
kinetic law: MODEL1310110054#
fast: false
reversible: false
product: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_2c14fe9a_d927_4f55_b953_48142e4a91e3
initial amount: NaN
constant: false
is: Q02221
is encoded by: hsa:1339
is: SBO:0000252
type: Species
boundary condition: true
name: COX6A2
initial concentration: NaN
has only substance units: false

metaM ksi deg6 l
name: keratan sulfate I, degradation product 6
is: CHEBI:12936
initial concentration: 1.0
is: HMDB00143
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
type: Species

metaR r1546
is: SBO:0000185
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_ce0851a4_8b37_4524_b687_39cabb14b8bd
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
name: _D87002_1_m
constant: false
initial amount: NaN
is encoded by: hsa:D87002
boundary condition: true

metaR N4Tg
is: SBO:0000176
name: N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus
kinetic law: MODEL1310110054#
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
reactant: MODEL1310110054#
type: Reaction

metaR r2379
product: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110054#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaR ATPtx
type: Reaction
product: MODEL1310110054#
is described by: ECO:0000000
reactant: MODEL1310110054#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
name: ATP transporter, peroxisomal

metaR UAG4E
name: UDP-N-acetylglucosamine 4-epimerase
is described by: ECO:0000304
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/5.1.3.2
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#
type: Reaction
product: MODEL1310110054#

metaR r0181
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
modifier: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110054#
type: Reaction
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000
reversible: true

metaR G3PD1
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
is described by: ECO:0000269
type: Reaction
reversible: true
kinetic law: MODEL1310110054#
name: glycerol-3-phosphate dehydrogenase (NAD)
is version of: http://identifiers.org/ec-code/1.1.1.8
is: SBO:0000176
modifier: MODEL1310110054#
fast: false
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_b111c5f4_a987_44e4_bd25_0fc7c6caae26
initial amount: NaN
is encoded by: hsa:1351
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is: Q53XN1
constant: false
name: COX8A

metaR G6PDH2rer
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.1.1.47
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
is described by: ECO:0000269

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaR PPD2CSPp
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
product: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
is: SBO:0000176
name: PPD2CSPp
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reversible: false

metaR r1547
type: Reaction
is: SBO:0000185
reactant: MODEL1310110054#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110054#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110054#

metaR CYSGLUexR
is: SBO:0000185
reversible: true
modifier: MODEL1310110054#
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110054#
reactant: MODEL1310110054#
name: L-cysteine/L-glutamine reversible exchanger
kinetic law: MODEL1310110054#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_a104bad9_72c5_4817_9466_f3d74e8cf8b6
type: Species
initial amount: NaN
name: GPX3
is: P22352
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2878

metaM core2 g
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15876
name: Core 2
boundary condition: false
notes: FORMULA: C22H37N2O15X CHARGE: 0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_3e107440_38ee_420e_8fc9_5a83e6938ee3
is encoded by: hsa:226
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P04075
is: SBO:0000252
constant: false
boundary condition: true
type: Species
name: ALDOA

metaM 7thf e
notes: FORMULA: C49H57N13O24 CHARGE: -8
name: heptaglutamyl folate (THF)
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB06559
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN

metaM pser L c
is: SBO:0000247
name: O-Phospho-L-serine
type: Species
boundary condition: false
constant: false
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
is: HMDB01721
initial amount: NaN
has only substance units: false
is: CHEBI:15811
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_34549761_3f62_4cf8_9f48_f8a28b8eca9a
is encoded by: hsa:2182
name: ACSL4
type: Species
is: SBO:0000252
is: Q5JWV8
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true

metaM CE4792 m
is: CHEBI:57923
name: 3-oxo-cis-8-tetradecenoyl-CoA
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_6dbcff2f_df3a_4c8b_acdb_57548a7ee9ed
initial concentration: NaN
boundary condition: true
name: DDOST
has only substance units: false
is encoded by: hsa:1650
constant: false
is: P39656
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_188995db_17c1_40a8_b6c6_a780c09ab8c0
constant: false
is encoded by: hsa:219
initial concentration: NaN
initial amount: NaN
is: P30837
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
name: ALDH1B1

http://identifiers.org/biomodels.db/MODEL1310110054#_5a8b0412_5622_4b7a_bc43_6d77a71ae37b
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: UMPS
has only substance units: false
is: A8K5J1
is encoded by: hsa:7372
initial concentration: NaN

metaR r1548
type: Reaction
kinetic law: MODEL1310110054#
fast: false
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#

metaR CYOR u10m
type: Reaction
is described by: ECO:0000134
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.92
name: ubiquinol-6 cytochrome c reductase, Complex III
is: SBO:0000185
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
reactant: MODEL1310110054#
product: MODEL1310110054#

metaR THRCYSNaEx
kinetic law: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
is described by: ECO:0000269
name: L-cysteine/L-threonine Na-dependent exchange (Thr-L in)
reactant: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110054#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110054#_62df9b64_f80c_43ba_a6bc_d88e7fd51d38
initial concentration: NaN
has part: P42336
is encoded by: hsa:5296
has part: O00459
initial amount: NaN
type: Species
boundary condition: true
name: PIK3CA:PIK3R2
constant: false
is: SBO:0000297
is encoded by: hsa:5290
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_341d4c2f_8b8c_4fa4_bab7_72b6aacc33c7
is: SBO:0000252
type: Species
is: Q96T66
initial amount: NaN
has only substance units: false
boundary condition: true
name: NMNAT3
constant: false
initial concentration: NaN
is encoded by: hsa:349565

metaR EX hestratriol LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4,17 dihydroxy estradiol exchange
type: Reaction

metaR r0747
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
modifier: MODEL1310110054#
product: MODEL1310110054#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110054#_76d0100a_3858_428d_96a2_1b6ff6ac45db
initial concentration: NaN
is: SBO:0000252
name: NDUFC2
has only substance units: false
constant: false
is: Q549M5
type: Species
initial amount: NaN
is encoded by: hsa:4718
boundary condition: true

metaM ksi pre11 g
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
has only substance units: false
constant: false
type: Species
is: SBO:0000247
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 11

http://identifiers.org/biomodels.db/MODEL1310110054#_6acc3083_9ce3_4623_8d8a_0ef6595394d9
constant: false
has part: E5KS60
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000297
is encoded by: hsa:8803
name: SUCLG1:SUCLA2
initial concentration: NaN

metaR r0594
reversible: true
product: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
modifier: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
reactant: MODEL1310110054#

metaM nadp c
is: CHEBI:58349
is: SBO:0000247
type: Species
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: C00006
is: HMDB00217

http://identifiers.org/biomodels.db/MODEL1310110054#_8701700e_3c25_4ef1_a47e_90470a41587e
is: SBO:0000252
constant: false
type: Species
name: ATP1B3
initial concentration: NaN
is: P54709
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:483

http://identifiers.org/biomodels.db/MODEL1310110054#_74c7a88c_c3d3_4eaf_96b1_5d2dfa17b085
type: Species
is: P04843
is encoded by: hsa:6184
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
name: RPN1
initial concentration: NaN
boundary condition: true

metaR SUCCTD
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaM ahcys m
name: S-Adenosyl-L-homocysteine
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: CHEBI:16680
is: C00021
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00939

metaR r1549
is: SBO:0000185
reactant: MODEL1310110054#
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110054#
fast: false
product: MODEL1310110054#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM succ m
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:30031
name: Succinate
initial amount: NaN
has only substance units: false
is: C00042
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: HMDB00254

metaR r2376
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110054#
reversible: true
fast: false
kinetic law: MODEL1310110054#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110054#
is described by: ECO:0000000
type: Reaction

metaR PETOHMr hs
is described by: ECO:0000254
reactant: MODEL1310110054#
is: SBO:0000176
type: Reaction
product: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-Prot] NJ
is version of: http://identifiers.org/ec-code/2.1.1.17
reversible: false
kinetic law: MODEL1310110054#
fast: false
name: phosphatidylethanolamine N-methyltransferase

metaM s2l2n2m2m l
constant: false
notes: FORMULA: C84H136N6O62 CHARGE: -2
type: Species
is: SBO:0000247
is: HMDB02177
initial concentration: 1.0
boundary condition: false
name: de-Fuc form of PA6 (w/o peptide linkage)
is: CHEBI:36033
initial amount: NaN
has only substance units: false

metaM adrn c
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
has only substance units: false
initial concentration: 1.0
is: HMDB02226
is: CHEBI:53487
initial amount: NaN
name: adrenic acid
type: Species
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_2a09d4fb_a5b6_4fe5_97df_728886beeec2
boundary condition: true
type: Species
name: B3GALNT1
is: Q8TDY1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8706
constant: false
has only substance units: false

metaR OAGD3te
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
product: MODEL1310110054#
reactant: MODEL1310110054#
name: oagd3 hs transport
is: SBO:0000185

metaR r0480
fast: false
product: MODEL1310110054#
type: Reaction
reversible: true
kinetic law: MODEL1310110054#
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is described by: ECO:0000000
reactant: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR EX gly LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Glycine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_acf6ffff_2db9_4cb0_b694_70f20c6f1830
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q6ZWP6
is: SBO:0000252
is encoded by: hsa:27034
constant: false
name: ACAD8
initial amount: NaN

metaR r2375
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110054#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110054#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110054#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_fefa704a_aeae_45a7_bd34_60b49a6b6487
is: Q4KWH8
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
name: PLCH1
is encoded by: hsa:23007
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_4a13f92b_c10d_4709_ab3e_ac4dbf0772ec
boundary condition: true
type: Species
is: Q8TE04
name: PANK1
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:53354
initial concentration: NaN

metaR r2378
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110054#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_260d8529_4f76_47d7_9243_67141a5ec63e
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
name: ST3GAL3
type: Species
is encoded by: hsa:6487
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_d0a8e96a_efbd_4988_817f_4093714c6bbf
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10380
boundary condition: true
constant: false
is: O95861
initial concentration: NaN
name: BPNT1

metaR r0483
product: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
reactant: MODEL1310110054#
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
kinetic law: MODEL1310110054#
type: Reaction

metaM prostgi2 c
is: SBO:0000247
is: CHEBI:57403
has only substance units: false
constant: false
boundary condition: false
type: Species
name: prostaglandin I2(1-)
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: HMDB01335

metaM cholcoar r
is: HMDB02178
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
initial amount: NaN
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58677
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
boundary condition: false

metaM mag hs e
name: monoacylglycerol 2
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
constant: false
has only substance units: false
type: Species
is: HMDB03073
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:32391

http://identifiers.org/biomodels.db/MODEL1310110054#_f9d700d4_23be_4780_a0e9_233355fb86ba
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:762
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: CA4
is: Q6FHI7

metaM 20ahchsterol m
is: HMDB06283
is: SBO:0000247
is: CHEBI:1296
constant: false
name: 20-hydroxycholesterol
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM adrn e
has only substance units: false
is: SBO:0000247
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
constant: false
is: HMDB02226
type: Species
is: CHEBI:53487
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: adrenic acid

metaR r0596
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
is: SBO:0000176
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
reversible: false
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
reactant: MODEL1310110054#
fast: false
product: MODEL1310110054#

metaR r0744
product: MODEL1310110054#
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
is: SBO:0000176
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#

metaR FACOAL2042
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
name: fatty-acid--CoA ligase
product: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
modifier: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_45cd3f6a_5cad_474f_8eab_dd019325aafe
has only substance units: false
is: P78356
is encoded by: hsa:8396
constant: false
is: SBO:0000252
name: PIP4K2B
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_0a3a450c_191f_4f1a_ac8f_602ad7eb7b2d
constant: false
name: NPR2
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:4882
has only substance units: false
is: P20594
initial concentration: NaN
is: SBO:0000252

metaR r0595
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 2.8.1.2 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:851908 NOTES:
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: false
product: MODEL1310110054#
name: 3-Mercaptopyruvate:cyanide sulfurtransferase Cysteine metabolism EC:2.8.1.2
fast: false
type: Reaction
is described by: ECO:0000000

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaM asp L m
boundary condition: false
name: L-aspartate(1-)
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: CHEBI:29991
initial concentration: 1.0
is: HMDB00191
is: SBO:0000247

metaM hs deg20 l
has only substance units: false
type: Species
is: HMDB00127
constant: false
name: heparan sulfate, degradation product 20
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:15748

http://identifiers.org/biomodels.db/MODEL1310110054#_2feddfa3_32cc_499d_ac1f_fdbd599491b1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:114134
name: SLC2A13
constant: false
type: Species
is: Q96QE2
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_eb89e36b_86d9_4182_ac37_c189dbf5f974
is encoded by: hsa:4706
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: NDUFAB1
is: O14561

http://identifiers.org/biomodels.db/MODEL1310110054#_a8fa3479_2f52_4e47_9858_e55b09f1b64b
type: Species
is: Q02338
initial concentration: NaN
initial amount: NaN
name: BDH1
constant: false
is encoded by: hsa:622
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR r0743
type: Reaction
reversible: false
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
is described by: ECO:0000000
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_96480ad5_0378_480e_98e5_185e349e7df3
is: SBO:0000252
name: SLC20A2
initial amount: NaN
boundary condition: true
is: B2RBR4
has only substance units: false
type: Species
is encoded by: hsa:6575
initial concentration: NaN
constant: false

metaR RE3556C
reversible: true
fast: false
is: SBO:0000176
name: RE3556
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110054#

metaR r2377
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
product: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_2daed1e0_5c9e_4b28_b5ea_7e684722fa56
type: Species
name: OXSM
boundary condition: true
constant: false
is: Q9NWU1
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:54995

http://identifiers.org/biomodels.db/MODEL1310110054#_90732bc5_4582_4022_a02b_7f57acc4bfd0
has part: Q6I9V2
is: SBO:0000297
initial amount: NaN
constant: false
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
has only substance units: false
initial concentration: NaN
has part: P25705
boundary condition: true
is encoded by: hsa:498
is encoded by: hsa:509
type: Species

metaM pail4p hs n
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
type: Species
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
is: CHEBI:58178
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false

metaM pe hs r
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16038
type: Species
initial amount: NaN
name: phosphatidylethanolamine
has only substance units: false
constant: false
initial concentration: 1.0

metaR Coqe
kinetic law: MODEL1310110054#
name: Transport of q10
is described by: ECO:0000134
type: Reaction
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110054#

metaM 11 cis retfa e
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
has only substance units: false
constant: false
is: HMDB00972
is: SBO:0000247
boundary condition: false
name: fatty acid 11-cis-retinol
is: CHEBI:57454

metaM ahcys r
notes: FORMULA: C14H20N6O5S CHARGE: 0 INCHI: InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
constant: false
name: S-adenosyl-L-homocysteine
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:16680
is: HMDB00939

metaM vitd3 c
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
boundary condition: false
is: HMDB00876
is: SBO:0000247
initial concentration: 1.0
name: calciol
constant: false
is: CHEBI:28940

http://identifiers.org/biomodels.db/MODEL1310110054#_e0a3ecc9_baf1_4dc8_b927_ee7afab3fe4a
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
name: _AI620219_1_m
type: Species
is encoded by: hsa:AI620219
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_ab8ef037_ef9c_4585_8ef4_3e0b1c5ab059
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: _X63359_1_c
initial concentration: NaN
is encoded by: hsa:X63359

metaM orn c
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H13N2O2 CHARGE: 1
boundary condition: false
is: C01602
is: SBO:0000247
is: CHEBI:0
has only substance units: false
name: Ornithine
is: HMDB00214

http://identifiers.org/biomodels.db/MODEL1310110054#_662cc8af_55c0_4100_a63d_7f573bdf5f3e
type: Species
boundary condition: true
is: SBO:0000252
name: DGUOK
constant: false
is encoded by: hsa:1716
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: E5KSL6

metaM mag hs c
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
is: HMDB12130
type: Species
name: monoacylglycerol 2
is: CHEBI:16987
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR PROSTGH2t
type: Reaction
is: SBO:0000185
reactant: MODEL1310110054#
name: Prostaglandin H2 transport
fast: false
is described by: ECO:0000269
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
reversible: true
kinetic law: MODEL1310110054#

metaR EX 34hpp
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_85d5b94c_c262_45d5_8676_5dc06b774b01
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
name: LTA4H
type: Species
initial concentration: NaN
is encoded by: hsa:4048
boundary condition: true
is: P09960

metaR r0590
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110054#
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
reactant: MODEL1310110054#
type: Reaction
fast: false

metaR RE3015R
reactant: MODEL1310110054#
name: RE3015
is described by: ECO:0000000
type: Reaction
reversible: false
modifier: MODEL1310110054#
product: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8529.1) or (4051.1) or (126410.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.13.30 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9799565,PMID:9862787 NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.30

metaR r0741
type: Reaction
reversible: true
product: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110054#
is: SBO:0000176
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
is described by: ECO:0000000
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m

metaR MMTSADm
kinetic law: MODEL1310110054#
type: Reaction
fast: false
reversible: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1527093 NOTES:MM. biochemical activity measured in rat, sequence similarity found in human
is: SBO:0000176
is described by: ECO:0000000
name: malonate-semialdehyde dehydrogenase (acetylating), mitochondrial
reactant: MODEL1310110054#

metaM gdpddman c
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB01346
is: SBO:0000247
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222
constant: false
initial amount: NaN
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
is: CHEBI:57964
boundary condition: false

metaM gum e
has only substance units: false
constant: false
notes: FORMULA: C2760000H5060000O2530000 CHARGE: 0
name: gums
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/97415
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_acc44acd_2c5b_495e_97ef_a122394d7e9d
is encoded by: hsa:33
name: ACADL
is: P28330
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_34664ba5_9603_4a7c_baa3_eaa19fc0b40e
is: SBO:0000252
name: ALG8
type: Species
is encoded by: hsa:79053
is: Q9BVK2
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN

metaR PPCDC
kinetic law: MODEL1310110054#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/4.1.1.36
reversible: false
name: phosphopantothenoylcysteine decarboxylase
type: Reaction
fast: false
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_12e5dd31_9028_4ab4_b62e_346c7230b16e
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:3418
name: IDH2
initial amount: NaN
is: P48735
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR P5CDm
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
modifier: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110054#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.5.1.12

metaR FAOXC102C81x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_096f5b2a_683a_48e5_9f78_cdcf22fe8b6f
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
name: _AI469183_1_x
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:AI469183

http://identifiers.org/biomodels.db/MODEL1310110054#_9cdfb77a_cf11_4fc0_8a9b_7c422dfda576
has only substance units: false
name: HSD17B10
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3028
is: Q99714
initial amount: NaN
constant: false
type: Species
is: SBO:0000252

metaR r0853
product: MODEL1310110054#
name: Facilitated diffusion
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
reversible: false
type: Reaction
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#

metaM mercplac c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB02127
initial amount: NaN
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
type: Species
name: 3-Mercaptolactate
is: C05823
is: http://identifiers.org/pubchem.compound/8118
has only substance units: false

metaR DITPtn
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110054#
product: MODEL1310110054#
name: dITP nuclear transport
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_1f467d18_0990_4d88_a2ad_87a36ccef6cb
is: E5KSL6
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: DGUOK
boundary condition: true
is encoded by: hsa:1716
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_2670ca52_619b_4689_ac76_d5aa1b62c45d
name: IVD
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:3712
constant: false
initial concentration: NaN
has only substance units: false
is: B3KVI7
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_05e9f7f9_560b_46d8_8c77_67fd519f8132
is encoded by: hsa:AA502753
constant: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: _AA502753_1_m

http://identifiers.org/biomodels.db/MODEL1310110054#_e059e878_6034_4f2d_bf99_81d0eaa1aeab
initial amount: NaN
type: Species
initial concentration: NaN
name: GALNT1
boundary condition: true
has only substance units: false
is: Q10472
is: SBO:0000252
is encoded by: hsa:2589
constant: false

metaR AG13T17g
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110054#
product: MODEL1310110054#
modifier: MODEL1310110054#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110054#
type: Reaction
is: SBO:0000176
reversible: false

metaM cholcoa x
name: choloyl-CoA(4-)
is: CHEBI:57373
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
is: HMDB01374
is: SBO:0000247

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaM cdpea c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: cdpea[c]
notes: FORMULA: C11H19N4O11P2 CHARGE: -1 INCHI: InChI=1S/C11H20N4O11P2/c12-2-4-23-27(19,20)26-28(21,22)24-5-6-8(16)9(17)10(25-6)15-3-1-7(13)14-11(15)18/h1,3,6,8-10,16-17H,2,4-5,12H2,(H,19,20)(H,21,22)(H2,13,14,18)/p-1/t6-,8-,9-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00433 EHMN_ABBREVIATION: C00570
is: HMDB01564
boundary condition: false
type: Species
constant: false
is: CHEBI:57876
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_97dcd1d2_d810_46a1_9db8_85383b973352
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
is: P00491
name: PNP
is encoded by: hsa:4860

metaR DOPAt4 2 r
fast: false
is described by: ECO:0000269
reversible: true
is: SBO:0000185
name: Dopamine reversible transport in via sodium symport (1:2)
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction

metaR C4tcx
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine from peroxisomes
type: Reaction

metaM cs a l
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
is: HMDB02183
is: CHEBI:36005
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_d8baafdc_dc9d_4330_8114_7d887af1924d
is: Q6FG42
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4701
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
name: NDUFA7
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_c4ae6e7b_8a8c_4e98_9e3e_08cf514b37e8
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:80201
type: Species
name: HKDC1
has only substance units: false
boundary condition: true
is: B3KT70
constant: false

metaR G13MT L
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110054#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.132
fast: false
modifier: MODEL1310110054#
reversible: false
kinetic law: MODEL1310110054#
name: Glycolipid 1,3-alpha-D-mannosyltransferase (liver)
type: Reaction
product: MODEL1310110054#
is described by: ECO:0000000

metaM orn e
is: SBO:0000247
is: C01602
is: HMDB00214
initial amount: NaN
boundary condition: false
has only substance units: false
name: Ornithine
is: CHEBI:0
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C5H13N2O2 CHARGE: 1

metaR ARABR
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
type: Reaction
name: arabinose reductase
reactant: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#
reversible: false
modifier: MODEL1310110054#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21

metaR FAOXC204C205x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C20:5)x
type: Reaction

metaR THCHOLSTOICtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_58ebcaf2_90f2_49a5_a2f3_88d85fb120a8
name: ST3GAL3
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:6487

http://identifiers.org/biomodels.db/MODEL1310110054#_4967aaa6_46c3_44ca_8e1c_5d290d8174e5
boundary condition: true
type: Species
has only substance units: false
is: Q9BT22
initial concentration: NaN
constant: false
name: ALG1
is: SBO:0000252
is encoded by: hsa:56052
initial amount: NaN

metaR PMTCOAtx
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
is: SBO:0000185
is described by: ECO:0000000
name: fatty acid intracellular transport
reactant: MODEL1310110054#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_b88c5cd3_797d_41ed_a3a0_71474635ee2b
name: SDHA
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: P31040
has only substance units: false
type: Species
is encoded by: hsa:6389
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_5e2d2165_aa48_447d_b252_281dd27d8244
initial amount: NaN
name: NDUFC2
boundary condition: true
type: Species
has only substance units: false
is: Q549M5
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4718

http://identifiers.org/biomodels.db/MODEL1310110054#_a4ec7042_e7ce_431e_b2eb_8136d58bf651
is: SBO:0000252
is encoded by: hsa:6799
name: SULT1A2
boundary condition: true
constant: false
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_42af266e_173b_4040_bf75_438f17f20dc3
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:5141
name: PDE4A
is: P27815

metaM CE2247 c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29(49)24-32(51)70-23-22-43-31(50)20-21-44-39(54)36(53)41(2,3)26-63-69(60,61)66-68(58,59)62-25-30-35(65-67(55,56)57)34(52)40(64-30)48-28-47-33-37(42)45-27-46-38(33)48/h27-30,34-36,40,49,52-53H,4-26H2,1-3H3,(H,43,50)(H,44,54)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/t29?,30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: CE2247
is: SBO:0000247
name: 3-hydroxyeicosanoyl-CoA
is: CHEBI:52324
has only substance units: false

metaR r0591
is described by: ECO:0000000
reactant: MODEL1310110054#
reversible: true
is: SBO:0000176
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#

metaR OAGD3tg
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
name: oagd3 hs intracellular transport
fast: false

metaR r1106
kinetic law: MODEL1310110054#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110054#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110054#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_036f072b_d01c_4e0c_8ef6_2de1602bbaef
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:60490
boundary condition: true
initial amount: NaN
name: PPCDC
is: SBO:0000252
has only substance units: false
is: Q96CD2

metaR MMSAD1m
reversible: false
name: methylmalonate-semialdehyde dehydrogenase
product: MODEL1310110054#
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.2.1.27
is described by: ECO:0000269
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_020172ab_6c68_46d1_bb6c_a324e97fc009
boundary condition: true
is encoded by: hsa:26289
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
name: AK5

metaM succ e
boundary condition: false
initial concentration: 1.0
is: HMDB00254
type: Species
initial amount: NaN
constant: false
name: succinate(2-)
is: CHEBI:30031
has only substance units: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_1e43fda7_0db6_4748_8e85_b4a4081f4eec
initial concentration: NaN
name: IDH2
is: P48735
boundary condition: true
is encoded by: hsa:3418
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_2c4b9f95_92c8_484b_be93_086c0678c584
is: SBO:0000252
is: O43286
name: B4GALT5
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:9334

metaR GUACYC
is version of: http://identifiers.org/ec-code/4.6.1.2
kinetic law: MODEL1310110054#
name: guanylate cyclase
notes: GENE_ASSOCIATION: (2977.1 and 2983.1) or (4882.2) or (2982.1 and 2974.1) or (2986.1) or (4882.1) or (2984.1) or (4881.1) or (2977.1 and 2974.1) or (3000.1) or (2982.1 and 2983.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.2 Confidence Level: 4 AUTHORS: PMID:10449911,PMID:10777682,PMID:11565546,PMID:11851379,PMID:1352257,PMID:14748740,PMID:15371450,PMID:7601467,PMID:7761400,PMID:7777544,PMID:7954658,PMID:8838319,PMID:9097965,PMID:9742212 NOTES:IT
product: MODEL1310110054#
reversible: false
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
fast: false

metaR r1260
fast: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: EC:6.2.1.3
type: Reaction
kinetic law: MODEL1310110054#
reversible: false
is: SBO:0000176
reactant: MODEL1310110054#
is described by: ECO:0000000

metaR S6TASE12ly
is: SBO:0000176
modifier: MODEL1310110054#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#
type: Reaction
reversible: true

metaM leuleu c
type: Species
is: SBO:0000247
boundary condition: false
constant: false
name: Leucylleucine
initial concentration: 1.0
notes: FORMULA: C12H24N2O3 CHARGE: 0
has only substance units: false
is: http://identifiers.org/pubchem.compound/94244
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_6e7ec493_2204_49e5_9f75_81b6295ac8de
initial concentration: NaN
is encoded by: hsa:6487
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
name: ST3GAL3

http://identifiers.org/biomodels.db/MODEL1310110054#_d2e29e00_3dfa_42d7_a88d_6e0fe889dd09
initial concentration: NaN
name: PIK3CD
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:5293
boundary condition: true
is: A7E2E0
has only substance units: false

metaR r1695
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000185
kinetic law: MODEL1310110054#
is described by: ECO:0000000
product: MODEL1310110054#
name: Y+LAT2 Utilized transport
type: Reaction
fast: false

metaM pe hs m
constant: false
initial amount: NaN
has only substance units: false
name: phosphatidylethanolamine
is: SBO:0000247
is: CHEBI:16038
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350

http://identifiers.org/biomodels.db/MODEL1310110054#_1889bc59_8119_45f8_a7eb_f054c7b86f66
is: SBO:0000252
type: Species
is encoded by: hsa:83549
has only substance units: false
is: Q5JT09
initial amount: NaN
name: UCK1
boundary condition: true
initial concentration: NaN
constant: false

metaR r0488
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
reactant: MODEL1310110054#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
product: MODEL1310110054#
type: Reaction
fast: false
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34

metaM ksi deg27 l
is: HMDB00143
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:12936
boundary condition: false
initial amount: NaN
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
name: keratan sulfate I, degradation product 27
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_2eb5b406_1482_47c4_88f1_9ad7e9109596
has only substance units: false
is: Q7Z725
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
name: SLC34A1
initial amount: NaN
constant: false
is encoded by: hsa:6569

http://identifiers.org/biomodels.db/MODEL1310110054#_ed248a1c_999a_48e7_804a_faeef270d061
is: P28330
constant: false
name: ACADL
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:33
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_dd2f5b06_273f_45d6_b078_1aeb670b293e
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
name: _D87002_1_e
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:D87002
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_6892df8c_10c0_4018_b028_687763f410f0
has only substance units: false
type: Species
initial concentration: NaN
is: Q13057
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:80347
name: COASY

metaM succ c
initial concentration: 1.0
name: Succinate
is: SBO:0000247
is: C00042
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: HMDB00254
type: Species
is: CHEBI:30031
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false

metaR GALASE9ly
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110054#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
name: beta-galactosidase, lysosomal

metaM vitd3 e
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
is: HMDB00876
is: SBO:0000247
constant: false
boundary condition: false
type: Species
is: CHEBI:28940
name: calciol
has only substance units: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_0f2d2a44_5bef_4c55_b6f2_89e8827c9a89
is: SBO:0000252
constant: false
is encoded by: hsa:9061
initial concentration: NaN
is: O43252
has only substance units: false
initial amount: NaN
type: Species
name: PAPSS1
boundary condition: true

metaM leuleu e
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
name: Leucylleucine
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/94244
initial amount: NaN
constant: false
notes: FORMULA: C12H24N2O3 CHARGE: 0

metaM 35cgmp c
has only substance units: false
constant: false
is: CHEBI:57746
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
name: 3',5'-cyclic GMP(1-)
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
is: HMDB01314
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_f4a16b37_cf56_4925_8797_56294d0f876d
is: SBO:0000252
type: Species
initial amount: NaN
name: GALNT9
is: Q9HCQ5
has only substance units: false
is encoded by: hsa:50614
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_ffca72e2_3b90_4527_a8a6_f3f958fcbb32
initial concentration: NaN
is: Q9ULC5
boundary condition: true
name: ACSL5
constant: false
has only substance units: false
is encoded by: hsa:51703
initial amount: NaN
is: SBO:0000252
type: Species

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_fd23d55e_db35_41af_93a6_6cc87ef48a39
is: Q9Y5P4
constant: false
is encoded by: hsa:10087
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: COL4A3BP
is: SBO:0000252
boundary condition: true

metaR RETH2e
is described by: ECO:0000000
reactant: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
product: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
reversible: false
name: retinyl ester hydrolase (11-cis), extracellular

metaM asp L e
type: Species
has only substance units: false
constant: false
boundary condition: false
name: L-aspartate(1-)
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: CHEBI:29991
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00191

http://identifiers.org/biomodels.db/MODEL1310110054#_30fd83f6_71d0_4d90_805f_9b1e649dbdb6
is encoded by: hsa:79017
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: GGCT
type: Species
is: B8ZZR8
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_6e301861_f49c_431f_a0b3_b1e19e622f8b
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
name: ALDH7A1
constant: false
is encoded by: hsa:501
is: E7EPT3

http://identifiers.org/biomodels.db/MODEL1310110054#_f76cbb74_0eb6_40da_b275_ec3710c2e0cf
initial amount: NaN
initial concentration: NaN
name: B3GALNT1
is: O75752
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:8706

metaM HC00695 m
is: SBO:0000247
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
boundary condition: false
name: S-Succinyldihydrolipoamide
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:17432
constant: false
type: Species

metaR DNDPt26m
is described by: ECO:0000269
reactant: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
name: dCDP transport via dUDP antiport
product: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
fast: false
reversible: false

metaR HEXDIACTD
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_f6ddff1f_b6e0_4db8_8ad4_81ea756de4f1
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
name: ATP5G1
is encoded by: hsa:516
initial amount: NaN
is: P05496
initial concentration: NaN
constant: false

metaR CYOOm3
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
fast: false
name: cytochrome c oxidase, mitochondrial Complex IV
product: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: false
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.9.3.1
is described by: ECO:0000134
type: Reaction
is: SBO:0000185

metaR ECOAH9m
is described by: ECO:0000304
reversible: true
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
type: Reaction
is: SBO:0000176
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_82ccb224_c877_4049_8623_12a3d555455e
type: Species
is: SBO:0000252
constant: false
name: PEMT
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10400

metaM Lkynr c
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00684
is: SBO:0000247
is: CHEBI:16946
name: L-kynurenine
initial amount: NaN
type: Species

metaR C40CPT1
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_d0fb88c3_7489_465e_9389_60a7588bad65
boundary condition: true
is encoded by: hsa:10559
name: SLC35A1
has only substance units: false
is: P78382
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
constant: false

metaR r1827
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000185
kinetic law: MODEL1310110054#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110054#
name: Y+LAT2 Utilized transport

metaR GUAPRT
modifier: MODEL1310110054#
name: guanine phosphoribosyltransferase
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
product: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.2.8
reactant: MODEL1310110054#

metaM asp L c
constant: false
type: Species
name: L-aspartate(1-)
is: HMDB00191
has only substance units: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:29991
boundary condition: false

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaM mi14p c
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
initial amount: NaN
is: SBO:0000247
is: CHEBI:58282
boundary condition: false
is: HMDB00968
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
type: Species
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_d24be80e_aa87_4b72_9db5_78a4a87ea578
is: P43007
initial amount: NaN
constant: false
is: SBO:0000252
name: SLC1A4
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6509
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_e798979a_4fff_4f7a_a81a_35b9bd33d687
is: SBO:0000252
has only substance units: false
is encoded by: hsa:195814
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: B3KT84
constant: false
name: SDR16C5

metaM aicar e
constant: false
is: HMDB01517
type: Species
initial amount: NaN
notes: FORMULA: C9H13N4O8P CHARGE: -2
has only substance units: false
initial concentration: 1.0
is: C04677
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: SBO:0000247
is: CHEBI:58475
boundary condition: false

metaM ura e
initial amount: NaN
initial concentration: 1.0
is: HMDB00300
name: uracil
is: CHEBI:17568
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
type: Species
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_f4e089fe_2876_4f85_8740_a390419974a8
is encoded by: hsa:51166
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
name: AADAT
constant: false
is: Q4W5N8
type: Species
initial amount: NaN

metaR G12MT2 U
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110054#
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
reactant: MODEL1310110054#
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110054#_d4aad477_8ecd_452f_a4a6_f64419efaabc
boundary condition: true
name: AK2
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:204
type: Species
initial concentration: NaN

metaR CYSSNAT5tc
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_14b7d240_dd27_41da_8573_b918995ff6fd
is encoded by: hsa:1798
is: Q9H3H5
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
name: DPAGT1
boundary condition: true

metaR r2497
is described by: ECO:0000000
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
type: Reaction
reversible: false
is: SBO:0000185
fast: false
product: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:

metaR GTMLTe
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.3.2.2
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES:NCD SAB e see Disussion section of PMID 15469854
fast: false
reversible: false
modifier: MODEL1310110054#
name: g-glutamyltransferase (e)

metaR SCP22x
is version of: http://identifiers.org/ec-code/2.3.1.176
name: Sterol carrier protein 2
modifier: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
is: SBO:0000185
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#

metaR GULN3D
is: SBO:0000176
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
name: L-gulonate 3-dehydrogenase
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
fast: false
product: MODEL1310110054#
reversible: true

metaR GALT
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
is version of: http://identifiers.org/ec-code/2.7.7.12
is: SBO:0000176
product: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: true
reactant: MODEL1310110054#
name: galactose-1-phosphate uridylyltransferase
modifier: MODEL1310110054#

metaM nrpphr e
is: HMDB00216
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
name: Norepinephrine
is: CHEBI:33569
has only substance units: false
type: Species

metaR S6T17g
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110054#_2c0cf43e_099f_4748_8a22_84533417564d
has only substance units: false
initial concentration: NaN
is: Q96KH8
name: SLC6A2
is encoded by: hsa:6530
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

metaR ACACT5p
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
type: Reaction
reversible: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
reactant: MODEL1310110054#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110054#_51eec796_1d63_49ec_a53f_178032d72ea3
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
name: _AA177072_1_c
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:AA177072

metaR GBSIDEte
name: globoside transport
product: MODEL1310110054#
reactant: MODEL1310110054#
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110054#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - The goal of this transporter is to get globoside to the EC plasma membrane NJ

metaR ACGALtly
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false
product: MODEL1310110054#
kinetic law: MODEL1310110054#
name: N-acetyl-galactosamine lysosomal efflux
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
reactant: MODEL1310110054#
is: SBO:0000185

metaM core3 g
name: Core 3
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: CHEBI:16250
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_e2b74c79_f992_44af_a638_2c99b078774d
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5151
type: Species
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
name: PDE8A

metaR r1974
name: Y+LAT2 Utilized transport
modifier: MODEL1310110054#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110054#
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#

metaR GALU
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.9
reversible: true
fast: false
modifier: MODEL1310110054#
name: UTP-glucose-1-phosphate uridylyltransferase
product: MODEL1310110054#
is described by: ECO:0000134

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_71867ac2_8886_4ae4_b8a9_77e21fe1b7dd
type: Species
initial concentration: NaN
is: SBO:0000252
name: FBP1
has only substance units: false
boundary condition: true
is encoded by: hsa:2203
constant: false
is: Q2TU34
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_8180de43_44a6_4fa1_8dd5_dc7abaf7b069
constant: false
initial concentration: NaN
name: ATP2B3
is encoded by: hsa:492
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q16720

metaM ura c
is: HMDB00300
initial amount: NaN
is: CHEBI:17568
constant: false
initial concentration: 1.0
boundary condition: false
name: Uracil
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
has only substance units: false
type: Species
is: C00106
is: SBO:0000247

metaM ibcoa m
boundary condition: false
is: CHEBI:57338
has only substance units: false
initial amount: NaN
name: isobutyryl-CoA(4-)
constant: false
is: SBO:0000247
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
type: Species
is: HMDB01243
initial concentration: 1.0

metaM acgam1p c
type: Species
initial amount: NaN
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
initial concentration: 1.0
is: HMDB01367
name: N-Acetyl-D-glucosamine 1-phosphate
is: CHEBI:7125
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_543bbc7b_7630_46a1_94be_41ec77a9b361
is: SBO:0000297
is encoded by: hsa:8503
has part: A7E2E0
boundary condition: true
constant: false
type: Species
initial concentration: NaN
name: PIK3CD:PIK3R3
initial amount: NaN
has only substance units: false
has part: Q92569
is encoded by: hsa:5293

http://identifiers.org/biomodels.db/MODEL1310110054#_f585a81c_054f_404a_8c33_5c5eb050ca68
constant: false
initial amount: NaN
is encoded by: hsa:517
name: ATP5G2
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q06055

metaM dag hs c
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:18035
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
name: diglyceride
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR G13MT U
type: Reaction
reversible: false
is: SBO:0000176
fast: false
name: Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)
product: MODEL1310110054#
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.1.132
modifier: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD

metaR DNDPt11m
reactant: MODEL1310110054#
modifier: MODEL1310110054#
fast: false
is described by: ECO:0000269
product: MODEL1310110054#
name: dADP transport via dGDP antiport
kinetic law: MODEL1310110054#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185

metaM nadp m
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: CHEBI:58349
is: SBO:0000247
name: Nicotinamide adenine dinucleotide phosphate
type: Species
initial concentration: 1.0
has only substance units: false
is: C00006
is: HMDB00217

metaM nrpphr c
type: Species
initial concentration: 1.0
is: HMDB00216
constant: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: Norepinephrine
has only substance units: false
is: CHEBI:33569

metaM HC00342 c
initial concentration: 1.0
constant: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:16383
name: cis-aconitate(3-)

metaM Nacasp c
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: N-acetyl-L-aspartate(2-)
is: HMDB00812
constant: false
is: CHEBI:16953
has only substance units: false

metaM dectricoa m
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
constant: false
name: 2,4,7-decatrienoylcoa
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_24646138_517c_4d45_aa48_7b6674b1c823
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:6391
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is: Q99643
name: SDHC

metaR CITt4 2
reactant: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110054#
type: Reaction
name: citrate transport via sodium symport
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
fast: false
reversible: true
kinetic law: MODEL1310110054#

metaR r1823
fast: false
product: MODEL1310110054#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000185
kinetic law: MODEL1310110054#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110054#_8de7d5bd_02c3_4499_958a_f563ae55d5cd
is: SBO:0000252
is encoded by: hsa:5152
type: Species
has only substance units: false
name: PDE9A
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM pe hs e
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
is: CHEBI:16038
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species

metaM cdp m
constant: false
boundary condition: false
has only substance units: false
name: CDP(3-)
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: HMDB01546
is: CHEBI:58069
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_4014027a_5b84_44ac_91df_a2cb2c7a69c9
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
name: TPI1P2
initial concentration: NaN
is encoded by: hsa:286016

metaM arachd x
type: Species
name: arachidonate
constant: false
initial concentration: 1.0
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB01043
is: CHEBI:32395
boundary condition: false

metaR GCC2bim
fast: false
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110054#
reversible: false
is version of: http://identifiers.org/ec-code/1.8.1.4
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.4.4.2
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.1.2.10
type: Reaction
product: MODEL1310110054#

metaR PAIL4P HStn
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110054#
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)

metaR GLCAASE7ly
is: SBO:0000176
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
name: beta-glucuronidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: false
modifier: MODEL1310110054#
is described by: ECO:0000000
type: Reaction

metaR GCHOLAte
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
type: Reaction
reactant: MODEL1310110054#
name: bile acid intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_b4ca435e_bc4f_4cf9_a53d_5607a099f376
has only substance units: false
name: NDUFV3
is: SBO:0000252
type: Species
initial concentration: NaN
is: P56181
boundary condition: true
is encoded by: hsa:4731
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_metaR_EX_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_d5ccef35_5e6f_4550_92d2_4da37576e47e
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: ACOT2
is: P49753
is encoded by: hsa:10965
type: Species

metaR r0021
is described by: ECO:0000000
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.5
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
is: SBO:0000176
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
kinetic law: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
modifier: MODEL1310110054#

metaM h x
initial concentration: 1.0
is: C00080
type: Species
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
name: proton

metaR FAOXC163C142x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)x
type: Reaction

metaR A4GALTg
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.228
name: Lactosylceramide 4-alpha-galactosyltransferase
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
reversible: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_8f18dec9_9bd0_4a81_965d_c56b9aba4335
name: FTCD
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:10841
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true

metaR CITt4 4
is: SBO:0000185
product: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
is described by: ECO:0000006
name: citrate transport via sodium symport
fast: false
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
reversible: true
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_905835ad_8966_4f23_8760_3f2acd3f0260
initial amount: NaN
constant: false
name: _AL050025_1_c
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:AL050025

metaM nadp r
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate
is: SBO:0000247
is: HMDB00217
type: Species
is: CHEBI:58349
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: C00006
constant: false

metaR r0022
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110054#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is version of: http://identifiers.org/ec-code/1.8.1.7
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:

metaM ksi deg40 l
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
name: keratan sulfate I, degradation product 40
type: Species
is: HMDB00143
initial concentration: 1.0
initial amount: NaN
is: CHEBI:12936
notes: FORMULA: C40H68N2O31 CHARGE: 0

metaR EX leuleu LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylleucine
type: Reaction

metaM 4mptnl m
is: SBO:0000247
is: CHEBI:17998
constant: false
initial amount: NaN
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
name: 4-methylpentanal
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB01318
has only substance units: false

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaM aicar c
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01517
is: CHEBI:58475
initial amount: NaN
is: C04677
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
constant: false
has only substance units: false
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677

metaR r1109
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
reactant: MODEL1310110054#
is: SBO:0000176
fast: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110054#
type: Reaction
reversible: true

metaR UGCG
type: Reaction
product: MODEL1310110054#
is described by: ECO:0000000
name: Ceramide glucosyltransferase
reactant: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.80
is: SBO:0000176
kinetic law: MODEL1310110054#
reversible: false
fast: false

metaM thcrm hs g
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: trihexosyl ceramide
constant: false
initial amount: NaN
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
type: Species
is: SBO:0000247
is: CHEBI:24636

http://identifiers.org/biomodels.db/MODEL1310110054#_e074ca02_3b80_4456_8306_b21b9e497a2e
initial amount: NaN
has only substance units: false
is: D3DWC4
constant: false
is: SBO:0000252
is encoded by: hsa:259230
boundary condition: true
type: Species
initial concentration: NaN
name: SGMS1

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaR GALASE16ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110054#
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal

metaR FUCASEe
is described by: ECO:0000000
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.51
reversible: false
fast: false
name: alpha-fucosidase, extracellular
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110054#
type: Reaction
is: SBO:0000176

metaM cdp n
name: CDP(3-)
has only substance units: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
boundary condition: false
type: Species
initial amount: NaN
is: HMDB01546
is: SBO:0000247
is: CHEBI:58069
constant: false
initial concentration: 1.0

metaM n2m2nm l
boundary condition: false
initial amount: NaN
name: n2m2nmasn (w/o peptide linkage)
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:36033
is: HMDB02177
notes: FORMULA: C58H97N5O41 CHARGE: 0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_9e649155_16b8_4132_a0e2_15993ee15ef6
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:34
has only substance units: false
constant: false
type: Species
is: P11310
boundary condition: true
name: ACADM

metaM grdp x
constant: false
name: geranyl diphosphate(3-)
has only substance units: false
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
is: CHEBI:58057
initial amount: NaN
type: Species
boundary condition: false
is: HMDB01285
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_d9b2bf49_8c40_4ae6_b800_3d73a618d4b3
name: PNPLA3
is: SBO:0000252
boundary condition: true
is: Q9NST1
is encoded by: hsa:80339
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_2798a3bc_51f3_4810_b9f7_8651be574419
initial amount: NaN
is: Q86YN1
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: DOLPP1
constant: false
has only substance units: false
type: Species
is encoded by: hsa:57171

http://identifiers.org/biomodels.db/MODEL1310110054#_782ee975_434f_4ad2_a4a4_4cad26c6716b
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:56922
is: SBO:0000252
is: Q96RQ3
type: Species
initial concentration: NaN
boundary condition: true
name: MCCC1

http://identifiers.org/biomodels.db/MODEL1310110054#_6add5f2c_adc5_4ae5_bbdd_45658975db78
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:1854
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: DUT
type: Species
is: P33316

http://identifiers.org/biomodels.db/MODEL1310110054#_b3de160a_8930_4483_8126_5bf58380d83a
is: P07203
type: Species
has only substance units: false
is: SBO:0000252
name: GPX1
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:2876
boundary condition: true

metaR MI145PK
is version of: http://identifiers.org/ec-code/2.7.1.127
modifier: MODEL1310110054#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110054#
fast: false
reversible: false
reactant: MODEL1310110054#
name: inositol-1,4,5-trisphosphate 3-kinase
kinetic law: MODEL1310110054#

metaR G12MT2 L
product: MODEL1310110054#
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
reversible: false
kinetic law: MODEL1310110054#
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)

http://identifiers.org/biomodels.db/MODEL1310110054#_98ae7271_1a11_431f_b333_f914ad178d61
initial concentration: NaN
constant: false
is: Q9UMR5
is: SBO:0000252
name: PPT2
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:9374

metaR FUT14g
is: SBO:0000176
modifier: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
reactant: MODEL1310110054#
name: Galactoside 2-alpha-L-fucosyltransferase 1
is described by: ECO:0000269
fast: false
product: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.69

http://identifiers.org/biomodels.db/MODEL1310110054#_c0efd09e_8190_4c2e_8777_166a4e32bf44
type: Species
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:123041
name: SLC24A4
initial amount: NaN

metaR O2tm
fast: false
product: MODEL1310110054#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110054#
is described by: ECO:0000000
reversible: true
name: O2 transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
kinetic law: MODEL1310110054#

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

metaR r2384
fast: false
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
modifier: MODEL1310110054#
type: Reaction

metaM malthp e
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: C01936
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5041
constant: false
type: Species
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
has only substance units: false
name: maltoheptaose

metaR TYRt
modifier: MODEL1310110054#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
name: L-tyrosine transport
type: Reaction
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_8c5875fb_41bb_49c5_ac0a_9af75d9ff844
is: O43306
initial concentration: NaN
is encoded by: hsa:112
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: ADCY6
type: Species
boundary condition: true

metaM 3mox4hpac m
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
boundary condition: false
is: CHEBI:28111
is: SBO:0000247
is: HMDB05175
has only substance units: false

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaM h l
is: SBO:0000247
is: C00080
has only substance units: false
type: Species
name: proton
constant: false
boundary condition: false
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: "
initial amount: NaN

metaR XYLt
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
is described by: ECO:0000269
name: D-xylose reversible transport
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
product: MODEL1310110054#
reversible: true
fast: false
is: SBO:0000185
modifier: MODEL1310110054#

metaR GALK
is described by: ECO:0000000
type: Reaction
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.1.157
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.1.6
kinetic law: MODEL1310110054#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
modifier: MODEL1310110054#
name: galactokinase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_75b02c6e_5893_4f3f_9723_de8f17f9f0f9
type: Species
initial amount: NaN
is encoded by: hsa:8818
initial concentration: NaN
name: DPM2
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaR r0178
fast: false
is version of: http://identifiers.org/ec-code/2.5.1.21
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000000
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
modifier: MODEL1310110054#
reversible: true
is: SBO:0000176
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
type: Reaction

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_3b579f6c_7139_4496_93e0_9b311e06c174
is encoded by: hsa:374291
initial amount: NaN
type: Species
is: O75251
has only substance units: false
is: SBO:0000252
constant: false
name: NDUFS7
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_3acf4329_ff28_4b09_9b6c_c704fc523cab
type: Species
boundary condition: true
is: SBO:0000252
is: Q75T13
constant: false
has only substance units: false
is encoded by: hsa:80055
name: PGAP1
initial amount: NaN
initial concentration: NaN

metaR r2385
kinetic law: MODEL1310110054#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110054#
is described by: ECO:0000000
modifier: MODEL1310110054#
reactant: MODEL1310110054#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110054#_f0c19371_7cba_48da_a488_86a07b399230
has only substance units: false
is encoded by: hsa:6240
is: P23921
name: RRM1
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
constant: false

metaM pe hs c
name: phosphatidylethanolamine
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16038
type: Species
boundary condition: false
constant: false

metaR FAOXC80
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000269
name: Beta oxidation of med/long chain fatty acid
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
modifier: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
type: Reaction
reactant: MODEL1310110054#

metaM sphs1p c
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB00277
boundary condition: false
constant: false
is: CHEBI:60119
name: sphingosine 1-phosphate(1-)
is: SBO:0000247
type: Species

metaR r1540
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110054#
is: SBO:0000185
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
kinetic law: MODEL1310110054#
fast: false
modifier: MODEL1310110054#
reversible: false
is described by: ECO:0000000
type: Reaction

metaR r0179
is version of: http://identifiers.org/ec-code/1.1.1.27
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110054#
fast: false
is: SBO:0000176
product: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
reactant: MODEL1310110054#

metaM mn l
constant: false
has only substance units: false
boundary condition: false
type: Species
is: HMDB06535
initial concentration: 1.0
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
is: SBO:0000247
name: beta-1,4-mannose-N-acetylglucosamine
initial amount: NaN

metaM h m
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/3380
is: C00080
constant: false
type: Species
name: proton
is: CHEBI:24636
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_39d86d51_62c1_4e36_8681_7de78dfd4537
initial concentration: NaN
type: Species
is encoded by: hsa:220
initial amount: NaN
is: P47895
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
name: ALDH1A3

metaR r1259
reactant: MODEL1310110054#
fast: false
reversible: false
is: SBO:0000176
is described by: ECO:0000000
name: EC:6.2.1.3
product: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110054#_58e396d3_263e_4b61_9841_31a3a686649d
boundary condition: true
has only substance units: false
name: ST3GAL3
initial amount: NaN
is encoded by: hsa:6487
is: SBO:0000252
is: B4DX62
constant: false
type: Species
initial concentration: NaN

metaM lald L c
is: CHEBI:18041
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
name: (S)-lactaldehyde
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: HMDB03052
initial concentration: 1.0

metaR r2386
product: MODEL1310110054#
reactant: MODEL1310110054#
reversible: false
kinetic law: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
modifier: MODEL1310110054#
is: SBO:0000185
type: Reaction

metaR EICOSTETt
fast: false
type: Reaction
is described by: ECO:0000000
name: fatty acid transport via diffusion
is: SBO:0000185
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110054#

metaM 5dpmev x
boundary condition: false
initial amount: NaN
is: CHEBI:15899
is: HMDB01090
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00685 EHMN_ABBREVIATION: C01143
type: Species
name: (R)-5-Diphosphomevalonate
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_9482fef7_7f33_443c_a6b7_21f6e8dd0278
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
name: ACSL1
type: Species
is encoded by: hsa:2180
is: P33121
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_48f171c5_f236_47e1_b3a0_913bd249f86b
is: P38571
initial concentration: NaN
constant: false
is encoded by: hsa:3988
name: LIPA
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_7369df5c_61d7_43f4_9d0e_91cd72a2eb79
constant: false
is encoded by: hsa:376497
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
name: SLC27A1
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_43cead19_7fbe_4ae5_9029_19a4d0d862f5
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: P32929
has only substance units: false
is encoded by: hsa:1491
is: SBO:0000252
name: CTH

metaR r0027
product: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
fast: false
kinetic law: MODEL1310110054#
type: Reaction
reversible: true
reactant: MODEL1310110054#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.39
modifier: MODEL1310110054#
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9

http://identifiers.org/biomodels.db/MODEL1310110054#_61568bc9_6891_4b2b_8fde_f730900571b7
is: SBO:0000252
type: Species
constant: false
name: SKIV2L2
is encoded by: hsa:23517
has only substance units: false
initial concentration: NaN
is: Q3MHC9
boundary condition: true
initial amount: NaN

metaM h n
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
has only substance units: false
type: Species
constant: false
is: CHEBI:24636
name: proton
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_3584c65a_18b1_4264_b91a_19b5d3b7d6f5
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:2544
name: _2544_1_c
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaR STRDNCCOAtxc
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of stearidonylcoa into peroxisomes.
type: Reaction

metaR r0308
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
is: SBO:0000176
type: Reaction
reactant: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_a95cabc9_2253_4910_b79e_9bfc04c60e48
boundary condition: true
name: MAN2B1
initial concentration: NaN
has only substance units: false
type: Species
is: O00754
is: SBO:0000252
constant: false
is encoded by: hsa:4125
initial amount: NaN

metaR FK
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
is: SBO:0000176
reversible: false
modifier: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.52
product: MODEL1310110054#
name: Fucokinase
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_bd2ff524_2668_4d56_8b7a_01ef2b5ab641
constant: false
name: CHAT
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q6LEN6
is encoded by: hsa:1103
is: SBO:0000252
type: Species

metaM CE5125 x
boundary condition: false
is: CHEBI:15748
is: HMDB00127
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5125
name: (2S)-pristanoyl-CoA
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_ec92b7c3_932b_49e1_92ed_93502218a430
constant: false
type: Species
is encoded by: hsa:56922
boundary condition: true
initial amount: NaN
has part: Q9HCC0
has only substance units: false
is encoded by: hsa:64087
initial concentration: NaN
has part: Q96RQ3
name: MCCC1:MCCC2
is: SBO:0000297

metaR r0173
kinetic law: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: (3704.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:12042361,PMID:17045662,PMID:7449128,PMID:9927705 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110054#
name: (S)-Lactate:NAD+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.1.1.27
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.19
modifier: MODEL1310110054#

metaM 44mctr r
has only substance units: false
constant: false
is: CHEBI:17813
is: HMDB01023
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
type: Species
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_c8a7176b_141a_48e9_8f18_54e62e317a8a
is: Q53Y83
has only substance units: false
name: GLA
is encoded by: hsa:2717
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species

metaM gln L m
has only substance units: false
initial concentration: 1.0
is: HMDB00641
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
initial amount: NaN
name: L-glutamine
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:18050

metaM r1p c
has only substance units: false
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
name: alpha-D-Ribose 1-phosphate
initial concentration: 1.0
boundary condition: false
is: HMDB01489
is: C00442
is: CHEBI:57720
type: Species
initial amount: NaN
is: SBO:0000247
constant: false

metaM cdp e
type: Species
boundary condition: false
is: HMDB01546
is: CHEBI:58069
constant: false
name: CDP(3-)
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_71aaa2a3_cd66_4ed1_b507_e0fc89fb6614
name: SGPP1
constant: false
is: Q9BX95
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:81537
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species

metaR TDCHOLAtx
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
type: Reaction
reversible: true
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
product: MODEL1310110054#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110054#_d98162da_b4f8_43d7_979d_f8ff1805ca82
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:514
constant: false
is encoded by: hsa:513
initial amount: NaN
is: SBO:0000297

metaM ade c
is: C00147
name: Adenine
is: SBO:0000247
constant: false
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00034
is: CHEBI:16708

http://identifiers.org/biomodels.db/MODEL1310110054#_2f0e201f_13fa_4b02_ad9b_619fce326ba4
is: O94903
is encoded by: hsa:11212
type: Species
initial amount: NaN
constant: false
name: PROSC
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM doldp U r
boundary condition: false
notes: FORMULA: C1025H1670O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
constant: false
has only substance units: false
name: Dolichol diphosphate, human uterine homolog
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15750
type: Species

metaR r2380
reversible: true
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
fast: false
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110054#
product: MODEL1310110054#

metaR GALASE6ly
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
product: MODEL1310110054#
name: beta-galactosidase, lysosomal
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110054#_ff977506_219a_4729_b8d8_278c1846b901
has only substance units: false
name: COX3
is: P00414
is encoded by: hsa:4514
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_8a21a05c_b9d4_4e6c_8bbb_4ce7fcf3a699
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
name: _AI631997_1_m
is encoded by: hsa:AI631997

http://identifiers.org/biomodels.db/MODEL1310110054#_3c0959e1_3c81_4860_bf58_8ad0b508da24
is encoded by: hsa:56953
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is: Q9NPB1
name: NT5M
type: Species

metaR FAOXC200180m
reversible: false
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction

metaR KSII CORE4tly
product: MODEL1310110054#
reversible: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: keratan sulfate II (core 4) transport, extracellular to lysosome
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR THMMPtm
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
name: Thiamine monophosphate transport, mitochondrial
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12014993,PMID:9755848 NOTES:IT
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_bdae7abd_cefe_4d45_a795_2c3adc1fb197
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
is: Q4G1C4
name: ZADH2
has only substance units: false
is encoded by: hsa:284273
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_c0244b0a_0e9a_478d_b14d_6308e7de47ec
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
name: _AA203143_1_c
is: SBO:0000252
is encoded by: hsa:AA203143
type: Species
boundary condition: true

metaR GBSIDEtl
kinetic law: MODEL1310110054#
reversible: true
product: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) NJ
name: globoside intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110054#_888cb41c_e038_4c29_a47e_f40fea0c9a6d
constant: false
is: SBO:0000252
is encoded by: hsa:1103
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: CHAT
type: Species
boundary condition: true
is: Q6LEN5

http://identifiers.org/biomodels.db/MODEL1310110054#_dec464ba_6879_4f99_9715_aad077a854d2
is: Q9BQL0
name: BCKDHB
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:594
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_46018e5f_c6c6_42fc_ab6e_2dfcdf300577
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
name: _AI924226_1_m
type: Species
is encoded by: hsa:AI924226

metaR r0739
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:
modifier: MODEL1310110054#
is described by: ECO:0000000
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1
type: Reaction
fast: false
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#

metaR NODe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110054#
name: NODe
is described by: ECO:0000134
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000185
type: Reaction
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_202a27a9_7ef5_43c2_8f4f_9678540f931f
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
name: _U37519_1_m
is encoded by: hsa:U37519
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_0dc0a74c_1c59_4827_8535_9c0910514c60
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:AA854479
boundary condition: true
initial amount: NaN
name: _AA854479_1_m

metaR O2tp
name: O2 transport, peroxisomal
is: SBO:0000185
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110054#
kinetic law: MODEL1310110054#

metaM f6p c
name: D-Fructose 6-phosphate
initial concentration: 1.0
is: HMDB00124
constant: false
is: CHEBI:57579
is: C00085
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3385
boundary condition: false

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaR r1544
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110054#
is: SBO:0000185
kinetic law: MODEL1310110054#

metaM ade e
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
initial amount: NaN
name: adenine
is: HMDB00034
has only substance units: false
boundary condition: false
is: CHEBI:16708

metaM m5masnB2 g
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: HMDB02985
has only substance units: false
is: CHEBI:58433
notes: FORMULA: C52H87N2O40X CHARGE: 0
initial concentration: 1.0
type: Species
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

metaR FAOXC102C81m
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

metaM ksi pre29 g
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 29
has only substance units: false
is: CHEBI:28067
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
type: Species
is: SBO:0000247
initial amount: NaN
constant: false

metaM h r
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: C00080
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: proton

http://identifiers.org/biomodels.db/MODEL1310110054#_4bf91ca2_4be2_4401_ae7e_00cd9b67294a
has only substance units: false
has part: Q9NS82
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
has part: P08195
type: Species
is encoded by: hsa:56301
boundary condition: true
is encoded by: hsa:6520
name: SLC7A10:SLC3A2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_26b1c713_74e1_4044_80ff_75e80e0cb52c
is encoded by: hsa:AV717590
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: _AV717590_1_c

metaR RE1233C
is described by: ECO:0000000
fast: false
name: RE1233
reversible: true
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.6.1.64
type: Reaction
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110054#_9277a4cd_c340_4c92_ae85_4ca3e2be18fa
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: MGAT2
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:4247
type: Species
is: Q10469

metaR r2382
kinetic law: MODEL1310110054#
is: SBO:0000185
fast: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110054#
reversible: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110054#
type: Reaction

metaM cholcoa c
is: HMDB01374
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57373
type: Species
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
name: choloyl-CoA(4-)
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR r1864
modifier: MODEL1310110054#
is: SBO:0000185
name: Y+LAT2 Utilized transport
product: MODEL1310110054#
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR GLCURtly
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110054#
product: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000185
kinetic law: MODEL1310110054#
name: glucuronate transport into lysososme
fast: false
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
type: Reaction

metaR O2tn
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
fast: false
product: MODEL1310110054#
reversible: true
is: SBO:0000185
reactant: MODEL1310110054#
is described by: ECO:0000000
name: O2 nuclear transport

http://identifiers.org/biomodels.db/MODEL1310110054#_6dcad99e_d05e_4dfd_a088_6a38e3e8f390
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:54407
name: SLC38A2
has only substance units: false
is: Q96QD8
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_9bf5628a_061d_4e02_8cdf_47c803d20b52
constant: false
is encoded by: hsa:1962
is: Q9NY65
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: EHHADH

metaR S6TASE25ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110054#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.23
name: galactose-6-sulfate sulfatase, lysosomal
is: SBO:0000176
fast: false

metaR EX ksi deg1 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I, degradation product 1 exchange
type: Reaction

metaR FAOXC16OHC16r
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

metaR r1559
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110054#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_c70731cf_d0d9_4be0_8983_22f4302bff91
type: Species
is: Q9NRA2
initial concentration: NaN
is encoded by: hsa:26503
is: SBO:0000252
has only substance units: false
name: SLC17A5
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_fa8ccecc_b8ba_4b7f_8fea_96586aec0b3a
is: SBO:0000252
type: Species
initial amount: NaN
is: O60762
initial concentration: NaN
name: DPM1
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:8813

http://identifiers.org/biomodels.db/MODEL1310110054#_dce00c8b_3cb5_47d1_bcd4_1c7fe74146ed
is encoded by: hsa:5281
boundary condition: true
name: PIGF:PIGO
is encoded by: hsa:84720
is: SBO:0000297
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
has part: Q6IB04

metaM ocdcea e
is: C00712
notes: FORMULA: C18H33O2 CHARGE: -1
has only substance units: false
is: CHEBI:0
constant: false
boundary condition: false
is: HMDB00207
type: Species
initial amount: NaN
name: octadecenoate (n-C18:1)
initial concentration: 1.0
is: SBO:0000247

metaM dcmp n
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB01202
boundary condition: false
constant: false
is: CHEBI:57566
name: dCMP(2-)
initial concentration: 1.0
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239

metaR PI34P5K
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
reversible: false
kinetic law: MODEL1310110054#
is described by: ECO:0000000
reactant: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.1.68
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110054#
fast: false

metaM m6masnB2 g
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C58H97N2O45X CHARGE: 0
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:36033
is: HMDB02177

metaR HMGLm
type: Reaction
fast: false
kinetic law: MODEL1310110054#
is: SBO:0000176
modifier: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/4.1.3.4
is described by: ECO:0000134
reactant: MODEL1310110054#
name: hydroxymethylglutaryl-CoA lyase
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
reversible: false

metaM h e
is: http://identifiers.org/pubchem.compound/3380
name: proton
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: "
has only substance units: false
initial concentration: 1.0
is: C00080
constant: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN

metaM f1a g
is: CHEBI:15936
name: F1alpha
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C22H37N2O15X CHARGE: 0
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0

metaR r2369
product: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
fast: false
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is: SBO:0000185

metaM arachd e
boundary condition: false
is: HMDB01043
initial amount: NaN
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
name: arachidonate
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:32395
type: Species

metaM tyr L e
boundary condition: false
type: Species
constant: false
name: L-tyrosine
is: CHEBI:17895
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00158
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: SBO:0000247

metaM HC02202 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
boundary condition: false
is: CHEBI:57398
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
name: prostaglandin A1(1-)

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

metaM HC00250 e
has only substance units: false
is: CHEBI:29919
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
boundary condition: false
is: SBO:0000247
type: Species
name: hydrosulfide
constant: false
initial concentration: 1.0
initial amount: NaN

metaM cmpacna n
type: Species
is: HMDB01176
constant: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:57812
name: CMP-N-acetyl-beta-neuraminate(2-)
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_3a5e731f_6141_40c5_9261_b34a48e95bdb
initial amount: NaN
constant: false
is encoded by: hsa:AW299740
is: SBO:0000252
name: _AW299740_1_m
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true

metaM pyr m
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: C00022
type: Species
is: http://identifiers.org/pubchem.compound/3324
initial concentration: 1.0
name: pyruvate
is: CHEBI:15361
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00243

http://identifiers.org/biomodels.db/MODEL1310110054#_39e29f29_4106_4470_9f06_a04f0f6ca290
is encoded by: hsa:112724
boundary condition: true
is: B3KVA3
name: RDH13
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_b5b7791a_c847_41fd_88c3_621477096788
initial concentration: NaN
is: SBO:0000252
is: P48448
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:222
boundary condition: true
type: Species
name: ALDH3B2

metaR THMP
reactant: MODEL1310110054#
product: MODEL1310110054#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD
is described by: ECO:0000000
name: thiamin phosphatase
reversible: false
type: Reaction
kinetic law: MODEL1310110054#

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_dbfc4551_9716_49e3_91ab_0487d59c6451
type: Species
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
name: PC
is: P11498
is: SBO:0000252
is encoded by: hsa:5091

metaR r0587
type: Reaction
modifier: MODEL1310110054#
fast: false
reversible: true
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000176
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
product: MODEL1310110054#

metaM pan4p e
has only substance units: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2
type: Species
is: HMDB01416
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:47942
initial amount: NaN
is: C01134
name: Pantetheine 4'-phosphate
boundary condition: false
constant: false

metaM CE5867 e
is: HMDB02710
is: CHEBI:27485
has only substance units: false
constant: false
name: N-acetyl-seryl-aspartyl-lysyl-proline
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H32N5O9 CHARGE: -1 INCHI: InChI=1/C20H33N5O9/c1-11(27)22-14(10-26)18(31)24-13(9-16(28)29)17(30)23-12(5-2-3-7-21)19(32)25-8-4-6-15(25)20(33)34/h12-15,26H,2-10,21H2,1H3,(H,22,27)(H,23,30)(H,24,31)(H,28,29)(H,33,34)/p-1/t12-,13+,14-,15-/m0/s1 EHMN_ABBREVIATION: CE5867
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_69db409f_a3de_4cb4_b1a0_f0a1e2c1f399
is encoded by: hsa:8310
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: ACOX3
has only substance units: false
type: Species
is: O15254

http://identifiers.org/biomodels.db/MODEL1310110054#_c55857d2_b2bf_4f1d_b27f_f53ce8068867
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q6PCB7
is encoded by: hsa:376497
type: Species
name: SLC27A1
constant: false
initial concentration: NaN

metaR r2368
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
product: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_d8a1aad6_a0a4_4f16_a86f_025d5783df52
initial concentration: NaN
is encoded by: hsa:1650
constant: false
is encoded by: hsa:1603
boundary condition: true
name: DAD1:DDOST:RPN1:RPN2
is encoded by: hsa:6185
has part: Q53G02
is encoded by: hsa:6184
is: SBO:0000297
has only substance units: false
has part: P39656
type: Species
initial amount: NaN
has part: P04843
has part: P04844

metaM galgluside hs c
is: HMDB06535
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: galactosyl glucosyl ceramide
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
constant: false
has only substance units: false

metaR r1557
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110054#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_41bfec3a_925c_4ee6_b8d1_79fe4089563d
boundary condition: true
is: Q14916
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6568
constant: false
is: SBO:0000252
name: SLC17A1
has only substance units: false

metaR r0170
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.1.40
type: Reaction
fast: false
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
modifier: MODEL1310110054#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
is: SBO:0000176
product: MODEL1310110054#

metaR LEUKTRE4t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
name: leukotriene E4 transport
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
product: MODEL1310110054#
fast: false

metaM ocdcea c
constant: false
type: Species
is: C00712
is: HMDB00207
is: CHEBI:0
notes: FORMULA: C18H33O2 CHARGE: -1
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: octadecenoate (n-C18:1)

http://identifiers.org/biomodels.db/MODEL1310110054#_bcdeb3c1_e5f9_4e6a_b3a7_788b40b28854
is: P48426
constant: false
is: SBO:0000252
type: Species
name: PIP4K2A
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5305

metaM 4mzym int2 r
boundary condition: false
type: Species
name: 4-Methylzymosterol intermediate 2
has only substance units: false
constant: false
is: HMDB06838
is: SBO:0000247
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_9700969b_5598_4843_a510_4ce2411f9a2f
initial concentration: NaN
is: Q5VYT2
name: NDUFB6
constant: false
initial amount: NaN
is encoded by: hsa:4712
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252

metaM h c
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: "
constant: false
initial concentration: 1.0
is: SBO:0000247
name: proton
type: Species
is: C00080
has only substance units: false
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
boundary condition: false

metaR r2367
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110054#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110054#
reversible: true
is described by: ECO:0000000
product: MODEL1310110054#

metaM arachd c
is: HMDB01043
name: arachidonate
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
initial concentration: 1.0
is: CHEBI:32395
has only substance units: false

metaM HC00250 c
initial amount: NaN
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: CHEBI:29919
boundary condition: false
is: SBO:0000247
name: hydrosulfide
type: Species
initial concentration: 1.0
constant: false
has only substance units: false

metaR FE2tm
fast: false
product: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
name: iron (II) transport
is: SBO:0000185
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10383398,PMID:12755454 NOTES:TDV Lange H, 1999.
type: Reaction

metaR PROSTGF2t
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
product: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
name: prostaglandin uniport
kinetic law: MODEL1310110054#
is described by: ECO:0000269

metaR GARFT
is described by: ECO:0000269
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
reversible: true
type: Reaction
modifier: MODEL1310110054#
fast: false
name: phosphoribosylglycinamide formyltransferase
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.1.2.2
is: SBO:0000176
reactant: MODEL1310110054#

metaM 2hexdtetcoa x
name: 2,7,10,13-hexadecatetraenoylcoa
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB02288
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
constant: false

metaM tyr L c
boundary condition: false
name: L-tyrosine
is: SBO:0000247
type: Species
constant: false
is: CHEBI:17895
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial amount: NaN
is: HMDB00158

metaM 4mptnl c
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:17998
has only substance units: false
name: 4-methylpentanal
is: HMDB01318
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_d867d124_c38a_4128_87cb_4078405e11ad
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:4833
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: NME4
is: O00746

http://identifiers.org/biomodels.db/MODEL1310110054#_2350fb60_436f_4952_ba59_597eb7fcd0f2
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AL525798
name: _AL525798_1_c

metaM HC01434 m
initial concentration: 1.0
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
type: Species
is: CHEBI:58931
name: oxalatosuccinate(3-)
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR RE2426C
reversible: true
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
name: RE2426

metaR ITCOALm
product: MODEL1310110054#
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.5
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.4
reversible: true
is described by: ECO:0000212
reactant: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD

metaR ORPT
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.2.10
reactant: MODEL1310110054#
name: orotate phosphoribosyltransferase
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
product: MODEL1310110054#
is described by: ECO:0000269

metaR SMPD3g
product: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
kinetic law: MODEL1310110054#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
reversible: false
fast: false
is: SBO:0000176
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.1.4.12

metaM lys L c
is: HMDB00182
has only substance units: false
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:32551
constant: false
initial concentration: 1.0
name: L-lysinium(1+)

metaM ksii core2 pre9 g
type: Species
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 9
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28067

http://identifiers.org/biomodels.db/MODEL1310110054#_67c21711_4ba8_43a3_9559_07a199379a9a
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:55568
initial concentration: NaN
is: Q86SR1
constant: false
name: GALNT10
initial amount: NaN
type: Species

metaM prostgd2 e
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: CHEBI:57406
type: Species
name: prostaglandin D2(1-)
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB01403
has only substance units: false
boundary condition: false

metaM f1a l
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C22H37N2O15X CHARGE: 0
boundary condition: false
name: F1alpha
type: Species
is: CHEBI:15936
has only substance units: false
is: SBO:0000247

metaR PPAt
kinetic law: MODEL1310110054#
fast: false
product: MODEL1310110054#
name: Propionate transport, diffusion
reversible: false
reactant: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
is: SBO:0000185
type: Reaction

metaR r0584
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
modifier: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
kinetic law: MODEL1310110054#
is: SBO:0000176
is described by: ECO:0000000
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
fast: false

metaR r0756
is version of: http://identifiers.org/ec-code/3.1.3.1
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
reactant: MODEL1310110054#
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110054#
reversible: true

metaR r2366
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110054#
is: SBO:0000185
reversible: true
reactant: MODEL1310110054#
name: Organic anion transporter 5 Utilized transport
fast: false

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR RE2972M
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reversible: true
modifier: MODEL1310110054#
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.1.67
kinetic law: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
name: RE2972

metaM thmpp c
constant: false
initial concentration: 1.0
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
name: Thiamine diphosphate
is: HMDB01372
is: C00068
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:45931

metaR PROSTGI2t
product: MODEL1310110054#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110054#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
name: Prostaglandin I2 transport

metaM chol n
has only substance units: false
type: Species
is: HMDB00097
name: choline
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15354
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114

http://identifiers.org/biomodels.db/MODEL1310110054#_d78250c3_6644_4518_90ca_c8ea50dc581d
name: ELOVL1
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:64834
boundary condition: true
is: Q9BW60
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR LGTHL
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.4.1.5
reversible: false
name: lactoylglutathione lyase
modifier: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF
product: MODEL1310110054#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110054#_e15f5317_cc21_4ca5_9bc0_9937addd0636
is: O95299
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4705
name: NDUFA10
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_b992a63c_fccc_4eec_a50e_c03da189917c
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:AU149534
name: _AU149534_1_m
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN

metaR ASNALANaEx
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000269
fast: false
name: L-alanine/L-asparagine Na-dependent exchange (Asn-L in)
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_24e3a461_602f_4d33_81ad_dfa1e6884514
has only substance units: false
boundary condition: true
is encoded by: hsa:27068
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: PPA2

metaR r0755
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
type: Reaction
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
fast: false
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110054#
is: SBO:0000176
product: MODEL1310110054#

metaR LTC4CP
kinetic law: MODEL1310110054#
product: MODEL1310110054#
name: Leukotriene C4 carboxypeptidase
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
fast: false
is: SBO:0000176
reactant: MODEL1310110054#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_729983d6_c96d_433e_ba76_e8abba6d5342
is: SBO:0000252
initial amount: NaN
name: HAGHL
boundary condition: true
is encoded by: hsa:84264
constant: false
type: Species
is: Q6PII5
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_a415a8fc_c9ac_4f36_8c5b_056b3d2e08fb
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ADH6
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:130
is: P28332

metaR r2365
reversible: true
product: MODEL1310110054#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110054#
name: Organic anion transporter 5 Utilized transport
fast: false
kinetic law: MODEL1310110054#

metaR r0860
modifier: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110054#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/4.1.2.27
reactant: MODEL1310110054#
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110054#_ff583309_9632_4be0_b00d_8c1655aac358
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
name: B3GNT7
is: Q8NFL0
type: Species
boundary condition: true
is encoded by: hsa:93010

http://identifiers.org/biomodels.db/MODEL1310110054#_e886e4de_4cbc_4ecc_8c95_cfa4511a4b23
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
name: MBOAT2
is encoded by: hsa:129642
is: Q6ZWT7
has only substance units: false
initial amount: NaN
constant: false

metaM acetol c
is: HMDB06961
is: CHEBI:27957
name: hydroxyacetone
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaR GALASE17ly
type: Reaction
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110054#_a1dd01ab_b23b_4405_91fb_23cfdfd3f330
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:10840
has only substance units: false
type: Species
initial concentration: NaN
is: O75891
name: ALDH1L1
boundary condition: true

metaR LINKDEG1ly
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110054#
name: degradation of proteoglycan linkage region, lysosomal
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
reversible: false

metaR MI145PP
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
type: Reaction
reactant: MODEL1310110054#
is: SBO:0000176
product: MODEL1310110054#
reversible: false
modifier: MODEL1310110054#
is described by: ECO:0000269
fast: false
name: inositol-1,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.36
kinetic law: MODEL1310110054#

metaM galgluside hs g
name: galactosyl glucosyl ceramide
is: CHEBI:58223
type: Species
is: C00015
boundary condition: false
is: SBO:0000247
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
initial concentration: 1.0
is: HMDB00295
initial amount: NaN
has only substance units: false
constant: false

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaM chol m
boundary condition: false
is: HMDB00097
has only substance units: false
initial amount: NaN
is: CHEBI:15354
is: SBO:0000247
type: Species
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
initial concentration: 1.0
name: choline

metaR CYTK10n
kinetic law: MODEL1310110054#
is: SBO:0000176
reversible: true
reactant: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110054#
name: cytidylate kinase (CMP,dGTP),nuclear
type: Reaction
fast: false
is described by: ECO:0000269

metaR r2364
fast: false
reactant: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110054#
name: Organic anion transporter 5 Utilized transport
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110054#

metaM man g
is: CHEBI:16024
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00169
type: Species
constant: false
name: D-mannose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: SBO:0000247

metaM HC00342 m
name: cis-aconitate(3-)
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
constant: false
initial amount: NaN
is: CHEBI:16383
boundary condition: false
initial concentration: 1.0

metaM arab L c
boundary condition: false
name: L-arabinose
is: HMDB00646
notes: FORMULA: C5H10O5 CHARGE: 0
is: CHEBI:30849
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_0e50f8b1_0a20_4fdd_8a08_4db8bc7e107f
is encoded by: hsa:59272
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
name: ACE2
type: Species
is: C7ECU1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_e11ba5f3_e112_474d_bac4_aa3e3452aad5
has only substance units: false
is encoded by: hsa:55907
boundary condition: true
type: Species
is: Q8NFW8
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
name: CMAS

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_43575d7f_7d24_489d_a995_9c40dec64fd0
initial amount: NaN
is encoded by: hsa:4714
initial concentration: NaN
is: SBO:0000252
is: O95169
has only substance units: false
boundary condition: true
constant: false
type: Species
name: NDUFB8

metaR 3SPYRSPm
reversible: false
reactant: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
product: MODEL1310110054#
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
fast: false
is: SBO:0000176
is described by: ECO:0000000

metaM h g
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM xoltriol c
boundary condition: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
constant: false
is: CHEBI:16496
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB01457

metaR SUCCtp
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
name: succinate transporter, peroxisome
kinetic law: MODEL1310110054#
reversible: true
product: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#

metaR r2363
reversible: true
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110054#
fast: false
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_6c051b30_ed96_4450_ac7f_55dc2b6295e1
is: SBO:0000252
initial concentration: NaN
name: SLC17A4
is encoded by: hsa:10050
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: Q9Y2C5

metaR r0757
type: Reaction
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is version of: http://identifiers.org/ec-code/3.5.4.16
fast: false
is described by: ECO:0000000
reactant: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
reversible: true
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
product: MODEL1310110054#

metaM 5pmev x
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00670 EHMN_ABBREVIATION: C01107
name: (R)-5-phosphonatomevalonate(3-)
is: SBO:0000247
is: HMDB01343
type: Species
is: CHEBI:58146
initial concentration: 1.0

metaM alpam m
initial amount: NaN
is: HMDB06239
name: S-aminomethyldihydrolipoamide
has only substance units: false
boundary condition: false
type: Species
constant: false
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_metaR_EX_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIA glycolipid exchange
type: Reaction

metaM thymd c
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
constant: false
is: CHEBI:17748
type: Species
name: Thymidine
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00273
is: SBO:0000247
is: C00214

http://identifiers.org/biomodels.db/MODEL1310110054#_f13dd79f_6315_4926_a218_038f0d74e1be
is encoded by: hsa:4952
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q01968
name: OCRL

metaR r0475
is: SBO:0000176
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110054#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110054#
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_eb5c113a_eb10_4f9c_a86e_6234b93b9ebf
is: Q9H2X9
initial concentration: NaN
is encoded by: hsa:57468
boundary condition: true
constant: false
type: Species
has only substance units: false
name: SLC12A5
initial amount: NaN
is: SBO:0000252

metaM prostgd2 r
initial concentration: 1.0
boundary condition: false
is: HMDB01403
is: CHEBI:57406
is: SBO:0000247
type: Species
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
name: prostaglandin D2(1-)

http://identifiers.org/biomodels.db/MODEL1310110054#_ce56a7ad_500b_4e4a_baf9_c499e8440984
is: SBO:0000252
initial amount: NaN
name: HAS1
type: Species
is: Q8IYH3
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3036

http://identifiers.org/biomodels.db/MODEL1310110054#_4d919644_777b_472f_9dab_ac34be0a815a
initial concentration: NaN
constant: false
is: P14060
initial amount: NaN
is encoded by: hsa:3283
is: SBO:0000252
type: Species
name: HSD3B1
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_295a89d5_f548_46fd_9506_9229ced84000
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4830
has only substance units: false
name: NME1
initial amount: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_c
is: CHEBI:18287
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
constant: false
initial amount: NaN
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00174
type: Species
has only substance units: false

metaR r0752
modifier: MODEL1310110054#
product: MODEL1310110054#
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:

metaR r0580
modifier: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
type: Reaction
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.7
is: SBO:0000176
product: MODEL1310110054#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_fc1ec349_2954_403a_b178_d3912855a523
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P19404
initial amount: NaN
name: NDUFV2
is encoded by: hsa:4729
constant: false
type: Species
initial concentration: NaN

metaM 2hexdtetcoa m
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB02288
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial amount: NaN
name: 2,7,10,13-hexadecatetraenoylcoa
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_b71a1649_0f18_473a_9d60_50a83c91892f
is encoded by: hsa:27010
initial concentration: NaN
name: TPK1
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: F5GZG6

http://identifiers.org/biomodels.db/MODEL1310110054#_1a655365_affd_4127_b14b_df7cfbf8b67f
has only substance units: false
type: Species
is: E7ETH5
name: SLC13A2
is encoded by: hsa:9058
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_80905429_96f3_4c8e_9568_096121fd1f73
has only substance units: false
name: _AI684467_1_m
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:AI684467
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_bba05e87_87fa_42ea_9a73_70cd246cd8b3
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: SLC7A11:SLC3A2
is: SBO:0000297
boundary condition: true
initial concentration: NaN
is encoded by: hsa:23657
has part: Q9UPY5

http://identifiers.org/biomodels.db/MODEL1310110054#_cca31a38_1995_44e3_8a3a_39b457bb4825
constant: false
boundary condition: true
is: Q9NVE7
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
name: PANK4
initial concentration: NaN
is encoded by: hsa:55229

http://identifiers.org/biomodels.db/MODEL1310110054#_351ff7e1_1cc1_4891_8a87_65018c1d2ad0
name: DGKB
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:1607

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

metaR MM8Ber
is described by: ECO:0000000
fast: false
type: Reaction
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, endoplasmic reticulum
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.113
modifier: MODEL1310110054#
reversible: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (11253.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10409699,PMID:9592125 NOTES:NCD

metaM prist x
is: CHEBI:51340
name: pristanic acid
constant: false
is: HMDB00795
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
initial concentration: 1.0

metaR DESAT22 1p
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110054#
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
product: MODEL1310110054#
reactant: MODEL1310110054#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:

metaM HC01434 c
boundary condition: false
initial amount: NaN
name: oxalatosuccinate(3-)
initial concentration: 1.0
type: Species
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:58931

metaM pyr e
has only substance units: false
is: CHEBI:15361
initial amount: NaN
name: pyruvate
type: Species
boundary condition: false
is: HMDB00243
initial concentration: 1.0
constant: false
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: SBO:0000247

metaM 3sala c
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: C00606
has only substance units: false
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
initial amount: NaN
name: 3-Sulfino-L-alanine
constant: false
is: CHEBI:61085

metaR r1809
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport

metaR r0474
fast: false
reactant: MODEL1310110054#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
product: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110054#_8b6e7eed_c7dd_443c_8ce4_e0e8c2ed51fb
constant: false
boundary condition: true
is encoded by: hsa:AI769281
initial amount: NaN
name: _AI769281_1_e
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_db020ce9_806f_44d9_8faa_f9fb43ce8d0b
initial concentration: NaN
name: BLVRA
type: Species
is encoded by: hsa:644
has only substance units: false
initial amount: NaN
is: P53004
boundary condition: true
is: SBO:0000252
constant: false

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_fc87ab84_cb47_4b3d_a1ef_7bc4defcd2b5
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: HAO2
constant: false
is: SBO:0000252
is encoded by: hsa:51179

http://identifiers.org/biomodels.db/MODEL1310110054#_3fe53527_cb12_4b27_8d50_a804d35ec269
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:1716
has only substance units: false
boundary condition: true
initial concentration: NaN
name: DGUOK
initial amount: NaN

metaM lys L e
type: Species
is: HMDB00182
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:32551
name: L-lysinium(1+)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial amount: NaN

metaM man c
name: D-Mannose
boundary condition: false
is: SBO:0000247
is: C00159
constant: false
type: Species
is: HMDB00169
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16024
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_20532aa1_7517_4078_a95f_a457eaa465da
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q6PXP3
boundary condition: true
is encoded by: hsa:155184
constant: false
name: SLC2A7
initial concentration: NaN

metaM HC02180 e
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:28728
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
name: thromboxane-b2

metaR DOLDPP Uer
reversible: false
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
name: Dolichyl-diphosphate phosphohydrolase, human (uterus)
type: Reaction
is: SBO:0000176
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.6.1.43
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
is described by: ECO:0000000
fast: false
modifier: MODEL1310110054#

metaR r0754
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000000
modifier: MODEL1310110054#
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_d476ac19_d5a3_4604_81eb_72a1bc3beb3e
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5198
initial amount: NaN
is: Q6P4B4
name: PFAS
boundary condition: true
has only substance units: false
constant: false

metaR PPAn
fast: false
kinetic law: MODEL1310110054#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110054#
reactant: MODEL1310110054#
name: inorganic diphosphatase, nuclear
is described by: ECO:0000000
is: SBO:0000176

metaR DRIBt
product: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
name: deoxyribose transport via diffusion
fast: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
kinetic law: MODEL1310110054#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110054#_01eb1315_2639_4038_9d83_5e597b1b1f5c
constant: false
is: SBO:0000297
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:515
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has only substance units: false

metaM pan4p m
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial concentration: 1.0
boundary condition: false
name: pantetheine 4'-phosphate(2-)
is: CHEBI:47942
initial amount: NaN
is: SBO:0000247
is: HMDB01416
has only substance units: false
constant: false
type: Species

metaM ksi deg5 l
type: Species
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
is: HMDB00143
name: keratan sulfate I, degradation product 5
initial amount: NaN
constant: false
is: CHEBI:12936
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR DOCO13EFATP
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: absorption or uptake of 13-docosenoic acid into cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_44e0a334_198f_4166_b1df_39754aa4386d
initial concentration: NaN
is encoded by: hsa:2679
initial amount: NaN
is: SBO:0000252
name: GGT3P
boundary condition: true
constant: false
type: Species
has only substance units: false

metaM cs e deg1 l
is: HMDB00868
is: CHEBI:57737
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
constant: false
boundary condition: false
type: Species
initial amount: NaN

metaR r0753
reversible: true
fast: false
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
type: Reaction
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
is: SBO:0000176
modifier: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_966dffe3_d18f_44ff_92e1_af6ac4947a80
boundary condition: true
constant: false
is: P49902
initial amount: NaN
is encoded by: hsa:22978
name: NT5C2
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species

metaR PPAm
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
kinetic law: MODEL1310110054#
is: SBO:0000176
reversible: false
product: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
name: inorganic diphosphatase
is version of: http://identifiers.org/ec-code/3.6.1.1
modifier: MODEL1310110054#
is described by: ECO:0000269
fast: false

metaR r0472
fast: false
is: SBO:0000176
product: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

metaM dcmp c
initial concentration: 1.0
type: Species
is: HMDB01202
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
name: dCMP
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57566
boundary condition: false
is: C00239

http://identifiers.org/biomodels.db/MODEL1310110054#_0c0c3f4b_648a_472a_bf48_a17ecabd8626
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3290
name: HSD11B1
initial concentration: NaN
is: P28845
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_20f81902_3160_497a_9210_d530c28fbc41
has only substance units: false
boundary condition: true
is: Q9P0J0
constant: false
initial concentration: NaN
is encoded by: hsa:51079
type: Species
name: NDUFA13
is: SBO:0000252
initial amount: NaN

metaR ACONT
is: SBO:0000176
kinetic law: MODEL1310110054#
name: aconitase
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: (3658.1) or (48.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:SMP. Biochemical
reactant: MODEL1310110054#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.3
fast: false
modifier: MODEL1310110054#
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_fd910dda_cece_4a11_8081_8e52bb774bfb
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:5152
boundary condition: true
name: PDE9A
initial concentration: NaN
type: Species
is: SBO:0000252

metaM HC02180 c
name: thromboxane-b2
is: CHEBI:28728
is: SBO:0000247
constant: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false

metaM L2aadp m
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00510
name: L-2-aminoadipate(1-)
constant: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: CHEBI:58672
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_62f49d6a_6e85_4dd3_9e4b_43971d568aa8
is: SBO:0000252
type: Species
name: COX7B2
initial amount: NaN
has only substance units: false
is encoded by: hsa:170712
is: Q8TF08
constant: false
boundary condition: true
initial concentration: NaN

metaR GLCNACASE2ly
fast: false
kinetic law: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.50
is described by: ECO:0000000
reactant: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000176
name: alpha-N-acetylglucosaminidase, lysosomal
reversible: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_8c080e44_36f0_4a45_a076_476525778f74
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AU149534
type: Species
name: _AU149534_1_c
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00174
is: CHEBI:18287
has only substance units: false
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
type: Species
is: SBO:0000247

metaM ocdcea r
name: octadecenoate (n-C18:1)
constant: false
is: C00712
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1
is: HMDB00207
has only substance units: false
is: CHEBI:0

http://identifiers.org/biomodels.db/MODEL1310110054#_5059ac32_44f2_4f38_bcca_a0ef7fe71e3b
initial concentration: NaN
type: Species
name: CPT1C
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is: Q8TCG5
is encoded by: hsa:126129

metaR EX 3ddcrn
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

metaR RE1573M
is described by: ECO:0000000
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
name: RE1573
fast: false
modifier: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.3.8
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110054#

metaR DOLPMT4 Uer
fast: false
reversible: false
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110054#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110054#
type: Reaction

metaR TDCHOLAte
reversible: true
type: Reaction
reactant: MODEL1310110054#
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
is described by: ECO:0000000
name: bile acid intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110054#_56144066_6a6b_40f8_9155_278bd41fcd4e
is: A8K5Z0
has only substance units: false
is encoded by: hsa:8703
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
name: B4GALT3
initial amount: NaN
constant: false

metaR DOLPMT1 Ler
reactant: MODEL1310110054#
reversible: false
fast: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.258
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)

metaR RE1530C
product: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
reversible: true
is: SBO:0000176
name: RE1530
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
fast: false

metaR GLYPHEPEPT1tc
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycylphenylalanine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaM 4mptnl e
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
is: HMDB01318
boundary condition: false
is: CHEBI:17998
initial concentration: 1.0
constant: false
name: 4-methylpentanal
type: Species
is: SBO:0000247

metaR r0750
product: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
type: Reaction
reactant: MODEL1310110054#
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
is described by: ECO:0000000
modifier: MODEL1310110054#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110054#

metaM CE5114 x
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,20-21,28-30,34-36,40,51-52H,4-7,10,13,16-19,22-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,21-20+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE5114
constant: false
has only substance units: false
name: trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA
is: CHEBI:57923

http://identifiers.org/biomodels.db/MODEL1310110054#_0389bb11_7f45_455b_b2fb_32539e19371f
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: O95954
type: Species
name: FTCD
is encoded by: hsa:10841

http://identifiers.org/biomodels.db/MODEL1310110054#_c84722c1_133f_4e1d_ac11_53d62614dbb8
initial amount: NaN
is: Q9HBH5
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:57665
is: SBO:0000252
name: RDH14

metaR AG13T18g
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
modifier: MODEL1310110054#
fast: false
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.1.149

http://identifiers.org/biomodels.db/MODEL1310110054#_5aa95b99_d100_4d5d_91c6_811d0c5d8543
is encoded by: hsa:23657
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: SLC7A11
has only substance units: false
is: Q9UPY5
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_34675c33_ae1f_4fd9_91ec_e57c29ead1a5
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
name: _AA021081_1_r
initial concentration: NaN
is encoded by: hsa:AA021081

http://identifiers.org/biomodels.db/MODEL1310110054#_9e5943af_a014_4297_abf8_73f2002fc5f1
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:11001
name: SLC27A2
is: O14975
initial concentration: NaN

metaR 2AMADPTm
kinetic law: MODEL1310110054#
type: Reaction
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
modifier: MODEL1310110054#
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877

metaM Sfglutth c
constant: false
boundary condition: false
is: HMDB01550
name: S-formylglutathionate(1-)
is: SBO:0000247
is: CHEBI:57688
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR r1400
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110054#
is described by: ECO:0000000
product: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
name: Active transport
fast: false

metaR DURIt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
product: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000
name: deoxyuridine transport via diffusion
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_a1cadcb0_c6b9_4fe9_b20a_4513393845d7
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:1635
initial amount: NaN
name: DCTD
is: SBO:0000252
type: Species
is: P32321
initial concentration: NaN

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

metaR r0310
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
product: MODEL1310110054#
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
fast: false
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#

metaM CE1617 r
is: CHEBI:17898
constant: false
name: 9-cis-retinoate
boundary condition: false
is: HMDB01358
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8-,16-14+ EHMN_ABBREVIATION: CE1617
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_e
is: SBO:0000247
is: HMDB00660
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:15824
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
constant: false
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
type: Species
is: C00095

metaM pyr c
is: CHEBI:15361
is: C00022
name: pyruvate
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H3O3 CHARGE: -1
is: http://identifiers.org/pubchem.compound/3324
is: SBO:0000247
is: HMDB00243
type: Species
constant: false
has only substance units: false

metaR FAOXC8DCC6DCx
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8DC-->C6DC)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_fa19170f_759b_44c4_bf68_c126e24c3731
is encoded by: hsa:4594
type: Species
is: P22033
constant: false
initial amount: NaN
name: MUT
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR r1401
is version of: http://identifiers.org/ec-code/3.2.1.35
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.3.1.51
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.10.1
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.1.1.3
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.41
name: Facilitated diffusion
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
type: Reaction
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110054#_7f090ae9_9a72_4cc1_9de4_79aaf1699379
is: A8MYF6
has only substance units: false
is: SBO:0000252
type: Species
name: MSMO1
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6307
constant: false

metaM HC02202 c
type: Species
initial concentration: 1.0
name: prostaglandin A1(1-)
initial amount: NaN
is: CHEBI:57398
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
boundary condition: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_4592835f_cd14_43f6_a354_6a81f48a625d
name: BCKDHA
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:593
constant: false
boundary condition: true
is: B4DP47
initial amount: NaN
initial concentration: NaN

metaR HOMt4
reactant: MODEL1310110054#
fast: false
product: MODEL1310110054#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (6541.1) or (84889.1) or (6542.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
kinetic law: MODEL1310110054#
is described by: ECO:0000269
is: SBO:0000185
name: L-homoserine via sodium symport
modifier: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_80f008c9_3bbc_4d87_9fcf_e48048ca7b90
has only substance units: false
name: SLC23A1
initial amount: NaN
boundary condition: true
is encoded by: hsa:9963
type: Species
is: SBO:0000252
constant: false
is: Q9UHI7
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_d0cd687a_06b7_4553_95f0_b301ed31edb2
is encoded by: hsa:518
name: ATP5G3
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
is: SBO:0000252

metaM mlthf m
is: C00143
is: CHEBI:15636
constant: false
name: 5,10-Methylenetetrahydrofolate
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: HMDB01533
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR r1116
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
is: SBO:0000185
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction

metaM doco13ac e
is: SBO:0000247
type: Species
is: HMDB02068
initial amount: NaN
constant: false
notes: FORMULA: C22H41O2 CHARGE: -1
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: docosenoic acid (C22:1)

metaM adp c
initial concentration: 1.0
is: HMDB01341
type: Species
has only substance units: false
is: C00008
is: SBO:0000247
boundary condition: false
is: CHEBI:16761
name: ADP
is: http://identifiers.org/pubchem.compound/3310
constant: false
initial amount: NaN

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_4da1ac66_fd54_4a4c_9f88_dcd7c948ed33
is: Q96C36
is: SBO:0000252
type: Species
boundary condition: true
name: PYCR2
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:29920
initial concentration: NaN

metaM CE0849 m
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:57795
name: cis,cis-palmito-7,10-dienoyl-CoA
boundary condition: false
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849

metaR r0311
modifier: MODEL1310110054#
is: SBO:0000176
type: Reaction
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
reversible: false
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.9

metaR PUNP4
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.2.1
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
modifier: MODEL1310110054#
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Deoxyguanosine)
reversible: true
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110054#

metaR r1857
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110054#
product: MODEL1310110054#
fast: false
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110054#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110054#

metaM CE2421 m
name: (3S)-3-hydroxylinoleoyl-CoA
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB02329
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
is: CHEBI:30623

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaR ADSL2
reactant: MODEL1310110054#
name: adenylosuccinate lyase
modifier: MODEL1310110054#
is described by: ECO:0000269
product: MODEL1310110054#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.3.2.2
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_4e218379_2a03_4f98_b9e6_380239fc4e2b
name: ALDH4A1
initial concentration: NaN
is encoded by: hsa:8659
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false

metaR r1812
reversible: false
is: SBO:0000185
type: Reaction
modifier: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM pail4p hs c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
is: CHEBI:58178

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_f5b47d42_1c4f_4792_b919_e26aa1c65cad
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5152
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: PDE9A
constant: false

metaR PUNP5
kinetic law: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is: SBO:0000176
reversible: true
product: MODEL1310110054#
name: purine-nucleoside phosphorylase (Inosine)
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110054#_0e6408b4_e2ad_4323_83a7_4fff6cbcf5ac
is encoded by: hsa:AA532636
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
name: _AA532636_1_m
type: Species

metaR RAI1
is described by: ECO:0000000
kinetic law: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: retinal isomerase (11-cis)
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110054#
type: Reaction

metaM g1m8masn r
is: SBO:0000247
boundary condition: false
is: C05875
type: Species
notes: FORMULA: C76H127N2O60X CHARGE: 0
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

metaR ACP1 FMN
product: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.2
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000254
reversible: false
is: SBO:0000176
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:8522318 NOTES:INVALID ECO TERM: IFH
type: Reaction
name: acid phosphatase (FMN)

metaR GBA
type: Reaction
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.45
is: SBO:0000176
modifier: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000000
name: Glucosylceramidase
reactant: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_4a3054bf_c735_4815_9add_c8871e320f4b
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: P51648
is encoded by: hsa:224
name: ALDH3A2
boundary condition: true

metaM L2aadp c
is: CHEBI:58672
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00510
name: L-2-aminoadipate(1-)

http://identifiers.org/biomodels.db/MODEL1310110054#_c408b613_4e19_4998_8a46_19bdcdbe5ce9
is: F8VQS7
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:55967
constant: false
initial concentration: NaN
has only substance units: false
name: NDUFA12

metaR URCN
modifier: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
name: URCN
is: SBO:0000176
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110054#
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.49
product: MODEL1310110054#
is described by: ECO:0000269
fast: false

metaR S6T16g
is described by: ECO:0000000
product: MODEL1310110054#
is: SBO:0000176
reactant: MODEL1310110054#
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
type: Reaction
reversible: false

metaR FAOXC140
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110054#
reactant: MODEL1310110054#
name: Beta oxidation of long chain fatty acid
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110054#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_54b0b2ae_a9ed_48f4_99ad_b6f217c8ae21
is: P78329
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
name: CYP4F2
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8529

http://identifiers.org/biomodels.db/MODEL1310110054#_959c06f7_550f_40a2_a933_7dc7812fc5bc
is: SBO:0000252
name: UROC1
has only substance units: false
is: Q68CJ7
boundary condition: true
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:131669

http://identifiers.org/biomodels.db/MODEL1310110054#_a0f106f2_9857_48f4_a34d_c3e7e8dded45
constant: false
initial concentration: NaN
is: F8WDN9
name: PPA2
initial amount: NaN
is encoded by: hsa:27068
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false

metaR r2036
is described by: ECO:0000000
product: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
modifier: MODEL1310110054#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110054#_5a28920d_486d_46f7_a61b_ba3a1a33106c
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:7390
is: P10746
has only substance units: false
boundary condition: true
initial concentration: NaN
name: UROS

metaR PUNP2
is version of: http://identifiers.org/ec-code/2.4.2.1
is described by: ECO:0000269
fast: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
name: purine-nucleoside phosphorylase (Deoxyadenosine)
product: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#
reversible: true
type: Reaction

metaR r1964
kinetic law: MODEL1310110054#
reversible: false
fast: false
type: Reaction
product: MODEL1310110054#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reactant: MODEL1310110054#
modifier: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_5562a861_421f_4584_b15a_89b975af81a6
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
boundary condition: true
initial concentration: NaN
name: ADSL
is: P30566
is encoded by: hsa:158
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_acb2d4e0_e29f_4bf8_9766_ea936c443d66
has part: P03897
is encoded by: hsa:4706
is encoded by: hsa:4696
boundary condition: true
has part: Q7GXZ1
has part: H7C5B8
has part: O95169
has part: Q16795
is encoded by: hsa:4716
has part: O43678
has part: Q7GXZ4
is encoded by: hsa:4541
is encoded by: hsa:374291
has part: Q9P0J0
has part: E5KNH5
is encoded by: hsa:4729
is encoded by: hsa:4695
is encoded by: hsa:4722
is encoded by: hsa:7991
is encoded by: hsa:4698
is encoded by: hsa:4713
is encoded by: hsa:4536
has part: Q85KV6
has part: B7Z792
is encoded by: hsa:4731
is encoded by: hsa:4712
is encoded by: hsa:4705
has part: P03905
has part: P56556
has part: P56181
has part: P19404
has part: Q9Y6M9
has part: O95167
has part: Q6IBB5
is: SBO:0000297
is encoded by: hsa:4715
has part: A8K761
has part: O95139
is encoded by: hsa:4718
is encoded by: hsa:4694
has part: P28331
is encoded by: hsa:4709
has part: P17568
has part: O00483
is encoded by: hsa:4710
is encoded by: hsa:4701
is encoded by: hsa:4702
is encoded by: hsa:4540
is encoded by: hsa:4535
has only substance units: false
has part: B1AM93
is encoded by: hsa:4539
has part: O14561
has part: O00217
is encoded by: hsa:4728
is encoded by: hsa:4719
has part: Q6IB80
has part: Q549M5
is encoded by: hsa:4720
is encoded by: hsa:55967
is encoded by: hsa:4725
is encoded by: hsa:4711
is encoded by: hsa:4726
constant: false
is encoded by: hsa:4538
has part: O43181
has part: P03915
has part: C9JT23
has part: O43674
is encoded by: hsa:4704
has part: Q6IBA0
has part: F8VQS7
has part: O95168
has part: O43677
is encoded by: hsa:4697
is encoded by: hsa:4717
has part: Q13454
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
initial amount: NaN
has part: O75251

metaM ca2 e
is: SBO:0000247
has only substance units: false
name: calcium(2+)
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: HMDB00464
initial amount: NaN
initial concentration: 1.0
is: CHEBI:29108
type: Species
constant: false
boundary condition: false

metaR PUNP3
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false
name: purine-nucleoside phosphorylase (Guanosine)
modifier: MODEL1310110054#
reactant: MODEL1310110054#
reversible: true
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000176

metaM tre e
type: Species
initial amount: NaN
is: C01083
is: SBO:0000247
is: CHEBI:16551
constant: false
has only substance units: false
is: HMDB00975
name: Trehalose
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
initial concentration: 1.0
boundary condition: false

metaM gm3 hs g
constant: false
type: Species
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
initial concentration: 1.0
boundary condition: false
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
has only substance units: false
initial amount: NaN
is: CHEBI:60065
is: SBO:0000247

metaR FUT910g
kinetic law: MODEL1310110054#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.152
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
modifier: MODEL1310110054#
name: Alpha-(1,3)-fucosyltransferase
product: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110054#_2686f04f_b34b_46ef_a364_e119f56dc11e
is: SBO:0000252
name: LYZL1
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:84569
is: Q6UWQ5
constant: false
initial concentration: NaN

metaR NAGLCAly
kinetic law: MODEL1310110054#
is: SBO:0000176
is described by: ECO:0000000
name: N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
fast: false
type: Reaction
product: MODEL1310110054#
reactant: MODEL1310110054#
reversible: false

metaR DADNt4
reactant: MODEL1310110054#
name: deoxyadenosine transport via diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
fast: false
product: MODEL1310110054#
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110054#

metaR THRASNNaEx
reversible: false
product: MODEL1310110054#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
modifier: MODEL1310110054#
name: L-threonine/L-asparagine Na-dependent exchange (Thr-L in)
kinetic law: MODEL1310110054#
is described by: ECO:0000269
reactant: MODEL1310110054#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_00f43c94_5bab_4b9f_bccb_64be40036372
constant: false
type: Species
is: E5KNH5
initial amount: NaN
boundary condition: true
is encoded by: hsa:4723
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: NDUFV1

metaR RE2660N
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.96
reversible: true
reactant: MODEL1310110054#
product: MODEL1310110054#
name: RE2660
is: SBO:0000176
type: Reaction

metaM methf m
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: SBO:0000247
has only substance units: false
is: CHEBI:57455
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: HMDB01354
initial amount: NaN
name: (6R)-5,10-methenyltetrahydrofolate

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_90922393_470c_47e6_8266_3477e7ea33b6
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: GLRX2
is encoded by: hsa:51022

metaM mlthf c
name: 5,10-Methylenetetrahydrofolate
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:15636
initial concentration: 1.0
is: SBO:0000247
is: HMDB01533
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: C00143
has only substance units: false

metaM lnlccrn c
is: HMDB06469
type: Species
name: Linoleyl carnitine
constant: false
boundary condition: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaM ksii core4 pre10 g
is: SBO:0000247
is: CHEBI:28067
constant: false
has only substance units: false
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: keratan sulfate II biosynthesis, precursor 10

metaR PETHCT
kinetic law: MODEL1310110054#
is described by: ECO:0000269
modifier: MODEL1310110054#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.14
name: phosphoethanolamine cytidyltransferase
reversible: false
fast: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (5833.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.14 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_2f5f870f_ae53_40c8_9755_329fa5280302
initial amount: NaN
constant: false
boundary condition: true
type: Species
is: C9JPQ8
is encoded by: hsa:5095
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: PCCA

http://identifiers.org/biomodels.db/MODEL1310110054#_805eb58f_e554_4b43_bd5a_644cc91f9be7
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
name: ATP5A1
is: B4DY56
has only substance units: false
is encoded by: hsa:498
type: Species

metaM ca2 c
initial concentration: 1.0
is: CHEBI:29108
is: HMDB00464
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: calcium(2+)

metaM eicostet e
type: Species
boundary condition: false
has only substance units: false
constant: false
name: eicosatetranoic acid
is: CHEBI:36033
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H31O2 CHARGE: -1
is: HMDB02177
initial amount: NaN

metaR r0317
product: MODEL1310110054#
modifier: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
reactant: MODEL1310110054#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.1.2.10
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.8.1.4
is: SBO:0000176
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.4.4.2

metaM damp c
initial amount: NaN
is: HMDB00905
type: Species
initial concentration: 1.0
is: SBO:0000247
name: dAMP(2-)
is: CHEBI:58245
has only substance units: false
boundary condition: false
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
constant: false

metaR CDIPTr
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
is version of: http://identifiers.org/ec-code/2.7.8.11
is described by: ECO:0000000
name: phosphatidylinositol synthase (Homo sapiens)
is: SBO:0000176
product: MODEL1310110054#
type: Reaction
fast: false
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
reversible: true
modifier: MODEL1310110054#

metaR PPItx
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
name: Diphosphate transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110054#
is described by: ECO:0000000
type: Reaction

metaM tetde5coa x
is: SBO:0000247
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
is: HMDB11123
is: C05279
type: Species
name: 5-tetradecenoylcoa
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false

metaR PUNP6
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.2.1
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
name: purine-nucleoside phosphorylase (Deoxyinosine)
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110054#
type: Reaction

metaR RE0830N
product: MODEL1310110054#
reversible: true
reactant: MODEL1310110054#
modifier: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/4.2.1.96
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
type: Reaction
name: RE0830

metaR FAOXC1811603m
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110054#
is described by: ECO:0000269
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000176
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation fatty acid

metaR FATP9t
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
modifier: MODEL1310110054#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/6.2.1.7
is described by: ECO:0000269
name: fatty acid electroneutral transport

http://identifiers.org/biomodels.db/MODEL1310110054#_90d8c2b3_f2d8_4bab_9b47_d588640c10be
type: Species
boundary condition: true
constant: false
name: _AA419122_1_c
is encoded by: hsa:AA419122
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM CE2838 e
is: SBO:0000247
name: maltononaose
is: http://identifiers.org/pubchem.compound/5041
is: C01936
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838

http://identifiers.org/biomodels.db/MODEL1310110054#_46e29527_ebc3_4529_84b1_d609bab4ae23
type: Species
is encoded by: hsa:100
constant: false
initial concentration: NaN
name: ADA
initial amount: NaN
is: P00813
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_eb41dce4_c660_4f84_88b8_849029c655e6
is encoded by: hsa:5313
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: PKLR
boundary condition: true
is: P30613

metaR DURItn
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
kinetic law: MODEL1310110054#
type: Reaction
name: deoxyuridine transport in nucleus
reactant: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000000
reversible: true

metaR RE3566C
is: SBO:0000176
reactant: MODEL1310110054#
is described by: ECO:0000000
product: MODEL1310110054#
fast: false
type: Reaction
kinetic law: MODEL1310110054#
reversible: true
name: RE3566
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:

metaR 34DHXMANDACOX
fast: false
is described by: ECO:0000269
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reversible: false
type: Reaction
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR DTTPtn
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110054#
name: dTTP diffusion in nucleus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
fast: false
kinetic law: MODEL1310110054#
is: SBO:0000185
product: MODEL1310110054#

metaR PUNP7
type: Reaction
kinetic law: MODEL1310110054#
is described by: ECO:0000269
modifier: MODEL1310110054#
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
fast: false
name: purine-nucleoside phosphorylase (Xanthosine)
is: SBO:0000176

metaM HC01223 m
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:57340
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
type: Species
boundary condition: false
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
constant: false
is: SBO:0000247

metaR GGH 10FTHF6GLUe
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
type: Reaction
fast: false
product: MODEL1310110054#
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
reactant: MODEL1310110054#

metaM 5forthf c
type: Species
initial amount: NaN
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
has only substance units: false
is: SBO:0000247
constant: false
is: C00664
is: HMDB01534
is: CHEBI:57456
name: 5-Formiminotetrahydrofolate
initial concentration: 1.0
boundary condition: false

metaR r1552
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
product: MODEL1310110054#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction

metaR r2373
is: SBO:0000185
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110054#
reversible: true
product: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaM phyt c
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
is: SBO:0000247
name: phytanate
is: CHEBI:37257
type: Species
boundary condition: false
has only substance units: false
constant: false
is: HMDB00801
initial concentration: 1.0
initial amount: NaN

metaM 34hpp e
constant: false
is: HMDB00707
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:36242
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: 3-(4-hydroxyphenyl)pyruvate

metaR RPEc
is: SBO:0000176
kinetic law: MODEL1310110054#
reversible: true
product: MODEL1310110054#
fast: false
type: Reaction
name: ribulose 5-phosphate 3-epimerase
is described by: ECO:0000134
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2

metaR FAS160COA
product: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000176
name: fatty-acyl-CoA synthase (n-C16:0CoA)
fast: false
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
type: Reaction
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR NACHEX13ly
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
modifier: MODEL1310110054#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110054#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110054#
is: SBO:0000176
fast: false

metaR PPItr
name: Diphosphate transporter, endoplasmic reticulum
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110054#
reactant: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#

metaR FUT15g
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
type: Reaction
reactant: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.69
is described by: ECO:0000269
product: MODEL1310110054#
is: SBO:0000176
modifier: MODEL1310110054#
name: Galactoside 2-alpha-L-fucosyltransferase 1

http://identifiers.org/biomodels.db/MODEL1310110054#_4f8af3d0_edbd_4730_b74b_54c372bdcf3b
is: SBO:0000252
is: O95622
has only substance units: false
type: Species
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:111
name: ADCY5

metaM eicostet c
name: eicosatetranoic acid
type: Species
initial concentration: 1.0
notes: FORMULA: C20H31O2 CHARGE: -1
is: CHEBI:36033
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: HMDB02177

metaM 35cgmp n
is: HMDB01314
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: 3',5'-cyclic GMP(1-)
has only substance units: false
is: CHEBI:57746

http://identifiers.org/biomodels.db/MODEL1310110054#_06efc7b3_2a34_4b83_b4f1_8a5f32631744
is encoded by: hsa:2629
has only substance units: false
is: P04062
is: SBO:0000252
name: GBA
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
constant: false

metaM arab L e
initial amount: NaN
is: CHEBI:30849
notes: FORMULA: C5H10O5 CHARGE: 0
name: L-arabinose
boundary condition: false
has only substance units: false
constant: false
type: Species
is: HMDB00646
is: SBO:0000247
initial concentration: 1.0

metaR r1551
reactant: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
product: MODEL1310110054#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185

metaR r1969
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110054#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
product: MODEL1310110054#
type: Reaction
name: Y+LAT2 Utilized transport

metaM succ x
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
initial concentration: 1.0
name: Succinate
is: C00042
is: CHEBI:30031
has only substance units: false
constant: false
is: HMDB00254
boundary condition: false

metaM HC02210 e
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
has only substance units: false
name: prostaglandin-d3
boundary condition: false
initial concentration: 1.0
is: CHEBI:34939
type: Species
initial amount: NaN
constant: false
is: SBO:0000247

metaR r2374
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
kinetic law: MODEL1310110054#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110054#

metaR URIDK2m
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
is described by: ECO:0000134
is: SBO:0000176
reversible: true
product: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
name: uridylate kinase (dUMP), mitochondrial
fast: false

metaM phyt e
is: SBO:0000247
name: phytanate
type: Species
is: HMDB00801
constant: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
has only substance units: false
initial concentration: 1.0
is: CHEBI:37257
boundary condition: false
initial amount: NaN

metaM lys L x
is: CHEBI:32551
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
has only substance units: false
initial concentration: 1.0
type: Species
name: L-lysinium(1+)
constant: false
is: HMDB00182

http://identifiers.org/biomodels.db/MODEL1310110054#_b7128973_24e5_400b_9d84_1a9e1c753468
is: SBO:0000252
has only substance units: false
name: PDE6D
is encoded by: hsa:5147
boundary condition: true
is: O43924
type: Species
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_844bc809_e382_4931_beef_e3d5e7afc613
is encoded by: hsa:5728
type: Species
has only substance units: false
initial amount: NaN
is: F6KD01
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: PTEN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_997e2710_b3c8_49f5_8256_c823599d5472
has only substance units: false
name: NDUFA4L2
type: Species
is encoded by: hsa:56901
is: SBO:0000252
is: Q9NRX3
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM phaccoa c
is: CHEBI:57390
is: HMDB06503
constant: false
has only substance units: false
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
name: phenylacetyl-CoA(4-)
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false

metaR CYTK11n
reactant: MODEL1310110054#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reversible: true
modifier: MODEL1310110054#
product: MODEL1310110054#
name: cytidylate kinase (dCMP,dGTP),nuclear
type: Reaction
fast: false
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110054#_6629ff36_0143_4a44_bd93_20532e74689c
type: Species
boundary condition: true
is encoded by: hsa:4704
is: Q16795
name: NDUFA9
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false

metaR r2371
is: SBO:0000185
kinetic law: MODEL1310110054#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reversible: true
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110054#
is described by: ECO:0000000
type: Reaction

metaM cmpacna c
is: HMDB01176
name: CMP-N-acetyl-beta-neuraminate(2-)
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial amount: NaN
is: CHEBI:57812
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false

metaR GLYCTO1p
kinetic law: MODEL1310110054#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110054#
type: Reaction
reversible: false
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.1.3.15
is: SBO:0000176
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
name: Glycolate oxidase, peroxisome
product: MODEL1310110054#

metaM adp m
initial concentration: 1.0
has only substance units: false
constant: false
name: ADP
is: http://identifiers.org/pubchem.compound/3310
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB01341
boundary condition: false
is: C00008
is: CHEBI:456216

metaR GCHOLAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
type: Reaction
name: bile acid intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110054#
is: SBO:0000185
fast: false
reactant: MODEL1310110054#
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_b2395858_8921_451f_bab0_3509c7f7ba38
is: O14986
constant: false
has only substance units: false
name: PIP5K1B
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:8395
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_4292db9e_336f_4d6c_9fea_7244e27374a8
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
name: PDE5A
constant: false
initial concentration: NaN
is encoded by: hsa:8654
is: SBO:0000252

metaM g1p c
is: HMDB01586
type: Species
is: C00103
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
name: D-Glucose 1-phosphate
is: CHEBI:58601
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false

metaR DATPtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID: 16816105, PMID: 17403938. NOTES:
is: SBO:0000185
is described by: ECO:0000134
name: transport of dATP into mitochondria
reversible: false
product: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
fast: false

metaM galgluside hs l
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
name: galactosyl glucosyl ceramide
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
is: CHEBI:12936
type: Species
is: HMDB00143

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaR NADH2 u10m
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.6.99.3
reactant: MODEL1310110054#
reversible: false
type: Reaction
fast: false
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.6.5.3
is described by: ECO:0000134
kinetic law: MODEL1310110054#
name: NADH dehydrogenase, mitochondrial

metaM 34hpp c
initial amount: NaN
is: CHEBI:36242
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
boundary condition: false
is: HMDB00707
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
name: 3-(4-hydroxyphenyl)pyruvate
type: Species

metaM methf c
constant: false
type: Species
is: CHEBI:57455
is: HMDB01354
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
has only substance units: false
initial amount: NaN
is: C00445
name: 5,10-Methenyltetrahydrofolate
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR UDPGALtg
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
product: MODEL1310110054#
modifier: MODEL1310110054#
reversible: true
reactant: MODEL1310110054#
is: SBO:0000185
type: Reaction
fast: false
name: UDP-Gal Golgi transport via CMP antiport
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_9a5477dd_4f17_465b_964c_83609e4d57b8
type: Species
is encoded by: hsa:280
initial concentration: NaN
name: AMY2B
has only substance units: false
is: P19961
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

metaR FAOXC163C164x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)x
type: Reaction

metaR r0166
product: MODEL1310110054#
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
kinetic law: MODEL1310110054#

metaM 3aib D m
initial amount: NaN
is: HMDB02299
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
name: D-3-Amino-isobutanoate
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: C03265

metaR r2372
fast: false
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110054#_97ad3d98_0d19_4534_872a_2c0daf9b616d
type: Species
name: _H77542_1_c
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:H77542
is: SBO:0000252
initial amount: NaN
constant: false

metaM HC02210 c
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: prostaglandin-d3
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
constant: false
has only substance units: false
is: CHEBI:34939
initial amount: NaN

metaR r0013
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.52 Confidence Level: 0 AUTHORS: PMID:10481922,PMID:2423070,PMID:6219664,PMID:758959 NOTES:
kinetic law: MODEL1310110054#
fast: false
modifier: MODEL1310110054#
type: Reaction
name: beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52
reversible: false
reactant: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110054#_5a4d162e_6bdf_4d4b_9a97_60c8d69b1b0b
boundary condition: true
is: P30048
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:10935
initial concentration: NaN
type: Species
has only substance units: false
name: PRDX3

http://identifiers.org/biomodels.db/MODEL1310110054#_442fc710_7d17_46ff_a007_6f4914a23db4
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: NOS1
is encoded by: hsa:4842
type: Species
is: B4DG68
is: SBO:0000252
has only substance units: false
constant: false

metaM ivcoa m
is: CHEBI:57345
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
initial concentration: 1.0
constant: false
name: Isovaleryl-CoA
is: HMDB01113

http://identifiers.org/biomodels.db/MODEL1310110054#_8ab2a396_181f_4179_b87f_2595a0dc0928
boundary condition: true
type: Species
initial amount: NaN
name: CYP8B1
is encoded by: hsa:1582
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q9UNU6
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_8db76302_b41a_4780_8943_b085d24481c3
name: COX6B1
initial concentration: NaN
is: P14854
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:1340
boundary condition: true

metaR HS3ly
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
reversible: false
is described by: ECO:0000000
product: MODEL1310110054#
fast: false
name: heparan-N-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.10.1.1
type: Reaction
is: SBO:0000176

metaR PPItm
product: MODEL1310110054#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
is: SBO:0000185
name: diphopshate transporter, mitochondrial
kinetic law: MODEL1310110054#
is described by: ECO:0000134
reactant: MODEL1310110054#

metaR r1556
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: true
fast: false

metaM lpam m
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
type: Species
is: CHEBI:17460
is: HMDB00962
constant: false
is: SBO:0000247
name: lipoamide
has only substance units: false

metaM HC01434 x
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:58931
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
name: oxalatosuccinate(3-)
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_e56705f9_25c1_4183_98b0_64ebdac01cb1
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:2982
is encoded by: hsa:2974
has part: D6RDW3
initial concentration: NaN
is: SBO:0000297
type: Species
boundary condition: true
name: GUCY1B2:GUCY1A3

metaR PUNP1
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reversible: true
name: purine-nucleoside phosphorylase (Adenosine)
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
modifier: MODEL1310110054#
is: SBO:0000176
is described by: ECO:0000269

metaM 3ddcrn c
notes: FORMULA: C19H37NO5 CHARGE: 0
initial amount: NaN
is: C14143
boundary condition: false
constant: false
has only substance units: false
name: 3-hydroxydodecanoylcarnitine
is: HMDB04047
type: Species
initial concentration: 1.0
is: SBO:0000247

metaM cgly e
has only substance units: false
is: CHEBI:4047
type: Species
initial amount: NaN
name: L-cysteinylglycine
constant: false
is: HMDB00078
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
boundary condition: false

metaM pan4p c
boundary condition: false
name: Pantetheine 4'-phosphate
initial concentration: 1.0
is: C01134
initial amount: NaN
constant: false
is: HMDB01416
has only substance units: false
is: CHEBI:47942
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: SBO:0000247
type: Species

metaM ahcys c
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: CHEBI:16680
type: Species
is: HMDB00939
boundary condition: false
has only substance units: false
initial amount: NaN
name: S-Adenosyl-L-homocysteine
is: SBO:0000247
initial concentration: 1.0
is: C00021
constant: false

metaR M14NTg
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.144
name: beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
fast: false
type: Reaction
product: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4248.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.144 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_5f2f6aad_d69d_4eab_88ab_49b2a168fc44
is encoded by: hsa:4830
constant: false
name: NME1:NME2
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000297
has only substance units: false

metaR LALDO2x
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF
fast: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000269
reactant: MODEL1310110054#
modifier: MODEL1310110054#
type: Reaction
name: D-Lactaldehyde:NAD+ 1-oxidoreductase

metaR PSERT
modifier: MODEL1310110054#
name: phosphoserine transaminase
fast: false
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.6.1.52
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#

metaR PDX5PO
is described by: ECO:0000269
kinetic law: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES:NCD
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.4.3.5
is: SBO:0000176
name: pyridoxine 5'-phosphate oxidase
modifier: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
reversible: true

metaR NTP3e
reactant: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176
modifier: MODEL1310110054#
name: nucleoside-triphosphatase (GTP)
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.6
fast: false
type: Reaction
kinetic law: MODEL1310110054#
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110054#_9740bd26_5826_4c99_a9d7_ca841b28ee1c
is: SBO:0000252
constant: false
is encoded by: hsa:53919
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: SLCO1C1
boundary condition: true
is: Q5JPA4

http://identifiers.org/biomodels.db/MODEL1310110054#_c15b1728_ff30_4a88_ab8f_b224c256fc31
is: Q7Z4W1
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:51181
type: Species
name: DCXR
boundary condition: true
has only substance units: false

metaR PPCOACm
type: Reaction
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000269
fast: false
is: SBO:0000176
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (5096.1 and 5095.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.3 Confidence Level: 4 AUTHORS: PMID:3460076,PMID:8188292 NOTES:TV
is version of: http://identifiers.org/ec-code/6.4.1.3
product: MODEL1310110054#
reversible: false
name: Propionyl-CoA carboxylase, mitochondrial

metaR r1855
kinetic law: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110054#
fast: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false

metaM ksii core2 deg1 l
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
is: HMDB00868
initial amount: NaN
is: CHEBI:57737
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 1
has only substance units: false

metaM Ssq23epx r
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:15441
type: Species
is: HMDB01188
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
constant: false
initial amount: NaN
name: (S)-2,3-epoxysqualene

http://identifiers.org/biomodels.db/MODEL1310110054#_27e0c4e9_6655_4c0c_81fd_54e5281a2e94
is: SBO:0000252
name: ATG9B
initial concentration: NaN
boundary condition: true
constant: false
is: Q674R7
is encoded by: hsa:285973
initial amount: NaN
has only substance units: false
type: Species

metaM cmpacna g
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB01176
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
has only substance units: false
name: CMP-N-acetyl-beta-neuraminate(2-)
type: Species
boundary condition: false
is: CHEBI:57812

http://identifiers.org/biomodels.db/MODEL1310110054#_5bc1b135_54de_406d_a189_eafd7f9e7681
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:51227
is: SBO:0000297
type: Species
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ

metaM 3sala m
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: C00606
boundary condition: false
has only substance units: false
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
initial amount: NaN
is: CHEBI:61085
name: 3-sulfino-L-alanine (1-)

http://identifiers.org/biomodels.db/MODEL1310110054#_e42babab_6d46_4839_b3eb_67068d42a870
initial amount: NaN
type: Species
name: ACPP
has only substance units: false
boundary condition: true
is encoded by: hsa:55
constant: false
is: P15309
is: SBO:0000252
initial concentration: NaN

metaR r1554
fast: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110054#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reversible: true
is: SBO:0000185

metaR VALTAm
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110054#
name: valine transaminase, mitochondiral
product: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_bf66c740_c7e7_4cde_88ee_88f7cc7e5e28
initial amount: NaN
is encoded by: hsa:1384
boundary condition: true
type: Species
initial concentration: NaN
constant: false
name: CRAT
has only substance units: false
is: SBO:0000252

metaM sphgn c
has only substance units: false
type: Species
initial concentration: 1.0
name: sphinganine(1+)
is: HMDB00269
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
constant: false
is: CHEBI:57817

metaM thmpp m
is: HMDB01372
name: Thiamine diphosphate
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 INCHI: InChI=1S/C12H18N4O7P2S/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21) HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
is: CHEBI:45931
constant: false
initial concentration: 1.0

metaR ADSL1
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/4.3.2.2
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
product: MODEL1310110054#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110054#
name: adenylosuccinate lyase

http://identifiers.org/biomodels.db/MODEL1310110054#_43976c59_f63f_4035_9c8a_6a5578ed2cc2
boundary condition: true
type: Species
is encoded by: hsa:8693
name: GALNT4
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q8N4A0

metaR RE2660C
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
name: RE2660
is: SBO:0000176
product: MODEL1310110054#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#

metaM 3ddcrn e
has only substance units: false
type: Species
is: SBO:0000247
name: 3-hydroxydodecanoylcarnitine
is: HMDB01088
notes: FORMULA: C19H37NO5 CHARGE: 0
is: C00136
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false

metaR GLYt7 211 r
reversible: true
fast: false
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110054#
product: MODEL1310110054#
modifier: MODEL1310110054#
name: glycine reversible transport via sodium and chloride symport (2:1:1)
reactant: MODEL1310110054#
is: SBO:0000185

metaM prist c
has only substance units: false
initial concentration: 1.0
name: pristanic acid
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:51340
is: HMDB00795
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
constant: false
boundary condition: false

metaM xoltriol m
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:16496
type: Species
is: HMDB01457
is: SBO:0000247
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
boundary condition: false

metaM cgly c
is: CHEBI:4047
type: Species
name: L-cysteinylglycine
initial amount: NaN
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00078
is: SBO:0000247
has only substance units: false

metaR r1553
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110054#
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110054#

metaR CYSTGLUex
is: SBO:0000185
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
name: L-cystine/L-glutamate exchanger
type: Reaction
modifier: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: (23657.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
product: MODEL1310110054#

metaM 2obut c
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
initial concentration: 1.0
boundary condition: false
is: CHEBI:16763
name: 2-Oxobutanoate
has only substance units: false
is: HMDB00005
constant: false
is: SBO:0000247
is: C00109
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_64b11449_0fe1_4424_9c2d_98a33c6dac92
is encoded by: hsa:2639
constant: false
initial concentration: NaN
has only substance units: false
name: GCDH
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM m8masn r
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: C05876
constant: false
notes: FORMULA: C70H117N2O55X CHARGE: 0
is: SBO:0000247

metaM HC02179 e
constant: false
initial amount: NaN
name: 20-hydroxy-arachidonate
initial concentration: 1.0
is: CHEBI:34306
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_a1f897ef_7697_4265_8378_a4bacf375479
is encoded by: hsa:5152
initial amount: NaN
constant: false
name: PDE9A
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN

metaR EX phyt LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phytanic acid exchange
type: Reaction

metaR r0722
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110054#
fast: false
product: MODEL1310110054#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/4.2.3.12
modifier: MODEL1310110054#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110054#_a8018dd4_a5fc_4cb6_a463_a282774310be
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: O15269
has only substance units: false
name: SPTLC1
constant: false
is encoded by: hsa:10558
boundary condition: true
type: Species

metaM CE3554 r
type: Species
is: CHEBI:57923
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
name: 20-trihydroxy-leukotriene-B4
notes: FORMULA: C20H31O7 CHARGE: -1 INCHI: InChI=1/C20H32O7/c21-17(11-6-2-1-5-9-16-20(25,26)27)12-7-3-4-8-13-18(22)14-10-15-19(23)24/h2-4,6-8,12-13,17-18,21-22,25-27H,1,5,9-11,14-16H2,(H,23,24)/p-1/b4-3+,6-2-,12-7+,13-8-/t17-,18-/m0/s1 EHMN_ABBREVIATION: CE3554
initial amount: NaN
is: SBO:0000247

metaM aacoa x
is: SBO:0000247
is: HMDB01484
has only substance units: false
is: CHEBI:57286
constant: false
name: acetoacetyl-CoA(4-)
initial amount: NaN
type: Species
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
initial concentration: 1.0
boundary condition: false

metaM core6 g
has only substance units: false
type: Species
constant: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
initial amount: NaN
is: CHEBI:16478
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: Core 6

http://identifiers.org/biomodels.db/MODEL1310110054#_a1a05c24_9e04_44e9_9727_92bb7f14b1dd
constant: false
boundary condition: true
name: CA6
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:765
has only substance units: false
is: Q5FC00
is: SBO:0000252

metaR RE0566C
is: SBO:0000176
fast: false
reversible: true
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
kinetic law: MODEL1310110054#
product: MODEL1310110054#
name: RE0566
type: Reaction
is described by: ECO:0000000

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaR ALAGLNexR
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110054#
reversible: true
product: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
is: SBO:0000185
name: L-alanine/glutamine reversible exchange
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_1f44ae3c_2b06_46c6_a3b7_10f922c09098
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
name: SLC43A2
boundary condition: true
is encoded by: hsa:124935
has only substance units: false
initial amount: NaN
is: Q8N370

metaR ABUTD
is: SBO:0000176
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
reactant: MODEL1310110054#
is described by: ECO:0000269
product: MODEL1310110054#
name: Aminobutyraldehyde dehydrogenase
modifier: MODEL1310110054#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
type: Reaction

metaM hs deg22 l
notes: FORMULA: C37H56NO35S CHARGE: -3
has only substance units: false
initial amount: NaN
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
constant: false
is: SBO:0000247
type: Species
is: HMDB02704
is: CHEBI:21338
initial concentration: 1.0
boundary condition: false

metaM dnad c
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
boundary condition: false
is: C00857
is: CHEBI:18304
is: SBO:0000247
initial concentration: 1.0
is: HMDB01179
has only substance units: false
initial amount: NaN
name: Deamino-NAD+
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_c6df3cb2_ae64_4c0f_97a2_6078e83db74c
is: B3KVI7
constant: false
is encoded by: hsa:3712
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
name: IVD
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_0f94ab72_f058_4b7c_b8a7_b6ca7a277679
is encoded by: hsa:6526
is: P53794
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: SLC5A3
boundary condition: true
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_c38ae264_74ef_4818_9bb8_4fc28ce43a50
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:3157
name: HMGCS1

metaM pmtcrn c
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
name: L-palmitoylcarnitine
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:17490
is: HMDB00222
boundary condition: false

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaM 4ppcys m
type: Species
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: SBO:0000247
has only substance units: false
is: CHEBI:59458
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB01117
boundary condition: false
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)

metaR r0899
fast: false
product: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
name: Amino acid transporter ATB0+ Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110054#
is: SBO:0000185
reversible: true

metaR LTA4H
name: Leukotriene A-4 hydrolase
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
kinetic law: MODEL1310110054#
is: SBO:0000176
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.3.2.6
reactant: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
is described by: ECO:0000134
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110054#_9724f185_9349_4787_b105_2dcacbee877c
type: Species
name: NDUFA8
is encoded by: hsa:4702
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: B1AM93

http://identifiers.org/biomodels.db/MODEL1310110054#_59db6fe8_5636_4ee3_973c_b8934a6970cf
boundary condition: true
is encoded by: hsa:515
constant: false
name: ATP5F1
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is: P24539

metaR AG13T15g
type: Reaction
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110054#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000000

metaR GBAl
notes: GENE_ASSOCIATION: (2629.4) or (2629.1) or (2629.3) or (2629.2) or (2629.5) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 4 AUTHORS: PMID:11933202,PMID:12667141 NOTES:NJ
reversible: false
kinetic law: MODEL1310110054#
is: SBO:0000176
modifier: MODEL1310110054#
product: MODEL1310110054#
name: Glucosylceramidase
is version of: http://identifiers.org/ec-code/3.2.1.45
fast: false
reactant: MODEL1310110054#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110054#_ad23c8ed_80c1_48a2_b8d4_c8c940a58164
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:79143
is: Q96N66
name: MBOAT7

metaR r0720
is: SBO:0000176
kinetic law: MODEL1310110054#
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110054#
fast: false

metaM retn r
boundary condition: false
is: HMDB01852
name: all-trans-retinoate
is: CHEBI:35291
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
has only substance units: false
is: SBO:0000247
type: Species

metaM xol7ah2 c
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: CHEBI:28047
name: 5beta-cholestane-3alpha,7alpha-diol
is: HMDB06893

metaR RTOTAL2t
name: RTOTAL2 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000185
type: Reaction
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_5ebc4440_9222_48bb_a125_1cfa557cbc29
type: Species
constant: false
is encoded by: hsa:27124
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: INPP5J
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_3b3b8dc8_09b8_453f_adff_af42bed2b093
is: Q5JAM2
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
name: ALAS1
is encoded by: hsa:211
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_3c44b732_f1e2_4aa3_9d1b_92b5c15159a6
type: Species
has only substance units: false
name: CHKB
initial concentration: NaN
is: Q9Y259
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:1120

http://identifiers.org/biomodels.db/MODEL1310110054#_20d33252_c6de_40c2_bf2c_8d502a301eac
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:954
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: ENTPD2
type: Species
is: Q5SPY7

metaR r1527
kinetic law: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.1
product: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_45fc2b73_593f_4065_b555_45dc4db5f6a6
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: E7EPT3
is encoded by: hsa:501
initial concentration: NaN
constant: false
name: ALDH7A1

metaR RE1531M
kinetic law: MODEL1310110054#
is described by: ECO:0000000
name: RE1531
modifier: MODEL1310110054#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
product: MODEL1310110054#
reactant: MODEL1310110054#
fast: false

metaM c14dccoa x
boundary condition: false
name: tetradecanedioylcoa
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C35H55N7O19P3S CHARGE: -5
is: HMDB02288

http://identifiers.org/biomodels.db/MODEL1310110054#_0c37c947_686f_4e48_a5fd_d942033f43e3
name: DPM2
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is: O94777
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8818

metaM 4aphdob c
has only substance units: false
is: CHEBI:58147
boundary condition: false
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
type: Species
initial amount: NaN
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
constant: false
is: SBO:0000247
is: HMDB00978
initial concentration: 1.0

metaR PROSTGD2t
reversible: true
name: prostaglandin transport via bicarbonate countertransport
type: Reaction
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110054#
is: SBO:0000185
product: MODEL1310110054#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110054#
modifier: MODEL1310110054#

metaR r0871
name: Diffusion
product: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409 NOTES:
type: Reaction
reactant: MODEL1310110054#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_92a9a1af_ec10_451d_86dd_c1aa1eeff59f
has only substance units: false
initial amount: NaN
name: PANK3
is encoded by: hsa:79646
boundary condition: true
is: Q9H999
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN

metaM 3mgcoa m
is: HMDB01057
name: trans-3-methylglutaconyl-CoA(5-)
initial amount: NaN
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
initial concentration: 1.0
is: CHEBI:57346
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species

metaM dttp n
is: C00459
constant: false
name: dTTP
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01342
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
type: Species
boundary condition: false
is: CHEBI:37568

metaR r0726
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.33
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110054#
fast: false
modifier: MODEL1310110054#
reversible: true
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176
is described by: ECO:0000000

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_a77b6b94_8103_4258_9d03_766372dad982
is: P05091
initial concentration: NaN
name: ALDH2
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:217
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_f9b28ec1_0a57_4051_938c_635db7cc29fa
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2629
name: GBA
boundary condition: true
type: Species
is: B7Z6S9
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_2ad44fc5_7511_4290_ae71_e2f31609de77
is encoded by: hsa:AV717590
constant: false
name: _AV717590_1_m
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM glc D r
is: HMDB00122
is: CHEBI:4167
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: D-glucose
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_7c15c8b7_b9cc_4b27_ad6b_eeaa2461b6ad
is: P25705
has only substance units: false
name: ATP5A1
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:498

http://identifiers.org/biomodels.db/MODEL1310110054#_1cdd17c9_6651_496e_92b7_99e883d757dc
type: Species
is encoded by: hsa:AI539321
name: _AI539321_1_c
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_769da5de_d8f4_43cf_b305_a5437b2dde52
has only substance units: false
initial concentration: NaN
name: ATIC
type: Species
constant: false
is: SBO:0000252
is: P31939
is encoded by: hsa:471
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_f9c4031c_8e75_4116_ae20_1c74e022eade
initial amount: NaN
initial concentration: NaN
name: MTHFD2L
has only substance units: false
type: Species
is encoded by: hsa:441024
is: SBO:0000252
is: Q9H903
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_cfe8fd24_6f90_4699_b565_822c872fb569
is: SBO:0000252
is: Q53Y83
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
name: GLA
constant: false
initial amount: NaN
is encoded by: hsa:2717

metaM CE5121 m
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:57449
name: trans-3-decenoyl-CoA

metaR r0892
is version of: http://identifiers.org/ec-code/3.1.2.27
name: Facilitated diffusion
reversible: true
fast: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
type: Reaction
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110054#

metaR CGLYt3 2
product: MODEL1310110054#
reversible: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000304
fast: false
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
name: Cys-Gly transport in via proton symport
modifier: MODEL1310110054#

metaR r0870
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.1.1
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.7.72
product: MODEL1310110054#
fast: false
type: Reaction
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.6.4.13
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.4
reversible: true
reactant: MODEL1310110054#

metaR r0724
is: SBO:0000176
modifier: MODEL1310110054#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110054#
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.1.33
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110054#

metaR GALASE4ly
reactant: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
reversible: false
kinetic law: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaM HC02179 c
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:34306
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial concentration: 1.0
boundary condition: false
name: 20-hydroxy-arachidonate

metaR FUMAC
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.7.1.2
reactant: MODEL1310110054#
modifier: MODEL1310110054#
product: MODEL1310110054#
reversible: false
name: fumarylacetoacetase
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110054#

metaR r0160
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
reversible: false
product: MODEL1310110054#
is described by: ECO:0000000
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
is version of: http://identifiers.org/ec-code/2.1.3.2
reactant: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000176
type: Reaction
fast: false

metaR SADT
name: sulfate adenylyltransferase
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000269
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.1.25
reactant: MODEL1310110054#

metaR PDE1
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.17
product: MODEL1310110054#
is described by: ECO:0000269
reactant: MODEL1310110054#
modifier: MODEL1310110054#
name: 3',5'-cyclic-nucleotide phosphodiesterase
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.4.35
reversible: false
kinetic law: MODEL1310110054#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_2e72b50c_4712_4578_9c64_34500eb4985e
is encoded by: hsa:2987
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q16774
type: Species
name: GUK1
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_158b2ec6_40a2_4d99_a370_34ad554d5d76
initial amount: NaN
name: SLC16A10
constant: false
type: Species
is: Q8TF71
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:117247
is: SBO:0000252

metaM ksi deg9 l
has only substance units: false
is: HMDB00143
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
is: SBO:0000247
name: keratan sulfate I, degradation product 9
initial amount: NaN
initial concentration: 1.0
is: CHEBI:12936
constant: false
type: Species
boundary condition: false

metaM xoldiolone r
is: CHEBI:28477
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB02197
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
is: SBO:0000247
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
constant: false
boundary condition: false
type: Species

metaM sucsal m
type: Species
is: CHEBI:57706
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
is: HMDB01259
boundary condition: false
name: Succinic semialdehyde

metaR r0723
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
modifier: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
is version of: http://identifiers.org/ec-code/2.3.1.41
reactant: MODEL1310110054#
reversible: false
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_ae2ecff5_b123_40c1_9571_62794af1718d
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: Q9HC21
name: SLC25A19
initial amount: NaN
is encoded by: hsa:60386
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_95558799_55aa_46c5_9bb6_89a0d03bddf2
is encoded by: hsa:AI926493
type: Species
constant: false
is: SBO:0000252
boundary condition: true
name: _AI926493_1_c
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM CE2417 m
type: Species
initial amount: NaN
is: SBO:0000247
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
is: HMDB11123
initial concentration: 1.0
is: CHEBI:28387
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
constant: false
boundary condition: false
has only substance units: false

metaR ASAH1
reactant: MODEL1310110054#
product: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.23
kinetic law: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
reversible: false
name: N-acylsphingosine amidohydrolase
modifier: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (427.1) or (427.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.5.1.23 Confidence Level: 4 AUTHORS: PMID:8955159 NOTES:NJ

metaR ORNt4m
modifier: MODEL1310110054#
reversible: true
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000185
name: ornithine mitochondrial transport exchange with citruline
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
reactant: MODEL1310110054#
fast: false

metaM tsul m
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
name: thiosulfate(2-)
initial concentration: 1.0
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: CHEBI:16094
is: HMDB00257
initial amount: NaN
type: Species

metaM dmnoncoa c
type: Species
boundary condition: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
initial amount: NaN
constant: false
is: HMDB11604
is: SBO:0000247
name: 4,8 dimethylnonanoyl-CoA
initial concentration: 1.0
has only substance units: false

metaM core6 l
type: Species
constant: false
is: CHEBI:12936
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C16H27N2O10X CHARGE: 0
name: Core 6
is: SBO:0000247
is: HMDB00143
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_ee87873d_72f0_4cef_a532_8f8b88588df1
constant: false
initial concentration: NaN
is: Q709F0
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:84129
has only substance units: false
name: ACAD11
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_5b2aaeba_3d4f_423d_9f65_53590c562876
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: P50226
initial amount: NaN
name: SULT1A2
is: SBO:0000252
is encoded by: hsa:6799
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_6d0d2699_cbc0_45d0_a11e_6aeca912dee9
boundary condition: true
initial amount: NaN
is: Q13825
name: AUH
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:549
constant: false

metaR MM5cg
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
fast: false
type: Reaction
product: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reversible: false
reactant: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.113

http://identifiers.org/biomodels.db/MODEL1310110054#_6ba141d4_0f13_42a3_b7dd_b6c60432bc38
constant: false
is: Q5DSZ6
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
name: UGT1A8
boundary condition: true
is: SBO:0000252
is encoded by: hsa:54576

metaM xol7ah2 m
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: CHEBI:28047
name: 5beta-cholestane-3alpha,7alpha-diol
constant: false
is: HMDB06893
initial amount: NaN
type: Species
has only substance units: false

metaR FADtx
fast: false
type: Reaction
product: MODEL1310110054#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110054#
name: FAD transporter, peroxisomal
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110054#_b7f143f3_2785_45fb_b81a_f4fe84870a01
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:506
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: ATP5B
is: P06576
type: Species

metaM ksi pre4 g
name: keratan sulfate I biosynthesis, precursor 4
is: CHEBI:58053
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00175
initial amount: NaN
is: C00130
boundary condition: false
type: Species
notes: FORMULA: C101H165N7O72X CHARGE: -1

metaR ALASm
reversible: false
is described by: ECO:0000254
product: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
name: 5-aminolevulinate synthase
is version of: http://identifiers.org/ec-code/2.3.1.37
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.29
is: SBO:0000176
reactant: MODEL1310110054#

metaM ksi deg13 l
initial amount: NaN
boundary condition: false
name: keratan sulfate I, degradation product 13
type: Species
is: CHEBI:16953
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00812
notes: FORMULA: C174H280N12O150S8 CHARGE: -8

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaM 4ppcys c
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:59458
type: Species
boundary condition: false
has only substance units: false
is: HMDB01117
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
is: C04352
initial concentration: 1.0

metaM hs deg8 l
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
is: SBO:0000247
is: CHEBI:15748
is: HMDB00127
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: heparan sulfate, degradation product 8
type: Species
has only substance units: false
constant: false

metaM 2oxoadp m
name: 2-oxoadipate(2-)
is: SBO:0000247
is: HMDB00225
type: Species
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
boundary condition: false
initial concentration: 1.0
is: CHEBI:57499

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_811ed7d6_db5f_459e_ae7e_6302eca77fe3
boundary condition: true
is encoded by: hsa:5144
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q08499
name: PDE4D
type: Species
has only substance units: false
constant: false

metaR DESAT22 2p
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_6dc9c054_2ebb_4ed7_bf0a_f3a8c39cffc2
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:C7orf24
name: _C7orf24_1_m
constant: false
boundary condition: true
type: Species
initial concentration: NaN

metaR r2032
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110054#
is described by: ECO:0000000
product: MODEL1310110054#
is: SBO:0000185
reversible: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaM g1m8mpdol U r
has only substance units: false
constant: false
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:59093
is: SBO:0000247
notes: FORMULA: C1785H2940N20O670P20 CHARGE: -20

metaR r0464
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
product: MODEL1310110054#
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
reversible: true

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaM clpn hs c
has only substance units: false
initial amount: NaN
is: HMDB02704
is: CHEBI:21338
is: SBO:0000247
name: clpn_hs[c]
constant: false
boundary condition: false
type: Species
notes: FORMULA: CHARGE: 0
initial concentration: 1.0

metaM C04849 e
initial amount: NaN
initial concentration: 1.0
type: Species
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
is: CHEBI:57449
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247

metaM 3decdicoa m
is: SBO:0000247
boundary condition: false
name: 3,7-decadienoylcoa
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_9c4b61e7_d863_424b_9898_a1940c070ac2
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: ALG3
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:10195

metaR RE3244R
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
product: MODEL1310110054#
modifier: MODEL1310110054#
name: RE3244
fast: false
reversible: true
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_54d4c3bd_75bd_4c59_b2b6_b481cf22fc57
initial concentration: NaN
boundary condition: true
is: O00217
is encoded by: hsa:4728
type: Species
name: NDUFS8
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_ea189dfc_b20f_4460_a0cf_008dc2472503
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:9962
type: Species
boundary condition: true
name: SLC23A2

metaM xol7ah2al m
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
boundary condition: false
type: Species
constant: false
has only substance units: false
is: CHEBI:27428
initial concentration: 1.0
is: SBO:0000247
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: HMDB06894
initial amount: NaN

metaR 3MOX4HOXPGALDOX NADP
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase
type: Reaction
modifier: MODEL1310110054#
is: SBO:0000176
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110054#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110054#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110054#_3be925d3_06b8_4325_a22c_3dac48490785
is encoded by: hsa:4831
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: P22392
is: SBO:0000252
boundary condition: true
name: NME2
constant: false

metaR AKR1D2
fast: false
type: Reaction
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000269
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.3.1.3
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
reactant: MODEL1310110054#

metaR r0051
type: Reaction
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
is version of: http://identifiers.org/ec-code/3.1.3.5
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
modifier: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110054#_4e17b7f7_2af4_4260_8bdd_2458fd17ff3b
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:AA081045
has only substance units: false
name: _AA081045_1_m
is: SBO:0000252
boundary condition: true

metaM CE5116 x
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,19-20,28-30,34-36,40,51-52H,4-7,10,13,16-18,21-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,20-19+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE5116
initial amount: NaN
is: CHEBI:57923
has only substance units: false
name: trans-3-cis-8,11,14-eicosatetraenoyl-CoA
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_08c4a4b9_7fc1_430d_9232_49e4f62b5e55
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
name: PDE9A
is encoded by: hsa:5152

http://identifiers.org/biomodels.db/MODEL1310110054#_1a0dd8d4_795e_4108_bfc2_8c6b5b70478f
boundary condition: true
type: Species
initial concentration: NaN
name: GCSH
has only substance units: false
is: SBO:0000252
constant: false
is: P23434
initial amount: NaN
is encoded by: hsa:2653

http://identifiers.org/biomodels.db/MODEL1310110054#_dadcdedf_3b81_458a_b9c2_c33580a444b3
constant: false
boundary condition: true
name: NMNAT2
is encoded by: hsa:23057
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR ADEt
kinetic law: MODEL1310110054#
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110054#
modifier: MODEL1310110054#
reversible: true
name: adenine reversible transport, cytosol

metaR S6T9g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
product: MODEL1310110054#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110054#_6e562448_6dcb_44a8_b701_fa197d7914fd
is encoded by: hsa:3417
boundary condition: true
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: O75874
name: IDH1
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_95e905fb_04b9_4afa_b085_01587e3455da
constant: false
initial amount: NaN
name: _AI285872_1_c
boundary condition: true
has only substance units: false
is encoded by: hsa:AI285872
is: SBO:0000252
initial concentration: NaN
type: Species

metaR THRGLNNaEx
reactant: MODEL1310110054#
fast: false
modifier: MODEL1310110054#
is: SBO:0000185
kinetic law: MODEL1310110054#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110054#
name: L-threonine/L-glutamine Na-dependent exchange (Thr-L in)
type: Reaction

metaM CE0785 m
is: SBO:0000247
has only substance units: false
name: cis,cis-myristo-5,8-dienoyl-CoA
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:57795
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
type: Species
initial amount: NaN

metaM Rtotal3 e
initial concentration: 1.0
is: CHEBI:3554
notes: FORMULA: CO2FULLR3 CHARGE: -1
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
type: Species
name: R total 3 position
is: HMDB00244
boundary condition: false
is: C00255

metaR r2034
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110054#
reversible: false
is: SBO:0000185
fast: false
type: Reaction
modifier: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_0d3583f1_56aa_436c_993d_1572aac2b36e
is encoded by: hsa:517
type: Species
constant: false
name: ATP5G2
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR EX whhdca LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: omega hydroxy hexadecanoate (n-C16:0) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_771798f3_32f4_43a1_bc18_7810ccc7bdbb
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:55902
is: Q5QPH3
is: SBO:0000252
name: ACSS2
type: Species
has only substance units: false
constant: false

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaR PMANM
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/5.4.2.8
modifier: MODEL1310110054#
type: Reaction
name: phosphomannomutase
is version of: http://identifiers.org/ec-code/5.4.2.2
fast: false
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110054#_49e577a4_07cf_4617_9932_0edf12ec1cde
boundary condition: true
name: DGKE
is: A1L4Q0
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:8526
is: SBO:0000252

metaR FACOAL206
is described by: ECO:0000269
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110054#
fast: false
is: SBO:0000176
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
name: fatty-acid--CoA ligase

metaR HACD9m
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
product: MODEL1310110054#
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
is: SBO:0000176
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
reversible: true
modifier: MODEL1310110054#
type: Reaction

metaM 6dhf e
constant: false
boundary condition: false
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
initial concentration: 1.0
has only substance units: false
is: HMDB06563
type: Species
initial amount: NaN
is: SBO:0000247
name: hexaglutamyl folate (DHF)

http://identifiers.org/biomodels.db/MODEL1310110054#_2e7623b0_1a84_4355_bb33_cb5955bd6c94
type: Species
has only substance units: false
is encoded by: hsa:52
boundary condition: true
is: SBO:0000252
name: ACP1
initial amount: NaN
initial concentration: NaN
constant: false
is: B5MCC7

metaR RE0577C
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false
modifier: MODEL1310110054#
name: RE0577
reversible: true
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
type: Reaction
reactant: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
is: SBO:0000176
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.1.2.2

metaR MMSAD3m
is: SBO:0000176
kinetic law: MODEL1310110054#
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.27
fast: false
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
product: MODEL1310110054#

metaR GASNASE3ly
kinetic law: MODEL1310110054#
is described by: ECO:0000000
name: glycosylasparaginase, lysosomal
reactant: MODEL1310110054#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.26
is: SBO:0000176
modifier: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD

metaM dhbpt c
has only substance units: false
name: 6,7-dihydrobiopterin
initial amount: NaN
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
type: Species
is: CHEBI:20680
boundary condition: false
is: HMDB00038
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM ksii core4 pre7 g
notes: FORMULA: C75H121N6O56SX CHARGE: -2
initial amount: NaN
is: C00130
has only substance units: false
is: SBO:0000247
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 7
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00175

metaM 25aics c
type: Species
initial concentration: 1.0
is: C04823
boundary condition: false
has only substance units: false
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
is: CHEBI:58443
is: HMDB00797
is: SBO:0000247
initial amount: NaN
constant: false
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate

metaM tsul c
is: HMDB00257
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
is: CHEBI:16094
name: thiosulfate(2-)
initial concentration: 1.0
boundary condition: false
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaR ALADGLYexR
is: SBO:0000185
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
fast: false
name: D-alanine/glycine reversible exchange
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_8f7e9f63_44c2_40ba_8dd7_32f82f14c15e
constant: false
is encoded by: hsa:55276
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
name: PGM2
is: Q96G03
is: SBO:0000252
initial amount: NaN

metaR SPHINGStl
kinetic law: MODEL1310110054#
type: Reaction
name: sphingosine intracellular transport
reversible: true
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however sphingosine manages to get in different compartments of cells. NOT presumed to be flip-flop. NJ
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110054#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_d46a1cf6_fd92_4012_b32b_a06c25edb90b
constant: false
boundary condition: true
is: P48728
is encoded by: hsa:275
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: AMT
initial amount: NaN

metaR ALAt2r
name: L-alanine reversible transport via proton symport
reactant: MODEL1310110054#
is described by: ECO:0000304
type: Reaction
is: SBO:0000185
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reversible: true
product: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_717aefb6_1abc_4c99_ab0d_38ad213c9476
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
type: Species
boundary condition: true
name: ST3GAL3
is encoded by: hsa:6487
is: SBO:0000252

metaR RE2973C
reactant: MODEL1310110054#
fast: false
is: SBO:0000176
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.1.137
product: MODEL1310110054#
name: RE2973
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.154

metaM glc D l
constant: false
initial concentration: 1.0
is: CHEBI:4167
is: SBO:0000247
name: D-glucose
is: HMDB00122
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040

metaR CERT2gt
reactant: MODEL1310110054#
product: MODEL1310110054#
name: ceramide transport protein
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reversible: true
is: SBO:0000185
modifier: MODEL1310110054#

metaR r0463
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000000
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
is: SBO:0000176

metaR r1418
is: SBO:0000176
product: MODEL1310110054#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reversible: true
type: Reaction
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1

metaR OIVD1m
name: 2-oxoisovalerate dehydrogenase (acylating; 4-methyl-2-oxopentaoate), mitochondrial
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.168
reversible: false
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
is: SBO:0000176
modifier: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.4
fast: false
reactant: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.2.4.4

metaR GALt4
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000185
reversible: true
fast: false
name: galactose transport via sodium symport
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_f2789035_05d1_4a75_be6f_3eda44644d1c
is encoded by: hsa:5137
type: Species
initial concentration: NaN
initial amount: NaN
name: PDE1C
boundary condition: true
is: Q8NB10
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_438f030c_a7fc_45e3_9b0a_f57939cf3cb6
constant: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
name: SLC22A2
is: O15244
is encoded by: hsa:6582
has only substance units: false
is: SBO:0000252

metaR FACOAL204
product: MODEL1310110054#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
name: fatty-acid--CoA ligase
fast: false
is: SBO:0000176
reactant: MODEL1310110054#

metaM aacoa m
initial concentration: 1.0
name: acetoacetyl-CoA(4-)
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
is: HMDB01484
type: Species
is: CHEBI:57286
boundary condition: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332

http://identifiers.org/biomodels.db/MODEL1310110054#_metaR_ACGALFUCGALACGALFUC12GAL14ACGLCGALGLUSIDEte
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
reversible: true
product: MODEL1310110054#
name: blood group intracellular transport
kinetic law: MODEL1310110054#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaM dmnoncoa m
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB11604
constant: false
initial concentration: 1.0
boundary condition: false
name: 4,8 dimethylnonanoyl-CoA
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1

metaR RTOTAL3FATPc
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal3 by enterocytes
type: Reaction

metaM bildglcur r
name: bis(beta-glucosyluronate)bilirubin
initial amount: NaN
is: CHEBI:58471
boundary condition: false
is: HMDB03325
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
type: Species
initial concentration: 1.0

metaM xol7aone r
is: HMDB01993
has only substance units: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
constant: false
initial concentration: 1.0
name: 7alpha-hydroxycholest-4-en-3-one
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:17899
boundary condition: false

metaM 2dr5p c
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: 2-deoxy-D-ribose 5-phosphate(2-)
type: Species
is: CHEBI:57651
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB01031
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673

metaR C4STMO2Pr
reversible: false
fast: false
kinetic law: MODEL1310110054#
name: C-4 methyl sterol oxidase
modifier: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.1.1.170
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
is: SBO:0000176
type: Reaction
reactant: MODEL1310110054#

metaR GLCNACASE5ly
reactant: MODEL1310110054#
product: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
name: alpha-N-acetylglucosaminidase, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.50
is described by: ECO:0000000
modifier: MODEL1310110054#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110054#

metaR ASPPROASCT1
fast: false
reactant: MODEL1310110054#
modifier: MODEL1310110054#
reversible: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110054#
product: MODEL1310110054#
name: aspartate intake by system ASCT-1 transporter

metaR SO4tl
reactant: MODEL1310110054#
reversible: true
name: Sulfate transport (lysosome)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110054#
type: Reaction
product: MODEL1310110054#

metaR r2030
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110054#
product: MODEL1310110054#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
reversible: false
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110054#_4edc9351_1d68_4a56_a715_24b66c23e94b
is: SBO:0000252
is: O14832
name: PHYH
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:5264
initial amount: NaN

metaR P45027A11m
modifier: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
is: SBO:0000176
kinetic law: MODEL1310110054#
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
is described by: ECO:0000269
reactant: MODEL1310110054#
product: MODEL1310110054#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_7bd51db8_05c0_4045_a827_129e850986d3
is encoded by: hsa:6482
initial concentration: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
name: ST3GAL1
is: SBO:0000252
initial amount: NaN

metaR DHCR71r
is: SBO:0000176
modifier: MODEL1310110054#
reversible: false
kinetic law: MODEL1310110054#
is described by: ECO:0000134
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
is version of: http://identifiers.org/ec-code/1.3.1.21
name: 7-dehydrocholesterol reductase
fast: false
type: Reaction
reactant: MODEL1310110054#

metaM ksi pre13 g
constant: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 13
is: CHEBI:58053
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: C00130
is: HMDB00175
initial amount: NaN

metaM ksi pre26 g
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
has only substance units: false
type: Species
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 26
initial amount: NaN
initial concentration: 1.0

metaR r2028
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: false
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#

metaM btcoa x
is: C00136
is: HMDB01088
constant: false
has only substance units: false
initial concentration: 1.0
name: Butanoyl-CoA
type: Species
notes: FORMULA: C25H38N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR r0157
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
type: Reaction
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/6.3.4.2
reactant: MODEL1310110054#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
fast: false
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_metaR_ACGALFUCGALACGALFUC12GAL14ACGLCGALGLUSIDEtg
name: blood group intracellular transport
reversible: true
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
reactant: MODEL1310110054#
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110054#
is: SBO:0000185

metaR 3MOX4HOXPGALDOX
reactant: MODEL1310110054#
reversible: false
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000176
is described by: ECO:0000304
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_481b23a2_59aa_4493_966e_aabfd3d795ff
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P21108
type: Species
name: PRPS1L1
constant: false
is encoded by: hsa:221823
has only substance units: false

metaR CYSTHRNaEx
name: L-cysteine/L-threonine Na-dependent exchange (Cys-L in)
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000269
reactant: MODEL1310110054#
reversible: false
modifier: MODEL1310110054#
is: SBO:0000185

metaR UAGALDP
reactant: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
reversible: false
kinetic law: MODEL1310110054#
name: UDP-N-acetylgalactosamine diphosphorylase

http://identifiers.org/biomodels.db/MODEL1310110054#_d808a38e_92a5_4b16_91fe_e9cc8cc111d8
has only substance units: false
name: ATP5J
type: Species
initial amount: NaN
is encoded by: hsa:522
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252

metaM pmtcrn r
boundary condition: false
name: L-palmitoylcarnitine
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: CHEBI:17490
is: SBO:0000247
is: HMDB00222
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990

metaR OIVD2m
is version of: http://identifiers.org/ec-code/1.2.4.4
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.8.1.4
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.168
reversible: false
name: 2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxobutanoate), mitochondrial
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_ee19dd60_18bc_4374_be5f_8ea0c92027e2
is encoded by: hsa:154091
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is: Q8TD20
name: SLC2A12
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR NACASPAH
reversible: false
type: Reaction
product: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (443.1) or (91703.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.15 Confidence Level: 4 AUTHORS: PMID:8252036 NOTES:SAB
kinetic law: MODEL1310110054#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.1.15
modifier: MODEL1310110054#
name: N-Acetyl-L-aspartate amidohydrolase

metaR RE2974C
reversible: true
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.1.68
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
name: RE2974
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.1.149

metaM cpppg3 c
initial amount: NaN
has only substance units: false
name: Coproporphyrinogen III
constant: false
initial concentration: 1.0
notes: FORMULA: C36H40N4O8 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01085 EHMN_ABBREVIATION: C03263
is: HMDB01261
type: Species
is: CHEBI:57309
boundary condition: false
is: SBO:0000247
is: C03263

metaR STRDNCt
name: fatty acid transport via diffusion
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110054#
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_32e99662_104c_4d10_b4b6_959df21b2411
name: ALPP
constant: false
type: Species
boundary condition: true
is encoded by: hsa:250
initial amount: NaN
has only substance units: false
is: P05187
is: SBO:0000252
initial concentration: NaN

metaM 3mob m
is: HMDB00019
is: CHEBI:11851
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
boundary condition: false
constant: false
type: Species
has only substance units: false
is: SBO:0000247
name: 3-methyl-2-oxobutanoate

metaM trdrd c
name: Reduced thioredoxin
is: C00342
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
constant: false
is: CHEBI:15967
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_980a984a_3242_42b8_aea7_99a9b1e8d7c8
has only substance units: false
initial concentration: NaN
type: Species
is: O15382
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:587
initial amount: NaN
name: BCAT2

metaM mal L m
boundary condition: false
initial amount: NaN
name: (S)-malate(2-)
constant: false
type: Species
is: SBO:0000247
is: HMDB00156
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: CHEBI:15589

http://identifiers.org/biomodels.db/MODEL1310110054#_b296a165_71eb_4e8c_808f_c31dd752fd25
type: Species
constant: false
is: Q9H5J4
is encoded by: hsa:79071
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: ELOVL6

metaM HC01610 e
initial concentration: 1.0
constant: false
name: CoproporphyrinogenI
is: SBO:0000247
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:28607
initial amount: NaN

metaR DOLPMT L
name: Dolichyl-phosphate D-mannosyltransferase (liver)
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.1.83
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
reactant: MODEL1310110054#
reversible: false
type: Reaction
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110054#_95cc1ca0_1d60_4ec9_9460_87113a2ecefa
initial concentration: NaN
name: NDUFS5
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
is: Q6IBA0
boundary condition: true
has only substance units: false
is encoded by: hsa:4725

metaR FAOXC101C102x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)x
type: Reaction

metaR FACOAL160i
name: C160 fatty acid activation
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110054#
is: SBO:0000176
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
modifier: MODEL1310110054#
reversible: false
reactant: MODEL1310110054#

metaM 3docopencoa x
boundary condition: false
initial amount: NaN
has only substance units: false
name: 3,7,10,13,16-docosapentenoylcoa
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110054#_e20cf8ef_73dc_4521_b9ae_bbd5181b8706
constant: false
initial concentration: NaN
has only substance units: false
name: _22305_1_c
type: Species
initial amount: NaN
is encoded by: hsa:22305
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_17f80253_b1f7_458c_b25a_a60707cfd4e7
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5152
name: PDE9A
constant: false
type: Species

metaR AMPtp
product: MODEL1310110054#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
reversible: true
type: Reaction
reactant: MODEL1310110054#
is: SBO:0000185
kinetic law: MODEL1310110054#
name: AMP transporter, peroxisome

metaM gacpail hs c
type: Species
initial concentration: 1.0
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
initial amount: NaN
boundary condition: false
name: glucosaminyl-acylphosphatidylinositol
is: C01236
is: HMDB01127
is: CHEBI:57955
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_f06929d1_4831_4c29_9df8_11e6f559377b
is: SBO:0000252
type: Species
is: Q16831
name: UPP1
initial amount: NaN
is encoded by: hsa:7378
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false

metaR GALASE7ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
name: beta-galactosidase, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110054#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR 2HBO
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110054#
type: Reaction
fast: false
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.1.1.27
kinetic law: MODEL1310110054#

metaM ksi pre2 g
notes: FORMULA: C87H142N6O62X CHARGE: -1
type: Species
is: HMDB00175
initial amount: NaN
boundary condition: false
constant: false
is: C00130
name: keratan sulfate I biosynthesis, precursor 2
has only substance units: false
is: CHEBI:58053
initial concentration: 1.0
is: SBO:0000247

metaR CYSGLYexR
name: L-cysteine/glycine reversible exchanger
fast: false
reactant: MODEL1310110054#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT

metaM thbpt c
is: CHEBI:15372
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB00027
name: 5,6,7,8-tetrahydrobiopterin
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR FAOXC225C226x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_c2702be6_b00c_4b38_95fd_e45d58255c54
name: PANK3
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:79646
has only substance units: false
is: Q9H999
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_3b33996d_2a79_48e4_9119_bde88f9b0593
type: Species
is: Q9NS18
constant: false
initial concentration: NaN
name: GLRX2
is encoded by: hsa:51022
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false

metaR BHBt
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110054#
is: SBO:0000185
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_1d30364c_6a13_4326_a8d1_27ad1490b1a3
is: SBO:0000252
type: Species
is encoded by: hsa:6523
name: SLC5A1
constant: false
initial concentration: NaN
is: P13866
has only substance units: false
initial amount: NaN
boundary condition: true

metaM retn c
boundary condition: false
name: all-trans-retinoate
type: Species
initial concentration: 1.0
is: HMDB01852
is: CHEBI:35291
constant: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_202b2214_8836_449c_87a5_53800ceff4ce
constant: false
is encoded by: hsa:8854
name: ALDH1A2
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: O94788
type: Species
initial concentration: NaN
has only substance units: false

metaM idour e
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: SBO:0000247
constant: false
is: HMDB02704
is: CHEBI:21338
name: L-iduronate
type: Species
initial concentration: 1.0

metaR H4ETer
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000176
type: Reaction
name: H4 phosphoethanolaminyl transferase, endoplasmic reticulum
reversible: false
fast: false

metaR B3GNT32g
modifier: MODEL1310110054#
is described by: ECO:0000269
reactant: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
reversible: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is: SBO:0000176
product: MODEL1310110054#

metaR r1998
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110054#
is: SBO:0000185
kinetic law: MODEL1310110054#
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_2f43fb88_54f3_453b_8b7f_27ba9dbeb02e
type: Species
name: MPST
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:4357
is: P25325
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_6497b6db_ab1c_4696_8edf_ef769fe7c882
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q96RN1
constant: false
name: SLC26A8
type: Species
is encoded by: hsa:116369

metaM pa hs m
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
name: phosphatidate(2-)
is: CHEBI:57739

metaR ASNCYSNaEx
type: Reaction
product: MODEL1310110054#
reversible: false
kinetic law: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
is described by: ECO:0000269
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)

metaM glc D e
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
initial concentration: 1.0
is: CHEBI:4167
type: Species
is: HMDB00122
constant: false
has only substance units: false
name: D-glucose
initial amount: NaN
boundary condition: false

metaM ksi deg4 l
is: SBO:0000247
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
constant: false
is: HMDB00868
name: keratan sulfate I, degradation product 4
type: Species
is: CHEBI:57737
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_3d624b72_6226_4532_8c59_fccc0c57c9e1
initial amount: NaN
initial concentration: NaN
name: _AA576959_1_c
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:AA576959
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_bb0cf6da_e98c_4b13_affd_60b8ba394319
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaM pa hs n
constant: false
type: Species
name: phosphatidate(2-)
initial concentration: 1.0
boundary condition: false
is: CHEBI:57739
has only substance units: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_2d450830_ff2e_4798_9cc6_e675b88f449f
is: P82251
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
name: SLC7A9
type: Species
is encoded by: hsa:11136

metaM glc D c
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: HMDB00122
name: D-glucose
is: CHEBI:4167
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_d01f21de_6dea_4c91_a0fa_27d25e7270dc
is: Q9Y233
is encoded by: hsa:10846
type: Species
is: SBO:0000252
name: PDE10A
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

metaR FUT911g
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
is: SBO:0000176
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.1.152
name: Alpha-(1,3)-fucosyltransferase
fast: false

metaM pmtcrn x
is: SBO:0000247
is: CHEBI:17490
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: HMDB00222
name: L-palmitoylcarnitine
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
constant: false

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaM idour c
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial concentration: 1.0
name: L-iduronate
is: CHEBI:21338
is: SBO:0000247
constant: false
type: Species
is: HMDB02704

metaM retn e
boundary condition: false
name: all-trans-retinoate
is: HMDB01852
type: Species
is: CHEBI:35291
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
has only substance units: false

metaM dgchol c
type: Species
is: CHEBI:36252
name: glycochenodeoxycholate
is: SBO:0000247
is: HMDB00637
initial concentration: 1.0
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false

metaM andrstandn r
initial amount: NaN
initial concentration: 1.0
name: 5alpha-androstane-3,17-dione
constant: false
type: Species
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
is: CHEBI:15994
is: HMDB00899
is: SBO:0000247
has only substance units: false

metaM xol7ah3 m
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:28540
type: Species
constant: false
boundary condition: false
is: HMDB12455
name: 5beta-cholestane-3alpha,7alpha,26-triol
initial concentration: 1.0

metaM gdpmann c
name: GDP-alpha-D-mannose(2-)
is: HMDB01163
constant: false
is: CHEBI:57527
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_5f420b98_2b82_4c5f_be79_ef2c3ff12abd
type: Species
is encoded by: hsa:6547
name: SLC8A3
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q96QG2
constant: false

metaM glu L m
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
has only substance units: false
initial amount: NaN
is: CHEBI:29985
is: HMDB00148
constant: false
name: L-glutamate(1-)
initial concentration: 1.0
type: Species

metaR LNLCCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine O-palmitoyltransferase
reactant: MODEL1310110054#
modifier: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000269
kinetic law: MODEL1310110054#
is: SBO:0000176
fast: false
type: Reaction
reversible: false

metaR r0717
product: MODEL1310110054#
reactant: MODEL1310110054#
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110054#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false

metaR RE3245C
type: Reaction
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
product: MODEL1310110054#
reversible: true
fast: false
name: RE3245
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_69def15e_97af_4294_af21_019cdff64510
has only substance units: false
type: Species
name: _AU149534_1_e
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:AU149534
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_c715dac7_98ef_49ca_a96a_589bbfdd9db7
is: O43708
is: SBO:0000252
is encoded by: hsa:2954
initial amount: NaN
name: GSTZ1
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
type: Species

metaM 2dodtricoa x
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: HMDB11123
name: 2,6,9-dodecatrienoylcoa
constant: false
is: C05279
initial concentration: 1.0
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: SBO:0000247

metaR MACACI
product: MODEL1310110054#
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.5.1.18
reversible: false
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
type: Reaction
name: maleylacetoacetate isomerase
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_3da1f435_1ef2_45bc_92a7_c9c22d80f72c
initial concentration: NaN
is: SBO:0000297
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
has part: P07327
is encoded by: hsa:124
name: ADH1A:ADH1B

metaM 3mob c
initial concentration: 1.0
is: CHEBI:11851
is: SBO:0000247
name: 3-methyl-2-oxobutanoate
is: HMDB00019
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141

metaR FUT16g
name: Galactoside 2-alpha-L-fucosyltransferase 1
is version of: http://identifiers.org/ec-code/2.4.1.69
product: MODEL1310110054#
fast: false
modifier: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110054#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ

metaR r0718
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.181
kinetic law: MODEL1310110054#
product: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is: SBO:0000176
reactant: MODEL1310110054#
type: Reaction
reversible: false
is described by: ECO:0000000

metaM h2o c
is: C00001
has only substance units: false
boundary condition: false
is: HMDB02111
constant: false
is: SBO:0000247
name: H2O
initial concentration: 1.0
type: Species
notes: FORMULA: H2O CHARGE: 0
is: CHEBI:3303
initial amount: NaN

metaR HSD3A2r
is: SBO:0000176
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.1.1.225
modifier: MODEL1310110054#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
fast: false
product: MODEL1310110054#
is described by: ECO:0000000

metaM CE4790 m
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
is: CHEBI:57923
initial concentration: 1.0
type: Species
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_7e3a13ad_e1df_4e60_bdc9_9aad9a338883
name: ME2
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P23368
is: SBO:0000252
type: Species
is encoded by: hsa:4200
constant: false

metaR PEROXx
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ
type: Reaction
name: peroxisomal lumped long chain fatty acid oxidation
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#

metaR HSAT2ly
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
product: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
name: heparan-glucosaminide N-acetyltransferase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110054#_6e521bfe_7d38_4bb7_9df2_1f9f0d9c6ea3
initial amount: NaN
is: P07195
initial concentration: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
name: LDHB
is encoded by: hsa:3945
is: SBO:0000252

metaM dgchol e
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00637
name: glycochenodeoxycholate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
constant: false
boundary condition: false
is: CHEBI:36252

metaM dmnoncoa x
name: 4,8 dimethylnonanoyl-CoA
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB11604
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110054#_89e43480_d6b0_4bcb_8a81_fa0519e4bc0f
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3635
initial concentration: NaN
constant: false
name: INPP5D
is: Q92835
boundary condition: true
initial amount: NaN

metaR NCKt
name: Na+/Ca2+-K+ exchange
product: MODEL1310110054#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
fast: false
reactant: MODEL1310110054#
modifier: MODEL1310110054#
is described by: ECO:0000269
kinetic law: MODEL1310110054#

metaR NACASPtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11279290 NOTES:MM
reactant: MODEL1310110054#
product: MODEL1310110054#
reversible: false
fast: false
is: SBO:0000185
kinetic law: MODEL1310110054#
type: Reaction
name: N-acetyl-L-aspartate transport (mitochondria to cytosol)
is described by: ECO:0000000

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaR r0715
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reversible: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/6.3.2.5
modifier: MODEL1310110054#
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_5e30126a_3b65_4893_8485_dddf12756544
has only substance units: false
initial concentration: NaN
name: PLCB1
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is: Q9NQ66
is encoded by: hsa:23236

metaM man l
name: D-mannose
is: HMDB00169
is: CHEBI:16024
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_e976da6f_8e8d_4cbe_b02a_24e0b5dad643
boundary condition: true
is encoded by: hsa:2182
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q5JWV8
has only substance units: false
name: ACSL4

metaR r1384
type: Reaction
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
reversible: true
name: Guanosine aminohydrolase EC:3.5.4.15
product: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_af730452_9513_456d_825f_af6f3b331aaa
is encoded by: hsa:NM 013421
name: _NM_013421_1_e
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_9ebb7004_da7c_4562_8a63_da9082e29da4
is encoded by: hsa:51604
is: SBO:0000252
type: Species
has only substance units: false
name: PIGT
is: Q969N2
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_aac1f7a7_685f_4a98_8e12_fa284f7af207
boundary condition: true
is encoded by: hsa:6392
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
name: SDHD
is: O14521
has only substance units: false

metaM 3mob e
initial concentration: 1.0
is: CHEBI:11851
is: SBO:0000247
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
is: HMDB00019
type: Species
name: 3-methyl-2-oxobutanoate
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_41823792_e7d1_461a_83d4_1e13d8226627
has only substance units: false
initial amount: NaN
name: HADH
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3033
is: Q16836

http://identifiers.org/biomodels.db/MODEL1310110054#_d71058e5_4354_4df0_afa5_a57045935c1f
initial amount: NaN
name: PDE8A
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:5151

metaM ksii core2 deg8 l
is: CHEBI:12936
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 8
is: HMDB00143
constant: false
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C36H60N3O25X CHARGE: 0

metaM bildglcur e
has only substance units: false
is: CHEBI:58471
initial concentration: 1.0
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
name: bis(beta-glucosyluronate)bilirubin
constant: false
boundary condition: false
type: Species
is: HMDB03325
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_1df88381_5a4b_4eb4_88d6_9896c39827a8
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: ACOX1
boundary condition: true
is encoded by: hsa:51
type: Species
constant: false
is: Q15067

metaR r0716
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
reversible: false
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
product: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_00fa2bba_0ac7_437b_b5d8_001a9a862ce0
is encoded by: hsa:124454
is: SBO:0000252
boundary condition: true
is: Q5JPH6
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: EARS2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_9b8e8ce2_2b50_4cef_9732_3d16a8ed1020
boundary condition: true
has only substance units: false
is encoded by: hsa:2629
name: GBA
initial amount: NaN
type: Species
constant: false
is: B7Z6S1
initial concentration: NaN
is: SBO:0000252

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaR LNLCCPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#
reversible: false
is: SBO:0000176
name: carnitine transferase
type: Reaction
reactant: MODEL1310110054#

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaR DMATTx
product: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
is: SBO:0000176
reactant: MODEL1310110054#
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.5.1.1
name: dimethylallyltranstransferase
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
fast: false
reversible: false

metaR S6TASE8ly
modifier: MODEL1310110054#
is described by: ECO:0000000
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
name: N-acetylgalactosamine-6-sulfatase, lysosomal
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction

metaR S6TASE14ly
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110054#
modifier: MODEL1310110054#
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_5a1a0b6c_dc9e_4058_ab1b_a1866bd9d4e4
boundary condition: true
is encoded by: hsa:3992
name: FADS1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: O60427
type: Species

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_b588d3a1_a2dc_47cc_a17a_769efb880e31
initial amount: NaN
is: E9KL44
boundary condition: true
name: HADHA
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3030

metaR VALtec
reversible: true
product: MODEL1310110054#
modifier: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
name: L-valine transport via diffusion (extracellular to cytosol)
is: SBO:0000185
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
kinetic law: MODEL1310110054#
is described by: ECO:0000269
fast: false

metaR RDH4
product: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
name: retinol dehydrogenase (13-cis,NADH)
reversible: true
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:9115228 NOTES:IT
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.1.1.315

metaR PACCOAL
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110054#
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
reversible: false
name: phenylacetate-CoA ligase

metaM 3decdicoa x
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
name: 3,7-decadienoylcoa
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false

metaM prostgd2 c
name: prostaglandin D2(1-)
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB01403
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: CHEBI:57406

metaM phyt2ohcoa x
initial amount: NaN
is: HMDB01295
is: CHEBI:57334
name: 2-hydroxyphytanoyl-CoA(4-)
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)32(50)40(54)70-20-19-43-30(49)17-18-44-38(53)35(52)41(6,7)22-63-69(60,61)66-68(58,59)62-21-29-34(65-67(55,56)57)33(51)39(64-29)48-24-47-31-36(42)45-23-46-37(31)48/h23-29,32-35,39,50-52H,8-22H2,1-7H3,(H,43,49)(H,44,53)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/t26?,27?,28?,29-,32?,33-,34-,35+,39-/m1/s1 EHMN_ABBREVIATION: C07343
type: Species

metaM dsmsterol r
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
is: SBO:0000247
type: Species
name: desmosterol
has only substance units: false
initial amount: NaN
constant: false
is: HMDB02719
is: CHEBI:17737

metaM dttp e
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01342
type: Species
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: CHEBI:37568
is: SBO:0000247
name: dTTP(4-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_eeb57b36_2c01_4461_9ce9_2f1f884f9014
is: SBO:0000252
name: ADCY8
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:114
initial amount: NaN
is: Q4F7X0
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_07e41303_2ef5_43e8_b0e2_3a59d906c562
constant: false
initial amount: NaN
name: SLC33A1
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:9197
is: O00400
is: SBO:0000252

metaR CYTK12n
product: MODEL1310110054#
type: Reaction
fast: false
modifier: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110054#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
name: cytidylate kinase (dCMP,dCTP),nuclear

http://identifiers.org/biomodels.db/MODEL1310110054#_e3272e30_1752_49fb_a575_009e0232b490
initial amount: NaN
has only substance units: false
name: COX1
type: Species
constant: false
is encoded by: hsa:4512
boundary condition: true
is: Q7GXY8
initial concentration: NaN
is: SBO:0000252

metaM bildglcur c
initial amount: NaN
is: HMDB03325
constant: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
boundary condition: false
is: CHEBI:58471
name: bis(beta-glucosyluronate)bilirubin
initial concentration: 1.0

metaM pyr x
is: CHEBI:15361
initial concentration: 1.0
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: HMDB00243
name: pyruvate
initial amount: NaN
type: Species
is: SBO:0000247
is: C00022
boundary condition: false
is: http://identifiers.org/pubchem.compound/3324
has only substance units: false
constant: false

metaR RDH2
fast: false
reactant: MODEL1310110054#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110054#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.315
product: MODEL1310110054#
name: retinol dehydrogenase (9-cis,NADH)
kinetic law: MODEL1310110054#

metaM hs deg16 l
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
initial concentration: 1.0
has only substance units: false
name: heparan sulfate, degradation product 16
constant: false
type: Species
is: CHEBI:21338
is: HMDB02704
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_680455e2_1010_45dc_987f_d1795eff05cc
type: Species
name: PKLR
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5313
is: SBO:0000252

metaM h2o g
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:15377
constant: false
initial amount: NaN
is: HMDB02111
name: water
is: SBO:0000247
type: Species
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

metaR UMPKn
name: UMP kinase, nuclear
kinetic law: MODEL1310110054#
is described by: ECO:0000269
modifier: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
type: Reaction
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_6a43580b_0685_43e1_97ec_a3a83db2e5ab
initial concentration: NaN
is encoded by: hsa:766
is: SBO:0000252
is: Q86YU0
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: CA7
boundary condition: true

metaM 2oxoadp c
is: HMDB00225
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: CHEBI:57499
name: 2-oxoadipate(2-)
initial concentration: 1.0

metaR 3MOBte
is described by: ECO:0000134
name: Transport of 3-methyl-2-oxobutanoate
is: SBO:0000185
kinetic law: MODEL1310110054#
reversible: true
fast: false
product: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110054#_492d4ddf_7703_4a8e_b9e2_f4127def2a63
constant: false
is: SBO:0000252
name: PDE2A
is encoded by: hsa:5138
initial concentration: NaN
type: Species
has only substance units: false
is: Q8IW54
initial amount: NaN
boundary condition: true

metaM CE2432 m
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
is: CHEBI:57795
is: SBO:0000247
constant: false
initial amount: NaN
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
has only substance units: false

metaR RDH1
product: MODEL1310110054#
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.315
reversible: true
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
name: retinol dehydrogenase (all-trans)
reactant: MODEL1310110054#
is described by: ECO:0000269

metaM idour l
name: L-iduronate
is: HMDB02704
type: Species
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:21338

metaM nm4masn g
has only substance units: false
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
constant: false
is: C05882
is: SBO:0000247
boundary condition: false
notes: FORMULA: C54H90N3O40X CHARGE: 0
type: Species
initial amount: NaN
initial concentration: 1.0

metaR RE0565C
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
product: MODEL1310110054#
is: SBO:0000176
reactant: MODEL1310110054#
name: RE0565
reversible: false
fast: false
kinetic law: MODEL1310110054#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_03bac3e5_2865_465e_b26d_c5996b23a5dc
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
name: NME7
is: Q9Y5B8
is encoded by: hsa:29922
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_32d69265_a48c_45dc_84e9_13170c8e2222
initial amount: NaN
is: P00813
name: ADA
is encoded by: hsa:100
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
type: Species

metaM naglc2p L c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C1160H1898N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
has only substance units: false
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human liver homolog
type: Species
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:18278

metaR r0156
reactant: MODEL1310110054#
is described by: ECO:0000000
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
type: Reaction
modifier: MODEL1310110054#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.40
product: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110054#_ef2dc1d3_fb76_42d9_9616_3f55c25ed2b5
initial amount: NaN
is encoded by: hsa:9791
has only substance units: false
type: Species
is: P48651
name: PTDSS1
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM man r
constant: false
initial amount: NaN
type: Species
is: CHEBI:16024
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: D-mannose
is: HMDB00169
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
boundary condition: false

metaM dttp c
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:37568
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: HMDB01342
constant: false
name: dTTP
is: C00459

metaM ksi deg24 l
initial amount: NaN
is: SBO:0000247
is: HMDB00143
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: keratan sulfate I, degradation product 24
is: CHEBI:12936
constant: false
type: Species

metaM c4crn x
type: Species
notes: FORMULA: C11H21NO4 CHARGE: 0
has only substance units: false
name: butyryl carnitine
is: HMDB02013
is: C02862
initial amount: NaN
is: http://identifiers.org/pubchem.compound/213144
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR DOLPMT3 Ler
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.1.260
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
type: Reaction
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000176
reversible: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
is described by: ECO:0000000

metaR BHBtm
reactant: MODEL1310110054#
is: SBO:0000185
kinetic law: MODEL1310110054#
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
reversible: true
product: MODEL1310110054#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
type: Reaction

metaR CLOXAtex2
fast: false
kinetic law: MODEL1310110054#
is: SBO:0000185
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is described by: ECO:0000304
reversible: false
reactant: MODEL1310110054#
name: chloride transport via oxalate countertransport (2:1)
type: Reaction
modifier: MODEL1310110054#

metaM dece3coa x
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
name: 3-decenoylcoa
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4

metaM h2o e
initial concentration: 1.0
is: CHEBI:15377
constant: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
is: HMDB02111
type: Species
is: SBO:0000247
boundary condition: false
name: H2O
initial amount: NaN
is: C00001

http://identifiers.org/biomodels.db/MODEL1310110054#_0030c553_4af5_4bac_beb5_2853eeeba515
name: PIP5K1C
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:23396
is: O60331
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_26fb1579_fe2b_466f_8ac1_24518238a430
initial concentration: NaN
name: NDUFA3
has only substance units: false
is: O95167
is: SBO:0000252
type: Species
is encoded by: hsa:4696
initial amount: NaN
boundary condition: true
constant: false

metaR r0732
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000176
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction
reactant: MODEL1310110054#
product: MODEL1310110054#

metaR r0885
modifier: MODEL1310110054#
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.38
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7

metaR UAGDP
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
product: MODEL1310110054#
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000176
fast: false
reversible: false
name: UDP-N-acetylglucosamine diphosphorylase
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.7.23

http://identifiers.org/biomodels.db/MODEL1310110054#_5bb36f6b_79c5_47e4_92ea_58b96abb5f5e
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6487
constant: false
is: Q96L53
name: ST3GAL3
has only substance units: false

metaR AHEXASE2ly
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
fast: false
reversible: false
kinetic law: MODEL1310110054#
is described by: ECO:0000000
reactant: MODEL1310110054#
is: SBO:0000176

metaM pchol hs r
name: Phosphatidylcholine
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
is: SBO:0000247
constant: false
is: CHEBI:16110

http://identifiers.org/biomodels.db/MODEL1310110054#_e1b76a3d_fd33_4c91_b9ff_73352375667f
initial concentration: NaN
has only substance units: false
constant: false
name: PANK2
is: Q9BZ23
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:80025
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_a36627ea_cb18_4d68_8041_fa7bfe806b09
is: SBO:0000252
is: P49753
name: ACOT2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10965
constant: false
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_73f29197_b3da_4017_b2bc_5430c0b5214a
has part: P00326
initial concentration: NaN
has only substance units: false
is: SBO:0000297
boundary condition: true
type: Species
initial amount: NaN
name: ADH1B:ADH1C
constant: false
is encoded by: hsa:126

metaR LYStip
is: SBO:0000185
type: Reaction
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
fast: false
reversible: false
name: L-lysine transport, peroxisomal (irreversible)

metaR r0731
reversible: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
fast: false
product: MODEL1310110054#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110054#

metaR FALDH
reversible: true
is: SBO:0000176
is described by: ECO:0000269
fast: false
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.1.1.1
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
type: Reaction
name: formaldehyde dehydrogenase
modifier: MODEL1310110054#
product: MODEL1310110054#

metaR G6PDH2c
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.49
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (2539.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:found in rats. HMP shunt reactions are cytosolic. Irreversible reaction, coefficient changed to 3
is: SBO:0000176
kinetic law: MODEL1310110054#
fast: false
is described by: ECO:0000134
type: Reaction
product: MODEL1310110054#
name: glucose 6-phosphate dehydrogenase
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_a2ec00be_bffc_4207_99e4_e6a0f272b359
name: NDUFA3
initial amount: NaN
is encoded by: hsa:4696
is: SBO:0000252
is: O95167
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
constant: false

metaM hspg l
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
type: Species
initial concentration: 1.0
name: heparan sulfate proteoglycan
is: CHEBI:17899
is: HMDB01993
constant: false

metaR FAS140COA
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
name: fatty-acyl-CoA synthase (n-C14:0CoA)
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110054#
reversible: false
modifier: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR COAtm
product: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
fast: false
name: CoA transporter
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
is described by: ECO:0000269

metaR r2389
reactant: MODEL1310110054#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
modifier: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
type: Reaction
fast: false
reversible: false

metaR PGDI
reactant: MODEL1310110054#
is described by: ECO:0000269
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.5.1.18
is version of: http://identifiers.org/ec-code/5.3.99.2
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
modifier: MODEL1310110054#
is: SBO:0000176
reversible: true
type: Reaction
kinetic law: MODEL1310110054#
fast: false
name: Prostaglandin-H2 D-isomerase [Precursor]

metaM crm hs r
is: SBO:0000247
name: N-acylsphingosine
type: Species
is: CHEBI:52639
has only substance units: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN

metaR r2388
is: SBO:0000185
product: MODEL1310110054#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
is described by: ECO:0000000
reactant: MODEL1310110054#
reversible: false
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110054#
type: Reaction

metaR r0734
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110054#
reversible: false
kinetic law: MODEL1310110054#
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_8cf38007_bf8f_49a2_ad94_c3a564c1bf9d
is encoded by: hsa:10005
has only substance units: false
constant: false
type: Species
name: ACOT8
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: O14734

metaM glu L e
has only substance units: false
is: CHEBI:29985
boundary condition: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
is: HMDB00148
name: L-glutamate(1-)

metaM 2mp2coa m
initial concentration: 1.0
has only substance units: false
is: CHEBI:27754
initial amount: NaN
constant: false
name: 2-Methylprop-2-enoyl-CoA
type: Species
boundary condition: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
is: HMDB01011
is: SBO:0000247

metaM 44mzym r
has only substance units: false
initial concentration: 1.0
type: Species
name: 14-demethyllanosterol
boundary condition: false
is: HMDB01286
is: SBO:0000247
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
initial amount: NaN
constant: false
is: CHEBI:18364

metaM CE2424 m
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
is: HMDB11123
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28387

http://identifiers.org/biomodels.db/MODEL1310110054#_b22b653d_f307_4518_9f13_3b603c574c24
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI640625
name: _AI640625_1_c
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_e8709ff9_f3db_4a80_a64e_f6c5b1ed5284
boundary condition: true
is: Q9NY65
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
name: EHHADH
is encoded by: hsa:1962
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_def300d6_87e3_4138_9ca7_00cf8b8933cb
name: SLC26A1
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:10861
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM hs deg9 l
type: Species
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
initial amount: NaN
has only substance units: false
is: CHEBI:17115
constant: false
name: heparan sulfate, degradation product 9
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00187

http://identifiers.org/biomodels.db/MODEL1310110054#_2a62467c_af8e_4dec_90e4_52822c7ad5c2
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: NDUFA11
constant: false
is: C9JT23
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:126328

metaM ksii core2 pre7 g
has only substance units: false
initial concentration: 1.0
constant: false
is: C00130
initial amount: NaN
notes: FORMULA: C67H108N5O51SX CHARGE: -2
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 7
is: SBO:0000247
is: CHEBI:58053
boundary condition: false
type: Species

metaM pa hs c
has only substance units: false
is: CHEBI:57739
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
name: phosphatidate(2-)
type: Species
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
boundary condition: false

metaR r2387
type: Reaction
fast: false
reactant: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110054#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
product: MODEL1310110054#
modifier: MODEL1310110054#

metaR r0733
product: MODEL1310110054#
is described by: ECO:0000000
modifier: MODEL1310110054#
is: SBO:0000176
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.12
reversible: false
fast: false
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#

metaR RE2996X
fast: false
reactant: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110054#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.34
kinetic law: MODEL1310110054#
name: RE2996
modifier: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26063.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110054#_0e15a6f9_ac35_409c_9a76_3074a1386a58
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is: Q8N1Q1
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: CA13
is encoded by: hsa:377677

metaR RE1532M
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
type: Reaction
name: RE1532
modifier: MODEL1310110054#
reversible: true

metaR r1538
product: MODEL1310110054#
modifier: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
reactant: MODEL1310110054#
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
is: SBO:0000185
kinetic law: MODEL1310110054#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction

metaR NACHEX15ly
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110054#
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110054#

metaM thm c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:0
name: Thiamin
type: Species
is: SBO:0000247
notes: FORMULA: C12H17N4OS CHARGE: 1
is: C00378
is: HMDB00235

metaR ACACT1r
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
name: acetyl-CoA C-acetyltransferase
reversible: true
type: Reaction
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000000
modifier: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1

metaM glu L c
is: HMDB00148
type: Species
initial concentration: 1.0
is: CHEBI:29985
is: SBO:0000247
initial amount: NaN
constant: false
name: L-glutamate(1-)
boundary condition: false
has only substance units: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025

metaR PRISTANALtx
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
reversible: true
is: SBO:0000185
name: pristanal peroxisomal transport

metaR FAOXC16DCC14DCx
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16DC-->C14DC)x
type: Reaction

metaR UPPN
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
kinetic law: MODEL1310110054#
is: SBO:0000176
name: b-ureidopropionase
product: MODEL1310110054#
reversible: false
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.5.1.6
is described by: ECO:0000269
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_5d7e4d72_035b_431d_ac64_e803167b1984
has only substance units: false
name: SLC26A6
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:65010
initial amount: NaN
is: SBO:0000252
constant: false
is: Q9Y3Y1

metaR r0881
fast: false
product: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
name: Active transport
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction

metaM thyox L e
is: SBO:0000247
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: HMDB00248
name: L-thyroxine
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:18332
initial concentration: 1.0

metaM 5adtststerone c
constant: false
initial amount: NaN
is: CHEBI:16330
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
type: Species
is: HMDB02961
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: 17beta-hydroxy-5alpha-androstan-3-one
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_a1f0b3d0_1a84_4be3_ac3d_faa5b8aa0d3f
is encoded by: hsa:50484
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: Q7LG56
is: SBO:0000252
name: RRM2B

metaM ksi pre30 g
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00175
initial amount: NaN
constant: false
name: keratan sulfate I biosynthesis, precursor 30
type: Species
is: SBO:0000247
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
is: C00130
is: CHEBI:58053

metaR COAtp
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110054#
is described by: ECO:0000000
reactant: MODEL1310110054#
name: coenzyme A transport, peroxisomal
is: SBO:0000185
product: MODEL1310110054#
type: Reaction

metaR ADK1m
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
product: MODEL1310110054#
reversible: true
name: adenylate kinase, mitochondrial
is: SBO:0000176
kinetic law: MODEL1310110054#
fast: false
modifier: MODEL1310110054#
reactant: MODEL1310110054#

metaR RE3381E
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290,PMID:10690708,PMID:11087858,PMID:11818531 NOTES:
name: RE3381
is version of: http://identifiers.org/ec-code/3.2.1.31
product: MODEL1310110054#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
type: Reaction
is: SBO:0000176
fast: false

metaM dectricoa x
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
name: 2,4,7-decatrienoylcoa
is: http://identifiers.org/pubchem.compound/16019966
type: Species

metaR ACACT1x
reactant: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.3.1.9
product: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
is described by: ECO:0000134
modifier: MODEL1310110054#
type: Reaction
is: SBO:0000176
name: acetyl-CoA C-acetyltransferase, mitochondrial

metaR RE3012R
type: Reaction
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (224.1) or (218.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9799565,PMID:9862787 NOTES:
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000176
fast: false
name: RE3012
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110054#

metaR r0735
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110054#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110054#
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction
reactant: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_c0f48d3b_35cc_4c91_ae41_024084b179f2
is: A8K3J4
name: CA14
is encoded by: hsa:23632
boundary condition: true
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_ff4acd7d_9821_4773_9663_3dc516c13508
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
name: _AA977580_1_c
boundary condition: true
is encoded by: hsa:AA977580
constant: false
is: SBO:0000252

metaR DDCRNe
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydodecanoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_8ab27bc0_e629_486e_a2b7_c3ff6da89975
initial amount: NaN
type: Species
is encoded by: hsa:83530
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: _83530_1_c

metaR PCHOLPm hs
is version of: http://identifiers.org/ec-code/3.1.4.4
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
fast: false
product: MODEL1310110054#
is described by: ECO:0000269
reactant: MODEL1310110054#
reversible: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
name: choline phosphatase

metaR ACACT10m
fast: false
is described by: ECO:0000134
reactant: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
name: acetyl-CoA C-acetyltransferase, mitochondrial
modifier: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.3.1.9
kinetic law: MODEL1310110054#
reversible: true
type: Reaction

metaR DOLPH Ler
type: Reaction
reversible: false
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
product: MODEL1310110054#
name: Dolichol-phosphate phosphohydrolase, human (liver)
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
is described by: ECO:0000000

metaR RE3243R
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110054#
name: RE3243
reactant: MODEL1310110054#
is: SBO:0000176
product: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
is described by: ECO:0000000

metaR SGALSIDEtl
kinetic law: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reactant: MODEL1310110054#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: sgalside hs intracellular transport

metaR BUTt2r
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
product: MODEL1310110054#
is described by: ECO:0000269
type: Reaction
name: Butyrate transport via proton symport, reversible

metaR MELATNOX
reactant: MODEL1310110054#
modifier: MODEL1310110054#
name: Melatonin:NADP oxidoreductase
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (1557.1) or (1543.1) or (1545.1) or (1544.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15616152 NOTES:SAB made up name
is version of: http://identifiers.org/ec-code/1.14.13.48
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.14.1
product: MODEL1310110054#

metaR HDCEAtr
name: fatty acid transport via diffusion
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
product: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000185

metaM ksi deg7 l
is: SBO:0000247
notes: FORMULA: C210H337N15O181S10 CHARGE: -10
is: CHEBI:16953
constant: false
name: keratan sulfate I, degradation product 7
initial amount: NaN
initial concentration: 1.0
is: HMDB00812
type: Species
has only substance units: false
boundary condition: false

metaM 12ppd R c
name: (R)-propane-1,2-diol
is: CHEBI:28972
constant: false
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01881
initial amount: NaN
has only substance units: false

metaM thyox L c
constant: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: CHEBI:18332
is: HMDB00248
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
name: L-thyroxine
boundary condition: false

metaM 5adtststerone e
is: HMDB02961
has only substance units: false
name: 17beta-hydroxy-5alpha-androstan-3-one
is: CHEBI:16330
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_e647d85d_b436_46b6_b0f0_293c8a85b129
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2271
initial concentration: NaN
type: Species
is: P07954
boundary condition: true
name: FH
constant: false
has only substance units: false

metaR ALACYSNaEx
product: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110054#
type: Reaction
fast: false
modifier: MODEL1310110054#
is described by: ECO:0000269
reactant: MODEL1310110054#
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110054#_81403972_d7a9_43fb_8810_b619622fcb24
has part: B7Z3U6
has only substance units: false
is: SBO:0000297
name: ATP1A1:ATP1B3
type: Species
is encoded by: hsa:476
has part: P54709
initial amount: NaN
boundary condition: true
is encoded by: hsa:483
initial concentration: NaN
constant: false

metaR SERDGLNexR
name: D-Serine/Glutamine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110054#
reversible: true
product: MODEL1310110054#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110054#
is described by: ECO:0000304
reactant: MODEL1310110054#

metaR COAtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110054#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110054#
fast: false
is: SBO:0000185
name: coenzyme A transport, nuclear
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_f33f643c_b119_4364_bee5_90b3d5a238a3
is: Q9NYR8
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:50700
boundary condition: true
name: RDH8

metaR UREAt
reactant: MODEL1310110054#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (6523.1) or (6563.1) or (6528.1) or (8170.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:12856182,PMID:2490366,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:JLR
fast: false
is: SBO:0000185
type: Reaction
name: Urea transport via facilitate diffusion
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
product: MODEL1310110054#

metaM 3mop c
initial amount: NaN
is: HMDB00491
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
constant: false
is: CHEBI:28654
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671

metaR ACGALtlg
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism - may be vesicular NJ
kinetic law: MODEL1310110054#
fast: false
product: MODEL1310110054#
is described by: ECO:0000000
reactant: MODEL1310110054#
name: N-acetyl-galactosamine intracellular transport
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_79bcd228_0583_4af0_9b6d_e132a1c03798
is encoded by: hsa:AI990637
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: _AI990637_1_x
initial concentration: NaN
type: Species
constant: false

metaR KSItly
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110054#
name: keratan sulfate I transport, extracellular to lysosome
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_041f99e1_7932_48c2_9581_da910d6f53e5
initial concentration: NaN
is encoded by: hsa:1103
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
name: CHAT
type: Species
initial amount: NaN
is: Q6LEN5

metaR ASPTA
modifier: MODEL1310110054#
name: aspartate transaminase
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.1
reversible: true
reactant: MODEL1310110054#
product: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false

metaM crm hs l
is: CHEBI:52639
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
name: N-acylsphingosine
constant: false
is: SBO:0000247

metaM fmn c
constant: false
initial concentration: 1.0
initial amount: NaN
name: FMN
is: CHEBI:58210
type: Species
is: SBO:0000247
is: HMDB01520
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
is: C00061
boundary condition: false
has only substance units: false

metaM 4mzym int1 r
is: SBO:0000247
constant: false
name: 4-Methylzymosterol intermediate 1
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
boundary condition: false
initial amount: NaN
is: HMDB06927

http://identifiers.org/biomodels.db/MODEL1310110054#_7e591a0f_6953_4759_b417_21d0f3b304a9
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaM mi14p n
type: Species
is: HMDB00968
has only substance units: false
is: SBO:0000247
is: CHEBI:58282
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaM hspg e
has only substance units: false
is: CHEBI:15699
boundary condition: false
type: Species
name: heparan sulfate proteoglycan
is: HMDB00719
is: SBO:0000247
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
initial amount: NaN
initial concentration: 1.0
constant: false

metaM mpdol U c
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C1245H2040N20O220P20 CHARGE: -20
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
is: CHEBI:18396
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_578b55e5_0110_4b65_a9f6_1c7257461474
constant: false
is encoded by: hsa:6543
name: SLC8A2
type: Species
is: SBO:0000252
initial amount: NaN
is: Q9UPR5
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR GCALDD
is version of: http://identifiers.org/ec-code/1.2.1.36
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
product: MODEL1310110054#
name: Glycolaldehyde dehydrogenase
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
reactant: MODEL1310110054#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110054#_37c49ad5_f6d5_4fa8_8b08_1729b97c3208
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3612
has only substance units: false
name: IMPA1
type: Species
is: B7Z6Q4

metaM dadp c
name: dADP
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57667
initial amount: NaN
is: C00206
is: HMDB01508
has only substance units: false
initial concentration: 1.0
type: Species

metaM crvnc c
notes: FORMULA: C22H31O2 CHARGE: -1
name: cervonic acid, C22:6 n-3
is: CHEBI:36005
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB02183
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false

metaM CE4791 x
name: 3(S)-hydroxy-dihomo-gama-linolenoyl-CoA
constant: false
is: CHEBI:57923
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C41H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C41H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29(49)24-32(51)70-23-22-43-31(50)20-21-44-39(54)36(53)41(2,3)26-63-69(60,61)66-68(58,59)62-25-30-35(65-67(55,56)57)34(52)40(64-30)48-28-47-33-37(42)45-27-46-38(33)48/h8-9,11-12,14-15,27-30,34-36,40,49,52-53H,4-7,10,13,16-26H2,1-3H3,(H,43,50)(H,44,54)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/b9-8-,12-11-,15-14-/t29-,30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4791
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_e0832d85_6041_4fb1_8d57_24a6d42c89bc
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:55967
is: SBO:0000252
initial amount: NaN
constant: false
is: F8VQS7
name: NDUFA12

http://identifiers.org/biomodels.db/MODEL1310110054#_10886658_dcce_4c66_9ffd_1bc705d2725f
has only substance units: false
constant: false
is encoded by: hsa:80270
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9H2F3
boundary condition: true
initial concentration: NaN
name: HSD3B7

http://identifiers.org/biomodels.db/MODEL1310110054#_28b19dc4_2032_423d_98c7_f5f04dbc491d
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:54965
is: Q8TBF5
type: Species
name: PIGX

http://identifiers.org/biomodels.db/MODEL1310110054#_c2ea853a_ffe3_4539_b5c5_00fb2841742e
name: DGKZ
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:8525
is: G3V0F6
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR BTNt2
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110054#
reversible: true
type: Reaction
name: Biotin reversible transport via proton symport

metaM HC02149 m
is: CHEBI:28867
initial concentration: 1.0
type: Species
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: SBO:0000247
name: O-Propanoylcarnitine
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_cb9a9900_46c1_470f_9505_79bc8763adeb
is encoded by: hsa:4952
constant: false
name: OCRL
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM gacpail hs r
type: Species
is: CHEBI:57955
constant: false
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
is: C01236
initial amount: NaN
is: HMDB01127
boundary condition: false
has only substance units: false
name: glucosaminyl-acylphosphatidylinositol

metaM urate e
initial amount: NaN
name: Urate
is: CHEBI:17775
is: HMDB00289
is: C00366
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
has only substance units: false
constant: false

metaR PROt2r
kinetic law: MODEL1310110054#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110054#
reactant: MODEL1310110054#
name: L-proline reversible transport via proton symport
product: MODEL1310110054#

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_c8b21697_7ea0_41cd_999e_145bd94b73ed
is: SBO:0000297
has only substance units: false
is encoded by: hsa:522
constant: false
initial amount: NaN
is encoded by: hsa:518
initial concentration: NaN
boundary condition: true
has part: P24539
has part: O75947
is encoded by: hsa:515
is encoded by: hsa:10476
has part: P18859
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_42aa670e_0902_43b0_893b_bbaacc9a3741
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:8818
is: O94777
is: SBO:0000252
has only substance units: false
name: DPM2
boundary condition: true
initial amount: NaN

metaM crvnc e
boundary condition: false
notes: FORMULA: C22H31O2 CHARGE: -1
is: CHEBI:36005
constant: false
has only substance units: false
is: HMDB02183
name: cervonic acid, C22:6 n-3
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR FAOXC6DCC4DCx
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6DC-->C4DC)x
type: Reaction

metaR DOCO13ECOAtxc
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 13-docosenoylcoa into peroxisomes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_5acf0b0b_c449_4691_b2e1_42f5976f46e1
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
name: CYP1A1
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:1543
is: A0N0X8

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaM HC00591 m
boundary condition: false
is: SBO:0000247
name: 2-oxoglutaramate
initial amount: NaN
type: Species
has only substance units: false
constant: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
is: CHEBI:16769
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_80e1a671_4fff_408f_84b8_a1a6d6030092
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is: Q9BQG2
type: Species
boundary condition: true
name: NUDT12
has only substance units: false
is encoded by: hsa:83594

metaR NaKt
is: SBO:0000185
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
product: MODEL1310110054#
reversible: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.3.9
reactant: MODEL1310110054#
fast: false
name: Na+/K+ exchanging ATPase
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_metaM_galacgalfucgalacglcgal14acglcgalgluside_hs_g
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C78H135N4O46FULLRCO CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:26174
boundary condition: false
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_0fe9f2ef_9535_4b27_977c_9598468a85b5
boundary condition: true
is encoded by: hsa:5277
type: Species
initial amount: NaN
initial concentration: NaN
name: PIGA
has only substance units: false
is: SBO:0000252
constant: false

metaR S6T8g
reversible: false
modifier: MODEL1310110054#
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
reactant: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110054#
product: MODEL1310110054#
fast: false

metaM pchol hs m
boundary condition: false
is: CHEBI:16110
constant: false
has only substance units: false
name: Phosphatidylcholine
type: Species
is: SBO:0000247
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
initial concentration: 1.0
initial amount: NaN

metaM urate c
name: Urate
constant: false
initial amount: NaN
is: CHEBI:17775
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00289
is: C00366
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366

metaR NDPK9n
is described by: ECO:0000269
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
product: MODEL1310110054#
fast: false
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
reactant: MODEL1310110054#

metaR ORNt3m
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
fast: false
modifier: MODEL1310110054#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110054#
name: ornithine mitochondrial transport via proton antiport
reversible: true
type: Reaction
product: MODEL1310110054#
kinetic law: MODEL1310110054#

metaR S4TASE2ly
is version of: http://identifiers.org/ec-code/3.1.6.12
product: MODEL1310110054#
reversible: true
fast: false
name: N-acetylgalactosamine-4-sulfatase, lysosomal
kinetic law: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110054#
reactant: MODEL1310110054#

metaR FACOAL80i
reversible: false
reactant: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
fast: false
modifier: MODEL1310110054#
type: Reaction
name: fatty-acid--CoA ligase (octanoate)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110054#_eebb1e98_f70b_4530_b867_ee58b23feccc
name: SLC34A2
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10568
has only substance units: false
is: O95436
type: Species
initial amount: NaN
constant: false

metaR ARAB Lt
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
name: L-arabinoase extracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
fast: false

metaM trdrd m
name: Reduced thioredoxin
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: CHEBI:15967
is: SBO:0000247

metaR STS1
reactant: MODEL1310110054#
name: Steryl-sulfatase
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.2
product: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_231644de_6c47_4ba9_8f07_1348cf3e2396
name: LCT
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:3938
type: Species
is: P09848
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_eabf4bba_6a89_4fa6_9217_371959d2514d
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:216
has only substance units: false
name: ALDH1A1
is: P00352
type: Species
constant: false

metaR RE1447N
is: SBO:0000176
kinetic law: MODEL1310110054#
name: RE1447
type: Reaction
fast: false
product: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
reversible: true
is described by: ECO:0000000

metaR ACACt2m
reversible: true
type: Reaction
name: Acetoacetate mitochondrial transport via H+ symport
is: SBO:0000185
product: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
reactant: MODEL1310110054#
modifier: MODEL1310110054#

metaM dolmanp L r
initial amount: NaN
has only substance units: false
name: Dolichyl phosphate D-mannose, human liver homolog
is: CHEBI:15809
boundary condition: false
constant: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR PRO Dtde
is described by: ECO:0000134
type: Reaction
fast: false
name: D-proline transport, extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000185
product: MODEL1310110054#
reversible: true

metaR THYOXt
reversible: true
kinetic law: MODEL1310110054#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
is: SBO:0000185
product: MODEL1310110054#
reactant: MODEL1310110054#
modifier: MODEL1310110054#
is described by: ECO:0000269
name: T4 transport via bicarbonate countertransport

metaM abt e
has only substance units: false
initial amount: NaN
is: CHEBI:18403
name: L-arabinitol
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: SBO:0000247
is: HMDB01851
type: Species
initial concentration: 1.0
constant: false

metaM 3snpyr m
has only substance units: false
initial concentration: 1.0
name: 3-Sulfinopyruvate
type: Species
is: HMDB02332
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:1665
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527

metaR GAPD
is described by: ECO:0000134
reversible: true
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
is version of: http://identifiers.org/ec-code/1.2.1.12
kinetic law: MODEL1310110054#
name: glyceraldehyde-3-phosphate dehydrogenase
reactant: MODEL1310110054#
fast: false
type: Reaction
modifier: MODEL1310110054#
is: SBO:0000176

metaR r0450
is version of: http://identifiers.org/ec-code/4.2.1.3
reversible: true
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
product: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000176
is described by: ECO:0000000
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
type: Reaction

metaR S6TASE11ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
product: MODEL1310110054#
fast: false
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction
modifier: MODEL1310110054#
reactant: MODEL1310110054#

metaR PHACCOAGLNAC
kinetic law: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
reversible: false
fast: false
product: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000176

metaR DHCR72r
fast: false
reactant: MODEL1310110054#
name: 7-dehydrocholesterol reductase
type: Reaction
is described by: ECO:0000269
product: MODEL1310110054#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.3.1.21

metaM cs b l
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
type: Species
is: CHEBI:36005
boundary condition: false
is: HMDB02183
initial concentration: 1.0
notes: FORMULA: C45H66N2O49S4 CHARGE: -6

metaR r1291
product: MODEL1310110054#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110054#
type: Reaction
fast: false
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_1f2d9845_a89f_4bc9_9db8_fc4d1b02fdb3
has only substance units: false
initial amount: NaN
is: Q9BTY2
name: FUCA2
is encoded by: hsa:2519
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_4e560828_964f_41d0_8e0b_cf858d09a0f0
type: Species
initial concentration: NaN
is: E9KL42
name: ACOT1
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:641371
constant: false
has only substance units: false

metaM HC01501 c
constant: false
notes: FORMULA: HO3S2 CHARGE: -1 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-1 EHMN_ABBREVIATION: C05529
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:33539
name: hydroxidodioxidosulfidosulfate(1-)
has only substance units: false
initial concentration: 1.0

metaM HC01407 m
initial concentration: 1.0
is: CHEBI:28276
is: SBO:0000247
boundary condition: false
name: (S)-Hydroxyhexanoyl-CoA
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
has only substance units: false
type: Species
constant: false
initial amount: NaN

metaM ppcoa c
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: SBO:0000247
is: C00100
initial concentration: 1.0
name: Propanoyl-CoA
is: HMDB01275
constant: false
is: CHEBI:57392

metaM maltttr e
initial concentration: 1.0
name: Maltotetraose
type: Species
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
has only substance units: false
is: C02052
is: HMDB01296
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5141

metaM ksi deg23 l
is: HMDB00143
is: CHEBI:12936
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
name: keratan sulfate I, degradation product 23
type: Species
is: SBO:0000247
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
initial concentration: 1.0

metaR SGALSIDEtg
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reactant: MODEL1310110054#
product: MODEL1310110054#
name: sgalside hs intracellular transport

metaM abt c
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
boundary condition: false
is: CHEBI:18403
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB01851
has only substance units: false
name: L-arabinitol
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_a5fa5a5a_596f_41eb_8d94_9516f4aa5079
type: Species
name: _AI373818_1_m
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI373818
constant: false

metaR r1428
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
reactant: MODEL1310110054#
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110054#
is described by: ECO:0000000
name: Free diffusion
fast: false
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_6c80db5e_e5bd_4581_9cf3_924c67c6393f
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:3037
name: HAS2
initial concentration: NaN
is: Q92819

http://identifiers.org/biomodels.db/MODEL1310110054#_a19aee96_2c19_4312_9edc_1946b7e9acfa
name: SLC7A8
is encoded by: hsa:23428
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is: Q86U05

http://identifiers.org/biomodels.db/MODEL1310110054#_ac401f82_071d_4e89_8a90_739a7b89b94e
initial amount: NaN
name: HAO1
is encoded by: hsa:54363
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q9UJM8
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_ee2f4f47_55b1_4c83_babc_005af3658f55
is: SBO:0000252
is encoded by: hsa:55811
initial amount: NaN
is: F5GWS5
has only substance units: false
initial concentration: NaN
constant: false
name: ADCY10
boundary condition: true
type: Species

metaR r1292
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110054#
type: Reaction
name: Postulated transport reaction

metaR r0730
fast: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000176
reversible: false
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
type: Reaction
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110054#_ebd02462_3ca1_4831_834b_83c860d734f2
boundary condition: true
name: PDE3B
has only substance units: false
type: Species
initial concentration: NaN
is: Q13370
constant: false
is encoded by: hsa:5140
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_59215e3e_234c_4273_90b3_a1ed369b966d
boundary condition: true
name: HK1
constant: false
is: SBO:0000252
is encoded by: hsa:3098
has only substance units: false
is: B3KXY9
initial amount: NaN
initial concentration: NaN
type: Species

metaR AG13T16g
kinetic law: MODEL1310110054#
is described by: ECO:0000000
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
product: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
is: SBO:0000176
modifier: MODEL1310110054#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR DM dgpi prot hs r
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dgpi prot hs(r)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_86a12dc6_deca_435a_b469_15efbc8776a3
is: SBO:0000252
constant: false
name: ADSSL1
boundary condition: true
type: Species
is: Q8N142
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:122622

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaR r1429
reversible: true
fast: false
name: Free diffusion
product: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:

metaR DNDPt29m
reversible: false
is described by: ECO:0000269
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
fast: false
name: dCDP transport via dADP antiport
type: Reaction
reactant: MODEL1310110054#
is: SBO:0000185

metaR COAtg
kinetic law: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
is described by: ECO:0000000
name: CoA transport in Golgi via diffusion
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_a3b90fd7_6150_4e7b_aaac_917d54969df4
is: SBO:0000252
type: Species
is: O75947
initial amount: NaN
has only substance units: false
name: ATP5H
initial concentration: NaN
is encoded by: hsa:10476
constant: false
boundary condition: true

metaR RE1447M
is described by: ECO:0000000
name: RE1447
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.41
product: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: true

metaM dheas c
initial concentration: 1.0
type: Species
is: CHEBI:57905
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB01032
boundary condition: false
has only substance units: false
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)

metaM 56dura c
type: Species
is: SBO:0000247
is: HMDB00076
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
has only substance units: false
constant: false
initial amount: NaN
name: 5,6-dihydrouracil
initial concentration: 1.0
boundary condition: false
is: CHEBI:15901

metaR MI1345PP
is: SBO:0000176
kinetic law: MODEL1310110054#
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
fast: false
product: MODEL1310110054#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.86
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.1.3.36
is version of: http://identifiers.org/ec-code/3.1.3.56

metaR FAOXC181C161x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C18:1-->C16:1)x
type: Reaction

metaM acgal1p c
is: SBO:0000247
is: CHEBI:55404
constant: false
boundary condition: false
is: HMDB06480
type: Species
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
initial concentration: 1.0
has only substance units: false
name: N-Acetyl-D-galactosamine 1-phosphate
initial amount: NaN

metaR H6ET3er
is: SBO:0000176
fast: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.8.1

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaM 5oxpro c
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00267
type: Species
name: 5-oxoprolinate
boundary condition: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57606

http://identifiers.org/biomodels.db/MODEL1310110054#_a3b05371_580a_482e_a4f9_49cdb4246578
initial amount: NaN
has only substance units: false
type: Species
name: PIGA
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5277
constant: false
is: P37287

metaM xol7aone m
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: CHEBI:17899
name: 7alpha-hydroxycholest-4-en-3-one
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB01993
type: Species

metaM lnlccoa c
type: Species
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
constant: false
name: linoleic coenzyme A
is: http://identifiers.org/pubchem.compound/5462164
is: HMDB01064
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN

metaR GALNTg
kinetic law: MODEL1310110054#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.1.41
modifier: MODEL1310110054#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
name: GalNAc transferase, Golgi apparatus
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_08272eb3_ab49_4d8b_8b9e_9796a23e92de
is: Q9NY65
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1962
has only substance units: false
type: Species
is: SBO:0000252
constant: false
name: EHHADH

metaM ppcoa x
name: Propanoyl-CoA
constant: false
is: HMDB01275
boundary condition: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial concentration: 1.0
type: Species
initial amount: NaN
is: C00100
is: CHEBI:57392
has only substance units: false
is: SBO:0000247

metaM c4crn e
initial concentration: 1.0
is: C02862
is: HMDB02013
initial amount: NaN
is: SBO:0000247
constant: false
name: butyryl carnitine
has only substance units: false
notes: FORMULA: C11H21NO4 CHARGE: 0
is: http://identifiers.org/pubchem.compound/213144
type: Species
boundary condition: false

metaR RTOTALFATPc
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

metaR SERtN1
type: Reaction
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
name: Serine transport (Na, H coupled)
reversible: true
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
product: MODEL1310110054#

metaR LNLNCAt
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110054#
reactant: MODEL1310110054#
name: fatty acid transport via diffusion
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction

metaM pchol hs c
initial concentration: 1.0
name: Phosphatidylcholine
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16110
type: Species
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_0becbb43_b6c4_4621_9b8f_62bdecd47319
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaR HS1ly
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.10.1.1
is described by: ECO:0000000
reactant: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
type: Reaction
fast: false
kinetic law: MODEL1310110054#
is: SBO:0000176
name: heparan-N-sulfatase, lysosomal
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_e7154f6f_c616_43f9_b823_ac1e4ded032f
initial concentration: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
name: GUCY1B2
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2974

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaR DOLPMT4 Ler
reactant: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110054#
is: SBO:0000185
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
is described by: ECO:0000000
fast: false
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110054#_d8a0f0ed_4fad_40dc_8b7e_63c0f6c0e643
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
name: PYCRL
is: Q53H96
type: Species
is encoded by: hsa:65263

metaR IDOAASE2ly
modifier: MODEL1310110054#
fast: false
is: SBO:0000176
name: alpha-L-iduronidase, lysosomal
type: Reaction
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.76
reversible: false
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110054#

metaR DOLGLCP Uter
type: Reaction
kinetic law: MODEL1310110054#
product: MODEL1310110054#
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110054#
is described by: ECO:0000000
reversible: false
fast: false

metaR OIVD3m
fast: false
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.168
reversible: false
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.2.4.4
name: 2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxopentanoate), mitochondrial
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.8.1.4

http://identifiers.org/biomodels.db/MODEL1310110054#_fdd7ce29_4980_404e_9f12_c974d7d496f3
is: Q99808
initial concentration: NaN
is encoded by: hsa:2030
type: Species
boundary condition: true
name: SLC29A1
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252

metaR CYTDtm
is: SBO:0000185
is described by: ECO:0000269
reversible: true
fast: false
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
product: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
name: cytidine facilated transport in mitochondria

metaR B3GNT31g
reversible: false
product: MODEL1310110054#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
fast: false
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaM 6pgc r
has only substance units: false
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: 6-phosphonatooxy-D-gluconate
is: HMDB01316
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:58759

metaR NMNtn
reactant: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
name: NMN transport, nuclear trhough pore
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110054#
is described by: ECO:0000000

metaR r0145
modifier: MODEL1310110054#
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110054#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.3.1
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
reactant: MODEL1310110054#
product: MODEL1310110054#
fast: false
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39

metaM c4crn c
initial concentration: 1.0
is: C02862
name: butyryl carnitine
is: HMDB02013
has only substance units: false
initial amount: NaN
notes: FORMULA: C11H21NO4 CHARGE: 0
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/213144
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_79b1b7e9_6587_452f_89c9_201881311072
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6817
boundary condition: true
constant: false
is: P50225
type: Species
name: SULT1A1
initial concentration: NaN
has only substance units: false

metaR G6PDH2r
name: glucose 6-phosphate dehydrogenase
product: MODEL1310110054#
is: SBO:0000176
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.49
reversible: true
type: Reaction
modifier: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (2539.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.49 Confidence Level: 0 AUTHORS: NOTES:JLR - a reversible reaction that is otherwise identical to ZWF

metaR r2016
is described by: ECO:0000000
modifier: MODEL1310110054#
is: SBO:0000185
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110054#
product: MODEL1310110054#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
type: Reaction
reversible: false

metaM pchol hs e
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
name: Phosphatidylcholine
constant: false
is: SBO:0000247
is: CHEBI:16110
has only substance units: false
boundary condition: false
type: Species

metaR ME1m
is version of: http://identifiers.org/ec-code/1.1.1.38
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000176
name: malic enzyme (NAD), mitochondrial
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110054#

metaR ACt2m
product: MODEL1310110054#
name: acetate mitochondrial transport via proton symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110054#
type: Reaction
fast: false
reactant: MODEL1310110054#

metaM ksi pre12 g
initial concentration: 1.0
is: C00130
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 12
is: HMDB00175
is: SBO:0000247
constant: false
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
is: CHEBI:58053

metaR r0033
reversible: false
modifier: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
type: Reaction
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.6.1.5
product: MODEL1310110054#

metaM HC01415 m
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
constant: false
initial amount: NaN
is: CHEBI:27537
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
name: (2E)-Octenoyl-CoA
initial concentration: 1.0

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_5a91f941_dd7c_48d8_bdca_9de5e5878fdc
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:5281
name: PIGF
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q6IB04

http://identifiers.org/biomodels.db/MODEL1310110054#_4a05ea90_84ad_4195_9bac_643beb857895
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:AV713053
initial amount: NaN
name: _AV713053_1_m

metaM nrpphrsf e
constant: false
boundary condition: false
is: HMDB02062
is: http://identifiers.org/pubchem.compound/123747
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
is: SBO:0000247
name: Sulfate derivative of norepinephrine

http://identifiers.org/biomodels.db/MODEL1310110054#_225ff5d9_7e77_4f36_961c_e5fdf308570b
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
name: PRDX1
is: Q06830
is encoded by: hsa:5052
has only substance units: false
initial amount: NaN
boundary condition: true

metaR RE2651R
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
name: RE2651
is: SBO:0000176

metaR FAOXC226205m
product: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
modifier: MODEL1310110054#
is: SBO:0000176
fast: false
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#

metaR HIStN1
product: MODEL1310110054#
name: Histidine transport (Na, H coupled)
modifier: MODEL1310110054#
reactant: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is: SBO:0000185
fast: false
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_2ad1024c_94af_4e52_8eaa_0059167c8586
constant: false
is: SBO:0000252
is: P57103
initial concentration: NaN
initial amount: NaN
name: SLC8A3
boundary condition: true
is encoded by: hsa:6547
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_533e90cd_641c_4940_9dff_181df904a7fb
is: P33261
boundary condition: true
initial amount: NaN
name: CYP2C19
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:1557
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_934bd83b_b4fd_43ba_b321_a1301b7c95f1
is: P14618
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
name: PKM2
is encoded by: hsa:5315
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_22ae210e_514e_4495_a3ae_a41af2d40277
has only substance units: false
initial amount: NaN
is: B7Z6S1
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:2629
constant: false
name: GBA
initial concentration: NaN

metaM e4hglu m
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: erythro-4-hydroxy-L-glutamate(1-)
constant: false
is: CHEBI:6331
is: HMDB02273
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947

metaM oagd3 hs g
initial concentration: 1.0
constant: false
is: C00029
type: Species
name: 9-O-Acetylated GD3
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
is: HMDB00286
initial amount: NaN
is: CHEBI:58367

metaM oh1 c
constant: false
has only substance units: false
is: HMDB01039
initial amount: NaN
type: Species
is: C01328
is: SBO:0000247
notes: FORMULA: HO CHARGE: -1
name: hydroxide ion
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_896a48c3_95ac_4b71_aca3_52031ff66fc7
is encoded by: hsa:3417
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
name: IDH1
is: O75874
is: SBO:0000252
boundary condition: true

metaM ump e
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
name: UMP(2-)
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57865
type: Species
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

metaR r1423
fast: false
product: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
name: Facilitated diffusion
is described by: ECO:0000000
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000185
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110054#_df4c35f4_7602_47bb_8e05_eaa16e61c139
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10246
is: O00624
constant: false
name: SLC17A2
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species

metaM orn m
notes: FORMULA: C5H13N2O2 CHARGE: 1
has only substance units: false
is: CHEBI:46912
initial amount: NaN
is: HMDB00214
is: SBO:0000247
is: C01602
type: Species
name: Ornithine
constant: false
initial concentration: 1.0
boundary condition: false

metaR AGTim
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.44
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
reactant: MODEL1310110054#
modifier: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_c212a23c_a670_48c6_9cef_20c3ea224d75
initial concentration: NaN
boundary condition: true
constant: false
name: PIGB
type: Species
is: Q92521
initial amount: NaN
is encoded by: hsa:9488
has only substance units: false
is: SBO:0000252

metaM HC00591 c
name: 2-oxoglutaramate
type: Species
constant: false
is: CHEBI:16769
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_8fa07b48_b419_4add_a510_b84454382d02
name: _BG035985_1_c
initial concentration: NaN
constant: false
is encoded by: hsa:BG035985
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false

metaM nrpphrsf c
name: Sulfate derivative of norepinephrine
boundary condition: false
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/123747
has only substance units: false
is: HMDB02062
type: Species
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_ac65a2ba_2c69_47d5_8176_2fa4ef7a4612
boundary condition: true
name: SLC2A2
is: SBO:0000252
is: P11168
initial concentration: NaN
constant: false
is encoded by: hsa:6514
type: Species
initial amount: NaN
has only substance units: false

metaR r2012
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
modifier: MODEL1310110054#
reversible: false
is: SBO:0000185
product: MODEL1310110054#
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#

metaR r0456
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
reversible: false
modifier: MODEL1310110054#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.32
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
fast: false

metaR ACt2r
name: acetate reversible transport via proton symport
reactant: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
product: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110054#
type: Reaction
fast: false

metaR DESAT20 2
product: MODEL1310110054#
is described by: ECO:0000000
reversible: false
name: fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_86751a29_1ee0_4a12_88bf_a6a15333afd5
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: NME7
is encoded by: hsa:29922

metaM oh1 e
initial concentration: 1.0
initial amount: NaN
constant: false
is: C01328
notes: FORMULA: HO CHARGE: -1
boundary condition: false
name: hydroxide ion
is: HMDB01039
is: SBO:0000247
type: Species
has only substance units: false

metaM 5oxpro e
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
has only substance units: false
initial concentration: 1.0
name: 5-oxoprolinate
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00267
is: CHEBI:57606

http://identifiers.org/biomodels.db/MODEL1310110054#_aa178ed8_658d_4a10_bea7_76d4490bbcff
is encoded by: hsa:292
has only substance units: false
initial concentration: NaN
type: Species
is: Q6NVC0
constant: false
name: SLC25A5
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR MM7B2g
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110054#
reactant: MODEL1310110054#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.113
is: SBO:0000176
fast: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#

metaM dadp n
is: HMDB01508
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
constant: false
is: CHEBI:57667
name: dADP(3-)
initial amount: NaN
initial concentration: 1.0
type: Species

metaR r0149
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.14.13.39
product: MODEL1310110054#
kinetic law: MODEL1310110054#
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reversible: true
modifier: MODEL1310110054#
type: Reaction

metaM ump c
is: HMDB00288
is: C00105
constant: false
is: SBO:0000247
name: UMP
is: CHEBI:57865
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_3d1e5c06_c237_4b41_bb9d_231f38408369
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:AI620219
name: _AI620219_1_e

metaR r1421
is: SBO:0000185
product: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
name: Free diffusion
type: Reaction
kinetic law: MODEL1310110054#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110054#

metaR ENGASEly
type: Reaction
is described by: ECO:0000000
product: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
reversible: false
name: endo-beta-N-acetylglucosaminidase, lysosomal
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_7401adf5_6db6_4589_b7fb_f7fe5cdf85e5
boundary condition: true
is: P48448
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:222
has only substance units: false
is: SBO:0000252
name: ALDH3B2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_48012c67_2d82_4591_b350_8e177d492225
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:4697
has only substance units: false
name: NDUFA4
type: Species
is: O00483
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_c907790d_3db9_43e9_8494_89d53caca380
has only substance units: false
boundary condition: true
is encoded by: hsa:10678
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: B3GNT2
type: Species
is: Q9NY97
constant: false

metaM aacoa c
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB01484
initial amount: NaN
constant: false
name: Acetoacetyl-CoA
is: C00332
is: CHEBI:57286

metaR DESAT20 1
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is described by: ECO:0000000
fast: false
product: MODEL1310110054#
modifier: MODEL1310110054#
reversible: false
kinetic law: MODEL1310110054#
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_b8c40e74_da4a_41c4_aa90_a209521b8ab6
has only substance units: false
initial amount: NaN
name: PRDX1
constant: false
initial concentration: NaN
is encoded by: hsa:5052
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_9024eb3c_84e9_4ef7_abbb_b0c2374314f7
is: P34949
is encoded by: hsa:4351
constant: false
name: MPI
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM dcsptn1coa x
constant: false
is: http://identifiers.org/pubchem.compound/47205483
has only substance units: false
is: SBO:0000247
type: Species
is: C16173
is: HMDB06513
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
initial amount: NaN
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A

metaM dadp m
boundary condition: false
constant: false
is: CHEBI:57667
initial amount: NaN
type: Species
is: HMDB01508
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
name: dADP(3-)
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_250974ce_6f49_4e4e_9eb2_2b6c9bfd173b
is encoded by: hsa:7296
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: TXNRD1

http://identifiers.org/biomodels.db/MODEL1310110054#_6027f469_f201_4e10_9ae5_b4debf22274c
boundary condition: true
is encoded by: hsa:1719
is: SBO:0000252
initial concentration: NaN
is: P00374
constant: false
name: DHFR
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_5bf479c1_1edb_48e7_8876_d4eb39e16e8b
initial concentration: NaN
has only substance units: false
name: PPAP2C
is: E9PAY8
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:8612

metaR DOPAtu
reactant: MODEL1310110054#
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
name: Dopamine uniport
is: SBO:0000185
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269
reversible: true
product: MODEL1310110054#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_f9389dad_3a72_4787_a595_e41b9c9db2e9
initial amount: NaN
type: Species
constant: false
is: Q96CA6
name: ACAA1
initial concentration: NaN
boundary condition: true
is encoded by: hsa:30
has only substance units: false
is: SBO:0000252

metaR S3TASE2ly
is: SBO:0000176
type: Reaction
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110054#
product: MODEL1310110054#
fast: false
name: N-acetylglucosamine-3-sulfatase, lysosomal
reversible: true
is described by: ECO:0000000

metaM HC02217 e
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:27647
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
name: prostaglandin-g2

http://identifiers.org/biomodels.db/MODEL1310110054#_34887d61_09d6_40ff_b5b6_f562e3f01338
is encoded by: hsa:6553
name: SLC9A5
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is: Q9NSW9
type: Species
has only substance units: false

metaM oagd3 hs c
boundary condition: false
name: 9-O-Acetylated GD3
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
is: HMDB00286
is: C00029
constant: false
has only substance units: false
type: Species
is: CHEBI:58367
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM urea c
constant: false
type: Species
is: SBO:0000247
is: HMDB00294
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
has only substance units: false
boundary condition: false
is: CHEBI:16199
initial concentration: 1.0
name: Urea
is: C00086
initial amount: NaN

metaR r1396
type: Reaction
reactant: MODEL1310110054#
reversible: false
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
product: MODEL1310110054#
name: EC:2.3.1.21
fast: false
is described by: ECO:0000000
is: SBO:0000176

metaM orot c
type: Species
constant: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: HMDB00226
name: Orotate
is: C00295
initial amount: NaN
has only substance units: false
is: CHEBI:30839
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_b4f53de4_d2b6_4cfe_9ffd_ea8a5b6dc5f2
initial amount: NaN
is: SBO:0000252
is: B4DZR2
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:8854
constant: false
name: ALDH1A2
boundary condition: true

metaR ATPtn
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110054#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
reversible: true
name: ATP diffusion in nucleus
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110054#_4852f211_0771_4ed5_bc5b_c673fa553ac8
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:55650
initial amount: NaN
constant: false
name: PIGV
is: Q9NUD9
boundary condition: true
type: Species

metaR CYTK13n
fast: false
name: cytidylate kinase (dCMP,dATP),nuclear
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110054#
reactant: MODEL1310110054#

metaR MANter
is described by: ECO:0000000
kinetic law: MODEL1310110054#
product: MODEL1310110054#
name: mannose efflux from endoplasmic reticulum
is: SBO:0000185
fast: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
type: Reaction

metaM CE5869 e
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:27485
is: SBO:0000247
is: HMDB02710
notes: FORMULA: C11H22N3O3 CHARGE: 1 INCHI: InChI=1/C11H21N3O3/c12-6-2-1-4-8(13)10(15)14-7-3-5-9(14)11(16)17/h8-9H,1-7,12-13H2,(H,16,17)/p+1/t8-,9-/m1/s1 EHMN_ABBREVIATION: CE5869
name: lysyl-proline
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_483508ef_6c16_4e6a_8560_888edfd8b19c
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:5152
initial amount: NaN
type: Species
name: PDE9A
constant: false

metaR SCP21x
kinetic law: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110054#
name: Sterol carrier protein 2
fast: false
reactant: MODEL1310110054#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.176
modifier: MODEL1310110054#

metaR r0728
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
reversible: true
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110054#
product: MODEL1310110054#

metaR FUT17g
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000176
is described by: ECO:0000269
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.69
name: Galactoside 2-alpha-L-fucosyltransferase 1
fast: false
modifier: MODEL1310110054#
product: MODEL1310110054#

metaR ATPtm
kinetic law: MODEL1310110054#
is described by: ECO:0000269
modifier: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is: SBO:0000185
name: ADP/ATP transporter, mitochondrial
product: MODEL1310110054#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_b30cfe8e_4172_4717_9dc3_93252eff92ed
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:115111
constant: false
type: Species
name: SLC26A7
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_f57df494_5923_49c8_b367_738bfc19597b
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false
name: ASRGL1
is encoded by: hsa:80150
is: Q7L266

metaM HC02217 c
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial concentration: 1.0
name: prostaglandin-g2
constant: false
type: Species
has only substance units: false
is: CHEBI:27647
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR S6T18g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
fast: false
is described by: ECO:0000000
modifier: MODEL1310110054#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.17
reactant: MODEL1310110054#
reversible: false
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.8.2.21

metaM ump g
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
has only substance units: false
initial amount: NaN
name: UMP(2-)
constant: false
is: CHEBI:57865
is: HMDB00288
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_57af7832_c05d_424c_95d4_f69a5feb173b
constant: false
initial concentration: NaN
initial amount: NaN
is: P31040
boundary condition: true
has only substance units: false
is encoded by: hsa:6389
is: SBO:0000252
type: Species
name: SDHA

metaR PDE4
product: MODEL1310110054#
reversible: false
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.4.35
modifier: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.17
is described by: ECO:0000269
name: 3',5'-cyclic-nucleotide phosphodiesterase
is: SBO:0000176
type: Reaction

metaR CERT1gt
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110054#
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
name: ceramide transport protein
reversible: true
reactant: MODEL1310110054#
fast: false
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
is: SBO:0000185

metaR PRASCS
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110054#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.2.6
fast: false
reversible: true
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000269
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_37daa804_51ef_421a_ba01_1f464273909b
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:2590
type: Species
has only substance units: false
is: SBO:0000252
name: GALNT2
is: Q10471
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_a1cbd35d_a6b2_46e8_9333_6a3a545eb436
constant: false
is: SBO:0000252
is encoded by: hsa:1375
has only substance units: false
initial amount: NaN
name: CPT1B
type: Species
is: Q53FV7
boundary condition: true
initial concentration: NaN

metaM urea e
type: Species
is: HMDB00294
is: CHEBI:16199
boundary condition: false
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: C00086
constant: false
name: Urea
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_de1df8c3_3bdc_4121_b5a3_71dc375bd33f
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:2629
initial amount: NaN
type: Species
is: P04062
name: GBA
initial concentration: NaN
boundary condition: true

metaM oagd3 hs e
boundary condition: false
name: 9-O-Acetylated GD3
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:18421
initial concentration: 1.0
is: HMDB02168

http://identifiers.org/biomodels.db/MODEL1310110054#_3b6b311c_a2b9_47d8_9bcd_0318f31ee1d8
initial concentration: NaN
constant: false
is encoded by: hsa:11332
is: SBO:0000252
boundary condition: true
has only substance units: false
name: ACOT7
initial amount: NaN
is: O00154
type: Species

metaR IPDDIx
fast: false
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.2
product: MODEL1310110054#
name: isopentenyl-diphosphate D-isomerase
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ

metaM ppcoa m
constant: false
is: CHEBI:57392
initial amount: NaN
name: Propanoyl-CoA
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: C00100
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial concentration: 1.0
is: HMDB01275

metaM orot e
is: HMDB00226
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
type: Species
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: CHEBI:30839
initial concentration: 1.0
name: orotate

metaR SPHMYLNtg
reactant: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
reversible: true
name: sphingomyelin intracellular transport
product: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is: SBO:0000185
is described by: ECO:0000000

metaR FAOXC160
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
modifier: MODEL1310110054#
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110054#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_51cdd5f5_b88a_41a0_b229_c68b68e8bd51
is: Q02846
boundary condition: true
name: GUCY2D
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:3000
is: SBO:0000252
type: Species
initial concentration: NaN

metaR COAtr
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#
name: COA transporter, endoplasmic reticulum
is: SBO:0000185

metaR TREHe
is described by: ECO:0000269
name: alpha,alpha-trehalase
reversible: false
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
fast: false
type: Reaction
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.28
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000176
modifier: MODEL1310110054#

metaM lnlccoa m
is: http://identifiers.org/pubchem.compound/5462164
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01064
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
name: linoleic coenzyme A
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983

metaR S6TASE9ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110054#
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#

metaR UGLCNACtg
fast: false
type: Reaction
reactant: MODEL1310110054#
is described by: ECO:0000269
modifier: MODEL1310110054#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110054#
name: UDP-GlcNAc Golgi transport via CMP antiport
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD

metaR S4TASE5ly
name: N-acetylgalactosamine-4-sulfatase, lysosomal
modifier: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.12
is: SBO:0000176
product: MODEL1310110054#

metaR r1397
is described by: ECO:0000000
is: SBO:0000176
name: carnitine acetyltransferase EC:2.3.1.7
type: Reaction
fast: false
reversible: false
product: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:

metaR PRFGS
type: Reaction
is described by: ECO:0000269
reversible: false
name: phosphoribosylformylglycinamidine synthase
is: SBO:0000176
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/6.3.5.3
product: MODEL1310110054#
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
fast: false

metaR GALASE11ly
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
reactant: MODEL1310110054#

metaM ksi pre27 g
initial concentration: 1.0
boundary condition: false
is: CHEBI:58053
has only substance units: false
is: C00130
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 27
is: SBO:0000247
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
initial amount: NaN
type: Species
constant: false

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR HPCLx
reactant: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26062.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10468558 NOTES:pristanal is the fatty aldehyde analog of pristanic acid Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde. NJ
fast: false
name: 2-hydroxyphytanoyl-CoA lyase
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110054#_caef9ecb_7164_4bbe_9824_772e42e9db9a
initial concentration: NaN
boundary condition: true
name: PYCRL
is: Q53H96
type: Species
is: SBO:0000252
is encoded by: hsa:65263
initial amount: NaN
constant: false
has only substance units: false

metaR ACONTm
modifier: MODEL1310110054#
is described by: ECO:0000134
kinetic law: MODEL1310110054#
type: Reaction
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.3
product: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
name: Aconitate hydratase

metaR DOLPH Uer
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
fast: false
product: MODEL1310110054#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110054#
name: Dolichol-phosphate phosphohydrolase, human (uterus)
reactant: MODEL1310110054#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110054#_c8d34985_9af0_487c_8fcc_9c6a23ebe8ab
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI222095
constant: false
name: _AI222095_1_m
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR THMPPtm
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:12014993 NOTES:IT
reversible: false
product: MODEL1310110054#
name: Thiamine diphosphate transport in via anion antiport, mitochondria

metaM HC02213 c
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
initial concentration: 1.0
has only substance units: false
name: prostaglandin-e3
is: CHEBI:28031

http://identifiers.org/biomodels.db/MODEL1310110054#_1a219e31_1bcc_4b5c_bb92_1c32132e3999
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q14642
is encoded by: hsa:3632
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: INPP5A

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_788965bf_77d4_4346_ab39_1e21358fece0
is encoded by: hsa:2184
constant: false
name: FAH
has only substance units: false
initial concentration: NaN
is: P16930
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true

metaM m5mpdol L r
type: Species
has only substance units: false
constant: false
notes: FORMULA: C1600H2628N20O470P20 CHARGE: -20
boundary condition: false
initial amount: NaN
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: CHEBI:37634
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_eb6d45e2_5e26_4266_97aa_1bea18dd134c
initial concentration: NaN
is encoded by: hsa:9551
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
constant: false
is: Q6IBB3
initial amount: NaN
name: ATP5J2

metaM dcamp c
type: Species
is: C03794
constant: false
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
has only substance units: false
is: HMDB00536
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57567
is: SBO:0000247
name: N6-(1,2-Dicarboxyethyl)-AMP

http://identifiers.org/biomodels.db/MODEL1310110054#_3184d67b_c9b4_4969_b306_1e6e2ab5c037
is encoded by: hsa:2984
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
name: GUCY2C
is: SBO:0000252
is: P25092

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaR NACHEX19ly
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
reactant: MODEL1310110054#

metaM pail3p hs c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
boundary condition: false
constant: false
is: CHEBI:58088
initial amount: NaN
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_df58ca30_3ce6_4984_b466_d68e26fa4b47
is: SBO:0000252
has only substance units: false
is encoded by: hsa:100128062
initial amount: NaN
boundary condition: true
constant: false
type: Species
name: _100128062_1_m
initial concentration: NaN

metaR HSAT4ly
reversible: false
reactant: MODEL1310110054#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
product: MODEL1310110054#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110054#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaR ILEtec
is: SBO:0000185
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
product: MODEL1310110054#
name: L-isoleucine transport via diffusion (extracellular to cytosol)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_99b48293_a910_4e37_b163_c6bf1ab9061c
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:2618
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q59HH3
type: Species
name: GART

metaR DOLPMT2 Ler
reactant: MODEL1310110054#
reversible: false
kinetic law: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110054#
type: Reaction
fast: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)

http://identifiers.org/biomodels.db/MODEL1310110054#_12cdea46_0554_4228_ab8f_3875e8de1275
constant: false
is: Q5QPH3
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: ACSS2
is encoded by: hsa:55902

metaM 3dsphgn c
is: CHEBI:58299
boundary condition: false
has only substance units: false
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
constant: false
initial concentration: 1.0
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
is: SBO:0000247
initial amount: NaN
is: HMDB01480
type: Species

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaR DOPASULT
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000269
fast: false
name: Dopamine Sulfotransferase
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.1
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)
is: SBO:0000176
modifier: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_93c36a8b_8e2d_4702_9dc9_f4673f3adcbd
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
name: ACSL3
initial concentration: NaN
is: O95573
has only substance units: false
is encoded by: hsa:2181

metaM HC02213 e
boundary condition: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:28031
type: Species
name: prostaglandin-e3

metaR RE0691C
is: SBO:0000176
name: RE0691
is described by: ECO:0000000
product: MODEL1310110054#
reversible: true
type: Reaction
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110054#_c3c41411_022f_494c_a612_314abb11fbcf
is encoded by: hsa:2651
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: GCNT2
initial amount: NaN
boundary condition: true
is: Q08M29
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_465f9380_3786_43f5_b490_8925e5f133e4
is encoded by: hsa:570
constant: false
name: BAAT
is: Q14032
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN

metaM xol7aone c
name: 7alpha-hydroxycholest-4-en-3-one
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
initial concentration: 1.0
boundary condition: false
is: HMDB01993
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17899
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_425e1f9e_cbcb_4bde_b383_889edecadb2e
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:8760
boundary condition: true
name: CDS2
initial amount: NaN
is: SBO:0000252
is: O95674
constant: false

metaM hs deg17 l
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
initial concentration: 1.0
is: CHEBI:21338
type: Species
is: HMDB02704
name: heparan sulfate, degradation product 17

metaM ksi deg39 l
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C48H81N3O36 CHARGE: 0
is: HMDB00143
constant: false
initial amount: NaN
name: keratan sulfate I, degradation product 39
is: CHEBI:12936
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_6aa50d30_ef06_43d7_b79f_2a65a0ab5dd3
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: P05166
constant: false
is encoded by: hsa:5096
name: PCCB

metaR EX HC01361 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Dihydroneopterin
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_a349c215_bd1b_4734_a05c_b9dd34694d3c
initial concentration: NaN
is encoded by: hsa:196883
has only substance units: false
is: SBO:0000252
constant: false
type: Species
name: ADCY4
is: Q8NFM4
boundary condition: true
initial amount: NaN

metaM dolmanp L c
initial amount: NaN
boundary condition: false
constant: false
name: Dolichyl phosphate D-mannose, human liver homolog
is: CHEBI:15809
type: Species
is: SBO:0000247
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial concentration: 1.0
has only substance units: false

metaM cholcoar x
boundary condition: false
initial amount: NaN
is: HMDB02178
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
is: CHEBI:58677

metaR FAOXC10DCC8DCx
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10DC-->C8DC)
type: Reaction

metaR r0142
kinetic law: MODEL1310110054#
is: SBO:0000176
type: Reaction
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.6.1.5
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
fast: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
reversible: false
reactant: MODEL1310110054#
modifier: MODEL1310110054#
is described by: ECO:0000000

metaM 5fthf m
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB01562
is: CHEBI:57457
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
name: 5-formyltetrahydrofolate(2-)
constant: false

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_685321bb_0f6b_4b4e_84be_80bc6b85f533
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
name: SLC24A4
is encoded by: hsa:123041

http://identifiers.org/biomodels.db/MODEL1310110054#_6bdac6fe_3a9d_4c6b_98e0_df2be9e90b7c
name: SULT1A1
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:6817
boundary condition: true
type: Species
initial concentration: NaN

metaM dhap x
is: CHEBI:57642
is: HMDB01473
boundary condition: false
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/3411
constant: false
initial amount: NaN
is: C00111
initial concentration: 1.0
is: SBO:0000247
name: Dihydroxyacetone phosphate

metaM fadh2 c
is: CHEBI:58307
name: FADH2(2-)
constant: false
initial concentration: 1.0
is: HMDB01197
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352

metaM ksii core2 pre10 g
initial concentration: 1.0
is: CHEBI:28067
boundary condition: false
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 10
constant: false

metaM no c
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: Nitric oxide
initial amount: NaN
type: Species
is: HMDB03378
is: SBO:0000247
is: CHEBI:16480
is: C00533
constant: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533

metaM ksii core2 deg4 l
name: keratan sulfate II (core 2-linked), degradation product 4
notes: FORMULA: C58H95N5O43SX CHARGE: -1
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00812
is: CHEBI:16953
initial amount: NaN

metaM ksi pre32 g
boundary condition: false
is: CHEBI:28067
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 32

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_8aeee52d_dcf9_487e_ac8e_2a3d9b537071
has only substance units: false
initial concentration: NaN
is: P15104
is: SBO:0000252
name: GLUL
boundary condition: true
is encoded by: hsa:2752
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_61b0d7d9_89c4_4dea_8248_731a8f33ffa2
is encoded by: hsa:4126
initial amount: NaN
type: Species
boundary condition: true
name: MANBA
is: SBO:0000252
initial concentration: NaN
constant: false
is: O00462
has only substance units: false

metaR r0559
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reversible: true
modifier: MODEL1310110054#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3
reactant: MODEL1310110054#
is described by: ECO:0000000
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
fast: false
type: Reaction

metaR DAG HSter
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: false
name: diacylglycerol ER export

metaM hexdectecoa x
type: Species
initial amount: NaN
has only substance units: false
constant: false
name: 2,4,7,10-hexadecatetraenoylcoa
is: SBO:0000247
is: HMDB02288
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0

metaR It
fast: false
type: Reaction
is described by: ECO:0000269
name: Iodide uniport
product: MODEL1310110054#
reversible: true
reactant: MODEL1310110054#
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
is: SBO:0000185

metaM occoa m
name: Octanoyl-CoA (n-C8:0CoA)
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: C01944
is: HMDB01070
boundary condition: false
constant: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: CHEBI:57386

metaR RE1519M
product: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
reversible: true
modifier: MODEL1310110054#
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.3.99.13
type: Reaction
is described by: ECO:0000000
name: RE1519
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6

http://identifiers.org/biomodels.db/MODEL1310110054#_fe3476e3_f444_4381_8349_f6f1d2876899
has only substance units: false
is: SBO:0000252
name: IREB2
initial concentration: NaN
is: P48200
type: Species
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:3658

metaR 2DR1PP
fast: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
reversible: false
type: Reaction
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
name: 2-deoxy-D-ribose 1-phosphate phosphorylase

metaM leuktrC4 c
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB01198
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
type: Species
name: leukotriene C4(2-)
constant: false
is: CHEBI:57973

metaM cspg a l
constant: false
boundary condition: false
type: Species
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
has only substance units: false
is: HMDB02183
is: CHEBI:36005
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR PPA
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.1
reversible: false
name: inorganic diphosphatase
is described by: ECO:0000269
modifier: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
kinetic law: MODEL1310110054#
product: MODEL1310110054#

metaR r0558
product: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110054#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.5.1.3
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
is: SBO:0000176

metaR B3GNT310g
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is described by: ECO:0000254
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110054#
fast: false

metaR PI345P5P
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.56
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
reversible: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.1.3.36
reactant: MODEL1310110054#
product: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false

metaR H2Ot
name: H2O transport via diffusion
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:renamed from H20t5 to H2Ot NCD
reactant: MODEL1310110054#
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110054#
fast: false
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#

metaM CE5236 n
initial concentration: 1.0
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
initial amount: NaN
is: CHEBI:28002
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB03952
constant: false
type: Species
name: O2'-4a-cyclic-tetrahydrobiopterin

metaM CE2431 m
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
name: cis-deca-4-enoyl-CoA
is: SBO:0000247
is: CHEBI:57795
initial concentration: 1.0

metaR ADA
modifier: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
is described by: ECO:0000269
reversible: false
fast: false
name: Adenosine deaminase
type: Reaction
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.5.4.4
kinetic law: MODEL1310110054#

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_cd76281e_2a27_4765_976e_891c1bd2c5cc
is encoded by: hsa:AI480132
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: _AI480132_1_c

http://identifiers.org/biomodels.db/MODEL1310110054#_6d263654_476e_4c03_b98d_468007621346
name: SDHB
type: Species
initial concentration: NaN
is encoded by: hsa:6390
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P21912
boundary condition: true

metaM hexe3coa x
is: HMDB06522
name: 3-hexenoylcoa
constant: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM ac e
type: Species
boundary condition: false
is: CHEBI:30089
is: HMDB00042
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
constant: false
name: acetate
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR MCLOR
reactant: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.1.1.27
modifier: MODEL1310110054#
name: 3-Mercaptolactate:NAD+ oxidoreductase
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
is: SBO:0000176
product: MODEL1310110054#
is described by: ECO:0000269

metaM ksi deg10 l
boundary condition: false
initial amount: NaN
is: HMDB00812
has only substance units: false
is: CHEBI:16953
name: keratan sulfate I, degradation product 10
notes: FORMULA: C188H302N13O163S9 CHARGE: -9
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR DCTPtn
product: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
reactant: MODEL1310110054#
name: dCTP diffusion in nucleus
is described by: ECO:0000000
is: SBO:0000185

metaR ASNSERNaEx
is described by: ECO:0000269
reactant: MODEL1310110054#
modifier: MODEL1310110054#
fast: false
type: Reaction
product: MODEL1310110054#
name: L-serine/L-asparagine Na-dependent exchange (Asn-L in)
reversible: false
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185

metaR CHOLt4
modifier: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
name: choline, sodium cotransport
kinetic law: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000269

metaR BILIRUBt2
fast: false
is described by: ECO:0000269
reactant: MODEL1310110054#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110054#
name: bilirubin transport via bicarbonate countertransport
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
reversible: true
kinetic law: MODEL1310110054#

metaR ARSA
fast: false
reversible: false
kinetic law: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ
is described by: ECO:0000000
name: Arylsulfatase A
is: SBO:0000176
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.1.6.8

metaM fad r
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: HMDB01248
has only substance units: false
is: SBO:0000247
constant: false
name: Flavin adenine dinucleotide oxidized
is: CHEBI:16238
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0

metaM 3ohdcoa x
constant: false
is: HMDB06402
type: Species
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
initial amount: NaN
has only substance units: false
name: 3-oxopalmitoyl-CoA(4-)
is: CHEBI:57349
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR r0556
is version of: http://identifiers.org/ec-code/1.14.19.1
type: Reaction
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
reversible: true
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
is described by: ECO:0000000
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_849641f5_e388_445a_a929_8511fbea5da3
constant: false
is encoded by: hsa:3707
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P27987
boundary condition: true
name: ITPKB
initial concentration: NaN
type: Species

metaR FADH2tx
reactant: MODEL1310110054#
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
product: MODEL1310110054#
is described by: ECO:0000000
name: FADH2 transporter, peroxisomal

http://identifiers.org/biomodels.db/MODEL1310110054#_426f899d_0baf_45c4_b243_d75b6c4b64eb
name: SULT1A3
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: Q1ET61
is encoded by: hsa:6818
boundary condition: true
type: Species
is: SBO:0000252

metaM ac c
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial concentration: 1.0
name: acetate
has only substance units: false
is: CHEBI:30089
is: SBO:0000247
is: HMDB00042
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_f2885533_8f12_4907_835f_16491f011079
is encoded by: hsa:6818
is: P50224
type: Species
name: SULT1A3
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false

metaR FATP6t
fast: false
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is described by: ECO:0000269
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/6.2.1.7
type: Reaction
is: SBO:0000185
name: fatty acid electroneutral transport
reactant: MODEL1310110054#
reversible: true
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110054#

metaR DGK2m
reactant: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.8 Confidence Level: 2 AUTHORS: NOTES:Added EC- JLR IT
fast: false
is described by: ECO:0000000
name: deoxyguanylate kinase (dGMP:dATP) (mitochondrial)
is: SBO:0000176
type: Reaction

metaR AMETtd
name: diffusion of S-Adenosyl-L-methionine
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
reversible: true
is described by: ECO:0000134
product: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_1b686280_c892_46b5_9d26_75df3ea338ba
is encoded by: hsa:109
is: B3KT86
initial concentration: NaN
has only substance units: false
name: ADCY3
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true

metaR PIPLCn
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.4.11
name: phosphatidylinositol phospholipase C, nucleus
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
reversible: false

metaM Tn antigen l
boundary condition: false
initial concentration: 1.0
name: Tn antigen
is: C04383
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C8H14NO5X CHARGE: 0

metaM 3mop e
is: SBO:0000247
has only substance units: false
name: 3-methyl-2-oxopentanoate
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
is: HMDB00491
is: CHEBI:28654
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM dcdp n
is: SBO:0000247
is: CHEBI:58593
has only substance units: false
constant: false
initial concentration: 1.0
name: dCDP(3-)
type: Species
is: HMDB01245
initial amount: NaN
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_57d69eaf_a533_4b67_83bd_8835ddd19844
type: Species
constant: false
is encoded by: hsa:1806
is: SBO:0000252
has only substance units: false
name: DPYD
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q12882

metaM dhdascb c
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
is: HMDB01264
is: CHEBI:58070
initial amount: NaN
name: dehydroascorbide(1-)

http://identifiers.org/biomodels.db/MODEL1310110054#_0533a314_829b_49cb_b60b_31ddab4cc778
name: ATP8A1
initial amount: NaN
is encoded by: hsa:10396
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
is: Q9Y2Q0
initial concentration: NaN
type: Species

metaM ksi pre6 g
is: HMDB00175
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 6
type: Species
initial amount: NaN
is: CHEBI:58053
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C107H174N7O80SX CHARGE: -2
constant: false
boundary condition: false
is: C00130

metaR OCDCEAtr
reversible: true
product: MODEL1310110054#
is: SBO:0000185
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
name: fatty acid transport via diffusion
reactant: MODEL1310110054#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110054#_ba610d35_3a42_42ad_933b_67cc57f6ea0d
has only substance units: false
name: B4GALT1
is: P15291
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2683
type: Species
initial amount: NaN

metaM no e
type: Species
initial amount: NaN
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
initial concentration: 1.0
is: HMDB03378
boundary condition: false
name: Nitric oxide
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:16480
is: C00533

metaM ksi pre19 g
boundary condition: false
type: Species
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
constant: false
is: CHEBI:58053
is: HMDB00175
is: C00130
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 19
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_979d92a8_e1cf_4120_89d9_ca2479661704
name: COX2
initial concentration: NaN
is: Q7GXZ8
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:4513
constant: false
initial amount: NaN
type: Species

metaM fad m
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: C00016
is: HMDB01248
constant: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
has only substance units: false
is: CHEBI:16238
name: Flavin adenine dinucleotide oxidized

metaM dcdp m
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:58593
initial concentration: 1.0
constant: false
is: HMDB01245
boundary condition: false
type: Species
name: dCDP(3-)

metaR GALGLUSIDEtl
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reversible: true
type: Reaction
name: galgluside hs intracellular transport
fast: false
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#

metaR RE0944E
fast: false
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.17
is described by: ECO:0000000
modifier: MODEL1310110054#
type: Reaction
is: SBO:0000176
name: RE0944
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.1
reversible: true

metaR FAOXC61m
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_ed162c4b_fcb4_4974_a251_91dc086b228e
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
name: PDE9A
boundary condition: true
is encoded by: hsa:5152
has only substance units: false

metaM HC00361 c
initial concentration: 1.0
name: sedoheptulose 1,7-bisphosphate(4-)
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:58335
type: Species
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447

metaR HISyLATthc
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Histidine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaR LEUKTRB4t
product: MODEL1310110054#
name: leukotriene B4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110054#
type: Reaction
fast: false
reactant: MODEL1310110054#
reversible: true
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110054#_85a2bf27_a427_4863_91d7_7657f4beca25
is encoded by: hsa:6547
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
name: SLC8A3

metaR r0553
is described by: ECO:0000000
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
type: Reaction
reactant: MODEL1310110054#
product: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
fast: false
kinetic law: MODEL1310110054#
is: SBO:0000176

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_d12a31f5_3545_4869_82fb_76758e427aa6
is encoded by: hsa:1036
is: Q16878
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: CDO1
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_5bf61b7f_e263_4075_b3ae_091c53886562
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
name: _R51273_1_c
is encoded by: hsa:R51273
has only substance units: false
type: Species
is: SBO:0000252

metaM leuktrC4 e
is: HMDB01198
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
name: leukotriene C4(2-)
constant: false
is: CHEBI:57973

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_1acb6575_926c_4aee_9190_7715d5a68495
has only substance units: false
name: SLC38A4
type: Species
is: Q969I6
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:55089
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_9152367a_b5de_4326_8366_24d1a8d213d8
is: SBO:0000252
constant: false
name: PRDX2
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:7001
type: Species

metaM hx2coa x
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: trans-Hex-2-enoyl-CoA
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_b26e5bdd_03e3_4543_8893_d137ae783252
has only substance units: false
constant: false
is encoded by: hsa:410
type: Species
initial amount: NaN
name: ARSA
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: P15289

metaR IDOURtly
product: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110054#
name: iduronate transport into lysososme
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000269

metaR ADNK1m
fast: false
is described by: ECO:0000000
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.20 Confidence Level: 1 AUTHORS: NOTES:IT
name: adenosine kinase, mitochondrial
product: MODEL1310110054#
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110054#

metaR SPODM
product: MODEL1310110054#
is described by: ECO:0000269
reversible: false
type: Reaction
modifier: MODEL1310110054#
is: SBO:0000176
name: superoxide dismutase
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.15.1.1

metaM HC02175 e
is: CHEBI:27689
initial concentration: 1.0
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
boundary condition: false
name: caprate
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false

metaM acac c
constant: false
initial amount: NaN
name: acetoacetate
is: HMDB00060
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:13705
type: Species
has only substance units: false

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_1c31dd93_250f_4e43_a732_5a869768243c
type: Species
is: P24666
is: SBO:0000252
name: ACP1
constant: false
is encoded by: hsa:52
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_2802384f_160c_487c_a7fb_f90739a93d21
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000297
is encoded by: hsa:2720
initial concentration: NaN
type: Species
has part: P34059
is encoded by: hsa:2588
has part: Q99519
is encoded by: hsa:4758
has part: P16278
initial amount: NaN
has part: P10619
is encoded by: hsa:5476
name: GALNS:GLB1:NEU1:CTSA

metaR DOLPGT2 Ler
product: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is described by: ECO:0000000
is: SBO:0000176
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.265
reactant: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#

metaR r1298
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110054#
reversible: false
is: SBO:0000185
name: Vesicular transport
type: Reaction
is described by: ECO:0000000
fast: false

metaR ADPT
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (353.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.7 Confidence Level: 4 AUTHORS: PMID:14674717,PMID:15196008 NOTES:
fast: false
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.7
name: adenine phosphoribosyltransferase
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110054#_metaM_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_g
is: CHEBI:61648
initial concentration: 1.0
boundary condition: false
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C96H165N4O60FULLRCO CHARGE: 0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_d2079131_091f_4794_b82b_867b219fb4e5
initial concentration: NaN
name: SLC7A3
constant: false
is: Q8WY07
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:84889

metaR DM gpi sig er
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaM doldp L r
is: CHEBI:15750
has only substance units: false
boundary condition: false
notes: FORMULA: C1080H1758O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
initial concentration: 1.0
initial amount: NaN
type: Species
name: Dolichol diphosphate, human liver homolog
is: SBO:0000247
constant: false

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaR 4MOPt2im
is described by: ECO:0000000
reversible: false
is: SBO:0000185
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
reactant: MODEL1310110054#
type: Reaction
fast: false
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
product: MODEL1310110054#

metaR GGH 6DHFe
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is: SBO:0000176
product: MODEL1310110054#
reversible: false
fast: false
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
name: Gamma-glutamyl hydrolase (6DHF), extracellular
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9

metaR HMGCOASim
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
type: Reaction
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.3.3.10
fast: false
reversible: false
is: SBO:0000176
name: Hydroxymethylglutaryl CoA synthase (ir)
product: MODEL1310110054#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110054#_9560e7ab_cdd5_481e_8c73_289a589b91e4
initial amount: NaN
constant: false
is encoded by: hsa:3038
boundary condition: true
name: HAS3
has only substance units: false
type: Species
is: SBO:0000252
is: Q96RV2
initial concentration: NaN

metaR GALASE19ly
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000269
modifier: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.1.6.4
name: beta-galactosidase, lysosomal
type: Reaction

metaR FORMCOAtx
kinetic law: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism see Verhoeven 11591435 and clayton 11356171 - added for peroxisomal oxidation of fatty acids NJ
type: Reaction
fast: false
name: formyl coa transport
is described by: ECO:0000000
reversible: true
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_6a1f012b_c72d_4cf2_a417_356e5ec18177
initial amount: NaN
boundary condition: true
is: P08842
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: STS
is encoded by: hsa:412
constant: false

metaR r1299
fast: false
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000185
name: Vesicular transport

metaR CSPG Btly
name: chondroitin sulfate B transport, extracellular to lysosome
kinetic law: MODEL1310110054#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110054#
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_d4c138e1_d8f7_4c9b_94d7_22b0e92cab1b
is encoded by: hsa:8560
is: SBO:0000252
initial amount: NaN
constant: false
name: DEGS1
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR FAOXC164x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_124cddc0_a483_45ff_b589_07ca481e11e5
name: PLD2
boundary condition: true
constant: false
type: Species
is encoded by: hsa:5338
is: O14939
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM cspg a e
has only substance units: false
initial amount: NaN
is: CHEBI:17568
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
constant: false
is: SBO:0000247
boundary condition: false
is: C00106
type: Species
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
is: HMDB00300
initial concentration: 1.0

metaM ksi pre17 g
initial amount: NaN
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 17
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
is: CHEBI:28067

metaM 4hexdtetcoa m
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: HMDB02288
name: 4,7,10,13-hexadecatetraenoylcoa
initial amount: NaN
type: Species
has only substance units: false

metaM ksii core4 pre4 g
is: HMDB00175
initial concentration: 1.0
is: SBO:0000247
is: C00130
type: Species
has only substance units: false
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 4
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: CHEBI:58053
boundary condition: false
constant: false

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaM fadh2 m
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:58307
initial amount: NaN
is: SBO:0000247
is: HMDB01197
name: Flavin adenine dinucleotide reduced
type: Species
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: C01352

http://identifiers.org/biomodels.db/MODEL1310110054#_f15c0a79_86da_4e9d_bb56_a1e6c155f0b2
has only substance units: false
is encoded by: hsa:128869
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
type: Species
name: PIGU
is: Q9H490

metaM ac m
is: SBO:0000247
is: HMDB00042
constant: false
name: acetate
boundary condition: false
has only substance units: false
is: CHEBI:30089
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
type: Species
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_metaM_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_e
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
constant: false
is: C00124
is: CHEBI:0
notes: FORMULA: C96H165N4O60FULLRCO CHARGE: 0
boundary condition: false
is: HMDB00143
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
initial amount: NaN

metaR FUCASE2ly
is described by: ECO:0000000
reversible: false
fast: false
is: SBO:0000176
product: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.51
name: alpha-fucosidase, lysosomal
modifier: MODEL1310110054#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_f2116373_1945_433c_bcc7_732e18565d5d
is: Q7LBE3
is encoded by: hsa:115019
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: SLC26A9

http://identifiers.org/biomodels.db/MODEL1310110054#_5a178b85_60b0_4f2b_8184_b83923938f44
has only substance units: false
is encoded by: hsa:6541
is: SBO:0000252
name: SLC7A1
is: P30825
initial amount: NaN
constant: false
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_cfcbee7e_a324_4f2c_9e1c_4d5b368af296
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is: O14561
is encoded by: hsa:4706
name: NDUFAB1
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_44fea262_dbab_461a_a77c_076f22922f11
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: CHST5
is encoded by: hsa:23563
type: Species
boundary condition: true
is: Q9GZS9

metaR RTOTAL2FATPc
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

metaM prostge2 c
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:606564
is: HMDB01220
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
initial amount: NaN
name: prostaglandin E2(1-)

metaR MCCCrm
fast: false
is version of: http://identifiers.org/ec-code/6.4.1.4
reactant: MODEL1310110054#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
is: SBO:0000176
name: methylcrotonoyl-CoA carboxylase, mitochondrial
product: MODEL1310110054#
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_4b33f050_f3c5_435e_bdc6_79a39620e842
constant: false
is: O15427
type: Species
initial amount: NaN
name: SLC16A3
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:9123
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_f770bccb_a08e_4f63_b962_4813806c28ce
initial amount: NaN
constant: false
type: Species
is: Q92911
boundary condition: true
name: SLC5A5
initial concentration: NaN
is encoded by: hsa:6528
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_79edb6ed_f98d_4c98_bdc6_63889d634c17
is: A0S0A7
boundary condition: true
initial amount: NaN
name: NOS3
initial concentration: NaN
type: Species
is encoded by: hsa:4846
is: SBO:0000252
constant: false
has only substance units: false

metaM core4 g
type: Species
initial amount: NaN
is: CHEBI:16478
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
name: Core 4
notes: FORMULA: C24H40N3O15X CHARGE: 0
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_4f8011e9_4bae_424a_82f3_2db8e4d49fad
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: SLC26A7
is: Q8TE54
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:115111

metaR B3GNT12g
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.1.149
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
fast: false
reversible: false
modifier: MODEL1310110054#
is described by: ECO:0000269
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (10678.1) or (10678.2) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ

metaM co e
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: carbon monoxide
constant: false
type: Species
is: CHEBI:17245
initial concentration: 1.0
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
is: HMDB01361
has only substance units: false

metaR r0661
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: false
kinetic law: MODEL1310110054#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_07e2a331_1c99_4311_a2c5_2a53e672f753
has only substance units: false
name: FUT8
initial concentration: NaN
initial amount: NaN
is: G3V5N0
is encoded by: hsa:2530
constant: false
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_134b66c1_00c3_4c7e_832e_637c10ab967b
type: Species
constant: false
name: ACOT4
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:122970
is: Q8N9L9

metaM acgam c
is: HMDB00215
boundary condition: false
is: CHEBI:17411
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
name: N-acetyl-D-glucosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_d9e21d02_23b5_4e5d_80f8_6f27810a2ae3
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:145226
is: SBO:0000252
type: Species
initial concentration: NaN
name: RDH12
is: Q96NR8

metaR r1088
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110054#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110054#
reversible: true
fast: false
kinetic law: MODEL1310110054#
name: Active transport

http://identifiers.org/biomodels.db/MODEL1310110054#_metaM_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C96H165N4O60FULLRCO CHARGE: 0
boundary condition: false
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
type: Species
is: HMDB00143
constant: false
initial concentration: 1.0
is: CHEBI:12936
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_ddca36a9_fb22_4fd1_981c_33ba56c691be
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:26289
is: SBO:0000252
has only substance units: false
name: AK5
is: Q9Y6K8
type: Species
boundary condition: true

metaM prostge2 e
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: CHEBI:606564
is: SBO:0000247
name: prostaglandin E2(1-)
has only substance units: false
is: HMDB01220
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaM 13 cis retn c
initial amount: NaN
boundary condition: false
constant: false
is: D00348
is: HMDB06219
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7847414
initial concentration: 1.0
name: 13-cis-retinoate
type: Species

metaR r0660
is: SBO:0000176
fast: false
product: MODEL1310110054#
reversible: true
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
modifier: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.5.1.2
kinetic law: MODEL1310110054#

metaM 3mop m
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
constant: false
name: 3-methyl-2-oxopentanoate
is: HMDB00491
is: CHEBI:28654
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
initial amount: NaN
initial concentration: 1.0

metaM fad x
constant: false
name: Flavin adenine dinucleotide oxidized
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16238
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: HMDB01248
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_23ff0d3b_8cb4_4749_8217_5b13117ff1db
has only substance units: false
boundary condition: true
is encoded by: hsa:212
constant: false
is: Q5JZF5
is: SBO:0000252
initial concentration: NaN
name: ALAS2
initial amount: NaN
type: Species

metaM hs deg24 l
is: CHEBI:15748
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C31H50NO26 CHARGE: -1
initial amount: NaN
name: GlcNAc-GlcA-(Gal)2-Xyl
initial concentration: 1.0
is: HMDB00127
constant: false
has only substance units: false

metaM ksi pre28 g
is: CHEBI:58053
is: HMDB00175
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
name: keratan sulfate I biosynthesis, precursor 28
has only substance units: false
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
is: SBO:0000247
is: C00130

metaM dhf m
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial amount: NaN
constant: false
boundary condition: false
name: dihydrofolate(2-)
initial concentration: 1.0
is: HMDB01056
is: SBO:0000247
has only substance units: false
is: CHEBI:57451
type: Species

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_c3461e88_e1d4_4746_9d5a_bc29a2d59e77
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4166
boundary condition: true
name: CHST6
initial concentration: NaN
constant: false
type: Species
is: Q9GZX3

metaM 5aop m
has only substance units: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: SBO:0000247
is: C00430
initial amount: NaN
is: HMDB01149
constant: false
type: Species
boundary condition: false
name: 5-Amino-4-oxopentanoate
initial concentration: 1.0
is: CHEBI:17549

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaR DRBK
is: SBO:0000176
fast: false
reactant: MODEL1310110054#
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.1.15
reversible: false
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.15 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
name: Deoxyribokinase
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_a71348b3_e0d3_4064_80c3_58bdcb045cf8
is: SBO:0000252
type: Species
name: _AI348006_1_c
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:AI348006
boundary condition: true
initial concentration: NaN

metaR RBTt
is described by: ECO:0000000
type: Reaction
name: ribitol transport via passive diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110054#
fast: false
reversible: false
product: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000185

metaR SUCCt4 2
fast: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
name: succinate transport via sodium symport

metaM acac e
is: SBO:0000247
is: HMDB00060
constant: false
is: CHEBI:13705
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
name: acetoacetate
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR RE3626M
is described by: ECO:0000000
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
modifier: MODEL1310110054#
reversible: false
name: RE3626
product: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6

metaM ksii core2 deg5 l
has only substance units: false
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 5
boundary condition: false
is: HMDB00143
is: CHEBI:12936
type: Species
is: SBO:0000247
notes: FORMULA: C50H82N4O38SX CHARGE: -1
initial amount: NaN
constant: false

metaM cs a deg2 l
is: HMDB00127
is: SBO:0000247
is: CHEBI:15748
type: Species
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C37H55NO38S2 CHARGE: -4
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_1c2e4eea_ff23_45de_8d28_49ad7010e817
is encoded by: hsa:126410
constant: false
is: Q6NT55
has only substance units: false
name: CYP4F22
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_09412d3e_d34a_4c50_bb51_2cee4c460a29
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:4967
is: Q02218
name: OGDH
constant: false
is: SBO:0000252

metaM dump c
name: dUMP
constant: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: C00365
initial amount: NaN
boundary condition: false
is: HMDB01409
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:246422

metaM fadh2 r
is: CHEBI:58307
name: FADH2(2-)
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB01197

metaM m2mn l
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
is: HMDB06537
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR SERTHRNaEx
kinetic law: MODEL1310110054#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000185
name: L-serine/L-threonine Na-dependent exchange (Ser-L in)
type: Reaction
reversible: false

metaR G16MT U
reactant: MODEL1310110054#
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110054#
name: Glycolipid 1,6-alpha-D-mannosyltransferase (uterus)
product: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110054#_c441d52f_f6c5_4d0f_a6ad_c16ca4fb2337
initial concentration: NaN
name: NDUFB5
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: O43674
is encoded by: hsa:4711
is: SBO:0000252
has only substance units: false

metaM dcdp c
constant: false
is: C00705
is: SBO:0000247
type: Species
is: CHEBI:58593
is: HMDB01245
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: dCDP
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_5ccc267c_1333_4602_8450_bc452063d279
has part: Q08ET0
is encoded by: hsa:516
name: ATP5H:ATP5L:NSF:ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
has part: Q6IBB3
is encoded by: hsa:522
has part: P05496
has part: P56385
has part: P46459
is encoded by: hsa:9551
constant: false
initial concentration: NaN
is: SBO:0000297
type: Species
is encoded by: hsa:10632
is encoded by: hsa:521
has part: A0PJH2
is encoded by: hsa:515
is encoded by: hsa:4905
has only substance units: false
initial amount: NaN
boundary condition: true
has part: O75964
is encoded by: hsa:10476

metaR GALASE3ly
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110054#
name: beta-galactosidase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
reversible: false
modifier: MODEL1310110054#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110054#
is described by: ECO:0000000

metaR XYLUR
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.10
reversible: true
is: SBO:0000176
name: xylulose reductase
kinetic law: MODEL1310110054#
fast: false
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
product: MODEL1310110054#
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_aaf9e6b6_e05f_4822_b38e_144531f8a753
initial concentration: NaN
is: P59796
is encoded by: hsa:257202
type: Species
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
name: GPX6
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_6a0479e9_c60a_4475_8c7d_d6ea86d8e670
is: Q16718
initial amount: NaN
is encoded by: hsa:4698
constant: false
has only substance units: false
name: NDUFA5
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species

metaM 3ohdcoa m
type: Species
name: 3-oxopalmitoyl-CoA(4-)
has only substance units: false
is: HMDB06402
is: CHEBI:57349
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_73ecf7d2_f194_45a4_af52_59acfff288d9
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
name: _AI222095_1_e
constant: false
initial amount: NaN
is encoded by: hsa:AI222095

metaM dump n
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: HMDB01409
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: dUMP(2-)
is: CHEBI:246422
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_d1cc02f6_045c_4e41_88cb_ba8f6b6a9f0e
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: VNN3:VNN2:VNN1
is encoded by: hsa:55350
is: SBO:0000297
initial concentration: NaN
boundary condition: true

metaM pacald c
is: HMDB06236
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
type: Species
is: CHEBI:16424
has only substance units: false
name: phenylacetaldehyde
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_3b541c83_af09_45d7_8200_b84d8089d399
is: Q9Y2C3
constant: false
boundary condition: true
is encoded by: hsa:10317
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: B3GALT5
initial amount: NaN

metaM glu5sa m
is: C01165
is: SBO:0000247
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
type: Species
is: HMDB02104
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:17232
initial amount: NaN
name: L-Glutamate 5-semialdehyde
has only substance units: false

metaM mal L c
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: HMDB00156
name: (S)-malate(2-)
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
initial concentration: 1.0
is: CHEBI:15589
has only substance units: false

metaM ksi pre33 g
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00175
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 33
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
is: CHEBI:58053
initial concentration: 1.0
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110054#_ada57119_5d17_4f02_b8e0_34151408e991
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:204
name: AK2
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: P54819

metaR r0129
reactant: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
kinetic law: MODEL1310110054#
fast: false
reversible: true
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.40
modifier: MODEL1310110054#

metaR RE3001M
reversible: true
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.34
name: RE3001
fast: false
reactant: MODEL1310110054#

metaM ksi e
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:17268
name: keratan sulfate I
has only substance units: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
type: Species
is: HMDB00211
boundary condition: false
constant: false

metaM fald e
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
is: SBO:0000247
initial amount: NaN
name: formaldehyde
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: HMDB01426
has only substance units: false
is: CHEBI:16842

http://identifiers.org/biomodels.db/MODEL1310110054#_8cc866c5_c4aa_4bb7_aaad_889cd0aa2064
name: _AA526438_1_c
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AA526438
initial amount: NaN
is: SBO:0000252
type: Species
constant: false

metaM xyl D l
is: CHEBI:15936
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
boundary condition: false
initial amount: NaN
type: Species
name: aldehydo-D-xylose
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_1ec7084d_1db1_40e3_8df0_759b5fa9c8ea
constant: false
boundary condition: true
is encoded by: hsa:84532
name: ACSS1
is: Q9NUB1
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252

metaM imp e
name: IMP(2-)
type: Species
boundary condition: false
constant: false
is: CHEBI:58053
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: HMDB00175
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_052a24ff_59d4_4267_8f4b_273681ee510d
is encoded by: hsa:9551
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: F8W7V3
name: ATP5J2
type: Species
initial concentration: NaN
is: SBO:0000252

metaM pail5p hs c
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57795
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
constant: false
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3

http://identifiers.org/biomodels.db/MODEL1310110054#_8f2db184_fe29_45da_916c_4c2247701c74
is: SBO:0000252
boundary condition: true
is encoded by: hsa:53354
type: Species
initial concentration: NaN
has only substance units: false
is: Q8TE04
initial amount: NaN
constant: false
name: PANK1

metaR RE2814R
product: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
reversible: true
kinetic law: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110054#
is: SBO:0000176
name: RE2814

metaR OROTGLUt
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
reversible: true
product: MODEL1310110054#
fast: false
is: SBO:0000185
type: Reaction
name: OROTGLUt

metaR FAOXC161802m
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110054#
product: MODEL1310110054#
reversible: false
fast: false
name: Beta oxidation fatty acid
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110054#
type: Reaction

metaR RAtn3
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110054#
name: 13-cis-retinoic acid transport, nuclear
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
kinetic law: MODEL1310110054#
fast: false

metaR r0340
fast: false
type: Reaction
product: MODEL1310110054#
is described by: ECO:0000000
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.3.1.38
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
kinetic law: MODEL1310110054#
is: SBO:0000176
reversible: false
reactant: MODEL1310110054#

metaR GGH 7THFe
fast: false
reversible: false
is: SBO:0000176
modifier: MODEL1310110054#
name: Gamma-glutamyl hydrolase (7THF), extracellular
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
kinetic law: MODEL1310110054#
product: MODEL1310110054#
type: Reaction

metaR HACD1m
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
fast: false
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
modifier: MODEL1310110054#
is described by: ECO:0000134

metaM retinal 11 cis c
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
has only substance units: false
name: 11-cis-retinal
is: CHEBI:16066
is: HMDB02152

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_9b893eb9_d57a_49b5_bb7f_e2ba5ee8c834
is: Q9UGH3
initial concentration: NaN
is encoded by: hsa:9962
is: SBO:0000252
has only substance units: false
constant: false
name: SLC23A2
initial amount: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_902aec8f_06f8_467c_8b3b_361a70b24162
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:79611
initial concentration: NaN
type: Species
name: ACSS3
is: Q9H6R3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_22fdf169_c8d1_4122_892f_b77579b94718
initial concentration: NaN
is: A8K761
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4716
constant: false
initial amount: NaN
name: NDUFB10
type: Species

metaR MI134P4P
is described by: ECO:0000000
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
reactant: MODEL1310110054#
name: inositol-1,3,4-trisphosphate 4-phosphatase
is: SBO:0000176
kinetic law: MODEL1310110054#
type: Reaction
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_c
boundary condition: false
is: HMDB01659
initial concentration: 1.0
is: CHEBI:15347
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0
is: SBO:0000247
name: Type IIIAb
initial amount: NaN
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_metaM_fucfucgalacglcgalacglcgal14acglcgalgluside_hs_g
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:61648
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0

metaR C226COAtx
kinetic law: MODEL1310110054#
is described by: ECO:0000000
product: MODEL1310110054#
reactant: MODEL1310110054#
reversible: true
name: fatty acid intracellular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
is: SBO:0000185

metaM succoa m
name: Succinyl-CoA
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: HMDB01022
initial concentration: 1.0
is: CHEBI:57292
boundary condition: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091

metaR EX 11 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 11-cis-retinol exchange
type: Reaction

metaM imp c
is: CHEBI:58053
has only substance units: false
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: HMDB00175
is: C00130
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
name: IMP

metaM mal L e
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
boundary condition: false
is: HMDB00156
is: CHEBI:15589
initial concentration: 1.0
name: (S)-malate(2-)
is: SBO:0000247
has only substance units: false

metaR ACACT1rm
name: acetyl-CoA C-acetyltransferase, mitochondrial
modifier: MODEL1310110054#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.9
is described by: ECO:0000000
product: MODEL1310110054#
reversible: true
fast: false

metaM acgpail hs c
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
constant: false
is: SBO:0000247
is: CHEBI:57265
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_6085e9a5_78c8_4bae_a157_81a6a92d1810
type: Species
has part: B4DER4
is encoded by: hsa:5295
name: PIK3CB:PIK3R1
has part: B3KT19
boundary condition: true
initial amount: NaN
is encoded by: hsa:5291
has only substance units: false
initial concentration: NaN
is: SBO:0000297
constant: false

metaR biomass reaction
is: SBO:0000185
reversible: false
is described by: ECO:0000134
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
name: biomass_reaction
type: Reaction

metaR SCPx
fast: false
product: MODEL1310110054#
type: Reaction
reversible: false
name: peroxisomal thiolase 2
is described by: ECO:0000269
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.3.1.176
kinetic law: MODEL1310110054#
is: SBO:0000176

metaM gdpfuc c
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: GDP-L-fucose(2-)
is: CHEBI:57984
has only substance units: false
is: HMDB01095
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
constant: false
is: SBO:0000247

metaM ksi g
name: keratan sulfate I
is: CHEBI:57255
boundary condition: false
initial amount: NaN
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
constant: false
initial concentration: 1.0
type: Species
is: HMDB01014
is: SBO:0000247
has only substance units: false

metaM hx2coa m
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892790
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
name: trans-Hex-2-enoyl-CoA

metaR DHCR243r
reversible: false
fast: false
is described by: ECO:0000134
name: 24-dehydrocholesterol reductase [Precursor]
product: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
is: SBO:0000176
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.3.1.72
type: Reaction
kinetic law: MODEL1310110054#

metaM ps hs m
has only substance units: false
is: CHEBI:18303
boundary condition: false
is: SBO:0000247
type: Species
name: ps_hs[m]
initial amount: NaN
constant: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial concentration: 1.0

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaM co c
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB01361
has only substance units: false
name: carbon monoxide
initial concentration: 1.0
is: CHEBI:17245
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
constant: false
initial amount: NaN

metaM Rtotal2 c
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: R total 2 position
has only substance units: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: HMDB01564
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:57876

metaR RE1448N
name: RE1448
type: Reaction
is: SBO:0000176
product: MODEL1310110054#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
reversible: true
reactant: MODEL1310110054#

metaM ksi deg26 l
is: CHEBI:58343
name: keratan sulfate I, degradation product 26
has only substance units: false
initial concentration: 1.0
is: HMDB00061
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: SBO:0000247

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaR CHOLESTle
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/3.1.1.13
is: SBO:0000176
name: hydrolysis of cholesterol ester by cholesterol esterase
kinetic law: MODEL1310110054#
fast: false
modifier: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
type: Reaction
product: MODEL1310110054#
reversible: false

metaM 2mb2coa m
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB02054
type: Species
has only substance units: false
constant: false
is: CHEBI:57337
name: 2-methylcrotonoyl-CoA(4-)
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
initial amount: NaN

metaR CAt7r
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (6547.6) or (6547.4) or (6547.2) or (6546.1) or (6547.1) or (6547.5) or (6543.1) or (6547.3) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12406570,PMID:2484986 NOTES:MM
is described by: ECO:0000269
modifier: MODEL1310110054#
type: Reaction
name: calcium / sodium antiporter (1:3), reversible
kinetic law: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
reversible: true
fast: false

metaR HPACtr
fast: false
product: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
reversible: true
is: SBO:0000185
name: hydroxyphenylacetate transport via diffusion
is described by: ECO:0000000
reactant: MODEL1310110054#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_95a65029_7ac0_427c_8cd4_e8ea4d33a936
name: SYNJ1
is: O43426
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:8867

metaR r2060
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
reactant: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#

metaM acnam l
initial concentration: 1.0
is: CHEBI:35418
is: HMDB00230
is: SBO:0000247
name: N-acetylneuraminate
boundary condition: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
type: Species
has only substance units: false
initial amount: NaN
constant: false

metaR GGH 10FTHF7GLUe
kinetic law: MODEL1310110054#
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
type: Reaction
product: MODEL1310110054#
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.4.19.9
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is: SBO:0000176
reversible: false
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_fe6c41d5_39f2_4013_9da3_220309d772ff
boundary condition: true
initial concentration: NaN
name: TXNRD1
type: Species
initial amount: NaN
is encoded by: hsa:7296
constant: false
has only substance units: false
is: SBO:0000252

metaR FOAXC122C101x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)x
type: Reaction

metaR r0668
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
modifier: MODEL1310110054#
type: Reaction
reversible: true
reactant: MODEL1310110054#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.2.19
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
kinetic law: MODEL1310110054#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_e
has only substance units: false
boundary condition: false
is: CHEBI:15347
initial amount: NaN
name: Type IIIAb
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
is: HMDB01659

metaR DCK2n
modifier: MODEL1310110054#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.74
is: SBO:0000176
name: Deoxycytidine kinase, nuclear (UTP)
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_19bc6dc2_b81c_4b7c_888f_f1c30040c334
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6342
is: C9JC79
boundary condition: true
has only substance units: false
type: Species
name: SCP2
constant: false
initial amount: NaN

metaR NDPK8n
type: Reaction
fast: false
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
reversible: true
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
kinetic law: MODEL1310110054#
is: SBO:0000176
modifier: MODEL1310110054#

metaR PVD3
kinetic law: MODEL1310110054#
name: Previtamin D3 formation
fast: false
product: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
reactant: MODEL1310110054#
is: SBO:0000176
type: Reaction
is described by: ECO:0000134

metaM phe L m
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: CHEBI:17295
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
name: L-phenylalanine
is: HMDB00159
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_120a3245_a778_4b4e_98ca_4dd865dc5349
initial amount: NaN
boundary condition: true
is encoded by: hsa:4128
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is: Q53YE7
has only substance units: false
name: MAOA

metaR ASCBOX
name: ascorbic acid oxidase
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
reversible: false
fast: false
reactant: MODEL1310110054#
is described by: ECO:0000000

metaR r0669
type: Reaction
kinetic law: MODEL1310110054#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
is: SBO:0000176
reversible: false
reactant: MODEL1310110054#
product: MODEL1310110054#

metaR ASCBt4
reactant: MODEL1310110054#
is described by: ECO:0000269
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
name: L-ascorbate transport via proton symport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_ff51be48_06b6_4ca7_8af0_e24931472b7a
is: SBO:0000252
constant: false
initial amount: NaN
name: FUT8
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: Q546E0
is encoded by: hsa:2530

http://identifiers.org/biomodels.db/MODEL1310110054#_bb727ab0_717d_4cb6_ba9b_610cff62db31
has only substance units: false
name: ECH1
constant: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1891
is: SBO:0000252
is: Q13011

metaR r2338
type: Reaction
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.19.1

metaM Rtotal2 e
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:3554
has only substance units: false
is: HMDB00244
notes: FORMULA: CO2FULLR2 CHARGE: -1
name: R total 2 position
is: C00255
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_67aeed81_62ca_43ae_a52d_f303aa00cf68
is encoded by: hsa:377841
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q5MY95
type: Species
name: ENTPD8
initial amount: NaN

metaR PI4P3K
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.1.154
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.153
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
is: SBO:0000176
modifier: MODEL1310110054#
name: phosphatidylinositol 4-phosphate 3-kinase
type: Reaction
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_metaM_galacglcgalacglcgal14acglcgalgluside_hs_g
name: I-antigen
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:26174
has only substance units: false
constant: false
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110054#_df0d9bd0_7230_48b3_ba7d_62fc542799c5
initial amount: NaN
is encoded by: hsa:56895
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: Q9NRZ5
name: AGPAT4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_6946a533_4529_4bce_ae48_719ad017ccbd
has only substance units: false
name: HMGCLL1
boundary condition: true
type: Species
is encoded by: hsa:54511
initial concentration: NaN
is: Q9NT06
constant: false
is: SBO:0000252
initial amount: NaN

metaM 2dodtricoa m
constant: false
has only substance units: false
name: 2,6,9-dodecatrienoylcoa
is: HMDB11123
is: C05279
is: SBO:0000247
type: Species
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR CYSSERNaEx
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000185
name: L-serine/L-cysteine Na-dependent exchange (Cys-L in)
is described by: ECO:0000269
fast: false
reactant: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
reversible: false

metaM ksi l
is: SBO:0000247
is: C00445
name: keratan sulfate I
is: HMDB01354
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
type: Species
is: CHEBI:57455
initial amount: NaN

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaR PAPStg
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
fast: false
modifier: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: true
name: 3'-Phosphoadenylyl sufate Golgi transport

http://identifiers.org/biomodels.db/MODEL1310110054#_b3d9d94b_e0de_4225_b5a1_0dea25f036ff
constant: false
name: ZADH2
is encoded by: hsa:284273
type: Species
is: Q8N4Q0
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR r0666
fast: false
is version of: http://identifiers.org/ec-code/1.2.4.2
modifier: MODEL1310110054#
is: SBO:0000176
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
reversible: true
type: Reaction
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:

metaR r0779
is described by: ECO:0000000
modifier: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
kinetic law: MODEL1310110054#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110054#_1ef97e93_87a8_49bf_b242_0a6d54c3ec63
name: ECHS1
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1892
type: Species
is: SBO:0000252
has only substance units: false
is: P30084
constant: false

metaR ACOAD8m
reactant: MODEL1310110054#
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3712.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 4 AUTHORS: PMID:9214289 NOTES:MM
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.3.99.10
modifier: MODEL1310110054#
product: MODEL1310110054#

metaR r0345
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
kinetic law: MODEL1310110054#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110054#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110054#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.13

http://identifiers.org/biomodels.db/MODEL1310110054#_89c23068_074e_49fe_8589_9cb407d0ce5a
name: DGUOK
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:1716
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_50448a38_bf64_48f9_8439_d78c85964039
constant: false
is: SBO:0000252
name: ALDH3A2
initial amount: NaN
boundary condition: true
is encoded by: hsa:224
type: Species
initial concentration: NaN
is: P51648
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_8cd086f2_fed6_45ee_90be_224c85ea38e8
is encoded by: hsa:4051
is: B7Z8Z3
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
name: CYP4F3

metaM acac m
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00060
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
type: Species
is: CHEBI:13705
name: acetoacetate
initial concentration: 1.0
initial amount: NaN

metaR DHEASULT
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.4
notes: GENE_ASSOCIATION: (6783.1) or (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:1588921 NOTES:NJ
kinetic law: MODEL1310110054#
name: Dehydroepiandrosterone sulfotransferase
is described by: ECO:0000269
reactant: MODEL1310110054#
modifier: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.14
product: MODEL1310110054#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110054#_2ed9f0f0_5998_4c4a_9a3e_54f75a9568ee
type: Species
is: SBO:0000252
initial amount: NaN
is: Q9H553
initial concentration: NaN
has only substance units: false
constant: false
name: ALG2
boundary condition: true
is encoded by: hsa:85365

metaR IDOURte
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110054#
product: MODEL1310110054#
kinetic law: MODEL1310110054#
name: L-iduronate transport, extracellular
reversible: true
type: Reaction

metaR RE3301C
reactant: MODEL1310110054#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.4
kinetic law: MODEL1310110054#
product: MODEL1310110054#
name: RE3301
modifier: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_f242de9a_7986_4d11_953a_7187ff25e36a
name: PECR
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:55825
initial amount: NaN
is: Q9BY49
type: Species

metaM fald c
is: HMDB01426
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: formaldehyde
initial concentration: 1.0
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
is: CHEBI:16842
has only substance units: false
constant: false
type: Species

metaR 4MPTNLtm
reversible: true
fast: false
reactant: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
name: 4-methylpentanal transport (mitochondria)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
is: SBO:0000185
type: Reaction

metaM dump m
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
name: dUMP(2-)
is: CHEBI:246422
has only substance units: false
is: SBO:0000247
is: HMDB01409

http://identifiers.org/biomodels.db/MODEL1310110054#_095e92e4_4b9b_4cba_a750_a105702353af
has only substance units: false
constant: false
type: Species
initial concentration: NaN
name: CHAT
boundary condition: true
is encoded by: hsa:1103
is: D3DX95
initial amount: NaN
is: SBO:0000252

metaM mi13p c
is: CHEBI:18225
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB06234
name: 1D-myo-Inositol 1,3-bisphosphate
type: Species
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-

http://identifiers.org/biomodels.db/MODEL1310110054#_acffe477_2b15_4998_9b1f_e47e23f1b4a9
boundary condition: true
is: SBO:0000252
name: ATP1A3
has only substance units: false
is encoded by: hsa:478
is: B7Z2T0
constant: false
initial amount: NaN
type: Species
initial concentration: NaN

metaM acald c
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: acetaldehyde
boundary condition: false
initial concentration: 1.0
is: HMDB00990
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: CHEBI:15343
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_e2e943fa_0b69_4eb7_948a_39ee1e424520
constant: false
name: _LOC374569_1_e
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:LOC374569
boundary condition: true
is: SBO:0000252

metaM dec47dicoa x
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
type: Species
has only substance units: false
name: 4,7-decadienoylcoa
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_g
is: CHEBI:61648
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0
type: Species
name: Type IIIAb
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_e508a172_2cc2_48db_a359_a8b3e53bf707
is encoded by: hsa:2739
has only substance units: false
boundary condition: true
initial concentration: NaN
name: GLO1
is: Q04760
type: Species
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_5db8f5d4_a4ea_4869_9049_e8bef2ac84cd
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:51166
constant: false
name: AADAT
initial amount: NaN
boundary condition: true
is: Q8N5Z0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_metaM_fucgalacgalfuc12gal14acglcgalgluside_hs_g
is: HMDB00304
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C70H122N3O40FULLRCO CHARGE: 0
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:57847
has only substance units: false
name: Type IIIH glycolipid

http://identifiers.org/biomodels.db/MODEL1310110054#_4c1bd86c_3137_472a_afdb_4ed27720f2e6
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:H45672
has only substance units: false
boundary condition: true
is: SBO:0000252
name: _H45672_1_m

http://identifiers.org/biomodels.db/MODEL1310110054#_76b85f9c_627f_4415_9865_bd721914b0dd
boundary condition: true
constant: false
is: SBO:0000252
is: P30838
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:218
has only substance units: false
name: ALDH3A1

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

metaR GALGLUSIDEtg
product: MODEL1310110054#
name: galgluside hs intracellular transport
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
fast: false
kinetic law: MODEL1310110054#
is: SBO:0000185
reversible: true

metaM nrvnc e
initial concentration: 1.0
type: Species
is: HMDB02368
is: CHEBI:32392
has only substance units: false
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
name: nervonate
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_0912b13f_7c2b_4806_a250_b273df2e7e7e
initial concentration: NaN
is encoded by: hsa:84076
is: Q9H0I9
has only substance units: false
constant: false
is: SBO:0000252
type: Species
name: TKTL2
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_a9ee6b44_80f4_411c_9044_199bc99eb5b9
name: PDE9A
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:5152
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_a9239c56_b1bd_4fe4_9e4c_8bedbdbc5ee9
initial concentration: NaN
boundary condition: true
name: _AI435857_1_x
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:AI435857
has only substance units: false

metaR PHCHGSm
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
reversible: true
reactant: MODEL1310110054#

metaM fuc1p L c
name: L-Fucose 1-phosphate
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: HMDB01265
boundary condition: false
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
is: CHEBI:28319

metaR PE HSter
name: phosphatidylethanolamine scramblase
is: SBO:0000185
kinetic law: MODEL1310110054#
reversible: true
product: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000

metaR r2333
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
product: MODEL1310110054#

metaR FAOXC12C10m
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)m
type: Reaction

metaM retinal cis 13 c
has only substance units: false
type: Species
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
initial concentration: 1.0
boundary condition: false
is: CHEBI:45487
is: HMDB06220
initial amount: NaN
name: 13-cis-retinal
constant: false
is: SBO:0000247

metaR BAMPPALDOX
is: SBO:0000176
modifier: MODEL1310110054#
reversible: false
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.36
type: Reaction
is described by: ECO:0000212
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110054#
reactant: MODEL1310110054#

metaM occoa c
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: HMDB01070
is: SBO:0000247
is: CHEBI:57386
initial amount: NaN
name: Octanoyl-CoA (n-C8:0CoA)
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: C01944
constant: false

metaR r2334
reactant: MODEL1310110054#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110054#

metaM acald e
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00990
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
boundary condition: false
name: acetaldehyde
constant: false
has only substance units: false
is: CHEBI:15343
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_5370018c_eebe_4dfa_908f_ee26b1ac56e7
constant: false
has only substance units: false
type: Species
is encoded by: hsa:AI697028
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: _AI697028_1_e

metaR r0552
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is version of: http://identifiers.org/ec-code/1.3.5.1
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
modifier: MODEL1310110054#
is: SBO:0000176
reversible: true

metaM xyl D e
constant: false
is: CHEBI:15936
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial concentration: 1.0
boundary condition: false
type: Species
name: aldehydo-D-xylose
has only substance units: false

metaM Tn antigen g
notes: FORMULA: C8H14NO5X CHARGE: 0
type: Species
name: Tn antigen
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: C04383
is: SBO:0000247

metaR NACHEX3ly
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
reversible: false
product: MODEL1310110054#
is described by: ECO:0000000

metaR FAOXC61x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)x
type: Reaction

metaR TCHOLAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
fast: false
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: bile acid intracellular transport
product: MODEL1310110054#

metaR IDOAASE4ly
is described by: ECO:0000000
is: SBO:0000176
name: alpha-L-iduronidase, lysosomal
reversible: false
modifier: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.76
fast: false

metaM btn e
boundary condition: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: SBO:0000247
is: HMDB00030
is: C00120
initial concentration: 1.0
name: Biotin
type: Species
is: CHEBI:3420
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_5dbde26c_d983_45e4_ad83_a5cbf0b3465c
initial amount: NaN
is: P35557
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
constant: false
name: GCK
is encoded by: hsa:2645

metaR PHYTt
reversible: true
name: fatty acid transport via diffusion
reactant: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110054#
is: SBO:0000185
kinetic law: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ

metaR CITtam
is: SBO:0000185
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
reversible: true
reactant: MODEL1310110054#
is described by: ECO:0000269
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
type: Reaction
fast: false
name: citrate transport, mitochondrial

metaM phe L c
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB00159
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:17295
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
name: L-phenylalanine
constant: false

metaR MAL Lte
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
name: Transport of L-malate
fast: false
reversible: true
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR S23T2g
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)
reversible: false
kinetic law: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
reactant: MODEL1310110054#
modifier: MODEL1310110054#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.4
product: MODEL1310110054#

metaM nrvnc c
is: HMDB02368
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
name: nervonate
is: CHEBI:32392
initial concentration: 1.0

metaR r2331
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR 4HPRO LTte
is: SBO:0000185
reversible: true
name: Transport of trans-4-hydroxy-L-proline
kinetic law: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
type: Reaction

metaM g2m8mpdol U r
initial concentration: 1.0
is: CHEBI:59093
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1845H3040N20O720P20 CHARGE: -20
has only substance units: false
type: Species

metaR RE2541E
product: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.31
kinetic law: MODEL1310110054#
name: RE2541
reversible: true
modifier: MODEL1310110054#

metaR EX s2l2n2m2masn LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: de-Fuc form of PA6 exchange
type: Reaction

metaM acnam n
initial amount: NaN
is: CHEBI:35418
constant: false
boundary condition: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
name: N-acetylneuraminate
initial concentration: 1.0
is: HMDB00230
type: Species
has only substance units: false
is: SBO:0000247

metaR DURIK1
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:
is described by: ECO:0000254
product: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.21
reactant: MODEL1310110054#
fast: false
is: SBO:0000176
name: deoxyuridine kinase (ATP:Deoxyuridine)
modifier: MODEL1310110054#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110054#_24143d3c_6e09_4a1c_8c4f_5beb151f31b4
is: P07864
is: SBO:0000252
constant: false
is encoded by: hsa:3948
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
name: LDHC

metaM pail5p hs n
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
type: Species
has only substance units: false
is: CHEBI:57795

metaM ps hs e
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial concentration: 1.0
name: phosphatidylserine
is: SBO:0000247
has only substance units: false
is: CHEBI:18303
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_779fbb6d_0050_464a_b716_5b3d2b7091ba
is encoded by: hsa:515
type: Species
initial concentration: NaN
has only substance units: false
constant: false
name: ATP5F1
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR IMPC
is described by: ECO:0000269
name: IMP cyclohydrolase
is version of: http://identifiers.org/ec-code/2.1.2.3
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
reversible: true
product: MODEL1310110054#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
reactant: MODEL1310110054#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_8e21ffab_75cd_4f54_abba_938be2f584b4
has only substance units: false
is: P19404
constant: false
is: SBO:0000252
initial amount: NaN
name: NDUFV2
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:4729

metaR r2332
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
fast: false
is: SBO:0000185

metaR EX galacglcgalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Gal-GlcNAc-Gal globoside (homo sapiens) exchange
type: Reaction

metaR FAS80COA L
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
product: MODEL1310110054#
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
fast: false
kinetic law: MODEL1310110054#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110054#
reactant: MODEL1310110054#

metaM btn c
has only substance units: false
type: Species
is: CHEBI:3420
initial amount: NaN
initial concentration: 1.0
name: Biotin
notes: FORMULA: C10H15N2O3S CHARGE: -1
constant: false
boundary condition: false
is: C00120
is: HMDB00030
is: SBO:0000247

metaM cdpdag hs c
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
boundary condition: false
constant: false
is: CHEBI:58332
name: CDP-diacylglycerol(2-)
initial concentration: 1.0

metaR GALt2 2
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:
reactant: MODEL1310110054#
is: SBO:0000185
modifier: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000269
kinetic law: MODEL1310110054#
name: D-galactose transport via proton symport

metaM lanost r
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
initial concentration: 1.0
name: lanosterol
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:16521
has only substance units: false
is: SBO:0000247
is: HMDB01251

metaM g3p c
is: http://identifiers.org/pubchem.compound/3930
initial concentration: 1.0
name: Glyceraldehyde 3-phosphate
type: Species
is: C00661
boundary condition: false
is: CHEBI:58027
initial amount: NaN
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
constant: false
is: HMDB01112
is: SBO:0000247
has only substance units: false

metaM 4hexdtetcoa x
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB02288
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
name: 4,7,10,13-hexadecatetraenoylcoa

metaM phe L e
is: SBO:0000247
is: HMDB00159
has only substance units: false
type: Species
is: CHEBI:17295
boundary condition: false
constant: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
initial amount: NaN
initial concentration: 1.0
name: L-phenylalanine

http://identifiers.org/biomodels.db/MODEL1310110054#_157b3c2e_36b0_4191_99dd_cb2c9f8c04b0
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:5244
boundary condition: true
initial amount: NaN
name: ABCB4
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_bb3226bc_1615_4bdb_8832_82594d383009
is encoded by: hsa:6241
has only substance units: false
is: P31350
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
name: RRM2

http://identifiers.org/biomodels.db/MODEL1310110054#_0e04a8d3_714e_4bd5_af9c_9c090231ccf6
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:284098
name: PIGW
is: Q7Z7B1
constant: false

metaM hexe3coa m
has only substance units: false
type: Species
is: SBO:0000247
name: 3-hexenoylcoa
boundary condition: false
initial amount: NaN
is: HMDB06522
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_ef0dbb54_c052_4fec_acf6_c2f6de5a25de
is: Q96AS2
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: ASAH1
boundary condition: true
is encoded by: hsa:427
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_d5aa5942_c9bf_424a_803f_2767c8109d24
is: P14060
initial concentration: NaN
constant: false
name: HSD3B1
boundary condition: true
is encoded by: hsa:3283
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN

metaR D LACt2
name: D-lactate transport via proton symport
reversible: true
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
kinetic law: MODEL1310110054#
fast: false
type: Reaction
product: MODEL1310110054#
modifier: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000185
is described by: ECO:0000269

metaM xu5p D c
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB00868
initial concentration: 1.0
has only substance units: false
name: D-xylulose 5-phosphate(2-)
constant: false
type: Species
is: CHEBI:57737
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209

metaM 2octdectecoa x
constant: false
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial concentration: 1.0
name: 2,6,9,12-octadecatetraenoylcoa
is: http://identifiers.org/pubchem.compound/5280355
initial amount: NaN
has only substance units: false

metaM CE5236 c
is: CHEBI:28002
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: HMDB03952
initial concentration: 1.0
type: Species
name: O2'-4a-cyclic-tetrahydrobiopterin

metaM ps hs c
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:18303
name: ps_hs[c]
has only substance units: false
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_38113805_1ef9_4cc4_9cee_395efb9c68d6
is: P04035
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3156
constant: false
name: HMGCR

metaM ksii core4 deg4 l
boundary condition: false
notes: FORMULA: C66H108N6O48SX CHARGE: -1
type: Species
name: keratan sulfate II (core 4-linked), degradation product 4
is: SBO:0000247
is: CHEBI:16953
initial concentration: 1.0
has only substance units: false
is: HMDB00812
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_75e1adbd_1137_4fac_8e87_c2f1e858eb03
has only substance units: false
is encoded by: hsa:6547
boundary condition: true
is: SBO:0000252
constant: false
type: Species
name: SLC8A3
initial concentration: NaN
initial amount: NaN

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_6a65f8dd_d1fc_43c5_ad23_3820dff4bd49
is: SBO:0000252
type: Species
is: Q93099
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:3081
constant: false
name: HGD

metaM hista e
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58432
boundary condition: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
type: Species
constant: false
is: HMDB00870
name: histamium
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_c7fb74a8_3454_4a2d_9a67_cebd7ef1128e
constant: false
initial amount: NaN
is encoded by: hsa:R06874
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
name: _R06874_1_r

metaM hs deg25 l
is: HMDB00127
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
initial amount: NaN
constant: false
is: CHEBI:15748
notes: FORMULA: C23H37O21 CHARGE: -1
type: Species
boundary condition: false

metaR r2330
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
is described by: ECO:0000000
reversible: true
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r0774
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
modifier: MODEL1310110054#
fast: false
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110054#

metaR CORE6GTg
name: Core 6 beta-GlcNAc-transferase A, Golgi apparatus
is: SBO:0000176
notes: GENE_ASSOCIATION: (2650.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.102
fast: false
reactant: MODEL1310110054#
reversible: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110054#
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_e5e17bcc_f7a5_4182_81eb_92f011dc0c20
initial amount: NaN
boundary condition: true
name: B3GNT6
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:192134
is: A8K9Q8

http://identifiers.org/biomodels.db/MODEL1310110054#_19a1e2ce_cadd_4d45_b118_f3287ce86e60
name: ATP5I
initial concentration: NaN
is encoded by: hsa:521
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is: P56385
has only substance units: false

metaM ksii core2 pre6 g
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
type: Species
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 6
notes: FORMULA: C61H98N5O46SX CHARGE: -2
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_819f4027_768d_49cd_ad83_2cfb51c316ca
initial concentration: NaN
is: Q9H0P0
has only substance units: false
constant: false
boundary condition: true
name: NT5C3
initial amount: NaN
is encoded by: hsa:51251
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_b4821649_9be7_4cce_ad0a_01136efeb752
constant: false
is encoded by: hsa:54
initial amount: NaN
name: ACP5
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is: P13686
boundary condition: true

metaR GLCAASE4ly
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction
name: beta-glucuronidase, lysosomal
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
reversible: false
modifier: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#

metaM air c
is: C03373
is: HMDB01235
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
has only substance units: false
type: Species
is: CHEBI:58592

metaR ACOX22x
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 2 AUTHORS: PMID:11181649 NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 analog as per KEGG added NJ
fast: false
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.99.3
is: SBO:0000176
reversible: false
name: acyl-Coenzyme A oxidase 2, branched chain

http://identifiers.org/biomodels.db/MODEL1310110054#_e584f1c2_744f_4126_bef9_86622623cc5f
name: ATP5J
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
is: P18859
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:522

metaR PPPGOm
type: Reaction
modifier: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (5498.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.4 Confidence Level: 2 AUTHORS: PMID:8771201 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.3.3.4
fast: false
name: protoporphyrinogen oxidase, mitochondrial
reactant: MODEL1310110054#
is described by: ECO:0000304
reversible: false
product: MODEL1310110054#

metaM hista c
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:58432
is: HMDB00870
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
boundary condition: false
name: histamium
is: SBO:0000247
type: Species

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_a598a960_9d60_4cca_b9cf_375e2766f894
initial concentration: NaN
has only substance units: false
is encoded by: hsa:83549
boundary condition: true
initial amount: NaN
name: UCK1
is: SBO:0000252
type: Species
is: Q5JT09
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_b691f7e1_701e_4dae_890e_38c766919331
is: SBO:0000252
initial amount: NaN
name: _286297_1_c
is encoded by: hsa:286297
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
type: Species

metaM gdpfuc g
initial concentration: 1.0
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
constant: false
initial amount: NaN
name: GDP-L-fucose(2-)
boundary condition: false
is: HMDB01095
has only substance units: false
type: Species
is: CHEBI:57984
is: SBO:0000247

metaM hs deg21 l
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: SBO:0000247
notes: FORMULA: C37H55NO38S2 CHARGE: -4
is: CHEBI:15748
is: HMDB00127
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_42eefbaa_40ad_4ede_bdb5_59460e1b0f00
name: ACP2
initial amount: NaN
constant: false
is encoded by: hsa:53
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: E9PCI1

metaM s2l2fn2m2masn e
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C90H145N6O65X CHARGE: -2
name: PA6
constant: false
is: CHEBI:3554
is: HMDB00244
initial concentration: 1.0
is: C00255

metaR O2St
is: SBO:0000185
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
fast: false
product: MODEL1310110054#
reversible: true
name: superoxide anion transport via diffusion (extracellular)
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_4db04f90_c4d6_4678_b78c_8c07edd6e1fa
is: SBO:0000252
is: P49327
is encoded by: hsa:2194
type: Species
constant: false
boundary condition: true
initial amount: NaN
name: FASN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_70d3bf75_f8e3_4c91_94f9_249e4ad988f9
is: Q9NX14
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:54539
type: Species
name: NDUFB11
initial amount: NaN
initial concentration: NaN
constant: false

metaM ksii core2 deg2 l
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 2
is: CHEBI:12936
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00143
constant: false
initial amount: NaN
type: Species

metaM HC01842 c
name: Phosphodimethylethanolamine
is: SBO:0000247
is: CHEBI:31997
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
type: Species
constant: false

metaR r1090
is described by: ECO:0000000
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
fast: false
kinetic law: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: false
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_8137ccaa_47af_42e1_8023_076cbff6f5e8
constant: false
type: Species
boundary condition: true
has only substance units: false
is: Q96PD7
initial amount: NaN
name: DGAT2
is: SBO:0000252
is encoded by: hsa:84649
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_0df01c1a_a8e6_407d_99da_5874aebdc5e8
constant: false
is: Q96KJ9
is encoded by: hsa:84701
name: COX4I2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_ad363df0_93fa_4491_905e_3a3ff0ee7c27
name: SGPL1
type: Species
initial amount: NaN
is: O95470
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:8879
has only substance units: false
is: SBO:0000252

metaM dmhptcrn c
initial concentration: 1.0
is: HMDB06320
initial amount: NaN
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
has only substance units: false
constant: false
is: SBO:0000247
type: Species
name: 2,6 dimethylheptanoyl carnitine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_72cb221c_9367_4e19_8d85_2a6bbe62e419
name: DECR2
is encoded by: hsa:26063
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: Q9NUI1
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_254ce2e5_e852_47e6_b77a_aa3aa0b08729
type: Species
is: P78542
boundary condition: true
is: SBO:0000252
name: HK1
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:3098
initial concentration: NaN

metaR EX CE5867 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acetyl-seryl-aspartyl-lysyl-proline exchange
type: Reaction

metaR FAOXC180
is: SBO:0000176
product: MODEL1310110054#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211

metaR EX glyphe LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylphenylalaine
type: Reaction

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaM cit e
initial concentration: 1.0
boundary condition: false
name: citrate(3-)
has only substance units: false
type: Species
is: HMDB00094
constant: false
is: CHEBI:16947
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: SBO:0000247

metaM 34dhoxmand m
name: 3,4-Dihydroxymandelate
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:27637
type: Species
is: SBO:0000247
is: HMDB01866

metaR ALATHRNaEx
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
name: L-alanine/L-threonine Na-dependent exchange (Ala-L in)
reactant: MODEL1310110054#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
product: MODEL1310110054#

metaR r0545
is described by: ECO:0000000
type: Reaction
product: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
is: SBO:0000176
reactant: MODEL1310110054#
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
is version of: http://identifiers.org/ec-code/3.6.1.5

metaR PI4PLCn
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.1.4.11
kinetic law: MODEL1310110054#
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110054#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
name: phosphatidylinositol 4-phosphate phospholipase C, nucleus
reactant: MODEL1310110054#

metaM his L c
constant: false
has only substance units: false
is: HMDB00177
name: L-histidine
is: SBO:0000247
is: CHEBI:15971
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133

metaR GALSIDEtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
is described by: ECO:0000000
product: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
type: Reaction
fast: false
reversible: true
name: galactocerebroside intracellular transport
kinetic law: MODEL1310110054#

metaM btcoa c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:57371
has only substance units: false
is: HMDB01088
is: C00136
constant: false
name: Butanoyl-CoA
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
type: Species
is: SBO:0000247

metaR LEUtec
fast: false
name: L-leucine transport via diffusion (extracellular to cytosol)
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reversible: true
modifier: MODEL1310110054#

metaR r0208
is described by: ECO:0000000
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/4.4.1.1
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
reactant: MODEL1310110054#
type: Reaction
reversible: true
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
fast: false
modifier: MODEL1310110054#
is: SBO:0000176

metaR C14STRr
modifier: MODEL1310110054#
name: C-14 sterol reductase
product: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#
is described by: ECO:0000134
reactant: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.70
fast: false

metaM CE1944 c
has only substance units: false
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
is: SBO:0000247
initial concentration: 1.0
name: 1-pyrrolinium
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: CHEBI:36781

metaM ksii core4 pre5 g
is: C00130
is: HMDB00175
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 5
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:58053
type: Species
notes: FORMULA: C69H112N6O48X CHARGE: -1
is: SBO:0000247

metaR RE1518M
type: Reaction
name: RE1518
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.13
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
fast: false
reactant: MODEL1310110054#

metaM c226coa c
boundary condition: false
name: cervonyl coenzyme A
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
has only substance units: false
initial concentration: 1.0
is: C16169
constant: false
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205479
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_30c67d39_0036_4356_a3ab_4a751b48565a
is: SBO:0000297
initial amount: NaN
has part: Q13733
has only substance units: false
name: ATP1A4:ATP1B1
type: Species
constant: false
is encoded by: hsa:480
boundary condition: true
initial concentration: NaN

metaR RBFK
product: MODEL1310110054#
modifier: MODEL1310110054#
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.1.26
is: SBO:0000176
fast: false
name: riboflavin kinase
reversible: false
type: Reaction
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269

metaR CAATPS
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.3.8
is: SBO:0000185
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
reversible: false
name: Ca ATPase
kinetic law: MODEL1310110054#
product: MODEL1310110054#
modifier: MODEL1310110054#
reactant: MODEL1310110054#
fast: false

metaR B3GNT311g
reversible: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
reactant: MODEL1310110054#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110054#
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110054#_ca4ae449_d84c_47be_b99b_39a019e55b54
initial concentration: NaN
is: P49888
constant: false
is encoded by: hsa:6783
is: SBO:0000252
name: SULT1E1
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true

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is: Q13946
has only substance units: false
type: Species
is encoded by: hsa:5150
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
name: PDE7A

http://identifiers.org/biomodels.db/MODEL1310110054#_dbde15b2_2531_4034_bbab_2104da247981
name: _8781_1_c
type: Species
initial amount: NaN
is encoded by: hsa:8781
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM ksii core2 deg6 l
notes: FORMULA: C44H72N4O33SX CHARGE: -1
is: SBO:0000247
type: Species
is: HMDB00143
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
name: keratan sulfate II (core 2-linked), degradation product 6
is: CHEBI:12936
initial concentration: 1.0

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_3a00d153_980c_4966_bcbf_fbe1710250cf
is: P28331
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4719
constant: false
is: SBO:0000252
has only substance units: false
name: NDUFS1

http://identifiers.org/biomodels.db/MODEL1310110054#_f982cf43_401b_403d_b011_e5c5956443df
type: Species
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: G0W2N5
initial concentration: NaN
is encoded by: hsa:6563
name: SLC14A1

metaR ACGBGBSIDEtl
product: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reactant: MODEL1310110054#
type: Reaction
fast: false
name: acgbgbside hs intracellular transport
is described by: ECO:0000000
is: SBO:0000185

metaM CE2056 r
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1/C20H32O6/c21-17(11-6-2-1-3-9-15-19(23)24)12-7-4-5-8-13-18(22)14-10-16-20(25)26/h2,4-8,12-13,17-19,21-24H,1,3,9-11,14-16H2,(H,25,26)/p-1/b5-4+,6-2-,12-7+,13-8-/t17-,18-/m0/s1 EHMN_ABBREVIATION: CE2056
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:57923
type: Species
name: 20-dihydroxyleukotriene B4

metaM so3 m
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is: SBO:0000247
is: HMDB00240
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
name: hydrogensulfite
is: CHEBI:17137

metaM hs deg19 l
initial amount: NaN
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB01352
is: SBO:0000247
constant: false
name: heparan sulfate, degradation product 19
is: CHEBI:17180

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaM dudp c
initial amount: NaN
initial concentration: 1.0
is: C01346
is: CHEBI:60471
constant: false
name: dUDP
is: SBO:0000247
is: HMDB01000
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346

http://identifiers.org/biomodels.db/MODEL1310110054#_d01d4782_afe2_47b3_ad44_4c5506ba698a
is encoded by: hsa:347734
is: SBO:0000252
has only substance units: false
boundary condition: true
name: SLC35B2
initial concentration: NaN
initial amount: NaN
is: Q8TB61
constant: false
type: Species

metaR S4TASE4ly
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reversible: true
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
type: Reaction
product: MODEL1310110054#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
modifier: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.1.6.12

metaM gthox c
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is: C00127
constant: false
is: CHEBI:58297
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB03337
boundary condition: false
has only substance units: false
name: Oxidized glutathione
initial amount: NaN

metaR GALSIDEtg
fast: false
kinetic law: MODEL1310110054#
reversible: true
product: MODEL1310110054#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
reactant: MODEL1310110054#
is described by: ECO:0000000
name: galactocerebroside intracellular transport
type: Reaction

metaM HC01496 m
initial concentration: 1.0
boundary condition: false
is: CHEBI:28095
constant: false
has only substance units: false
name: 2-Amino-3-oxoadipate
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520

http://identifiers.org/biomodels.db/MODEL1310110054#_a0c37e32_53c6_461e_a267_5d0af4d255ce
is: SBO:0000252
is encoded by: hsa:10690
initial concentration: NaN
name: FUT9
constant: false
is: Q9Y231
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species

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is: P00325
boundary condition: true
initial concentration: NaN
has only substance units: false
name: ADH1B
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:125

http://identifiers.org/biomodels.db/MODEL1310110054#_303b9084_ed9e_41f0_8689_266c90a795a6
constant: false
is encoded by: hsa:10327
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
name: AKR1A1
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_818057da_0298_498e_a92a_82a3bbbae9c1
boundary condition: true
name: GPX5
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is: O75715
is encoded by: hsa:2880
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_d6778c07_ee64_41df_9a39_a1bbf22a655a
name: ATP2B4
constant: false
has only substance units: false
is: P23634
is encoded by: hsa:493
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR ESTRADIOLtr
type: Reaction
kinetic law: MODEL1310110054#
fast: false
is described by: ECO:0000000
product: MODEL1310110054#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
reactant: MODEL1310110054#
name: estradiol intracellular transport

metaR CORE2GTg
is: SBO:0000176
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
product: MODEL1310110054#
type: Reaction
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110054#
reversible: false
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.102

http://identifiers.org/biomodels.db/MODEL1310110054#_32b93aef_f9dd_4a3b_9d93_e274f147ef43
is encoded by: hsa:6550
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: SLC9A3
initial concentration: NaN
type: Species
is: P48764
constant: false

metaM oaa c
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initial amount: NaN
is: C00036
is: HMDB00223
boundary condition: false
notes: FORMULA: C4H2O5 CHARGE: -2
is: SBO:0000247
name: Oxaloacetate
has only substance units: false
is: CHEBI:3338
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_c5dd5d10_4a80_4aa4_89db_41d5afdfe0d9
is: Q8NCI4
initial concentration: NaN
type: Species
name: PIGG
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:54872
initial amount: NaN

metaM tdcoa c
type: Species
is: HMDB01521
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
initial concentration: 1.0
is: C02593
initial amount: NaN
constant: false
is: CHEBI:57385
has only substance units: false
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: SBO:0000247
boundary condition: false

metaM 1pipdn2c x
name: 1-piperideine-2-carboxylate
initial concentration: 1.0
is: HMDB01084
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: CHEBI:16187
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092

metaR r0541
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110054#
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
product: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176

metaR EX 4mptnl LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-methylpentanal Exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_548601a5_e66f_421f_b01b_7eaf21de1a05
initial amount: NaN
name: NDUFA10
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:4705
boundary condition: true
is: O95299
type: Species

metaR CDPDAGtm
product: MODEL1310110054#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
name: intracellular transport
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000000

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_2d620836_ae30_419a_9553_0f078d67e669
is encoded by: hsa:6817
is: SBO:0000252
name: SULT1A1
has only substance units: false
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM phyt x
name: phytanate
boundary condition: false
initial amount: NaN
is: HMDB00801
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
is: CHEBI:37257

metaR UDPDOLPT U
is described by: ECO:0000000
modifier: MODEL1310110054#
product: MODEL1310110054#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.117
fast: false
reactant: MODEL1310110054#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:10359825,PMID:8280060 NOTES:NCD
kinetic law: MODEL1310110054#
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (uterus)

http://identifiers.org/biomodels.db/MODEL1310110054#_957c959d_0773_4bbb_a812_c9d7e25be483
is: P27708
is: SBO:0000252
is encoded by: hsa:790
initial amount: NaN
boundary condition: true
constant: false
name: CAD
initial concentration: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_86c8a408_364f_4c4b_8785_4be91d64d728
initial amount: NaN
has only substance units: false
is encoded by: hsa:27115
boundary condition: true
is: SBO:0000252
type: Species
name: PDE7B
constant: false
initial concentration: NaN
is: Q9NP56

http://identifiers.org/biomodels.db/MODEL1310110054#_cf907641_eae3_44ac_9503_d0866d93b70f
constant: false
has only substance units: false
name: ACO2
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is: Q99798
is encoded by: hsa:50

metaR HS2ly
name: heparan-N-sulfatase, lysosomal
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110054#
fast: false
product: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.10.1.1

http://identifiers.org/biomodels.db/MODEL1310110054#_ad02d025_aa2b_4f4f_b785_b0c6ce6f1835
is encoded by: hsa:2745
initial concentration: NaN
type: Species
is: P35754
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
name: GLRX
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_5ca8517e_862d_445a_a8ff_c71ff39c17c4
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
name: NDUFS7
is: O75251
initial concentration: NaN
constant: false
is encoded by: hsa:374291

http://identifiers.org/biomodels.db/MODEL1310110054#_052d26fa_8f44_43e2_9ff5_87d783ca2dda
is encoded by: hsa:55343
initial concentration: NaN
name: SLC35C1
initial amount: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is: B3KQH0
has only substance units: false

metaR HISD
fast: false
product: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
is: SBO:0000176
modifier: MODEL1310110054#
type: Reaction
name: histidase
reversible: false
is version of: http://identifiers.org/ec-code/4.3.1.3

metaR r0130
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
fast: false
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
modifier: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_cf31aee4_3265_4b2a_97ab_a7c6497c5ef7
name: _W74642_1_c
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:W74642
initial amount: NaN
initial concentration: NaN

metaM dmhptcrn e
initial amount: NaN
constant: false
name: 2,6 dimethylheptanoyl carnitine
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB06320
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
boundary condition: false
type: Species

metaM na1 e
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: Na CHARGE: 1
is: C01330
initial amount: NaN
is: HMDB00588
has only substance units: false
name: Sodium
boundary condition: false
initial concentration: 1.0
is: CHEBI:4541

metaM cdpdag hs m
is: CHEBI:58332
initial concentration: 1.0
name: CDP-diacylglycerol(2-)
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_db058911_bfde_49a2_bfd7_e32fc0bff1ac
has only substance units: false
is: SBO:0000252
name: NT5C
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:30833
boundary condition: true
is: Q8TCD5
initial concentration: NaN

metaR FAOXC2051843m
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110054#
is described by: ECO:0000000
product: MODEL1310110054#
modifier: MODEL1310110054#
reactant: MODEL1310110054#
reversible: false
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1

metaM his L e
boundary condition: false
constant: false
is: HMDB00177
is: CHEBI:15971
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
name: L-histidine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_2649a179_7dd7_4e54_a751_52410bf2140a
is encoded by: hsa:89874
initial amount: NaN
name: SLC25A21
is: SBO:0000252
is: G3V4L5
initial concentration: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false

metaM naglc2p U c
is: SBO:0000247
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human uterine homolog
boundary condition: false
initial amount: NaN
notes: FORMULA: C1105H1810N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:18278

metaR r1734
type: Reaction
product: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
is: SBO:0000185
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000

metaR FACOAL191
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110054#
name: fatty-acid--CoA ligase
is: SBO:0000176
modifier: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
reversible: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:11591435 NOTES:current models suggest COAL activity occurs on outer peroxisomal membrane NJ
is described by: ECO:0000269

metaM mi145p c
is: CHEBI:203600
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
is: HMDB01498
initial concentration: 1.0
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
initial amount: NaN
type: Species
has only substance units: false

metaR 5MTHFt2le
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110054#
type: Reaction
reversible: true
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000185
fast: false
is described by: ECO:0000134
name: 5-methyltetrahydrofolate transport via anion exchange

http://identifiers.org/biomodels.db/MODEL1310110054#_ff1ec3e9_ce8c_4df8_af4f_0c146a0edd22
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:3939
boundary condition: true
constant: false
name: LDHA
is: P00338
has only substance units: false
initial concentration: NaN

metaR r0202
reversible: true
is: SBO:0000176
is described by: ECO:0000000
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
kinetic law: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
reactant: MODEL1310110054#
fast: false
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_54e19391_dd17_4ef1_9935_49faa99e32ee
is: B4DDW0
type: Species
name: RDH11
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:51109

metaM 42A3HP24DB c
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
is: HMDB04083
is: http://identifiers.org/pubchem.compound/7956
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
initial amount: NaN
type: Species
is: C05645
has only substance units: false
boundary condition: false
constant: false

metaM CE5117 m
initial amount: NaN
is: CHEBI:57923
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117

metaR VALt4
product: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
name: L-valine transport in via sodium symport
fast: false
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110054#_cf19a91e_41e6_48a3_b448_7b621ef08fc4
type: Species
is encoded by: hsa:8801
name: SUCLG2:SUCLG1
has part: P53597
is encoded by: hsa:8802
has only substance units: false
initial amount: NaN
is: SBO:0000297
boundary condition: true
constant: false
initial concentration: NaN
has part: Q96I99

http://identifiers.org/biomodels.db/MODEL1310110054#_30a97ad9_12e5_451e_b059_1c74328b2013
is encoded by: hsa:197257
constant: false
has only substance units: false
is: SBO:0000252
name: LDHD
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN

metaM na1 c
constant: false
is: CHEBI:4541
name: Sodium
initial amount: NaN
is: HMDB00588
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: C01330
notes: FORMULA: Na CHARGE: 1
type: Species
boundary condition: false

metaM HC02214 c
initial concentration: 1.0
name: prostaglandin-f1alpha
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: CHEBI:28852

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_1429bf25_72e3_412c_a864_2aecdb396497
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
initial concentration: NaN
name: SDHB
is: SBO:0000252
is encoded by: hsa:6390
is: P21912

metaR CHSTEROLtrc
type: Reaction
name: transport of cholesterol into the cytosol
kinetic law: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
fast: false
reversible: true
product: MODEL1310110054#
is described by: ECO:0000134

metaR M4MPDOL Uter
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000185
name: m4mpdol flippase

metaR ALAGLYexR
is described by: ECO:0000304
name: L-alanine/glycine reversible exchange
reactant: MODEL1310110054#
is: SBO:0000185
type: Reaction
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#
fast: false

metaR TKT1
type: Reaction
is version of: http://identifiers.org/ec-code/2.2.1.1
reversible: true
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
product: MODEL1310110054#
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000176
fast: false
modifier: MODEL1310110054#
name: transketolase
is described by: ECO:0000000

metaR ACGBGBSIDEtg
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
product: MODEL1310110054#
kinetic law: MODEL1310110054#
name: acgbgbside hs intracellular transport
reactant: MODEL1310110054#
is: SBO:0000185
reversible: true
type: Reaction

metaM HC01162 c
has only substance units: false
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
boundary condition: false
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
is: SBO:0000247
type: Species
constant: false
is: CHEBI:58376
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_338eecc0_1fce_4c05_8d68_e4070137a948
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:6532
is: P31645
has only substance units: false
initial amount: NaN
name: SLC6A4

metaR NDPK7n
is described by: ECO:0000304
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
type: Reaction
fast: false
reversible: true
product: MODEL1310110054#
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
is: SBO:0000176
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_6b446605_5b03_441f_af3c_3a18e9d7d7d3
initial concentration: NaN
is: Q9BY07
constant: false
boundary condition: true
has only substance units: false
name: SLC4A5
type: Species
initial amount: NaN
is encoded by: hsa:57835
is: SBO:0000252

metaM 2maacoa m
name: 2-methylacetoacetyl-CoA(4-)
is: SBO:0000247
is: CHEBI:57335
initial concentration: 1.0
constant: false
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
is: HMDB01157
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_952ec1e7_0fd5_474d_8379_3a124e286a27
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: _AI440329_1_r
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI440329
constant: false

metaR FAOXC163x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)x
type: Reaction

metaR TKT2
is: SBO:0000176
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.2.1.1
name: transketolase
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is described by: ECO:0000000
product: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_d94dbd55_32d0_46c0_af58_86696ad8645b
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: PIK3CA
has only substance units: false
is: SBO:0000252
is: P42336
is encoded by: hsa:5290
constant: false

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaM xol27oh m
name: 26-hydroxycholesterol
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: CHEBI:17703
constant: false
has only substance units: false
is: HMDB02103
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN

metaM m6mpdol U r
is: CHEBI:37635
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C1605H2640N20O520P20 CHARGE: -20

metaR PGLer
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.47
kinetic law: MODEL1310110054#
name: 6-phosphogluconolactonase, endoplasmic reticulum
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110054#
product: MODEL1310110054#
modifier: MODEL1310110054#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD

metaM HC02214 e
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:28852
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
name: prostaglandin-f1alpha
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1

metaM for r
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
has only substance units: false
name: Formate
is: HMDB00142
is: CHEBI:15740
is: C00058
initial concentration: 1.0
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
boundary condition: false

metaR ACCOAC
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_1d794bcd_09ad_4937_8f2c_8319b2bd6fc6
constant: false
is encoded by: hsa:1327
name: COX4I1
initial amount: NaN
has only substance units: false
is: P13073
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN

metaR r1959
reversible: false
name: Y+LAT2 Utilized transport
fast: false
reactant: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185

metaR GLCNACT L
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (liver)
reactant: MODEL1310110054#
type: Reaction
fast: false
reversible: false

metaR PETOHMm hs
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
modifier: MODEL1310110054#
name: phosphatidylethanolamine N-methyltransferase
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.1.17
product: MODEL1310110054#
is described by: ECO:0000254
kinetic law: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110054#_0f337798_3ece_47d9_af08_6ab951c66bb3
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:953
name: ENTPD1
type: Species
is: Q86VV3
constant: false
is: SBO:0000252
initial amount: NaN

metaM xolest2 hs e
has only substance units: false
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:17002
name: cholesterol ester
type: Species
boundary condition: false

metaR L LACt2r
fast: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000269
reversible: true
name: L-lactate reversible transport via proton symport
is: SBO:0000185
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
reactant: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#

metaM C02470 c
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
constant: false
is: HMDB00881
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: Xanthurenic acid
is: C02470
type: Species
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/5485

http://identifiers.org/biomodels.db/MODEL1310110054#_aad1b8a3_61b0_4e36_9e01_957cdf10429c
is: P09923
is encoded by: hsa:248
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: ALPI
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_cece125c_f797_48d4_8657_615b405ee3e2
is encoded by: hsa:2879
initial concentration: NaN
has only substance units: false
type: Species
is: P36969
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: GPX4
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_48272d39_49f2_4c2a_81e8_90c5eb923144
name: _AA664770_1_m
constant: false
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AA664770

metaM 34dhoxmand c
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
name: 3,4-Dihydroxymandelate
is: SBO:0000247
is: CHEBI:27637
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB01866
initial amount: NaN
has only substance units: false

metaR ACETONEt2
type: Reaction
kinetic law: MODEL1310110054#
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000269
product: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
modifier: MODEL1310110054#
name: acetone transport via proton symport

http://identifiers.org/biomodels.db/MODEL1310110054#_b0a00e95_4e05_4f02_861e_42c58edbd57f
constant: false
is encoded by: hsa:26227
name: PHGDH
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: O43175
is: SBO:0000252
boundary condition: true

metaR FUMTSULtm
product: MODEL1310110054#
name: Fumarate:thiosulfate antiport, mitochondrial
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
modifier: MODEL1310110054#
type: Reaction
fast: false
reversible: true

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_e23d7b06_4589_4fa0_a688_b68148dc3645
initial amount: NaN
boundary condition: true
is encoded by: hsa:205
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
name: AK4

metaR r0434
fast: false
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
modifier: MODEL1310110054#
reversible: true
product: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
kinetic law: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110054#

metaR PHYCBOXL
is version of: http://identifiers.org/ec-code/4.1.1.28
reactant: MODEL1310110054#
name: L-Phenylalanine carboxy-lyase
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110054#
fast: false
type: Reaction
product: MODEL1310110054#
modifier: MODEL1310110054#
reversible: false
is: SBO:0000176
is described by: ECO:0000212

metaR 3HBCOAHLm
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
fast: false
product: MODEL1310110054#
kinetic law: MODEL1310110054#
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110054#_539e0a61_583e_4f40_9028_5830e14e927c
name: B3GALT5
has only substance units: false
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10317
initial amount: NaN

metaM arachdcoa c
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
name: arachidonoyl-CoA(4-)
is: HMDB06523
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:57368

http://identifiers.org/biomodels.db/MODEL1310110054#_e615d1f6_8812_41c9_998c_45830ff0543c
type: Species
has only substance units: false
is: SBO:0000252
is: Q3KT79
name: AMACR
is encoded by: hsa:23600
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true

metaR B3GNT11g
modifier: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: (10678.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
product: MODEL1310110054#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.1.149
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
is described by: ECO:0000269
fast: false

metaR 4MPTNLte
kinetic law: MODEL1310110054#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
type: Reaction
name: 4-methylpentanal transport
fast: false
reactant: MODEL1310110054#
is described by: ECO:0000000
product: MODEL1310110054#

metaR r1953
reactant: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#

metaR r0437
fast: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110054#
reversible: true
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/4.1.2.13
is: SBO:0000176
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
product: MODEL1310110054#
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_9f61df0f_d09f_434a_884f_002cd2910759
constant: false
is: Q15181
is: SBO:0000252
is encoded by: hsa:5464
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
name: PPA1
initial amount: NaN

metaR TRDRm
is version of: http://identifiers.org/ec-code/1.8.1.9
type: Reaction
notes: GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES:NCD
product: MODEL1310110054#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110054#
reversible: false
name: thioredoxin reductase (NADPH)
reactant: MODEL1310110054#
modifier: MODEL1310110054#
is described by: ECO:0000269

metaR r0139
is described by: ECO:0000000
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
kinetic law: MODEL1310110054#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.3.2.2
reversible: true
product: MODEL1310110054#
reactant: MODEL1310110054#
modifier: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_cae5f7a4_697b_431e_8bde_5de3ffaf7d97
boundary condition: true
name: B3GNTL1
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is: Q67FW5
is encoded by: hsa:146712
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_aa66b009_1dba_4687_9445_dd53868757d4
type: Species
is: Q92820
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8836
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: GGH

metaM m2mpdol U c
is: CHEBI:28049
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
notes: FORMULA: C1365H2240N20O320P20 CHARGE: -20
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_d988e8d3_6c1a_4197_8bb4_3653799da649
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: ALAS1
boundary condition: true
constant: false
is: P13196
is encoded by: hsa:211

metaR RE2445E
fast: false
is: SBO:0000176
modifier: MODEL1310110054#
name: RE2445
reversible: true
is described by: ECO:0000000
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (1636.1) or (59272.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.15.1 Confidence Level: 0 AUTHORS: PMID:11244003 NOTES:
is version of: http://identifiers.org/ec-code/3.4.15.1
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.4.17.23
type: Reaction
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_bc9f5821_9ef4_46b8_b734_5726221b4fc2
constant: false
is encoded by: hsa:AI971023
name: _AI971023_1_c
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true

metaR r1954
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: false

metaR GLCt4
product: MODEL1310110054#
is: SBO:0000185
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
reactant: MODEL1310110054#
reversible: true
name: glucose transport via sodium symport

metaR r0549
reversible: true
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/6.1.1.17
fast: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
reactant: MODEL1310110054#
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.6.99.3
is version of: http://identifiers.org/ec-code/1.6.5.3

metaR GCC2am
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is: SBO:0000176
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/2.1.2.10
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.8.1.4
reactant: MODEL1310110054#
reversible: true
name: glycine-cleavage complex (lipoamide), mitochondrial
fast: false
kinetic law: MODEL1310110054#

metaM 6hoxmelatn c
is: HMDB04081
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/7954
initial concentration: 1.0
is: C05643
has only substance units: false
name: 6-Hydroxymelatonin
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C13H16N2O3 CHARGE: 0 INCHI: InChI=1/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C05643

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_ef560898_e510_4ef6_8f0c_e016af66a814
is encoded by: hsa:51205
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
name: ACP6
is: Q9NPH0
boundary condition: true
initial amount: NaN

metaM CE5786 e
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:27485
has only substance units: false
is: HMDB02710
name: kinetensin
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786

metaM HC01401 m
constant: false
is: CHEBI:27668
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
type: Species
has only substance units: false
initial amount: NaN
name: (S)-3-Hydroxydodecanoyl-CoA
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR MANtg
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000185
reversible: false
fast: false
name: mannose efflux from Golgi apparatus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110054#
is described by: ECO:0000000

metaM 6a2ohxnt x
is: HMDB12151
initial amount: NaN
is: CHEBI:17534
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
name: 6-amino-2-oxohexanoic acid
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_4f7acb09_e20e_4948_b275_104a91bda89a
has only substance units: false
is encoded by: hsa:9435
is: Q9Y4C5
type: Species
name: CHST2
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR ATP2ter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110054#
reactant: MODEL1310110054#
reversible: true
name: AMP/ATP transporter, endoplasmic reticulum
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_74084f50_1b28_44ab_9d7f_f11f7ef46eab
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: O95168
is encoded by: hsa:4710
type: Species
has only substance units: false
constant: false
name: NDUFB4

metaM acnam c
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:35418
boundary condition: false
is: SBO:0000247
name: N-acetylneuraminate
is: HMDB00230
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial amount: NaN

metaM dmhptcrn m
initial amount: NaN
name: 2,6 dimethylheptanoyl carnitine
is: HMDB06320
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
type: Species
constant: false
boundary condition: false
has only substance units: false

metaM xol27oh r
boundary condition: false
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
initial concentration: 1.0
has only substance units: false
is: CHEBI:17703
initial amount: NaN
name: 26-hydroxycholesterol
is: HMDB02103
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_917cc146_be6f_4514_a6a8_025c18afaebd
is: P00374
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1719
constant: false
name: DHFR
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true

metaM malcoa r
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:57384
constant: false
is: HMDB01175
boundary condition: false
name: malonyl-CoA(4-)
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
has only substance units: false
initial concentration: 1.0

metaM dec47dicoa m
initial concentration: 1.0
has only substance units: false
name: 4,7-decadienoylcoa
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C31H46N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110054#_d67ec6c8_9559_4217_bd60_a9aeb5fd0172
initial concentration: NaN
type: Species
is: O75438
name: NDUFB1
constant: false
initial amount: NaN
is encoded by: hsa:4707
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR RE3627M
type: Reaction
modifier: MODEL1310110054#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110054#
name: RE3627
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR RE3003M
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/5.3.3.8
type: Reaction
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
name: RE3003
is described by: ECO:0000000
product: MODEL1310110054#
is: SBO:0000176
fast: false

metaR RETFA
reversible: false
is: SBO:0000176
name: retinol acyltransferase
is described by: ECO:0000000
kinetic law: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_c2743e71_0f58_4168_8834_7199abcd4ada
name: SLC4A10
is encoded by: hsa:57282
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
is: B7Z1R0
initial amount: NaN
type: Species
boundary condition: true

metaM cit c
is: CHEBI:16947
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: HMDB00094
name: Citrate
boundary condition: false
is: C00158
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial concentration: 1.0

metaM ocde9ecoa x
type: Species
initial concentration: 1.0
initial amount: NaN
name: 9-octadecenoylcoa
has only substance units: false
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110054#_4b62674e_7d06_4f1a_8d76_35d72e10f58f
is encoded by: hsa:9365
initial amount: NaN
type: Species
is: Q9UEF7
boundary condition: true
constant: false
initial concentration: NaN
name: KL
is: SBO:0000252
has only substance units: false

metaM 4ppan c
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
is: HMDB01016
boundary condition: false
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: C03492
is: SBO:0000247
is: CHEBI:10986
name: D-4'-Phosphopantothenate
initial concentration: 1.0

metaM tdcoa x
is: HMDB01521
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
type: Species
is: SBO:0000247
name: Tetradecanoyl-CoA (n-C14:0CoA)
initial concentration: 1.0
is: CHEBI:57385
boundary condition: false
initial amount: NaN
has only substance units: false
is: C02593
constant: false

metaM gpi sig r
boundary condition: false
initial concentration: 1.0
is: CHEBI:58190
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
has only substance units: false
notes: FORMULA: Y CHARGE: 0
is: HMDB00224
is: SBO:0000247
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_caf5776a_e288_489d_8d0b_927ab3e5d362
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:126
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is: P00326
name: ADH1C

http://identifiers.org/biomodels.db/MODEL1310110054#_metaM_acgalfuc12gal14acglcgalgluside_hs_g
notes: FORMULA: C58H102N3O31FULLRCO CHARGE: 0
initial amount: NaN
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
type: Species
is: HMDB00304
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57847

http://identifiers.org/biomodels.db/MODEL1310110054#_bc267679_4606_45e5_bf74_972161b27e87
is: SBO:0000252
is: B1AN63
is encoded by: hsa:64802
constant: false
boundary condition: true
has only substance units: false
name: NMNAT1
type: Species
initial amount: NaN
initial concentration: NaN

metaR DM ethamp r
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaR r2327
fast: false
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is: SBO:0000185

metaR ALADGLNexR
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-alanine/glutamine reversible exchange
type: Reaction
modifier: MODEL1310110054#
is: SBO:0000185
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_cfa84a7e_a405_4f5d_ab6a_d8904385547f
constant: false
initial concentration: NaN
is: B7Z4Y6
name: ALPL
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:249

metaR r0650
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
modifier: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110054#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is version of: http://identifiers.org/ec-code/4.1.1.36
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000176
reversible: true
fast: false

metaM HC01118 r
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
boundary condition: false
name: presqualene diphosphate(3-)
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
has only substance units: false
is: CHEBI:57310
initial amount: NaN

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaM retinal cis 9 c
initial amount: NaN
is: CHEBI:17898
type: Species
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
name: all-trans-retinal
is: HMDB01358
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM fol e
is: HMDB00121
type: Species
name: Folate
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_7e034cf3_91ce_4c22_aea2_69719c993c9a
name: FUT8
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is: B4DFS7
boundary condition: true
is encoded by: hsa:2530
has only substance units: false

metaR r0651
fast: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
kinetic law: MODEL1310110054#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
modifier: MODEL1310110054#
is: SBO:0000176
product: MODEL1310110054#

metaM CE4872 c
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
is: HMDB00127
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:15748

metaR r2328
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110054#
reactant: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#

metaM ahdt e
initial concentration: 1.0
initial amount: NaN
name: 7,8-dihydroneopterin 3'-triphosphate(4-)
is: HMDB00980
constant: false
is: CHEBI:58462
type: Species
is: SBO:0000247
notes: FORMULA: C9H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C9H16N5O13P3/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-25-29(21,22)27-30(23,24)26-28(18,19)20/h4,6,15-16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,10,11,13,14,17)/p-4/t4-,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01367 EHMN_ABBREVIATION: C04895
has only substance units: false
boundary condition: false

metaR LINKDEG2ly
name: degradation of proteoglycan linkage region, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110054#
reversible: false

metaR r0354
reversible: false
reactant: MODEL1310110054#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
kinetic law: MODEL1310110054#
product: MODEL1310110054#
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false

metaR FUT99g
modifier: MODEL1310110054#
name: Alpha-(1,3)-fucosyltransferase
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.152
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110054#_8aed8852_72aa_4b61_88ce_f4a9ebac9c84
is encoded by: hsa:3030
name: HADHA
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is: E9KL44
constant: false

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_c0c504b1_36fa_4ac6_b3e4_c2d06d0602d4
is encoded by: hsa:3073
constant: false
name: HEXA
type: Species
has only substance units: false
is: SBO:0000252
is: P06865
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaM pep c
is: C00074
initial amount: NaN
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
constant: false
initial concentration: 1.0
is: CHEBI:18021
name: Phosphoenolpyruvate
has only substance units: false
boundary condition: false
is: HMDB00263
is: SBO:0000247
type: Species

metaR r0652
kinetic law: MODEL1310110054#
reversible: true
product: MODEL1310110054#
is described by: ECO:0000000
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.5.1.2
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
fast: false
is: SBO:0000176
modifier: MODEL1310110054#
type: Reaction

metaR r2329
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110054#
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_ebabb254_4c5f_4963_9735_1a781f7688bb
is: SBO:0000252
has only substance units: false
type: Species
is: E9PB82
initial concentration: NaN
name: HSD17B4
is encoded by: hsa:3295
boundary condition: true
initial amount: NaN
constant: false

metaM ksii core2 g
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB01014
name: keratan sulfate II (core 2-linked)
is: SBO:0000247
is: CHEBI:57255
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
type: Species

metaM ksi pre10 g
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
type: Species
is: HMDB00175
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:58053
initial concentration: 1.0
is: C00130
boundary condition: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 10

http://identifiers.org/biomodels.db/MODEL1310110054#_aebcdf9b_7f11_4dcb_b38f_7c75c6c3c240
boundary condition: true
is: O00219
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:3038
initial amount: NaN
has only substance units: false
name: HAS3
is: SBO:0000252

metaM pydxn c
is: C00314
is: CHEBI:16709
is: HMDB00239
initial concentration: 1.0
name: Pyridoxine
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
type: Species

metaR r0653
fast: false
type: Reaction
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reversible: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110054#_80ce6b85_0eb1_4f79_969c_1abbb4a55379
is: Q9ULD0
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:55753
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: OGDHL

metaM pppg9 m
constant: false
is: C01079
name: Protoporphyrinogen IX
is: HMDB01097
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57307
has only substance units: false
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
is: SBO:0000247
type: Species
boundary condition: false

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaM m4masn g
boundary condition: false
initial concentration: 1.0
is: C05881
is: SBO:0000247
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C46H77N2O35X CHARGE: 0
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaM so3 c
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
type: Species
is: HMDB00240
initial amount: NaN
is: C00094
initial concentration: 1.0
name: Sulfite
boundary condition: false
is: CHEBI:17137

metaM for c
initial amount: NaN
name: Formate
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15740
type: Species
boundary condition: false
constant: false
has only substance units: false
is: C00058
is: HMDB00142

metaM ksi deg28 l
initial amount: NaN
is: CHEBI:16953
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: keratan sulfate I, degradation product 28
constant: false
notes: FORMULA: C104H170N7O85S3 CHARGE: -3
is: HMDB00812

metaM whhdca e
is: HMDB06294
boundary condition: false
constant: false
notes: FORMULA: C16H31O3 CHARGE: -1 INCHI: InChI=1/C16H32O3/c17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16(18)19/h17H,1-15H2,(H,18,19)/p-1
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: omega hydroxy hexadecanoate (n-C16:0)
initial amount: NaN
type: Species

metaR DHCHOLESTANATEtm
type: Reaction
reversible: true
fast: false
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110054#
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#

metaR AACOAT
modifier: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.16
fast: false
is: SBO:0000176
name: Acetoacetyl-CoA:acetate CoA-transferase
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
reversible: true

metaM dhap e
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
is: CHEBI:57642
is: HMDB01473
type: Species
constant: false
initial concentration: 1.0
name: glycerone phosphate(2-)
is: SBO:0000247
has only substance units: false

metaM ksii core2 e
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:17268
is: HMDB00211
constant: false
name: keratan sulfate II (core 2-linked)
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_metaM_galacglcgal14acglcgalgluside_hs_g
is: CHEBI:26174
is: SBO:0000247
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
name: i-antigen
initial amount: NaN
type: Species

metaR FAOXC164m
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_a2eaed6c_6c91_47e9_96ff_5eb7a729ba31
boundary condition: true
initial amount: NaN
is encoded by: hsa:763
name: CA5A
initial concentration: NaN
type: Species
has only substance units: false
is: P35218
constant: false
is: SBO:0000252

metaR AIRCr
product: MODEL1310110054#
modifier: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000269
kinetic law: MODEL1310110054#
name: phosphoribosylaminoimidazole carboxylase
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is version of: http://identifiers.org/ec-code/6.3.2.6
is: SBO:0000176
type: Reaction
reversible: true

metaR r2323
type: Reaction
kinetic law: MODEL1310110054#
is: SBO:0000185
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000000
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true

metaR FAOXC142C122x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)x
type: Reaction

metaR DCK1n
is described by: ECO:0000269
kinetic law: MODEL1310110054#
name: Deoxycytidine kinase, nuclear (ATP)
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.74
product: MODEL1310110054#
modifier: MODEL1310110054#
type: Reaction
reversible: true
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)

metaM c226coa x
boundary condition: false
type: Species
initial amount: NaN
name: cervonyl coenzyme A
has only substance units: false
constant: false
is: C16169
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205479
is: SBO:0000247

metaM HC01401 x
initial amount: NaN
has only substance units: false
name: (S)-3-Hydroxydodecanoyl-CoA
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
boundary condition: false
type: Species
is: CHEBI:27668

http://identifiers.org/biomodels.db/MODEL1310110054#_1ce174d9_1ba9_4ed2_9f17_b9a7fbefde10
initial amount: NaN
name: _H53099_1_m
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:H53099
constant: false
is: SBO:0000252
boundary condition: true

metaR r0655
kinetic law: MODEL1310110054#
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000176
reactant: MODEL1310110054#

metaR UMPK
is: SBO:0000176
kinetic law: MODEL1310110054#
is described by: ECO:0000269
type: Reaction
name: UMP kinase
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
product: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110054#
reversible: true

metaR S6T1g
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110054#
reactant: MODEL1310110054#
reversible: false

metaR DGAT
modifier: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
reactant: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000000
name: diacylglycerol acyltransferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.20
is: SBO:0000176
kinetic law: MODEL1310110054#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110054#_f412cac6_8cea_4ebb_8baa_c75cc461293b
is encoded by: hsa:79053
initial amount: NaN
name: ALG8
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN

metaR EX gbside hs LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: globoside (homo sapiens) exchange
type: Reaction

metaM nh4 m
initial amount: NaN
is: CHEBI:28938
initial concentration: 1.0
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
name: Ammonium
type: Species
is: C01342
constant: false
is: HMDB00051
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_06a154de_29fa_4060_a23f_287a36a494a9
type: Species
boundary condition: true
is encoded by: hsa:23236
initial concentration: NaN
name: PLCB1
is: Q9NQ66
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM nh4 n
has only substance units: false
initial amount: NaN
is: CHEBI:28938
type: Species
constant: false
boundary condition: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial concentration: 1.0
is: SBO:0000247
name: ammonium
is: HMDB00051

http://identifiers.org/biomodels.db/MODEL1310110054#_b97b4758_5045_409e_9109_55191075565e
type: Species
boundary condition: true
is: Q6P9G0
has only substance units: false
is encoded by: hsa:124637
name: CYB5D1
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR NACHEX16ly
modifier: MODEL1310110054#
reversible: false
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction

metaM formcoa x
initial concentration: 1.0
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
is: SBO:0000247
is: HMDB03419
boundary condition: false
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:57376
name: formyl-CoA(4-)

metaR EX dag hs LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for diglyceride
type: Reaction

metaM HC02175 c
is: CHEBI:27689
is: SBO:0000247
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
initial amount: NaN
boundary condition: false
constant: false
name: caprate
type: Species
has only substance units: false
initial concentration: 1.0

metaR r2324
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110054#
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR S6TASE15ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
kinetic law: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
fast: false
reactant: MODEL1310110054#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_3e72f8e4_f6fa_4aed_8353_f04527fa1ead
constant: false
is encoded by: hsa:2639
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: GCDH
type: Species
is: Q92947
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_fdaa39e3_cc89_4cff_8238_6981fec0bb26
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:R39999
has only substance units: false
initial concentration: NaN
name: _R39999_1_c

metaM for e
has only substance units: false
is: SBO:0000247
name: formate
initial concentration: 1.0
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: CHEBI:15740
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00142

metaR DM atp c
is: SBO:0000176
reversible: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110054#
product: MODEL1310110054#
name: DM_atp(c)
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_e838ca8a_36fd_4be9_aa89_3b9d02a6ca74
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:4830
initial amount: NaN
name: NME1
is: SBO:0000252
type: Species
has only substance units: false

metaM whhdca c
initial amount: NaN
name: omega hydroxy hexadecanoate (n-C16:0)
is: SBO:0000247
initial concentration: 1.0
is: HMDB06294
type: Species
boundary condition: false
constant: false
notes: FORMULA: C16H31O3 CHARGE: -1 INCHI: InChI=1/C16H32O3/c17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16(18)19/h17H,1-15H2,(H,18,19)/p-1
has only substance units: false

metaR r0355
kinetic law: MODEL1310110054#
reversible: false
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/4.2.1.3
is described by: ECO:0000000
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
product: MODEL1310110054#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1

metaR r2325
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000000
product: MODEL1310110054#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR HSPASEly
name: heparan sulfate proteoglycan protease, lysosome (endosome)
kinetic law: MODEL1310110054#
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
type: Reaction
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000000

metaR r2471
reactant: MODEL1310110054#
fast: false
reversible: false
product: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.18.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12748860 NOTES:
kinetic law: MODEL1310110054#

metaM CE2053 r
is: CHEBI:57923
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1/C20H30O5/c21-17-10-6-2-1-3-7-12-18(22)13-8-4-5-9-14-19(23)15-11-16-20(24)25/h3-5,7-9,13-14,17-19,22-23H,1-2,6,10-12,15-16H2,(H,24,25)/p-1/b5-4+,7-3-,13-8+,14-9-/t18-,19-/m1/s1 EHMN_ABBREVIATION: CE2053
type: Species
name: 20-oxo-leukotriene B4
has only substance units: false
initial amount: NaN

metaM dudp n
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:60471
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
has only substance units: false
initial concentration: 1.0
type: Species
name: dUDP(3-)
is: HMDB01000

metaR SUCOAS1m
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
fast: false
name: Succinate--CoA ligase (GDP-forming)
product: MODEL1310110054#
reversible: true
reactant: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.4

metaM dhap c
is: http://identifiers.org/pubchem.compound/3411
name: Dihydroxyacetone phosphate
initial amount: NaN
is: HMDB01473
type: Species
is: CHEBI:57642
has only substance units: false
is: C00111
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR VALTA
kinetic law: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
reversible: true
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42
type: Reaction
modifier: MODEL1310110054#
name: valine transaminase
reactant: MODEL1310110054#
fast: false

metaM fadh2 x
name: FADH2(2-)
is: CHEBI:58307
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: HMDB01197
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR FUMtm
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
fast: false
type: Reaction
kinetic law: MODEL1310110054#
name: fumarate transport, mitochondrial
reactant: MODEL1310110054#
reversible: true
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_b3e7ca40_b473_4336_bd77_f42c307cd25b
is: O75874
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
name: IDH1
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3417
type: Species

metaR r2326
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
reversible: true
product: MODEL1310110054#
fast: false

metaR EX tststerones LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: testosterone sulfate exchange
type: Reaction

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_73505182_fb11_4472_aa28_41d843d1d60f
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is: P23921
is encoded by: hsa:6240
name: RRM1
initial concentration: NaN
boundary condition: true
type: Species

metaM dhf e
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:57451
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
name: dihydrofolate(2-)
has only substance units: false
is: HMDB01056
type: Species
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_be200a4c_db15_483d_87f6_af815424ae35
type: Species
is encoded by: hsa:2222
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is: P37268
name: FDFT1

metaR LACZe
is version of: http://identifiers.org/ec-code/3.2.1.108
type: Reaction
is described by: ECO:0000134
name: b-galactosidase, extracellular
is: SBO:0000176
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase
product: MODEL1310110054#
reactant: MODEL1310110054#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110054#_877cdd5a_81b6_4278_a2fb_5cc4fabdf48f
initial concentration: NaN
is: P16278
name: GLB1
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:2720
has only substance units: false
constant: false
initial amount: NaN

metaR SFGTH
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is described by: ECO:0000269
product: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.2.12
reactant: MODEL1310110054#
fast: false
name: S-Formylglutathione hydralase
type: Reaction
reversible: true

metaM CE4876 r
boundary condition: false
has only substance units: false
is: CHEBI:57923
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
type: Species
initial concentration: 1.0
initial amount: NaN
name: delta12-Prostaglandin J2
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_b2d9d827_9d1a_4ca9_af1f_d950f54693d2
is: O75746
type: Species
initial concentration: NaN
has only substance units: false
name: SLC25A12
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:8604
is: SBO:0000252

metaM 3hpcoa m
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:58528
is: HMDB06807
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
name: 3-hydroxypropanoyl-CoA(4-)

metaM pppg9 c
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57307
initial amount: NaN
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
name: Protoporphyrinogen IX
type: Species
initial concentration: 1.0
boundary condition: false
is: C01079
is: HMDB01097

metaM dudp m
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: SBO:0000247
type: Species
has only substance units: false
name: dUDP(3-)
is: HMDB01000
constant: false
initial amount: NaN
is: CHEBI:60471

http://identifiers.org/biomodels.db/MODEL1310110054#_4f15f3ff_0d8d_4f21_819a_7574c95aed83
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
name: DGKQ
is encoded by: hsa:1609
is: P52824

metaR GLYt7 311 r
fast: false
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
is described by: ECO:0000006
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
reactant: MODEL1310110054#
reversible: true
name: glycine reversible transport via sodium and chloride symport (3:1:1)

metaM dhf c
is: HMDB01056
name: 7,8-Dihydrofolate
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: C00415
is: CHEBI:57451
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0

metaM his L m
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
type: Species
is: HMDB00177
constant: false
is: CHEBI:15971
initial amount: NaN
name: L-histidine

metaR NDP8ex
is: SBO:0000176
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.6
is described by: ECO:0000269
reactant: MODEL1310110054#
product: MODEL1310110054#
name: nucleoside-diphosphatase (UTP), extracellular
type: Reaction
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:

metaM btcoa m
is: CHEBI:57371
name: Butanoyl-CoA
boundary condition: false
initial amount: NaN
constant: false
is: C00136
type: Species
has only substance units: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
initial concentration: 1.0
is: SBO:0000247
is: HMDB01088

http://identifiers.org/biomodels.db/MODEL1310110054#_0589e2b2_ae95_4e9c_a311_e37330bcc60a
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2629
is: B7Z5G2
initial amount: NaN
type: Species
is: SBO:0000252
name: GBA

metaR r2320
kinetic law: MODEL1310110054#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110054#
product: MODEL1310110054#

metaR r2079
product: MODEL1310110054#
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000185
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_7521d7e8_3372_4ad7_a334_bee446828064
name: GAL3ST1
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is: Q99999
initial amount: NaN
is encoded by: hsa:9514
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_34180736_2ac9_4d1c_8511_07cbcbe8d5da
constant: false
is encoded by: hsa:1718
name: DHCR24
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q15392
boundary condition: true

metaR S23T3g
is version of: http://identifiers.org/ec-code/2.4.99.6
fast: false
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
modifier: MODEL1310110054#
is: SBO:0000176
reactant: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
reversible: false
kinetic law: MODEL1310110054#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110054#_c297b6df_7eeb_4a42_9bfc_0164e11edae9
initial amount: NaN
constant: false
name: PIK3CD:PIK3R1
has part: E7EX19
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5295
type: Species
has only substance units: false
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110054#_fe7ac8aa_278d_4b3f_a072_8f909d4748b3
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q9BRC7
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:84812
name: PLCD4

metaR CBR2
kinetic law: MODEL1310110054#
name: Carbonyl reductase [NADPH] 1
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.1.1.189
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110054#
reversible: false
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_7f37ff9f_8cd7_44d5_9783_6aa0859e4fa3
has only substance units: false
is: A6NFM2
boundary condition: true
is encoded by: hsa:5831
initial concentration: NaN
type: Species
initial amount: NaN
name: PYCR1
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_64eb894f_a9ac_4196_9730_17d44cac93fd
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:84693
name: MCEE
is: Q96PE7
type: Species
is: SBO:0000252
initial amount: NaN

metaR RE3002X
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.3.3.8
reactant: MODEL1310110054#
name: RE3002
kinetic law: MODEL1310110054#
product: MODEL1310110054#
fast: false
reversible: true
type: Reaction

metaR OCCOAtx
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110054#
fast: false
is: SBO:0000185
product: MODEL1310110054#
name: fatty acid intracellular transport
reactant: MODEL1310110054#

metaR r2321
fast: false
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110054#
is described by: ECO:0000000
reversible: true
product: MODEL1310110054#
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_2d7a0ffa_b5dc_45b5_8dd3_d8416b941c2a
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI291895
has only substance units: false
initial amount: NaN
constant: false
name: _AI291895_1_c
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_fb7dfb22_1951_4268_8abf_5cda2634d907
has only substance units: false
is encoded by: hsa:1103
name: CHAT
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is: P28329
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_67aaedae_d072_4748_b960_a8dec23266aa
is: Q969K7
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: TMEM54
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:113452

http://identifiers.org/biomodels.db/MODEL1310110054#_1cf407ed_b892_4d14_8889_b9e0ea0a69f9
is: P13716
is encoded by: hsa:210
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
name: ALAD
constant: false
boundary condition: true

metaM i e
name: iodide
initial concentration: 1.0
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB12238
is: CHEBI:16382

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaM tdcoa m
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: Tetradecanoyl-CoA (n-C14:0CoA)
constant: false
is: HMDB01521
type: Species
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
boundary condition: false
has only substance units: false
is: C02593
is: CHEBI:57385

http://identifiers.org/biomodels.db/MODEL1310110054#_cba75326_6391_43ed_87c5_bb1e9730d857
boundary condition: true
is encoded by: hsa:56606
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
name: SLC2A9
type: Species
initial concentration: NaN

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaR URIt
reversible: true
product: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is: SBO:0000185
fast: false
reactant: MODEL1310110054#
name: uridine facilated transport in cytosol
kinetic law: MODEL1310110054#
is described by: ECO:0000269

metaR 5ADTSTSTERONESte
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110054#
reactant: MODEL1310110054#
name: sulfonated testosterone transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
is: SBO:0000185
kinetic law: MODEL1310110054#

metaM na1 r
type: Species
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00588
has only substance units: false
is: SBO:0000247
is: CHEBI:29101
name: sodium(1+)

metaR GALASE18ly
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
reactant: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110054#
fast: false
name: beta-galactosidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110054#
type: Reaction

metaR r2322
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110054#
type: Reaction

metaM gthox m
is: HMDB03337
type: Species
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:58297
initial amount: NaN
constant: false
initial concentration: 1.0

metaR TYRTA
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110054#
name: tyrosine transaminase
modifier: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
reactant: MODEL1310110054#

metaR GLCNACT U
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (uterus)
reversible: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110054#
type: Reaction
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_9ecd33ab_ed69_4869_9542_35f18fc82259
boundary condition: true
type: Species
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:517
is encoded by: hsa:9551
initial concentration: NaN
has only substance units: false
has part: F8W7V3
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
constant: false

metaM 5dhf e
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB06487
constant: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
initial concentration: 1.0
has only substance units: false
type: Species
name: pentaglutamyl folate (DHF)

metaR NRPPHRt4 2 r
is described by: ECO:0000269
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110054#
reversible: true
is: SBO:0000185
fast: false
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
name: Norepinephrine reversible transport in via sodium symport (1:2)

metaR CYSGLTH
product: MODEL1310110054#
is: SBO:0000176
type: Reaction
name: Glutathione:cystine oxidoreductase
is described by: ECO:0000000
reactant: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM

metaM i c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
name: iodide
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB12238
is: CHEBI:16382
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_4080895d_eb1c_48c8_8c08_cf66f12ad842
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:85365
constant: false
name: ALG2
initial amount: NaN
has only substance units: false

metaM nh4 e
is: HMDB00051
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
name: ammonium
is: CHEBI:28938

metaM hgentis c
constant: false
has only substance units: false
boundary condition: false
name: homogentisate
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
type: Species
is: HMDB00130
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16169
is: SBO:0000247

metaM ksii core2 l
initial concentration: 1.0
boundary condition: false
name: keratan sulfate II (core 2-linked)
type: Species
is: SBO:0000247
is: HMDB01014
constant: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: CHEBI:57255
has only substance units: false
initial amount: NaN

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaM fol c
is: HMDB00121
initial amount: NaN
name: Folate
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial concentration: 1.0
type: Species

metaR LINOFATPtc
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

metaR THYOXt2
reactant: MODEL1310110054#
name: T4 transport via facilitated diffusion
type: Reaction
kinetic law: MODEL1310110054#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is: SBO:0000185
modifier: MODEL1310110054#
reversible: true
fast: false
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_ceb02dc3_a511_410f_a8bd_5d6f2a320d00
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:N63787
initial amount: NaN
constant: false
name: _N63787_1_c
type: Species
initial concentration: NaN

metaR DURAD
name: dihydrouracil dehydrogenase (NADP)
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
is: SBO:0000176
reversible: true
modifier: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.2
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_8891e82e_cfc0_4850_8470_b6afc4e00dad
has only substance units: false
is encoded by: hsa:3034
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
name: HAL
boundary condition: true
is: B4E0V8
constant: false

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR RE0383C
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.1.1.2
reversible: true
name: RE0383
modifier: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
product: MODEL1310110054#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110054#
fast: false

metaR KSIt
reversible: false
name: keratan sulfate I transport, golgi to extracellular
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110054#_49e34c09_3e11_42a0_9939_03f39fca44e4
initial concentration: NaN
is: Q9P109
is encoded by: hsa:51301
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
name: GCNT4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_596b0135_2fe3_43b1_9b13_fc72ca927e52
boundary condition: true
initial amount: NaN
has part: P37287
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:5277
type: Species
constant: false
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:8818
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_216ba7ce_b8cd_47de_85bb_1372143c49bb
initial concentration: NaN
is: Q13423
has only substance units: false
name: NNT
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:23530
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_6d10475f_842d_450e_8819_5db108a50734
is: SBO:0000297
constant: false
boundary condition: true
type: Species
is encoded by: hsa:3295
initial concentration: NaN
has part: E9PB82
has only substance units: false
initial amount: NaN
name: ACAA1:HSD17B4:ACOX1

http://identifiers.org/biomodels.db/MODEL1310110054#_470f982f_1132_4945_be10_101c909e6982
has only substance units: false
type: Species
is: P42765
constant: false
name: ACAA2
boundary condition: true
is encoded by: hsa:10449
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM CE4872 m
is: SBO:0000247
has only substance units: false
is: HMDB00127
initial concentration: 1.0
constant: false
is: CHEBI:15748
type: Species
initial amount: NaN
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
boundary condition: false
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872

metaM retinal cis 9 r
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: HMDB01358
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
name: all-trans-retinal
is: SBO:0000247
is: CHEBI:17898
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_f1d6c389_4b31_42d5_aaba_65aaaf17ffc8
name: AOC2
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:314
type: Species

metaR FAS120COA
modifier: MODEL1310110054#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD
fast: false
name: fatty-acyl-CoA synthase (n-C12:0CoA)
reversible: false
product: MODEL1310110054#

metaR FACOAL180i
modifier: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
name: C180 fatty acid activation
product: MODEL1310110054#
reactant: MODEL1310110054#

metaM cs e l
type: Species
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:36005
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
has only substance units: false
is: HMDB02183

http://identifiers.org/biomodels.db/MODEL1310110054#_ec5979ba_1a13_4ad9_bed5_a14fa1e36b17
initial concentration: NaN
type: Species
is encoded by: hsa:25769
has only substance units: false
name: SLC24A2
is: SBO:0000252
boundary condition: true
constant: false
is: Q9UI40
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_fcf00972_1430_4bbd_89ed_605c130bb8ac
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:125206
initial amount: NaN
name: SLC5A10
is: A0PJK1
constant: false
has only substance units: false

metaM nh4 c
has only substance units: false
boundary condition: false
is: HMDB00051
initial amount: NaN
initial concentration: 1.0
is: C01342
is: SBO:0000247
type: Species
name: Ammonium
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
constant: false
is: CHEBI:28938

http://identifiers.org/biomodels.db/MODEL1310110054#_c70275dc_bcdb_4865_9d04_bd60f0e767e4
initial amount: NaN
name: NAGK
type: Species
has only substance units: false
is: Q9UJ70
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:55577

metaR GLCNACASE1ly
modifier: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.2.1.50
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
type: Reaction
product: MODEL1310110054#
kinetic law: MODEL1310110054#
name: alpha-N-acetylglucosaminidase, lysosomal
is: SBO:0000176

metaR PDE4n
product: MODEL1310110054#
modifier: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.35
is: SBO:0000176
type: Reaction
name: 3',5'-cyclic-nucleotide phosphodiesterase, Nucleus
reversible: false
notes: GENE_ASSOCIATION: (5152.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:12565835,PMID:14527714,PMID:9624146 NOTES:NCD. IT
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000269

metaM c226coa m
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205479
is: C16169
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: SBO:0000247
boundary condition: false
name: cervonyl coenzyme A
constant: false
initial amount: NaN
has only substance units: false

metaM lnlnca c
type: Species
name: alpha-linolenate
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: CHEBI:32387
constant: false
is: HMDB01388
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_45328e3b_1508_4dce_a983_70fb00fcee4a
has part: Q9BRB3
is encoded by: hsa:5279
has part: Q92535
is encoded by: hsa:51227
has part: Q14442
has only substance units: false
is encoded by: hsa:5277
has part: O94777
initial amount: NaN
is encoded by: hsa:8818
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has part: B3KUV7
is encoded by: hsa:9091
is: SBO:0000297
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:5283

http://identifiers.org/biomodels.db/MODEL1310110054#_ca3fc828_4b2f_482f_be21_286db3a6e1db
constant: false
initial amount: NaN
is: SBO:0000252
name: AKR1A1
is encoded by: hsa:10327
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P14550

http://identifiers.org/biomodels.db/MODEL1310110054#_f7f4ae73_0c01_4728_9fa9_d84c403875ee
is: SBO:0000252
boundary condition: true
type: Species
name: ATP5L
constant: false
is: O75964
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:10632

metaR FORtr
is described by: ECO:0000000
name: FOR transporter, endoplasmic reticulum
is: SBO:0000185
kinetic law: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110054#
reactant: MODEL1310110054#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_b6eb7ddd_5834_4e67_b16b_ecdea31aa269
has only substance units: false
is: SBO:0000297
is encoded by: hsa:54344
has part: Q9P2X0
name: DPM3:DPM1:DPM2
boundary condition: true
is encoded by: hsa:8818
constant: false
type: Species
initial amount: NaN
initial concentration: NaN

metaM dhcholestancoa r
initial amount: NaN
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
boundary condition: false
type: Species
is: CHEBI:15494
constant: false
is: HMDB02159
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM g3m8mpdol L r
is: HMDB01342
boundary condition: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
notes: FORMULA: C1960H3228N20O770P20 CHARGE: -20
has only substance units: false
is: CHEBI:37568
constant: false
is: SBO:0000247
is: C00459
initial amount: NaN
type: Species
initial concentration: 1.0

metaR q10tm
fast: false
kinetic law: MODEL1310110054#
type: Reaction
is: SBO:0000185
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
reactant: MODEL1310110054#
name: transport of ubiquinone into mitochondria
reversible: true

metaM tststerones c
boundary condition: false
is: SBO:0000247
name: testosterone sulfate
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1/C19H28O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h11,14-17H,3-10H2,1-2H3,(H,21,22,23)/t14-,15-,16-,17-,18-,19-/m0/s1
type: Species
is: HMDB02833
initial concentration: 1.0

metaM cytd m
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
name: cytidine
initial amount: NaN
is: CHEBI:17562
constant: false
is: HMDB00089
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_f473b92c_d8b9_4c14_bb6f_d0d59971e776
name: PAPSS2
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:9060
is: O95340

metaM val L m
initial concentration: 1.0
boundary condition: false
type: Species
name: L-valine
is: SBO:0000247
is: CHEBI:16414
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: HMDB00883
initial amount: NaN
constant: false
has only substance units: false

metaM galside hs g
name: D-galactosyl-N-acylsphingosine
has only substance units: false
initial amount: NaN
is: CHEBI:12947
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686

metaR ALOX52
is version of: http://identifiers.org/ec-code/1.13.11.34
product: MODEL1310110054#
reactant: MODEL1310110054#
name: Arachidonate 5-lipoxygenase
type: Reaction
fast: false
modifier: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
is described by: ECO:0000269
kinetic law: MODEL1310110054#
reversible: false

metaM drib e
constant: false
is: CHEBI:28816
is: HMDB03224
name: 2-deoxy-D-ribose
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
has only substance units: false

metaR DOLPGT2 Uer
product: MODEL1310110054#
is described by: ECO:0000000
reactant: MODEL1310110054#
type: Reaction
reversible: false
is: SBO:0000176
modifier: MODEL1310110054#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
fast: false
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.1.265

metaR RE1517M
product: MODEL1310110054#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
reversible: true
is: SBO:0000176
name: RE1517
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.3.99.13
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#

metaM n2m2nmasn g
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C58H96N5O40X CHARGE: 0
type: Species
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
is: C04946
boundary condition: false

metaM 3ddecdicoa x
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
constant: false
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB03952
is: C05280
name: 3,6-dodecadienoylcoa
is: SBO:0000247
has only substance units: false

metaR S6TASE26ly
reversible: true
reactant: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
is: SBO:0000176
product: MODEL1310110054#
modifier: MODEL1310110054#

metaR r0579
is version of: http://identifiers.org/ec-code/1.13.11.19
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
product: MODEL1310110054#
is: SBO:0000176

metaR KYNAKGAT
type: Reaction
modifier: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
reversible: false
is described by: ECO:0000269
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.6.1.7
name: L-Kynurenine:2-oxoglutarate aminotransferase
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.6.1.64
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110054#_90ab4262_cbea_4b25_ad21_a39e80bdca86
is encoded by: hsa:4540
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
name: ND5
is: P03915
constant: false
initial concentration: NaN

metaM cs a deg1 l
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00812
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:16953
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
notes: FORMULA: C45H68N2O43S2 CHARGE: -4

metaM o2 m
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007
boundary condition: false
name: O2
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:15379
initial concentration: 1.0
is: HMDB01377

metaM lac L x
is: SBO:0000247
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
constant: false
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:16651
is: HMDB00190
name: (S)-lactate
initial concentration: 1.0

metaM lnlnca e
has only substance units: false
type: Species
is: SBO:0000247
name: alpha-linolenate
constant: false
is: CHEBI:32387
is: HMDB01388
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
initial amount: NaN
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_50aa3168_89a1_44da_b72c_9bc9bca2e436
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
name: PIK3R5
constant: false
is encoded by: hsa:23533
initial amount: NaN
is: Q8WYR1
initial concentration: NaN

metaR ITCOAL1m
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
reversible: true
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/6.2.1.4
fast: false
type: Reaction
product: MODEL1310110054#
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000176
is described by: ECO:0000304

metaR PI345P3P
is: SBO:0000176
kinetic law: MODEL1310110054#
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.67
reversible: false
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
product: MODEL1310110054#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110054#
type: Reaction
modifier: MODEL1310110054#

metaM tststerones e
has only substance units: false
initial amount: NaN
name: testosterone sulfate
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1/C19H28O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h11,14-17H,3-10H2,1-2H3,(H,21,22,23)/t14-,15-,16-,17-,18-,19-/m0/s1
is: SBO:0000247
constant: false
is: HMDB02833
boundary condition: false
initial concentration: 1.0
type: Species

metaM acngalgbside hs g
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:16523
constant: false
has only substance units: false
is: HMDB03406
name: sialyl galactosylgloboside
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_01bce914_beba_4bef_bb0b_3c358bea8ef2
is: P09972
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:230
boundary condition: true
initial amount: NaN
name: ALDOC

http://identifiers.org/biomodels.db/MODEL1310110054#_7ce8f825_1622_421d_b0f6_eaad03f3f992
constant: false
is: SBO:0000252
boundary condition: true
type: Species
is: Q96E98
is encoded by: hsa:6005
name: RHAG
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR r0578
is version of: http://identifiers.org/ec-code/4.1.2.27
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176
kinetic law: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110054#
product: MODEL1310110054#
modifier: MODEL1310110054#
type: Reaction
reversible: true

metaM ksi deg16 l
is: CHEBI:16953
is: HMDB00812
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 16
type: Species
notes: FORMULA: C160H258N11O137S7 CHARGE: -7
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247

metaM drib c
is: HMDB03224
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
constant: false
name: 2-deoxy-D-ribose
boundary condition: false
is: CHEBI:28816

metaM 5tedtricoa x
is: HMDB02288
has only substance units: false
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: 5,8,11-tetradecatrienoylcoa
notes: FORMULA: C35H52N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110054#_6b5df2af_87e2_4cea_abea_610031abb024
is: Q14032
initial amount: NaN
is: SBO:0000252
name: BAAT
initial concentration: NaN
is encoded by: hsa:570
type: Species
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_metaM_acglcgalacglcgal14acglcgalgluside_hs_g
has only substance units: false
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
name: (Gal)3 (Glc)1 (GlcNAc)3 (Cer)1
is: CHEBI:26174
type: Species
boundary condition: false

metaM r5p r
has only substance units: false
name: alpha-D-Ribose 5-phosphate
constant: false
is: HMDB00618
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:18189

metaM n2m2nmasn e
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C58H96N5O40X CHARGE: 0
initial amount: NaN
constant: false
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
type: Species
has only substance units: false
is: C04946
boundary condition: false

metaR FAOXC225x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_484a45f4_b04a_4d7c_8ac8_95c27aa3585f
boundary condition: true
initial concentration: NaN
constant: false
is: Q6GTM5
name: SC5DL
is encoded by: hsa:6309
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_40140051_ff5c_4206_a5c3_6c055226e11d
initial amount: NaN
is: SBO:0000252
name: PNPO
is encoded by: hsa:55163
has only substance units: false
type: Species
initial concentration: NaN
is: Q9NVS9
constant: false
boundary condition: true

metaR FAOXC226C225x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_0947b461_02d9_458c_b837_4010fd7d30a2
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: PRDX2
is encoded by: hsa:7001
is: P32119
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_69848856_c775_439b_918b_004bcc8e2e48
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
name: SLC22A3
initial amount: NaN
is encoded by: hsa:6581
is: Q5SYN6
boundary condition: true
has only substance units: false

metaR LNLCCRNt
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
product: MODEL1310110054#
name: transport into the mitochondria (carnitine)
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
reactant: MODEL1310110054#

metaM peamn c
is: CHEBI:225237
type: Species
initial concentration: 1.0
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
has only substance units: false
is: HMDB12275
constant: false
name: 2-phenylethanaminium
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaM nh4 x
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
has only substance units: false
initial concentration: 1.0
is: C01342
constant: false
initial amount: NaN
name: Ammonium
is: HMDB00051
type: Species
boundary condition: false
is: SBO:0000247

metaM ser D e
is: HMDB03406
is: CHEBI:16523
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
has only substance units: false
constant: false
name: D-serine

http://identifiers.org/biomodels.db/MODEL1310110054#_b4bf88b8_9c46_4dcb_a599_12eee30e978d
has only substance units: false
name: SLC22A1
is: O15245
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:6580
is: SBO:0000252
constant: false

metaR r2362
is: SBO:0000185
fast: false
type: Reaction
name: Organic anion transporter 5 Utilized transport
reversible: true
product: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_a8e7af13_9aa5_432c_bf73_b9686745ed12
has only substance units: false
boundary condition: true
name: SLC25A1
initial amount: NaN
is encoded by: hsa:6576
constant: false
is: D9HTE9
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_33bf71f1_4eaa_4a2c_b7f8_27c0a4c5d4ab
is: Q6FGA0
boundary condition: true
is encoded by: hsa:9167
initial concentration: NaN
initial amount: NaN
constant: false
name: COX7A2L
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_36b606e1_27ae_4402_8402_8528aceca7a3
is encoded by: hsa:427
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
name: ASAH1
is: Q13510
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_a4bc74da_2bcb_4a49_84f9_d7b3b1cb7c1e
constant: false
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
name: NDUFA11
is: C9JT23
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:126328

metaM ru5p D r
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
name: D-ribulose 5-phosphate(2-)
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:58121
initial concentration: 1.0
is: HMDB00618

metaM o2 n
constant: false
initial amount: NaN
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
has only substance units: false
is: SBO:0000247
is: HMDB01377
boundary condition: false
is: CHEBI:15379
name: dioxygen
type: Species
initial concentration: 1.0

metaM acetone m
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:15347
boundary condition: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: HMDB01659
name: acetone
type: Species
initial concentration: 1.0

metaR AKGMALtm
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
reactant: MODEL1310110054#
is: SBO:0000185
modifier: MODEL1310110054#
fast: false
reversible: true
is described by: ECO:0000269
name: alpha-ketoglutarate/malate transporter
kinetic law: MODEL1310110054#
product: MODEL1310110054#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_8f6137b2_0d36_4092_aace_10ea23610370
has only substance units: false
is encoded by: hsa:411
constant: false
type: Species
initial concentration: NaN
name: ARSB
initial amount: NaN
is: A8K4A0
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_2db70499_0fb5_4962_8007_0783fd5e20eb
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:728226
boundary condition: true
name: _728226_1_e
initial amount: NaN
constant: false

metaM galside hs c
initial concentration: 1.0
boundary condition: false
name: D-galactosyl-N-acylsphingosine
is: CHEBI:12947
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686

metaR r2361
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
product: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000185
fast: false
reversible: true

metaM ksi deg12 l
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00143
name: keratan sulfate I, degradation product 12
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:12936
is: SBO:0000247

metaM tchola c
is: HMDB00036
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:36257
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
name: taurocholic acid

metaR GNDer
name: phosphogluconate dehydrogenase, endoplasmic reticulum
fast: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
is described by: ECO:0000000
kinetic law: MODEL1310110054#
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_ca3887c2_538d_4d0c_82e0_5de9975a97a0
type: Species
is encoded by: hsa:2235
has only substance units: false
boundary condition: true
constant: false
name: FECH
is: SBO:0000252
initial concentration: NaN
is: Q7KZA3
initial amount: NaN

metaR IDPtn
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: IDP nuclear transport
reversible: true
type: Reaction
reactant: MODEL1310110054#
product: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaM spc hs c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5311445
constant: false
initial amount: NaN
name: sphingosylphosphorylcholine
has only substance units: false
type: Species
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110054#_b17dce37_27f1_49ff_b88f_6e14ac57685c
initial concentration: NaN
is encoded by: hsa:2876
type: Species
is: SBO:0000252
name: GPX1
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true

metaR r0792
type: Reaction
product: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
reactant: MODEL1310110054#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110054#
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
modifier: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_37d2e52a_dccd_45fa_83cf_6c8b7fb2e646
is: SBO:0000252
boundary condition: true
is: A0PJJ9
initial concentration: NaN
name: GGT7
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:2686
has only substance units: false

metaR r2360
is described by: ECO:0000000
reactant: MODEL1310110054#
name: Organic anion transporter 5 Utilized transport
fast: false
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM cys L c
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00574
type: Species
is: CHEBI:17561
initial concentration: 1.0
name: L-cysteine

metaM ser D c
is: CHEBI:16523
type: Species
boundary condition: false
is: HMDB03406
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
initial amount: NaN
name: D-serine
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_e6d4677e_0d13_4809_a829_0f5d3d78ba44
is encoded by: hsa:1809
initial concentration: NaN
name: DPYSL3
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is: Q8IXW6
has only substance units: false

metaR KSII CORE2tly
name: keratan sulfate II (core 2) transport, extracellular to lysosome
product: MODEL1310110054#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110054#
type: Reaction
fast: false
kinetic law: MODEL1310110054#

metaR GLYt4
type: Reaction
reversible: false
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB irreversible
product: MODEL1310110054#
name: glycine transport via sodium symport
modifier: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
is described by: ECO:0000269
is: SBO:0000185

metaR OCCOAtm
name: Octanoyl-CoA transport, diffusion
is described by: ECO:0000000
fast: false
reactant: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
reversible: false
is: SBO:0000185
product: MODEL1310110054#

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_ad7af3a5_c9a2_413f_8d54_44fa1a0dfdd8
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: ACAT2
is: Q9BWD1
is encoded by: hsa:39
initial concentration: NaN
constant: false
type: Species

metaR DOLASNT Uer
kinetic law: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: PMID:8413235,PMID:9367678 NOTES:NCD
modifier: MODEL1310110054#
is: SBO:0000176
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (uterus)
fast: false
product: MODEL1310110054#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.119
reactant: MODEL1310110054#

metaR r0791
type: Reaction
is: SBO:0000176
product: MODEL1310110054#
reversible: true
modifier: MODEL1310110054#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_9b9a17f8_3070_4ea0_a22f_854a77ac64e6
is: Q9BZV2
type: Species
is encoded by: hsa:80704
initial amount: NaN
boundary condition: true
name: SLC19A3
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_1ec2fee9_8f5e_47e4_b6e7_99132c22cf56
has only substance units: false
is: Q8IWX5
initial concentration: NaN
name: SGPP2
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:130367
boundary condition: true
initial amount: NaN

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

metaR ACETONEt2m
is: SBO:0000185
reversible: true
reactant: MODEL1310110054#
type: Reaction
name: acetone mitochondrial transport via proton symport
fast: false
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
product: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD

metaM CE2054 r
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:57923
constant: false
has only substance units: false
notes: FORMULA: C20H28O6 CHARGE: -2 INCHI: InChI=1/C20H30O6/c21-17(11-6-2-1-3-9-15-19(23)24)12-7-4-5-8-13-18(22)14-10-16-20(25)26/h2,4-8,12-13,17-18,21-22H,1,3,9-11,14-16H2,(H,23,24)(H,25,26)/p-2/b5-4+,6-2-,12-7+,13-8-/t17-,18-/m0/s1 EHMN_ABBREVIATION: CE2054
boundary condition: false
name: 20-carboxy-leukotriene-B4

metaR HSAT1ly
type: Reaction
product: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
reactant: MODEL1310110054#
is: SBO:0000185
kinetic law: MODEL1310110054#
fast: false
is described by: ECO:0000000
name: heparan-glucosaminide N-acetyltransferase, lysosomal

metaM tchola e
boundary condition: false
initial amount: NaN
notes: FORMULA: C26H45NO7S CHARGE: 0
constant: false
has only substance units: false
name: taurocholic acid
is: HMDB00036
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM cytd e
is: C00475
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
initial concentration: 1.0
type: Species
is: HMDB00089
boundary condition: false
initial amount: NaN
name: Cytidine
constant: false
is: CHEBI:17562

metaR CYSTA
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000304
reversible: true
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110054#
name: cysteine transaminase

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaR EX CE1925 LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3'-carboxy-alpha-chromanol exchange
type: Reaction

metaM CE4793 x
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:57923
boundary condition: false
initial amount: NaN
name: 3-oxo-dihomo-gama-linolenoyl-CoA
notes: FORMULA: C41H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29(49)24-32(51)70-23-22-43-31(50)20-21-44-39(54)36(53)41(2,3)26-63-69(60,61)66-68(58,59)62-25-30-35(65-67(55,56)57)34(52)40(64-30)48-28-47-33-37(42)45-27-46-38(33)48/h8-9,11-12,14-15,27-28,30,34-36,40,52-53H,4-7,10,13,16-26H2,1-3H3,(H,43,50)(H,44,54)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/b9-8-,12-11-,15-14-/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4793
is: SBO:0000247
constant: false

metaM cys L e
initial concentration: 1.0
is: SBO:0000247
name: L-cysteine
initial amount: NaN
is: HMDB00574
has only substance units: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
constant: false
boundary condition: false
is: CHEBI:17561
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_6238b0e0_b22e_45e3_b58b_c56e5ff20136
constant: false
is encoded by: hsa:222
has only substance units: false
is: P48448
type: Species
name: ALDH3B2
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR FUMSO3tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
modifier: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#
name: Fumarate:sulfite antiport, mitochondrial
reversible: true
is described by: ECO:0000269
fast: false
product: MODEL1310110054#
is: SBO:0000185
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_6719e49d_5576_422e_9147_d5f1e4c3e008
is: SBO:0000252
initial concentration: NaN
name: PDE9A
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:5152
boundary condition: true
constant: false

metaR OCDCAtr
is described by: ECO:0000000
kinetic law: MODEL1310110054#
fast: false
name: fatty acid transport via diffusion
reversible: true
product: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaR SERGLYexR
kinetic law: MODEL1310110054#
is: SBO:0000185
name: L-Serine/Glycine reversible exchange
reversible: true
modifier: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
fast: false
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110054#_972f701a_2429_4f9b_b1eb_3a223cb3d653
type: Species
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is: A8K761
name: NDUFB10
has only substance units: false
is encoded by: hsa:4716

metaR CYTK7n
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110054#
modifier: MODEL1310110054#
reversible: true
kinetic law: MODEL1310110054#
name: cytidylate kinase (CMP,UTP),nuclear
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_0a2be77f_9329_423a_bf38_578f8c972a81
name: SLC5A12
is encoded by: hsa:159963
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q1EHB4
has only substance units: false
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_70ed4871_6616_4899_a047_d7a51b0c37fe
is encoded by: hsa:1606
is: SBO:0000252
is: P23743
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
name: DGKA
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_fe4ab26f_d35a_4183_a5c3_7c0a7aa18338
is encoded by: hsa:509
is: Q6I9V2
name: ATP5C1
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM HC01603 c
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
is: C00234
has only substance units: false
is: CHEBI:57454
name: 10-Formyltetrahydrofolate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_f4af8599_b134_40fb_94d2_03cd56b1b66b
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: P00390
has only substance units: false
is: SBO:0000252
name: GSR
is encoded by: hsa:2936

http://identifiers.org/biomodels.db/MODEL1310110054#_746edb7b_31d8_4016_ad0e_81d850c07243
boundary condition: true
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q9ULD0
name: OGDHL
is encoded by: hsa:55753
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_50d0b8d5_d346_43f5_8fb7_44e23a256d4e
boundary condition: true
is: SBO:0000252
name: NDUFB6
constant: false
is: O95139
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:4712

metaR r0426
kinetic law: MODEL1310110054#
product: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.34
reversible: true
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
reactant: MODEL1310110054#
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

metaM lnlnca l
name: alpha-linolenate
constant: false
is: CHEBI:32387
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
is: SBO:0000247
initial amount: NaN
is: HMDB01388
has only substance units: false
type: Species

metaR TSTSTERONESULT
is described by: ECO:0000269
name: testosterone sulfotransferase
modifier: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (6822.1) or (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES:NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.14

metaR GLUDxm
reactant: MODEL1310110054#
name: glutamate dehydrogenase (NAD) (mitochondrial)
reversible: true
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.4.1.3

metaR ACACT7p
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
type: Reaction
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110054#
reactant: MODEL1310110054#
reversible: false
is described by: ECO:0000269
fast: false
is: SBO:0000176
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#

metaM o2 r
boundary condition: false
name: O2
is: CHEBI:15379
is: SBO:0000247
has only substance units: false
is: HMDB01377
initial amount: NaN
initial concentration: 1.0
is: C00007
type: Species
constant: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007

http://identifiers.org/biomodels.db/MODEL1310110054#_5fa40367_fc64_4104_9655_086ab4597c06
is: Q9NXB9
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
name: ELOVL2
constant: false
is encoded by: hsa:54898
initial amount: NaN
is: SBO:0000252

metaR RPE
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/5.1.3.1
is described by: ECO:0000000
modifier: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
is: SBO:0000176
type: Reaction
name: ribulose 5-phosphate 3-epimerase
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_a17afee9_9310_4475_b2e4_9acd5d85d05d
name: LPGAT1
type: Species
initial amount: NaN
is: Q92604
constant: false
is encoded by: hsa:9926
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_a5d43dbe_3418_4c5c_92a3_e546e5f3e338
is: SBO:0000252
initial concentration: NaN
is: Q9BV79
is encoded by: hsa:51102
type: Species
boundary condition: true
constant: false
initial amount: NaN
name: MECR
has only substance units: false

metaR NDP7ex
name: nucleoside-diphosphatase (UDP), extracellular
is version of: http://identifiers.org/ec-code/3.6.1.6
is: SBO:0000176
type: Reaction
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
is described by: ECO:0000269
reversible: false
product: MODEL1310110054#
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false

metaR MTHFD2
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
is described by: ECO:0000134
reactant: MODEL1310110054#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false
kinetic law: MODEL1310110054#
name: methylenetetrahydrofolate dehydrogenase (NAD)
product: MODEL1310110054#
modifier: MODEL1310110054#
reversible: true

metaM leuktrA4 e
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB01337
has only substance units: false
is: CHEBI:57463
name: leukotriene A4(1-)
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
initial amount: NaN
initial concentration: 1.0

metaM ksi pre14 g
boundary condition: false
type: Species
name: keratan sulfate I biosynthesis, precursor 14
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:28067

http://identifiers.org/biomodels.db/MODEL1310110054#_25a4bfcc_cb4f_4810_8f0b_39e231d219c5
has part: B7Z9T9
is: SBO:0000297
has part: Q13956
is encoded by: hsa:5158
is encoded by: hsa:5149
is encoded by: hsa:5145
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: PDE6A:PDE6H:PDE6B
has part: P16499
constant: false
boundary condition: true
type: Species

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaM cytd c
has only substance units: false
is: C00475
constant: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: CHEBI:17562
is: SBO:0000247
initial concentration: 1.0
type: Species
name: Cytidine
boundary condition: false
is: HMDB00089
initial amount: NaN

metaM n2m2nmasn l
initial amount: NaN
initial concentration: 1.0
is: C04946
notes: FORMULA: C58H96N5O40X CHARGE: 0
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
constant: false
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR GTHPm
reversible: true
reactant: MODEL1310110054#
product: MODEL1310110054#
name: glutathione peroxidase, mitochondria
type: Reaction
fast: false
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
is version of: http://identifiers.org/ec-code/1.11.1.12
is version of: http://identifiers.org/ec-code/1.11.1.15

metaR DUDPtn
is described by: ECO:0000000
product: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: true
name: dUDP nuclear transport
fast: false
is: SBO:0000185
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_4a7a07e1_abc3_47bb_b52e_99c3571e244e
is: O75489
is encoded by: hsa:4722
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
name: NDUFS3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_7fd0e591_29f0_4ff3_9d01_15822d3c10d0
type: Species
constant: false
name: CPT1B
has only substance units: false
is: Q92523
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1375
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_40634a46_b53e_4598_be0d_694239f1071e
has only substance units: false
initial concentration: NaN
is: Q9P2X0
name: DPM3
constant: false
is encoded by: hsa:54344
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaR EX galgalgalthcrm hs LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_6de49bf9_7113_4fe5_a547_53293ca6a9ec
is: SBO:0000252
name: ATP5A1
boundary condition: true
initial concentration: NaN
is encoded by: hsa:498
constant: false
type: Species
is: A8K092
initial amount: NaN
has only substance units: false

metaM strdnc e
initial amount: NaN
initial concentration: 1.0
is: HMDB06547
is: SBO:0000247
name: stearidonic acid C18:4, n-3
is: http://identifiers.org/pubchem.compound/47205608
boundary condition: false
type: Species
has only substance units: false
is: C16300
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_28091fbe_fabb_4ec5_8ce2_b3a6ddc21738
is encoded by: hsa:5332
is: SBO:0000252
initial concentration: NaN
is: E2QRH8
has only substance units: false
boundary condition: true
name: PLCB4
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_7542d397_a17e_42a8_ae85_8f32095e3083
constant: false
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:5279
initial concentration: NaN
is: SBO:0000252
name: PIGC

metaM 4nph c
type: Species
constant: false
name: 4-nitrophenolate
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB01232
is: CHEBI:57917
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
initial amount: NaN
is: SBO:0000247

metaR r0424
is described by: ECO:0000000
reversible: true
fast: false
modifier: MODEL1310110054#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.17.1.4
type: Reaction
product: MODEL1310110054#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110054#_541d1bdd_0610_4ea1_9460_f9bc9fe72b49
is: SBO:0000252
boundary condition: true
name: PLCB2
initial concentration: NaN
is encoded by: hsa:5330
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: Q59F77

metaR MG2er
reversible: false
type: Reaction
reactant: MODEL1310110054#
is described by: ECO:0000000
fast: false
product: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_c55fa2a2_b4dd_4d36_8353_46582ff3b27a
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
name: PRDX3
is encoded by: hsa:10935
initial amount: NaN
constant: false
is: E9PH29
is: SBO:0000252

metaR OMPDC
reactant: MODEL1310110054#
is described by: ECO:0000269
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.2.10
reversible: false
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
fast: false
modifier: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#
name: orotidine-5'-phosphate decarboxylase
type: Reaction

metaM spc hs e
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
has only substance units: false
name: sphingosylphosphorylcholine
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5311445
initial amount: NaN

metaM o2 x
constant: false
is: CHEBI:15379
is: C00007
initial concentration: 1.0
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
name: O2
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species

metaR B3GNT51g
type: Reaction
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (84002.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
is described by: ECO:0000304
modifier: MODEL1310110054#
is: SBO:0000176
reversible: false
fast: false

metaR r0423
fast: false
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reactant: MODEL1310110054#
reversible: true
modifier: MODEL1310110054#
type: Reaction
is: SBO:0000176
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110054#

metaR HDDACBP
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM ksi deg32 l
initial amount: NaN
type: Species
is: HMDB00143
is: CHEBI:12936
boundary condition: false
is: SBO:0000247
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
has only substance units: false
name: keratan sulfate I, degradation product 32
constant: false
initial concentration: 1.0

metaR LEUPHELAT2tc
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM thp2c c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB12130
is: CHEBI:16987
is: SBO:0000247
type: Species
name: 1-piperideine-6-carboxylate
boundary condition: false
constant: false
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450

metaM strdnc c
has only substance units: false
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: C16300
is: HMDB06547
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205608
type: Species
name: stearidonic acid C18:4, n-3
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR FATP8t
reactant: MODEL1310110054#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
type: Reaction
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/6.2.1.7
is: SBO:0000185
fast: false
name: fatty acid electroneutral transport
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaR TMDPK
product: MODEL1310110054#
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.6.2
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_d1cb5e6e_6422_4451_bf0d_a0d9c140fb8c
is: Q8NBL9
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:94005
has only substance units: false
name: PIGS
boundary condition: true
type: Species
initial concentration: NaN

metaM HC01231 m
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58480
boundary condition: false
name: N-[(R)-pantothenoyl]-L-cysteinate
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
has only substance units: false
type: Species

metaM 4nph e
name: 4-nitrophenolate
is: CHEBI:57917
has only substance units: false
initial amount: NaN
is: HMDB01232
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR r0422
is described by: ECO:0000000
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reversible: true
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
reactant: MODEL1310110054#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3

metaR GHMT2r
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.1.2.1
name: glycine hydroxymethyltransferase, reversible
fast: false
is: SBO:0000176
product: MODEL1310110054#
reversible: true
reactant: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_e6ac0587_66d1_4a25_ac3a_74ba170e8d27
type: Species
is: P55809
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5019
name: OXCT1

metaR r1924
is: SBO:0000185
reactant: MODEL1310110054#
fast: false
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110054#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110054#
product: MODEL1310110054#

metaR NDPK6n
reversible: true
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
is described by: ECO:0000304
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
type: Reaction
fast: false
modifier: MODEL1310110054#
product: MODEL1310110054#

metaM dcacoa x
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
name: Decanoyl-CoA (n-C10:0CoA)
has only substance units: false
is: HMDB06404
boundary condition: false
is: CHEBI:61430
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: C05274
is: SBO:0000247

metaM acetone e
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: acetone
is: CHEBI:15347
is: HMDB01659
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207

metaM 4fumacac c
is: SBO:0000247
is: HMDB01268
constant: false
boundary condition: false
is: CHEBI:18034
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
name: 4-fumarylacetoacetate(2-)
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_388dc2df_bb8b_4aa0_8936_531149aa88f9
is: P21399
name: ACO1
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:48
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN

metaR 10FTHFtm
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
product: MODEL1310110054#
fast: false
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#

metaR RPI
is described by: ECO:0000000
reactant: MODEL1310110054#
modifier: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
is: SBO:0000176
name: ribose-5-phosphate isomerase
type: Reaction
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/5.3.1.6
reversible: true
kinetic law: MODEL1310110054#

metaM g3m8mpdol U r
type: Species
initial concentration: 1.0
notes: FORMULA: C1905H3140N20O770P20 CHARGE: -20
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
is: C05873
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaR 2OXOADPTm
name: 2-oxoadipate shuttle (cytosol/mitochondria)
fast: false
modifier: MODEL1310110054#
is described by: ECO:0000269
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877

metaR FAH3
product: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: false
is version of: http://identifiers.org/ec-code/1.14.15.3
type: Reaction
name: Fatty acid omega-hydroxylase
modifier: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (1579.1) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11996015,PMID:7679927,PMID:8274222 NOTES:fatty acid omega hydroxylation NJ
is described by: ECO:0000269
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110054#_6a333826_ba22_4d21_894d_77e1ef77ad59
boundary condition: true
name: CHST4
type: Species
initial concentration: NaN
is encoded by: hsa:10164
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q8NCG5
constant: false

metaR RE2349C
is: SBO:0000176
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
is version of: http://identifiers.org/ec-code/2.6.1.64
is described by: ECO:0000000
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: true
fast: false
type: Reaction
name: RE2349
modifier: MODEL1310110054#
product: MODEL1310110054#

metaR DOLPMT2 Uer
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110054#
kinetic law: MODEL1310110054#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is: SBO:0000176
reactant: MODEL1310110054#

metaR S2TASE1ly
name: iduronate-2-sulfatase, lysosomal
is: SBO:0000176
product: MODEL1310110054#
modifier: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
reversible: false
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.13

metaR r1921
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
product: MODEL1310110054#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110054#
reversible: false
modifier: MODEL1310110054#
fast: false

metaM ksi pre25 g
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
name: keratan sulfate I biosynthesis, precursor 25
is: CHEBI:58053
is: SBO:0000247
has only substance units: false
is: HMDB00175
is: C00130
type: Species
constant: false

metaM formcoa c
boundary condition: false
constant: false
is: HMDB03419
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:57376
is: SBO:0000247
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
name: formyl-CoA(4-)
initial concentration: 1.0

metaR FACOAL184
reactant: MODEL1310110054#
name: fatty-acid--CoA ligase
is described by: ECO:0000000
type: Reaction
product: MODEL1310110054#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3

metaM HC02216 e
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
name: prostaglandin-f2beta
type: Species
is: CHEBI:28922
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_f87aaed3_bd10_461e_a6ca_fbb406eb98cd
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:10400
initial concentration: NaN
type: Species
constant: false
has only substance units: false
name: PEMT

metaR NDPK6m
type: Reaction
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
fast: false
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is described by: ECO:0000254
product: MODEL1310110054#
is: SBO:0000176

metaM pail35p hs c
type: Species
constant: false
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
is: CHEBI:57923
boundary condition: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_a8538bc9_f08b_4795_a4fb_79d0548a3b34
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false
name: SLC7A8
is encoded by: hsa:23428
is: Q9UHI5
boundary condition: true

metaM dhcholestancoa x
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
has only substance units: false
is: HMDB02159
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
boundary condition: false
is: CHEBI:15494
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110054#_1c089963_5573_42a5_8798_568f88c5f882
boundary condition: true
type: Species
name: SLC29A2
is: Q14542
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:3177

metaM galside hs l
constant: false
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial concentration: 1.0
type: Species
name: D-galactosyl-N-acylsphingosine
boundary condition: false
is: CHEBI:12947
is: SBO:0000247
has only substance units: false

metaR MI13PP
product: MODEL1310110054#
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
type: Reaction
name: inositol-1,3-bisphosphate 3-phosphatase
is: SBO:0000176
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_d9ed7fd7_d49b_4b76_9534_1d6521d328c4
has part: P23921
initial amount: NaN
has part: P31350
initial concentration: NaN
constant: false
is encoded by: hsa:6240
type: Species
is: SBO:0000297
boundary condition: true
is encoded by: hsa:6241
name: RRM1:RRM2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_c6b80e15_484e_4244_aad4_5502a1ddd6a7
is encoded by: hsa:10637
name: LEFTY1
is: O75610
boundary condition: true
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM cala c
initial amount: NaN
name: N-carbamoyl-beta-alaninate
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
is: CHEBI:11892
is: HMDB00026
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110054#_metaM_acglc13galacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:26174
boundary condition: false
type: Species
has only substance units: false
name: nLc7Cer
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110054#_0e75ce20_fe78_4938_99e1_248c68844c18
is: SBO:0000252
constant: false
has only substance units: false
is: P49902
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:22978
boundary condition: true
name: NT5C2

metaM ficytC m
constant: false
name: Ferricytochrome c
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:15991
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
boundary condition: false

metaM leuktrA4 c
type: Species
is: HMDB01337
boundary condition: false
is: CHEBI:57463
name: leukotriene A4(1-)
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
constant: false
initial amount: NaN

metaR RE3628M
reactant: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/5.3.3.8
is described by: ECO:0000000
name: RE3628
reversible: true
product: MODEL1310110054#
fast: false
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110054#_9978cfac_fbad_449e_93c2_0b154bcf1022
initial amount: NaN
boundary condition: true
name: NDUFB5
is: O43674
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:4711
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_1c4bbd30_414b_4260_8fb4_ccf5d07e8d1e
is: SBO:0000252
name: OXSM
is: Q9NWU1
is encoded by: hsa:54995
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
constant: false

metaR GLYOX
is: SBO:0000176
name: hydroxyacylglutathione hydrolase
modifier: MODEL1310110054#
reversible: false
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3029.1) or (84264.2) or (84264.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.6 Confidence Level: 4 AUTHORS: PMID:15117945,PMID:8550579 NOTES:IF
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.1.2.6
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#

metaM acgam6p c
is: HMDB01062
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
name: N-acetyl-D-glucosamine 6-phosphate(2-)
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57513

http://identifiers.org/biomodels.db/MODEL1310110054#_ca40ce8e_99fc_4a05_8238_4afead057d92
is encoded by: hsa:AI971036
name: _AI971036_1_m
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_90e6b6a9_3d6b_49d5_a1c0_725212cd190a
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:11041
initial concentration: NaN
constant: false
boundary condition: true
name: B3GNT1
is: O43505
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_17bbb828_5f6d_42aa_828c_e5b9adc22044
has only substance units: false
boundary condition: true
is encoded by: hsa:8654
constant: false
type: Species
is: G5E9C5
is: SBO:0000252
name: PDE5A
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_cdc1d9d2_2180_4bfb_9cdd_f4f26ee95ada
initial concentration: NaN
has part: B7Z2T0
has part: A3KLL5
type: Species
is: SBO:0000297
name: ATP1A3:ATP1B1
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:478
is encoded by: hsa:481

http://identifiers.org/biomodels.db/MODEL1310110054#_2bf2186b_e7ba_4154_8f2e_30cd26638da3
boundary condition: true
constant: false
name: SLC35D1
initial concentration: NaN
type: Species
is: Q9NTN3
initial amount: NaN
is encoded by: hsa:23169
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_29aea073_08a5_4238_9ac1_8b412fd628a2
type: Species
is encoded by: hsa:5096
is: SBO:0000297
initial amount: NaN
has only substance units: false
is encoded by: hsa:5095
constant: false
boundary condition: true
name: PCCA:PCCB
initial concentration: NaN
has part: C9JPQ8
has part: P05166

http://identifiers.org/biomodels.db/MODEL1310110054#_cd911ec7_cf64_4771_a876_396aacd41576
boundary condition: true
has only substance units: false
constant: false
is: O15305
initial amount: NaN
type: Species
name: PMM2
initial concentration: NaN
is encoded by: hsa:5373
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_9c800c8e_79a0_42ca_b021_b261ad6ae9b1
initial concentration: NaN
is encoded by: hsa:956
is: SBO:0000252
is: O75355
has only substance units: false
name: ENTPD3
initial amount: NaN
boundary condition: true
type: Species
constant: false

metaR r0644
kinetic law: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
fast: false
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
type: Reaction
product: MODEL1310110054#
is: SBO:0000176
reactant: MODEL1310110054#
reversible: true

metaR r2200
modifier: MODEL1310110054#
type: Reaction
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110054#
is described by: ECO:0000000
kinetic law: MODEL1310110054#
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5

metaR SPODMx
product: MODEL1310110054#
reversible: false
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
is: SBO:0000176
name: superoxide dismutase, peroxisome
reactant: MODEL1310110054#
type: Reaction
fast: false
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.15.1.1

metaR r2084
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110054#
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#

metaM ribflv e
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C17H20N4O6 CHARGE: 0
boundary condition: false
constant: false
is: CHEBI:3554
initial amount: NaN
is: HMDB00244
name: Riboflavin
is: C00255
initial concentration: 1.0

metaM leuktrE4 c
is: CHEBI:57462
is: SBO:0000247
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
has only substance units: false
initial amount: NaN
is: HMDB02200
boundary condition: false
constant: false
initial concentration: 1.0
name: leukotriene E4(1-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110054#_b811109c_1296_494a_aac6_2c7456840094
initial concentration: NaN
name: _AA788780_1_c
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:AA788780
constant: false
is: SBO:0000252

metaM ksii core4 pre6 g
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 6
initial concentration: 1.0
notes: FORMULA: C69H111N6O51SX CHARGE: -2
type: Species
is: CHEBI:28067
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR r1915
product: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110054#
is: SBO:0000185
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110054#
name: Y+LAT2 Utilized transport
reversible: false

metaR UMPK6n
modifier: MODEL1310110054#
is described by: ECO:0000269
is: SBO:0000176
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110054#
product: MODEL1310110054#
name: UMP kinase (dCTP),nuclear
reactant: MODEL1310110054#

metaR r0998
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110054#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
reversible: true
name: Facilitated diffusion
fast: false

metaM lac L e
name: (S)-lactate
is: CHEBI:16651
initial concentration: 1.0
initial amount: NaN
is: HMDB00190
is: SBO:0000247
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
constant: false
type: Species
has only substance units: false
boundary condition: false

metaR RE2666C
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110054#
name: RE2666
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:
type: Reaction
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110054#_29ecbb5d_e478_4a68_8bc2_be3a8287ecd9
boundary condition: true
is: Q96BD0
initial amount: NaN
initial concentration: NaN
type: Species
name: SLCO4A1
is encoded by: hsa:28231
constant: false
is: SBO:0000252
has only substance units: false

metaR DOLP Lter
fast: false
reversible: false
product: MODEL1310110054#
is described by: ECO:0000000
reactant: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#
name: dolichol phosphate flippase (liver)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
type: Reaction

metaR r2085
kinetic law: MODEL1310110054#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110054#
reversible: true
type: Reaction
modifier: MODEL1310110054#
fast: false

metaR r2201
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110054#
modifier: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_438641d7_fc9e_45da_8fc4_d9e9d76f0e0a
constant: false
has only substance units: false
is encoded by: hsa:518
type: Species
boundary condition: true
initial concentration: NaN
has part: P48201
initial amount: NaN
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2

metaM CE0713 m
constant: false
name: 3-oxolinoleoyl-CoA
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:30623
boundary condition: false
type: Species
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
initial amount: NaN
is: HMDB02329
has only substance units: false

metaR S23T4g
reactant: MODEL1310110054#
reversible: false
fast: false
name: beta-galactoside alpha-2,3-sialyltransferase
type: Reaction
product: MODEL1310110054#
modifier: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.99.4
is: SBO:0000176
kinetic law: MODEL1310110054#

metaR r2359
fast: false
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110054#
reversible: true
product: MODEL1310110054#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_fd34e058_12d9_42be_895d_698d45738030
is: SBO:0000252
has only substance units: false
boundary condition: true
name: PDE8A
constant: false
is encoded by: hsa:5151
initial amount: NaN
initial concentration: NaN
type: Species

metaM oxa e
boundary condition: false
constant: false
is: CHEBI:30623
type: Species
has only substance units: false
is: HMDB02329
initial concentration: 1.0
name: oxalate(2-)
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209

metaM ocdca c
is: HMDB00827
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: stearate
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
is: CHEBI:25629

http://identifiers.org/biomodels.db/MODEL1310110054#_f10dd63a_b904_4c65_ad84_82b325e98641
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
name: ENTPD1
boundary condition: true
is: SBO:0000252
constant: false
is: Q86VV3
is encoded by: hsa:953

http://identifiers.org/biomodels.db/MODEL1310110054#_f8ec1cbf_6b7b_4b8d_871b_9fd8bdaaa884
has only substance units: false
type: Species
has part: Q8WYR1
boundary condition: true
name: PIK3R5:PIK3CG
is encoded by: hsa:23533
is: SBO:0000297
constant: false
initial amount: NaN
initial concentration: NaN

metaR r0321
product: MODEL1310110054#
is described by: ECO:0000000
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
type: Reaction
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/6.3.5.2
fast: false
is: SBO:0000176
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
reversible: false

metaM acetone c
has only substance units: false
is: SBO:0000247
is: CHEBI:15347
boundary condition: false
is: HMDB01659
name: acetone
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaR PIK3
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.1.154
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.137
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.1.153
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
name: phosphatidylinositol 3-kinase

metaR RE0567C
reactant: MODEL1310110054#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
is described by: ECO:0000000
product: MODEL1310110054#
type: Reaction
name: RE0567
reversible: true

metaR r0999
name: Facilitated diffusion
fast: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
is described by: ECO:0000000

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaR r2086
kinetic law: MODEL1310110054#
product: MODEL1310110054#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
modifier: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#

metaR r0642
reactant: MODEL1310110054#
fast: false
product: MODEL1310110054#
reversible: true
is described by: ECO:0000000
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110054#_f5544af2_4666_43fd_8015_4fde2326713c
constant: false
name: CPOX
initial concentration: NaN
type: Species
is: SBO:0000252
is: P36551
boundary condition: true
initial amount: NaN
is encoded by: hsa:1371
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_a1230a58_7592_47f4_bec2_f6b94b5a0f85
is: SBO:0000252
name: PDE5A
type: Species
initial concentration: NaN
is: O76074
constant: false
initial amount: NaN
is encoded by: hsa:8654
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_7d2b47de_61ab_41a3_8a63_7b6c727ca360
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: TUSC3
boundary condition: true
is: Q13454
constant: false
is encoded by: hsa:7991
type: Species
is: SBO:0000252

metaM hexdicoa x
name: hexadecanedioylcoa
has only substance units: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB02288
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110054#_metaR_ACGALFUCGALACGALFUCGALACGLCGAL14ACGLCGALGLUSIDEtg
fast: false
reversible: true
reactant: MODEL1310110054#
is: SBO:0000185
product: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
name: blood group intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110054#_e7afddc2_3fb8_4da8_b14a_2d1bb7ca4554
initial concentration: NaN
name: ALG12
initial amount: NaN
boundary condition: true
is encoded by: hsa:79087
is: SBO:0000252
constant: false
is: Q9BV10
type: Species
has only substance units: false

metaM ribflv c
notes: FORMULA: C17H20N4O6 CHARGE: 0
type: Species
boundary condition: false
is: SBO:0000247
name: Riboflavin
constant: false
is: CHEBI:3554
initial concentration: 1.0
initial amount: NaN
is: C00255
is: HMDB00244
has only substance units: false

metaR ADSK
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
kinetic law: MODEL1310110054#
is described by: ECO:0000269
name: adenylyl-sulfate kinase
is version of: http://identifiers.org/ec-code/2.7.1.25
reversible: false
type: Reaction
reactant: MODEL1310110054#
is: SBO:0000176
modifier: MODEL1310110054#
fast: false

metaR RE0512M
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110054#
product: MODEL1310110054#
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE0512
is version of: http://identifiers.org/ec-code/4.2.1.107

http://identifiers.org/biomodels.db/MODEL1310110054#_a27fbe38_2d6e_4f23_9f81_8dde14ca519c
initial amount: NaN
is encoded by: hsa:27068
constant: false
is: F8WDN9
has only substance units: false
name: PPA2
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_b1d11a7c_bef7_4eb0_8c51_4cb8ce231ecb
has only substance units: false
is: SBO:0000252
is: Q8WWX8
is encoded by: hsa:115584
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
boundary condition: true
name: SLC5A11

metaR r2087
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_ab2ced51_9032_4d59_aede_4b3908dba321
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:AA629629
name: _AA629629_1_m
initial amount: NaN
initial concentration: NaN
type: Species

metaR CSBPASEly
type: Reaction
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
is described by: ECO:0000000
reactant: MODEL1310110054#
reversible: false
fast: false
product: MODEL1310110054#
is: SBO:0000176
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)

metaM ocdca e
initial amount: NaN
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
constant: false
boundary condition: false
is: SBO:0000247
name: octadecanoate (n-C18:0)
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00827
is: CHEBI:25629
is: C01530

metaR P45027A14m
product: MODEL1310110054#
is: SBO:0000176
kinetic law: MODEL1310110054#
name: 5-beta-cytochrome P450, family 27, subfamily A, polypeptide 1
reactant: MODEL1310110054#
fast: false
reversible: false
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000269
type: Reaction

metaM ksii core2 deg7 l
is: SBO:0000247
boundary condition: false
is: CHEBI:16953
initial amount: NaN
has only substance units: false
is: HMDB00812
notes: FORMULA: C44H73N4O30X CHARGE: 0
constant: false
initial concentration: 1.0
type: Species
name: keratan sulfate II (core 2-linked), degradation product 7

http://identifiers.org/biomodels.db/MODEL1310110054#_153f13f3_ab84_4fae_b494_6dba8ad58220
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2799
is: SBO:0000252
type: Species
boundary condition: true
constant: false
name: GNS
is: Q7Z3X3
initial amount: NaN

metaM ksii core4 pre3 g
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 3
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:58053
constant: false
is: C00130
initial concentration: 1.0
boundary condition: false
is: HMDB00175
notes: FORMULA: C55H89N5O38X CHARGE: -1

metaM hs deg13 l
has only substance units: false
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
boundary condition: false
is: CHEBI:17180
initial amount: NaN
is: HMDB01352
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
name: heparan sulfate, degradation product 13

metaM ksi pre3 g
is: SBO:0000247
initial concentration: 1.0
type: Species
is: C00130
initial amount: NaN
boundary condition: false
notes: FORMULA: C93H152N6O67X CHARGE: -1
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 3
is: CHEBI:58053
has only substance units: false
constant: false

metaR GTHRDt
kinetic law: MODEL1310110054#
is: SBO:0000185
fast: false
name: Glutathione transport into mitochondria
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
is described by: ECO:0000000
product: MODEL1310110054#
type: Reaction
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_54473f46_af1e_4619_8ca4_9e00e70333c4
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
boundary condition: true
is encoded by: hsa:522
has part: Q6NZ59
type: Species
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000297

metaM ppa e
constant: false
type: Species
has only substance units: false
is: HMDB00237
is: CHEBI:17272
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial amount: NaN
boundary condition: false
name: propionate

metaM 5tedtricoa m
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
name: 5,8,11-tetradecatrienoylcoa
has only substance units: false
is: HMDB02288

metaR r2080
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110054#

metaR FTHFL
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.5
modifier: MODEL1310110054#
is described by: ECO:0000134
fast: false
type: Reaction
name: Formate-tetrahydrofolate ligase
product: MODEL1310110054#
kinetic law: MODEL1310110054#
is: SBO:0000176
reactant: MODEL1310110054#

metaR ADSS
is described by: ECO:0000134
reactant: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/6.3.4.4
fast: false
kinetic law: MODEL1310110054#
is: SBO:0000176
type: Reaction
name: adenylosuccinate synthase
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
modifier: MODEL1310110054#
reversible: false

metaM tag hs e
is: CHEBI:17855
name: triglyceride
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR ALASERNaEx
fast: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110054#
reversible: false
modifier: MODEL1310110054#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
name: L-alanine/L-serine Na-dependent exchange (Ala-L in)
reactant: MODEL1310110054#

metaM fum c
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
is: HMDB00134
name: Fumarate
is: C00122
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:29806
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_94a83866_2a82_4c8b_8e45_5655b430b43e
initial amount: NaN
type: Species
is: O76062
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:7108
constant: false
name: TM7SF2

http://identifiers.org/biomodels.db/MODEL1310110054#_469242b0_22a3_48bf_82ff_b16e1e0d62d9
name: NDUFA2
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
is: O43678
has only substance units: false
is encoded by: hsa:4695

metaM r5p c
is: CHEBI:18189
is: C00117
constant: false
name: alpha-D-Ribose 5-phosphate
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
has only substance units: false
is: HMDB00618
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247

metaR MTHFCm
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.3
modifier: MODEL1310110054#
kinetic law: MODEL1310110054#
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/3.5.4.9
is: SBO:0000176
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
type: Reaction
product: MODEL1310110054#

metaM dag hs e
boundary condition: false
type: Species
constant: false
is: SBO:0000247
name: diglyceride
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:18035
initial concentration: 1.0

metaR r0641
kinetic law: MODEL1310110054#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.4
fast: false
product: MODEL1310110054#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
reactant: MODEL1310110054#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110054#
reversible: true
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2

http://identifiers.org/biomodels.db/MODEL1310110054#_98bc898b_29a0_427a_be65_233fc705053f
constant: false
has only substance units: false
is encoded by: hsa:4882
name: NPR2
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR r2081
fast: false
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is: SBO:0000185
product: MODEL1310110054#
reactant: MODEL1310110054#

metaM gchola c
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00138
name: glycocholate
initial amount: NaN
constant: false
is: CHEBI:58235
type: Species
is: SBO:0000247
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921

metaR LCADi
kinetic law: MODEL1310110054#
name: lactaldehyde dehydrogenase
reactant: MODEL1310110054#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.36
type: Reaction
reversible: false
is described by: ECO:0000304
product: MODEL1310110054#
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR S6T2g
type: Reaction
product: MODEL1310110054#
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110054#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110054#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_cc9bf254_16f5_4e1e_8185_c078589e90bd
is encoded by: hsa:38
boundary condition: true
is: P24752
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
name: ACAT1

metaM HC01231 c
constant: false
initial concentration: 1.0
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
is: CHEBI:58480
has only substance units: false
name: N-[(R)-pantothenoyl]-L-cysteinate
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247

metaM ppa c
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: HMDB00237
is: CHEBI:17272
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
name: propionate
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR Rtotaltl
name: fatty acid intracellular transport
product: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - carnitine transporters not found, unknown mechanism intracellularly, however there must be a mechanism for FA transport NJ
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
reversible: true

metaR MALSO3tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
reversible: true
name: Malate:sulfite antiport, mitochondrial
product: MODEL1310110054#
reactant: MODEL1310110054#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#
type: Reaction

metaR GLCtly
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
kinetic law: MODEL1310110054#
is described by: ECO:0000000
fast: false
name: glucose efflux from lysosome
is: SBO:0000185
reversible: false
reactant: MODEL1310110054#
type: Reaction

metaM bamppald c
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
name: beta-Aminopropion aldehyde
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
type: Species
initial amount: NaN
is: C05665
is: HMDB01106
is: http://identifiers.org/pubchem.compound/7975
has only substance units: false

metaM lnlnca r
is: HMDB01388
constant: false
has only substance units: false
name: alpha-linolenate
is: CHEBI:32387
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR r2082
reversible: true
modifier: MODEL1310110054#
is: SBO:0000185
reactant: MODEL1310110054#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110054#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110054#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110054#_bc780da6_78bd_4d7c_b9cb_fb10b072c081
is encoded by: hsa:7360
type: Species
constant: false
is: SBO:0000252
name: UGP2
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM leuktrE4 e
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: HMDB02200
is: SBO:0000247
name: leukotriene E4(1-)
is: CHEBI:57462
initial concentration: 1.0

metaM hmbil c
notes: FORMULA: C40H38N4O17 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00628 EHMN_ABBREVIATION: C01024
is: C01024
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB01137
name: Hydroxymethylbilane
is: CHEBI:57845
has only substance units: false
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_6a16f474_547c_4fff_8adc_934a819d6a36
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9UN42
constant: false
is encoded by: hsa:23439
boundary condition: true
initial concentration: NaN
name: ATP1B4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_4e068ef0_8067_44f8_b4c8_3fff1284e4dd
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: NDUFS5
type: Species
initial amount: NaN
is: Q6IBA0
is encoded by: hsa:4725
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_601b15e1_f670_40f6_b683_769588b8c44a
name: GALT
is: SBO:0000252
constant: false
is encoded by: hsa:2592
type: Species
has only substance units: false
initial concentration: NaN
is: B2RAT6
initial amount: NaN
boundary condition: true

metaM gchola e
initial concentration: 1.0
name: glycocholate
is: SBO:0000247
is: HMDB00138
type: Species
initial amount: NaN
notes: FORMULA: C26H43NO6 CHARGE: 0
constant: false
boundary condition: false
has only substance units: false

metaR DTDPtn
is: SBO:0000185
product: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
reversible: true
is described by: ECO:0000000
name: dTDP nuclear transport
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
type: Reaction

metaR r2083
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110054#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110054#
product: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_63c515f9_ac1c_40b7_90b4_58c8aa1772d3
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:5244
is: SBO:0000252
initial amount: NaN
type: Species
name: ABCB4
boundary condition: true
is: A4D1D5

metaM dag hs r
boundary condition: false
type: Species
constant: false
is: CHEBI:18035
name: diglyceride
has only substance units: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_a816e215_127f_4e84_881f_73a627efc4c0
type: Species
boundary condition: true
is: H0YMZ7
is encoded by: hsa:5151
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: PDE8A
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_f933caeb_72e4_4d45_bdce_9dd1460c0630
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:93034
name: NT5C1B
is: B3KUK6
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaM m1mpdol L c
has only substance units: false
boundary condition: false
notes: FORMULA: C1360H2228N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
constant: false
is: CHEBI:28067
is: SBO:0000247
type: Species
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
initial concentration: 1.0

metaR UDPG4E
name: UDPglucose 4-epimerase
kinetic law: MODEL1310110054#
is version of: http://identifiers.org/ec-code/5.1.3.2
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
reactant: MODEL1310110054#
type: Reaction
reversible: true
is described by: ECO:0000134
product: MODEL1310110054#
fast: false
is: SBO:0000176
modifier: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_724618b3_8bfe_4cf3_8793_51b458b9d5e8
name: DDC
is: Q53Y41
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1644
type: Species
constant: false

metaR r2353
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
product: MODEL1310110054#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
name: Organic anion transporter 5 Utilized transport

metaR r0797
product: MODEL1310110054#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110054#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
name: glycine N-choloyltransferase EC:2.3.1.65
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
reversible: true
is: SBO:0000176
reactant: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_7b8db473_9717_41f1_af5c_817d4e9cba24
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: B4DK61
is encoded by: hsa:51
constant: false
boundary condition: true
initial concentration: NaN
name: ACOX1

metaM man1p c
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: HMDB06330
name: D-Mannose 1-phosphate
is: CHEBI:35374

metaM lnlncg r
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:32391
is: HMDB03073
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
name: gamma-linolenate

http://identifiers.org/biomodels.db/MODEL1310110054#_5a668061_5412_46bf_8cca_475913390e74
name: DGKI
is encoded by: hsa:9162
type: Species
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: O75912
is: SBO:0000252

metaM o2 c
has only substance units: false
is: HMDB01377
type: Species
constant: false
is: CHEBI:15379
boundary condition: false
initial concentration: 1.0
is: C00007
initial amount: NaN
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: SBO:0000247
name: O2

metaM malcoa c
is: C00083
name: Malonyl-CoA
type: Species
is: CHEBI:57384
is: HMDB01175
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110054#_270fa6a1_8c68_4e23_8e6d_b0ef795e90d0
type: Species
has only substance units: false
constant: false
name: _7359_1_c
boundary condition: true
initial amount: NaN
is encoded by: hsa:7359
is: SBO:0000252
initial concentration: NaN

metaM hexdicoa r
is: SBO:0000247
initial amount: NaN
is: HMDB00672
initial concentration: 1.0
is: C08260
has only substance units: false
constant: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
boundary condition: false
type: Species
name: hexadecanedioylcoa

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_7261a52d_9284_4e14_9709_f4ec64b2434d
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR r2354
reactant: MODEL1310110054#
type: Reaction
kinetic law: MODEL1310110054#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110054#
fast: false
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000

metaR ASCBt
name: L-ascorbate transport via facilitated diffusion
reversible: true
reactant: MODEL1310110054#
fast: false
is described by: ECO:0000000
product: MODEL1310110054#
is: SBO:0000185
kinetic law: MODEL1310110054#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD

metaR INSTt4 2
is: SBO:0000185
name: inositol transport via sodium symport
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
reactant: MODEL1310110054#
is described by: ECO:0000006
reversible: true
product: MODEL1310110054#
fast: false
type: Reaction
kinetic law: MODEL1310110054#
modifier: MODEL1310110054#

http://identifiers.org/biomodels.db/MODEL1310110054#_b755816a_ea90_4b3e_8f6a_d33094404f17
is: O00483
name: NDUFA4
has only substance units: false
is encoded by: hsa:4697
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_71de1432_eac8_4e89_ac3f_5e00c884226b
is encoded by: hsa:11182
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
name: SLC2A6
is: Q9UGQ3

http://identifiers.org/biomodels.db/MODEL1310110054#_d705815b_773a_479d_a888_44c7916555d8
is encoded by: hsa:218
initial amount: NaN
has only substance units: false
type: Species
is: P30838
is: SBO:0000252
constant: false
initial concentration: NaN
name: ALDH3A1
boundary condition: true

metaR FAOXC184x
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_5e4130f3_6c97_442e_8315_52182dcb8381
has only substance units: false
name: ITPKC
is: Q96DU7
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:80271
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110054#_3eff27cd_b549_4ff2_baf3_2af58e826abd
has only substance units: false
constant: false
is: A8K0I1
is: SBO:0000252
boundary condition: true
name: DGKH
initial amount: NaN
is encoded by: hsa:160851
initial concentration: NaN
type: Species

metaR r0795
is: SBO:0000176
reactant: MODEL1310110054#
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.1.1.225
kinetic law: MODEL1310110054#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Unassigned EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
name: Spontaneous reaction
product: MODEL1310110054#

metaR CERT1rt
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
is version of: http://identifiers.org/ec-code/2.7.11.1
name: ceramide transport protein
modifier: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
kinetic law: MODEL1310110054#
fast: false
is described by: ECO:0000304
type: Reaction
reversible: true
is: SBO:0000185

metaM cdp c
initial amount: NaN
is: C00112
is: HMDB01546
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:58069
name: CDP
constant: false
has only substance units: false
type: Species
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112

metaM oxa m
constant: false
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial concentration: 1.0
boundary condition: false
is: HMDB02329
initial amount: NaN
is: CHEBI:30623
name: oxalate(2-)

metaR G5SDym
type: Reaction
name: glutamate-5-semialdehyde dehydrogenase (m)
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.41
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 1.2.1.41 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m TDV: name change from G5SDm
modifier: MODEL1310110054#
is: SBO:0000176
is described by: ECO:0000254
reactant: MODEL1310110054#
product: MODEL1310110054#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110054#_6415a006_22fe_4daa_afb5_0e7b3353f087
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1717
name: DHCR7
is: Q9UBM7

http://identifiers.org/biomodels.db/MODEL1310110054#_7e83f5d7_e9c9_4dae_8f26_7d195f7154af
name: PRDX2
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:7001
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110054#_76d82dad_75be_4158_836a_ec1e2ad459bb
is encoded by: hsa:8833
type: Species
is: P49915
is: SBO:0000252
name: GMPS
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false

metaM icit x
is: HMDB00193
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
has only substance units: false
boundary condition: false
is: CHEBI:16087
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
name: isocitrate(3-)

http://identifiers.org/biomodels.db/MODEL1310110054#_13ebfebe_244f_4bd4_ba5b_0fbf9ffe28a4
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:5959
is: Q92781
name: RDH5
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_628103b7_9ada_484b_98da_d22489894373
type: Species
is encoded by: hsa:8854
initial amount: NaN
constant: false
boundary condition: true
is: F5H2Y9
name: ALDH1A2
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110054#_aaa11fd4_36d3_4e39_b4ca_eaf7107c6878
initial concentration: NaN
is encoded by: hsa:5283
constant: false
initial amount: NaN
name: PIGH
type: Species
is: SBO:0000252
is: Q14442
boundary condition: true
has only substance units: false

metaR r2352
kinetic law: MODEL1310110054#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
is: SBO:0000185
fast: false
name: Organic anion transporter 5 Utilized transport

metaM hs deg10 l
is: HMDB00127
constant: false
name: heparan sulfate, degradation product 10
initial amount: NaN
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:15748

metaR SUCCOAPET
kinetic law: MODEL1310110054#
product: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaR r0796
reversible: true
is: SBO:0000176
fast: false
kinetic law: MODEL1310110054#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56

metaR EX fuc L LPAREN e RPAREN
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Fucose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110054#_676f1727_c013_405f_a520_d3266c5c375b
has only substance units: false
initial amount: NaN
is: Q9H310
name: RHBG
boundary condition: true
type: Species
is encoded by: hsa:57127
constant: false
initial concentration: NaN
is: SBO:0000252

metaR DHCR241r
modifier: MODEL1310110054#
product: MODEL1310110054#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.72
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
kinetic law: MODEL1310110054#
reversible: false
name: 24-dehydrocholesterol reductase [Precursor]
reactant: MODEL1310110054#
is described by: ECO:0000134
fast: false

metaR G14T19g
fast: false
modifier: MODEL1310110054#
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110054#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is described by: ECO:0000000
reversible: false
product: MODEL1310110054#

metaR r0570
modifier: MODEL1310110054#
type: Reaction
product: MODEL1310110054#
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
is: SBO:0000176
fast: false
kinetic law: MODEL1310110054#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.3.2
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110054#_3ed0f71d_4437_4d7d_9e6a_fc375b4c29bc
initial concentration: NaN
name: NDUFS3
is: SBO:0000252
is: O75489
has only substance units: false
type: Species
is encoded by: hsa:4722
initial amount: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110054#_a4d514ed_246c_4264_8e71_bc6f36bfa2a1
has only substance units: false
initial amount: NaN
constant: false
is: P11169
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: SLC2A3
is encoded by: hsa:6515
type: Species

metaM o2 e
name: O2
is: HMDB01377
is: SBO:0000247
constant: false
type: Species
is: CHEBI:15379
has only substance units: false
initial amount: NaN
is: C00007
boundary condition: false
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007

metaR TYROXDAc
type: Reaction
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/1.4.3.4
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
fast: false
modifier: MODEL1310110054#

metaR r2088
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110054#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110054#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110054#
type: Reaction
fast: false
product: MODEL1310110054#

metaR r0575
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110054#
product: MODEL1310110054#
is version of: http://identifiers.org/ec-code/2.7.1.48
reactant: MODEL1310110054#
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
type: Reaction
modifier: MODEL1310110054#
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
is: SBO:0000176

metaM dag hs n
type: Species
is: CHEBI:18035
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
name: diglyceride
constant: false

metaR DM anth
kinetic law: MODEL1310110054#
reactant: MODEL1310110054#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaM itp e
name: ITP(3-)
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:57614
is: SBO:0000247
is: HMDB00189
has only substance units: false
boundary condition: false
type: Species