metaM his L e
is: SBO:0000247
has only substance units: false
is: CHEBI:15971
initial amount: NaN
is: HMDB00177
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
type: Species
initial concentration: 1.0
name: L-histidine
boundary condition: false
constant: false

metaR SIAT4Bg
reversible: false
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.99.4
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
kinetic law: MODEL1310110053#
fast: false
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
type: Reaction
reactant: MODEL1310110053#

metaM udpgal c
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: HMDB00302
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58439
name: UDP-D-galactose(2-)
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_ab9d86a6_f7a8_4123_8076_98d91aa9e119
name: DPAGT1
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:1798
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR FAOXC140
is: SBO:0000176
type: Reaction
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110053#
is described by: ECO:0000269
product: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_bf66bcd8_adfc_4586_a246_35047f14539d
has only substance units: false
constant: false
is encoded by: hsa:BE966236
initial concentration: NaN
type: Species
initial amount: NaN
name: _BE966236_1_m
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_703821bc_35d4_4de0_929a_0b93ba16c15c
boundary condition: true
is: Q16706
initial amount: NaN
name: MAN2A1
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:4124
is: SBO:0000252

metaM h2o x
is: CHEBI:15377
initial concentration: 1.0
is: HMDB02111
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: C00001
name: H2O
constant: false

metaM lnlncg e
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: HMDB03073
name: gamma-linolenate
boundary condition: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:32391

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR ARACHDtr
fast: false
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
is: SBO:0000185
product: MODEL1310110053#
reversible: true
name: intracellular transport
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110053#

metaR r0842
is version of: http://identifiers.org/ec-code/1.3.1.72
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110053#
name: Postulated transport reaction
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
product: MODEL1310110053#

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaM duri e
name: Deoxyuridine
is: C00526
is: HMDB00012
constant: false
is: CHEBI:16450
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526

metaM acngalgbside hs g
boundary condition: false
is: HMDB03406
is: SBO:0000247
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
has only substance units: false
name: sialyl galactosylgloboside
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16523
constant: false
type: Species

metaM asn L e
is: CHEBI:17196
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: HMDB00168
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: L-asparagine
constant: false
initial amount: NaN

metaM retinal 11 cis c
initial amount: NaN
type: Species
is: HMDB02152
boundary condition: false
is: CHEBI:16066
is: SBO:0000247
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
constant: false
name: 11-cis-retinal
has only substance units: false
initial concentration: 1.0

metaR TDCHOLAte
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
fast: false
product: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110053#
type: Reaction

metaR HISCAT1
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaR C204CRNt
name: arachidonic acid transport into the mitochondria
kinetic law: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
reversible: false
reactant: MODEL1310110053#
fast: false

metaM xol7ah2al c
type: Species
is: SBO:0000247
initial amount: NaN
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
has only substance units: false
is: HMDB06894
constant: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: CHEBI:27428
boundary condition: false
initial concentration: 1.0

metaM ha l
name: hyaluronan
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:16336
has only substance units: false

metaR URAt
modifier: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000269
reversible: true
name: uracil transport via facilated diffusion
fast: false
type: Reaction
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT

metaR r2506
product: MODEL1310110053#
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
kinetic law: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
name: Utilized transport
is described by: ECO:0000000

metaM HC02187 e
is: SBO:0000247
name: reverse-triiodthyronine
initial amount: NaN
boundary condition: false
constant: false
type: Species
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
is: CHEBI:28774
initial concentration: 1.0
has only substance units: false

metaR DHORD9
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
modifier: MODEL1310110053#
type: Reaction
name: dihydoorotic acid dehydrogenase (quinone10)
fast: false
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.3.5.2
reactant: MODEL1310110053#
product: MODEL1310110053#

metaM 3aib D m
is: HMDB02299
type: Species
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: C03265
name: D-3-Amino-isobutanoate
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: SBO:0000247

metaM ha pre1 l
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
name: hyaluronan biosynthesis, precursor 1
type: Species
constant: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
is: CHEBI:16126

http://identifiers.org/biomodels.db/MODEL1310110053#_1af786ba_44ab_4c82_91e4_593bc38336fe
type: Species
initial concentration: NaN
is encoded by: hsa:6487
is: SBO:0000252
initial amount: NaN
is: Q11203
constant: false
name: ST3GAL3
has only substance units: false
boundary condition: true

metaM thr L c
type: Species
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
boundary condition: false
is: HMDB00167
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16857
is: SBO:0000247
name: L-threonine
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_28e4ee39_cba1_42c9_84e8_6afa7c4e34cc
initial concentration: NaN
is: Q9UIG8
boundary condition: true
initial amount: NaN
name: SLCO3A1
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:28232
has only substance units: false

metaR r2372
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110053#
is: SBO:0000185
reactant: MODEL1310110053#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_d93636d1_bf84_4a2a_b898_e9884c5b1cb5
constant: false
name: B3GNT1
is encoded by: hsa:11041
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: O43505
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_2e182216_a271_4c2f_b841_2c89e0c2d1cf
is: SBO:0000252
is: E9KL42
boundary condition: true
initial amount: NaN
name: ACOT1
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:641371

metaR ARACHCRNt
name: transport into the mitochondria (carnitine)
reversible: false
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
product: MODEL1310110053#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_5f3d3648_f4ab_4235_9be7_9c2a26fcfe38
is encoded by: hsa:5244
boundary condition: true
constant: false
name: ABCB4
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species

metaR Htx
is: SBO:0000185
name: H transporter, peroxisome
is described by: ECO:0000000
fast: false
reactant: MODEL1310110053#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110053#
product: MODEL1310110053#

metaM udpg r
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:58367
has only substance units: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: SBO:0000247
is: HMDB00286
constant: false

metaR PCm
reversible: false
product: MODEL1310110053#
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000176
modifier: MODEL1310110053#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.4.1.1
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
name: pyruvate carboxylase

http://identifiers.org/biomodels.db/MODEL1310110053#_cb4ba55b_7e49_4d8d_bfe1_1d9e63eb0075
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
name: FOLR1
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2348

metaM 34dhoxmand c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27637
name: 3,4-Dihydroxymandelate
is: HMDB01866
has only substance units: false
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
boundary condition: false
type: Species
constant: false
is: SBO:0000247

metaR CYTK10n
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
name: cytidylate kinase (CMP,dGTP),nuclear
reversible: true
modifier: MODEL1310110053#
is described by: ECO:0000269
product: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110053#
fast: false

metaM lnlncg c
is: CHEBI:32391
has only substance units: false
type: Species
name: gamma-linolenate
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB03073

http://identifiers.org/biomodels.db/MODEL1310110053#_65d87ad1_cc51_45ed_9a08_f0787b26115a
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
name: _AA532636_1_m
is encoded by: hsa:AA532636
constant: false
boundary condition: true

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_791e3fa5_ecf0_475a_b370_0456571609a7
constant: false
initial concentration: NaN
name: EARS2
type: Species
is encoded by: hsa:124454
initial amount: NaN
boundary condition: true
is: Q5JPH6
has only substance units: false
is: SBO:0000252

metaM acald m
constant: false
is: HMDB00990
is: CHEBI:15343
name: acetaldehyde
has only substance units: false
initial amount: NaN
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_036f366b_9aaf_4d58_9830_21289c970374
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
name: ST3GAL3
is encoded by: hsa:6487
type: Species
is: SBO:0000252

metaM asn L c
has only substance units: false
initial amount: NaN
is: CHEBI:17196
is: HMDB00168
type: Species
boundary condition: false
name: L-asparagine
initial concentration: 1.0
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: SBO:0000247
constant: false

metaM gdpfuc g
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
name: GDP-L-fucose(2-)
is: CHEBI:57984
has only substance units: false
is: HMDB01095
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_7d884831_a764_478c_a34e_6ed1aad5e13e
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3945
initial concentration: NaN
has only substance units: false
type: Species
name: LDHB
is: P07195
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_5ce6c47d_6378_4571_b865_c884c09b8c33
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:AL525798
is: SBO:0000252
name: _AL525798_1_c
initial concentration: NaN
type: Species

metaR r2371
fast: false
product: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110053#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110053#
reversible: true
is described by: ECO:0000000

metaM 5mta e
is: CHEBI:17509
has only substance units: false
is: C00170
notes: FORMULA: C11H15N5O3S CHARGE: 0
is: HMDB01173
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
name: 5-Methylthioadenosine

http://identifiers.org/biomodels.db/MODEL1310110053#_109cea64_454d_4931_a45f_d1acf9bce10e
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is: Q8NFL0
initial amount: NaN
has only substance units: false
name: B3GNT7
is encoded by: hsa:93010

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaM mn l
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
constant: false
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
name: beta-1,4-mannose-N-acetylglucosamine
is: HMDB06535

http://identifiers.org/biomodels.db/MODEL1310110053#_6f8d3ce2_eacf_4da8_9281_0910d3e0c0db
initial amount: NaN
has only substance units: false
is encoded by: hsa:126328
is: SBO:0000252
type: Species
boundary condition: true
is: C9JT23
constant: false
initial concentration: NaN
name: NDUFA11

metaR GGH 5DHFe
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
reversible: false
reactant: MODEL1310110053#
name: Gamma-glutamyl hydrolase (5DHF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
is described by: ECO:0000000
modifier: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#

metaM nadph r
constant: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:57783
is: HMDB00221
type: Species
name: Nicotinamide adenine dinucleotide phosphate - reduced
has only substance units: false
initial amount: NaN
is: C00005

metaM tststerone r
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: SBO:0000247
is: CHEBI:17347
name: testosterone
is: HMDB00234
boundary condition: false
has only substance units: false
type: Species

metaR BILGLCURtr
product: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
name: glucuronidated compound transport
reversible: true
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_41447c93_9d6c_460d_8f63_28cd8cfda17d
initial amount: NaN
has only substance units: false
is encoded by: hsa:6566
name: SLC16A1
constant: false
is: SBO:0000252
boundary condition: true
type: Species
is: B4DKS0
initial concentration: NaN

metaR r1951
is described by: ECO:0000000
product: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110053#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110053#
type: Reaction
reversible: false
reactant: MODEL1310110053#

metaM HC02204 c
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
boundary condition: false
name: prostaglandin-b1
initial concentration: 1.0
is: CHEBI:27624
initial amount: NaN
type: Species

metaM malthx e
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
type: Species
name: Maltohexaose
is: C01936
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_38715ace_0d11_44cb_b7bc_5c1b6d72a851
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110053#_a3b4918d_cd41_4dc5_bc58_a0bfadaae8db
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:85365
type: Species
is: Q9H553
name: ALG2
constant: false

metaM ppcoa c
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB01275
initial concentration: 1.0
type: Species
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial amount: NaN
is: C00100
is: CHEBI:57392
name: Propanoyl-CoA
has only substance units: false

metaM HC00718 c
name: N-methylethanolaminium phosphate(1-)
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:57781
initial amount: NaN

metaM lys L e
name: L-lysinium(1+)
is: HMDB00182
is: CHEBI:32551
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0

metaR r2374
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000185
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
type: Reaction

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_d0866d04_e961_42dd_8813_73a5d939ec7c
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:33
name: ACADL
is: P28330
has only substance units: false
type: Species
constant: false
initial amount: NaN

metaM Rtotal2coa c
initial amount: NaN
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
constant: false
type: Species
is: HMDB00095
name: R total 2 coenzyme A
is: CHEBI:60377
is: C00055
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM 34dhpha c
constant: false
name: (3,4-dihydroxyphenyl)acetate
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
is: CHEBI:17612
is: HMDB01336
is: SBO:0000247

metaR r0245
fast: false
is: SBO:0000176
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110053#
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.5.1.3
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72

http://identifiers.org/biomodels.db/MODEL1310110053#_0ee4a500_31d5_490d_82a2_9cf6e0ec833b
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaR GLUDym
fast: false
type: Reaction
modifier: MODEL1310110053#
product: MODEL1310110053#
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.1.3
reactant: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
name: glutamate dehydrogenase (NADP), mitochondrial
kinetic law: MODEL1310110053#

metaM gly x
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
initial concentration: 1.0
is: HMDB00123
is: SBO:0000247
initial amount: NaN
name: glycine
constant: false
is: CHEBI:15428
type: Species
has only substance units: false
boundary condition: false

metaR r2509
reversible: true
kinetic law: MODEL1310110053#
product: MODEL1310110053#
name: Utilized transport
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

metaM so4 e
boundary condition: false
is: CHEBI:16189
initial amount: NaN
initial concentration: 1.0
is: HMDB01448
has only substance units: false
constant: false
name: sulfate
is: SBO:0000247
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_ab7414a5_075f_4d07_a963_9cd0ccef6cdc
is encoded by: hsa:27068
name: PPA2
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species

metaR r2373
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110053#
reversible: true
product: MODEL1310110053#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_c2d4f0c8_3e9b_47c7_985f_20a2c2d029c0
initial concentration: NaN
constant: false
is encoded by: hsa:38
type: Species
boundary condition: true
is: P24752
has only substance units: false
is: SBO:0000252
name: ACAT1
initial amount: NaN

metaM ksi pre14 g
has only substance units: false
is: CHEBI:28067
boundary condition: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 14
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
type: Species

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaM 5mta c
boundary condition: false
is: HMDB01173
is: CHEBI:17509
is: C00170
is: SBO:0000247
has only substance units: false
name: 5-Methylthioadenosine
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_47b95512_dc52_44bf_851b_485ab1282993
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: B3GNT8
constant: false
is encoded by: hsa:374907
type: Species
has only substance units: false

metaR PROSTGI2tr
product: MODEL1310110053#
is described by: ECO:0000269
kinetic law: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
fast: false
reactant: MODEL1310110053#
reversible: true
is: SBO:0000185
name: Prostaglandin I2 transport (ER)

metaR O2tm
fast: false
name: O2 transport (diffusion)
reversible: true
type: Reaction
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
kinetic law: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110053#_121d437a_aeda_4ae7_9f93_32c6cac0c680
type: Species
is encoded by: hsa:91373
constant: false
is: Q3KQV9
boundary condition: true
has only substance units: false
initial amount: NaN
name: UAP1L1
is: SBO:0000252
initial concentration: NaN

metaR DESAT18 3
kinetic law: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
fast: false
product: MODEL1310110053#
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.14.19.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reversible: false
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110053#_3742f2ad_426f_404a_b378_ad283bdb97a1
is: B4DH54
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:2710
name: GK
boundary condition: true

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_4f70192d_0bde_4bbe_824f_479e12eddf27
is encoded by: hsa:64077
is: SBO:0000252
is: Q9H008
constant: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
name: LHPP
has only substance units: false

metaM xylu L c
name: L-xylulose
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:17399
has only substance units: false
initial amount: NaN
type: Species
is: HMDB00751
is: SBO:0000247

metaM fn2m2masn g
type: Species
constant: false
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
initial amount: NaN
has only substance units: false
is: CHEBI:32984

http://identifiers.org/biomodels.db/MODEL1310110053#_9d0ed738_d515_4237_b6ab_e7074368d96d
is encoded by: hsa:4669
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
is: P54802
constant: false
name: NAGLU
initial amount: NaN
has only substance units: false

metaR r2376
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110053#
reversible: true

metaM his L c
name: L-histidine
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
constant: false
is: SBO:0000247
is: CHEBI:15971
is: HMDB00177
boundary condition: false

metaM duri c
name: Deoxyuridine
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial concentration: 1.0
is: CHEBI:16450
type: Species
is: HMDB00012
is: C00526
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_47792580_b2ac_4dee_ac24_47a283c0d127
boundary condition: true
name: GALNT2
initial concentration: NaN
is: Q10471
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:2590
constant: false
initial amount: NaN

metaM L2aadp6sa c
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:17917
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB01263
name: L-allysine
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076

http://identifiers.org/biomodels.db/MODEL1310110053#_a8c33279_e345_46cc_9fd6_4c83992a98a9
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: Q9H0N5
name: PCBD2
type: Species
is encoded by: hsa:84105
has only substance units: false

metaR FADH2ETC
product: MODEL1310110053#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
name: Complex II reaction for respiratory chain

metaM h2o r
is: HMDB02111
is: SBO:0000247
constant: false
type: Species
is: C00001
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
has only substance units: false
name: H2O
initial concentration: 1.0
is: CHEBI:15377
initial amount: NaN

metaR r2507
reversible: true
product: MODEL1310110053#
name: Utilized transport
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#

metaM ha pre1 e
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:16126
name: hyaluronan biosynthesis, precursor 1
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
boundary condition: false
initial concentration: 1.0
constant: false
type: Species

metaM nadph m
has only substance units: false
boundary condition: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:57783
type: Species
initial amount: NaN
is: HMDB00221

metaR RE0830C
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
kinetic law: MODEL1310110053#
product: MODEL1310110053#
name: RE0830
reactant: MODEL1310110053#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
type: Reaction

metaM HC02187 c
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
name: reverse-triiodthyronine
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:28774

metaM pail4p hs n
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58178
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277

metaM ksi pre27 g
is: CHEBI:58053
is: C00130
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
type: Species
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00175
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 27

http://identifiers.org/biomodels.db/MODEL1310110053#_55b34094_614d_4a9a_a0ee_f575b4215582
type: Species
boundary condition: true
is encoded by: hsa:3030
constant: false
initial concentration: NaN
name: HADHA
is: E9KL44
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaR r2375
type: Reaction
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
product: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110053#

metaM ksi pre10 g
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
boundary condition: false
is: SBO:0000247
is: C00130
has only substance units: false
is: CHEBI:58053
type: Species
constant: false
name: keratan sulfate I biosynthesis, precursor 10
initial amount: NaN
is: HMDB00175
initial concentration: 1.0

metaR r0246
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
fast: false
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2

metaM guln c
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB03290
is: CHEBI:13115
is: SBO:0000247
boundary condition: false
name: L-gulonate
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
constant: false

metaR r2508
product: MODEL1310110053#
name: Utilized transport
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_5a9a2e22_4737_49de_aa5a_20fc7be99924
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:10558
has part: O15270
type: Species
is encoded by: hsa:9517
initial amount: NaN
constant: false
has part: O15269
is: SBO:0000297
name: SPTLC1:SPTLC2

http://identifiers.org/biomodels.db/MODEL1310110053#_3a9a4bac_3ace_42d8_91b9_fc7a120bd4c7
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:125206
is: A0PJK1
type: Species
constant: false
name: SLC5A10
is: SBO:0000252
initial concentration: NaN

metaR ACALDtm
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
is: SBO:0000185
type: Reaction
reactant: MODEL1310110053#
name: acetaldehyde mitochondrial diffusion

metaR ASNt4
is described by: ECO:0000269
name: L-asparagine transport in via sodium symport
reactant: MODEL1310110053#
is: SBO:0000185
fast: false
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: false
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB
product: MODEL1310110053#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_9277ca37_2af3_46f6_9edd_8e20e048d11a
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
name: BDH1
is encoded by: hsa:622

http://identifiers.org/biomodels.db/MODEL1310110053#_e40058af_42c8_47f1_9f07_1a8d96172e89
type: Species
name: SLC43A1
has only substance units: false
is encoded by: hsa:8501
initial concentration: NaN
boundary condition: true
is: O75387
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_d181e834_0728_4126_a928_7249021faf2f
name: PAFAH1B3
is encoded by: hsa:5050
has only substance units: false
constant: false
is: Q15102
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true

metaR SERGLNexR
is: SBO:0000185
fast: false
reactant: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
reversible: true
name: L-Serine/Glutamine reversible exchange
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110053#
product: MODEL1310110053#

metaM itp c
is: SBO:0000247
name: ITP(3-)
constant: false
is: CHEBI:57614
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
boundary condition: false
type: Species
is: HMDB00189

metaM g6p r
initial amount: NaN
is: HMDB01401
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: C00092
name: D-Glucose 6-phosphate
has only substance units: false
type: Species
is: CHEBI:61548
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
constant: false

metaM ha e
initial concentration: 1.0
constant: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
type: Species
is: CHEBI:16336
initial amount: NaN
name: hyaluronan
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR Htr
name: H transporter, endoplasmic reticulum
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110053#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true

metaR PIt7
kinetic law: MODEL1310110053#
name: phosphate transport in/out via three Na+ symporter
reversible: true
reactant: MODEL1310110053#
is described by: ECO:0000269
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
product: MODEL1310110053#
is: SBO:0000185
fast: false
type: Reaction

metaR AG13T12g
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110053#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110053#
reactant: MODEL1310110053#
modifier: MODEL1310110053#

metaR S6T9g
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
fast: false
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
reactant: MODEL1310110053#
product: MODEL1310110053#

metaR FAOXC18480m
is: SBO:0000176
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110053#
modifier: MODEL1310110053#
name: Beta oxidation of fatty acid
kinetic law: MODEL1310110053#

metaM tchola c
name: taurocholic acid
is: HMDB00036
constant: false
boundary condition: false
type: Species
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
is: SBO:0000247
is: CHEBI:36257
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR PCHOL HSter
kinetic law: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
reactant: MODEL1310110053#
type: Reaction
is: SBO:0000185
name: phosphatidylcholine scramblase
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_c4a3b807_70d2_4cd2_b0e8_bcf33231ff29
initial amount: NaN
type: Species
is: Q6P1K9
boundary condition: true
is: SBO:0000252
has only substance units: false
name: PANK2
is encoded by: hsa:80025
initial concentration: NaN
constant: false

metaM lnlncgcoa r
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
boundary condition: false
name: gamma-linolenoyl-CoA(4-)
has only substance units: false
is: HMDB06368
constant: false
initial amount: NaN
is: CHEBI:57363

metaM hista e
initial concentration: 1.0
name: histamium
is: SBO:0000247
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: CHEBI:58432
is: HMDB00870
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
constant: false

metaM duri n
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
name: 2'-deoxyuridine
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00012
is: CHEBI:16450
constant: false

metaM HC01231 m
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
initial amount: NaN
name: N-[(R)-pantothenoyl]-L-cysteinate
constant: false
boundary condition: false
type: Species
is: CHEBI:58480

http://identifiers.org/biomodels.db/MODEL1310110053#_311d8ce6_8435_4e80_a9da_88987c085ce5
is encoded by: hsa:5049
has only substance units: false
constant: false
is: A8DPS7
initial concentration: NaN
type: Species
boundary condition: true
name: PAFAH1B2
initial amount: NaN
is: SBO:0000252

metaR UGCG
reactant: MODEL1310110053#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.80
fast: false
name: Ceramide glucosyltransferase
product: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
reversible: false
modifier: MODEL1310110053#
is: SBO:0000176
is described by: ECO:0000000

metaR RE1534M
name: RE1534
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110053#
modifier: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110053#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM udpglcur r
has only substance units: false
is: HMDB00935
is: CHEBI:58052
name: UDP-D-glucuronate
constant: false
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: C00167
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_79b0098d_71b0_4fc8_ad26_a71284c56a9e
constant: false
initial amount: NaN
is encoded by: hsa:2544
boundary condition: true
is: SBO:0000252
type: Species
name: _2544_1_c
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_ed675c4c_eded_4e0b_bc28_98d1836ae072
is encoded by: hsa:10678
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q9NY97
is: SBO:0000252
initial concentration: NaN
type: Species
name: B3GNT2

metaM lnlncg l
is: CHEBI:32391
initial amount: NaN
is: HMDB03073
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
has only substance units: false
type: Species
constant: false
name: gamma-linolenate

metaR KCC2t
is described by: ECO:0000269
reversible: true
fast: false
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
name: K+-Cl- cotransporter (NH4+)
reactant: MODEL1310110053#
is: SBO:0000185
kinetic law: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#

metaR r0170
is: SBO:0000176
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
reactant: MODEL1310110053#
product: MODEL1310110053#
fast: false
type: Reaction
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.1.40
reversible: true
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
is described by: ECO:0000000

metaR PIt8
type: Reaction
name: phosphate transport in/out via Na+ symporter
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
is described by: ECO:0000006
fast: false
product: MODEL1310110053#
reactant: MODEL1310110053#
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#

metaM m3mpdol U c
is: CHEBI:37632
initial amount: NaN
notes: FORMULA: C1425H2340N20O370P20 CHARGE: -20
constant: false
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human uterine homolog
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_bb916e44_3cfc_490b_8969_e54d927fef8f
is: Q59FD4
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
name: HK1
type: Species
initial amount: NaN
is encoded by: hsa:3098

metaM ach c
boundary condition: false
name: acetylcholine
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00895
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
constant: false
type: Species
is: CHEBI:15355
initial concentration: 1.0

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaR CYSATB0tc
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Cysteine into the intestinal cells by ATB0 transporter
type: Reaction

metaM lnlnca e
name: alpha-linolenate
is: SBO:0000247
constant: false
is: HMDB01388
is: CHEBI:32387
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_df7335d1_6e1f_46bc_ac9b_3e8c7878d31a
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is encoded by: hsa:84890
initial amount: NaN
boundary condition: true
name: ADO
is: B3KXN9
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_b051b6dc_5f77_422a_8197_092ae6cc15eb
is encoded by: hsa:160287
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q6ZMR3
constant: false
is: SBO:0000252
initial amount: NaN
name: LDHAL6A
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_2666a9cf_7fd3_4db5_ac0f_e4c726b8e9cf
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5315
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: P14618
name: PKM2

metaR r2402
fast: false
is: SBO:0000185
product: MODEL1310110053#
reactant: MODEL1310110053#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is described by: ECO:0000000
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
type: Reaction

metaM lys L c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
name: L-lysinium(1+)
is: CHEBI:32551
boundary condition: false
has only substance units: false
constant: false
type: Species
is: HMDB00182

http://identifiers.org/biomodels.db/MODEL1310110053#_30163c26_4f86_4ba6_b3a6_28b74dc5214d
is: SBO:0000252
is: B7Z2M9
is encoded by: hsa:8525
initial amount: NaN
constant: false
type: Species
has only substance units: false
name: DGKZ
initial concentration: NaN
boundary condition: true

metaM dc2coa m
initial concentration: 1.0
has only substance units: false
type: Species
name: trans-Dec-2-enoyl-CoA
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
constant: false
initial amount: NaN
is: CHEBI:61406
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_9a2dd911_1b67_41de_963a_939a56e88e21
type: Species
initial concentration: NaN
has only substance units: false
name: CTPS1
is: P17812
is: SBO:0000252
is encoded by: hsa:1503
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_f59933ce_5e8a_4a3e_96ff_31273d3f4ac7
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4017
boundary condition: true
has only substance units: false
name: LOXL2
is: Q9Y4K0
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_5ae7f083_7818_4519_a0eb_3a37df6378d2
type: Species
is: P16219
is encoded by: hsa:35
constant: false
name: ACADS
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM tchola e
notes: FORMULA: C26H45NO7S CHARGE: 0
name: taurocholic acid
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB00036
has only substance units: false

metaM h2o n
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
constant: false
is: CHEBI:15377
name: water

metaM ctp c
is: C00063
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB00082
boundary condition: false
is: CHEBI:37563
name: CTP
type: Species

metaM HC01409 m
constant: false
name: Hexanoyl-CoA
is: SBO:0000247
is: CHEBI:27540
initial amount: NaN
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_e37270a0_b1dd_4ee4_af68_6ea6adab9d3a
is: SBO:0000252
name: AGPAT4
initial amount: NaN
constant: false
is encoded by: hsa:56895
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: Q9NRZ5

metaR DSAT
reversible: false
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
type: Reaction
is: SBO:0000176
name: dihydrosphingosine N-acyltransferase
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000000
fast: false

metaM hista c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: histamium
boundary condition: false
is: HMDB00870
type: Species
constant: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: CHEBI:58432

http://identifiers.org/biomodels.db/MODEL1310110053#_80ce6502_53f8_4035_8412_3d4a4e2b4ffc
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI972237
type: Species
name: _AI972237_1_c

http://identifiers.org/biomodels.db/MODEL1310110053#_082d174a_19c7_4fdd_8674_faacbbe3392b
initial concentration: NaN
is: Q02218
boundary condition: true
type: Species
constant: false
has only substance units: false
name: OGDH
is encoded by: hsa:4967
initial amount: NaN
is: SBO:0000252

metaM f6p c
type: Species
has only substance units: false
is: CHEBI:57579
is: C00085
initial concentration: 1.0
is: HMDB00124
is: SBO:0000247
name: D-Fructose 6-phosphate
boundary condition: false
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/3385

metaR r0242
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
product: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
is described by: ECO:0000000
kinetic law: MODEL1310110053#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.1
type: Reaction
modifier: MODEL1310110053#

metaR PCt
reversible: true
is: SBO:0000185
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
is version of: http://identifiers.org/ec-code/3.6.3.44
is described by: ECO:0000269
product: MODEL1310110053#
type: Reaction
name: phosphatidylcholine transporter

metaR N2M2NMASNtly
name: n2m2nmasn transport, extracellular to lysosome
is: SBO:0000185
fast: false
reactant: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM oaa m
type: Species
initial concentration: 1.0
is: CHEBI:16452
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: C00036
name: Oxaloacetate
is: HMDB00223
boundary condition: false

metaM 12ppd S c
name: (S)-propane-1,2-diol
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB06213
is: CHEBI:29002
boundary condition: false
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
has only substance units: false
constant: false

metaR LEUKTRE4t
fast: false
kinetic law: MODEL1310110053#
is described by: ECO:0000000
reactant: MODEL1310110053#
name: leukotriene E4 transport
product: MODEL1310110053#
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR r2092
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110053#
reversible: true
is: SBO:0000185
type: Reaction
modifier: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_38ef29f9_4744_4e8c_b0a9_30fc1cb5e839
has only substance units: false
is encoded by: hsa:127
constant: false
is: P08319
name: ADH4
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN

metaR r1958
reactant: MODEL1310110053#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110053#
reversible: false
fast: false
product: MODEL1310110053#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_d65b3077_3251_4d60_b44e_335347cf411d
constant: false
name: SLCO1A2
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:6579
is: SBO:0000252
is: P46721
has only substance units: false

metaM HC01401 m
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
is: CHEBI:27668
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: (S)-3-Hydroxydodecanoyl-CoA
initial concentration: 1.0
type: Species
constant: false
has only substance units: false

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaM lnlnca c
type: Species
initial amount: NaN
is: SBO:0000247
name: alpha-linolenate
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:32387
is: HMDB01388
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-

metaR F6Tg
name: glycoprotein 6-alpha-L-fucosyltransferase
kinetic law: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
modifier: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.68
type: Reaction
reversible: false

metaM cdp e
is: CHEBI:58069
initial amount: NaN
is: HMDB01546
constant: false
has only substance units: false
is: SBO:0000247
name: CDP(3-)
initial concentration: 1.0
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
type: Species
boundary condition: false

metaR DOLASNT Uer
is described by: ECO:0000000
product: MODEL1310110053#
reactant: MODEL1310110053#
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (uterus)
modifier: MODEL1310110053#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: PMID:8413235,PMID:9367678 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.119
reversible: false
type: Reaction
kinetic law: MODEL1310110053#

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaM pa hs c
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
name: phosphatidate(2-)
initial concentration: 1.0
type: Species
is: CHEBI:57739

metaR CO2tm
name: CO2 transport (diffusion), mitochondrial
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#

metaM udpgal g
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
type: Species
boundary condition: false
name: UDP-D-galactose(2-)
initial amount: NaN
has only substance units: false
is: HMDB00302
is: SBO:0000247
is: CHEBI:58439
constant: false
initial concentration: 1.0

metaR SPHS1Ptr
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
reactant: MODEL1310110053#
reversible: true
name: sphingosine-1-phosphate transport
product: MODEL1310110053#
kinetic law: MODEL1310110053#

metaR GGH 7THFe
is: SBO:0000176
modifier: MODEL1310110053#
reversible: false
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (7THF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110053#
fast: false
type: Reaction
reactant: MODEL1310110053#

metaM h2o l
is: HMDB02111
is: CHEBI:15377
boundary condition: false
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
name: water
initial concentration: 1.0

metaR SUCOAS1m
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
name: Succinate--CoA ligase (GDP-forming)
fast: false
reactant: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
type: Reaction
product: MODEL1310110053#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.4

metaR r1090
kinetic law: MODEL1310110053#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR FUMAC
product: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.7.1.2
is: SBO:0000176
type: Reaction
fast: false
reversible: false
name: fumarylacetoacetase

metaM so4 l
initial concentration: 1.0
constant: false
is: CHEBI:16189
type: Species
boundary condition: false
is: HMDB01448
name: sulfate
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059

http://identifiers.org/biomodels.db/MODEL1310110053#_c638dfb1_4c21_441c_b8c9_55a76e8feb63
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6392
name: SDHD
constant: false
is: O14521
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR r2093
reversible: true
product: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000185

metaR PTPATe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
product: MODEL1310110053#
is described by: ECO:0000134
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
name: PTPATe
fast: false
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110053#_eef38366_5ae3_4e5a_b497_84ddf599ed00
type: Species
name: _T83654_1_m
is: SBO:0000252
constant: false
is encoded by: hsa:T83654
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM g3m8masn r
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C88H147N2O70X CHARGE: 0
has only substance units: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: C05873
boundary condition: false

metaM o2s c
is: CHEBI:18421
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: HMDB02168
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
name: superoxide

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaM h2o m
constant: false
initial concentration: 1.0
type: Species
is: HMDB02111
is: SBO:0000247
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
name: H2O
is: CHEBI:15377
boundary condition: false
is: C00001

http://identifiers.org/biomodels.db/MODEL1310110053#_7fadf9f8_bd85_47a6_bb4c_39a0ea3fec82
initial amount: NaN
constant: false
name: PCBD1
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5092
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_9a87c4ab_6499_4e3d_8034_81d9cd7fbf8f
name: _NOS2A_1_e
has only substance units: false
initial concentration: NaN
is encoded by: hsa:NOS2A
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_0c280944_f1f9_4144_8a6e_b9f7edd8434e
initial concentration: NaN
name: ALPL
type: Species
is: B7Z4Y6
has only substance units: false
is encoded by: hsa:249
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN

metaM so4 m
has only substance units: false
constant: false
boundary condition: false
type: Species
is: HMDB01448
is: SBO:0000247
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
name: sulfate
is: CHEBI:16189
initial amount: NaN
initial concentration: 1.0

metaR ABTD
reversible: true
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
name: L-arabinitol 4-dehydrogenase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
fast: false
is: SBO:0000176
type: Reaction

metaR RE2666C
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#
name: RE2666
reversible: false
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:
is described by: ECO:0000000
type: Reaction

metaM itp e
is: HMDB00189
name: ITP(3-)
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:57614
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081

metaM lcts e
boundary condition: false
is: C00243
name: Lactose
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
is: HMDB00186
type: Species
is: CHEBI:17716
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_c3445e26_822b_4639_b4aa_cf2f2dfc5ead
is: SBO:0000252
is encoded by: hsa:9563
initial amount: NaN
is: O95479
type: Species
initial concentration: NaN
constant: false
name: H6PD
boundary condition: true
has only substance units: false

metaR DNDPt35m
name: dGDP transport via dADP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110053#
modifier: MODEL1310110053#
is: SBO:0000185
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
fast: false

metaM gdpfuc c
type: Species
constant: false
is: CHEBI:57984
name: GDP-L-fucose(2-)
has only substance units: false
is: HMDB01095
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325

metaR r0735
reversible: true
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110053#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110053#

metaR CERT1gt
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: true
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
is: SBO:0000185
modifier: MODEL1310110053#
is described by: ECO:0000304
fast: false
reactant: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
name: ceramide transport protein

metaR r2090
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110053#
modifier: MODEL1310110053#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110053#
product: MODEL1310110053#

metaR r1956
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110053#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: false
product: MODEL1310110053#
fast: false
type: Reaction

metaM cdp c
is: CHEBI:58069
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB01546
type: Species
is: C00112
has only substance units: false
initial concentration: 1.0
name: CDP
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_79861ecd_87f6_4da0_8618_7b2aae70c468
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: NOS1
boundary condition: true
is encoded by: hsa:4842
type: Species
is: B4DG68
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_1bf0624d_077f_4ead_a5a9_afb9ebf71a05
type: Species
boundary condition: true
is: P09848
initial concentration: NaN
name: LCT
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:3938
initial amount: NaN

metaR ALADGLNexR
kinetic law: MODEL1310110053#
name: L-alanine/glutamine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110053#
is described by: ECO:0000304
is: SBO:0000185
product: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
type: Reaction

metaR 2HCO3 NAt
type: Reaction
fast: false
modifier: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
reactant: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000269
kinetic law: MODEL1310110053#
is: SBO:0000185

metaR G5SADrm
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
reactant: MODEL1310110053#
fast: false
is: SBO:0000176
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
product: MODEL1310110053#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110053#
type: Reaction

metaR CDSm
is: SBO:0000176
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
fast: false
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.7.41
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110053#
name: phosphatidate cytidylyltransferase
reversible: false
product: MODEL1310110053#
kinetic law: MODEL1310110053#

metaM tymsf e
has only substance units: false
boundary condition: false
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
type: Species
initial amount: NaN
constant: false
is: HMDB06409
initial concentration: 1.0
name: Tyramine O-sulfate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_87a8284d_c040_4f59_90de_4d4a1d3f30d8
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1593
name: CYP27A1
is: Q02318
constant: false
boundary condition: true
type: Species
is: SBO:0000252

metaR RE2677G
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000176
reversible: false
product: MODEL1310110053#
is described by: ECO:0000000
name: RE2677
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:
fast: false

metaR EX arachcoa LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: arachidyl coenzyme A exchange
type: Reaction

metaM hs deg25 l
has only substance units: false
notes: FORMULA: C23H37O21 CHARGE: -1
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:16126
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR TRPt4
is: SBO:0000185
name: L-tryptophan transport in via sodium symport
reversible: false
type: Reaction
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
product: MODEL1310110053#
fast: false
reactant: MODEL1310110053#

metaM oxa m
constant: false
initial amount: NaN
is: HMDB02329
has only substance units: false
boundary condition: false
is: SBO:0000247
name: oxalate(2-)
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: CHEBI:30623
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_d6821161_7632_4ddc_a7be_203b6d9b15bc
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: NOS1
constant: false
is encoded by: hsa:4842
initial concentration: NaN
is: B4DG68
boundary condition: true
type: Species

metaM ficytC m
is: CHEBI:15991
initial concentration: 1.0
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
is: SBO:0000247
boundary condition: false
type: Species
constant: false
has only substance units: false
name: Ferricytochrome c
initial amount: NaN

metaM leuktrA4 c
initial amount: NaN
boundary condition: false
is: HMDB01337
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
type: Species
initial concentration: 1.0
is: CHEBI:57463
constant: false
name: leukotriene A4(1-)

metaM o2s e
name: superoxide
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:18421
is: HMDB02168

metaM ribflv c
name: Riboflavin
notes: FORMULA: C17H20N4O6 CHARGE: 0
has only substance units: false
is: HMDB00244
type: Species
is: CHEBI:3554
constant: false
initial concentration: 1.0
is: SBO:0000247
is: C00255
boundary condition: false
initial amount: NaN

metaM damp c
type: Species
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
is: HMDB00905
name: dAMP(2-)
is: CHEBI:58245
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_217f2ca2_9111_435d_ac98_778ae903de55
is encoded by: hsa:6817
boundary condition: true
is: P50225
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: SULT1A1

metaM datp m
is: CHEBI:61404
constant: false
is: HMDB01532
initial amount: NaN
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
name: dATP
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: C00131
type: Species
has only substance units: false

metaR r0022
is: SBO:0000176
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is version of: http://identifiers.org/ec-code/1.8.1.7
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
product: MODEL1310110053#
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_67f1d8f3_0d34_4b3c_999e_90bde141855c
has only substance units: false
constant: false
name: PPAP2A
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8611
is: SBO:0000252
type: Species
is: G3XA95

metaM ocdcea c
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1
name: octadecenoate (n-C18:1)
type: Species
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:0
boundary condition: false
is: HMDB00207
is: C00712

http://identifiers.org/biomodels.db/MODEL1310110053#_0b1c4a21_d549_4a9b_a2ab_6a037cd648c9
type: Species
initial concentration: NaN
is encoded by: hsa:2592
constant: false
initial amount: NaN
boundary condition: true
is: E7ET32
has only substance units: false
is: SBO:0000252
name: GALT

metaR r2085
type: Reaction
modifier: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110053#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110053#
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110053#

metaR r1587
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110053#
type: Reaction
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110053#

metaM ribflv e
initial concentration: 1.0
is: C00255
constant: false
name: Riboflavin
initial amount: NaN
is: HMDB00244
is: SBO:0000247
is: CHEBI:3554
notes: FORMULA: C17H20N4O6 CHARGE: 0
has only substance units: false
boundary condition: false
type: Species

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaR r2002
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110053#
product: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
type: Reaction
is: SBO:0000185
reversible: false
reactant: MODEL1310110053#

metaM oaa c
has only substance units: false
is: SBO:0000247
name: Oxaloacetate
boundary condition: false
initial concentration: 1.0
is: CHEBI:3338
constant: false
is: HMDB00223
is: C00036
initial amount: NaN
notes: FORMULA: C4H2O5 CHARGE: -2
type: Species

metaM cytd c
has only substance units: false
is: CHEBI:17562
type: Species
initial concentration: 1.0
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
constant: false
boundary condition: false
is: HMDB00089
is: SBO:0000247
initial amount: NaN
is: C00475
name: Cytidine

http://identifiers.org/biomodels.db/MODEL1310110053#_2b7e608d_c59c_4d5d_8b1f_5d9f996c4eab
has only substance units: false
is: Q9NY28
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
name: GALNT8
is encoded by: hsa:26290
type: Species

metaM pan4p e
is: CHEBI:47942
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: HMDB01416
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: Pantetheine 4'-phosphate
constant: false
is: C01134
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_a2aa2412_2d0a_4ac2_8dd1_f5ae333e6c85
name: SLC6A3
constant: false
is: Q01959
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6531
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_ccf90bb5_aa1c_4e72_9e11_f007251c877a
is: O75752
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:8706
initial concentration: NaN
name: B3GALNT1
type: Species
has only substance units: false
constant: false

metaR FAOXC80
type: Reaction
is: SBO:0000176
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of med/long chain fatty acid
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
modifier: MODEL1310110053#
is described by: ECO:0000269

metaR r0178
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
type: Reaction
reactant: MODEL1310110053#
product: MODEL1310110053#
fast: false
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
is version of: http://identifiers.org/ec-code/2.5.1.21
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110053#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_237e837f_6129_4768_944f_59b4eb1598e5
initial concentration: NaN
type: Species
is encoded by: hsa:224
boundary condition: true
is: P51648
constant: false
has only substance units: false
name: ALDH3A2
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_4352ab8a_b8f3_46c6_be6b_b7c723593fac
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: SLC38A5
type: Species
is: Q8WUX1
is encoded by: hsa:92745
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_c8e6628e_4668_4e82_9bb9_702d40e7c3c4
has only substance units: false
is: Q8TB61
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:347734
name: SLC35B2
initial amount: NaN

metaM tymsf c
name: Tyramine O-sulfate
initial amount: NaN
is: HMDB06409
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
is: SBO:0000247

metaR r2084
reactant: MODEL1310110053#
modifier: MODEL1310110053#
product: MODEL1310110053#
fast: false
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110053#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR SPH1Pte
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
kinetic law: MODEL1310110053#
fast: false
type: Reaction
name: sph1p transport
is described by: ECO:0000000
product: MODEL1310110053#
is: SBO:0000185
reversible: true

metaR r1588
type: Reaction
reactant: MODEL1310110053#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110053#
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110053#

metaR RE1520M
modifier: MODEL1310110053#
reversible: true
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110053#
name: RE1520
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110053#

metaR ICDHyrm
name: Isocitrate dehydrogenase (NADP+)
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
fast: false
reactant: MODEL1310110053#
is described by: ECO:0000269
type: Reaction

metaM idour e
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB02704
boundary condition: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
constant: false
initial amount: NaN
is: CHEBI:21338
initial concentration: 1.0
name: L-iduronate

metaR CHOLt4
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
name: choline, sodium cotransport
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
product: MODEL1310110053#
modifier: MODEL1310110053#
reversible: true
is described by: ECO:0000269
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110053#_2279be2c_eb7c_443a_9e63_8ef266502304
is: Q9Y617
initial concentration: NaN
boundary condition: true
name: PSAT1
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:29968
has only substance units: false
type: Species

metaM n2m2masn g
initial concentration: 1.0
type: Species
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
notes: FORMULA: C50H83N4O35X CHARGE: 0
has only substance units: false
constant: false
is: C11530
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM h2o g
is: HMDB02111
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15377
name: water

metaM acn13acngalgbside hs g
is: CHEBI:3338
is: SBO:0000247
is: HMDB00223
boundary condition: false
is: C00036
initial amount: NaN
name: sialyl (1,3) sialyl (2,6) galactosylgloboside
has only substance units: false
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
constant: false
initial concentration: 1.0
type: Species

metaM cholcoa c
is: CHEBI:57373
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB01374
constant: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
name: choloyl-CoA(4-)
initial concentration: 1.0

metaM aacoa m
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01484
is: CHEBI:57286
name: acetoacetyl-CoA(4-)
has only substance units: false
initial amount: NaN
type: Species
constant: false

metaM ocdcea e
type: Species
notes: FORMULA: C18H33O2 CHARGE: -1
is: SBO:0000247
constant: false
name: octadecenoate (n-C18:1)
has only substance units: false
is: HMDB00207
is: CHEBI:0
is: C00712
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM dolglcp U r
constant: false
initial amount: NaN
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
is: CHEBI:15812

http://identifiers.org/biomodels.db/MODEL1310110053#_7b4e2c07_7137_4223_97c5_48d6151c7588
initial concentration: NaN
is encoded by: hsa:57835
initial amount: NaN
name: SLC4A5
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
constant: false

metaM cytd e
name: Cytidine
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB00089
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: C00475
is: CHEBI:17562

metaR r1589
is: SBO:0000185
kinetic law: MODEL1310110053#
reversible: true
type: Reaction
reactant: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110053#
fast: false
is described by: ECO:0000000

metaM ctp m
is: CHEBI:37563
has only substance units: false
initial amount: NaN
name: CTP(4-)
is: SBO:0000247
type: Species
is: HMDB00082
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063

metaR r2083
is: SBO:0000185
modifier: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110053#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#

metaR CSNt
is described by: ECO:0000269
modifier: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
type: Reaction
kinetic law: MODEL1310110053#
reversible: true
is: SBO:0000185
name: cytosine transport via facilated diffusion
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_fa851c64_43d8_48d2_bda1_119eae357baa
is: Q01581
name: HMGCS1
is encoded by: hsa:3157
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_62de1b1e_812a_40dd_b7b1_40474ad444a6
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
name: ADH5
is: Q6IRT1
is: SBO:0000252
type: Species
is encoded by: hsa:128
boundary condition: true

metaM gly m
has only substance units: false
name: Glycine
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00123
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: SBO:0000247
constant: false
type: Species
is: CHEBI:15428
is: C00037

metaM datp n
name: dATP
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:61404
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: HMDB01532
is: C00131
type: Species

metaR r0384
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
reactant: MODEL1310110053#
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110053#
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_71cf5743_b2c5_4f64_9830_d615eb4faa7a
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
name: _AI694761_1_c
constant: false
is encoded by: hsa:AI694761
is: SBO:0000252
boundary condition: true

metaR ARACHt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
reactant: MODEL1310110053#
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_def965a5_b6d1_40fe_af06_6f9448d6482b
is: P20020
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:490
boundary condition: true
name: ATP2B1
initial concentration: NaN
constant: false

metaR G14T9g
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
modifier: MODEL1310110053#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38

http://identifiers.org/biomodels.db/MODEL1310110053#_bf264f08_45c4_4be1_a474_e8f53a2d26d4
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is: Q7LGC8
has only substance units: false
is encoded by: hsa:9469
name: CHST3
boundary condition: true
constant: false

metaR PROSTGI2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110053#
name: Prostaglandin I2 transport
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110053#
type: Reaction
product: MODEL1310110053#

metaM m2mn l
constant: false
boundary condition: false
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB06537
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
initial amount: NaN
initial concentration: 1.0

metaR RE0830N
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110053#
fast: false
is: SBO:0000176
reversible: true
name: RE0830
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/4.2.1.96
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
kinetic law: MODEL1310110053#
product: MODEL1310110053#

metaR r2082
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110053#
type: Reaction
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110053#
modifier: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM man1p c
is: SBO:0000247
is: CHEBI:35374
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
is: HMDB06330
has only substance units: false
constant: false
name: D-Mannose 1-phosphate

metaM arachdcoa c
boundary condition: false
type: Species
name: arachidonoyl-CoA(4-)
is: HMDB06523
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: CHEBI:57368
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247

metaM idour c
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: HMDB02704
constant: false
initial concentration: 1.0
is: CHEBI:21338
name: L-iduronate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_3eb2d0bd_5cee_415d_b810_8a98dc52a2f9
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:AA526438
has only substance units: false
constant: false
name: _AA526438_1_m
initial amount: NaN
boundary condition: true

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

metaM HC02210 e
has only substance units: false
is: CHEBI:34939
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
name: prostaglandin-d3
initial concentration: 1.0
constant: false

metaM guln r
is: HMDB03290
name: L-gulonate
initial concentration: 1.0
is: CHEBI:13115
is: SBO:0000247
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
constant: false

metaR r0385
kinetic law: MODEL1310110053#
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
is: SBO:0000176
reactant: MODEL1310110053#
reversible: false
product: MODEL1310110053#

metaR DGCHOLte
type: Reaction
fast: false
is described by: ECO:0000000
name: bile acid intracellular transport
is: SBO:0000185
reactant: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110053#
product: MODEL1310110053#

metaM h2o e
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:15377
initial concentration: 1.0
type: Species
is: C00001
is: HMDB02111
name: H2O
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_462f0b79_51a7_48ec_b9c7_e9be4f812f1a
has only substance units: false
boundary condition: true
constant: false
is: Q9Y5P6
name: GMPPB
initial concentration: NaN
type: Species
is encoded by: hsa:29925
is: SBO:0000252
initial amount: NaN

metaM acn13acngalgbside hs e
is: SBO:0000247
is: C00036
type: Species
is: CHEBI:3338
is: HMDB00223
has only substance units: false
name: sialyl (1,3) sialyl (2,6) galactosylgloboside
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_4cc195dc_2ab2_4b67_bc4d_54593d3992b7
initial concentration: NaN
is encoded by: hsa:AI191472
initial amount: NaN
name: _AI191472_1_c
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
type: Species

metaR SACCD4m
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.8
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.10 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
name: saccharopine dehydrogenase (NAD, L-glutamate forming), mitochondrial
is described by: ECO:0000269
reactant: MODEL1310110053#
fast: false
is: SBO:0000176
product: MODEL1310110053#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110053#_3c17654b_4a44_4134_85d0_03ad7a63866a
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is: Q16348
type: Species
is encoded by: hsa:6565
has only substance units: false
name: SLC15A2
initial amount: NaN

metaR r0596
product: MODEL1310110053#
is: SBO:0000176
modifier: MODEL1310110053#
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
type: Reaction
reactant: MODEL1310110053#
fast: false
reversible: false
is described by: ECO:0000000

metaR BALAtmr
reactant: MODEL1310110053#
fast: false
product: MODEL1310110053#
name: Beta-alanine reversible mitochondrial transport (diffusion)
kinetic law: MODEL1310110053#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
is: SBO:0000185

metaM fum m
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
boundary condition: false
is: SBO:0000247
is: CHEBI:29806
is: C00122
initial concentration: 1.0
constant: false
name: Fumarate
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00134

metaM oxa c
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: HMDB02329
name: oxalate(2-)
is: CHEBI:30623
has only substance units: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_71acb1bd_00ad_42a8_bc6b_dc16f3b53909
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:8776
name: MTMR1
initial amount: NaN
boundary condition: true
is: Q13613
constant: false

metaM no c
initial concentration: 1.0
is: HMDB03378
constant: false
is: SBO:0000247
has only substance units: false
name: Nitric oxide
boundary condition: false
initial amount: NaN
type: Species
is: C00533
is: CHEBI:16480
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533

metaM cys L e
name: L-cysteine
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:17561
is: HMDB00574
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_dcffab98_286e_491c_a1cc_8651eea50a12
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2348
name: FOLR1
type: Species
is: P15328
constant: false
boundary condition: true

metaR r2089
product: MODEL1310110053#
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110053#
reactant: MODEL1310110053#

metaR ARGtm
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
fast: false
name: arginine mitochondrial transport via ornithine carrier
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110053#
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_ed826ff9_9461_48fd_92f2_f9a9dcaa2fd9
constant: false
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
name: SLC20A1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6574
is: Q8WUM9

http://identifiers.org/biomodels.db/MODEL1310110053#_40fee74f_d91a_4f4c_bb14_4c63af0924f2
initial amount: NaN
constant: false
name: _AA502753_1_m
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:AA502753
initial concentration: NaN

metaM itp n
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
name: ITP(3-)
is: CHEBI:57614
is: HMDB00189
is: SBO:0000247
boundary condition: false

metaM cdp m
has only substance units: false
initial amount: NaN
is: HMDB01546
name: CDP(3-)
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
constant: false
boundary condition: false
is: CHEBI:58069

metaM ctp e
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
name: CTP(4-)
type: Species
initial amount: NaN
is: CHEBI:37563
is: HMDB00082

metaM nrpphrsf c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/123747
boundary condition: false
type: Species
initial amount: NaN
is: HMDB02062
constant: false
name: Sulfate derivative of norepinephrine
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110053#_66ffe853_71e4_4f7f_a9e8_1e151eb4eeed
is: SBO:0000252
has only substance units: false
name: _H53099_1_m
is encoded by: hsa:H53099
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_ef211a13_006d_457b_92ad_9b5e5e0870b6
is: Q63HM1
boundary condition: true
is encoded by: hsa:125061
constant: false
initial concentration: NaN
type: Species
name: AFMID
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM lnlncg r
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: SBO:0000247
constant: false
type: Species
is: HMDB03073
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:32391
name: gamma-linolenate

metaM arachcrn c
boundary condition: false
constant: false
type: Species
name: arachidyl carnitine
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
has only substance units: false
is: HMDB06460

metaR ACHEe
is: SBO:0000176
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
reversible: false
name: Acetylcholinesterase
reactant: MODEL1310110053#
type: Reaction
is described by: ECO:0000269
fast: false
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.1.1.7
modifier: MODEL1310110053#

metaR PSDm hs
name: Phosphatidylserine decarboxylase
is version of: http://identifiers.org/ec-code/4.1.1.65
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
product: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110053#_8e4da49e_4a20_4523_bf48_2b2aaa962dd3
constant: false
is encoded by: hsa:38
type: Species
name: ACAT1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: P24752
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_010f87b8_7bd6_4bd3_938c_14dc402e8662
name: TALDO1
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
is: P37837
initial concentration: NaN
constant: false
is encoded by: hsa:6888
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_8e187255_f21f_46f3_a3a4_6aa9b1db4048
is: SBO:0000252
constant: false
type: Species
name: ST3GAL3
initial amount: NaN
is encoded by: hsa:6487
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR PIPLC
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.4.11
type: Reaction
fast: false
reactant: MODEL1310110053#
product: MODEL1310110053#
name: phosphatidylinositol phospholipase C
reversible: false
is: SBO:0000176
modifier: MODEL1310110053#

metaR DNDPt13m
name: dADP transport via ATP antiport
type: Reaction
kinetic law: MODEL1310110053#
is described by: ECO:0000269
reactant: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
fast: false
product: MODEL1310110053#
is: SBO:0000185

metaM acald c
boundary condition: false
has only substance units: false
is: HMDB00990
type: Species
constant: false
name: acetaldehyde
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: CHEBI:15343
initial concentration: 1.0

metaR r2088
type: Reaction
reactant: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110053#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
kinetic law: MODEL1310110053#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_2c3fafe1_f2e8_4fea_8efb_e7813c4e4d8d
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:728441
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
name: GGT2

metaR TDCHOLAtx
reversible: true
is described by: ECO:0000000
product: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
type: Reaction
name: bile acid intracellular transport

metaM ach e
initial amount: NaN
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial concentration: 1.0
is: CHEBI:15355
has only substance units: false
is: SBO:0000247
type: Species
name: acetylcholine
boundary condition: false
constant: false
is: HMDB00895

http://identifiers.org/biomodels.db/MODEL1310110053#_b270c784_b27a_41ce_808c_5f59834c1255
type: Species
initial concentration: NaN
has only substance units: false
is: Q16720
is encoded by: hsa:492
boundary condition: true
is: SBO:0000252
constant: false
name: ATP2B3
initial amount: NaN

metaM h2o c
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: H2O
type: Species
is: CHEBI:3303
is: C00001
has only substance units: false
is: HMDB02111
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110053#_5a91c06b_6b3d_4da9_a3a9_de9789fa0e51
initial amount: NaN
is: O15120
constant: false
has only substance units: false
name: AGPAT2
is encoded by: hsa:10555
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_07f2d55c_9b44_471d_9374_f126b8804675
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:5805
type: Species
has only substance units: false
constant: false
is: SBO:0000252
name: PTS
is: Q03393

metaM oxa e
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB02329
is: SBO:0000247
is: CHEBI:30623
initial amount: NaN
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
name: oxalate(2-)
has only substance units: false

metaR AG13T2g
is described by: ECO:0000000
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
kinetic law: MODEL1310110053#
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
modifier: MODEL1310110053#
product: MODEL1310110053#

metaM L2aadp c
is: CHEBI:58672
constant: false
name: L-2-aminoadipate(1-)
is: HMDB00510
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
type: Species

metaM acn13acngalgbside hs c
initial concentration: 1.0
is: HMDB00223
name: sialyl (1,3) sialyl (2,6) galactosylgloboside
initial amount: NaN
boundary condition: false
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: C00036
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:3338
type: Species

metaM no e
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
initial concentration: 1.0
name: Nitric oxide
boundary condition: false
has only substance units: false
is: CHEBI:16480
initial amount: NaN
is: HMDB03378
constant: false
is: SBO:0000247
is: C00533
type: Species

metaR r2087
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110053#

metaR RE2541E
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.31
modifier: MODEL1310110053#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110053#
type: Reaction
name: RE2541
reactant: MODEL1310110053#
product: MODEL1310110053#

metaM dhor S c
name: (S)-dihydroorotate
is: SBO:0000247
constant: false
is: CHEBI:30864
is: HMDB03349
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
type: Species
boundary condition: false

metaM anth c
constant: false
initial amount: NaN
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
type: Species
is: CHEBI:16567
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB01123
name: anthranilate
has only substance units: false

metaM 4hpro LT m
is: CHEBI:18095
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
initial concentration: 1.0
is: SBO:0000247
name: trans-4-hydroxy-L-proline
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00725
constant: false

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaR BETALDHxm
name: betaine-aldehyde dehydrogenase, mitochondrial
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 2 AUTHORS: PMID:15321791 NOTES:MM
reactant: MODEL1310110053#
is described by: ECO:0000000
fast: false
is: SBO:0000176
kinetic law: MODEL1310110053#
type: Reaction
reversible: false

metaM nrpphrsf e
type: Species
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: Sulfate derivative of norepinephrine
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
is: http://identifiers.org/pubchem.compound/123747
is: HMDB02062

metaM dcmp c
has only substance units: false
is: CHEBI:57566
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
initial concentration: 1.0
initial amount: NaN
is: HMDB01202
constant: false
boundary condition: false
is: C00239
type: Species
name: dCMP
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_d172e0ad_7efe_406b_a14a_1d51fab7f90f
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: Q9HBH5
name: RDH14
is: SBO:0000252
type: Species
is encoded by: hsa:57665
initial concentration: NaN

metaR r0021
reversible: true
is: SBO:0000176
type: Reaction
modifier: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
is described by: ECO:0000000
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is version of: http://identifiers.org/ec-code/3.6.1.5
product: MODEL1310110053#
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#

metaR IDOURtly
name: iduronate transport into lysososme
is: SBO:0000185
reactant: MODEL1310110053#
fast: false
product: MODEL1310110053#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
modifier: MODEL1310110053#

metaM 3aib D c
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
name: D-3-Amino-isobutanoate
has only substance units: false
is: HMDB02299
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: C03265
boundary condition: false
initial concentration: 1.0

metaM 2mop c
name: 2-methyl-3-oxopropanoate
is: CHEBI:57700
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: HMDB01172
has only substance units: false
constant: false
initial concentration: 1.0

metaR r0179
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
is described by: ECO:0000000
is: SBO:0000176
reversible: true
type: Reaction
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.27
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
product: MODEL1310110053#

metaM HC01399 m
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
name: (S)-3-Hydroxytetradecanoyl-CoA
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:27466

metaR URIt5le
is described by: ECO:0000134
reversible: false
reactant: MODEL1310110053#
modifier: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
name: uridine transport in via sodium symport (1:2)
kinetic law: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185

metaR r0504
reversible: true
is described by: ECO:0000000
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
product: MODEL1310110053#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.3.3.10
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
modifier: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#

metaR CYANt
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
product: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
name: Cyanide transport via diffusion (extracellular to cytosol)
reversible: true

metaR r0614
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
kinetic law: MODEL1310110053#
is: SBO:0000176
reversible: true
fast: false
reactant: MODEL1310110053#
type: Reaction
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
product: MODEL1310110053#
is described by: ECO:0000000

metaM pan4p m
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB01416
is: SBO:0000247
type: Species
is: CHEBI:47942
initial amount: NaN
name: pantetheine 4'-phosphate(2-)

metaM dopasf c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
is: HMDB06275
has only substance units: false
is: CHEBI:37946
is: SBO:0000247
name: dopamine 3-O-sulfate

metaM anth e
boundary condition: false
name: anthranilate
is: HMDB01123
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
is: CHEBI:16567
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
type: Species

metaM glx c
is: CHEBI:36655
has only substance units: false
name: glyoxylate
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
initial concentration: 1.0
is: SBO:0000247
is: HMDB00119
type: Species
initial amount: NaN
constant: false
boundary condition: false

metaM ocdcea l
name: oleate
initial amount: NaN
is: SBO:0000247
is: HMDB00207
type: Species
constant: false
is: CHEBI:30823
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9- HEPATONET_1.0_ABBREVIATION: HC00510 EHMN_ABBREVIATION: C00712
has only substance units: false
initial concentration: 1.0

metaR r2377
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
type: Reaction
product: MODEL1310110053#

metaR B3GALT3g
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
name: Beta-1,3-galactosyltransferase 3
fast: false
type: Reaction
modifier: MODEL1310110053#
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.79
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110053#
reversible: false

metaR r2510
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000185
name: Utilized transport
type: Reaction
is described by: ECO:0000000

metaR r0494
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reversible: true
product: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_01e80597_b685_4a85_8359_3f11e6fe3ddd
name: CDIPT
type: Species
is: A8K3L7
is encoded by: hsa:10423
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR EX thymd LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymidine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_10907b4c_d823_4190_a974_66b06f773497
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:4709
is: Q6IB80
constant: false
has only substance units: false
name: NDUFB3
initial concentration: NaN
initial amount: NaN

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_59faa2e6_d154_4f67_b759_408a784a6dbd
is encoded by: hsa:4860
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is: P00491
has only substance units: false
boundary condition: true
constant: false
name: PNP

http://identifiers.org/biomodels.db/MODEL1310110053#_4e89f148_2d1b_49e5_bfee_3b8a3a076c69
is: O75251
is: SBO:0000252
constant: false
type: Species
boundary condition: true
is encoded by: hsa:374291
name: NDUFS7
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM ksi pre34 g
has only substance units: false
is: CHEBI:58053
initial concentration: 1.0
type: Species
is: HMDB00175
boundary condition: false
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
is: SBO:0000247
is: C00130
initial amount: NaN
constant: false
name: keratan sulfate I biosynthesis, precursor 34

metaR r2378
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
product: MODEL1310110053#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#

metaM na1 e
name: Sodium
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: C01330
type: Species
is: HMDB00588
constant: false
notes: FORMULA: Na CHARGE: 1
boundary condition: false
has only substance units: false
is: CHEBI:4541

metaR ASCBt4
name: L-ascorbate transport via proton symport
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
modifier: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000269
is: SBO:0000185

metaM ppa e
initial concentration: 1.0
is: CHEBI:17272
type: Species
has only substance units: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
boundary condition: false
is: HMDB00237
initial amount: NaN
name: propionate
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_19591cdd_39dc_40bc_83d3_b9c2fc1fdc24
constant: false
is: P31213
is encoded by: hsa:6716
initial amount: NaN
initial concentration: NaN
name: SRD5A2
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_a3f96fc6_b34d_4c32_a6b2_abdc0c8c4cf6
boundary condition: true
constant: false
type: Species
is: Q9BZX2
initial amount: NaN
name: UCK2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:7371
is: SBO:0000252

metaR r0502
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
is: SBO:0000176
kinetic law: MODEL1310110053#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.113
reactant: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
fast: false
modifier: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_c5a80bfb_74ad_4b87_b664_0936f5ddf630
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q9Y673
boundary condition: true
initial concentration: NaN
name: ALG5
constant: false
is encoded by: hsa:29880

metaR r0591
product: MODEL1310110053#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
modifier: MODEL1310110053#
reversible: true
fast: false

metaR r1580
kinetic law: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110053#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_21f65fd5_6279_4782_9429_bc467b412806
is encoded by: hsa:343
type: Species
boundary condition: true
constant: false
is: O94778
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: AQP8

http://identifiers.org/biomodels.db/MODEL1310110053#_b30ad036_b0d8_4d8b_9d28_a935c5a93465
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:AA081045
has only substance units: false
boundary condition: true
name: _AA081045_1_m
is: SBO:0000252
initial concentration: NaN

metaM T antigen g
boundary condition: false
notes: FORMULA: C14H24NO10X CHARGE: 0
is: CHEBI:22783
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
name: T antigen (core 1)

http://identifiers.org/biomodels.db/MODEL1310110053#_9e54eb10_e60e_473a_8c3c_e11698ebdf6f
constant: false
is: P07864
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
name: LDHC
initial amount: NaN
is encoded by: hsa:3948
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_de832d20_70a1_44a9_a848_0b702b8eb214
is: SBO:0000252
is encoded by: hsa:5332
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: E2QRH8
constant: false
name: PLCB4
boundary condition: true

metaM dopasf e
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB06275
is: CHEBI:37946
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
initial amount: NaN
has only substance units: false
name: dopamine 3-O-sulfate

metaM dcmp n
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:57566
name: dCMP(2-)
boundary condition: false
constant: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
has only substance units: false
is: HMDB01202
is: SBO:0000247

metaR DOLPMT4 Uer
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
reversible: false
reactant: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110053#
product: MODEL1310110053#
type: Reaction

metaR TSULt4 3
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110053#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
product: MODEL1310110053#
reactant: MODEL1310110053#
name: thiosulfate transport via sodium symport
modifier: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_b157e81e_24c0_4830_a405_92f5fbd650f7
is: Q96RV2
is encoded by: hsa:3038
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
name: HAS3
initial concentration: NaN
has only substance units: false

metaM cys L c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: CHEBI:17561
initial amount: NaN
type: Species
name: L-cysteine
boundary condition: false
is: HMDB00574
initial concentration: 1.0
constant: false

metaM cytd m
constant: false
initial amount: NaN
is: HMDB00089
is: CHEBI:17562
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: SBO:0000247
name: cytidine
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0

metaR r2379
product: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
reactant: MODEL1310110053#
reversible: true
type: Reaction
kinetic law: MODEL1310110053#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_807db94a_0a5e_4d13_b952_99eb17031fac
name: B3GALNT1
initial concentration: NaN
type: Species
is: Q49AT3
boundary condition: true
has only substance units: false
is encoded by: hsa:8706
constant: false
initial amount: NaN
is: SBO:0000252

metaM lnlncgcoa c
constant: false
name: gamma-linolenoyl-CoA(4-)
has only substance units: false
is: HMDB06368
boundary condition: false
is: CHEBI:57363
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_ba0e7e02_6c98_435e_8d0e_c5965ffab8b2
initial amount: NaN
has only substance units: false
name: ALDH2
is: P05091
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:217
initial concentration: NaN

metaR r0594
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
fast: false
product: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true
modifier: MODEL1310110053#
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110053#
is: SBO:0000176

metaM C02528 r
initial concentration: 1.0
is: HMDB00518
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
type: Species
boundary condition: false
name: chenodeoxycholate
initial amount: NaN
has only substance units: false
is: CHEBI:36234
constant: false
is: SBO:0000247

metaM kynate c
name: kynurenate
is: CHEBI:58454
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00715

metaM idour l
is: HMDB02704
type: Species
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:21338
initial concentration: 1.0
is: SBO:0000247
name: L-iduronate
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1

metaM hLkynr c
constant: false
has only substance units: false
is: CHEBI:17380
initial amount: NaN
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB11631
name: 3-hydroxy-L-kynurenine

metaM dttp m
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: SBO:0000247
name: dTTP
initial amount: NaN
is: C00459
is: HMDB01342
constant: false
boundary condition: false
is: CHEBI:37568

metaR r1581
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110053#
is: SBO:0000185
kinetic law: MODEL1310110053#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110053#

metaM ksii core2 pre3 g
initial amount: NaN
boundary condition: false
constant: false
name: keratan sulfate II biosynthesis, precursor 3
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C47H76N4O33X CHARGE: -1
is: CHEBI:58053
is: HMDB00175
is: C00130

metaM cyan c
initial amount: NaN
boundary condition: false
is: CHEBI:18407
name: hydrogen cyanide
is: HMDB02084
has only substance units: false
constant: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR GLCNACASE3ly
product: MODEL1310110053#
reactant: MODEL1310110053#
reversible: false
kinetic law: MODEL1310110053#
is described by: ECO:0000000
name: alpha-N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.50
modifier: MODEL1310110053#

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaM cdp n
name: CDP(3-)
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01546
is: CHEBI:58069
type: Species

metaM ksi pre6 g
is: HMDB00175
has only substance units: false
is: C00130
is: SBO:0000247
notes: FORMULA: C107H174N7O80SX CHARGE: -2
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: CHEBI:58053
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 6

metaR ST6GALNAC21
is: SBO:0000176
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.99.7
modifier: MODEL1310110053#
name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
notes: GENE_ASSOCIATION: (10610.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.7 Confidence Level: 2 AUTHORS: NOTES:NJ
fast: false
reactant: MODEL1310110053#
type: Reaction
reversible: false
kinetic law: MODEL1310110053#
is described by: ECO:0000304

metaR r0497
is: SBO:0000176
reversible: true
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.2.4.2
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
type: Reaction
product: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
is described by: ECO:0000000
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39

metaM na1 c
name: Sodium
is: C01330
is: CHEBI:4541
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00588
constant: false
initial amount: NaN
notes: FORMULA: Na CHARGE: 1

http://identifiers.org/biomodels.db/MODEL1310110053#_08bb31c7_9459_44a8_8c0e_9e1aa70bc53d
constant: false
is encoded by: hsa:8310
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: O15254
is: SBO:0000252
name: ACOX3

http://identifiers.org/biomodels.db/MODEL1310110053#_6d9eb584_3a24_4736_8909_fecde83bc03f
is: O75610
initial concentration: NaN
name: LEFTY1
is: SBO:0000252
constant: false
is encoded by: hsa:10637
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_a63c594d_c49c_40fd_b97e_405a5cc5a3e9
has only substance units: false
is: O00154
initial concentration: NaN
boundary condition: true
constant: false
name: ACOT7
is encoded by: hsa:11332
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_225d27ab_2b8d_4a9a_ad8b_c707a2492d53
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5373
constant: false
is: SBO:0000252
boundary condition: true
is: O15305
type: Species
name: PMM2

http://identifiers.org/biomodels.db/MODEL1310110053#_d5d8603c_2740_4408_9779_d89c189dfa14
boundary condition: true
name: HEPH
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: E9PHN8
is encoded by: hsa:9843

metaR PGCD
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26227.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.95
product: MODEL1310110053#
name: phosphoglycerate dehydrogenase
reactant: MODEL1310110053#
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110053#
reversible: false
modifier: MODEL1310110053#

metaM pa hs m
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
boundary condition: false
is: CHEBI:57739
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
name: phosphatidate(2-)
is: SBO:0000247
has only substance units: false

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_eb52cdc3_dafa_4225_9d0e_98ba84270801
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10861
name: SLC26A1
type: Species
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_9ac27042_00f1_4306_898e_222d6f0016bf
boundary condition: true
type: Species
initial concentration: NaN
name: _HG2846_HT2983_1_m
has only substance units: false
is: SBO:0000252
is encoded by: hsa:HG2846-HT2983
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_e1bbf392_4367_42fa_96ad_45877de439ed
name: ATIC
is encoded by: hsa:471
boundary condition: true
initial amount: NaN
type: Species
is: P31939
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false

metaR EX pect LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectins
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_490433e3_4b1d_4617_bdf1_b035db017c4c
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: _D29675_1_e
is encoded by: hsa:D29675
constant: false
is: SBO:0000252

metaR RTOTAL2t
product: MODEL1310110053#
name: RTOTAL2 transport
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110053#

metaR r1696
kinetic law: MODEL1310110053#
name: Y+LAT2 Utilized transport
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: false
fast: false
is: SBO:0000185
reactant: MODEL1310110053#
modifier: MODEL1310110053#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_37816183_1543_4314_8594_82831d735bf8
type: Species
initial concentration: NaN
initial amount: NaN
name: HMGCL
is encoded by: hsa:3155
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is: Q6IBC0

metaM hs deg10 l
is: CHEBI:15748
is: HMDB00127
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
name: heparan sulfate, degradation product 10
constant: false
initial concentration: 1.0
initial amount: NaN

metaM pail4p hs c
boundary condition: false
has only substance units: false
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
is: CHEBI:58178
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
type: Species
constant: false

metaM HC02204 e
boundary condition: false
is: CHEBI:27624
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
name: prostaglandin-b1

http://identifiers.org/biomodels.db/MODEL1310110053#_7b88c4db_a28b_41a6_bbb5_69f8ffb2f42f
has only substance units: false
constant: false
type: Species
boundary condition: true
name: ACAD11
is encoded by: hsa:84129
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q709F0

metaR S23T3g
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.99.6
product: MODEL1310110053#
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
type: Reaction
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110053#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110053#_7b1ca9f5_d3ea_4c63_9acf_df02ae8ee002
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:100128062
constant: false
name: _100128062_1_m
initial concentration: NaN
has only substance units: false
type: Species

metaR DURIPP
product: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000176
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
reversible: true
name: deoxyuridine phosphorylase
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.3
modifier: MODEL1310110053#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_7baba7d4_b9ee_4f32_8a90_cc288dd816c6
is encoded by: hsa:1349
is encoded by: hsa:1339
has part: Q96KJ9
has part: Q7GXZ8
has part: Q6YFQ2
has part: P20674
initial concentration: NaN
type: Species
is encoded by: hsa:1350
is encoded by: hsa:1340
has part: P15954
constant: false
boundary condition: true
is encoded by: hsa:1346
is encoded by: hsa:1347
is encoded by: hsa:1337
has part: Q53XN1
is encoded by: hsa:341947
has part: P00414
has part: Q8TF08
is encoded by: hsa:125965
has part: Q53YB7
is encoded by: hsa:9167
has part: P24310
has part: Q7Z4L0
is encoded by: hsa:1345
is encoded by: hsa:4514
is encoded by: hsa:1327
has part: P24311
has part: P14854
initial amount: NaN
has part: P12074
has only substance units: false
has part: Q6FGA0
has part: P09669
is encoded by: hsa:9377
is: SBO:0000297
has part: Q7GXY8
is encoded by: hsa:170712
has part: H0UI06
is encoded by: hsa:1329
is encoded by: hsa:1351
is encoded by: hsa:84701
is encoded by: hsa:4512
has part: P13073
is encoded by: hsa:4513
has part: Q02221
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A

metaR GLYt7 211 r
name: glycine reversible transport via sodium and chloride symport (2:1:1)
reversible: true
is: SBO:0000185
reactant: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000269
type: Reaction
fast: false
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110053#_eefa1b00_0b2a_48a3_8d0a_957c965704d9
name: B3GALT5
constant: false
is encoded by: hsa:10317
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q9Y2C3

metaR 3MOPt2im
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000185
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction

metaR DOLPMT1 Uer
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
type: Reaction
product: MODEL1310110053#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.258
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
reversible: false
modifier: MODEL1310110053#

metaR r0027
reversible: true
is: SBO:0000176
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.39
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_3a884114_5a0b_445e_a980_c0a43478aeea
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: O14732
is encoded by: hsa:3613
has only substance units: false
name: IMPA2

metaM tchola x
is: SBO:0000247
is: CHEBI:36257
initial concentration: 1.0
initial amount: NaN
is: HMDB00036
name: taurocholate
constant: false
boundary condition: false
type: Species
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_c4c95dd0_0446_43c0_bac0_9cbe907d78cf
name: SLC6A4
type: Species
is: P31645
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6532
initial concentration: NaN

metaM ctp n
boundary condition: false
constant: false
is: SBO:0000247
name: CTP(4-)
has only substance units: false
initial concentration: 1.0
is: CHEBI:37563
initial amount: NaN
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
type: Species
is: HMDB00082

metaR 2DR1PP
reversible: false
reactant: MODEL1310110053#
name: 2-deoxy-D-ribose 1-phosphate phosphorylase
product: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD

metaM 2mop m
is: HMDB01172
boundary condition: false
type: Species
is: CHEBI:57700
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: SBO:0000247
initial amount: NaN
constant: false
name: 2-methyl-3-oxopropanoate
has only substance units: false
initial concentration: 1.0

metaM arachdcoa m
constant: false
is: HMDB06523
boundary condition: false
initial amount: NaN
is: CHEBI:57368
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: arachidonoyl-CoA(4-)
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
type: Species

metaM 4hpro LT e
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
boundary condition: false
is: SBO:0000247
has only substance units: false
name: trans-4-hydroxy-L-proline
initial concentration: 1.0
initial amount: NaN
is: HMDB00725
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_02c2af3b_9b9b_4d37_b1f2_a885345a950e
is encoded by: hsa:AI653169
is: SBO:0000252
name: _AI653169_1_c
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
type: Species

metaM L2aadp6sa m
type: Species
is: HMDB01263
boundary condition: false
has only substance units: false
name: L-allysine
initial concentration: 1.0
is: CHEBI:17917
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
is: SBO:0000247
constant: false
initial amount: NaN

metaM ksii core2 pre9 g
name: keratan sulfate II biosynthesis, precursor 9
is: CHEBI:28067
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0

metaR r1584
reactant: MODEL1310110053#
product: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110053#

metaM dttp n
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
name: dttp[n]
initial concentration: 1.0
notes: FORMULA: CHARGE: 0
is: HMDB01342
has only substance units: false
type: Species

metaM ach n
constant: false
is: CHEBI:15355
is: SBO:0000247
initial amount: NaN
name: acetylcholine
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
has only substance units: false
type: Species
is: HMDB00895
initial concentration: 1.0
boundary condition: false

metaR MACACI
type: Reaction
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000269
name: maleylacetoacetate isomerase
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.18

metaM fum c
is: HMDB00134
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
constant: false
is: SBO:0000247
type: Species
boundary condition: false
is: C00122
is: CHEBI:29806
name: Fumarate
has only substance units: false

metaM hs deg18 l
type: Species
boundary condition: false
constant: false
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
is: SBO:0000247
has only substance units: false
is: HMDB01352
initial concentration: 1.0
is: CHEBI:17180
initial amount: NaN
name: heparan sulfate, degradation product 18

metaR NMNS
reversible: false
name: NMN synthetase
is described by: ECO:0000134
product: MODEL1310110053#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:19513556 NOTES:
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_522b8e01_e636_4a09_9c77_feb59939b6f6
is encoded by: hsa:275
initial amount: NaN
name: AMT
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: P48728
constant: false
type: Species

metaM dutp c
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial amount: NaN
boundary condition: false
is: CHEBI:17625
name: dUTP
is: C00460
constant: false
is: HMDB01191
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM dcyt e
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial concentration: 1.0
boundary condition: false
name: Deoxycytidine
type: Species
is: HMDB00014
is: CHEBI:15698
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: C00881

metaM ocdcea r
notes: FORMULA: C18H33O2 CHARGE: -1
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: C00712
is: HMDB00207
is: CHEBI:0
is: SBO:0000247
name: octadecenoate (n-C18:1)
type: Species

metaM m8masn r
notes: FORMULA: C70H117N2O55X CHARGE: 0
constant: false
has only substance units: false
initial concentration: 1.0
is: C05876
is: SBO:0000247
initial amount: NaN
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
boundary condition: false

metaR FRDPtr
kinetic law: MODEL1310110053#
is: SBO:0000185
name: lipid, flip-flop intracellular transport
product: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
fast: false
reversible: true
reactant: MODEL1310110053#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_f4e3d1c7_48c2_45bb_acbb_0462ba93a02b
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
name: AKR1A1
initial concentration: NaN
is encoded by: hsa:10327
has only substance units: false

metaR ITCOALm
reversible: true
reactant: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
type: Reaction
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110053#
is described by: ECO:0000212
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.5

http://identifiers.org/biomodels.db/MODEL1310110053#_47fd5ac0_4b12_4bdd_9c8d_b5c648201b11
is: Q06210
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
name: GFPT1
is encoded by: hsa:2673
has only substance units: false

metaM thr L e
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: HMDB00167
is: CHEBI:16857
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
constant: false
name: L-threonine
initial concentration: 1.0

metaR r1585
reactant: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_f534de11_be24_48fb_a857_d783af926b05
is encoded by: hsa:6185
initial concentration: NaN
initial amount: NaN
is: P04844
name: RPN2
constant: false
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR r0616
is described by: ECO:0000000
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
fast: false
reactant: MODEL1310110053#
type: Reaction
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
modifier: MODEL1310110053#
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_711fb77b_0fb2_4128_99a7_b588793a7ba2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:29920
initial concentration: NaN
constant: false
has only substance units: false
type: Species
name: PYCR2
initial amount: NaN
is: Q96C36

metaR S6T12g
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110053#_6cb15d76_2f5d_4ed5_85e0_6251c0cb95a7
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
name: SLC35C1
is: B3KQH0
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:55343

metaR r0590
is: SBO:0000176
modifier: MODEL1310110053#
reversible: false
product: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR DCK2n
type: Reaction
kinetic law: MODEL1310110053#
name: Deoxycytidine kinase, nuclear (UTP)
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.74
is described by: ECO:0000269
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
product: MODEL1310110053#
reversible: true
reactant: MODEL1310110053#

metaR r2511
product: MODEL1310110053#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110053#
reversible: true
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110053#

metaM pa hs r
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: phosphatidate(2-)
constant: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
type: Species
is: CHEBI:57739

metaR RE3627M
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE3627
modifier: MODEL1310110053#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
product: MODEL1310110053#
reversible: true
kinetic law: MODEL1310110053#

metaR S6TASE2ly
reversible: true
fast: false
product: MODEL1310110053#
reactant: MODEL1310110053#
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110053#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_be167758_143c_44a9_b063_551fe67757b5
initial amount: NaN
is encoded by: hsa:AI697028
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: _AI697028_1_e

http://identifiers.org/biomodels.db/MODEL1310110053#_f48fbd7c_1635_4125_ae73_7034fc14f998
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:56894
name: AGPAT3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_c9e7c666_0b19_4e0a_8837_1460f5d12edc
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:80864
is: Q99944
boundary condition: true
constant: false
is: SBO:0000252
name: EGFL8
has only substance units: false

metaM ppa c
boundary condition: false
has only substance units: false
is: CHEBI:17272
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
name: propionate
type: Species
is: HMDB00237
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_2deb33b4_7ede_495a_8c3e_ea3c28a992af
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
name: HMGCS2
boundary condition: true
is encoded by: hsa:3158
initial amount: NaN
is: P54868

metaR PCHOLPr hs
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.4
product: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
name: choline phosphatase
modifier: MODEL1310110053#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110053#
reversible: false

metaR r1586
is: SBO:0000185
reversible: true
reactant: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110053#
type: Reaction

metaR RE1517M
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.13
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
name: RE1517
modifier: MODEL1310110053#
product: MODEL1310110053#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110053#_422fe761_f7a6_443e_9ecd_df37aef9aa67
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
name: HADH
is: Q16836
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3033

http://identifiers.org/biomodels.db/MODEL1310110053#_7e135508_0720_4d11_99a4_fae0719689c2
is encoded by: hsa:9061
name: PAPSS1
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is: O43252
has only substance units: false

metaM 3hbcoa m
initial concentration: 1.0
boundary condition: false
is: CHEBI:57316
is: SBO:0000247
has only substance units: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
name: (S)-3-hydroxybutanoyl-CoA(4-)
is: HMDB01166
type: Species
constant: false
initial amount: NaN

metaM arachcrn m
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
is: HMDB06460
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
name: arachidyl carnitine
type: Species
is: SBO:0000247
initial amount: NaN

metaM crn x
initial concentration: 1.0
is: C00318
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00062
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
name: L-Carnitine
is: SBO:0000247
type: Species
is: CHEBI:16347
has only substance units: false

metaM dcyt c
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial concentration: 1.0
boundary condition: false
name: Deoxycytidine
type: Species
is: CHEBI:15698
has only substance units: false
is: HMDB00014
constant: false
is: SBO:0000247
initial amount: NaN
is: C00881

metaM 7dhchsterol c
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
initial concentration: 1.0
is: HMDB00032
boundary condition: false
type: Species
is: CHEBI:17759
constant: false
is: SBO:0000247
has only substance units: false
name: cholesta-5,7-dien-3beta-ol
initial amount: NaN

metaR 4HPRO LTte
kinetic law: MODEL1310110053#
is: SBO:0000185
product: MODEL1310110053#
reactant: MODEL1310110053#
name: Transport of trans-4-hydroxy-L-proline
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
reversible: true
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_3965b2f7_9314_4b8b_85f0_62f1db8f8e6e
is: Q92819
name: HAS2
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:3037
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaM glu5sa m
initial amount: NaN
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
is: SBO:0000247
is: HMDB02104
type: Species
boundary condition: false
is: CHEBI:17232
initial concentration: 1.0
has only substance units: false
is: C01165
name: L-Glutamate 5-semialdehyde
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_7f674d0f_b460_4e64_9d5c_47d6ea340b8a
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:8140
name: SLC7A5
is: Q8IV97

http://identifiers.org/biomodels.db/MODEL1310110053#_2125d328_b257_48a9_995e_c76c6e11e3b3
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P35219
name: CA8
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:767
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_ca52bb1b_7983_4d99_8913_ba5d24fbf670
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: GPD1
type: Species
initial concentration: NaN
is encoded by: hsa:2819
boundary condition: true
is: F8W1L5

metaR r2384
is: SBO:0000185
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#

metaR SO4HCOtex
reversible: false
is: SBO:0000185
name: sulfate transport via bicarbonate countertransport
kinetic law: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (115111.1) or (115019.2) or (1836.1) or (115111.2) or (116369.2) or (284129.1) or (10861.2) or (116369.1) or (10861.1) or (10861.3) or (115019.1) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reactant: MODEL1310110053#
is described by: ECO:0000304
modifier: MODEL1310110053#
fast: false
product: MODEL1310110053#

metaM dchac e
boundary condition: false
is: SBO:0000247
name: deoxycholic acid
has only substance units: false
type: Species
notes: FORMULA: C24H39O4 CHARGE: -1
constant: false
initial amount: NaN
is: HMDB00626
initial concentration: 1.0

metaM Rtotal e
notes: FORMULA: CO2FULLR CHARGE: -1
constant: false
name: R total
boundary condition: false
is: HMDB00244
type: Species
is: C00255
is: CHEBI:3554
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_4ccee28e_4ec7_4ccb_8526_ebec46747666
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is: Q14117
is encoded by: hsa:1807
initial amount: NaN
initial concentration: NaN
name: DPYS
boundary condition: true

metaM HC02206 e
has only substance units: false
initial concentration: 1.0
name: prostaglandin C1(1-)
is: CHEBI:57399
boundary condition: false
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_564b8f25_c2f5_432c_bf4c_06181d89184b
constant: false
initial concentration: NaN
name: SLC5A5
has only substance units: false
is: Q92911
is: SBO:0000252
is encoded by: hsa:6528
boundary condition: true
type: Species
initial amount: NaN

metaM h2o2 c
has only substance units: false
boundary condition: false
is: C00027
initial amount: NaN
name: Hydrogen peroxide
constant: false
type: Species
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial concentration: 1.0
is: SBO:0000247
is: HMDB03125

http://identifiers.org/biomodels.db/MODEL1310110053#_b87d3a08_bbf1_44b0_8912_43baccf29f17
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
name: NT5C3
is encoded by: hsa:51251
boundary condition: true
is: Q9H0P0
is: SBO:0000252

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_989dfa52_46c1_41c3_9c24_690aeee6b404
has only substance units: false
is: Q5MY95
constant: false
is: SBO:0000252
name: ENTPD8
boundary condition: true
is encoded by: hsa:377841
initial amount: NaN
initial concentration: NaN
type: Species

metaM tdchola e
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
name: taurochenodeoxycholate
is: CHEBI:9407
is: HMDB00951

metaR r1876
kinetic law: MODEL1310110053#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110053#
is: SBO:0000185
modifier: MODEL1310110053#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110053#
fast: false

metaM triodthy c
is: HMDB00265
is: SBO:0000247
name: 3,3',5-triiodo-L-thyronine
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:18258
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
constant: false

metaR r1940
name: Y+LAT2 Utilized transport
reversible: false
reactant: MODEL1310110053#
product: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaM arachdcoa r
is: CHEBI:57368
is: SBO:0000247
is: HMDB06523
constant: false
type: Species
name: arachidonoyl-CoA(4-)
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249

metaR LNLNCGt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
is: SBO:0000185
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_a539f38c_ba20_43be_a183_aaf289ccd53a
constant: false
is: Q9Y303
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:51005
initial concentration: NaN
is: SBO:0000252
name: AMDHD2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_e543e4d3_1432_49dc_a851_5016f1030fb6
name: GALK2
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2585
constant: false
is: Q01415
is: SBO:0000252

metaR GLCt1r
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
product: MODEL1310110053#
is described by: ECO:0000269
name: glucose transport (uniport)
fast: false

metaM 3php c
initial amount: NaN
name: 3-phosphonatooxypyruvate(3-)
has only substance units: false
notes: FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232
constant: false
is: CHEBI:18110
is: SBO:0000247
is: HMDB01024
initial concentration: 1.0
type: Species
boundary condition: false

metaM gln L c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
constant: false
name: L-glutamine
initial amount: NaN
is: HMDB00641
has only substance units: false
is: CHEBI:18050
is: SBO:0000247
type: Species

metaR DGSNt
is described by: ECO:0000000
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is: SBO:0000185
reversible: true
fast: false
name: deoyguanosine transport via diffusion
type: Reaction

metaR DGCHOLtx
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is described by: ECO:0000000
product: MODEL1310110053#
is: SBO:0000185

metaR ANDRSTRNtr
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110053#
is: SBO:0000185
name: androsterone intracellular transport
kinetic law: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110053#

metaM ppi x
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: CHEBI:33019
is: HMDB00250
is: C00013
initial amount: NaN
name: Diphosphate
type: Species
boundary condition: false

metaM hspg l
is: CHEBI:15994
initial amount: NaN
name: heparan sulfate proteoglycan
is: HMDB00899
constant: false
is: SBO:0000247
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false

metaR r0720
reactant: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
kinetic law: MODEL1310110053#
fast: false
reversible: false
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

metaM glyald c
name: D-Glyceraldehyde
initial amount: NaN
has only substance units: false
is: CHEBI:17378
boundary condition: false
is: C00577
initial concentration: 1.0
is: HMDB01051
type: Species
constant: false
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: SBO:0000247

metaR XYLt
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
reversible: true
is described by: ECO:0000269
fast: false
type: Reaction
name: D-xylose reversible transport
kinetic law: MODEL1310110053#
is: SBO:0000185
reactant: MODEL1310110053#
modifier: MODEL1310110053#

metaM tcynt e
type: Species
constant: false
is: CHEBI:18022
initial amount: NaN
name: thiocyanate
has only substance units: false
is: SBO:0000247
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
boundary condition: false
is: HMDB01453
initial concentration: 1.0

metaM ala D e
type: Species
initial amount: NaN
boundary condition: false
name: D-alanine
is: CHEBI:15570
initial concentration: 1.0
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: HMDB01310
has only substance units: false
is: SBO:0000247

metaR r2382
is: SBO:0000185
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_b92b0511_e9f1_4adb_9a23_37b91b86312c
is: Q99714
boundary condition: true
type: Species
constant: false
is encoded by: hsa:3028
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: HSD17B10

metaR r1257
is: SBO:0000176
fast: false
product: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: EC:6.2.1.3
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110053#

metaM 3hibutcoa m
is: CHEBI:28259
is: SBO:0000247
type: Species
name: (S)-3-Hydroxyisobutyryl-CoA
is: HMDB01052
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_8ba39296_e473_4d35_a7e3_3fcd9f2dd947
has only substance units: false
name: PPAP2C
boundary condition: true
initial amount: NaN
is: E9PAY8
initial concentration: NaN
constant: false
is encoded by: hsa:8612
is: SBO:0000252
type: Species

metaM atp r
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: ATP(4-)
is: CHEBI:57299
is: SBO:0000247
initial amount: NaN
is: C00002
is: HMDB00538

http://identifiers.org/biomodels.db/MODEL1310110053#_e215758d_4db1_40e1_a482_5a0169718f07
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q9C0J1
constant: false
is encoded by: hsa:79369
has only substance units: false
name: B3GNT4
type: Species
boundary condition: true

metaM cmp g
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
name: CMP(2-)
is: SBO:0000247
is: CHEBI:60377
is: HMDB00095
initial concentration: 1.0
has only substance units: false
constant: false

metaM Rtotal c
is: SBO:0000247
is: CHEBI:16189
name: R total
boundary condition: false
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB01448
initial amount: NaN
notes: FORMULA: CO2FULLR CHARGE: -1

metaM HC02206 c
initial concentration: 1.0
name: prostaglandin C1(1-)
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:57399

http://identifiers.org/biomodels.db/MODEL1310110053#_97653f3a_4b91_46bc_b007_8f818080fa56
name: ALG8
boundary condition: true
type: Species
constant: false
is: Q9BVK2
is: SBO:0000252
is encoded by: hsa:79053
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM tdchola c
boundary condition: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB00951
name: taurochenodeoxycholate
is: CHEBI:9407
has only substance units: false

metaR r0830
modifier: MODEL1310110053#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.5.4.16
reversible: true
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110053#
type: Reaction
fast: false
kinetic law: MODEL1310110053#

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaR PYNP2r
fast: false
modifier: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.3
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
reversible: true
name: pyrimidine-nucleoside phosphorylase (uracil)
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_1946568c_f4b1_4034_8ebe_b4feb2a8c7e3
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:55350
name: VNN3
type: Species
has only substance units: false

metaM fru e
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: C00095
is: HMDB00660
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
name: D-Fructose
is: CHEBI:15824

http://identifiers.org/biomodels.db/MODEL1310110053#_507f5779_7584_4194_a221_d3ff182c549a
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:2762
has only substance units: false
is: O60547
boundary condition: true
name: GMDS
initial concentration: NaN

metaR MM6B2g
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.2.1.113
reversible: false
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_9c0cb223_e9fe_490b_9843_a4139d819771
has only substance units: false
constant: false
name: NDUFS2
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4720
initial amount: NaN
is: B7Z792
type: Species

metaR FMNAT
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
reversible: false
fast: false
name: FMN adenylyltransferase
type: Reaction
is described by: ECO:0000134
product: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.2
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_bb07b06b_2b18_4612_9d30_9c73ae081017
is encoded by: hsa:622
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
name: BDH1
is: Q02338
is: SBO:0000252
type: Species

metaR PETOHMm hs
fast: false
is described by: ECO:0000254
is: SBO:0000176
reversible: false
product: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
name: phosphatidylethanolamine N-methyltransferase
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
is version of: http://identifiers.org/ec-code/2.1.1.17
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#

metaM gln L e
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
type: Species
has only substance units: false
constant: false
name: L-glutamine
is: CHEBI:18050
boundary condition: false
is: HMDB00641

http://identifiers.org/biomodels.db/MODEL1310110053#_90f014c9_bd69_4142_946d_d71206c165e7
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is: Q8N9L9
name: ACOT4
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:122970

http://identifiers.org/biomodels.db/MODEL1310110053#_70c00d40_bb8e_44d5_be75_430dec0495a1
boundary condition: true
is: Q9NX14
initial amount: NaN
is encoded by: hsa:54539
initial concentration: NaN
name: NDUFB11
constant: false
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_acfde32b_9e3b_4eb2_95c4_426428a7d450
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: INPP5E
is encoded by: hsa:56623
is: Q9NRR6
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_5f69dd68_26b0_4769_a984_595b86526d14
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
is: P23786
boundary condition: true
name: CPT2
has only substance units: false
type: Species
is encoded by: hsa:1376

http://identifiers.org/biomodels.db/MODEL1310110053#_840959f2_2be8_4cb3_84ef_9b200487a857
constant: false
is: SBO:0000252
is encoded by: hsa:154091
initial concentration: NaN
type: Species
is: Q8TD20
boundary condition: true
has only substance units: false
name: SLC2A12
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_2bce90d3_fd1e_4240_b7e9_2821a7228ac4
has part: O14521
initial amount: NaN
has part: P31040
initial concentration: NaN
is encoded by: hsa:6391
is: SBO:0000297
name: SDHA:SDHB:SDHC:SDHD
boundary condition: true
has part: Q99643
is encoded by: hsa:6389
has part: P21912
constant: false
type: Species
has only substance units: false
is encoded by: hsa:6390
is encoded by: hsa:6392

http://identifiers.org/biomodels.db/MODEL1310110053#_f9236a5e_a992_40a3_906e_1bb309be84bf
initial concentration: NaN
is: P35475
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:3425
constant: false
is: SBO:0000252
boundary condition: true
name: IDUA

metaR r1088
name: Active transport
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
product: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
is: SBO:0000185

metaM retinal cis 13 r
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: HMDB06220
has only substance units: false
name: 13-cis-retinal
initial concentration: 1.0
is: CHEBI:45487
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: SBO:0000247

metaM amet m
constant: false
is: C00019
type: Species
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: HMDB01185
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15414
name: S-Adenosyl-L-methionine
initial amount: NaN
has only substance units: false
boundary condition: false

metaM tcynt c
is: CHEBI:18022
name: thiocyanate
is: HMDB01453
constant: false
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
initial concentration: 1.0

metaR LPS4e
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.4
modifier: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (50487.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10713052 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
product: MODEL1310110053#
name: phospholipase
reactant: MODEL1310110053#
reversible: false
type: Reaction

metaR RE3347C
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
name: RE3347
kinetic law: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110053#
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_600c80c5_44c5_40d4_a2d6_02f61285a233
initial concentration: NaN
name: NDUFA4
has only substance units: false
is: O00483
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:4697

metaR GALtly
is described by: ECO:0000000
reactant: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#
name: galactose efflux from lysosome

metaR TYRt
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
name: L-tyrosine transport
is described by: ECO:0000269
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true
is: SBO:0000185
modifier: MODEL1310110053#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_74708a86_e45a_4d69_ae51_5696d4db1ff9
has only substance units: false
is encoded by: hsa:1962
boundary condition: true
type: Species
constant: false
name: EHHADH
initial concentration: NaN
is: Q9NY65
initial amount: NaN
is: SBO:0000252

metaR r2519
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110053#
reversible: true
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000185
fast: false
name: Utilized transport

metaR r0836
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.5.4.16
modifier: MODEL1310110053#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true

metaR r2388
modifier: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110053#
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
kinetic law: MODEL1310110053#
type: Reaction

metaM cmp e
initial amount: NaN
name: CMP(2-)
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species
has only substance units: false
is: HMDB00095
is: CHEBI:60377
boundary condition: false
constant: false

metaM co2 e
initial amount: NaN
is: HMDB01967
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
type: Species
has only substance units: false
name: CO2
is: CHEBI:16526
boundary condition: false
is: C00011
constant: false

metaM ksi pre11 g
initial amount: NaN
is: CHEBI:28067
is: SBO:0000247
type: Species
constant: false
name: keratan sulfate I biosynthesis, precursor 11
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C129H208N9O101S3X CHARGE: -4

metaR r1254
is: SBO:0000176
fast: false
product: MODEL1310110053#
reversible: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110053#
name: EC:6.2.1.3
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaR r2387
is: SBO:0000185
product: MODEL1310110053#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
kinetic law: MODEL1310110053#
is described by: ECO:0000000
reactant: MODEL1310110053#
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_cc46e3af_a676_4369_a24b_2056538e28a4
initial concentration: NaN
is encoded by: hsa:2678
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
name: GGT1
boundary condition: true

metaM fru c
is: CHEBI:15824
name: D-Fructose
is: SBO:0000247
is: HMDB00660
initial amount: NaN
has only substance units: false
is: C00095
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095

http://identifiers.org/biomodels.db/MODEL1310110053#_cb58ed5e_eb9c_4d13_9570_e96a2ec54ab1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
is: O43570
initial amount: NaN
name: CA12
is encoded by: hsa:771

metaM ksi pre12 g
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 12
boundary condition: false
is: CHEBI:58053
is: C00130
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00175
has only substance units: false
constant: false
notes: FORMULA: C135H218N9O106S3X CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110053#_e7b672ac_b15b_44d1_bfd9_5a6da58dad1d
has only substance units: false
is: Q9HCQ5
is: SBO:0000252
is encoded by: hsa:50614
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: GALNT9
type: Species

metaR CYTK7n
product: MODEL1310110053#
is: SBO:0000176
reversible: true
fast: false
type: Reaction
name: cytidylate kinase (CMP,UTP),nuclear
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110053#_3f5aeaa3_b432_4643_8c06_93a2d1cdcb82
is: SBO:0000252
name: SLC24A3
is encoded by: hsa:57419
boundary condition: true
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: Q9HC58

http://identifiers.org/biomodels.db/MODEL1310110053#_532c7734_4549_4595_bb6b_54da3cff005e
has only substance units: false
is: SBO:0000252
name: GGH
is: Q92820
initial amount: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:8836
initial concentration: NaN

metaR SERDGLYexR
is described by: ECO:0000304
name: D-Serine/Glycine reversible exchange
reactant: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110053#
is: SBO:0000185
product: MODEL1310110053#
modifier: MODEL1310110053#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_a264d3d6_d766_46d8_aa7b_beed7cf44e2c
initial amount: NaN
name: GLUL
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: P15104
is encoded by: hsa:2752

http://identifiers.org/biomodels.db/MODEL1310110053#_ba250a25_8e48_4a15_a13a_4da3334ecf61
name: ALDH1B1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:219
is: P30837
constant: false

metaR UGLT
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.7.12
reversible: true
type: Reaction
name: UDPglucose--hexose-1-phosphate uridylyltransferase
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD

metaR r2386
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: false
reactant: MODEL1310110053#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_cffa5bb6_655d_4adb_b276_e49dd8ec10bc
initial amount: NaN
type: Species
is: Q13057
is encoded by: hsa:80347
boundary condition: true
has only substance units: false
name: COASY
initial concentration: NaN
is: SBO:0000252
constant: false

metaR EX 34hpp
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaM maltpt e
is: SBO:0000247
is: C02052
type: Species
is: HMDB01296
name: maltopentaose
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/5141
initial amount: NaN
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
constant: false
has only substance units: false

metaM focytC m
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
name: Ferrocytochrome C
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
is: CHEBI:16928
is: SBO:0000247
has only substance units: false

metaM bildglcur c
is: SBO:0000247
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
boundary condition: false
is: HMDB03325
type: Species
name: bis(beta-glucosyluronate)bilirubin
has only substance units: false
initial amount: NaN
is: CHEBI:58471
initial concentration: 1.0
constant: false

metaM hs deg9 l
name: heparan sulfate, degradation product 9
has only substance units: false
is: CHEBI:27491
is: SBO:0000247
constant: false
is: HMDB06465
initial concentration: 1.0
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
type: Species
initial amount: NaN
boundary condition: false

metaR GCHOLAte
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110053#
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
name: bile acid intracellular transport
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_7c657a2c_3225_4bb7_937d_712e575ca31e
initial amount: NaN
is: O95498
initial concentration: NaN
constant: false
name: VNN2
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8875
type: Species

metaR URIt
name: uridine facilated transport in cytosol
reversible: true
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
product: MODEL1310110053#
fast: false
type: Reaction
reactant: MODEL1310110053#
is described by: ECO:0000269
is: SBO:0000185

metaM triodthy e
initial concentration: 1.0
constant: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
boundary condition: false
initial amount: NaN
name: 3,3',5-triiodo-L-thyronine
is: CHEBI:18258
is: SBO:0000247
is: HMDB00265
type: Species
has only substance units: false

metaR r1467
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110053#
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110053#
fast: false
name: Postulated transport reaction
kinetic law: MODEL1310110053#

metaR UPPN
name: b-ureidopropionase
product: MODEL1310110053#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.6
fast: false
kinetic law: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
modifier: MODEL1310110053#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced

http://identifiers.org/biomodels.db/MODEL1310110053#_ca0be82b_4cf6_4fc1_a871_7fa6dd0c1cfd
is encoded by: hsa:4724
is: O43181
has only substance units: false
type: Species
boundary condition: true
name: NDUFS4
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR NCAMUP
name: Nicotinamide acid uptake
fast: false
type: Reaction
reactant: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069599,PMID:1463467 NOTES:SAB mechanism copied from nac--not certain
is described by: ECO:0000000

metaM xylt e
type: Species
is: HMDB02917
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
constant: false
is: SBO:0000247
name: xylitol
initial amount: NaN
is: CHEBI:17151
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_d79edfac_849c_4266_b23e_4ff03a7898b7
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:292
has only substance units: false
initial amount: NaN
is: Q6NVC0
initial concentration: NaN
type: Species
name: SLC25A5

metaM cmp c
name: CMP
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:60377
constant: false
is: HMDB00095
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: C00055
has only substance units: false

metaM co2 c
is: HMDB01967
name: CO2
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: CO2 CHARGE: 0
constant: false
is: CHEBI:3313
has only substance units: false
is: C00011

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_6228f749_22f9_48db_81c4_bd154ea61611
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: SLC24A4
has only substance units: false
constant: false
type: Species
is encoded by: hsa:123041

metaR r0834
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.16
is described by: ECO:0000000
product: MODEL1310110053#
modifier: MODEL1310110053#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
type: Reaction
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110053#
reversible: true
is: SBO:0000185

metaM dttp e
initial concentration: 1.0
type: Species
name: dTTP(4-)
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: HMDB01342
initial amount: NaN
constant: false
is: CHEBI:37568
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR r2385
product: MODEL1310110053#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
kinetic law: MODEL1310110053#
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR DAGt
type: Reaction
reversible: true
is described by: ECO:0000269
fast: false
is: SBO:0000185
name: diacylglycerol transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110053#
product: MODEL1310110053#
kinetic law: MODEL1310110053#

metaM cyan e
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB02084
is: CHEBI:18407
is: SBO:0000247
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
initial amount: NaN
name: hydrogen cyanide

metaM HC00900 c
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:30860
is: SBO:0000247
type: Species
name: Methylmalonate
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_c73061a0_e097_48d4_8fe5_b8234ffa2cbe
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6514
type: Species
boundary condition: true
is: P11168
initial concentration: NaN
name: SLC2A2
constant: false

metaR DKMPPD
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:JLR- based on B. subtilis and K. pneumoniae reactions (not sure about the h2o and h)
name: 2,3-diketo-5-methylthio-1-phosphopentane degradation reaction
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110053#
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
reversible: false

metaM andrstndn r
has only substance units: false
initial amount: NaN
type: Species
name: androst-4-ene-3,17-dione
constant: false
is: HMDB00053
boundary condition: false
is: SBO:0000247
notes: FORMULA: C19H26O2 CHARGE: 0 INCHI: InChI=1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00280
is: CHEBI:16422
initial concentration: 1.0

metaR r2308
reversible: true
kinetic law: MODEL1310110053#
fast: false
type: Reaction
product: MODEL1310110053#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110053#
is described by: ECO:0000000

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaM spc hs c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
type: Species
name: sphingosylphosphorylcholine
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5311445
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_eef0fac5_b996_4e10_ae16_e8df6448b11c
is encoded by: hsa:1723
is: Q02127
type: Species
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
name: DHODH
initial concentration: NaN
initial amount: NaN

MODEL1310110053
reaction: metaR r1396
reaction: metaR SPHK21c
reaction: metaR CYTK7
reaction: metaR ACGAMtly
species: metaM paps c
species: metaM uacgam c
reaction: metaR r0999
species: metaM atp x
species: metaM 20ahchsterol m
reaction: metaR CHOLtn
reaction: metaR r2328
species: metaM orn m
species: metaM acn13acngalgbside hs e
reaction: metaR DOLPMT1 Uer
reaction: metaR ACACt2
species: metaM gtp m
species: metaM dgdp n
reaction: metaR EX hspg LPAREN e RPAREN
reaction: metaR AK2LGCHOLt
reaction: metaR CSND
species: metaM tsul m
species: metaM udpglcur r
species: metaM HC02187 c
reaction: metaR RE0383C
species: metaM HC02217 e
species: metaM ach e
species: metaM e4hglu m
reaction: metaR EX glyc S LPAREN e RPAREN
species: metaM rib D c
reaction: metaR 5MTHFt
species: metaM dtdp m
reaction: metaR ADPtx
reaction: metaR r0527
reaction: metaR r0797
species: metaM crm hs r
reaction: metaR r2080
reaction: metaR ACACt2m
species: metaM paf hs e
reaction: metaR G14T8g
reaction: metaR r2376
species: metaM itacon m
species: metaM 2mb2coa m
reaction: metaR r1587
notes: Thiele2013 - Kidney cells in glomeruli The model of kidney cells in glomeruli metabolism is derived from the community-driven global reconstruction of human metabolism (version 2.02, MODEL1109130000 ). This model is described in the article: A community-driven global reconstruction of human metabolism. Thiele I, et al . Nature Biotechnology Abstract: Multiple models of human metabolism have been reconstructed, but each represents only a subset of our knowledge. Here we describe Recon 2, a community-driven, consensus 'metabolic reconstruction', which is the most comprehensive representation of human metabolism that is applicable to computational modeling. Compared with its predecessors, the reconstruction has improved topological and functional features, including ~2x more reactions and ~1.7x more unique metabolites. Using Recon 2 we predicted changes in metabolite biomarkers for 49 inborn errors of metabolism with 77% accuracy when compared to experimental data. Mapping metabolomic data and drug information onto Recon 2 demonstrates its potential for integrating and analyzing diverse data types. Using protein expression data, we automatically generated a compendium of 65 cell type-specific models, providing a basis for manual curation or investigation of cell-specific metabolic properties. Recon 2 will facilitate many future biomedical studies and is freely available at http://humanmetabolism.org/. This model is hosted on BioModels Database and identified by: MODEL1310110053 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
reaction: metaR r2311
species: metaM CE2432 m
species: metaM Asn X Ser Thr r
species: metaM lnlccoa m
species: metaM ocdca e
reaction: metaR NTD4
reaction: metaR NODe
reaction: metaR r0590
reaction: metaR r1629
species: metaM saccrp L m
reaction: metaR r0062
species: metaM nadh m
species: metaM cmpacna n
reaction: metaR RE1233C
reaction: metaR r2082
species: metaM h m
species: metaM dgsn e
reaction: metaR r1598
species: metaM nadp c
species: metaM 5adtststerones e
species: metaM xylt e
reaction: metaR DOPAtu
species: metaM CE2433 m
species: metaM met L c
species: metaM HC01223 m
species: metaM oaa c
reaction: metaR STRDNCt
species: metaM retinal 11 cis c
species: metaM tcynt c
species: metaM clpndcoa c
reaction: metaR r0974
reaction: metaR r1594
species: metaM galgbside hs g
reaction: metaR TRPt
reaction: metaR P45027A1m
reaction: metaR RE1530C

metaR r0835
is described by: ECO:0000000
reactant: MODEL1310110053#
modifier: MODEL1310110053#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.16
product: MODEL1310110053#
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_84ed006c_2a97_40d5_84b8_4ec6f0e1bfd0
is: Q86WU2
initial amount: NaN
is encoded by: hsa:197257
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
name: LDHD
constant: false
initial concentration: NaN

metaM dhcholestanate c
initial concentration: 1.0
type: Species
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: HMDB00359
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: CHEBI:16577
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247

metaR MG1er
type: Reaction
is: SBO:0000176
reactant: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
reversible: false
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.2.1.106
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_34110f54_240c_4daf_ab70_ea02e94fdd16
is encoded by: hsa:6568
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: Q14916
type: Species
boundary condition: true
is: SBO:0000252
name: SLC17A1

metaM ppi r
is: C00013
constant: false
has only substance units: false
name: Diphosphate
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial amount: NaN
is: HMDB00250
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:33019
boundary condition: false

metaM atp x
is: C00002
is: CHEBI:57299
type: Species
has only substance units: false
is: HMDB00538
is: SBO:0000247
constant: false
initial amount: NaN
name: ATP(4-)
boundary condition: false
initial concentration: 1.0

metaM glyald m
is: HMDB01051
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:17378
type: Species
constant: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial amount: NaN
name: D-glyceraldehyde

metaR LNLCCPT1
type: Reaction
name: carnitine O-palmitoyltransferase
is: SBO:0000176
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
product: MODEL1310110053#
reactant: MODEL1310110053#
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110053#

metaR OCDCEAtr
fast: false
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110053#
name: fatty acid transport via diffusion
is: SBO:0000185
kinetic law: MODEL1310110053#

metaR S6T1g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
reversible: false

metaM xylt c
has only substance units: false
is: HMDB02917
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: SBO:0000247
name: xylitol
type: Species
boundary condition: false
constant: false
is: CHEBI:17151
initial concentration: 1.0

metaM prostgh2 c
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB01381
is: CHEBI:57405
is: SBO:0000247
has only substance units: false
name: prostaglandin H2(1-)
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
boundary condition: false

metaR UAGDP
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.23
is described by: ECO:0000269
fast: false
is: SBO:0000176
product: MODEL1310110053#
reversible: false
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
name: UDP-N-acetylglucosamine diphosphorylase
reactant: MODEL1310110053#
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#

metaM C02528 c
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: HMDB00518
name: chenodeoxycholate
is: CHEBI:36234
initial concentration: 1.0
constant: false
has only substance units: false

metaM ser D c
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: SBO:0000247
is: HMDB03406
boundary condition: false
initial concentration: 1.0
name: D-serine
is: CHEBI:16523
constant: false

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaR AG13T11g
reactant: MODEL1310110053#
modifier: MODEL1310110053#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110053#
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false

metaM gly e
is: C00037
has only substance units: false
is: CHEBI:3339
type: Species
name: Glycine
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00123
notes: FORMULA: C2H5NO2 CHARGE: 0
boundary condition: false
constant: false

metaM hs deg12 l
type: Species
name: heparan sulfate, degradation product 12
initial amount: NaN
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
is: CHEBI:17180
is: SBO:0000247
is: HMDB01352
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM bildglcur e
boundary condition: false
constant: false
is: HMDB03325
name: bis(beta-glucosyluronate)bilirubin
type: Species
is: CHEBI:58471
has only substance units: false
is: SBO:0000247
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
initial amount: NaN
initial concentration: 1.0

metaR BTNt4i
product: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
kinetic law: MODEL1310110053#
is described by: ECO:0000269
reversible: false
is: SBO:0000185
modifier: MODEL1310110053#
name: Biotin uptake (antiport)

metaR UGLCNACtg
product: MODEL1310110053#
type: Reaction
name: UDP-GlcNAc Golgi transport via CMP antiport
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110053#
modifier: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD

metaR r0728
is: SBO:0000176
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110053#
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_ea017508_5613_422c_9384_6f6ace96a9ff
is: O60762
constant: false
is encoded by: hsa:8813
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
name: DPM1

metaR r1947
product: MODEL1310110053#
fast: false
is: SBO:0000185
modifier: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
reversible: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR LNLCCPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110053#
reversible: false
name: carnitine transferase
is described by: ECO:0000000
modifier: MODEL1310110053#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
product: MODEL1310110053#
reactant: MODEL1310110053#

metaR RE1533M
modifier: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110053#
name: RE1533
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110053#_651f565b_aca0_4ba7_b91e_74cebcc34d88
is: SBO:0000252
name: GCNT3
type: Species
is encoded by: hsa:9245
boundary condition: true
has only substance units: false
initial concentration: NaN
is: O95395
initial amount: NaN
constant: false

metaR r1464
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
reversible: true
name: Active transport
type: Reaction
kinetic law: MODEL1310110053#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110053#_df05e726_f133_4d6a_8ad2_12d172eb0785
has only substance units: false
is encoded by: hsa:8875
name: VNN3:VNN2:VNN1
constant: false
type: Species
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:8876
has part: O95497
has part: A8K7W0
initial amount: NaN
is encoded by: hsa:55350
boundary condition: true

metaR HAtly
is described by: ECO:0000000
product: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: hyaluronan transport, extracellular to lysosome
is: SBO:0000185
kinetic law: MODEL1310110053#
reversible: false
fast: false
reactant: MODEL1310110053#

metaM 5mdru1p c
type: Species
is: CHEBI:58548
notes: FORMULA: C6H11O7PS CHARGE: -2
is: C04582
name: 5-Methylthio-5-deoxy-D-ribulose 1-phosphate
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB01299
boundary condition: false

metaM h2o2 m
is: HMDB03125
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: C00027
is: CHEBI:16240
name: Hydrogen peroxide
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_a9ea0844_1d99_4855_9f02_2a2437f22f28
initial concentration: NaN
name: FOLR1
initial amount: NaN
constant: false
is encoded by: hsa:2348
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM spc hs e
initial amount: NaN
boundary condition: false
type: Species
name: sphingosylphosphorylcholine
is: http://identifiers.org/pubchem.compound/5311445
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_8436145a_ca17_4853_a89a_71092988f3a6
name: MPST
boundary condition: true
constant: false
is: SBO:0000252
is: P25325
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:4357

metaR N4Tg
name: N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
reversible: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110053#

metaR BILIRUBtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110053#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110053#
reversible: true
type: Reaction
product: MODEL1310110053#
name: lipid, flip-flop intracellular transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110053#_9123c31e_6bd2_47e6_aa7a_d1b866077415
type: Species
is: Q9NP59
name: SLC40A1
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:30061
initial concentration: NaN

metaM prostgh2 e
boundary condition: false
type: Species
is: HMDB01381
is: CHEBI:57405
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
name: prostaglandin H2(1-)
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427

metaR PAFt
product: MODEL1310110053#
is: SBO:0000185
kinetic law: MODEL1310110053#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
type: Reaction
name: 1-alkyl 2-acteylglycerol 3-phosphocholine transport
reversible: true
reactant: MODEL1310110053#

metaM dhdascb c
boundary condition: false
initial amount: NaN
name: dehydroascorbide(1-)
type: Species
constant: false
is: CHEBI:58070
is: HMDB01264
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR RE3556C
name: RE3556
kinetic law: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_603d34c2_1dae_493c_9299_16a7a82cdaf1
initial amount: NaN
initial concentration: NaN
name: NDUFV1
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is: E5KNH5
type: Species
is encoded by: hsa:4723

metaR THRt4
modifier: MODEL1310110053#
name: L-threonine via sodium symport
kinetic law: MODEL1310110053#
reversible: false
reactant: MODEL1310110053#
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110053#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11254.1) or (81539.1) or (54407.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958 NOTES:JLR

metaR EX thym LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymine exchange
type: Reaction

metaM 4ppcys c
is: SBO:0000247
is: C04352
is: HMDB01117
is: CHEBI:59458
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
has only substance units: false

metaM gly c
has only substance units: false
constant: false
is: C00037
name: Glycine
type: Species
initial concentration: 1.0
is: CHEBI:3339
initial amount: NaN
notes: FORMULA: C2H5NO2 CHARGE: 0
is: SBO:0000247
boundary condition: false
is: HMDB00123

metaM ksii core2 pre1 g
name: keratan sulfate II biosynthesis, precursor 1
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C33H53N3O23X CHARGE: -1
is: SBO:0000247
is: CHEBI:28067
constant: false

metaM C02528 e
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00518
type: Species
is: CHEBI:36234
constant: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
initial concentration: 1.0
name: chenodeoxycholate

metaM nadp c
is: HMDB00217
type: Species
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: CHEBI:58349
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C00006
name: Nicotinamide adenine dinucleotide phosphate
boundary condition: false
has only substance units: false
initial amount: NaN

metaM ser D e
type: Species
name: D-serine
is: SBO:0000247
is: HMDB03406
has only substance units: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
boundary condition: false
constant: false
is: CHEBI:16523
initial concentration: 1.0
initial amount: NaN

metaR r0181
reversible: true
modifier: MODEL1310110053#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110053#
is: SBO:0000176
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
product: MODEL1310110053#
fast: false

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaM lnlc r
is: HMDB00673
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
boundary condition: false
name: linoleate
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:30245
initial concentration: 1.0

metaM ppi n
has only substance units: false
initial amount: NaN
type: Species
is: HMDB00250
initial concentration: 1.0
constant: false
boundary condition: false
name: diphosphate(3-)
is: CHEBI:33019
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247

metaR 4NPHSULT
reversible: false
name: 4-Nitrophenol Sulfotransferase
is described by: ECO:0000269
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
reactant: MODEL1310110053#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.8.2.1
kinetic law: MODEL1310110053#

metaR DOLDPP Uer
reversible: false
product: MODEL1310110053#
reactant: MODEL1310110053#
name: Dolichyl-diphosphate phosphohydrolase, human (uterus)
kinetic law: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.43
modifier: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD

metaR ACCOAtn
product: MODEL1310110053#
reversible: true
is: SBO:0000185
name: acetyl-CoA transport, nuclear
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110053#
is described by: ECO:0000000
reactant: MODEL1310110053#
fast: false

metaR r1949
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110053#
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: false
fast: false
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110053#_b354a2c3_9d47_42b8_af11_86536458de94
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:124935
name: SLC43A2
has only substance units: false
type: Species
is: Q8N370

metaR r0726
is version of: http://identifiers.org/ec-code/2.7.1.33
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110053#
is: SBO:0000176
reactant: MODEL1310110053#
fast: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110053#
product: MODEL1310110053#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reversible: true

metaM nadh c
initial amount: NaN
is: HMDB01487
boundary condition: false
constant: false
is: C00004
is: CHEBI:57945
type: Species
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3306
name: Nicotinamide adenine dinucleotide - reduced
has only substance units: false

metaM C05279 m
type: Species
is: SBO:0000247
has only substance units: false
name: trans,cis-Lauro-2,6-dienoyl-CoA
constant: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
initial concentration: 1.0
is: HMDB11123
initial amount: NaN
boundary condition: false
is: CHEBI:28387

http://identifiers.org/biomodels.db/MODEL1310110053#_aebc2e8d_e36c_4287_9fac_37ff47ef2f3f
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:AI684467
name: _AI684467_1_m
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_7c98027e_10f5_4a1a_aa3b_0997ad301fc7
name: _AU149534_1_m
boundary condition: true
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AU149534

http://identifiers.org/biomodels.db/MODEL1310110053#_93dc0d06_7ecc_40dd_902d_295c0955ad27
is encoded by: hsa:10797
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P13995
type: Species
name: MTHFD2

metaM 7dhchsterol r
name: cholesta-5,7-dien-3beta-ol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
type: Species
is: SBO:0000247
constant: false
is: HMDB00032
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:17759
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_763e25bb_e9f6_4959_aceb_3c9495b1a1a5
is encoded by: hsa:6448
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: P51688
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: SGSH

metaM arachdcoa x
is: SBO:0000247
is: HMDB06523
boundary condition: false
initial amount: NaN
is: CHEBI:57368
has only substance units: false
type: Species
constant: false
name: arachidonoyl-CoA(4-)
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
initial concentration: 1.0

metaM nm2masn g
constant: false
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: C05884
initial amount: NaN
boundary condition: false
notes: FORMULA: C42H70N3O30X CHARGE: 0
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_7505619c_c273_4697_b421_a5a6d12a4a57
name: CHKA
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1119
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_fe0b160c_db94_434b_9105_ccb7e2afc5e6
boundary condition: true
is encoded by: hsa:10400
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: PEMT
initial concentration: NaN
is: Q9UBM1

metaR DESAT22 2p
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110053#
is: SBO:0000176
reactant: MODEL1310110053#
type: Reaction
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
is described by: ECO:0000000
reversible: false
product: MODEL1310110053#

metaM HC00900 m
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:30860
constant: false
name: Methylmalonate
is: SBO:0000247
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
initial concentration: 1.0
has only substance units: false

metaR GALASE19ly
modifier: MODEL1310110053#
is described by: ECO:0000269
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
fast: false
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_ca770c5c_aec4_40f9_92df_0ff402fbe627
initial concentration: NaN
is encoded by: hsa:80308
constant: false
boundary condition: true
has only substance units: false
name: FLAD1
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_d4c832ee_0916_416d_827a_088732bc97de
has only substance units: false
is encoded by: hsa:79646
is: SBO:0000252
boundary condition: true
constant: false
is: Q9H999
initial concentration: NaN
name: PANK3
initial amount: NaN
type: Species

metaR r2380
product: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185

metaR AHCYStd
kinetic law: MODEL1310110053#
fast: false
name: diffusion of S-Adenosyl-L-homocysteine
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
type: Reaction
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110053#
is: SBO:0000185

metaM ppi m
initial amount: NaN
constant: false
initial concentration: 1.0
name: Diphosphate
boundary condition: false
is: SBO:0000247
has only substance units: false
is: C00013
is: CHEBI:33019
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
is: HMDB00250

metaR GALU
fast: false
reactant: MODEL1310110053#
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000134
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.9
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
name: UTP-glucose-1-phosphate uridylyltransferase
modifier: MODEL1310110053#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_e5b66ff8_ae70_4129_8803_df54ceeb6e53
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: RDH5
is encoded by: hsa:5959
is: Q92781

metaM L2aadp m
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
constant: false
is: HMDB00510
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58672
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
name: L-2-aminoadipate(1-)

http://identifiers.org/biomodels.db/MODEL1310110053#_47e74acd_2bf0_4729_96ea_4c75c25f0eb1
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: _F23536_1_m
is encoded by: hsa:F23536
constant: false
initial amount: NaN
type: Species

metaM ala D c
initial amount: NaN
is: HMDB01310
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
has only substance units: false
is: CHEBI:15570
initial concentration: 1.0
type: Species
name: D-alanine
constant: false
is: SBO:0000247
boundary condition: false

metaR r2202
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110053#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
modifier: MODEL1310110053#
fast: false

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaR 34HPPOR
kinetic law: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
modifier: MODEL1310110053#
reactant: MODEL1310110053#
reversible: false
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.27

http://identifiers.org/biomodels.db/MODEL1310110053#_13ff40cb_9583_4755_86bc_55d6a44fdd24
constant: false
initial amount: NaN
is: P56181
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
name: NDUFV3
is encoded by: hsa:4731
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_02ebb6f3_ab47_4d4d_a8c5_921630961078
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:AA629629
name: _AA629629_1_m
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_4650b104_313d_4620_90a7_dbd7476d64f0
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:AA788780
initial amount: NaN
constant: false
name: _AA788780_1_c

http://identifiers.org/biomodels.db/MODEL1310110053#_243e726e_4266_4a6e_a8a1_9af47892315f
is: SBO:0000252
type: Species
is encoded by: hsa:284273
has only substance units: false
initial concentration: NaN
constant: false
name: ZADH2
boundary condition: true
is: Q4G1C4
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_163d8876_1b08_4e1d_9898_57699779245f
is encoded by: hsa:2645
initial concentration: NaN
is: SBO:0000252
is: Q53Y25
name: GCK
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true

metaR r1943
is described by: ECO:0000000
reactant: MODEL1310110053#
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#

metaR TYRCBOX
modifier: MODEL1310110053#
name: L-Tyrosine carboxy-lyase
product: MODEL1310110053#
reversible: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.28
is described by: ECO:0000134

metaR HS2ly
name: heparan-N-sulfatase, lysosomal
is: SBO:0000176
reactant: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.10.1.1

metaM HC02121 c
boundary condition: false
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: S-(hydroxymethyl)glutathione(1-)
is: CHEBI:58758

metaR r0724
kinetic law: MODEL1310110053#
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction
modifier: MODEL1310110053#
product: MODEL1310110053#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.33
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16

metaR CYANtm
reversible: true
reactant: MODEL1310110053#
name: Cyanide transport via diffusion (mitochondrial)
product: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaM pan4p c
boundary condition: false
constant: false
has only substance units: false
is: C01134
initial concentration: 1.0
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: HMDB01416
name: Pantetheine 4'-phosphate
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:47942

http://identifiers.org/biomodels.db/MODEL1310110053#_cc3fd28b_23b0_475d_9a8e_1385d1352cd4
is encoded by: hsa:3098
initial concentration: NaN
initial amount: NaN
name: HK1
type: Species
is: SBO:0000252
is: B3KXY9
has only substance units: false
boundary condition: true
constant: false

metaR VALTA
kinetic law: MODEL1310110053#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
name: valine transaminase
product: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000176
reversible: true
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110053#_5c08e223_889c_4de8_a42e_2b42a5dee1f2
constant: false
is: P04183
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:7083
type: Species
is: SBO:0000252
name: TK1

metaM succ x
is: HMDB00254
type: Species
boundary condition: false
is: CHEBI:30031
name: Succinate
initial amount: NaN
constant: false
is: C00042
has only substance units: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_f308beea_992d_49de_b7ae_71292462f66d
initial amount: NaN
boundary condition: true
is encoded by: hsa:23563
name: CHST5
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q9GZS9

metaM andrstandn r
boundary condition: false
is: CHEBI:15994
type: Species
is: HMDB00899
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
name: 5alpha-androstane-3,17-dione
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
initial amount: NaN

metaR EX succ LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Succinate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_67f91402_c5ca_4731_870a_a849f8332e12
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:10965
boundary condition: true
name: ACOT2
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P49753

metaM mi4p D c
is: HMDB01313
initial concentration: 1.0
is: SBO:0000247
name: 1D-myo-inositol 4-phosphate(2-)
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3-,4+,5-,6-/m0/s1
constant: false
initial amount: NaN
is: CHEBI:58469

http://identifiers.org/biomodels.db/MODEL1310110053#_2e84d21a_5cfd_4622_ad87_3191e34499c0
initial amount: NaN
is encoded by: hsa:763
name: CA5A
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is: P35218
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_ac10a807_1800_48c7_835a_9c50503916f5
constant: false
has only substance units: false
is encoded by: hsa:10861
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: SLC26A1

metaM h2o2 e
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
has only substance units: false
is: CHEBI:16240
name: hydrogen peroxide
is: SBO:0000247
is: HMDB03125

metaR r2011
fast: false
reversible: false
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110053#
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_f6bf4fd4_54be_40cc_a475_77c4197d0fc9
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2530
initial amount: NaN
name: FUT8
constant: false
type: Species
is: SBO:0000252
is: G3V5N0

metaR r2200
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110053#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110053#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
modifier: MODEL1310110053#
reactant: MODEL1310110053#

metaR FAOXC204
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
product: MODEL1310110053#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110053#

metaR r2412
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
fast: false
reversible: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
product: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000000

metaR DNDPt36m
modifier: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
name: dGDP transport via dCDP antiport
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
fast: false

metaR 5MTHFt2le
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110053#
is described by: ECO:0000134
fast: false
name: 5-methyltetrahydrofolate transport via anion exchange
reversible: true
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_df512542_0a0f_4ea9_9e27_ff7d5486a462
type: Species
boundary condition: true
constant: false
name: ACAT2
is: SBO:0000252
initial concentration: NaN
is: Q9BWD1
initial amount: NaN
has only substance units: false
is encoded by: hsa:39

http://identifiers.org/biomodels.db/MODEL1310110053#_4333354f_0e41_4e6e_9a36_083c4d8244a5
is encoded by: hsa:4245
initial amount: NaN
name: MGAT1
type: Species
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: P26572
is: SBO:0000252

metaR FRDPtc
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
reversible: true
is described by: ECO:0000000
fast: false
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_84638912_f11c_4e97_a2a3_c7b2c2cce69a
initial concentration: NaN
constant: false
is encoded by: hsa:160851
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
name: DGKH
has only substance units: false
is: A8K0I1

metaM na1 r
is: HMDB00588
initial concentration: 1.0
constant: false
is: CHEBI:29101
boundary condition: false
name: sodium(1+)
is: SBO:0000247
has only substance units: false
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
type: Species
initial amount: NaN

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaM amet c
has only substance units: false
is: C00019
name: S-Adenosyl-L-methionine
initial amount: NaN
is: HMDB01185
is: CHEBI:15414
is: SBO:0000247
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
constant: false
boundary condition: false
initial concentration: 1.0
type: Species

metaM hspg e
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: heparan sulfate proteoglycan
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
is: HMDB00719
has only substance units: false
is: CHEBI:15699
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_3b080a3f_fe12_4b1f_a5db_79f711512e77
is encoded by: hsa:219
constant: false
boundary condition: true
is: P30837
name: ALDH1B1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false

metaR LINKDEG1ly
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
reactant: MODEL1310110053#
is described by: ECO:0000000
fast: false
reversible: false
name: degradation of proteoglycan linkage region, lysosomal
product: MODEL1310110053#
is: SBO:0000176
kinetic law: MODEL1310110053#

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR r0722
reversible: true
is: SBO:0000176
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/4.2.3.12
type: Reaction
fast: false
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110053#

metaM cyan m
initial concentration: 1.0
boundary condition: false
is: CHEBI:18407
initial amount: NaN
name: hydrogen cyanide
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB02084
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326

http://identifiers.org/biomodels.db/MODEL1310110053#_b66ce9fc_396b_40de_bf6c_24aaf6e2c0cf
is: SBO:0000252
name: COX4I1
has only substance units: false
initial concentration: NaN
is: P13073
initial amount: NaN
is encoded by: hsa:1327
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_f1108338_ba83_44ed_9d6a_51b7ea31e2e7
name: DDOST
is encoded by: hsa:1650
type: Species
constant: false
has only substance units: false
is: P39656
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR r1147
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110053#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_593641e5_286d_44e7_92b9_1b65ecff6891
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4712
boundary condition: true
name: NDUFB6
is: O95139
type: Species

metaR CMPACNAtg
type: Reaction
modifier: MODEL1310110053#
fast: false
product: MODEL1310110053#
name: CMP-Sia Golgi transport via CMP antiport
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#

metaR PAIL45P HStn
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110053#
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110053#
fast: false
product: MODEL1310110053#

metaR r2413
product: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
kinetic law: MODEL1310110053#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110053#_bbd39ee9_9662_4517_b62a_a374e3b06fcd
has only substance units: false
type: Species
name: AADAT
initial concentration: NaN
is: Q8N5Z0
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:51166

http://identifiers.org/biomodels.db/MODEL1310110053#_941b7c1e_a8b0_481a_83ba_9417ac69574e
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is: P49327
type: Species
name: FASN
is encoded by: hsa:2194
has only substance units: false

metaR r0186
reversible: false
kinetic law: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
modifier: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_b988fadd_146a_4dca_8221_b8cb57149d07
boundary condition: true
name: SULT1A1
is: SBO:0000252
is encoded by: hsa:6817
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: NaN

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

metaR r2201
kinetic law: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: MODEL1310110053#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110053#
modifier: MODEL1310110053#

metaR r1682
type: Reaction
fast: false
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110053#
reactant: MODEL1310110053#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110053#_ca089be8_5990_42db_a916_584283cac722
is encoded by: hsa:6539
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is: P48065
constant: false
name: SLC6A12
boundary condition: true
has only substance units: false

metaM aps c
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: 5'-adenylyl sulfate(2-)
is: CHEBI:58243
boundary condition: false
is: HMDB01003
constant: false
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224

metaR UAG2EMAi
fast: false
is version of: http://identifiers.org/ec-code/5.1.3.14
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
product: MODEL1310110053#
name: UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
reversible: false
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:
type: Reaction

metaR APAT2rm
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
is described by: ECO:0000212
fast: false
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.6.1.19
reactant: MODEL1310110053#
is: SBO:0000176
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
reversible: true
product: MODEL1310110053#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_4f682685_0cbb_437f_83af_f3ca6d2e16d1
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: DPM2
initial concentration: NaN
is: O94777
constant: false
is encoded by: hsa:8818
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_81dd89e0_a37e_4918_af99_bd695a15ac10
boundary condition: true
constant: false
initial concentration: NaN
name: PECR
type: Species
is encoded by: hsa:55825
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q9BY49

http://identifiers.org/biomodels.db/MODEL1310110053#_ee4e156f_2f79_4a47_9c46_b49d5fc2c573
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:53630
has only substance units: false
constant: false
is: Q9HAY6
initial amount: NaN
boundary condition: true
name: BCMO1

http://identifiers.org/biomodels.db/MODEL1310110053#_d96219f1_44ab_410a_aea5_50bfb3ac5e68
initial amount: NaN
is: P42126
constant: false
boundary condition: true
type: Species
name: ECI1
is encoded by: hsa:1632
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM abt c
type: Species
has only substance units: false
is: HMDB01851
name: L-arabinitol
initial amount: NaN
boundary condition: false
is: CHEBI:18403
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
constant: false
initial concentration: 1.0

metaM i e
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: HMDB12238
is: CHEBI:16382
boundary condition: false
name: iodide
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708

metaR F1Atg
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
fast: false
name: F1alpha transport (from golgi to lysosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110053#

metaR r2095
is: SBO:0000185
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#

metaM nadh x
is: CHEBI:57945
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB01487
type: Species
initial concentration: 1.0
is: C00004
is: http://identifiers.org/pubchem.compound/3306
has only substance units: false
initial amount: NaN
name: Nicotinamide adenine dinucleotide - reduced

http://identifiers.org/biomodels.db/MODEL1310110053#_5dc28efb_78af_493d_9a48_3a70fc2fb04f
type: Species
name: SUCLG2:SUCLG1
boundary condition: true
is: SBO:0000297
is encoded by: hsa:8801
has only substance units: false
is encoded by: hsa:8802
has part: Q96I99
initial amount: NaN
initial concentration: NaN
has part: P53597
constant: false

metaM thymd c
is: HMDB00273
constant: false
type: Species
is: C00214
has only substance units: false
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
name: Thymidine
boundary condition: false
is: CHEBI:17748
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR RE3017R
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9799565,PMID:9862787 NOTES:
reversible: true
kinetic law: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
is: SBO:0000176
reactant: MODEL1310110053#
name: RE3017
fast: false

metaR CMPACNAtn
is: SBO:0000185
name: CMP-Sia nuclear export
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false
type: Reaction
reactant: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_e26e38cd_5c7e_4e31_8821_5dd12025b2e0
is: P30837
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
name: ALDH1B1
is encoded by: hsa:219

http://identifiers.org/biomodels.db/MODEL1310110053#_ca592317_0080_485d_bd3a_6499b0450dde
is encoded by: hsa:160728
is: SBO:0000252
name: SLC5A8
boundary condition: true
constant: false
initial amount: NaN
is: Q8N695
initial concentration: NaN
has only substance units: false
type: Species

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_4dcef44b_25d7_4522_bd33_da84ef21aa1a
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:2806
constant: false
is: P00505
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: GOT2

metaR Htg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110053#
is: SBO:0000185
reactant: MODEL1310110053#
type: Reaction
reversible: true
product: MODEL1310110053#
is described by: ECO:0000000
name: proton diffusion (Golgi)
fast: false

metaR STRDNCt
reactant: MODEL1310110053#
fast: false
reversible: true
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110053#
name: fatty acid transport via diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_54f2d9c6_e2b3_4619_8962_8a6998012694
initial amount: NaN
name: GCSH
is: P23434
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:2653
initial concentration: NaN
is: SBO:0000252
type: Species

metaR r0408
is: SBO:0000176
reversible: true
modifier: MODEL1310110053#
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
type: Reaction
product: MODEL1310110053#
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.5
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
is described by: ECO:0000000

metaR r1578
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
is: SBO:0000185
reactant: MODEL1310110053#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true

metaR RE3346M
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110053#
is: SBO:0000176
product: MODEL1310110053#
kinetic law: MODEL1310110053#
name: RE3346
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (217.1) or (219.1) or (501.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:

metaR r2094
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
product: MODEL1310110053#
reversible: true
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_4240f2c6_5909_445b_9136_b77ab7e087c1
is: SBO:0000252
is encoded by: hsa:493
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: P23634
name: ATP2B4
boundary condition: true
type: Species

metaM gchola c
has only substance units: false
is: CHEBI:58235
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00138
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
name: glycocholate

metaM dnad c
name: Deamino-NAD+
is: HMDB01179
has only substance units: false
is: CHEBI:18304
initial concentration: 1.0
is: C00857
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
type: Species
initial amount: NaN

metaM ksi pre19 g
type: Species
is: CHEBI:58053
is: SBO:0000247
is: C00130
constant: false
name: keratan sulfate I biosynthesis, precursor 19
boundary condition: false
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
is: HMDB00175
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM leuktrA4 e
is: SBO:0000247
is: HMDB01337
initial amount: NaN
boundary condition: false
constant: false
name: leukotriene A4(1-)
is: CHEBI:57463
initial concentration: 1.0
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
has only substance units: false
type: Species

metaM udpg c
has only substance units: false
boundary condition: false
is: C00029
type: Species
initial amount: NaN
name: UDPglucose
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
initial concentration: 1.0
is: HMDB00286
is: CHEBI:58367
is: SBO:0000247
constant: false

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaR HSAT4ly
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
product: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
reversible: false
name: heparan-glucosaminide N-acetyltransferase, lysosomal

metaM ade e
type: Species
name: adenine
is: CHEBI:16708
is: SBO:0000247
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: HMDB00034
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_51f8a955_1de5_45cf_911e_e58551f122b2
is encoded by: hsa:115111
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: Q8TE54
is: SBO:0000252
name: SLC26A7

http://identifiers.org/biomodels.db/MODEL1310110053#_38066618_596b_4566_ad76_330d4b536726
initial amount: NaN
is: Q9NUQ2
is: SBO:0000252
name: AGPAT5
constant: false
boundary condition: true
is encoded by: hsa:55326
type: Species
initial concentration: NaN
has only substance units: false

metaM 3mob m
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:11851
name: 3-methyl-2-oxobutanoate
boundary condition: false
has only substance units: false
type: Species
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141

metaR r2097
modifier: MODEL1310110053#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
fast: false
is: SBO:0000185
product: MODEL1310110053#

metaR G6PDH1rer
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
is version of: http://identifiers.org/ec-code/1.1.1.47
is described by: ECO:0000269
product: MODEL1310110053#
is: SBO:0000176
type: Reaction
reversible: true
fast: false

metaR r1575
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_4ae05c7a_407d_465b_8cc6_57b749f05cd2
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3550
is: Q13123
boundary condition: true
name: IK
has only substance units: false

metaR r0407
is version of: http://identifiers.org/ec-code/1.4.3.5
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110053#
is: SBO:0000176
modifier: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
fast: false
type: Reaction

metaM ksi pre35 g
is: SBO:0000247
constant: false
name: keratan sulfate I biosynthesis, precursor 35
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28067
has only substance units: false
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
boundary condition: false
type: Species

metaR r2015
kinetic law: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110053#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110053#
reactant: MODEL1310110053#

metaR G14T8g
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
modifier: MODEL1310110053#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
product: MODEL1310110053#
is: SBO:0000176
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.90

metaM thymd e
constant: false
is: C00214
type: Species
has only substance units: false
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
is: SBO:0000247
is: CHEBI:17748
initial amount: NaN
name: Thymidine
boundary condition: false
initial concentration: 1.0
is: HMDB00273

http://identifiers.org/biomodels.db/MODEL1310110053#_715b8bbc_0a26_4a91_95d3_462148f82534
is: SBO:0000252
is encoded by: hsa:LOC727762
constant: false
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
name: _LOC727762_1_m
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_e284035e_ddef_4238_967f_fdd74e57064f
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is: P54819
is encoded by: hsa:204
name: AK2
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_fafd16cf_2554_4bf9_85cd_2e3a4bbc7477
has part: B4E3E9
name: DLD:DLST:OGDH:PDHX
has only substance units: false
boundary condition: true
is: SBO:0000297
type: Species
initial concentration: NaN
is encoded by: hsa:4967
constant: false
initial amount: NaN

metaR KYNAKGAT
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
is: SBO:0000176
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.7
reversible: false
fast: false
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.6.1.64
type: Reaction
modifier: MODEL1310110053#
name: L-Kynurenine:2-oxoglutarate aminotransferase

http://identifiers.org/biomodels.db/MODEL1310110053#_7bac3184_4658_4cd3_baf8_bf911421a12d
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is: P19961
is: SBO:0000252
initial concentration: NaN
constant: false
name: AMY2B
is encoded by: hsa:280

metaR r2096
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
is: SBO:0000185
modifier: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
reversible: true
is described by: ECO:0000000

metaR r1576
product: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_d6d6fb8d_6391_4942_9d9c_5be36b4206c8
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: CPT1A
type: Species
is: Q8WZ48
constant: false
is encoded by: hsa:1374
has only substance units: false

metaM alpam m
name: S-aminomethyldihydrolipoamide
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
is: HMDB06239
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species

metaM pmtcrn x
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: SBO:0000247
name: L-palmitoylcarnitine
is: HMDB00222
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:17490

metaM hs deg19 l
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
is: HMDB01352
type: Species
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
name: heparan sulfate, degradation product 19
is: CHEBI:17180
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_72c026de_175a_4902_b7fd_875db3fdbb64
initial concentration: NaN
has only substance units: false
type: Species
name: SLC6A2
is: Q96KH8
is encoded by: hsa:6530
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_76a5f77e_fc5b_40d5_9175_caa0b31ff44c
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: O60760
name: HPGDS
initial concentration: NaN
boundary condition: true
is encoded by: hsa:27306

http://identifiers.org/biomodels.db/MODEL1310110053#_dd7d846e_3df6_411e_9976_ff5cf8951aa0
has only substance units: false
name: NT5C2
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is encoded by: hsa:22978
initial amount: NaN
is: P49902
initial concentration: NaN

metaM o2s m
type: Species
is: C00704
initial amount: NaN
is: SBO:0000247
name: Superoxide anion
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:18421
constant: false
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: HMDB02168

http://identifiers.org/biomodels.db/MODEL1310110053#_ad903487_5927_46d5_aebd_22cf1ee09be1
is encoded by: hsa:9060
has only substance units: false
initial amount: NaN
is: O95340
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: PAPSS2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_fc6fae74_0f03_47f3_a70c_8f320d4aafbb
name: ALG2
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:85365
type: Species

metaR r1603
reactant: MODEL1310110053#
is: SBO:0000185
product: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction

metaR r2099
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110053#
product: MODEL1310110053#

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaM dcholcoa r
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB06292
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:28701
name: chenodeoxycholoyl coenzyme a

http://identifiers.org/biomodels.db/MODEL1310110053#_b541c55f_d030_43b6_83e0_3c7d06733950
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:56606
initial amount: NaN
has only substance units: false
name: SLC2A9
is: Q9NRM0
initial concentration: NaN
boundary condition: true

metaM lnlccrn c
initial concentration: 1.0
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
name: Linoleyl carnitine
constant: false
is: HMDB06469
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM ksi g
type: Species
is: HMDB00189
initial amount: NaN
name: keratan sulfate I
initial concentration: 1.0
is: CHEBI:57614
boundary condition: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
constant: false
has only substance units: false
is: SBO:0000247

metaR ACHtn
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
name: Acetylcholin transport, nuclear trhough pores
type: Reaction
product: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaR r0033
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
fast: false
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
product: MODEL1310110053#
reactant: MODEL1310110053#
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:

metaM CE5121 m
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
constant: false
initial amount: NaN
has only substance units: false
name: trans-3-decenoyl-CoA
is: SBO:0000247
is: CHEBI:57449

metaR LYStm
reversible: true
fast: false
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
type: Reaction
reactant: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110053#
name: Lysine mitochondrial transport via ornithine carrier
kinetic law: MODEL1310110053#

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_817c675b_95b5_4a3a_af78_0a6a90b291b6
boundary condition: true
name: SLC3A2
initial concentration: NaN
is: P08195
has only substance units: false
is encoded by: hsa:6520
constant: false
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_8b9a6859_fed3_4953_817a_0f04ef4bfa42
constant: false
type: Species
initial concentration: NaN
name: DPM2
is encoded by: hsa:8818
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN

metaM ade c
is: CHEBI:16708
is: HMDB00034
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: Adenine
is: C00147
constant: false
initial concentration: 1.0

metaR ANDRSTRNte
reactant: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
type: Reaction
kinetic law: MODEL1310110053#
name: androsterone transport

metaM prostgi2 c
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB01335
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
boundary condition: false
is: CHEBI:57403
initial amount: NaN
name: prostaglandin I2(1-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_610fa190_acc1_483d_9c42_95ba5eb1a853
name: HADHB
is encoded by: hsa:3032
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
is: P55084
initial concentration: NaN

metaM atp c
constant: false
is: HMDB00538
has only substance units: false
boundary condition: false
is: C00002
name: ATP(4-)
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:30616

http://identifiers.org/biomodels.db/MODEL1310110053#_0ff03ade_3846_4414_9177_e253c5db37be
type: Species
is encoded by: hsa:7296
constant: false
name: TXNRD1
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR SQLSr
is version of: http://identifiers.org/ec-code/2.5.1.21
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
is: SBO:0000176
modifier: MODEL1310110053#
name: Squalene synthase
is described by: ECO:0000134
kinetic law: MODEL1310110053#
product: MODEL1310110053#

metaM 3mob e
name: 3-methyl-2-oxobutanoate
boundary condition: false
is: SBO:0000247
is: HMDB00019
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:11851
type: Species
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1

metaM ppi e
type: Species
is: SBO:0000247
constant: false
name: Diphosphate
initial amount: NaN
is: C00013
initial concentration: 1.0
has only substance units: false
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
boundary condition: false
is: CHEBI:33019

metaR r2098
is described by: ECO:0000000
kinetic law: MODEL1310110053#
is: SBO:0000185
reversible: true
reactant: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110053#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r1602
type: Reaction
product: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaR RE1521M
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110053#
product: MODEL1310110053#
reversible: true
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110053#
name: RE1521

metaM q10 m
is: SBO:0000247
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
initial concentration: 1.0
constant: false
type: Species
name: ubiquinone-10
boundary condition: false
is: CHEBI:46245
is: HMDB01072
initial amount: NaN
has only substance units: false

metaR AG13T9g
reversible: false
product: MODEL1310110053#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
kinetic law: MODEL1310110053#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110053#_e2d4fc64_ffcb_4ce6_a9ab_debde8e87953
is: SBO:0000252
constant: false
boundary condition: true
name: SLC16A7
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9194
type: Species
has only substance units: false
is: Q8NEM3

http://identifiers.org/biomodels.db/MODEL1310110053#_0c5f6bd5_21c9_4d62_a4a1_a4db4db476bd
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:U37519
has only substance units: false
name: _U37519_1_m
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_0dc07418_ca61_4844_b209_698eb40f0b34
is encoded by: hsa:7167
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
name: TPI1
boundary condition: true
is: Q53HE2
type: Species
is: SBO:0000252

metaR r2406
is: SBO:0000185
fast: false
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
product: MODEL1310110053#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110053#_980cd57a_1030_4232_aa15_c3d779780909
constant: false
is: A6NED0
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2954
initial amount: NaN
type: Species
has only substance units: false
name: GSTZ1

http://identifiers.org/biomodels.db/MODEL1310110053#_081a1b21_2021_4a1c_b757_864670b3fbeb
is encoded by: hsa:FLJ44968
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
name: _FLJ44968_1_m

http://identifiers.org/biomodels.db/MODEL1310110053#_9a993e23_0b0c_4fe1_8d27_0240ee348dec
boundary condition: true
name: _AI656480_1_m
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI656480
constant: false
is: SBO:0000252

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_2be9751a_c4cf_42cc_b0d1_1bd774b7a113
boundary condition: true
constant: false
name: LDHA:LDHB
is: SBO:0000297
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3945
has part: P07195

http://identifiers.org/biomodels.db/MODEL1310110053#_024a1ea6_01be_487b_a947_a7803da03ec0
initial concentration: NaN
has only substance units: false
name: ALG8
boundary condition: true
constant: false
is encoded by: hsa:79053
type: Species
initial amount: NaN
is: SBO:0000252

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaR r0517
product: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110053#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
fast: false

metaM succ m
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
type: Species
is: HMDB00254
name: Succinate
is: C00042
is: CHEBI:30031
initial amount: NaN

metaM core2 g
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C22H37N2O15X CHARGE: 0
name: Core 2
initial amount: NaN
is: CHEBI:15876

metaR r1579
product: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR 5MTAte
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110053#
type: Reaction
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000134
name: Transport of 5-S-methyl-5-thioadenosine
reactant: MODEL1310110053#

metaR STS1
reactant: MODEL1310110053#
is: SBO:0000176
is described by: ECO:0000269
name: Steryl-sulfatase
product: MODEL1310110053#
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.2
reversible: false
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ
type: Reaction

metaR AG13T1g
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
is: SBO:0000176
kinetic law: MODEL1310110053#
type: Reaction
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110053#

metaM g6p c
is: CHEBI:61548
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
name: D-Glucose 6-phosphate
initial concentration: 1.0
is: C00092
type: Species
is: HMDB01401
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false

metaM prostgi2 e
constant: false
is: HMDB01335
initial amount: NaN
is: CHEBI:57403
has only substance units: false
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
initial concentration: 1.0
name: prostaglandin I2(1-)
is: SBO:0000247
type: Species

metaR DHFtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is: SBO:0000185
product: MODEL1310110053#
type: Reaction
reversible: true
kinetic law: MODEL1310110053#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110053#
name: dihydrofolate reversible mitochondrial transport

metaM cala c
is: CHEBI:11892
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
name: N-carbamoyl-beta-alaninate
is: SBO:0000247
constant: false
is: HMDB00026
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642

metaM ppi c
type: Species
name: Diphosphate
is: CHEBI:0
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: C00013
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3
boundary condition: false

metaM 5fthf m
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
name: 5-formyltetrahydrofolate(2-)
is: CHEBI:57457
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
has only substance units: false
boundary condition: false
is: HMDB01562

metaM atp e
boundary condition: false
is: CHEBI:57299
has only substance units: false
is: C00002
is: SBO:0000247
initial amount: NaN
type: Species
name: ATP(4-)
initial concentration: 1.0
constant: false
is: HMDB00538

metaM HC01444 e
type: Species
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:15754
name: Galactosylglycerol
constant: false
initial concentration: 1.0

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaM ps hs m
has only substance units: false
boundary condition: false
type: Species
name: ps_hs[m]
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:18303
initial amount: NaN
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006

metaR r1600
reactant: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_c5f2a187_f762_4418_bb3c_dfaa1ae0351e
boundary condition: true
is: SBO:0000252
name: PAFAH2
is encoded by: hsa:5051
has only substance units: false
is: Q99487
initial amount: NaN
type: Species
constant: false
initial concentration: NaN

metaR r2520
kinetic law: MODEL1310110053#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
fast: false
reactant: MODEL1310110053#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110053#_221ee675_eb58_4618_b372_bab1e9786cdf
initial concentration: NaN
name: SLC27A1
initial amount: NaN
is: Q6PCB7
has only substance units: false
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:376497

metaM amp c
is: HMDB00045
notes: FORMULA: C10H12N5O7P CHARGE: -2
boundary condition: false
is: C00020
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: AMP
constant: false
type: Species
is: CHEBI:3322
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_4852b4f1_f73f_4668_8b88_5393b5f53536
name: _AA081045_1_e
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AA081045
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_bc1e4d6a_9ba8_4543_a181_a3a44b8e5489
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:171425
initial amount: NaN
name: CLYBL

http://identifiers.org/biomodels.db/MODEL1310110053#_26e6c104_eb0f_4678_aae7_94bac44109e6
is: Q9NWU1
has only substance units: false
name: OXSM
type: Species
initial concentration: NaN
is encoded by: hsa:54995
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true

metaR r1607
product: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110053#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_1fa23a28_28df_4990_8b14_fbb06d109f40
constant: false
is encoded by: hsa:57835
initial amount: NaN
is: SBO:0000252
name: SLC4A5
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_628f9b0a_a053_4f70_a32c_af8bbf99ccee
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:43
initial amount: NaN
name: ACHE

http://identifiers.org/biomodels.db/MODEL1310110053#_5c7de67c_883f_4c7a_9c95_8eb69f30e966
is: SBO:0000252
constant: false
initial concentration: NaN
is: P48735
boundary condition: true
type: Species
is encoded by: hsa:3418
initial amount: NaN
has only substance units: false
name: IDH2

metaM lnlc e
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
type: Species
name: linoleate
initial amount: NaN
is: HMDB00673
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:30245

metaM so4 c
initial concentration: 1.0
has only substance units: false
is: CHEBI:16189
is: SBO:0000247
constant: false
boundary condition: false
name: sulfate
is: HMDB01448
type: Species
initial amount: NaN
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059

http://identifiers.org/biomodels.db/MODEL1310110053#_125590ed_247c_4a80_95f4_f338ec55b9e1
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4698
name: NDUFA5
has only substance units: false
initial amount: NaN
is: Q16718
initial concentration: NaN
type: Species
constant: false

metaR O2tp
reactant: MODEL1310110053#
name: O2 transport, peroxisomal
reversible: true
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaM succ c
initial concentration: 1.0
initial amount: NaN
is: HMDB00254
type: Species
has only substance units: false
name: Succinate
is: C00042
is: CHEBI:30031
boundary condition: false
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: SBO:0000247

metaR ILEt5m
product: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is: SBO:0000185
name: Isoleucine mitochondrial transport
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110053#
type: Reaction

metaR MI1PP
is version of: http://identifiers.org/ec-code/3.1.3.25
is described by: ECO:0000269
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
modifier: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000176
kinetic law: MODEL1310110053#
name: myo-inositol 1-phosphatase

metaR r0512
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110053#
reversible: true
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
is: SBO:0000176
product: MODEL1310110053#
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:

metaM ps hs c
boundary condition: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: ps_hs[c]
is: CHEBI:18303

metaR r0400
modifier: MODEL1310110053#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.4
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
type: Reaction
product: MODEL1310110053#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_c792f12b_b5c6_4e7a_8dba_2c8f1310225c
name: GALNT10
is encoded by: hsa:55568
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR r1606
reactant: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110053#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_2bed9319_46eb_4a29_8816_c22f7fd259e6
initial concentration: NaN
type: Species
has only substance units: false
is: Q9UMR5
initial amount: NaN
is encoded by: hsa:9374
constant: false
is: SBO:0000252
boundary condition: true
name: PPT2

metaR EX sarcs LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sarcosine exchange
type: Reaction

metaR PItg
reactant: MODEL1310110053#
type: Reaction
name: phosphate transport, Golgi apparatus
reversible: false
product: MODEL1310110053#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110053#

metaM 4nph c
initial concentration: 1.0
has only substance units: false
is: CHEBI:57917
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
constant: false
is: HMDB01232
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 4-nitrophenolate
type: Species

metaR r1570
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110053#
type: Reaction
fast: false
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110053#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_65ee0b2d_e64c_4fb2_98b6_173306f18327
initial concentration: NaN
is: SBO:0000252
is: Q546Y9
name: AICDA
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:57379
boundary condition: true
has only substance units: false

metaM ksi pre16 g
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 16
has only substance units: false
is: HMDB00175
type: Species
is: CHEBI:58053
initial amount: NaN
is: C00130

metaR ALCD21 L
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.99.24
fast: false
name: alcohol dehydrogenase (L-1,2-propanediol)
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
product: MODEL1310110053#
is described by: ECO:0000304
kinetic law: MODEL1310110053#
is: SBO:0000176
modifier: MODEL1310110053#
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.1.1.1
reversible: false

metaM HC02202 e
has only substance units: false
constant: false
name: prostaglandin A1(1-)
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57398
boundary condition: false

metaR UDPG4E
modifier: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.1.3.2
type: Reaction
reactant: MODEL1310110053#
name: UDPglucose 4-epimerase
reversible: true
fast: false
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_c57b2f49_f455_4592_95fe_a8bae25c04ec
name: PLCB1
is: Q9NQ66
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:23236
has only substance units: false
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_0da3ae0e_391c_4286_810e_3a5d327b98df
has only substance units: false
name: NAGK
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:55577
is: Q9UJ70
boundary condition: true

metaM ocdca c
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00827
is: CHEBI:25629
initial concentration: 1.0
name: stearate
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
is: SBO:0000247
constant: false
has only substance units: false

metaR NADtru
reversible: false
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
type: Reaction
is: SBO:0000185
name: NAD transporter, endoplasmic reticulum
fast: false
is described by: ECO:0000000
product: MODEL1310110053#
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_91b09f7b_039d_493e_b30e_6d9eeab9decc
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110053#_785f2228_d26b_47d7_a449_7a03d2ca2abb
constant: false
is: SBO:0000252
name: TXNRD1
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:7296

metaR r1605
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110053#

metaR DHCR72r
is version of: http://identifiers.org/ec-code/1.3.1.21
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110053#
name: 7-dehydrocholesterol reductase
modifier: MODEL1310110053#
reversible: false
fast: false
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
reactant: MODEL1310110053#

metaR r2389
type: Reaction
is: SBO:0000185
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110053#
is described by: ECO:0000000
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
product: MODEL1310110053#

metaR r0377
type: Reaction
modifier: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000176
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110053#
product: MODEL1310110053#
reversible: false
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
fast: false

metaM 20ahchsterol m
initial concentration: 1.0
initial amount: NaN
is: CHEBI:1296
constant: false
is: HMDB06283
name: 20-hydroxycholesterol
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
type: Species

metaR r0839
modifier: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true
name: Postulated transport reaction
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.3.1.70
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_a7bc5913_35ad_4fb3_8582_4ef50bac8293
boundary condition: true
is encoded by: hsa:6561
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: Q9BZW2
is: SBO:0000252
name: SLC13A1

metaM cmp n
has only substance units: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
name: CMP(2-)
is: CHEBI:60377
is: HMDB00095
type: Species

metaM thymd m
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:17748
is: C00214
initial amount: NaN
is: HMDB00273
has only substance units: false
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
boundary condition: false
name: Thymidine

metaM lnlc c
boundary condition: false
name: linoleate
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00673
type: Species
has only substance units: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: CHEBI:30245

metaM gln L m
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: HMDB00641
is: CHEBI:18050
name: L-glutamine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_02634a76_1795_4b0d_b425_1d7186a640a9
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: GPI
is encoded by: hsa:2821
constant: false
is: P06744
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_f133c4b3_f254_45e1_85ec_8642eb107ff4
name: ADH1C
boundary condition: true
initial amount: NaN
is: P00326
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:126
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_66b1c0f8_90cf_407e_b217_767e77b02c1b
is encoded by: hsa:1811
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: SLC26A3
type: Species
initial amount: NaN
constant: false
is: P40879
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_071f3403_9c25_4e70_83c2_a90956953651
is encoded by: hsa:4716
type: Species
is: SBO:0000252
is: A8K761
name: NDUFB10
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false

metaR ILETAm
reactant: MODEL1310110053#
is: SBO:0000176
kinetic law: MODEL1310110053#
product: MODEL1310110053#
modifier: MODEL1310110053#
fast: false
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42
name: isoleucine transaminase, mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110053#_3561c33a_e6d3_489a_84a2_be88cfc48378
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AA664770
name: _AA664770_1_m
initial concentration: NaN
constant: false
type: Species

metaR r1604
is: SBO:0000185
type: Reaction
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
product: MODEL1310110053#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110053#_403c3df5_aaca_45ca_9bbd_39e41f36ae33
boundary condition: true
name: SLC5A12
type: Species
is: Q1EHB4
is encoded by: hsa:159963
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false

metaR r0838
is: SBO:0000185
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.4
modifier: MODEL1310110053#
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
reactant: MODEL1310110053#
name: Free diffusion
product: MODEL1310110053#
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_c7e34cfa_f823_4a4e_b18c_cc4b565d411a
is encoded by: hsa:3283
name: HSD3B1
type: Species
has only substance units: false
boundary condition: true
is: P14060
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false

metaR r0514
is described by: ECO:0000000
reversible: false
name: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
is: SBO:0000176
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:
product: MODEL1310110053#
fast: false
type: Reaction
modifier: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_ff046503_6d76_4e40_b30c_2b0f9cce88ed
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:AV717590
constant: false
name: _AV717590_1_m
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR r2521
fast: false
reactant: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110053#
name: Utilized transport
product: MODEL1310110053#

metaR r0627
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000176
reversible: true
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
product: MODEL1310110053#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_d464d330_faa5_41c5_bfd9_6ab6f0b1f72a
is: SBO:0000252
boundary condition: true
name: _AI539321_1_c
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:AI539321

metaM tcynt m
is: CHEBI:18022
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
initial amount: NaN
name: thiocyanate
has only substance units: false
is: HMDB01453
constant: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0

metaR PYRt2m
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
name: pyruvate mitochondrial transport via proton symport
fast: false
product: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_f3d8f72a_80af_4350_b97b_ce8b8fc9faaa
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:AL038231
name: _AL038231_1_c
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR ALADGLYexR
product: MODEL1310110053#
is described by: ECO:0000304
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
name: D-alanine/glycine reversible exchange
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
modifier: MODEL1310110053#
reversible: true

metaM nadh r
name: NADH(2-)
is: CHEBI:57945
is: SBO:0000247
type: Species
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
boundary condition: false
is: HMDB01487
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN

metaM creat c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:16919
is: HMDB00064
initial amount: NaN
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
name: creatine
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_e9888215_d413_426f_84cc_183fd7a558b3
initial amount: NaN
initial concentration: NaN
constant: false
is: P49189
is: SBO:0000252
name: ALDH9A1
type: Species
boundary condition: true
is encoded by: hsa:223
has only substance units: false

metaR r0483
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110053#
fast: false
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reversible: true

metaM HC02202 c
constant: false
initial amount: NaN
type: Species
boundary condition: false
name: prostaglandin A1(1-)
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
initial concentration: 1.0
is: CHEBI:57398

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaM ksi e
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: SBO:0000247
name: keratan sulfate I
is: HMDB00211
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
is: CHEBI:17268
initial amount: NaN

metaM 3mob c
has only substance units: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
name: 3-methyl-2-oxobutanoate
is: SBO:0000247
is: HMDB00019
is: CHEBI:11851
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false

metaM atp m
is: C00002
initial concentration: 1.0
is: SBO:0000247
is: HMDB00538
name: ATP(4-)
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:57299
type: Species
constant: false

metaR CYSt4
is described by: ECO:0000304
kinetic law: MODEL1310110053#
reversible: false
fast: false
modifier: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000185
name: L-cysteine reversible transport via sodium symport
reactant: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB

metaM 1glyc hs e
name: 1 acyl phosphoglycerol
has only substance units: false
is: CHEBI:57454
is: HMDB00972
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H13O7PFULLRCO2 CHARGE: -1
type: Species
constant: false
boundary condition: false

metaR THYMDt1
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
name: thymd transport
is: SBO:0000185
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:9693094 NOTES:TDV
product: MODEL1310110053#
type: Reaction
fast: false

metaM nadh m
initial amount: NaN
is: HMDB01487
is: C00004
is: SBO:0000247
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3306
name: Nicotinamide adenine dinucleotide - reduced
has only substance units: false
is: CHEBI:57945

http://identifiers.org/biomodels.db/MODEL1310110053#_873ef8de_7a83_4add_aa01_79017d166f45
boundary condition: true
name: HSD17B4
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: E9PB82
initial concentration: NaN
constant: false
is encoded by: hsa:3295
type: Species

metaR r1885
reactant: MODEL1310110053#
modifier: MODEL1310110053#
product: MODEL1310110053#
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110053#
type: Reaction
name: Y+LAT2 Utilized transport
is: SBO:0000185

metaR MG2er
kinetic law: MODEL1310110053#
type: Reaction
fast: false
is: SBO:0000176
reversible: false
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
is described by: ECO:0000000
product: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD

metaM ocdca e
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
is: C01530
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:25629
is: HMDB00827
has only substance units: false
initial concentration: 1.0
name: octadecanoate (n-C18:0)

metaR RE1691M
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
name: RE1691
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.8.1.1
type: Reaction
is: SBO:0000176
reversible: true
reactant: MODEL1310110053#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_e609fb32_e876_4c95_8167_da2484032cac
is: Q9BYC5
name: FUT8
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2530

metaR r0480
reversible: true
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
fast: false
reactant: MODEL1310110053#
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
product: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_0b5d887a_112d_45f8_b7f3_9e5b20fdd2ce
name: MAN1A1
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: P33908
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:4121

http://identifiers.org/biomodels.db/MODEL1310110053#_a714cb9e_2258_46f7_a5ff_ac41b016ba7d
is encoded by: hsa:60386
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q9HC21
name: SLC25A19
has only substance units: false
type: Species
initial amount: NaN

metaR PGDI
is version of: http://identifiers.org/ec-code/2.5.1.18
product: MODEL1310110053#
reversible: true
reactant: MODEL1310110053#
modifier: MODEL1310110053#
name: Prostaglandin-H2 D-isomerase [Precursor]
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
fast: false
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.3.99.2
type: Reaction

metaR 3HCO3 NAt
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000134
reversible: true
fast: false
type: Reaction
name: 3HCO3_NAt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).

metaM ca2 e
name: calcium(2+)
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: HMDB00464
is: CHEBI:29108

metaM gchola e
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00138
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C26H43NO6 CHARGE: 0
boundary condition: false
constant: false
name: glycocholate

metaR r1573
type: Reaction
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110053#
reactant: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185

metaR S23T2g
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
kinetic law: MODEL1310110053#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.4
modifier: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
reactant: MODEL1310110053#
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)

metaR NOt
is: SBO:0000185
type: Reaction
name: NO transport (diffusion)
product: MODEL1310110053#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#

metaR r0629
modifier: MODEL1310110053#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.22
fast: false
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.1.4.1
is: SBO:0000176
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
product: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
reversible: true

metaM co2 m
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:16526
name: CO2
is: SBO:0000247
is: C00011
constant: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: HMDB01967

metaM cmp m
initial amount: NaN
is: HMDB00095
initial concentration: 1.0
is: CHEBI:60377
boundary condition: false
type: Species
has only substance units: false
name: CMP(2-)
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_f52cf42a_f345_4bfd_8c64_979bc7c541d2
boundary condition: true
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10331
has only substance units: false
is: Q9Y2A9
is: SBO:0000252
name: B3GNT3

metaR r1574
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110053#
product: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110053#
fast: false
type: Reaction

metaM 4ppcys m
is: HMDB01117
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:59458
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_a7a78fdd_631e_4505_b8db_54df2297af25
constant: false
type: Species
name: _LOC728997_1_c
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:LOC728997

metaR LEUKTRB4t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110053#
is: SBO:0000185
name: leukotriene B4 transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_563ee8d5_9594_465b_8974_a15ccc233edb
initial amount: NaN
is: P04843
name: RPN1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6184
type: Species
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_1fba455c_b82b_4e8f_85a0_c41d7dce9ebd
is: SBO:0000252
boundary condition: true
is encoded by: hsa:89869
type: Species
is: Q86YW0
name: PLCZ1
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_b9e56508_1e04_45a3_9bd9_110f36415a93
name: _W74642_1_c
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:W74642

http://identifiers.org/biomodels.db/MODEL1310110053#_07de53ab_46ab_4653_b418_84d9ff1b5478
type: Species
is: P47989
boundary condition: true
is encoded by: hsa:7498
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: XDH
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_4754f0e2_c004_4e4f_a566_5e51f36e0a06
has only substance units: false
is: Q8NCL4
constant: false
initial concentration: NaN
name: GALNT6
type: Species
boundary condition: true
is encoded by: hsa:11226
is: SBO:0000252
initial amount: NaN

metaM creat e
is: HMDB00064
name: creatine
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:16919
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300

metaR GPAM hs
kinetic law: MODEL1310110053#
is: SBO:0000176
reactant: MODEL1310110053#
product: MODEL1310110053#
modifier: MODEL1310110053#
reversible: false
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.15
type: Reaction
notes: GENE_ASSOCIATION: (57678.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 2.3.1.15 Confidence Level: 4 AUTHORS: NOTES:NJ
name: glycerol-3-phosphate acyltransferase

metaM q10 e
initial concentration: 1.0
is: HMDB01072
has only substance units: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
type: Species
boundary condition: false
constant: false
is: CHEBI:46245
name: ubiquinone-10
is: SBO:0000247
initial amount: NaN

metaR RE2069C
type: Reaction
name: RE2069
is described by: ECO:0000000
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
fast: false
is: SBO:0000176
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_a5d84bfe_ce81_4442_9da2_e4ddf2415b4c
type: Species
is: SBO:0000252
constant: false
is: Q9Y217
initial amount: NaN
is encoded by: hsa:9107
name: MTMR6
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR GLYCtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: glycerol transport
product: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true
reactant: MODEL1310110053#
fast: false

metaR MAL Lte
reversible: true
name: Transport of L-malate
fast: false
kinetic law: MODEL1310110053#
is: SBO:0000185
reactant: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110053#_b215a209_0fa1_4436_b55b_ee858dcc4ac3
has only substance units: false
is encoded by: hsa:10317
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
name: B3GALT5
boundary condition: true
is: SBO:0000252

metaM lnlccrn m
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
is: HMDB06469
name: Linoleyl carnitine
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
boundary condition: false

metaM i c
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB12238
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
constant: false
name: iodide
is: CHEBI:16382
boundary condition: false

metaR DOLGLCP Uter
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is described by: ECO:0000000
reversible: false
is: SBO:0000185
product: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_95eeec9f_66a0_4081_9e63_0f0a811fd320
initial amount: NaN
name: _AI285872_1_c
constant: false
initial concentration: NaN
is encoded by: hsa:AI285872
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false

metaM dcholcoa x
is: SBO:0000247
boundary condition: false
is: CHEBI:28701
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
constant: false
initial amount: NaN
is: HMDB06292
initial concentration: 1.0
has only substance units: false
type: Species
name: chenodeoxycholoyl coenzyme a

metaR r2526
fast: false
kinetic law: MODEL1310110053#
is described by: ECO:0000000
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
reactant: MODEL1310110053#
product: MODEL1310110053#

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaR r1609
is: SBO:0000185
product: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110053#
is described by: ECO:0000000
reactant: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_5e0b11d0_b782_4027_8dc1_85a61a6ba4ae
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
name: _AI631997_1_m
is encoded by: hsa:AI631997
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_b068e846_43b0_4f55_9a04_3b5ed011e0d3
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:BF195998
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: _BF195998_1_x
type: Species

metaR S6T11g
type: Reaction
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
reversible: false
modifier: MODEL1310110053#
product: MODEL1310110053#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110053#
fast: false
is described by: ECO:0000000

metaM abt e
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: CHEBI:18403
name: L-arabinitol
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB01851

metaM succ e
boundary condition: false
is: SBO:0000247
is: HMDB00254
initial concentration: 1.0
is: CHEBI:30031
has only substance units: false
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
name: succinate(2-)
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_e1892063_b229_4865_bc58_bf330e38dd95
name: SLC5A11
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:115584
is: SBO:0000252
type: Species
is: Q8WWX8

http://identifiers.org/biomodels.db/MODEL1310110053#_933b7ac9_71ae_497c_b992_30646133dddf
is: Q96AT9
constant: false
boundary condition: true
name: RPE
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:6120

metaR PItn
reactant: MODEL1310110053#
fast: false
name: phosphate transport, nuclear
is described by: ECO:0000000
kinetic law: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110053#
is: SBO:0000185
type: Reaction

metaR r1571
kinetic law: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110053#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR EX thf LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange
type: Reaction

metaM ca2 c
has only substance units: false
is: CHEBI:29108
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
name: calcium(2+)
is: HMDB00464
initial concentration: 1.0

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaM hs deg23 l
is: CHEBI:21338
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
is: SBO:0000247
boundary condition: false
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
notes: FORMULA: C31H49NO29S CHARGE: -2
is: HMDB02704
initial amount: NaN

metaM atp n
initial concentration: 1.0
name: ATP(3-)
is: CHEBI:57299
type: Species
constant: false
has only substance units: false
is: HMDB00538
initial amount: NaN
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
boundary condition: false
is: SBO:0000247

metaM ps hs e
initial amount: NaN
is: CHEBI:18303
is: SBO:0000247
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
has only substance units: false
type: Species
name: phosphatidylserine
constant: false
boundary condition: false
initial concentration: 1.0

metaR r2525
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
kinetic law: MODEL1310110053#
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110053#

metaR 5MTHFt
type: Reaction
reversible: true
product: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#

metaR r1608
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction

metaM nadph c
is: CHEBI:57783
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: HMDB00221
is: SBO:0000247
is: C00005
constant: false
boundary condition: false
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate - reduced

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

metaR RE3626M
fast: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
name: RE3626
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110053#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110053#
reversible: false
reactant: MODEL1310110053#
is: SBO:0000176
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_06ff404a_814e_4522_9856_1e1e431accb3
is: SBO:0000252
is encoded by: hsa:51095
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q96Q11
constant: false
type: Species
name: TRNT1
boundary condition: true

metaR EX C02528 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chenodeoxycholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_402d3e2b_7340_446b_bdd5_772f5b5dd1d8
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:2348
name: FOLR1
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaM 4nph e
is: CHEBI:57917
name: 4-nitrophenolate
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
initial amount: NaN
is: HMDB01232
type: Species
is: SBO:0000247
boundary condition: false

metaR CLHCO3tex2
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is: SBO:0000185
modifier: MODEL1310110053#
reversible: false
name: chloride transport via bicarbonate countertransport (2:1)
type: Reaction
reactant: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#

metaM sql r
is: HMDB00256
is: CHEBI:15440
initial concentration: 1.0
type: Species
constant: false
name: squalene
boundary condition: false
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM HC02207 c
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
is: CHEBI:27555
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
name: prostaglandin-c2
initial concentration: 1.0
type: Species
initial amount: NaN

metaR THFtm
product: MODEL1310110053#
is: SBO:0000185
reversible: true
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
reactant: MODEL1310110053#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD

metaM ac c
boundary condition: false
name: acetate
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00042
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:30089
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_3a47d1ca_3a20_4a26_bf24_485698c133a1
is: SBO:0000252
is encoded by: hsa:AA576959
has only substance units: false
initial amount: NaN
constant: false
name: _AA576959_1_c
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_a5058b35_e430_4b2f_8a39_540808083f88
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: _AA526438_1_c
initial amount: NaN
boundary condition: true
is encoded by: hsa:AA526438
constant: false

metaR EX CE2250 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-oxodocosanoyl-CoA exchange
type: Reaction

metaM ksi pre4 g
is: C00130
type: Species
is: CHEBI:58053
boundary condition: false
notes: FORMULA: C101H165N7O72X CHARGE: -1
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
name: keratan sulfate I biosynthesis, precursor 4
is: HMDB00175
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_ea25fc11_b03a_49df_8666_5208a3defb59
boundary condition: true
constant: false
has part: Q07837
has part: P82251
type: Species
has only substance units: false
is encoded by: hsa:11136
initial concentration: NaN
initial amount: NaN
name: SLC7A9:SLC3A1
is: SBO:0000297
is encoded by: hsa:6519

metaR r1974
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110053#
is: SBO:0000185
reactant: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#
reversible: false
fast: false

metaM akg m
type: Species
name: 2-Oxoglutarate
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
is: C00026
initial concentration: 1.0
is: CHEBI:16810
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: HMDB00208
initial amount: NaN

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaR GGH 6THFe
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110053#
product: MODEL1310110053#
reversible: false
reactant: MODEL1310110053#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (6THF), extracellular

metaM chsterol e
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:16113
constant: false
is: HMDB00067
name: cholesterol
is: SBO:0000247
initial amount: NaN

metaR PRODt2r
reversible: true
name: D-proline reversible transport via proton symport
is: SBO:0000185
kinetic law: MODEL1310110053#
fast: false
type: Reaction
is described by: ECO:0000304
modifier: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form

http://identifiers.org/biomodels.db/MODEL1310110053#_db0ae0c2_94f2_445c_bb56_217e23660fd5
name: SUCLG1
initial concentration: NaN
is encoded by: hsa:8802
has only substance units: false
initial amount: NaN
is: P53597
type: Species
is: SBO:0000252
constant: false
boundary condition: true

metaR AHEXASE2ly
product: MODEL1310110053#
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaR CERT2rt
modifier: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
kinetic law: MODEL1310110053#
product: MODEL1310110053#
fast: false
reversible: true
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.11.1
name: ceramide transport protein
is described by: ECO:0000000
type: Reaction

metaR r0909
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
reactant: MODEL1310110053#
name: Transport reaction
is: SBO:0000185
product: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
reversible: true

metaM succoa m
initial concentration: 1.0
is: HMDB01022
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
has only substance units: false
constant: false
name: Succinyl-CoA
initial amount: NaN
boundary condition: false
is: CHEBI:57292
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_1ebead73_e465_4ab2_965e_213636afc5ec
name: SLC24A4
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: Q8NFF2
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:123041

metaM amp e
is: HMDB00045
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
name: AMP
type: Species
is: SBO:0000247
is: CHEBI:456215
is: C00020
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_74581a10_d1a4_4f26_a8f1_686715d7c136
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:728637
name: _728637_1_c

metaR COAtp
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
reactant: MODEL1310110053#
name: coenzyme A transport, peroxisomal
product: MODEL1310110053#
is: SBO:0000185
kinetic law: MODEL1310110053#

metaR r1973
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reactant: MODEL1310110053#
modifier: MODEL1310110053#
reversible: false
type: Reaction
product: MODEL1310110053#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM 2mp2coa m
is: SBO:0000247
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
constant: false
name: 2-Methylprop-2-enoyl-CoA
is: HMDB01011
has only substance units: false
is: CHEBI:27754
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_b3216f23_6c58_44c4_9d86_05ded674947b
constant: false
name: ACP5
has only substance units: false
initial amount: NaN
is encoded by: hsa:54
is: P13686
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true

metaM ksi pre25 g
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 25
is: CHEBI:58053
is: C00130
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_efd25215_ad27_45ea_95b0_a2457cdacc23
is encoded by: hsa:J03866
initial concentration: NaN
constant: false
is: SBO:0000252
name: _J03866_1_m
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN

metaM glyc S c
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C3H5O4 CHARGE: 0
is: HMDB06372
name: (S)-Glycerate
is: CHEBI:33871

metaM thcholstoic m
boundary condition: false
is: CHEBI:18402
has only substance units: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: HMDB03873

metaM 3mop m
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
type: Species
name: 3-methyl-2-oxopentanoate
constant: false
is: CHEBI:28654
is: HMDB00491
has only substance units: false

metaR SERtN1
is described by: ECO:0000269
name: Serine transport (Na, H coupled)
product: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true
fast: false
kinetic law: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaR DNDPt30m
kinetic law: MODEL1310110053#
fast: false
product: MODEL1310110053#
name: dCDP transport via ADP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
reversible: false
reactant: MODEL1310110053#

metaR S6T15g
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.8.2.21
is version of: http://identifiers.org/ec-code/2.8.2.17
type: Reaction
reactant: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
is described by: ECO:0000000
reversible: false
product: MODEL1310110053#

metaM glyb c
name: glycine betaine
type: Species
is: CHEBI:17750
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
initial amount: NaN
is: HMDB00043

metaR r0908
is described by: ECO:0000000
reversible: true
name: Postulated transport reaction
is: SBO:0000185
product: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
fast: false
reactant: MODEL1310110053#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_607e5f40_c1f5_4838_be3f_df307acadae0
initial amount: NaN
is: Q9H6Y6
boundary condition: true
type: Species
has only substance units: false
name: MYO5B
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:4645

metaM dump c
initial concentration: 1.0
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: HMDB01409
constant: false
boundary condition: false
is: CHEBI:246422
is: C00365
has only substance units: false
initial amount: NaN
name: dUMP
is: SBO:0000247
type: Species

metaM ac e
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
boundary condition: false
type: Species
is: HMDB00042
constant: false
name: acetate
initial concentration: 1.0
has only substance units: false
is: CHEBI:30089
initial amount: NaN
is: SBO:0000247

metaM HC00229 e
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:28189
initial concentration: 1.0
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
constant: false
initial amount: NaN
name: Isomaltose

metaR C204CPT2
type: Reaction
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.3.1.21
name: arachidonic acid transport into the mitochondria
kinetic law: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
reversible: false
reactant: MODEL1310110053#
fast: false
modifier: MODEL1310110053#

metaM arachd c
boundary condition: false
is: SBO:0000247
is: CHEBI:32395
initial concentration: 1.0
is: HMDB01043
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
name: arachidonate
type: Species

metaM acgam1p c
is: HMDB01367
name: N-Acetyl-D-glucosamine 1-phosphate
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
has only substance units: false
is: CHEBI:7125
initial concentration: 1.0
constant: false

metaM CE0693 m
is: CHEBI:28387
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
initial concentration: 1.0
type: Species
is: HMDB11123
constant: false
name: 3-oxolaur-6-cis-enoyl-CoA

metaR r2130
modifier: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#

metaM trdox m
initial concentration: 1.0
has only substance units: false
is: CHEBI:18191
constant: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
boundary condition: false
type: Species
name: Oxidized thioredoxin
initial amount: NaN
is: SBO:0000247

metaM dcdp m
type: Species
boundary condition: false
is: HMDB01245
initial amount: NaN
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
has only substance units: false
name: dCDP(3-)
initial concentration: 1.0
is: CHEBI:58593
constant: false
is: SBO:0000247

metaM chsterol c
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00067
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: SBO:0000247
is: CHEBI:16113
has only substance units: false
boundary condition: false
name: cholesterol

metaM dcdp n
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:58593
is: HMDB01245
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial amount: NaN
constant: false
name: dCDP(3-)

metaR M16NTg
is version of: http://identifiers.org/ec-code/2.4.1.143
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
product: MODEL1310110053#
modifier: MODEL1310110053#
is: SBO:0000176
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

metaR DURAD2
is version of: http://identifiers.org/ec-code/1.3.1.2
reactant: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000176
name: dihydrothymin dehydrogenase (NADP)

metaM 2mbcoa m
has only substance units: false
initial concentration: 1.0
is: HMDB01041
initial amount: NaN
is: CHEBI:57336
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
boundary condition: false
type: Species
is: SBO:0000247
name: 2-methylbutanoyl-CoA(4-)
constant: false

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaM m2mpdol U c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C1365H2240N20O320P20 CHARGE: -20
is: CHEBI:28049
constant: false
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
boundary condition: false
type: Species

metaM dgchol e
name: glycochenodeoxycholate
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:36252
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: HMDB00637
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false

metaM HC01115 c
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
name: NeuNGc
is: CHEBI:29025
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_36ef5e08_7f7d_4544_ac16_548046f771f6
type: Species
is: SBO:0000252
initial concentration: NaN
name: _LOC374569_1_e
has only substance units: false
initial amount: NaN
is encoded by: hsa:LOC374569
constant: false
boundary condition: true

metaR r2352
is described by: ECO:0000000
fast: false
product: MODEL1310110053#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110053#
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM 3mb2coa m
is: CHEBI:57344
is: HMDB01493
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: 3-methylbut-2-enoyl-CoA(4-)
constant: false
type: Species
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069

metaR MM7B2g
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.2.1.113
fast: false
reversible: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is: SBO:0000176
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110053#_79e8cade_70d5_4bb9_9e8b_8ab0190e704b
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
name: BCAT2
is: SBO:0000252
boundary condition: true
has only substance units: false
is: O15382
is encoded by: hsa:587

metaR 34DHPLACOX NADP
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (222.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
name: 3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase
product: MODEL1310110053#
is: SBO:0000176
reactant: MODEL1310110053#
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM leuktrE4 c
is: HMDB02200
is: CHEBI:57462
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
name: leukotriene E4(1-)
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR COAtr
product: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110053#
is described by: ECO:0000000
name: COA transporter, endoplasmic reticulum

metaM galgluside hs g
is: CHEBI:58223
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
is: C00015
name: galactosyl glucosyl ceramide
is: HMDB00295

metaM bilglcur r
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
has only substance units: false
name: mono(glucosyluronic acid)bilirubin(2-)
is: CHEBI:57767
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_1492a87b_f752_4210_8c19_3e49b744f71b
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
name: ATP2B2
is: SBO:0000252
is: Q4J699
type: Species
initial concentration: NaN
is encoded by: hsa:491

metaR DNDPt22m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110053#
reversible: false
type: Reaction
is: SBO:0000185
product: MODEL1310110053#
is described by: ECO:0000269
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
name: dTDP transport via dUDP antiport
fast: false

metaM Rtotalcoa c
is: CHEBI:16189
is: HMDB01448
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
name: R total Coenzyme A

metaR r2132
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110053#
reversible: true
kinetic law: MODEL1310110053#
product: MODEL1310110053#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_c2a63b82_35ed_4055_9808_3099bd029235
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is: P28330
name: ACADL
is encoded by: hsa:33
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_4c5a9107_8859_4691_8df4_09fc20e70b76
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:2348
initial concentration: NaN
boundary condition: true
name: FOLR1
is: SBO:0000252
constant: false

metaR COAtm
product: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
kinetic law: MODEL1310110053#
reversible: true
reactant: MODEL1310110053#
is: SBO:0000185
name: CoA transporter
modifier: MODEL1310110053#
is described by: ECO:0000269
type: Reaction

metaM dgchol c
boundary condition: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial amount: NaN
is: CHEBI:36252
initial concentration: 1.0
has only substance units: false
is: HMDB00637
is: SBO:0000247
type: Species
name: glycochenodeoxycholate
constant: false

metaR LEUTAm
is version of: http://identifiers.org/ec-code/2.6.1.42
reactant: MODEL1310110053#
product: MODEL1310110053#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110053#
name: leucine transaminase, mitochondrial
is described by: ECO:0000269
type: Reaction
fast: false
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD

metaR r1116
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
reversible: true
product: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
kinetic law: MODEL1310110053#

metaM nad m
is: HMDB00902
name: Nicotinamide adenine dinucleotide
is: http://identifiers.org/pubchem.compound/3305
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: C00003
initial concentration: 1.0
boundary condition: false
is: CHEBI:57540

http://identifiers.org/biomodels.db/MODEL1310110053#_cedec5b6_4000_4f8f_a95b_4602345d1060
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:115019
has only substance units: false
is: Q7LBE3
type: Species
name: SLC26A9
initial concentration: NaN

metaR r2420
product: MODEL1310110053#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true
kinetic law: MODEL1310110053#
is: SBO:0000185
reactant: MODEL1310110053#
type: Reaction
is described by: ECO:0000000

metaR MECOAS1m
type: Reaction
reactant: MODEL1310110053#
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
name: mesaconate--CoA ligase (GDP-forming)
is: SBO:0000176
reversible: true
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/6.2.1.4
fast: false
product: MODEL1310110053#

metaM 5adtststerones e
initial concentration: 1.0
name: 5alpha-Dihydrotestosterone sulfate
initial amount: NaN
is: HMDB06278
boundary condition: false
type: Species
has only substance units: false
constant: false
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
is: SBO:0000247

metaM sphings c
is: HMDB00252
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
constant: false
name: sphingosine(1+)
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:57756
type: Species

metaM dgtp e
constant: false
name: dGTP
is: CHEBI:16497
initial amount: NaN
is: HMDB01440
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286

metaR LDH L
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
is described by: ECO:0000000
name: L-lactate dehydrogenase
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.27
is: SBO:0000176
product: MODEL1310110053#
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
reversible: true
fast: false

metaM q10 c
is: CHEBI:46245
has only substance units: false
type: Species
boundary condition: false
name: ubiquinone-10
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB01072
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_metaR_EX_acn13acngalgbside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sialyl (1,3) sialyl (2,6) galactosylgloboside (homo sapiens) exchange
type: Reaction

metaR EX pectindchac LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectin-deoxycholic acid complex
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_6658a416_e7fb_41b3_83e7_2350d2492b25
initial concentration: NaN
type: Species
is: Q9UHI7
is: SBO:0000252
name: SLC23A1
is encoded by: hsa:9963
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_0433c5de_ec21_4df2_be00_beded05e645b
initial amount: NaN
initial concentration: NaN
constant: false
name: ALDH3A1
is: P30838
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:218

metaR r2131
type: Reaction
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000000
modifier: MODEL1310110053#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110053#

metaR GLYCt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110053#
type: Reaction
name: glycerol transport via channel
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
reversible: true

metaM 3odcoa m
constant: false
is: CHEBI:28528
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: 3-Oxodecanoyl-CoA
type: Species
boundary condition: false
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
initial amount: NaN
is: HMDB03939

metaR r0224
kinetic law: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110053#
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
reactant: MODEL1310110053#
reversible: false

metaR MAN6PI
is version of: http://identifiers.org/ec-code/5.3.1.8
product: MODEL1310110053#
name: mannose-6-phosphate isomerase
reactant: MODEL1310110053#
reversible: true
kinetic law: MODEL1310110053#
is: SBO:0000176
is described by: ECO:0000304
modifier: MODEL1310110053#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:

metaM bhb m
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:10983
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
type: Species
boundary condition: false
has only substance units: false
name: (R)-3-hydroxybutyrate
is: HMDB00011

http://identifiers.org/biomodels.db/MODEL1310110053#_3292367f_ffbd_4e5a_92d4_88ea9a46736d
name: ECHS1
is encoded by: hsa:1892
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: P30084
type: Species
constant: false
has only substance units: false
is: SBO:0000252

metaM dcholcoa c
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:28701
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
name: chenodeoxycholoyl coenzyme a
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB06292
is: SBO:0000247

metaR GK1
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.8
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
name: guanylate kinase (GMP:ATP)
is described by: ECO:0000269
fast: false

metaR IDOAASE2ly
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
name: alpha-L-iduronidase, lysosomal
reversible: false
reactant: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.76
type: Reaction
fast: false

metaM tmndnccoa c
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
has only substance units: false
is: HMDB06514
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
name: timnodonyl coenzyme A
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_901bebff_94fd_4ab7_a464_809aa976155e
is: Q8NFW8
constant: false
name: CMAS
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:55907
initial concentration: NaN

metaM trdrd m
has only substance units: false
name: Reduced thioredoxin
is: CHEBI:15967
constant: false
initial amount: NaN
type: Species
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_d7f6fea9_528b_4fb1_880b_4fe3b2450e47
type: Species
constant: false
is encoded by: hsa:AA278423
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: _AA278423_1_c

metaR BILDGLCURt
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
reactant: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
reversible: true
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
fast: false
modifier: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110053#

metaR PPAm
product: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
is version of: http://identifiers.org/ec-code/3.6.1.1
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
reversible: false
modifier: MODEL1310110053#
name: inorganic diphosphatase
type: Reaction
is described by: ECO:0000269

metaR BHBt
product: MODEL1310110053#
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110053#
is described by: ECO:0000000
reactant: MODEL1310110053#

metaM HC00319 m
is: CHEBI:30794
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
name: Malonate
constant: false
boundary condition: false
is: SBO:0000247

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaM 5adtststerones c
is: HMDB06278
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: 5alpha-Dihydrotestosterone sulfate
is: SBO:0000247
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
boundary condition: false

metaM retinol c
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: HMDB00305
name: retinol
is: CHEBI:50211
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM dgtp c
name: dGTP
is: CHEBI:16497
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB01440
has only substance units: false
type: Species
is: C00286
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: SBO:0000247

metaR C14STRr
is described by: ECO:0000134
name: C-14 sterol reductase
is version of: http://identifiers.org/ec-code/1.3.1.70
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
product: MODEL1310110053#
is: SBO:0000176
reversible: false
type: Reaction
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ

metaM pmtcrn c
is: SBO:0000247
initial amount: NaN
is: HMDB00222
has only substance units: false
constant: false
type: Species
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
name: L-palmitoylcarnitine
boundary condition: false
initial concentration: 1.0
is: CHEBI:17490

http://identifiers.org/biomodels.db/MODEL1310110053#_d4d08c40_9376_4dcc_a52a_e0c6da71baf0
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: P50226
is encoded by: hsa:6799
type: Species
is: SBO:0000252
constant: false
name: SULT1A2

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaM retinol e
is: CHEBI:50211
name: retinol
initial amount: NaN
is: HMDB00305
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
has only substance units: false
type: Species

metaR r2133
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110053#
product: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
is: SBO:0000185
reversible: true
reactant: MODEL1310110053#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR COAtn
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110053#
name: coenzyme A transport, nuclear
product: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_6a3e7965_7133_47d7_964e_e38e3c133174
initial amount: NaN
has only substance units: false
is encoded by: hsa:U37519
type: Species
boundary condition: true
name: _U37519_1_c
is: SBO:0000252
initial concentration: NaN
constant: false

metaR r1117
kinetic law: MODEL1310110053#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
reactant: MODEL1310110053#
name: Facilitated diffusion
is: SBO:0000185
fast: false
reversible: true

metaM cholate r
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C24H39O5 CHARGE: -1 INCHI: InChI=1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: CHEBI:29747
is: HMDB00619
type: Species
name: cholate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_94842ccf_386a_4dbd_ae0b_f2df57aa0fe2
is: P52824
initial amount: NaN
type: Species
name: DGKQ
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1609
constant: false

metaM taur e
is: CHEBI:3544
is: SBO:0000247
has only substance units: false
name: Taurine
boundary condition: false
is: C00245
constant: false
is: HMDB00251
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C2H7NO3S CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110053#_55e8adeb_51e4_41a8_8b58_f429276bac90
is encoded by: hsa:8706
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q8TDY1
name: B3GALNT1

metaM glyb e
is: CHEBI:17750
name: glycine betaine
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00043
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
type: Species

metaM hs deg6 l
boundary condition: false
has only substance units: false
is: HMDB01352
is: SBO:0000247
is: CHEBI:17180
initial amount: NaN
constant: false
name: heparan sulfate, degradation product 6
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_dedbef9b_b886_4538_a4b8_549b159ad603
type: Species
name: ALDH7A1
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is: E7EPT3
initial amount: NaN
is encoded by: hsa:501
initial concentration: NaN

metaR GAL3ST12
fast: false
reversible: false
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.8.2.11
is described by: ECO:0000269
product: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110053#
name: Galactosylceramide sulfotransferase

http://identifiers.org/biomodels.db/MODEL1310110053#_796792bb_6739_4565_964e_a266b2fc5b25
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:2530
name: FUT8
constant: false
boundary condition: true
initial amount: NaN
is: Q546E0

metaM trdox c
name: Oxidized thioredoxin
initial concentration: 1.0
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
is: CHEBI:18191
is: SBO:0000247
type: Species
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: C00343

metaR S6T7g
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
reversible: false
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110053#

metaR AG13T14g
type: Reaction
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
is: SBO:0000176
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110053#
fast: false

metaR FAOXC160
reactant: MODEL1310110053#
modifier: MODEL1310110053#
reversible: false
fast: false
kinetic law: MODEL1310110053#
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is described by: ECO:0000269
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction

metaM C02470 c
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5485
name: Xanthurenic acid
boundary condition: false
is: SBO:0000247
is: HMDB00881
constant: false
initial concentration: 1.0
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
type: Species
is: C02470

http://identifiers.org/biomodels.db/MODEL1310110053#_2b1ee437_e5c5_4f02_ae02_339badb2d683
is: SBO:0000252
name: _D87002_1_m
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:D87002
initial concentration: NaN
constant: false
initial amount: NaN

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_60e64075_43cf_42e8_acaf_237407ccb7cb
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI924226
type: Species
name: _AI924226_1_m
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN

metaM dcdp c
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial concentration: 1.0
constant: false
name: dCDP
type: Species
is: CHEBI:58593
is: C00705
boundary condition: false
has only substance units: false
is: HMDB01245
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_24180509_d53a_4666_9094_79018e061847
constant: false
name: CDA
is: SBO:0000252
initial amount: NaN
is: P32320
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:978

metaR r2023
reactant: MODEL1310110053#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
product: MODEL1310110053#

metaR UMPK3n
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is: SBO:0000176
product: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (UTP),nuclear
fast: false
reactant: MODEL1310110053#
modifier: MODEL1310110053#

metaM dopa c
is: CHEBI:59905
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
has only substance units: false
is: SBO:0000247
name: dopaminium(1+)
initial concentration: 1.0
is: HMDB00073
type: Species
constant: false
boundary condition: false
initial amount: NaN

metaM orot c
initial concentration: 1.0
constant: false
is: C00295
initial amount: NaN
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
has only substance units: false
is: SBO:0000247
is: HMDB00226
type: Species
name: Orotate
is: CHEBI:30839
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_2c051f0f_6ca0_49c8_a73e_637667072f2f
boundary condition: true
is encoded by: hsa:4701
is: SBO:0000252
name: NDUFA7
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q6FG42
type: Species

metaM arab L e
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0
is: CHEBI:30849
name: L-arabinose
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00646
type: Species
boundary condition: false
initial concentration: 1.0

metaM pmtcrn r
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
constant: false
has only substance units: false
type: Species
is: CHEBI:17490
boundary condition: false
is: HMDB00222
name: L-palmitoylcarnitine

metaM c226crn c
boundary condition: false
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
has only substance units: false
initial concentration: 1.0
constant: false
name: cervonyl carnitine
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/127055
is: HMDB06510
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_a27295cd_4da2_4080_b26c_d80679b270fb
type: Species
constant: false
boundary condition: true
is: A4D1D5
has only substance units: false
initial amount: NaN
name: ABCB4
initial concentration: NaN
is encoded by: hsa:5244
is: SBO:0000252

metaR ADSS
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
modifier: MODEL1310110053#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
fast: false
reversible: false
name: adenylosuccinate synthase
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/6.3.4.4
is described by: ECO:0000134

metaM glcur c
is: CHEBI:15748
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: HMDB00127
is: SBO:0000247
name: D-glucuronate
constant: false
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR PPAn
reactant: MODEL1310110053#
fast: false
type: Reaction
product: MODEL1310110053#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000176
reversible: false
name: inorganic diphosphatase, nuclear
kinetic law: MODEL1310110053#

metaM amp m
boundary condition: false
name: AMP(2-)
is: CHEBI:456215
is: HMDB00045
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
type: Species

metaR r2022
fast: false
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110053#
reactant: MODEL1310110053#
reversible: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110053#

metaM nad r
initial concentration: 1.0
has only substance units: false
is: CHEBI:57540
constant: false
type: Species
name: NAD(1-)
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB00902
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

metaR ADK1
reversible: true
fast: false
product: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: adenylate kinase

metaR ALAGLNexR
kinetic law: MODEL1310110053#
fast: false
reversible: true
is described by: ECO:0000304
is: SBO:0000185
name: L-alanine/glutamine reversible exchange
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110053#
type: Reaction
product: MODEL1310110053#

metaM aicar c
constant: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
has only substance units: false
is: HMDB01517
is: SBO:0000247
is: CHEBI:58475
boundary condition: false
type: Species
is: C04677
initial amount: NaN
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_19e29551_bd21_4464_a51a_ee8bf7f3accf
is encoded by: hsa:AA081045
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial concentration: NaN
name: _AA081045_1_c

metaM HC02217 c
initial amount: NaN
type: Species
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
is: SBO:0000247
initial concentration: 1.0
name: prostaglandin-g2
is: CHEBI:27647
has only substance units: false
constant: false
boundary condition: false

metaM ac m
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
name: acetate
type: Species
is: HMDB00042
initial amount: NaN
is: CHEBI:30089

metaM pectindchac e
has only substance units: false
is: SBO:0000247
name: pectin-deoxycholic acid complex
notes: FORMULA: C2559H3549O2539 CHARGE: -1
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB03402
type: Species

metaM arachd l
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
type: Species
is: HMDB01043
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:32395
name: arachidonate

http://identifiers.org/biomodels.db/MODEL1310110053#_018e3304_8ab4_4adc_a6dc_f4215b3f2bb1
constant: false
is: Q9UHI5
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:23428
initial amount: NaN
name: SLC7A8

http://identifiers.org/biomodels.db/MODEL1310110053#_7bca387a_3ada_4077_9792_338b519fb3ad
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: _AA614647_1_c
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:AA614647

http://identifiers.org/biomodels.db/MODEL1310110053#_22155e75_1230_44ae_939b_8164796defd7
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:R06874
boundary condition: true
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: _R06874_1_r

metaR MMEm
modifier: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
name: methylmalonyl-CoA epimerase/racemase
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/5.1.99.1

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaM dopa e
constant: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: HMDB00073
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
name: dopaminium(1+)
is: CHEBI:59905

http://identifiers.org/biomodels.db/MODEL1310110053#_66ec96e1_409f_4cd4_a903_fc80f013282b
name: MYO5B
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q9H6Y6
is encoded by: hsa:4645

metaR r0196
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110053#
product: MODEL1310110053#
modifier: MODEL1310110053#
reversible: true
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37

metaR PEt
product: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
reversible: true
name: phosphatidylethanolamine transport
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
reactant: MODEL1310110053#

metaR DDPGAm
type: Reaction
is described by: ECO:0000000
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
reversible: true
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_8f6ce25f_0d5e_4ab3_9595_caf5a220830a
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P48651
name: PTDSS1
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:9791

http://identifiers.org/biomodels.db/MODEL1310110053#_449c492d_eb77_4342_b82d_ec53816446a2
boundary condition: true
has only substance units: false
is: Q96P26
is encoded by: hsa:93034
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: NT5C1B
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_1a2e2f4a_0346_44b1_90ed_8961dc8cb1d9
name: GAL3ST1
initial concentration: NaN
is: Q99999
has only substance units: false
is encoded by: hsa:9514
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM e4p c
is: CHEBI:16897
name: D-Erythrose 4-phosphate
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB01321
is: SBO:0000247
is: C00279

metaR RE3520E
fast: false
kinetic law: MODEL1310110053#
is: SBO:0000176
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.11.1.9
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110053#
reactant: MODEL1310110053#
name: RE3520
reversible: true

metaM fe3 c
type: Species
initial concentration: 1.0
name: Fe3+
notes: FORMULA: Fe CHARGE: 3
boundary condition: false
constant: false
is: HMDB12943
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM mescoa m
name: Mesaconyl-CoA
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:27969
is: C06028
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
initial amount: NaN
type: Species

metaM udp n
initial amount: NaN
is: CHEBI:58223
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00295
initial concentration: 1.0
name: UDP(3-)
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015

http://identifiers.org/biomodels.db/MODEL1310110053#_1b2565f7_1342_4f73_9b57_c7126af8f3de
initial amount: NaN
has only substance units: false
boundary condition: true
is: P06865
constant: false
name: HEXA
is encoded by: hsa:3073
type: Species
is: SBO:0000252
initial concentration: NaN

metaM tmndnccoa m
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
type: Species
name: timnodonyl coenzyme A
initial amount: NaN
is: HMDB06514
initial concentration: 1.0
boundary condition: false

metaR ADK3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
product: MODEL1310110053#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110053#
reversible: true
name: adentylate kinase (GTP)
fast: false
modifier: MODEL1310110053#
reactant: MODEL1310110053#

metaR MTAP
fast: false
reversible: false
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
is: SBO:0000176
name: 5'-methylthioadenosine phosphorylase
product: MODEL1310110053#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.28
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (4507.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.4.2.28 Confidence Level: 4 AUTHORS: PMID:16000004,PMID:2543672,PMID:3091600 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_c3180fe0_a4ae_46a9_8667_508b1a56a05b
boundary condition: true
initial concentration: NaN
constant: false
name: NAE1
is: A8MU28
is encoded by: hsa:8883
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species

metaM dhea c
constant: false
initial amount: NaN
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
name: 3beta-hydroxyandrost-5-en-17-one
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28689
boundary condition: false
type: Species
has only substance units: false
is: HMDB00077

http://identifiers.org/biomodels.db/MODEL1310110053#_d09f5e5c_fdc5_4d62_b2d1_1749466ba873
is encoded by: hsa:AI824319
initial amount: NaN
name: _AI824319_1_r
constant: false
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252

metaM 1p3h5c m
is: HMDB01369
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:6151
has only substance units: false

metaR r0193
reactant: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
product: MODEL1310110053#
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110053#
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1

metaM bhb e
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: (R)-3-hydroxybutyrate
is: HMDB00011
is: CHEBI:10983

metaR FRDPtcr
type: Reaction
reversible: true
kinetic law: MODEL1310110053#
fast: false
is: SBO:0000185
reactant: MODEL1310110053#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
product: MODEL1310110053#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.

metaM aicar e
initial concentration: 1.0
is: CHEBI:58475
type: Species
is: HMDB01517
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: C04677
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
boundary condition: false
constant: false
notes: FORMULA: C9H13N4O8P CHARGE: -2

metaM HC02217 e
name: prostaglandin-g2
has only substance units: false
constant: false
type: Species
is: CHEBI:27647
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956

http://identifiers.org/biomodels.db/MODEL1310110053#_1111f04a_36eb_4c65_aaa0_aa0aa99a36de
is encoded by: hsa:80308
initial amount: NaN
is: Q8NFF5
name: FLAD1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false

metaR PAIL4P HStn
is described by: ECO:0000000
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
type: Reaction
reactant: MODEL1310110053#
reversible: true
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
is: SBO:0000185
kinetic law: MODEL1310110053#

metaM 2maacoa m
name: 2-methylacetoacetyl-CoA(4-)
type: Species
is: HMDB01157
is: CHEBI:57335
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344

metaM arachd e
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
type: Species
initial concentration: 1.0
name: arachidonate
is: CHEBI:32395
has only substance units: false
is: SBO:0000247
is: HMDB01043
constant: false

metaR AG13T8g
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110053#
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110053#_b549b46f_485c_47f6_9a43_7e998782f14b
has only substance units: false
initial amount: NaN
name: PECR
initial concentration: NaN
is: Q9BY49
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is encoded by: hsa:55825

metaR DOLMANP Uter
name: dolichol-phosphate mannose flippase (uterus)
product: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reversible: false
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction

metaR TCYNTt
name: Thiocyanate transport via diffusion (cytosol to extracellular)
fast: false
reactant: MODEL1310110053#
is: SBO:0000185
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM

metaR RE0944E
is version of: http://identifiers.org/ec-code/3.2.1.1
modifier: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
name: RE0944
reversible: true
product: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.17
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_0fe02bc3_9c4c_43ec_8398_f28b223534b0
name: CMPK1
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: B2R6S5
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:51727

metaM gluside hs r
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
type: Species
name: D-glucosyl-N-acylsphingosine
is: CHEBI:18368
boundary condition: false
initial amount: NaN
has only substance units: false

metaR CMPSASn
kinetic law: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
product: MODEL1310110053#
name: CMP sialic acid synthase, nuclear
type: Reaction
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.43
reactant: MODEL1310110053#
reversible: false
is described by: ECO:0000304

metaM cdpdag hs m
name: CDP-diacylglycerol(2-)
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:58332
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
initial amount: NaN
is: SBO:0000247
type: Species

metaM sphgn c
is: HMDB00269
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
boundary condition: false
initial amount: NaN
name: sphinganine(1+)
is: CHEBI:57817
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_8cea57d4_b70e_4506_b77e_982a5348ac89
name: CS
is: O75390
boundary condition: true
is encoded by: hsa:1431
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_978d63bc_b966_434e_8a1d_ecd0892dd51c
initial amount: NaN
constant: false
name: SLC35D2
has only substance units: false
is encoded by: hsa:11046
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q76EJ3

metaR r1559
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
reversible: true
product: MODEL1310110053#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM prostgi2 r
constant: false
boundary condition: false
is: HMDB01335
name: prostaglandin I2(1-)
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:57403
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312

metaR SARCStm
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
fast: false
type: Reaction
name: Sarcosine transport (mitochondrial)
reversible: false
product: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_a546966f_1c32_4ca2_bf50_6683be38b53d
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
is: Q99808
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:2030
name: SLC29A1

metaM fe3 e
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:29034
name: Fe3+
is: HMDB12943
initial amount: NaN
boundary condition: false
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
is: SBO:0000247
type: Species

metaR r0714
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110053#
fast: false
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_154cf133_09ee_4a5a_ba97_ac17f205045b
boundary condition: true
is: P22352
has only substance units: false
type: Species
name: GPX3
is encoded by: hsa:2878
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

metaM spmd c
is: SBO:0000247
type: Species
constant: false
has only substance units: false
is: C00315
is: CHEBI:57834
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB01257
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
name: Spermidine

http://identifiers.org/biomodels.db/MODEL1310110053#_9f5c446f_59f0_4da6_8cac_318c6a404638
is: Q16795
is encoded by: hsa:4704
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
name: NDUFA9
initial concentration: NaN
constant: false

metaR DHEAtr
fast: false
is described by: ECO:0000269
name: Dehydroepiandrosterone transport
is: SBO:0000185
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.8.2.2 Confidence Level: 1 AUTHORS: PMID:11535246,PMID:1588921 NOTES:
reversible: true
product: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_315c0535_3544_4044_9fb0_ee0a28c7b6d4
name: NDUFA3
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: O95167
has only substance units: false
is encoded by: hsa:4696
constant: false
type: Species
initial amount: NaN

metaR RE2269E
reactant: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
reversible: true
is version of: http://identifiers.org/ec-code/3.4.21.39
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
name: RE2269
is described by: ECO:0000000
product: MODEL1310110053#
modifier: MODEL1310110053#

metaM icit m
is: SBO:0000247
is: HMDB00193
name: Isocitrate
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
initial amount: NaN
is: CHEBI:16087
boundary condition: false
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: C00311

metaM spmd e
is: CHEBI:57834
initial concentration: 1.0
has only substance units: false
is: C00315
initial amount: NaN
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB01257
name: Spermidine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_2c1f3871_3f5a_4f3d_93da_87c91ea10e0f
initial amount: NaN
type: Species
name: NT5E
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4907
constant: false
is: P21589
initial concentration: NaN
boundary condition: true

metaR LNLNCAt
reversible: true
is described by: ECO:0000000
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000185
reactant: MODEL1310110053#
type: Reaction
fast: false

metaR r0860
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
name: Utilized transport
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/4.1.2.27
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#
reversible: true
fast: false

metaM amp r
is: CHEBI:456215
boundary condition: false
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
name: AMP
constant: false
is: HMDB00045
is: SBO:0000247
is: C00020
initial concentration: 1.0
type: Species
initial amount: NaN

metaR L LACDcm
reactant: MODEL1310110053#
is described by: ECO:0000000
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (124637.1) SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:18831974 NOTES:NCD/TDV. This reaction exists in yeast, but no evidence could be found this exists in humans. However, there may be intramitochondrial lactate dehydrogenase and lactate transport into mitochondria
kinetic law: MODEL1310110053#
name: L-Lactate dehydrogenase, cytosolic/mitochondrial
fast: false
product: MODEL1310110053#
reversible: false
is: SBO:0000185
type: Reaction

metaR 3MOX4HOXPGALDOX
is: SBO:0000176
product: MODEL1310110053#
fast: false
type: Reaction
modifier: MODEL1310110053#
is described by: ECO:0000304
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase
reactant: MODEL1310110053#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.5

http://identifiers.org/biomodels.db/MODEL1310110053#_719b893f_4bdf_4b95_9439_75353032f037
name: SLC38A3
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:10991
has only substance units: false
is: Q99624
constant: false

metaM glyb m
type: Species
is: SBO:0000247
name: glycine betaine
constant: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:17750
initial concentration: 1.0
is: HMDB00043

http://identifiers.org/biomodels.db/MODEL1310110053#_9ec6d0ed_f601_4d0c_b8e8_b6ef481abb75
boundary condition: true
is encoded by: hsa:56301
is: SBO:0000252
constant: false
is: Q9NS82
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: SLC7A10
type: Species

metaM HC02207 e
type: Species
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
initial amount: NaN
boundary condition: false
name: prostaglandin-c2
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:27555

metaR PItx
fast: false
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
name: Phosphate transporter, peroxisome
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_de91c364_5b60_4abe_8a11_a4b354af3716
initial amount: NaN
constant: false
is encoded by: hsa:8871
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: O15056
name: SYNJ2

metaM 2mpdhl m
boundary condition: false
constant: false
is: SBO:0000247
name: S-(2-Methylpropanoyl)-dihydrolipoamide
is: CHEBI:17577
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
has only substance units: false

metaR PPItx
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: Diphosphate transporter, peroxisome
reversible: true
reactant: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000185

metaR PPAt
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
is described by: ECO:0000000
reactant: MODEL1310110053#
name: Propionate transport, diffusion
type: Reaction
product: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: false

metaM hpyr c
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
has only substance units: false
is: SBO:0000247
constant: false
name: 3-hydroxypyruvate
is: CHEBI:17180
is: HMDB01352
initial amount: NaN

metaR CAROtr
is: SBO:0000185
fast: false
kinetic law: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: beta-carotene transport via diffusion
reactant: MODEL1310110053#
reversible: true
product: MODEL1310110053#
is described by: ECO:0000000

metaM glc D r
initial concentration: 1.0
name: D-glucose
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00122
is: CHEBI:4167
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
has only substance units: false
constant: false
is: SBO:0000247

metaR SERPT
modifier: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
reversible: false
is described by: ECO:0000269
name: serine C-palmitoyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.50

metaM glcur e
initial concentration: 1.0
is: HMDB00127
is: CHEBI:15748
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
name: D-glucuronate

http://identifiers.org/biomodels.db/MODEL1310110053#_2f3f160a_6e09_4e66_a9f1_ba003a841f5f
boundary condition: true
has part: P43034
is encoded by: hsa:5048
has only substance units: false
constant: false
is: SBO:0000297
name: PAFAH1B1:PAFAH1B2:PAFAH1B3
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_657e2204_2f55_46bc_9f84_4c24b061bd8d
is encoded by: hsa:T83654
name: _T83654_1_c
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_95e8f3bf_5aed_40ad_99b7_223786ceb4c1
name: GCH1
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:2643
is: Q8IZH9
constant: false
initial concentration: NaN
is: SBO:0000252

metaM m6mpdol U r
boundary condition: false
is: CHEBI:37635
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
notes: FORMULA: C1605H2640N20O520P20 CHARGE: -20

metaR r0716
product: MODEL1310110053#
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: false
fast: false
reactant: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110053#

metaM hs deg2 l
initial amount: NaN
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
has only substance units: false
name: heparan sulfate, degradation product 2
constant: false
is: HMDB01352
initial concentration: 1.0
boundary condition: false
is: CHEBI:17180
type: Species
is: SBO:0000247

metaM udp r
is: CHEBI:58223
is: C00015
has only substance units: false
boundary condition: false
is: HMDB00295
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
name: UDP
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_735a627a_1f66_4326_a0e3_924b0f95aabb
type: Species
initial amount: NaN
has only substance units: false
is: Q8N4Q0
name: ZADH2
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:284273

metaM HC00591 m
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
boundary condition: false
constant: false
name: 2-oxoglutaramate
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:16769
initial amount: NaN
has only substance units: false

metaR r0634
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is version of: http://identifiers.org/ec-code/3.1.4.1
type: Reaction
kinetic law: MODEL1310110053#
is described by: ECO:0000000
modifier: MODEL1310110053#
is: SBO:0000176
fast: false
reactant: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reversible: true

metaR r0718
is described by: ECO:0000000
is: SBO:0000176
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
type: Reaction
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.1.1.181
reversible: false
modifier: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110053#
fast: false

metaM ibcoa m
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
name: isobutyryl-CoA(4-)
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
is: SBO:0000247
constant: false
is: CHEBI:57338
has only substance units: false
is: HMDB01243

metaR r1613
is described by: ECO:0000000
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110053#

metaR r1567
fast: false
product: MODEL1310110053#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR NACHEX27ly
kinetic law: MODEL1310110053#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110053#
fast: false
product: MODEL1310110053#
reversible: false
is: SBO:0000176

metaM glcur l
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
constant: false
is: SBO:0000247
is: HMDB00127
type: Species
is: CHEBI:15748
name: D-glucuronate
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_707479f8_098d_47f1_b3b6_ad017f9e475c
has only substance units: false
name: NOS3
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is: A0S0A7
is: SBO:0000252
is encoded by: hsa:4846
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_0d99f5cc_1a88_43ec_994f_f8ed73f290e4
type: Species
initial concentration: NaN
is: SBO:0000252
is: P32189
boundary condition: true
is encoded by: hsa:2710
name: GK
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_bb068bb6_7211_4ca5_98a9_38852770fb3b
is: SBO:0000252
is encoded by: hsa:1329
initial amount: NaN
constant: false
type: Species
is: Q53YB7
name: COX5B
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR TALA
product: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.2.1.2
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
type: Reaction
name: transaldolase
modifier: MODEL1310110053#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_0c0bf400_65a2_4215_86a4_18a14014c6c4
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:50
name: ACO2
initial amount: NaN
initial concentration: NaN
is: Q99798
boundary condition: true
constant: false

metaM HC01610 e
constant: false
has only substance units: false
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
boundary condition: false
is: CHEBI:28607
initial concentration: 1.0
type: Species
name: CoproporphyrinogenI
initial amount: NaN
is: SBO:0000247

metaM core6 l
is: HMDB00143
name: Core 6
is: CHEBI:12936
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C16H27N2O10X CHARGE: 0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_1417f2d4_9219_4644_bc74_2c0a268386cb
is: P28329
boundary condition: true
constant: false
type: Species
has only substance units: false
name: CHAT
is encoded by: hsa:1103
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM tdchola x
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00951
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: CHEBI:9407
name: taurochenodeoxycholate
initial amount: NaN
type: Species

metaM 34hpp e
is: HMDB00707
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: CHEBI:36242
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
initial concentration: 1.0
boundary condition: false
name: 3-(4-hydroxyphenyl)pyruvate
has only substance units: false

metaR RE1522M
is described by: ECO:0000000
name: RE1522
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110053#_d9c18a57_add4_4c94_8f96_d5e7b2262c6e
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
is: A1L4Q0
initial amount: NaN
boundary condition: true
name: DGKE
type: Species
is encoded by: hsa:8526

metaR r1568
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM dgchol x
name: glycochenodeoxycholate
has only substance units: false
is: HMDB00637
type: Species
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial amount: NaN
initial concentration: 1.0
is: CHEBI:36252

metaR r1612
modifier: MODEL1310110053#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000185

metaM udp g
initial amount: NaN
is: CHEBI:58223
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
type: Species
has only substance units: false
is: HMDB00295
name: UDP(3-)

metaM phe L c
initial amount: NaN
is: HMDB00159
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: SBO:0000247
constant: false
is: CHEBI:17295
name: L-phenylalanine
boundary condition: false

metaR SPMTDe
kinetic law: MODEL1310110053#
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110053#
fast: false
name: SPMTDe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110053#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_6935c3b6_6261_4de4_aa20_7d2a1d627612
constant: false
boundary condition: true
name: OGDH
is encoded by: hsa:4967
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: B4E3E9

metaM 10fthf6glu e
is: CHEBI:57454
boundary condition: false
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
initial amount: NaN
name: 10-formyltetrahydrofolate-[Glu](6)
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00972
type: Species

metaM cholate e
is: CHEBI:29747
is: SBO:0000247
is: HMDB00619
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
name: Cholate
boundary condition: false
type: Species
has only substance units: false

metaM arachd r
is: CHEBI:32395
type: Species
initial concentration: 1.0
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: SBO:0000247
boundary condition: false
is: HMDB01043
initial amount: NaN
has only substance units: false
constant: false
name: arachidonate

metaR GLCNACASE1ly
is: SBO:0000176
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.2.1.50
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
fast: false
kinetic law: MODEL1310110053#
name: alpha-N-acetylglucosaminidase, lysosomal
modifier: MODEL1310110053#
type: Reaction
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110053#

metaM bilglcur e
has only substance units: false
is: CHEBI:57767
initial amount: NaN
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
name: mono(glucosyluronic acid)bilirubin(2-)
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_066e43a9_5b63_4a57_b2dc_e31bbbbf7c06
initial amount: NaN
has only substance units: false
name: SLC6A5
initial concentration: NaN
constant: false
is: Q9Y345
is encoded by: hsa:9152
is: SBO:0000252
type: Species
boundary condition: true

metaR ADSK
is version of: http://identifiers.org/ec-code/2.7.1.25
reversible: false
kinetic law: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
fast: false
product: MODEL1310110053#
is: SBO:0000176
is described by: ECO:0000269
name: adenylyl-sulfate kinase
modifier: MODEL1310110053#

metaM met L c
name: L-methionine
is: HMDB00696
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
has only substance units: false
is: CHEBI:16643
initial amount: NaN

metaR r0571
is: SBO:0000176
name: (S)-Methylmalonyl-CoA hydrolase Propanoate metabolism EC:3.1.2.17
product: MODEL1310110053#
fast: false
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.8
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.17 Confidence Level: 0 AUTHORS: PMID:3071714,PMID:6885824 NOTES:
modifier: MODEL1310110053#
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000000

metaR CYTK9
name: cytidylate kinase (CMP,dCTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
product: MODEL1310110053#
fast: false
is: SBO:0000176

metaR GALK
name: galactokinase
fast: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.6
reactant: MODEL1310110053#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.1.157
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#

metaR r1615
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
is: SBO:0000185
fast: false
modifier: MODEL1310110053#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110053#

metaM prpncoa m
name: acryloyl-CoA(4-)
initial concentration: 1.0
is: CHEBI:57367
constant: false
initial amount: NaN
is: HMDB02307
is: SBO:0000247
has only substance units: false
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
boundary condition: false
type: Species

metaR GLYt2r
reversible: true
is described by: ECO:0000304
type: Reaction
fast: false
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
name: glycine reversible transport via proton symport
modifier: MODEL1310110053#
is: SBO:0000185
product: MODEL1310110053#

metaR r1569
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110053#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110053#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110053#

metaR r0797
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
modifier: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110053#
name: glycine N-choloyltransferase EC:2.3.1.65
fast: false
reversible: true
is: SBO:0000176
is described by: ECO:0000000

metaR r2419
type: Reaction
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185
product: MODEL1310110053#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_c1f49795_efce_436f_85e1_42e9388e6fca
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:37
is: P49748
name: ACADVL
is: SBO:0000252

metaR 10FTHFtm
type: Reaction
reactant: MODEL1310110053#
reversible: true
product: MODEL1310110053#
is: SBO:0000185
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110053#
fast: false

metaR PPCOAOm
type: Reaction
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
product: MODEL1310110053#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110053#
is: SBO:0000176
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110053#

metaM leuktrF4 e
constant: false
is: HMDB06465
name: leukotriene F4
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:27491
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
has only substance units: false

metaR CERT1rt
is described by: ECO:0000304
reversible: true
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110053#
name: ceramide transport protein
kinetic law: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
is: SBO:0000185
product: MODEL1310110053#
fast: false

metaM f1a g
is: SBO:0000247
has only substance units: false
is: CHEBI:17151
name: F1alpha
boundary condition: false
notes: FORMULA: C22H37N2O15X CHARGE: 0
initial concentration: 1.0
is: HMDB02917
type: Species
initial amount: NaN
constant: false

metaM leu L e
is: CHEBI:15603
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
constant: false
initial concentration: 1.0
is: HMDB00687
name: L-leucine
has only substance units: false

metaM clpndcoa c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: C16166
name: clupanodonyl CoA
is: HMDB06267
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/47205476
boundary condition: false

metaR r0573
type: Reaction
name: Cholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:438652 NOTES:
product: MODEL1310110053#
reversible: true
kinetic law: MODEL1310110053#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110053#
is: SBO:0000176

metaR r1614
type: Reaction
modifier: MODEL1310110053#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110053#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR DIGALSGALSIDEte
name: digalsgalside hs transport
reactant: MODEL1310110053#
fast: false
type: Reaction
product: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
kinetic law: MODEL1310110053#
reversible: true

metaR r1400
name: Active transport
fast: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
type: Reaction
reactant: MODEL1310110053#
is described by: ECO:0000000

metaM 34hpp c
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00707
constant: false
is: CHEBI:36242
initial amount: NaN
initial concentration: 1.0
name: 3-(4-hydroxyphenyl)pyruvate

http://identifiers.org/biomodels.db/MODEL1310110053#_172d483e_4499_4118_8d8f_f2fe267751ea
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species
name: CPT1B
initial amount: NaN
is encoded by: hsa:1375
has only substance units: false
is: B7Z5T8

metaR SUCCt4 2
reactant: MODEL1310110053#
modifier: MODEL1310110053#
name: succinate transport via sodium symport
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
reversible: true
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_8c10c883_1edf_4c5b_8f0b_c7390f4216cb
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
constant: false
name: COX6A2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1339
is: Q02221

metaR FUMtm
is: SBO:0000185
modifier: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true
type: Reaction
kinetic law: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
is described by: ECO:0000269
name: fumarate transport, mitochondrial
fast: false

metaM met L e
type: Species
constant: false
name: L-methionine
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: CHEBI:16643
has only substance units: false
is: HMDB00696

metaM bhb c
has only substance units: false
name: (R)-3-hydroxybutyrate
is: HMDB00011
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: CHEBI:10983
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
type: Species

metaM bilglcur c
is: SBO:0000247
is: CHEBI:57767
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
name: mono(glucosyluronic acid)bilirubin(2-)
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
has only substance units: false

metaM fadh2 c
name: FADH2(2-)
initial amount: NaN
boundary condition: false
is: HMDB01197
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
is: CHEBI:58307
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_2016abe4_3146_4604_af4f_5ba807a2b6d7
is encoded by: hsa:23632
is: SBO:0000252
boundary condition: true
has only substance units: false
name: CA14
constant: false
initial amount: NaN
is: A8K3J4
initial concentration: NaN
type: Species

metaM Rtotal2 e
initial amount: NaN
boundary condition: false
name: R total 2 position
is: CHEBI:3554
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: C00255
is: HMDB00244
initial concentration: 1.0
has only substance units: false

metaM udp l
name: UDP(3-)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: CHEBI:58223
is: SBO:0000247
constant: false
type: Species
is: HMDB00295
has only substance units: false
initial amount: NaN

metaR r1563
reversible: true
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110053#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110053#
fast: false
is: SBO:0000185

metaM ksi pre30 g
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 30
initial amount: NaN
type: Species
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
is: CHEBI:58053
is: SBO:0000247
initial concentration: 1.0
constant: false
is: C00130
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_c73205d4_4296_40dd_a2af_a9e90fcd446f
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110053#_578aab6a_6796_4d55_aaba_612aa1fdbe38
is encoded by: hsa:3417
name: IDH1
is: O75874
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false

metaR r0630
modifier: MODEL1310110053#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000000
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.3.1
product: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.2

metaR PROSTGH2t
fast: false
reversible: true
name: Prostaglandin H2 transport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
reactant: MODEL1310110053#
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_fddea608_6891_474c_884a_b58e806af4e8
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:5333
has only substance units: false
is: P51178
name: PLCD1
initial amount: NaN
type: Species

metaM taur x
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
is: HMDB00251
is: SBO:0000247
initial concentration: 1.0
name: taurine
is: CHEBI:15891
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: false

metaM leuktrF4 c
is: HMDB06465
constant: false
name: leukotriene F4
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:27491
initial amount: NaN
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_3366a4d3_9f6c_484d_af85_65356711472e
type: Species
boundary condition: true
is: Q16881
name: TXNRD1
is: SBO:0000252
is encoded by: hsa:7296
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_09a66fde_fd1f_4e93_94b4_90d9ab0fca21
initial concentration: NaN
has only substance units: false
name: ALDH7A1
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: E7EPT3
is encoded by: hsa:501
type: Species

metaR r2026
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
is: SBO:0000185
product: MODEL1310110053#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_6e497d6f_3990_4781_a25c_2c35f80abd2d
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:5091
initial concentration: NaN
boundary condition: true
name: PC
is: P11498

metaR AMPtp
product: MODEL1310110053#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110053#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
name: AMP transporter, peroxisome
is: SBO:0000185
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_4b61ccaf_0299_4bff_ae08_4f770181d8d0
has only substance units: false
boundary condition: true
name: _R39999_1_c
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:R39999
initial concentration: NaN

metaM ala B e
type: Species
is: HMDB00056
constant: false
name: beta-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16958
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_5b760825_f74d_4ed9_a0b9_f7810a06f315
has only substance units: false
boundary condition: true
initial amount: NaN
is: P31040
is encoded by: hsa:6389
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: SDHA

http://identifiers.org/biomodels.db/MODEL1310110053#_aacfa11d_c937_457a_8f69_b5bfa65b2893
boundary condition: true
constant: false
has only substance units: false
is: B4DUG1
type: Species
name: SLC24A1
is encoded by: hsa:9187
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR r1564
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110053#
fast: false
is: SBO:0000185
product: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_e4ec103e_341d_42e5_9916_491e23245e55
is encoded by: hsa:AU149534
initial concentration: NaN
is: SBO:0000252
name: _AU149534_1_e
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
type: Species

metaR ASCBt
reversible: true
type: Reaction
reactant: MODEL1310110053#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
name: L-ascorbate transport via facilitated diffusion
is: SBO:0000185
product: MODEL1310110053#

metaM tyr L c
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
type: Species
name: L-tyrosine
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17895
is: HMDB00158
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085

metaR ICDHy
kinetic law: MODEL1310110053#
type: Reaction
name: isocitrate dehydrogenase (NADP)
reactant: MODEL1310110053#
product: MODEL1310110053#
reversible: false
notes: GENE_ASSOCIATION: (3417.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES:Two reactions (ICDH1 and ICDH2) for isocitrate dehydrogenase
is version of: http://identifiers.org/ec-code/1.1.1.42
modifier: MODEL1310110053#
is described by: ECO:0000269
fast: false
is: SBO:0000176

metaR r0575
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.1.48
reactant: MODEL1310110053#
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#

metaM chsterol r
is: CHEBI:16113
name: cholesterol
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: HMDB00067
type: Species

metaR PAIL HStn
reversible: true
product: MODEL1310110053#
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: phosphatidylinositol nuclear transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#

metaR RE3326M
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true
is described by: ECO:0000000
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
name: RE3326
modifier: MODEL1310110053#
fast: false
is version of: http://identifiers.org/ec-code/1.2.4.4
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_a98e583b_b0ba_41d3_9215_8af482f88918
has only substance units: false
is: P10696
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:251
name: ALPPL2
type: Species

metaM hs deg17 l
is: CHEBI:21338
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
is: HMDB02704
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
name: heparan sulfate, degradation product 17

http://identifiers.org/biomodels.db/MODEL1310110053#_0bc49365_566f_4885_8e47_92596943805b
initial amount: NaN
type: Species
is encoded by: hsa:9963
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
name: SLC23A1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_ac4c6706_8718_4f5e_bd59_1ca487508c61
name: LDHB
is encoded by: hsa:3945
boundary condition: true
type: Species
is: P07195
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_ed13273d_5aaa_4082_a1b9_a79b0c935728
name: _H45672_1_m
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:H45672
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_2cbadf94_692a_47ac_8cd0_dbefd53b0d06
is: Q9Y259
has only substance units: false
is encoded by: hsa:1120
boundary condition: true
name: CHKB
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
initial amount: NaN

metaM urate c
is: HMDB00289
initial amount: NaN
is: C00366
name: Urate
has only substance units: false
type: Species
is: CHEBI:17775
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false

metaM amp x
name: AMP
initial amount: NaN
boundary condition: false
is: HMDB00045
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial concentration: 1.0
is: C00020
type: Species
is: CHEBI:456215
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_f9de3fc3_d3d3_49a7_8962_e37a1da08f31
name: PLCG2
type: Species
constant: false
boundary condition: true
is encoded by: hsa:5336
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P16885
initial concentration: NaN

metaR r1611
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR r1565
kinetic law: MODEL1310110053#
reversible: true
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM Rtotal2 c
name: R total 2 position
boundary condition: false
is: HMDB00095
initial amount: NaN
type: Species
notes: FORMULA: CO2FULLR2 CHARGE: -1
constant: false
is: SBO:0000247
is: CHEBI:60377
initial concentration: 1.0
has only substance units: false
is: C00055

metaM core6 g
is: C04383
constant: false
boundary condition: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
name: Core 6
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaM cit m
is: CHEBI:16947
name: Citrate
is: C00158
is: HMDB00094
initial concentration: 1.0
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
constant: false

metaR r0578
reversible: true
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is version of: http://identifiers.org/ec-code/4.1.2.27
reactant: MODEL1310110053#
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110053#
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#

metaR RADH
reactant: MODEL1310110053#
reversible: true
type: Reaction
name: retinal dehydrogenase
is described by: ECO:0000000
kinetic law: MODEL1310110053#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_8c64e45d_c156_4d95_89d6_1c9fa696d34f
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: P47895
is: SBO:0000252
constant: false
name: ALDH1A3
is encoded by: hsa:220
type: Species
boundary condition: true

metaR NCNt
is: SBO:0000185
reactant: MODEL1310110053#
fast: false
name: Na+/Ca2+-NH4+ exchange
kinetic law: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110053#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_e2d11562_bdfa_44cc_b764_d35a69c27f6b
is: P49448
initial concentration: NaN
type: Species
name: GLUD2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2747
has only substance units: false
initial amount: NaN
constant: false

metaM orot e
constant: false
is: HMDB00226
boundary condition: false
initial concentration: 1.0
is: CHEBI:30839
has only substance units: false
type: Species
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
name: orotate
is: SBO:0000247
initial amount: NaN

metaM 3mop c
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
constant: false
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
is: CHEBI:28654
is: HMDB00491

metaR r1492
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: false
is: SBO:0000185
reactant: MODEL1310110053#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110053#
product: MODEL1310110053#
name: Utilized transport

metaM ala B c
type: Species
is: HMDB00056
constant: false
name: beta-alanine
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:16958

metaM digalside hs c
initial concentration: 1.0
is: C06126
is: http://identifiers.org/pubchem.compound/8383
is: SBO:0000247
name: Digalactosylceramide
type: Species
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126

metaM retn c
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: CHEBI:35291
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB01852
initial amount: NaN
has only substance units: false
name: all-trans-retinoate

metaR G14T2g
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110053#
modifier: MODEL1310110053#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
kinetic law: MODEL1310110053#
product: MODEL1310110053#

metaR r1610
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_4f8a4e51_13ff_4048_96d5_ed7b621f49b0
is: P10619
boundary condition: true
name: CTSA
is encoded by: hsa:5476
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_31cdccb8_60ac_4ab4_80c5_7372cb2a482a
type: Species
has only substance units: false
is encoded by: hsa:48
initial amount: NaN
is: SBO:0000252
is: P21399
constant: false
name: ACO1
initial concentration: NaN
boundary condition: true

metaR r1566
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_851ad2a5_962a_4563_906e_46608246ff56
has only substance units: false
is encoded by: hsa:6817
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: SULT1A1
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_ad449e86_d45f_47a0_9e4f_5a6583e926df
initial concentration: NaN
is encoded by: hsa:6560
initial amount: NaN
is: F5H066
boundary condition: true
name: SLC12A4
has only substance units: false
constant: false
type: Species
is: SBO:0000252

metaM tyr L e
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00158
constant: false
is: CHEBI:17895
type: Species
boundary condition: false
has only substance units: false
name: L-tyrosine

metaR CLOXAtex2
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
fast: false
type: Reaction
name: chloride transport via oxalate countertransport (2:1)
product: MODEL1310110053#
reversible: false
is: SBO:0000185
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000304
reactant: MODEL1310110053#

metaM phe L e
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
constant: false
is: SBO:0000247
is: CHEBI:17295
initial concentration: 1.0
type: Species
is: HMDB00159
boundary condition: false
initial amount: NaN
has only substance units: false
name: L-phenylalanine

metaR r0360
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.16
is described by: ECO:0000000
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000176
fast: false
modifier: MODEL1310110053#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
type: Reaction

metaM udpacgal c
has only substance units: false
is: HMDB00304
boundary condition: false
constant: false
name: UDP-N-acetyl-D-galactosamine(2-)
type: Species
initial concentration: 1.0
is: CHEBI:57847
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial amount: NaN
is: SBO:0000247

metaM 7dhf e
name: heptaglutamyl folate (DHF)
initial amount: NaN
is: HMDB06559
constant: false
type: Species
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM cholate c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: CHEBI:29747
boundary condition: false
is: HMDB00619
has only substance units: false
constant: false
initial amount: NaN
name: Cholate
type: Species

metaR NNATr
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
fast: false
is described by: ECO:0000269
is: SBO:0000176
reversible: true
type: Reaction
product: MODEL1310110053#
name: nicotinate-nucleotide adenylyltransferase
notes: GENE_ASSOCIATION: (349565.1) or (23057.2) or (23057.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.7.18 Confidence Level: 4 AUTHORS: PMID:12574164,PMID:14516279 NOTES:JLR
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.7.1

metaM urate e
is: C00366
type: Species
name: Urate
is: CHEBI:17775
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
initial concentration: 1.0
constant: false
is: HMDB00289
initial amount: NaN
boundary condition: false

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

metaR GLYtm
type: Reaction
reactant: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
kinetic law: MODEL1310110053#
reversible: true
name: glycine passive transport to mitochondria

metaM akg e
constant: false
name: 2-oxoglutarate(2-)
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:16810
is: HMDB00208
type: Species
initial amount: NaN
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026

metaR CYTK2
is described by: ECO:0000269
name: cytidylate kinase (dCMP)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110053#
reversible: true
reactant: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110053#
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_5e46dcf2_2ea1_4491_b58b_d514b53ba855
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:29920
has only substance units: false
boundary condition: true
is: Q96C36
initial concentration: NaN
initial amount: NaN
name: PYCR2

http://identifiers.org/biomodels.db/MODEL1310110053#_7c6d43f2_b48b_4d81_98a4_a2a5460925ae
is: Q9NZ20
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:50487
type: Species
initial amount: NaN
has only substance units: false
name: PLA2G3

metaR r0085
modifier: MODEL1310110053#
type: Reaction
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
kinetic law: MODEL1310110053#
reversible: false
reactant: MODEL1310110053#
product: MODEL1310110053#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.42
is described by: ECO:0000000

metaR r2357
reactant: MODEL1310110053#
name: Organic anion transporter 5 Utilized transport
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185

metaR r0002
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
product: MODEL1310110053#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: Active transport
kinetic law: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_d3289071_058a_4101_becb_033674653c19
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:6536
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
is: B7Z3W8
name: SLC6A9

metaM thyox L e
boundary condition: false
name: L-thyroxine
has only substance units: false
is: CHEBI:18332
is: HMDB00248
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_b6899e76_be27_4578_958b_9891fabd8ed5
name: SLC24A4
is: SBO:0000252
constant: false
is encoded by: hsa:123041
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_de4dfb4d_22b7_44db_a4d3_344069644e54
initial concentration: NaN
constant: false
is: Q6PXP3
is encoded by: hsa:155184
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: SLC2A7
type: Species

metaM ksi pre2 g
boundary condition: false
initial amount: NaN
is: HMDB00175
notes: FORMULA: C87H142N6O62X CHARGE: -1
is: C00130
type: Species
constant: false
name: keratan sulfate I biosynthesis, precursor 2
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:58053

metaR PPItm
kinetic law: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
fast: false
is described by: ECO:0000134
is: SBO:0000185
name: diphopshate transporter, mitochondrial
type: Reaction
reactant: MODEL1310110053#
reversible: true

metaM ksi pre20 g
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
is: CHEBI:28067
has only substance units: false
constant: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 20
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR r2136
is described by: ECO:0000000
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
reversible: false
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
fast: false
product: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

metaR CYTK1
product: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110053#
name: cytidylate kinase (CMP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM gluside hs g
has only substance units: false
is: CHEBI:18368
type: Species
constant: false
boundary condition: false
name: D-glucosyl-N-acylsphingosine
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190

metaR r1560
reactant: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110053#
is described by: ECO:0000000
fast: false
product: MODEL1310110053#
type: Reaction

metaM ksii core2 pre7 g
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00175
is: CHEBI:58053
is: C00130
notes: FORMULA: C67H108N5O51SX CHARGE: -2
constant: false
name: keratan sulfate II biosynthesis, precursor 7
has only substance units: false

metaM C05957 r
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
has only substance units: false
is: HMDB02710
initial concentration: 1.0
is: CHEBI:27485
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
name: Prostaglandin J2

metaR PRO Dtde
is: SBO:0000185
product: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000134
name: D-proline transport, extracellular
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
kinetic law: MODEL1310110053#

metaM retn e
type: Species
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
constant: false
has only substance units: false
is: HMDB01852
is: SBO:0000247
initial concentration: 1.0
name: all-trans-retinoate
is: CHEBI:35291
boundary condition: false
initial amount: NaN

metaR MM5cg
kinetic law: MODEL1310110053#
is: SBO:0000176
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.113
reactant: MODEL1310110053#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
modifier: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
is described by: ECO:0000000

metaR r2358
is described by: ECO:0000000
reactant: MODEL1310110053#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reversible: true
type: Reaction
is: SBO:0000185

metaR EX dgsn LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyguanosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_74665b8a_b09e_4065_93c8_14e113c7d4fb
boundary condition: true
is: A8K7W0
constant: false
is encoded by: hsa:8875
type: Species
has only substance units: false
name: VNN2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_872788ce_d760_4b5b_a42c_59366f0e073e
is encoded by: hsa:4700
name: NDUFA6
type: Species
has only substance units: false
boundary condition: true
is: P56556
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM fadh2 m
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB01197
type: Species
name: Flavin adenine dinucleotide reduced
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
has only substance units: false
initial amount: NaN
is: C01352
is: CHEBI:58307

http://identifiers.org/biomodels.db/MODEL1310110053#_150c3d42_10cf_4f81_930f_84c74c10ce6d
name: ATP8A1
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is: Q9Y2Q0
is encoded by: hsa:10396
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_7c8c3ef5_761c_4695_9777_2e4120340084
boundary condition: true
name: SLC17A5
is encoded by: hsa:26503
initial concentration: NaN
is: SBO:0000252
is: Q9NRA2
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaM glcur r
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: SBO:0000247
name: D-glucuronate
is: HMDB00127
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:15748
has only substance units: false
boundary condition: false

metaR r1561
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaM digalside hs g
initial amount: NaN
name: Digalactosylceramide
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
has only substance units: false
is: http://identifiers.org/pubchem.compound/8383
is: C06126

metaR r2137
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
product: MODEL1310110053#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
modifier: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_81aed2ae_25b2_47ac_95bb_b645ba7b1603
boundary condition: true
is encoded by: hsa:1606
initial amount: NaN
has only substance units: false
is: P23743
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: DGKA

metaM akg c
is: HMDB00208
initial amount: NaN
name: 2-Oxoglutarate
is: C00026
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:16810
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
type: Species

metaR CYTK4
fast: false
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000269
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
name: cytidylate kinase (dCMP)(GTP)
type: Reaction
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#

metaM accoa c
is: SBO:0000247
initial concentration: 1.0
is: C00024
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial amount: NaN
has only substance units: false
name: Acetyl-CoA
type: Species
constant: false
boundary condition: false
is: HMDB01206
is: CHEBI:57288

metaR CTPtn
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
name: CTP diffusion in nucleus
is: SBO:0000185
type: Reaction
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true
product: MODEL1310110053#

metaM dkmpp c
is: C15650
is: SBO:0000247
name: 2,3-diketo-5-methylthio-1-phosphopentane
notes: FORMULA: C6H9O6PS CHARGE: -2
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58828
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_5eb7c5cf_4de0_4b76_bb27_f4cda14fb8c1
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:175
type: Species
name: AGA
initial concentration: NaN
is: P20933

metaR r0083
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
type: Reaction
reactant: MODEL1310110053#
fast: false
is: SBO:0000176
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is version of: http://identifiers.org/ec-code/1.1.1.42
product: MODEL1310110053#
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
reversible: true

metaM CE2250 e
name: 3-oxodocosanoyl-CoA
is: CHEBI:52328
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C43H72N7O18P3S CHARGE: -4 INCHI: InChI=1S/C43H76N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-31(51)26-34(53)72-25-24-45-33(52)22-23-46-41(56)38(55)43(2,3)28-65-71(62,63)68-70(60,61)64-27-32-37(67-69(57,58)59)36(54)42(66-32)50-30-49-35-39(44)47-29-48-40(35)50/h29-30,32,36-38,42,54-55H,4-28H2,1-3H3,(H,45,52)(H,46,56)(H,60,61)(H,62,63)(H2,44,47,48)(H2,57,58,59)/t32-,36-,37-,38+,42-/m1/s1 EHMN_ABBREVIATION: CE2250
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR r2359
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110053#
reversible: true
name: Organic anion transporter 5 Utilized transport

metaM doldp U r
type: Species
notes: FORMULA: C1025H1670O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
is: SBO:0000247
initial concentration: 1.0
name: Dolichol diphosphate, human uterine homolog
is: CHEBI:15750
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false

metaM chsterol m
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: HMDB00067
name: cholesterol
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:16113
initial amount: NaN

metaR TRPt
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
name: L-tryptophan transport
fast: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true
is: SBO:0000185
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#

metaM cdpdag hs c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
name: CDP-diacylglycerol(2-)
type: Species
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:58332

metaR UDPGLCAter
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
kinetic law: MODEL1310110053#
fast: false
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
reversible: true
reactant: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110053#
type: Reaction

metaR r1562
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_e4a99141_6af9_47aa_9bf2_05fc688b24e7
name: SLC22A1
initial amount: NaN
is encoded by: hsa:6580
is: O15245
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252

metaR GLYtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110053#
name: glycine passive transport to peroxisome
product: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#

metaR CYTK3
is: SBO:0000176
product: MODEL1310110053#
reversible: true
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
is described by: ECO:0000269
name: cytidylate kinase (CMP)(GTP)
type: Reaction
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
fast: false

metaR MI4PP
name: myo-inositol 4-phosphatase
is described by: ECO:0000269
type: Reaction
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.1.3.25
modifier: MODEL1310110053#
reversible: false
fast: false
kinetic law: MODEL1310110053#
is: SBO:0000176

metaM udpacgal g
is: HMDB00304
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: CHEBI:57847
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
name: UDP-N-acetyl-D-galactosamine(2-)
type: Species
has only substance units: false

metaR PAPStg
fast: false
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true
name: 3'-Phosphoadenylyl sufate Golgi transport
type: Reaction
product: MODEL1310110053#
is described by: ECO:0000269
reactant: MODEL1310110053#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110053#_c80472e5_ed88_4bdb_8e7e_9372962f7265
name: LDHC
has only substance units: false
is: P07864
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:3948
constant: false
is: SBO:0000252

metaM naglc2p U c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1105H1810N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
is: CHEBI:18278
has only substance units: false

metaR BCDO
notes: GENE_ASSOCIATION: (53630.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.14.99.36 Confidence Level: 4 AUTHORS: PMID:10799297,PMID:11401432,PMID:1503811 NOTES:IT
reactant: MODEL1310110053#
fast: false
reversible: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.99.36
is described by: ECO:0000269
modifier: MODEL1310110053#
name: beta-Carotene dioxygenase
product: MODEL1310110053#
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_4de80655_0e19_4b86_b733_f0cbc738349d
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10423
is: O14735
name: CDIPT
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR RE2349C
is described by: ECO:0000000
name: RE2349
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.64
reversible: true
fast: false
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
is: SBO:0000176
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#

metaR DCYTDn
is described by: ECO:0000254
fast: false
product: MODEL1310110053#
name: deoxycytidine deaminase, nuclear
kinetic law: MODEL1310110053#
reversible: false
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.5.4.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
type: Reaction
modifier: MODEL1310110053#

metaR GALt4
modifier: MODEL1310110053#
reversible: true
product: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
kinetic law: MODEL1310110053#
is described by: ECO:0000269
type: Reaction
name: galactose transport via sodium symport
reactant: MODEL1310110053#
fast: false

metaM chsterol l
is: SBO:0000247
type: Species
is: HMDB00067
boundary condition: false
is: CHEBI:16113
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: cholesterol

metaR r1872
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110053#
reversible: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#

metaR CYTK12n
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110053#
name: cytidylate kinase (dCMP,dCTP),nuclear
modifier: MODEL1310110053#
is described by: ECO:0000269
reactant: MODEL1310110053#
fast: false
reversible: true
kinetic law: MODEL1310110053#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM hs deg7 l
name: heparan sulfate, degradation product 7
is: CHEBI:17180
is: HMDB01352
boundary condition: false
constant: false
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_893af1df_de27_4c9d_b2f8_64c8bbc86eaa
name: MAN2A2
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:4122
is: Q9P1E4
initial concentration: NaN

metaM leuktrE4 e
is: HMDB02200
initial amount: NaN
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
name: leukotriene E4(1-)
boundary condition: false
initial concentration: 1.0
is: CHEBI:57462
constant: false
has only substance units: false
is: SBO:0000247
type: Species

metaR r1260
product: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: false
name: EC:6.2.1.3

metaR r2353
reactant: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110053#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reversible: true

metaM ala B m
name: beta-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
boundary condition: false
is: HMDB00056
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16958
type: Species
is: SBO:0000247
constant: false

metaR CYTK6
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
is: SBO:0000176
is described by: ECO:0000269
name: cytidylate kinase (CMP,CTP)
reactant: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110053#
product: MODEL1310110053#

metaM udp c
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:58223
is: C00015
constant: false
type: Species
is: HMDB00295
is: SBO:0000247
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial amount: NaN
name: UDP

metaM Lkynr c
is: SBO:0000247
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
is: CHEBI:16946
name: L-kynurenine
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00684
has only substance units: false
initial amount: NaN

metaM cit c
name: Citrate
is: SBO:0000247
is: CHEBI:16947
constant: false
initial concentration: 1.0
is: HMDB00094
type: Species
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: C00158
initial amount: NaN
boundary condition: false

metaR r2139
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110053#
is: SBO:0000185
modifier: MODEL1310110053#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
kinetic law: MODEL1310110053#
reversible: true
type: Reaction
reactant: MODEL1310110053#

metaR UDPGLCter
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
product: MODEL1310110053#
is: SBO:0000185
reversible: true
reactant: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
fast: false

metaM fadh2 r
is: HMDB01197
is: CHEBI:58307
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
has only substance units: false
name: FADH2(2-)

metaR r0638
type: Reaction
is described by: ECO:0000000
product: MODEL1310110053#
is: SBO:0000176
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true
reactant: MODEL1310110053#
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is version of: http://identifiers.org/ec-code/2.8.1.2
fast: false
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:

metaR HIStN1
reversible: true
reactant: MODEL1310110053#
product: MODEL1310110053#
fast: false
name: Histidine transport (Na, H coupled)
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110053#

metaM dhea r
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
type: Species
boundary condition: false
constant: false
is: SBO:0000247
name: 3beta-hydroxyandrost-5-en-17-one
initial amount: NaN
has only substance units: false
is: HMDB00077
initial concentration: 1.0
is: CHEBI:28689

metaM hs deg20 l
initial amount: NaN
type: Species
is: CHEBI:16126
has only substance units: false
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
constant: false
name: heparan sulfate, degradation product 20
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR r1617
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
modifier: MODEL1310110053#
product: MODEL1310110053#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_ef49e2cf_cf33_4c76_b976_e803eab9ebf5
constant: false
initial amount: NaN
name: ACADM
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:34
is: P11310

metaR r0365
is described by: ECO:0000000
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: false
product: MODEL1310110053#
fast: false
is: SBO:0000176
reactant: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.72

http://identifiers.org/biomodels.db/MODEL1310110053#_405b3a05_8340_4705_9f0b_1e2f5460dfff
has only substance units: false
initial amount: NaN
is encoded by: hsa:60490
type: Species
is: Q96CD2
name: PPCDC
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_87042a29_22ac_489f_b2fd_a5dd386cd0c1
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:8801
is: Q96I99
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
name: SUCLG2

metaR r2354
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110053#
is: SBO:0000185
reversible: true
product: MODEL1310110053#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110053#

metaM ksi pre18 g
initial amount: NaN
is: C00130
is: CHEBI:58053
notes: FORMULA: C163H262N11O132S5X CHARGE: -6
boundary condition: false
is: HMDB00175
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 18
has only substance units: false
constant: false
type: Species
initial concentration: 1.0

metaR CYTK5
is: SBO:0000176
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
modifier: MODEL1310110053#
name: cytidylate kinase (dCMP)
is described by: ECO:0000269
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#

metaM CE2424 m
boundary condition: false
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
is: SBO:0000247
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
has only substance units: false
is: CHEBI:28387
initial concentration: 1.0
constant: false
is: HMDB11123
initial amount: NaN
type: Species

metaR LPS3e
type: Reaction
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.1.3
reversible: false
kinetic law: MODEL1310110053#
is: SBO:0000176
product: MODEL1310110053#
is described by: ECO:0000000
modifier: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
name: lipase, extracellular

http://identifiers.org/biomodels.db/MODEL1310110053#_bd05163e_bd6d_4e09_99c8_2b05954f977b
name: FUT8
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:2530
type: Species
initial concentration: NaN
is: B4DFS7
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_56710584_521f_46cf_a662_a17f7265db98
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: _AI091231_1_c
initial concentration: NaN
is encoded by: hsa:AI091231
constant: false
is: SBO:0000252

metaM gluside hs c
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:18368
is: SBO:0000247
boundary condition: false
name: D-glucosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial amount: NaN

metaR r0639
is: SBO:0000176
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
reversible: false
product: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:

metaM 3hmp m
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
type: Species
constant: false
is: HMDB00023
initial concentration: 1.0
is: CHEBI:11805
boundary condition: false
has only substance units: false
name: 3-hydroxy-2-methylpropanoate
is: SBO:0000247
initial amount: NaN

metaM o2 c
name: O2
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
type: Species
boundary condition: false
constant: false
is: CHEBI:15379
is: HMDB01377
is: SBO:0000247
is: C00007
initial amount: NaN
initial concentration: 1.0

metaR GLYSNAT5tc
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR r1616
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110053#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaM trdrd c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: Reduced thioredoxin
is: C00342
boundary condition: false
constant: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
is: CHEBI:15967
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_304ee9f4_a68b_4708_b1bd_02f9e698b1df
is: SBO:0000252
name: CHAT
initial amount: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
is: D3DX95
initial concentration: NaN
is encoded by: hsa:1103

metaM leu L c
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
name: L-leucine
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00687
has only substance units: false
is: CHEBI:15603

metaR r0410
product: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19

metaR DNDPt15m
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110053#
fast: false
reversible: false
product: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
name: dUDP transport via dGDP antiport

metaR S6T14g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110053#
is: SBO:0000176
product: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaR CYTK8
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110053#
modifier: MODEL1310110053#
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000269
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
name: cytidylate kinase (CMP,dATP)

metaR r1262
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: false
reactant: MODEL1310110053#
name: EC:6.2.1.3
fast: false
type: Reaction
is described by: ECO:0000000

metaM glyc S e
has only substance units: false
is: CHEBI:33871
constant: false
boundary condition: false
notes: FORMULA: C3H5O4 CHARGE: 0
type: Species
initial concentration: 1.0
name: (S)-Glycerate
initial amount: NaN
is: SBO:0000247
is: HMDB06372

metaR NADPHtru
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
is: SBO:0000185
product: MODEL1310110053#
name: NADPH transporter, endoplasmic reticulum
fast: false

metaM cit e
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
name: citrate(3-)
is: CHEBI:16947
is: HMDB00094
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_50ef022f_727c_43b2_94e8_ae17585f8df7
constant: false
name: COX1
is: SBO:0000252
type: Species
is encoded by: hsa:4512
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q7GXY8

metaM thyox L c
is: CHEBI:18332
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00248
initial concentration: 1.0
has only substance units: false
type: Species
name: L-thyroxine
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849

http://identifiers.org/biomodels.db/MODEL1310110053#_8e1f94d9_4ada_453e_b0eb_c64bf242fe8e
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: B4DX62
constant: false
name: ST3GAL3
is encoded by: hsa:6487

http://identifiers.org/biomodels.db/MODEL1310110053#_5f067016_2435_4440_875e_92db717c70ad
is encoded by: hsa:19
has only substance units: false
is: SBO:0000252
is: O95477
constant: false
initial concentration: NaN
name: ABCA1
initial amount: NaN
boundary condition: true
type: Species

metaR r1619
type: Reaction
reactant: MODEL1310110053#
reversible: true
is: SBO:0000185
product: MODEL1310110053#
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110053#_bb144fa0_dc4a_4832_a1c0_3fb74b9fd8b7
name: SUOX
type: Species
is: P51687
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6821
initial concentration: NaN
initial amount: NaN

metaM HC00319 c
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:30794
boundary condition: false
constant: false
initial concentration: 1.0
name: Malonate
has only substance units: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)

metaR r2355
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110053#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport

metaR r0086
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.3
reversible: false
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_0d409432_31f7_49a4_bd37_52cf8e9475bb
constant: false
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: DPYSL3
is encoded by: hsa:1809
is: Q8IXW6
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_ecbcef8c_6202_48da_9cc7_22eac802b13a
has only substance units: false
name: ST3GAL1
initial amount: NaN
is: Q11201
is: SBO:0000252
type: Species
boundary condition: true
constant: false
is encoded by: hsa:6482
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_6765b210_597f_4cd0_a619_1e653ec0a21d
is encoded by: hsa:23236
initial amount: NaN
name: PLCB1
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false

metaM nad c
is: HMDB00902
is: SBO:0000247
has only substance units: false
is: CHEBI:57540
type: Species
is: C00003
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide
is: http://identifiers.org/pubchem.compound/3305

metaR NAGA2ly
modifier: MODEL1310110053#
name: N-acetylgalactosaminidase, alpha-
is version of: http://identifiers.org/ec-code/3.2.1.49
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110053#
is: SBO:0000176
is described by: ECO:0000000

metaR CYTK7
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110053#
product: MODEL1310110053#
name: cytidylate kinase (CMP,UTP)
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true
is: SBO:0000176

metaM g2m8mpdol U r
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C1845H3040N20O720P20 CHARGE: -20
is: CHEBI:59093
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247

metaM arachdcrn x
type: Species
is: CHEBI:57368
is: HMDB06523
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
name: C20:4 carnitine
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false

metaM o2 e
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
type: Species
name: O2
constant: false
has only substance units: false
is: HMDB01377
boundary condition: false
is: SBO:0000247
is: CHEBI:15379
is: C00007
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_45153b1a_28ec_4e8e_81f4_64b6780687b4
initial amount: NaN
has only substance units: false
is: SBO:0000297
has part: A8DPS7
is encoded by: hsa:5050
is encoded by: hsa:5049
constant: false
boundary condition: true
initial concentration: NaN
type: Species
name: PAFAH1B2:PAFAH1B3
has part: Q15102

http://identifiers.org/biomodels.db/MODEL1310110053#_617237b7_3a52_4649_b1d9_c7e38ec59fbf
is: SBO:0000252
is: P48735
is encoded by: hsa:3418
name: IDH2
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_5d2621e0_e9a6_41bc_8c86_35afd83e176d
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:27034
has only substance units: false
initial concentration: NaN
constant: false
is: Q6ZWP6
name: ACAD8

metaR FERO
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110053#
product: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
name: ferroxidase
reversible: false
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:

metaR r0009
modifier: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.6.1.1
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
reactant: MODEL1310110053#
fast: false

metaM dha e
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16016
initial amount: NaN
is: HMDB01882
name: glycerone
constant: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
has only substance units: false

metaM thbpt c
type: Species
is: SBO:0000247
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
boundary condition: false
constant: false
name: 5,6,7,8-tetrahydrobiopterin
initial concentration: 1.0
is: CHEBI:15372
has only substance units: false
initial amount: NaN
is: HMDB00027

metaR EHGLATm
fast: false
product: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000176
modifier: MODEL1310110053#
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
kinetic law: MODEL1310110053#
is described by: ECO:0000212
reversible: false
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.6.1.1
type: Reaction

metaM m8mpdol U r
initial amount: NaN
notes: FORMULA: C1725H2840N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1
boundary condition: false
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
constant: false
is: SBO:0000247
is: CHEBI:59093
initial concentration: 1.0
has only substance units: false

metaR r2356
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reversible: true
type: Reaction
is described by: ECO:0000000

metaM dcacoa m
name: Decanoyl-CoA (n-C10:0CoA)
type: Species
boundary condition: false
is: HMDB06404
initial amount: NaN
is: C05274
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:61430

metaR r1618
type: Reaction
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
product: MODEL1310110053#
is: SBO:0000185
fast: false

metaM udpacgal l
boundary condition: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: CHEBI:57847
constant: false
is: HMDB00304
name: UDP-N-acetyl-D-galactosamine(2-)
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_da696914_d568_4cfc_b9dd_ff84a5c0189f
initial amount: NaN
name: _AI761708_1_m
type: Species
constant: false
has only substance units: false
is encoded by: hsa:AI761708
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR HMGLm
modifier: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
reversible: false
is described by: ECO:0000134
name: hydroxymethylglutaryl-CoA lyase
fast: false
type: Reaction
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/4.1.3.4

metaR r2142
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110053#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110053#
is: SBO:0000185
reactant: MODEL1310110053#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_c5351e71_7913_4129_bd0c_69cb3a2b063e
has only substance units: false
is encoded by: hsa:2882
constant: false
is: Q96SL4
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
name: GPX7

http://identifiers.org/biomodels.db/MODEL1310110053#_aacb8b8d_d138_4753_86f2_6c1f59a41947
boundary condition: true
name: _BG035985_1_c
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:BG035985
constant: false

metaM idp c
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:58280
name: IDP(3-)
is: HMDB03335
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0

metaM Lcystin e
name: L-cystine
initial concentration: 1.0
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
has only substance units: false
is: SBO:0000247
is: HMDB00192
is: CHEBI:16283
constant: false
type: Species
initial amount: NaN
boundary condition: false

metaR CYTDtm
reactant: MODEL1310110053#
is: SBO:0000185
fast: false
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000269
name: cytidine facilated transport in mitochondria
type: Reaction
reversible: true
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT

metaR r2364
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
product: MODEL1310110053#
type: Reaction
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#

metaM pchol hs r
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
initial amount: NaN
name: Phosphatidylcholine
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16110
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_f8f4cda7_5d8e_499e_b3b8_397763b47158
is: Q5FWE9
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
name: ACOT12
boundary condition: true
is encoded by: hsa:134526

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

metaM nrpphr e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
name: Norepinephrine
is: SBO:0000247
type: Species
is: HMDB00216
constant: false
has only substance units: false
is: CHEBI:33569
initial amount: NaN

metaR r2141
reversible: true
fast: false
modifier: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110053#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185

metaR FUMSO4tm
kinetic law: MODEL1310110053#
type: Reaction
is: SBO:0000185
product: MODEL1310110053#
name: Fumarate:sulfate antiport, mitochondrial
fast: false
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
modifier: MODEL1310110053#
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_a21fcdf0_04db_465f_8008_5adf43600045
initial amount: NaN
name: _AI971036_1_m
is encoded by: hsa:AI971036
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species

metaR r1052
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
type: Reaction
product: MODEL1310110053#
is described by: ECO:0000000
name: Vesicular transport
reversible: false
reactant: MODEL1310110053#
is: SBO:0000185
kinetic law: MODEL1310110053#

metaM dpcoa e
name: Dephospho-CoA
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
constant: false
type: Species
is: HMDB01373
is: SBO:0000247
is: CHEBI:57328
initial amount: NaN
is: C00882

metaR r2363
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110053#
type: Reaction
fast: false
reversible: true
product: MODEL1310110053#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110053#

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_b13fb4fd_bde1_4047_a05d_258737790a72
type: Species
initial amount: NaN
name: ACAD9
boundary condition: true
is encoded by: hsa:28976
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q9H845
has only substance units: false

metaM 4h2oglt m
name: 4-hydroxy-2-oxoglutarate(2-)
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
is: CHEBI:17742
boundary condition: false
is: HMDB02070
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
type: Species

metaR r2140
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110053#
reversible: true
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_50fcbf07_100e_45aa_8a67_3c128b945c91
constant: false
is: SBO:0000252
type: Species
name: _AV727634_1_c
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:AV727634
boundary condition: true

metaM crn r
initial amount: NaN
is: HMDB00062
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: CHEBI:16347
has only substance units: false
boundary condition: false
name: (R)-carnitine
type: Species
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_d86f01ec_ba40_4e20_ab08_dcd168afc9aa
name: NME1:NME2
type: Species
is encoded by: hsa:4830
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000297

metaR CDIPTr
reversible: true
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
name: phosphatidylinositol synthase (Homo sapiens)
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.8.11

metaM malttr e
name: maltotriose
boundary condition: false
initial concentration: 1.0
is: C01835
is: HMDB01262
type: Species
constant: false
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
is: SBO:0000247
is: CHEBI:27931
has only substance units: false
initial amount: NaN

metaM accoa n
constant: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
name: acetyl-CoA(4-)
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB01206
is: CHEBI:57288

metaM CE2839 e
is: http://identifiers.org/pubchem.compound/5041
is: C01936
name: maltodecaose
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_711f191f_5d48_4f58_8cfa_70b4a403d757
initial concentration: NaN
boundary condition: true
name: COX6C
constant: false
type: Species
is encoded by: hsa:1345
has only substance units: false
initial amount: NaN
is: P09669
is: SBO:0000252

metaM xyl D e
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15936
name: aldehydo-D-xylose
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1

metaR r2362
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110053#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110053#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_ac97a9f1_65ad_4459_88e6_323624a9c404
type: Species
initial amount: NaN
is encoded by: hsa:114805
is: SBO:0000252
name: GALNT13
constant: false
initial concentration: NaN
is: Q8IUC8
boundary condition: true
has only substance units: false

metaR DCYTt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
name: deoxycytidine transport via diffusion
reactant: MODEL1310110053#
fast: false
product: MODEL1310110053#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110053#

metaR r1051
product: MODEL1310110053#
name: Vesicular transport
type: Reaction
reversible: true
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_c1431ee9_333b_486f_b29c_f0679837de37
is encoded by: hsa:2954
initial concentration: NaN
is: SBO:0000252
name: GSTZ1
type: Species
has only substance units: false
boundary condition: true
is: O43708
initial amount: NaN
constant: false

metaM Lcystin c
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
has only substance units: false
is: SBO:0000247
is: HMDB00192
is: CHEBI:16283
boundary condition: false
name: L-cystine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_7398aaae_b867_4efe_b016_a32523ed50e4
name: HK1
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:3098
is: P78542

metaR NADtpu
reactant: MODEL1310110053#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
name: NAD transporter, peroxisome
kinetic law: MODEL1310110053#
reversible: false
fast: false
type: Reaction
product: MODEL1310110053#

metaR B3GALT5g
modifier: MODEL1310110053#
product: MODEL1310110053#
fast: false
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: Beta-1,3-galactosyltransferase 5
type: Reaction
is: SBO:0000176
reactant: MODEL1310110053#

metaR C226CRNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
fast: false
is described by: ECO:0000000
product: MODEL1310110053#
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
name: C226 transport into the mitochondria
type: Reaction
is: SBO:0000185
reversible: false

metaM nrpphr c
boundary condition: false
is: CHEBI:33569
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00216
has only substance units: false
constant: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
name: Norepinephrine
initial concentration: 1.0

metaR THYMDtm
name: thymd transport
fast: false
type: Reaction
kinetic law: MODEL1310110053#
reversible: true
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:TDV
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110053#
modifier: MODEL1310110053#

metaM accoa m
is: C00024
has only substance units: false
name: Acetyl-CoA
is: CHEBI:57288
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species
is: HMDB01206
constant: false

metaR INSTt2r
fast: false
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
modifier: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
name: inositol transport in via proton symport
product: MODEL1310110053#
is described by: ECO:0000269
is: SBO:0000185
reversible: true

metaM HC02208 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:27696
name: prostaglandin-d1
has only substance units: false

metaR DNDPt23m
is described by: ECO:0000269
product: MODEL1310110053#
fast: false
reversible: false
reactant: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
name: dTDP transport via dGTP antiport
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#

metaR RE1447N
is described by: ECO:0000000
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110053#
fast: false
name: RE1447
reactant: MODEL1310110053#
type: Reaction

metaM adp c
has only substance units: false
type: Species
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3310
name: ADP
is: C00008
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16761
is: HMDB01341

metaR DOLPMT2 Uer
is: SBO:0000176
reactant: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
kinetic law: MODEL1310110053#
reversible: false
fast: false

metaR PROt2r
product: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reversible: true
is described by: ECO:0000304
is: SBO:0000185
name: L-proline reversible transport via proton symport
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_eccfc670_558a_425f_9172_5596e3ae4351
name: AKR1C4
is encoded by: hsa:1109
initial amount: NaN
constant: false
is: P17516
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_aa778fda_1152_4f4a_b5db_14626670464b
is: G3V0F6
is encoded by: hsa:8525
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
name: DGKZ
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_7e748028_8794_4acd_97d1_e295706146f0
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:2582
boundary condition: true
type: Species
name: GALE
initial concentration: NaN
is: Q38G75

metaM CE1926 e
is: HMDB00127
initial amount: NaN
has only substance units: false
name: gama-carboxyethyl-hydroxychroman
is: CHEBI:15748
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
boundary condition: false
is: SBO:0000247

metaR r2361
reactant: MODEL1310110053#
reversible: true
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110053#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110053#
type: Reaction
is: SBO:0000185

metaR r1050
reactant: MODEL1310110053#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110053#
name: Vesicular transport
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
is described by: ECO:0000000

metaM ivcoa m
initial amount: NaN
name: Isovaleryl-CoA
has only substance units: false
initial concentration: 1.0
is: HMDB01113
constant: false
is: CHEBI:57345
type: Species
is: SBO:0000247
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_1280b29a_4137_4e9d_8a12_52afad551ada
name: NDUFA10
constant: false
is: O95299
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:4705
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_0567faa7_056b_4970_b5bb_eba123cd7cdd
constant: false
initial amount: NaN
name: SLC7A8
is: Q86U05
type: Species
is encoded by: hsa:23428
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM arachdcrn r
name: C20:4 carnitine
initial amount: NaN
is: SBO:0000247
is: CHEBI:57368
initial concentration: 1.0
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
constant: false
type: Species
has only substance units: false
boundary condition: false
is: HMDB06523

metaR MALtm
kinetic law: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
is described by: ECO:0000269
modifier: MODEL1310110053#
name: malate transport, mitochondrial
is: SBO:0000185
type: Reaction
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
reversible: true

metaM mmcoa S m
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
boundary condition: false
initial amount: NaN
is: CHEBI:57327
name: (S)-methylmalonyl-CoA(5-)
is: SBO:0000247
has only substance units: false
is: HMDB02310
initial concentration: 1.0
type: Species
constant: false

metaM dolglcp U c
constant: false
is: CHEBI:15812
type: Species
has only substance units: false
boundary condition: false
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
initial amount: NaN
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
is: SBO:0000247
initial concentration: 1.0

metaM cholcoa r
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
constant: false
boundary condition: false
is: CHEBI:57373
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB01374
name: choloyl-CoA(4-)

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaM 7thf e
initial concentration: 1.0
is: HMDB06559
constant: false
initial amount: NaN
boundary condition: false
name: heptaglutamyl folate (THF)
is: SBO:0000247
notes: FORMULA: C49H57N13O24 CHARGE: -8
has only substance units: false
type: Species

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_1e99554d_a069_4f9e_9483_f1a6e6ccc279
boundary condition: true
is encoded by: hsa:4708
is: H7C5B8
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: NDUFB2
initial concentration: NaN
is: SBO:0000252

metaM HC01118 r
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: presqualene diphosphate(3-)
is: CHEBI:57310
boundary condition: false
constant: false
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428

metaR SUCCtp
name: succinate transporter, peroxisome
is: SBO:0000185
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000000
reactant: MODEL1310110053#

metaM o2 m
has only substance units: false
is: CHEBI:15379
is: HMDB01377
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
name: O2
boundary condition: false
is: SBO:0000247
is: C00007
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_08f20b3d_48c7_4d58_8cc1_b755b17b7705
name: OCRL
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:4952

metaM chol m
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial amount: NaN
constant: false
is: CHEBI:15354
is: HMDB00097
boundary condition: false
has only substance units: false
name: choline
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR r2360
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110053#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110053#

metaR S3TASE3ly
reversible: true
product: MODEL1310110053#
is: SBO:0000176
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
name: N-acetylglucosamine-3-sulfatase, lysosomal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_c078b282_3a23_42ba_8b20_fc56acc5c16f
is encoded by: hsa:56848
type: Species
is: SBO:0000252
name: SPHK2
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q9NRA0

metaM thf c
type: Species
initial amount: NaN
is: C00101
is: SBO:0000247
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: HMDB01846
initial concentration: 1.0
name: 5,6,7,8-Tetrahydrofolate
is: CHEBI:57453
constant: false
has only substance units: false
boundary condition: false

metaM HC02208 e
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
constant: false
type: Species
is: CHEBI:27696
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: prostaglandin-d1
has only substance units: false
initial amount: NaN

metaR LTC4CP
fast: false
product: MODEL1310110053#
name: Leukotriene C4 carboxypeptidase
reactant: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110053#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ

metaM crn m
has only substance units: false
is: CHEBI:16347
is: HMDB00062
initial amount: NaN
type: Species
constant: false
is: C00318
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
name: L-Carnitine

metaM ksi pre33 g
type: Species
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 33
initial amount: NaN
is: SBO:0000247
is: C00130
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00175

metaR FAOXC16080m
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110053#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
name: Beta oxidation of long chain fatty acid

metaM chol n
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
type: Species
is: SBO:0000247
is: CHEBI:15354
boundary condition: false
initial amount: NaN
constant: false
name: choline
is: HMDB00097

http://identifiers.org/biomodels.db/MODEL1310110053#_7696524a_d14e_45b6_9421_f8cc0c41ac72
is encoded by: hsa:285973
boundary condition: true
name: ATG9B
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: Q674R7
constant: false
is: SBO:0000252

metaR GLNS
type: Reaction
kinetic law: MODEL1310110053#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/4.1.1.15
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
name: glutamine synthetase
product: MODEL1310110053#
is: SBO:0000176
reactant: MODEL1310110053#
fast: false

metaM arach e
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
initial amount: NaN
name: arachidate
is: SBO:0000247
is: CHEBI:32360
type: Species
constant: false
boundary condition: false
is: HMDB02212
has only substance units: false
initial concentration: 1.0

metaM glx m
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
name: glyoxylate
initial concentration: 1.0
is: HMDB00119
type: Species
is: CHEBI:36655

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_70cf2875_bfe9_4fde_89e7_11c3415d2e7f
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
name: CA1
has only substance units: false
constant: false
is encoded by: hsa:759
is: P00915

http://identifiers.org/biomodels.db/MODEL1310110053#_7d13955c_7e56_440e_9971_536d3e5f1e7a
name: OGDH
is: SBO:0000252
boundary condition: true
is: Q02218
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:4967

metaR GLNtm
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
fast: false
name: L-glutamine transport via electroneutral transporter
reversible: false
is: SBO:0000185
reactant: MODEL1310110053#
product: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction

metaM bilirub c
name: bilirubin(2-)
is: SBO:0000247
type: Species
constant: false
is: CHEBI:57977
boundary condition: false
is: HMDB00054
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial amount: NaN

metaM idp e
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
name: IDP(3-)
is: CHEBI:58280
is: HMDB03335
boundary condition: false
constant: false
is: SBO:0000247
type: Species
has only substance units: false

metaM gthrd e
constant: false
is: CHEBI:57925
name: glutathionate(1-)
is: HMDB00125
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_57389029_1b48_49b7_8f26_6105275229d8
is encoded by: hsa:2990
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
name: GUSB
is: P08236
constant: false
boundary condition: true
initial concentration: NaN

metaM ksi pre31 g
name: keratan sulfate I biosynthesis, precursor 31
has only substance units: false
initial amount: NaN
is: CHEBI:58053
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: C00130
is: HMDB00175
type: Species
notes: FORMULA: C227H363N16O189S9X CHARGE: -10

metaM itacon m
is: HMDB02092
type: Species
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:17240
is: SBO:0000247
boundary condition: false
name: itaconate(2-)

metaM galside hs g
is: CHEBI:12947
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
constant: false
has only substance units: false
name: D-galactosyl-N-acylsphingosine
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0

metaR r1966
type: Reaction
reversible: false
fast: false
modifier: MODEL1310110053#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#

metaR LACZe
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase
reactant: MODEL1310110053#
name: b-galactosidase, extracellular
type: Reaction
is: SBO:0000176
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.2.1.108
fast: false
reversible: false
product: MODEL1310110053#

metaM Tn antigen g
type: Species
name: Tn antigen
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H14NO5X CHARGE: 0
is: C04383
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_0d5a8995_d597_4e47_8cb2_77e0e1409bc4
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:117248
type: Species
has only substance units: false
is: Q8N3T1
initial amount: NaN
name: GALNTL2

metaM arachdcrn m
is: SBO:0000247
is: CHEBI:57387
has only substance units: false
constant: false
name: C20:4 carnitine
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB01322
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_e88e2c17_35e4_45e9_9f2f_35f8bd07f6c1
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:AA177072
name: _AA177072_1_c
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_f853d7c2_7928_4184_b930_a641c4f38286
is encoded by: hsa:6575
name: SLC20A2
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: B2RBR4
constant: false
type: Species

metaR ILEtec
reactant: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
name: L-isoleucine transport via diffusion (extracellular to cytosol)
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reversible: true
product: MODEL1310110053#

metaR r0236
is version of: http://identifiers.org/ec-code/3.5.1.6
is: SBO:0000176
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
kinetic law: MODEL1310110053#
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000000

metaR CYSTSERex
notes: GENE_ASSOCIATION: (6519.1 and 11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:SAB see PMID 14770310
reactant: MODEL1310110053#
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
name: L-cystine/glycine exchanger (cystine in)
type: Reaction
product: MODEL1310110053#
fast: false
is described by: ECO:0000269
is: SBO:0000185
reversible: false

metaM mlthf m
is: CHEBI:15636
type: Species
initial concentration: 1.0
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
has only substance units: false
initial amount: NaN
is: HMDB01533
is: C00143
boundary condition: false
is: SBO:0000247
name: 5,10-Methylenetetrahydrofolate
constant: false

metaM 56dura c
is: CHEBI:15901
has only substance units: false
name: 5,6-dihydrouracil
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
is: HMDB00076
constant: false
is: SBO:0000247
boundary condition: false

metaM thf e
initial concentration: 1.0
is: HMDB01846
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
is: SBO:0000247
is: CHEBI:57453
constant: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101

metaR H2O2t
kinetic law: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
name: hydrogen peroxide transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110053#
fast: false

metaM dpcoa c
has only substance units: false
is: C00882
is: SBO:0000247
constant: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
type: Species
is: HMDB01373
initial amount: NaN
is: CHEBI:57328
initial concentration: 1.0
name: Dephospho-CoA
boundary condition: false

metaR DCK1n
type: Reaction
reversible: true
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
name: Deoxycytidine kinase, nuclear (ATP)
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
product: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.74

metaM arach c
initial amount: NaN
is: CHEBI:32360
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB02212
name: arachidate
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102

http://identifiers.org/biomodels.db/MODEL1310110053#_94cb1a24_91cf_4caa_86f2_fcb0ea780ec3
initial concentration: NaN
constant: false
name: ETNK2
has only substance units: false
boundary condition: true
is: Q9NVF9
initial amount: NaN
type: Species
is encoded by: hsa:55224
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_88e410d2_5166_4bca_89dc_f9909bee919c
initial concentration: NaN
constant: false
initial amount: NaN
name: ST3GAL2
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:6483
is: SBO:0000252
is: Q16842

metaR BHBtm
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
type: Reaction
product: MODEL1310110053#
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
reversible: true
kinetic law: MODEL1310110053#
fast: false
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110053#_2024ae21_d9be_4772_a015_6c82e5a1f8ab
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaR r2037
type: Reaction
product: MODEL1310110053#
is: SBO:0000185
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110053#
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR AG13T13g
fast: false
product: MODEL1310110053#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110053#
reversible: false
is described by: ECO:0000000
type: Reaction

metaR S6T8g
is: SBO:0000176
kinetic law: MODEL1310110053#
type: Reaction
reversible: false
reactant: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110053#
fast: false
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaR r1630
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110053#
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_c632a3a6_b1b1_4a39_984e_bc126c30fc2c
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4514
name: COX3
constant: false
is: P00414
boundary condition: true

metaR CGLYt3 2
name: Cys-Gly transport in via proton symport
reversible: false
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
is described by: ECO:0000304
fast: false
modifier: MODEL1310110053#
product: MODEL1310110053#
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000185
type: Reaction

metaR GGH 10FTHF7GLUe
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
reversible: false
is described by: ECO:0000000
fast: false
modifier: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000176
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.4.19.9

metaM gthrd c
name: Reduced glutathione
is: CHEBI:57925
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
initial amount: NaN
is: HMDB00125
boundary condition: false
constant: false
is: C00051

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_f772483c_f27d_4eab_9fc6_a832c71f7efe
has only substance units: false
is: Q9BRC7
type: Species
name: PLCD4
is encoded by: hsa:84812
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_1854e614_f489_4a5c_b8db_f4d13b384d83
initial concentration: NaN
is: P16260
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:8034
name: SLC25A16
constant: false

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaM lnlccoa r
initial concentration: 1.0
constant: false
name: linoleic coenzyme A
is: http://identifiers.org/pubchem.compound/5462164
type: Species
boundary condition: false
is: HMDB01064
has only substance units: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: SBO:0000247
initial amount: NaN

metaM dhap e
is: HMDB01473
name: glycerone phosphate(2-)
type: Species
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:57642
initial concentration: 1.0
boundary condition: false

metaR UDPACGALtl
name: udpacgal intracellular transport
reactant: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
type: Reaction
kinetic law: MODEL1310110053#
is: SBO:0000185
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_df10bd31_45f3_4132_87d7_d403eed0f628
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is: Q9BV79
initial concentration: NaN
type: Species
is encoded by: hsa:51102
name: MECR

metaM C05280 m
has only substance units: false
name: cis,cis-3,6-Dodecadienoyl-CoA
is: HMDB03952
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
initial concentration: 1.0
is: CHEBI:28002
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
boundary condition: false

metaR PNTOte
product: MODEL1310110053#
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of (R)-Pantothenate
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_77ff2a46_dcb1_44c0_a349_d888208c5d49
constant: false
initial concentration: NaN
is encoded by: hsa:64077
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
name: LHPP
is: Q9H008

metaM chol r
boundary condition: false
is: CHEBI:15354
is: SBO:0000247
name: choline
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
initial concentration: 1.0
is: HMDB00097
initial amount: NaN
has only substance units: false
type: Species

metaM o2 r
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:15379
has only substance units: false
is: HMDB01377
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
name: O2
type: Species
initial amount: NaN
is: C00007

metaR SR5AR2r
reversible: false
reactant: MODEL1310110053#
modifier: MODEL1310110053#
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
type: Reaction
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.3.99.5
fast: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6715.1) or (6716.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 2 AUTHORS: PMID:14643063 NOTES:see PMID: 14643063 there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ
product: MODEL1310110053#
is: SBO:0000176

metaM cholcoa x
boundary condition: false
is: CHEBI:57373
name: choloyl-CoA(4-)
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB01374
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794

metaR TAURCHAe
product: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
name: exit of taurine from the enterocytes
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14992263 NOTES:taurine is an osmolyte that aids in osmoregulation. Reactive oxygen species (ROS) and eicosanoids activate tyrosine-kinase cascade, resulting in activation of volume sensitive taurine channel. Further ROS causes membrane permeabilization that results in taruine loss.
is described by: ECO:0000134
fast: false
reversible: false
reactant: MODEL1310110053#
is: SBO:0000185

metaM dpcoa m
type: Species
is: HMDB01373
name: 3'-dephospho-CoA(2-)
constant: false
is: CHEBI:57328
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM HC01403 m
is: SBO:0000247
is: CHEBI:28325
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
has only substance units: false
initial amount: NaN
name: (S)-Hydroxydecanoyl-CoA
boundary condition: false

metaM datp c
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: HMDB01532
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
is: C00131
type: Species
is: CHEBI:61404
initial amount: NaN
boundary condition: false
name: dATP

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaM HC00591 c
is: CHEBI:16769
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
name: 2-oxoglutaramate
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940

metaR r1631
reversible: true
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_65922454_f8a8_432f_b01e_2c1c733af81d
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: Q99519
is encoded by: hsa:4758
type: Species
name: NEU1

metaR r0853
reversible: false
name: Facilitated diffusion
reactant: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
type: Reaction
kinetic law: MODEL1310110053#

metaR r1744
modifier: MODEL1310110053#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
product: MODEL1310110053#
is: SBO:0000185

metaR r0913
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110053#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110053#
reversible: true

metaR r0129
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.1.40
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
is described by: ECO:0000000
fast: false
modifier: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000176
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4

metaM hgentis c
name: homogentisate
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00130
is: CHEBI:16169
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544

http://identifiers.org/biomodels.db/MODEL1310110053#_a2443231_6d09_4ae5_8073_3c19a318bde6
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is: Q02218
is encoded by: hsa:4967
initial concentration: NaN
name: OGDH

metaM CE2422 m
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
type: Species
is: CHEBI:28387
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
is: HMDB11123
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
initial concentration: 1.0
boundary condition: false

metaM CE4876 r
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
is: HMDB01509
is: CHEBI:57460
name: delta12-Prostaglandin J2
initial amount: NaN
has only substance units: false

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

metaR FADtru
product: MODEL1310110053#
name: FAD transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110053#
type: Reaction
reversible: false
kinetic law: MODEL1310110053#

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaR r0579
type: Reaction
reversible: true
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is version of: http://identifiers.org/ec-code/1.13.11.19
is described by: ECO:0000000
reactant: MODEL1310110053#
product: MODEL1310110053#
fast: false
is: SBO:0000176

metaR r0651
is version of: http://identifiers.org/ec-code/1.5.1.2
reactant: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
reversible: true
modifier: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
product: MODEL1310110053#
fast: false
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is: SBO:0000176

metaM HC01602 c
name: 10-Formyltetrahydrofolate
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:57454
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: SBO:0000247
is: C00234

http://identifiers.org/biomodels.db/MODEL1310110053#_b238f39f_6700_4b5a_9bea_6f37471fd6e6
has only substance units: false
constant: false
type: Species
is encoded by: hsa:622
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: BDH1

http://identifiers.org/biomodels.db/MODEL1310110053#_4deb2106_ed81_4725_8c2f_683c0c916c71
is encoded by: hsa:7084
initial concentration: NaN
initial amount: NaN
name: TK2
type: Species
is: SBO:0000252
has only substance units: false
is: O00142
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_1b219dde_b767_48ce_a93c_8d0cbbd53492
has only substance units: false
is: Q7Z725
is encoded by: hsa:6569
constant: false
boundary condition: true
name: SLC34A1
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252

metaR r0791
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110053#
type: Reaction
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107

http://identifiers.org/biomodels.db/MODEL1310110053#_5db6e333_1695_4bc0_87f7_90b3a6f680b1
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:8560
is: O15121
name: DEGS1

http://identifiers.org/biomodels.db/MODEL1310110053#_f8413411_00c3_4b7a_9434_3f9dc6bdbd73
is encoded by: hsa:AI620219
constant: false
has only substance units: false
initial concentration: NaN
name: _AI620219_1_m
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species

metaM bilirub e
initial amount: NaN
is: HMDB00054
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
name: bilirubin(2-)
is: CHEBI:57977
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_eaf89be6_287e_47d1_974a_7adad6920777
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q6FHI7
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:762
name: CA4

metaR r2437
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
product: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110053#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_4af6cc33_4dbf_4aa0_a37e_8376544f40b0
constant: false
name: _R33828_1_c
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:R33828
initial concentration: NaN

metaR ATP2ter
reactant: MODEL1310110053#
name: AMP/ATP transporter, endoplasmic reticulum
kinetic law: MODEL1310110053#
reversible: true
is described by: ECO:0000000
product: MODEL1310110053#
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaM xyl D l
name: aldehydo-D-xylose
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: CHEBI:15936

metaR r0650
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is: SBO:0000176
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/4.1.1.36
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
product: MODEL1310110053#
fast: false
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#

metaR r0911
name: Facilitated diffusion
is: SBO:0000185
kinetic law: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110053#
product: MODEL1310110053#
reversible: true

metaR UAG4E
is version of: http://identifiers.org/ec-code/5.1.3.2
reversible: true
modifier: MODEL1310110053#
name: UDP-N-acetylglucosamine 4-epimerase
fast: false
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000176
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_a6a3dc5f_1a14_45bd_860e_ddbb0804ed76
is: D9HTE9
name: SLC25A1
boundary condition: true
is encoded by: hsa:6576
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial amount: NaN

metaM crn c
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
type: Species
boundary condition: false
name: L-Carnitine
has only substance units: false
is: CHEBI:16347
constant: false
initial concentration: 1.0
is: HMDB00062
is: C00318
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_e8cc42c8_0132_4e06_9d50_4a534eef23ee
boundary condition: true
initial concentration: NaN
is encoded by: hsa:50484
constant: false
has only substance units: false
is: SBO:0000252
name: RRM2B
initial amount: NaN
is: Q7LG56
type: Species

metaR r1747
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110053#
name: Y+LAT2 Utilized transport
product: MODEL1310110053#
modifier: MODEL1310110053#
reversible: false

metaR AG13T7g
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110053#
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
kinetic law: MODEL1310110053#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110053#

metaR NTD4
notes: GENE_ASSOCIATION: (51251.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:11795870 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
product: MODEL1310110053#
name: 5'-nucleotidase (CMP)
reversible: false
kinetic law: MODEL1310110053#
is described by: ECO:0000254
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.5
modifier: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
is: SBO:0000176

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaR RIBt
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: ribose transport via diffusion
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reactant: MODEL1310110053#
fast: false
product: MODEL1310110053#

metaR PSP L
reversible: false
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.1.3.3
type: Reaction
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
kinetic law: MODEL1310110053#
name: phosphoserine phosphatase (L-serine)
is: SBO:0000176
fast: false
modifier: MODEL1310110053#
is described by: ECO:0000269
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_f34a54ce_5a06_4b21_8cdd_23137d045f06
is: SBO:0000252
is: D3DX95
type: Species
is encoded by: hsa:1103
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: CHAT
has only substance units: false
constant: false

metaR TCHOLAtx
type: Reaction
name: bile acid intracellular transport
product: MODEL1310110053#
reversible: true
kinetic law: MODEL1310110053#
is described by: ECO:0000000
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110053#_ba7c9d44_1547_4551_b9ef_14b758afa024
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4833
is: O00746
type: Species
name: NME4
boundary condition: true
constant: false

metaM HC02210 c
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:34939
name: prostaglandin-d3
has only substance units: false
constant: false

metaM Tn antigen l
type: Species
has only substance units: false
is: C04383
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
name: Tn antigen
initial concentration: 1.0
notes: FORMULA: C8H14NO5X CHARGE: 0

metaR 4NPHSFte
reversible: true
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
is: SBO:0000185
fast: false
name: xenobiotic transport
product: MODEL1310110053#

metaM adp m
is: C00008
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: CHEBI:456216
name: ADP
is: HMDB01341
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/3310

metaR IDPtn
name: IDP nuclear transport
type: Reaction
product: MODEL1310110053#
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
reversible: true
is described by: ECO:0000000

metaM ncam c
is: C00153
name: Nicotinamide
boundary condition: false
notes: FORMULA: C6H6N2O CHARGE: 0
is: HMDB01406
has only substance units: false
is: CHEBI:0
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_88d7e9ce_1c2d_4cb3_8bfd_b04d2ceab4fd
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: _AI926493_1_m
has only substance units: false
type: Species
is encoded by: hsa:AI926493

metaM hdca c
is: CHEBI:7896
has only substance units: false
constant: false
name: palmitate
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00220
initial amount: NaN
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249

metaR r1549
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110053#
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true
type: Reaction

metaM lnlccoa m
has only substance units: false
name: linoleic coenzyme A
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5462164
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: HMDB01064
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_bcaffe63_7501_441c_b066_c7e41e6a07de
name: COX6B1
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P14854
is encoded by: hsa:1340
type: Species
has only substance units: false
is: SBO:0000252

metaR MMMm
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.99.2
reversible: true
modifier: MODEL1310110053#
name: methylmalonyl-CoA mutase
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
product: MODEL1310110053#
fast: false

metaR HSD3B12r
type: Reaction
reactant: MODEL1310110053#
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.1.1.145
is described by: ECO:0000134
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
is: SBO:0000176
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (3284.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12832414 NOTES:kinetic studies done with recombinant human cDNA transfected into baculovirus
reversible: false

metaM CE2433 m
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041
initial concentration: 1.0
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
has only substance units: false
initial amount: NaN
constant: false
is: C01936
is: SBO:0000247

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR r0917
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
kinetic law: MODEL1310110053#
reversible: true
reactant: MODEL1310110053#
fast: false
is: SBO:0000185
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR r2439
name: Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP), TCDB:2.A.53.2.2
product: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12759755 NOTES:
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000000

metaR CYTK9n
type: Reaction
name: cytidylate kinase (CMP,dCTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_e17321d7_757b_4288_ba02_2dd71e8630fa
constant: false
has only substance units: false
is encoded by: hsa:883
name: CCBL1
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q16773

metaR VALTAm
is described by: ECO:0000269
reactant: MODEL1310110053#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110053#
product: MODEL1310110053#
modifier: MODEL1310110053#
name: valine transaminase, mitochondiral

metaM pchol hs m
constant: false
name: Phosphatidylcholine
initial amount: NaN
is: CHEBI:16110
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
is: SBO:0000247
boundary condition: false

metaR SO4t4 2
is: SBO:0000185
fast: false
reactant: MODEL1310110053#
is described by: ECO:0000269
kinetic law: MODEL1310110053#
type: Reaction
name: sulfate transport via sodium symport
reversible: true
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
modifier: MODEL1310110053#

metaM hs l
initial concentration: 1.0
is: CHEBI:28815
type: Species
boundary condition: false
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
initial amount: NaN
constant: false
is: SBO:0000247
name: heparan sulfate, free chain
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_acbe311e_a3c0_45a2_a054_5ce23b8f8a3f
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is: P31040
constant: false
is encoded by: hsa:6389
name: SDHA
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_3b400440_ef27_4585_9679_6666e3236a6a
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: P40926
is: SBO:0000252
type: Species
is encoded by: hsa:4191
name: MDH2

metaM acac m
name: acetoacetate
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00060
is: CHEBI:13705
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM hs deg5 l
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
constant: false
is: CHEBI:17895
name: heparan sulfate, degradation product 5
is: HMDB00158
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM adp n
boundary condition: false
constant: false
type: Species
name: ADP(3-)
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB01341
has only substance units: false
is: CHEBI:456216
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_712b8772_c22d_44f3_8b87_018df8afa986
name: PPA1
is: Q15181
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:5464
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_4e4311a1_14b7_482c_bf90_3b352abdf277
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
is: P49902
has only substance units: false
initial concentration: NaN
name: NT5C2
is encoded by: hsa:22978

http://identifiers.org/biomodels.db/MODEL1310110053#_8faa84ca_60ef_40a4_b77e_63a6c7346aa6
constant: false
is: F5H6D0
type: Species
is encoded by: hsa:7841
boundary condition: true
has only substance units: false
name: MOGS
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR r1548
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
reversible: true

metaM q10h2 m
constant: false
is: http://identifiers.org/pubchem.compound/6504740
initial concentration: 1.0
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: HMDB13111
type: Species
initial amount: NaN
boundary condition: false
name: Ubiquinol-10
is: SBO:0000247
has only substance units: false

metaR r0796
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
reversible: true
reactant: MODEL1310110053#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
modifier: MODEL1310110053#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
kinetic law: MODEL1310110053#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_dec98f57_de5e_4cd8_ba46_a0dea6f67946
name: ALDH3A2
boundary condition: true
constant: false
type: Species
is: P51648
initial concentration: NaN
is encoded by: hsa:224
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM txa2 r
name: thromboxane A2(1-)
type: Species
is: HMDB01452
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:57445
constant: false

metaR CITL
modifier: MODEL1310110053#
name: Citrate lyase
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
reversible: false
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
fast: false
product: MODEL1310110053#

metaM thf m
type: Species
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
has only substance units: false
name: 5,6,7,8-Tetrahydrofolate
is: CHEBI:57453
boundary condition: false
initial concentration: 1.0
constant: false
is: C00101
is: HMDB01846
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_ca0f2a9e_14bf_4c00_955d_e049e61f0aa1
initial amount: NaN
type: Species
is encoded by: hsa:25769
name: SLC24A2
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q9UI40
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_268b5cda_d3a5_4161_b420_0847d6f74c3c
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q99643
is encoded by: hsa:6391
has only substance units: false
boundary condition: true
initial amount: NaN
name: SDHC
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_ab4a2cd3_ce74_4afb_b543_0a2f54f1a765
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
name: SLC27A1
is encoded by: hsa:376497
is: SBO:0000252
initial concentration: NaN

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_afdc7b34_9702_4414_a7fa_310e0449bd3b
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:231
name: AKR1B1
is: P15121
type: Species
constant: false
initial amount: NaN

metaM hdca e
name: Hexadecanoate (n-C16:0)
constant: false
is: C00249
has only substance units: false
is: SBO:0000247
is: HMDB00220
type: Species
boundary condition: false
notes: FORMULA: C16H31O2 CHARGE: -1
initial concentration: 1.0
initial amount: NaN
is: CHEBI:0

http://identifiers.org/biomodels.db/MODEL1310110053#_b5385e46_2674_4ab5_b0a2_b4b4d88f94ef
boundary condition: true
is: SBO:0000252
name: DGKZ
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: B7Z6M3
is encoded by: hsa:8525
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_b6bd0481_5b72_45a0_94d0_1803ef0afce5
has only substance units: false
constant: false
is: B2RB13
initial concentration: NaN
is encoded by: hsa:23305
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: ACSL6
type: Species

metaM ncam e
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C6H6N2O CHARGE: 0
is: C00153
is: CHEBI:0
initial amount: NaN
is: HMDB01406
initial concentration: 1.0
boundary condition: false
name: Nicotinamide
constant: false

metaM dhap c
is: http://identifiers.org/pubchem.compound/3411
is: C00111
is: HMDB01473
name: Dihydroxyacetone phosphate
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:57642

http://identifiers.org/biomodels.db/MODEL1310110053#_9c7f323e_3200_46dd_8430_6b267f593ae2
constant: false
is: SBO:0000252
initial concentration: NaN
name: RDH14
is encoded by: hsa:57665
is: Q9HBH5
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true

metaR r0915
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110053#
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
reactant: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000185

metaR r1547
type: Reaction
reactant: MODEL1310110053#
reversible: true
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
kinetic law: MODEL1310110053#

metaM ptth c
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
name: pantetheine
initial concentration: 1.0
has only substance units: false
is: CHEBI:16753
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
type: Species
is: HMDB03426

metaR r1557
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110053#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110053#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_85ea2410_f235_4e1e_bf0f_810405dca4eb
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:29925
name: GMPPB

http://identifiers.org/biomodels.db/MODEL1310110053#_e7ea24e6_2313_407e_81c3_7cd83f971b53
constant: false
initial concentration: NaN
is: Q92947
name: GCDH
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:2639

http://identifiers.org/biomodels.db/MODEL1310110053#_cb211301_d8e0_401a_8981_6b611f67502b
has only substance units: false
type: Species
name: DGKG
initial concentration: NaN
is encoded by: hsa:1608
is: P49619
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

metaR NTD9
name: 5'-nucleotidase (GMP)
is: SBO:0000176
reversible: false
is described by: ECO:0000134
type: Reaction
product: MODEL1310110053#
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31

metaM pail5p hs n
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:57795
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
type: Species

metaR r0644
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
is: SBO:0000176
reversible: true

metaR S2TASE2ly
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.13
kinetic law: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
reactant: MODEL1310110053#
name: iduronate-2-sulfatase, lysosomal
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110053#_de6fcfe5_600f_443e_bf94_9d60c3d796cf
is: SBO:0000252
name: ACAD9
initial concentration: NaN
initial amount: NaN
is: Q9H845
is encoded by: hsa:28976
type: Species
constant: false
boundary condition: true
has only substance units: false

metaR r1627
is: SBO:0000185
kinetic law: MODEL1310110053#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110053#
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_115be5ca_464f_4030_9882_2fa7aa9aad9b
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:84701
name: COX4I2
boundary condition: true
is: Q96KJ9

metaR LEUtec
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
name: L-leucine transport via diffusion (extracellular to cytosol)
reversible: true
product: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_a668bcd7_8065_40b4_87ec_d3d7c8c2d438
is: Q5JT09
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
name: UCK1
is encoded by: hsa:83549
has only substance units: false
constant: false

metaR VALtec
kinetic law: MODEL1310110053#
name: L-valine transport via diffusion (extracellular to cytosol)
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reactant: MODEL1310110053#
modifier: MODEL1310110053#
fast: false
product: MODEL1310110053#

metaM prostge2 e
has only substance units: false
type: Species
is: SBO:0000247
constant: false
is: HMDB01220
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:606564
name: prostaglandin E2(1-)

metaM ksi pre36 g
initial concentration: 1.0
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 36
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
has only substance units: false
constant: false

metaR RE1573M
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110053#
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1573
type: Reaction
product: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
is version of: http://identifiers.org/ec-code/5.3.3.8
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_d578c204_4d74_419a_956a_57a6c77ba40c
initial concentration: NaN
is encoded by: hsa:5091
type: Species
constant: false
boundary condition: true
is: SBO:0000252
name: PC
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_523ebeec_fa52_4559_aec1_1369c1002498
initial concentration: NaN
is: P34949
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:4351
constant: false
initial amount: NaN
name: MPI
is: SBO:0000252

metaR ALASm
reversible: false
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
reactant: MODEL1310110053#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.37
name: 5-aminolevulinate synthase
type: Reaction
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.3.1.29
product: MODEL1310110053#
kinetic law: MODEL1310110053#

metaM dadp n
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57667
is: SBO:0000247
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
constant: false
has only substance units: false
name: dADP(3-)
boundary condition: false
is: HMDB01508

http://identifiers.org/biomodels.db/MODEL1310110053#_acfcee22_1602_4d9e_934d_789153524a1a
is: B4DK61
is encoded by: hsa:51
boundary condition: true
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
name: ACOX1
has only substance units: false
is: SBO:0000252

metaR r1626
kinetic law: MODEL1310110053#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110053#
reactant: MODEL1310110053#
modifier: MODEL1310110053#
reversible: true
is: SBO:0000185

metaM arachdcrn c
name: C20:4 carnitine
is: CHEBI:57387
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
constant: false
initial amount: NaN
is: HMDB01322
boundary condition: false
type: Species

metaR GASNASE2ly
reversible: false
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/3.5.1.26
is: SBO:0000176
is described by: ECO:0000000
name: glycosylasparaginase, lysosomal
product: MODEL1310110053#
fast: false

metaM HC01162 c
initial concentration: 1.0
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
is: CHEBI:58376
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691

metaR HSAT2ly
product: MODEL1310110053#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
name: heparan-glucosaminide N-acetyltransferase, lysosomal
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110053#

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaM nad x
is: http://identifiers.org/pubchem.compound/3305
boundary condition: false
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:57540
has only substance units: false
name: Nicotinamide adenine dinucleotide
is: C00003
initial amount: NaN
is: HMDB00902

http://identifiers.org/biomodels.db/MODEL1310110053#_68d9cc77_dd69_407e_b61b_05eb52703889
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:217
name: ALDH2
initial concentration: NaN
is: P05091
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_52f0c569_2969_4652_9adf_8c7bcbbd21be
is encoded by: hsa:257202
is: SBO:0000252
initial amount: NaN
name: GPX6
boundary condition: true
initial concentration: NaN
type: Species
is: P59796
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_c66a7169_a746_43d6_9a67_ca2d6a4cb5b2
constant: false
is: Q86VV3
is encoded by: hsa:953
is: SBO:0000252
name: ENTPD1
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR ACACt2
reversible: true
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
fast: false
type: Reaction
modifier: MODEL1310110053#
name: acetoacetate transport via proton symport
product: MODEL1310110053#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_81e760f9_06ad_444e_99db_7d9b3bd8246a
initial amount: NaN
is: Q9UBM7
constant: false
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
name: DHCR7
is encoded by: hsa:1717
is: SBO:0000252

metaR r1625
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000000

metaR r0787
is version of: http://identifiers.org/ec-code/1.1.1.1
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
reactant: MODEL1310110053#
product: MODEL1310110053#
modifier: MODEL1310110053#

metaR r0584
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110053#
is: SBO:0000176
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
type: Reaction
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
modifier: MODEL1310110053#
reversible: true
is described by: ECO:0000000

metaM dadp m
is: CHEBI:57667
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: HMDB01508
type: Species
name: dADP(3-)

metaR NAHCO3 HCLt
is: SBO:0000185
fast: false
name: bicarbonate transport (HCl/NaHCO3 exchange)
kinetic law: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#
product: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
reactant: MODEL1310110053#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110053#_d4584d8c_725c_47e9_8bf7_fd00643f7926
is: A6NFM2
is encoded by: hsa:5831
constant: false
boundary condition: true
type: Species
name: PYCR1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR M4MPDOL Uter
name: m4mpdol flippase
is: SBO:0000185
reactant: MODEL1310110053#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000000
reversible: false

metaM leuktrB4 e
name: leukotriene B4(1-)
is: SBO:0000247
is: HMDB01085
constant: false
initial amount: NaN
is: CHEBI:57461
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR RE2659R
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reactant: MODEL1310110053#
name: RE2659
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110053#
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_258c2760_4aa3_4371_8b41_948e916acc7c
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:18
initial amount: NaN
type: Species
constant: false
name: ABAT

metaR HSAT1ly
name: heparan-glucosaminide N-acetyltransferase, lysosomal
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
product: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
fast: false
is: SBO:0000185

metaM 2kmb c
name: 2-keto-4-methylthiobutyrate
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C5H7O3S CHARGE: -1
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16723
has only substance units: false
type: Species
is: HMDB01553

metaR O2ter
product: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true
fast: false
name: O2 transport, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaR THYMt
reactant: MODEL1310110053#
fast: false
product: MODEL1310110053#
reversible: true
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
name: thymine reversible transport via facilated diffusion
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
type: Reaction

metaR RE3011R
kinetic law: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
is: SBO:0000176
reversible: true
name: RE3011
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9799565,PMID:9862787 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_70dc6ad5_48cb_4fe3_96d2_28e9499ec00f
boundary condition: true
is: SBO:0000252
name: NDUFA2
is encoded by: hsa:4695
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: O43678

metaR r0647
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
type: Reaction
name: Spontaneous reaction
product: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110053#
reversible: true

metaM prostge2 c
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB01220
name: prostaglandin E2(1-)
is: CHEBI:606564
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_209ac993_d38e_4dac_9a3d_29962c877021
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:2880
constant: false
is: O75715
name: GPX5
type: Species
initial concentration: NaN

metaR r1624
is described by: ECO:0000000
reactant: MODEL1310110053#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110053#
product: MODEL1310110053#
modifier: MODEL1310110053#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r1556
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110053#
kinetic law: MODEL1310110053#

metaR r0788
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is: SBO:0000176
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
type: Reaction
reactant: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
reversible: true

metaM sph1p c
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57939
has only substance units: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
boundary condition: false
is: HMDB01383
type: Species
constant: false
initial amount: NaN
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate

http://identifiers.org/biomodels.db/MODEL1310110053#_957de9d6_7c16_49a7_a5b4_ae82e6fb5a59
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
name: ACAA1
is encoded by: hsa:30
is: Q96CA6
boundary condition: true
has only substance units: false

metaM hs deg4 l
initial concentration: 1.0
constant: false
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:16126
name: heparan sulfate, degradation product 4
type: Species
is: SBO:0000247

metaM o2 x
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
is: SBO:0000247
name: O2
initial concentration: 1.0
is: CHEBI:15379
is: C00007
type: Species
boundary condition: false

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR TCHOLAte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
kinetic law: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000185
reversible: true
name: bile acid intracellular transport
is described by: ECO:0000000

metaR GGH 7DHFe
reversible: false
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110053#
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
name: Gamma-glutamyl hydrolase (7DHF), extracellular

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaM 4nphsf e
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
initial concentration: 1.0
name: 4-Nitrophenyl sulfate
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:35422
is: HMDB06492

http://identifiers.org/biomodels.db/MODEL1310110053#_3bf0d3e5_a1c0_4957_bdd1_5b46a2cfa0eb
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: SLC16A10
has only substance units: false
is encoded by: hsa:117247
is: SBO:0000252
is: Q8TF71
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_aeaddfed_c845_4d42_a918_d246b25ae575
type: Species
is: SBO:0000252
is encoded by: hsa:2799
boundary condition: true
initial concentration: NaN
is: Q7Z3X3
initial amount: NaN
has only substance units: false
name: GNS
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_f69b91ba_2271_4538_b593_376b9ee7c363
initial amount: NaN
name: _AF116616_1_m
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AF116616
constant: false

metaR GULNDer
name: gulonate dehydrogenase, endoplasmic reticulum
kinetic law: MODEL1310110053#
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110053#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.19 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
product: MODEL1310110053#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110053#_6be4231c_d6b7_46ea_a8ba_3fa77c045020
is: B4DX94
is encoded by: hsa:5238
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: PGM3
constant: false

metaM mescon m
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
name: Mesaconate
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
is: CHEBI:36986
constant: false
initial concentration: 1.0
is: HMDB00749

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name: B3GALNT1
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:8706
constant: false
is: B3KTQ4
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_25b29b95_4893_4d29_9f0b_889546142fd5
is: SBO:0000252
is encoded by: hsa:641372
has only substance units: false
constant: false
initial concentration: NaN
is: Q3I5F7
type: Species
name: ACOT6
boundary condition: true
initial amount: NaN

metaM trp L e
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
type: Species
initial concentration: 1.0
boundary condition: false
name: L-tryptophan
is: CHEBI:16828
constant: false
has only substance units: false
is: HMDB00929

metaR r0789
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
kinetic law: MODEL1310110053#
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110053#
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
product: MODEL1310110053#

metaR r1623
reversible: true
fast: false
modifier: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM acac c
constant: false
is: HMDB00060
name: acetoacetate
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: CHEBI:13705
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_ddbb7c09_6430_4fc6_9bd7_f67406c0b938
has only substance units: false
is: P40394
type: Species
is encoded by: hsa:131
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
name: ADH7

metaR CSm
reversible: false
is: SBO:0000176
is described by: ECO:0000134
product: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (1431.1) or (1431.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.7 Confidence Level: 0 AUTHORS: PMID:16006620,PMID:9933076 NOTES:IF old EC number (4.1.3.7) is obsolete -- transferred to 2.3.3.1 NCD. Biochemical
fast: false
name: citrate synthase
is version of: http://identifiers.org/ec-code/2.3.3.1
type: Reaction
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#

metaR r1553
type: Reaction
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110053#

metaM ksi pre17 g
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 17
constant: false
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
initial amount: NaN
is: CHEBI:28067
type: Species

metaM mi1p D c
has only substance units: false
boundary condition: false
is: CHEBI:58433
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: 1D-myo-inositol 1-phosphate(2-)
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
type: Species
is: HMDB02985

metaR G14T3g
is described by: ECO:0000000
product: MODEL1310110053#
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110053#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
kinetic law: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90

http://identifiers.org/biomodels.db/MODEL1310110053#_c32cda0e_3ef8_4579_a306_4d5e623a1709
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:124
is: SBO:0000297
constant: false
initial amount: NaN
name: ADH1A:ADH1B
has part: P07327

metaR SR5ARr
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110053#
fast: false
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.3.99.5
type: Reaction
reactant: MODEL1310110053#
modifier: MODEL1310110053#
reversible: false

metaM leuktrB4 c
name: leukotriene B4(1-)
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB01085
has only substance units: false
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial amount: NaN
is: CHEBI:57461
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_59a2febe_336d_4a0e_bc1b_ee23bff68b9b
is encoded by: hsa:AA021081
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
name: _AA021081_1_r
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR SACCD3m
fast: false
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.5.1.8
kinetic law: MODEL1310110053#
reversible: false
product: MODEL1310110053#
type: Reaction
name: saccharopine dehydrogenase (NADP, L-lysine forming), mitochondrial
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.8 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
modifier: MODEL1310110053#
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110053#_bd8a6457_21e0_42e6_a26e_8fac30dc469b
name: _PRO1933_1_m
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:PRO1933
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR G14T17g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
type: Reaction
reactant: MODEL1310110053#
fast: false

metaM q10h2 c
has only substance units: false
type: Species
initial amount: NaN
is: HMDB13111
name: Ubiquinol-10
boundary condition: false
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/6504740
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: SBO:0000247

metaR CYTD
reactant: MODEL1310110053#
name: cytidine deaminase
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.5.4.5
reversible: false
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
product: MODEL1310110053#
fast: false
is described by: ECO:0000254
type: Reaction
is: SBO:0000176
modifier: MODEL1310110053#

metaM tre e
is: C01083
is: SBO:0000247
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:16551
initial concentration: 1.0
is: HMDB00975
name: Trehalose

metaM arab L c
name: L-arabinose
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:30849
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0
is: HMDB00646

metaM 4nphsf c
is: CHEBI:35422
constant: false
initial concentration: 1.0
type: Species
is: HMDB06492
has only substance units: false
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
name: 4-Nitrophenyl sulfate
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_8ae76883_44d7_4a1b_9bfc_c3db154011a7
is encoded by: hsa:9334
initial concentration: NaN
has only substance units: false
name: B4GALT5
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is: O43286
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_166994ba_04d4_4f6b_97dc_22709278fd06
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: PNPO
is: SBO:0000252
boundary condition: true
is: Q9NVS9
is encoded by: hsa:55163

metaR GLCter
is: SBO:0000185
reversible: true
name: glucose transport, endoplasmic reticulum
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
fast: false
is described by: ECO:0000000
reactant: MODEL1310110053#
type: Reaction
product: MODEL1310110053#

metaR r0641
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
product: MODEL1310110053#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.4
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
is: SBO:0000176

metaR r1622
is described by: ECO:0000000
kinetic law: MODEL1310110053#
reversible: true
product: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110053#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false

metaM 44mzym r
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB01286
constant: false
is: CHEBI:18364
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: 14-demethyllanosterol
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108

http://identifiers.org/biomodels.db/MODEL1310110053#_2e3751c0_42ea_41d6_a580_22f7ced889fa
has only substance units: false
is: P32321
boundary condition: true
initial concentration: NaN
name: DCTD
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:1635

http://identifiers.org/biomodels.db/MODEL1310110053#_e232e7cc_e2b0_4ecc_b796_2914798cf55b
is: Q9Y2C5
initial concentration: NaN
boundary condition: true
constant: false
type: Species
name: SLC17A4
has only substance units: false
is encoded by: hsa:10050
initial amount: NaN
is: SBO:0000252

metaR r1554
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110053#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_ab049c71_f031_439b_8622_5cb8ad490033
name: PDHX
is: SBO:0000252
constant: false
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: O00330
is encoded by: hsa:8050

metaM lnlncacoa c
is: SBO:0000247
is: CHEBI:51985
initial amount: NaN
constant: false
is: HMDB06290
initial concentration: 1.0
type: Species
has only substance units: false
name: alpha-Linolenoyl-CoA
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_0924754e_d69c_4c00_9e27_0b6e89799bba
name: ALDH3B2
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is: P48448
is encoded by: hsa:222
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_dbe63bb0_4476_48c5_919a_defacb9eaf45
boundary condition: true
is: SBO:0000252
name: SGPL1
type: Species
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: O95470
is encoded by: hsa:8879

metaR NDP7g
kinetic law: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
type: Reaction
is described by: ECO:0000269
product: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.6.1.6
reversible: false
modifier: MODEL1310110053#
name: nucleoside-diphosphatase (UDP), Golgi apparatus

metaR EX leugly LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylglycine
type: Reaction

metaM HC00361 c
name: sedoheptulose 1,7-bisphosphate(4-)
boundary condition: false
is: CHEBI:58335
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
constant: false
is: SBO:0000247
initial concentration: 1.0

metaM ppcoa m
is: SBO:0000247
is: HMDB01275
type: Species
initial amount: NaN
name: Propanoyl-CoA
initial concentration: 1.0
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: C00100
is: CHEBI:57392
has only substance units: false
constant: false
boundary condition: false

metaR PAFH
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000269
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (5051.1) or (5049.1 and 5050.1) or (5049.1 and 5050.1 and 5048.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:7669037,PMID:8028668,PMID:8955149 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.1.47
fast: false
modifier: MODEL1310110053#
is: SBO:0000176
name: Platelet-activating factor acetylhydrolase
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_2f08599a_a562_4555_858f_717de40ea132
is: SBO:0000252
has only substance units: false
is encoded by: hsa:NOS2A
initial amount: NaN
boundary condition: true
name: _NOS2A_1_c
initial concentration: NaN
type: Species
constant: false

metaR RPE
kinetic law: MODEL1310110053#
name: ribulose 5-phosphate 3-epimerase
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/5.1.3.1
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110053#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110053#
fast: false

metaR r0642
reversible: true
reactant: MODEL1310110053#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110053#
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
is: SBO:0000176
fast: false

metaM m5masnB2 g
boundary condition: false
is: CHEBI:58469
is: SBO:0000247
initial concentration: 1.0
type: Species
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
constant: false
is: HMDB01313
has only substance units: false
notes: FORMULA: C52H87N2O40X CHARGE: 0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_10e143a3_19fd_48f5_bbac_dc27e73ec7fe
constant: false
is: SBO:0000252
is encoded by: hsa:7296
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
name: TXNRD1
boundary condition: true

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaM trp L c
name: L-tryptophan
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16828
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
constant: false
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00929

http://identifiers.org/biomodels.db/MODEL1310110053#_0ae437f0_1d98_4427_9cc7_7badb7879827
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
name: ENPP1
is: P22413
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:5167

metaR r1621
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
is: SBO:0000185
modifier: MODEL1310110053#

metaR CO2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
is: SBO:0000185
name: CO2 transporter via diffusion
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#
fast: false

metaM hs deg21 l
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: CHEBI:16126
boundary condition: false
notes: FORMULA: C37H55NO38S2 CHARGE: -4
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: SBO:0000247
initial concentration: 1.0

metaR RE1233C
reversible: true
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.6.1.64
kinetic law: MODEL1310110053#
product: MODEL1310110053#
fast: false
name: RE1233
type: Reaction
reactant: MODEL1310110053#
modifier: MODEL1310110053#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110053#_2aa7d113_91b1_403c_92c7_0cf88618e523
boundary condition: true
has part: P23434
is encoded by: hsa:275
name: DLD:GCSH:GLDC:AMT
type: Species
has part: P48728
constant: false
is encoded by: hsa:2653
is encoded by: hsa:2731
initial concentration: NaN
has part: P23378
initial amount: NaN
is: SBO:0000297
has only substance units: false

metaR HSD3A1r
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is version of: http://identifiers.org/ec-code/1.1.1.225
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000269
modifier: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_8ed6ba67_0991_4737_ba15_c31181f5eac9
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
name: MTAP
is encoded by: hsa:4507
is: Q13126

http://identifiers.org/biomodels.db/MODEL1310110053#_1cda0bd5_4f8f_4e2c_859d_904089efb6bb
constant: false
boundary condition: true
is: SBO:0000252
name: _AL050025_1_c
type: Species
has only substance units: false
is encoded by: hsa:AL050025
initial amount: NaN
initial concentration: NaN

metaR r2038
is: SBO:0000185
kinetic law: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
product: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110053#
reactant: MODEL1310110053#
fast: false

metaM acac e
is: SBO:0000247
is: HMDB00060
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: acetoacetate
is: CHEBI:13705
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_062a6f96_19f9_4d38_b3a7_909042a5f01f
is: Q9ULC5
type: Species
is: SBO:0000252
is encoded by: hsa:51703
name: ACSL5
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_ca6adbbf_1870_418f_8197_cf64afb69d7f
is encoded by: hsa:10558
is: SBO:0000252
type: Species
has only substance units: false
is: O15269
constant: false
boundary condition: true
initial concentration: NaN
name: SPTLC1
initial amount: NaN

metaR r1551
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110053#
reversible: true
kinetic law: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM q10h2 e
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6504740
type: Species
is: HMDB13111
has only substance units: false
initial amount: NaN
boundary condition: false
name: Ubiquinol-10
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
constant: false

metaR R group phosphotase 1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110053#
reversible: false
name: R group phosphotase 1
type: Reaction
product: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
is: SBO:0000176

metaM pyr m
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:15361
constant: false
initial concentration: 1.0
is: HMDB00243
has only substance units: false
is: http://identifiers.org/pubchem.compound/3324
is: C00022
name: pyruvate
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022

metaM occoa m
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB01070
name: Octanoyl-CoA (n-C8:0CoA)
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
initial amount: NaN
constant: false
is: C01944
is: CHEBI:57386
initial concentration: 1.0
has only substance units: false

metaR r0587
is: SBO:0000176
type: Reaction
product: MODEL1310110053#
reversible: true
fast: false
reactant: MODEL1310110053#
is described by: ECO:0000000
modifier: MODEL1310110053#
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:

metaR r0643
reversible: true
fast: false
product: MODEL1310110053#
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
reactant: MODEL1310110053#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_b650d914_f34f_482d_a3a4_be04cd653747
boundary condition: true
is: E9PCP2
is encoded by: hsa:1375
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
name: CPT1B

metaR KYNATESYN
kinetic law: MODEL1310110053#
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110053#
reversible: false

metaR r1552
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110053#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r1620
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
is: SBO:0000185
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM chito2pdol U c
is: CHEBI:12427
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human uterine homolog
boundary condition: false
notes: FORMULA: C1185H1940N20O170P20 CHARGE: -20
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_75b5b02a_6f7c_4d20_a0be_5b31d7560f9b
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: COX7A2L
is: Q6FGA0
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:9167

http://identifiers.org/biomodels.db/MODEL1310110053#_7cb6b754_b92b_4500_96d7_0a45ee6cb434
boundary condition: true
is: P53794
name: SLC5A3
is encoded by: hsa:6526
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaR R group phosphotase 2
product: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
fast: false
kinetic law: MODEL1310110053#
reversible: false
is: SBO:0000176
name: R group phosphotase 2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:

metaR ADKd
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: true
product: MODEL1310110053#
modifier: MODEL1310110053#
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
is described by: ECO:0000269
name: adenylate kinase (d form)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_9ef12f61_a93e_4126_9d68_731a57e4a88e
is encoded by: hsa:3242
boundary condition: true
is: SBO:0000252
type: Species
name: HPD
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: B3KQ63
constant: false

metaR RE0935E
modifier: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.1
kinetic law: MODEL1310110053#
name: RE0935
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_400c3ff3_6931_4812_8851_91646572f205
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
type: Species
name: GMPPA
is encoded by: hsa:29926
boundary condition: true

metaR Q10H2e
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
name: transport of ubiquinol into lymph
fast: false
is described by: ECO:0000134
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true
product: MODEL1310110053#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110053#_5b84af09_80b8_4eaa_83eb_aef27d9c358f
name: SLC38A1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:81539
is: Q9H2H9
constant: false

metaM dgtp n
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: C00286
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
name: dGTP
is: SBO:0000247
is: HMDB01440
is: CHEBI:16497
boundary condition: false

metaR PRPNCOAHYDm
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110053#
name: Propenoyl-CoA hydrolase (m)
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/4.2.1.18
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay

http://identifiers.org/biomodels.db/MODEL1310110053#_2ae5debc_3994_48e9_84b9_e647dc4165e9
constant: false
is: P19440
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
name: GGT1
initial concentration: NaN
is encoded by: hsa:2678

http://identifiers.org/biomodels.db/MODEL1310110053#_18833a41_94cd_4dd3_8efa_bedbbb387289
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:48
is: P21399
is: SBO:0000252
name: ACO1

metaM his L m
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15971
is: HMDB00177
boundary condition: false
has only substance units: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
name: L-histidine
constant: false
is: SBO:0000247

metaR DHPM2
kinetic law: MODEL1310110053#
name: dihydropyrimidinase (dihydrothymine)
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 2 AUTHORS: NOTES:Also acts on dihydrothymine and hydantoin. Found not specific evidence in PubMed, but Dihydropyrimidinase is supposed to be in cytosol and catalyze this reaction. Old information
is described by: ECO:0000000
reactant: MODEL1310110053#
reversible: false
product: MODEL1310110053#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_e8542e80_6c01_4df8_a0cf_8e02f7b40c8e
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is: O75610
is encoded by: hsa:10637
has only substance units: false
name: LEFTY1
constant: false
initial amount: NaN

metaM 6dhf e
is: HMDB06563
initial concentration: 1.0
type: Species
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
is: SBO:0000247
has only substance units: false
name: hexaglutamyl folate (DHF)
boundary condition: false
constant: false
initial amount: NaN

metaM adp x
is: SBO:0000247
type: Species
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
name: ADP(3-)
is: CHEBI:456216
is: HMDB01341
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008

metaR CORE2GTg
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.102
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
reactant: MODEL1310110053#
type: Reaction
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110053#_2a112a6f_2c8a_4168_ada6_7357d1ce5c92
has only substance units: false
is: B3KXK1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:115019
constant: false
boundary condition: true
type: Species
name: SLC26A9

metaM gthox c
initial amount: NaN
is: C00127
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: CHEBI:58297
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB03337
name: Oxidized glutathione
constant: false
is: SBO:0000247
boundary condition: false

metaR DCTPtn
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
reversible: true
fast: false
name: dCTP diffusion in nucleus
is described by: ECO:0000000
product: MODEL1310110053#

metaM ascb L c
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00044
has only substance units: false
boundary condition: false
is: CHEBI:38290
name: L-ascorbate
is: SBO:0000247
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074

http://identifiers.org/biomodels.db/MODEL1310110053#_04848e1f_5b0c_4938_a332_f0d4332fd7e7
name: SLC2A3
is encoded by: hsa:6515
is: P11169
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_ffcbaf5e_9ed4_4925_9a5a_2571c430bf6d
name: ST3GAL3
is encoded by: hsa:6487
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species

metaR r0097
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
type: Reaction
name: Acetate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
is: SBO:0000176
reversible: false
reactant: MODEL1310110053#
product: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_4151621c_87ff_4595_b618_4b3a04ee5c98
constant: false
has only substance units: false
is: P20674
type: Species
boundary condition: true
is encoded by: hsa:9377
name: COX5A
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR DOLPH Uer
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reversible: false
reactant: MODEL1310110053#
fast: false
name: Dolichol-phosphate phosphohydrolase, human (uterus)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:

metaM dhap x
initial concentration: 1.0
is: C00111
is: HMDB01473
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:57642
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3411
name: Dihydroxyacetone phosphate

metaR G13MT U
reversible: false
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110053#
is described by: ECO:0000000
reactant: MODEL1310110053#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.132
kinetic law: MODEL1310110053#
name: Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)
fast: false
is: SBO:0000176

metaR CHSTEROLtrc
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
is: SBO:0000185
fast: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
name: transport of cholesterol into the cytosol
type: Reaction

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaM hxan c
boundary condition: false
type: Species
is: HMDB00157
initial concentration: 1.0
constant: false
is: C00262
is: SBO:0000247
has only substance units: false
name: Hypoxanthine
is: CHEBI:17368
initial amount: NaN
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262

metaR ABTti
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000185
name: L-arabinitol transport via passive diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110053#

metaR KHte
fast: false
product: MODEL1310110053#
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true
name: KHte
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR r2369
reactant: MODEL1310110053#
reversible: true
fast: false
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
type: Reaction
product: MODEL1310110053#
is: SBO:0000185
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR PSERT
name: phosphoserine transaminase
reactant: MODEL1310110053#
fast: false
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:
modifier: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.52
product: MODEL1310110053#
type: Reaction

metaM taur c
has only substance units: false
constant: false
initial amount: NaN
name: Taurine
type: Species
initial concentration: 1.0
is: C00245
notes: FORMULA: C2H7NO3S CHARGE: 0
boundary condition: false
is: HMDB00251
is: CHEBI:3544
is: SBO:0000247

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_b5e0d548_5ad9_4d30_826e_08a90b28218b
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
name: LYZL1
is encoded by: hsa:84569
is: SBO:0000252
constant: false
initial amount: NaN
is: Q6UWQ5

metaM g1p c
boundary condition: false
has only substance units: false
initial amount: NaN
is: C00103
type: Species
name: D-Glucose 1-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
is: SBO:0000247
initial concentration: 1.0
is: HMDB01586
is: CHEBI:58601
constant: false

metaR RE1516M
is version of: http://identifiers.org/ec-code/1.3.99.13
product: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reactant: MODEL1310110053#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
modifier: MODEL1310110053#
fast: false
name: RE1516
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_50ec4850_6f4d_43e2_a73a_c81f585bd5a1
is: P05091
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:217
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ALDH2
constant: false

metaR RE1342C
type: Reaction
name: RE1342
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_b7d290b4_06eb_4ffb_9480_b48f983b85f4
boundary condition: true
is encoded by: hsa:6517
type: Species
has only substance units: false
initial amount: NaN
is: P14672
name: SLC2A4
constant: false
is: SBO:0000252
initial concentration: NaN

metaR CYTK11n
name: cytidylate kinase (dCMP,dGTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true

metaR ALAt2r
fast: false
name: L-alanine reversible transport via proton symport
modifier: MODEL1310110053#
reversible: true
reactant: MODEL1310110053#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
kinetic law: MODEL1310110053#
type: Reaction
is: SBO:0000185
product: MODEL1310110053#

metaM ksi pre1 g
type: Species
name: keratan sulfate I biosynthesis, precursor 1
initial amount: NaN
notes: FORMULA: C79H129N5O57X CHARGE: -1
is: C00130
has only substance units: false
boundary condition: false
is: HMDB00175
is: SBO:0000247
is: CHEBI:58053
constant: false
initial concentration: 1.0

metaM galside hs c
type: Species
name: D-galactosyl-N-acylsphingosine
boundary condition: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: CHEBI:12947
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_4661a535_298f_4b3a_86c6_ca12081b3e37
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10400
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: PEMT
constant: false

metaR r0426
modifier: MODEL1310110053#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.34
product: MODEL1310110053#
is described by: ECO:0000000
type: Reaction
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#

metaR DHPM1
product: MODEL1310110053#
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
name: dihydropyrimidinase (5,6-dihydrouracil)
reversible: false
is version of: http://identifiers.org/ec-code/3.5.2.2

metaM ascb L e
type: Species
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
constant: false
is: HMDB00044
is: CHEBI:38290
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
name: L-ascorbate
initial amount: NaN

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaR THYOXt2
reactant: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
kinetic law: MODEL1310110053#
reversible: true
is described by: ECO:0000269
is: SBO:0000185
fast: false
name: T4 transport via facilitated diffusion
modifier: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_47a8a97b_8d07_480b_8de0_2557915a741a
name: CPT2
type: Species
constant: false
boundary condition: true
is encoded by: hsa:1376
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P23786

metaR FADH2tru
fast: false
reversible: false
reactant: MODEL1310110053#
is: SBO:0000185
name: FADH2 transporter, endoplasmic reticulum
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
kinetic law: MODEL1310110053#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_8ad8ca29_36c0_441a_b199_2262c47e09ad
is encoded by: hsa:125
type: Species
has only substance units: false
is: P00325
name: ADH1B
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM pyr c
is: http://identifiers.org/pubchem.compound/3324
is: SBO:0000247
is: CHEBI:15361
name: pyruvate
is: HMDB00243
is: C00022
notes: FORMULA: C3H3O3 CHARGE: -1
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaM HC02179 e
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:34306
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
type: Species
boundary condition: false
initial concentration: 1.0
name: 20-hydroxy-arachidonate

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

metaR G12MT1 U
type: Reaction
reactant: MODEL1310110053#
product: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)

http://identifiers.org/biomodels.db/MODEL1310110053#_b91347ef_8d45_4641_a5de_0854af53a164
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: ACSS1
type: Species
is: Q9NUB1
is encoded by: hsa:84532
has only substance units: false
constant: false
boundary condition: true

metaM hxan e
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00157
name: hypoxanthine
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: CHEBI:17368
boundary condition: false
is: SBO:0000247

metaM txa2 c
type: Species
is: SBO:0000247
boundary condition: false
name: thromboxane A2(1-)
has only substance units: false
is: HMDB01452
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: CHEBI:57445

metaR r0355
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.3
fast: false
type: Reaction
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
product: MODEL1310110053#
modifier: MODEL1310110053#
reversible: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110053#_15700128_3119_4e9d_aecc_4a17efc3503d
boundary condition: true
name: CA13
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:377677
has only substance units: false
initial amount: NaN
is: Q8N1Q1
constant: false

metaR r0425
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:
name: EC:1.1.1.42
modifier: MODEL1310110053#
product: MODEL1310110053#
reversible: true
is version of: http://identifiers.org/ec-code/1.17.1.4
kinetic law: MODEL1310110053#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110053#
is: SBO:0000176
fast: false

metaM c226crn m
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
is: HMDB06510
is: http://identifiers.org/pubchem.compound/127055
type: Species
name: cervonyl carnitine
boundary condition: false

metaR r2367
name: Organic anion transporter 5 Utilized transport
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110053#
fast: false
type: Reaction
kinetic law: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110053#_82711c7a_8918_42e4_9741_b523527ceabf
boundary condition: true
name: _NM_013421_1_m
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:NM 013421
has only substance units: false

metaM idp n
constant: false
is: CHEBI:58280
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB03335
initial concentration: 1.0
has only substance units: false
name: IDP(3-)
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial amount: NaN

metaR TXASr
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.99.5
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
reactant: MODEL1310110053#
product: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
name: Thromboxane-A synthase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110053#_280d00cf_4a8c_4599_b516_3cb4880208ee
type: Species
has only substance units: false
is encoded by: hsa:60482
initial concentration: NaN
is: Q9GZV3
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: SLC5A7

metaR LPS2e
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.3 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:carbonyl and extra H accounted for in R group NJ
product: MODEL1310110053#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#
fast: false
name: lipase, extracellular
is version of: http://identifiers.org/ec-code/3.1.1.3
is: SBO:0000176
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_64b2a53c_b966_42b1_b545_44bdef81e883
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110053#_ecee289c_4ccd_4ab6_8721_2b42945698f4
constant: false
name: CHST1
is: SBO:0000252
type: Species
has only substance units: false
is: O43916
boundary condition: true
is encoded by: hsa:8534
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_1bcc12c7_6639_4b07_812f_be68b651cfcf
name: _HG2846_HT2983_1_c
is encoded by: hsa:HG2846-HT2983
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species

metaM xyl D c
initial concentration: 1.0
name: aldehydo-D-xylose
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:15936
is: SBO:0000247
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1

metaM txa2 e
is: HMDB01452
type: Species
is: CHEBI:57445
name: thromboxane A2(1-)
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198

metaM prostgf2 c
is: CHEBI:57404
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB01139
initial amount: NaN
name: prostaglandin F2alpha(1-)

http://identifiers.org/biomodels.db/MODEL1310110053#_b3a636d2_3a3e_4781_8c19_09a6c1ebb789
is: SBO:0000252
name: AGPAT6
type: Species
is encoded by: hsa:137964
initial amount: NaN
has only substance units: false
constant: false
is: Q86UL3
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_29dfc86b_7e98_409e_baf3_5c90f2d61e61
is encoded by: hsa:2720
has part: Q99519
has only substance units: false
is encoded by: hsa:2588
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4758
has part: P16278
is: SBO:0000297
type: Species
constant: false
has part: P34059
has part: P10619
boundary condition: true
name: GALNS:GLB1:NEU1:CTSA
is encoded by: hsa:5476

metaR FAOXC2051843m
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110053#
is: SBO:0000176
is described by: ECO:0000000
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110053#
reversible: false
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110053#

metaR SO4tl
is: SBO:0000185
reactant: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
kinetic law: MODEL1310110053#
is described by: ECO:0000269
name: Sulfate transport (lysosome)
fast: false

metaM sph1p e
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
is: CHEBI:57939
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
is: HMDB01383
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
has only substance units: false
boundary condition: false
initial amount: NaN

metaR r2368
is described by: ECO:0000000
kinetic law: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110053#
fast: false
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM chol e
initial amount: NaN
is: C00114
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
boundary condition: false
constant: false
is: HMDB00097
name: Choline
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:15354

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

metaR RE1523M
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
modifier: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110053#
name: RE1523
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM hdca r
constant: false
is: SBO:0000247
name: Hexadecanoate (n-C16:0)
initial concentration: 1.0
type: Species
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
boundary condition: false
initial amount: NaN
is: HMDB00220
is: CHEBI:7896
has only substance units: false
is: C00249

http://identifiers.org/biomodels.db/MODEL1310110053#_e53f7ad0_3fee_4e49_a4a6_4afab91bfde3
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: AK5
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:26289

http://identifiers.org/biomodels.db/MODEL1310110053#_50635ae9_94d6_427e_b815_cd28f915d44f
is encoded by: hsa:27068
initial concentration: NaN
name: PPA2
boundary condition: true
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is: F8WDN9
initial amount: NaN

metaM pyr e
is: SBO:0000247
is: CHEBI:15361
is: HMDB00243
name: pyruvate
boundary condition: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
has only substance units: false

metaM HC02179 c
type: Species
name: 20-hydroxy-arachidonate
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial amount: NaN
is: CHEBI:34306
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_9be639ee_93ca_4f42_abe0_c7b0f7afb837
is: SBO:0000252
is: P15291
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:2683
name: B4GALT1
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_c412d3b8_f775_4175_a67b_5e117b45b1da
has only substance units: false
is: O95168
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
boundary condition: true
name: NDUFB4
is: SBO:0000252
is encoded by: hsa:4710

http://identifiers.org/biomodels.db/MODEL1310110053#_7973b08e_0108_43e0_b7cd_4137aa35f936
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is: Q548A7
initial amount: NaN
type: Species
is: SBO:0000252
name: SLC26A6
is encoded by: hsa:65010

http://identifiers.org/biomodels.db/MODEL1310110053#_60eb1009_749b_4a2f_a51b_ee2dca021e6e
name: SGPL1
type: Species
is: O95470
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:8879
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR r2365
reactant: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110053#
kinetic law: MODEL1310110053#
name: Organic anion transporter 5 Utilized transport
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR S6T13g
is described by: ECO:0000000
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110053#
type: Reaction
product: MODEL1310110053#

metaR r0580
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
modifier: MODEL1310110053#
is: SBO:0000176
product: MODEL1310110053#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.7
reactant: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
kinetic law: MODEL1310110053#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_7cdee8da_0965_4aac_b5cd_9b4907fe87a6
initial concentration: NaN
name: DGKD
is: SBO:0000252
is encoded by: hsa:8527
has only substance units: false
is: Q16760
type: Species
boundary condition: true
initial amount: NaN
constant: false

metaR TRIODTHYt2
fast: false
reversible: true
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000185
type: Reaction
product: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is described by: ECO:0000269
name: T3 transport via facilitated diffusion

metaR r1629
kinetic law: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110053#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM CE2432 m
is: C01936
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
has only substance units: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041

metaR r0423
modifier: MODEL1310110053#
product: MODEL1310110053#
reversible: true
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110053#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:

metaM n2m2nm l
boundary condition: false
is: SBO:0000247
has only substance units: false
name: n2m2nmasn (w/o peptide linkage)
notes: FORMULA: C58H97N5O41 CHARGE: 0
initial concentration: 1.0
is: HMDB01356
type: Species
constant: false
is: CHEBI:57312
initial amount: NaN

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaR B3GNT39g
is described by: ECO:0000000
reactant: MODEL1310110053#
product: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
fast: false
modifier: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110053#_6cc0d71d_9363_470f_ae0d_4d9cab84dd67
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: IDH1
is: O75874
boundary condition: true
is encoded by: hsa:3417

metaR ADPtx
type: Reaction
fast: false
is described by: ECO:0000000
name: ADP transporter, peroxisomal
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000185
reversible: true
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ

http://identifiers.org/biomodels.db/MODEL1310110053#_0b73e9a0_d85f_4ed1_906c_a2c761689dac
name: KDSR
initial concentration: NaN
is encoded by: hsa:2531
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: Q06136

metaR RE3565C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reactant: MODEL1310110053#
is: SBO:0000176
kinetic law: MODEL1310110053#
name: RE3565
type: Reaction
product: MODEL1310110053#
fast: false
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_027c9e30_8f39_49aa_b7bf_a610fa24c8a2
has only substance units: false
type: Species
initial concentration: NaN
constant: false
name: SPTLC2
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9517
is: O15270

http://identifiers.org/biomodels.db/MODEL1310110053#_161a6616_cb7b_4686_9701_19ef5ab32d3e
constant: false
is: Q86V21
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
name: AACS
is: SBO:0000252
is encoded by: hsa:65985
has only substance units: false

metaR UDPtl
is: SBO:0000185
reactant: MODEL1310110053#
product: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
is described by: ECO:0000000
type: Reaction
name: udp intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110053#_61de6206_4f12_49c0_b62d_aec913fc3461
type: Species
name: GALK1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2584
is: P51570
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR EX nac LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinate exchange
type: Reaction

metaR EX glyc S LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (S)-Glycerate exchange
type: Reaction

metaM dolmanp U c
type: Species
constant: false
name: Dolichyl phosphate D-mannose, human uterine homolog
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15809

metaR r2366
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false

metaR CHOLATEt
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
is: SBO:0000185
modifier: MODEL1310110053#
is described by: ECO:0000269
reactant: MODEL1310110053#
name: cholate transport via bicarbonate countertransport
reversible: true
product: MODEL1310110053#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_514ec060_0ae1_4208_9c9c_5b8551cf644d
has only substance units: false
boundary condition: true
is encoded by: hsa:4726
is: Q6IBC4
name: NDUFS6
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR r1628
reversible: true
is described by: ECO:0000000
product: MODEL1310110053#
fast: false
is: SBO:0000185
reactant: MODEL1310110053#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR RE3628M
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/5.3.3.8
reactant: MODEL1310110053#
modifier: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reversible: true
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE3628
is described by: ECO:0000000

metaM prostgf2 e
name: prostaglandin F2alpha(1-)
is: CHEBI:57404
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
constant: false
is: HMDB01139
boundary condition: false
has only substance units: false
initial amount: NaN

metaR r0354
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reactant: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110053#

metaR FAOXC161802m
type: Reaction
kinetic law: MODEL1310110053#
reversible: false
name: Beta oxidation fatty acid
modifier: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
is described by: ECO:0000269
reactant: MODEL1310110053#
product: MODEL1310110053#

metaR SPHS1Pte
type: Reaction
product: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: sphingosine-1-phosphate transport
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#

metaM chol c
is: CHEBI:15354
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial amount: NaN
boundary condition: false
is: C00114
has only substance units: false
name: Choline
is: HMDB00097
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaM pmtcoa m
is: HMDB01338
boundary condition: false
name: Palmitoyl-CoA (n-C16:0CoA)
initial concentration: 1.0
is: CHEBI:57379
constant: false
is: SBO:0000247
is: C00154
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154

metaM HC02205 c
name: prostaglandin-b2
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:28099

metaR HPYRR2x
kinetic law: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
is described by: ECO:0000304
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.27
notes: GENE_ASSOCIATION: (3948.1) or (197257.1) or (3945.1) or (160287.1) or (3945.1 and 3939.1) or (92483.1) or (3939.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:14635115,PMID:5635456 NOTES:NCD
reactant: MODEL1310110053#
modifier: MODEL1310110053#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.2.4
fast: false
name: hydroxypyruvate reductase (NADH)

metaR r2195
product: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true

metaR SUCD1m
name: succinate dehydrogenase
reversible: true
modifier: MODEL1310110053#
fast: false
type: Reaction
reactant: MODEL1310110053#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
is: SBO:0000176
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.3.5.1

metaM dolmanp U r
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:15809
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
name: Dolichyl phosphate D-mannose, human uterine homolog

http://identifiers.org/biomodels.db/MODEL1310110053#_647c803e_7cfc_4b41_939f_968c594068c7
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:160851
type: Species
name: DGKH
is: Q86XP1
boundary condition: true
is: SBO:0000252
constant: false

metaR 3MOBt2im
product: MODEL1310110053#
fast: false
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport
is: SBO:0000185
type: Reaction
reversible: false
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
is described by: ECO:0000000
kinetic law: MODEL1310110053#

metaR PPNCL3
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/6.3.2.5
fast: false
is described by: ECO:0000269
reactant: MODEL1310110053#
name: phosphopantothenate-cysteine ligase
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reversible: false
type: Reaction

metaM gdp g
is: HMDB01201
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
initial amount: NaN
name: GDP(3-)
is: CHEBI:58189
has only substance units: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035

http://identifiers.org/biomodels.db/MODEL1310110053#_41a18853_39b6_4d03_8419_035d2990101f
is: P55084
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
name: HADHB
is encoded by: hsa:3032
constant: false
is: SBO:0000252
boundary condition: true

metaR LEUKTRF4t
reactant: MODEL1310110053#
product: MODEL1310110053#
reversible: true
name: leukotriene F4 transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110053#
is: SBO:0000185

metaR UMPK5n
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110053#
name: UMP kinase (dATP),nuclear
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_acce626d_1a00_4c48_b989_7a8732dd241a
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
name: BAAT
constant: false
is encoded by: hsa:570
is: SBO:0000252
is: Q14032
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_a8eb3bf6_96d5_41b3_9733_6abe497e60a2
initial concentration: NaN
name: CYP4F22
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:126410
type: Species
is: SBO:0000252
is: Q6NT55

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

metaM n2m2nmn l
notes: FORMULA: C50H84N4O36 CHARGE: 0
is: HMDB00123
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:15428

metaR r2043
is: SBO:0000185
type: Reaction
modifier: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110053#
fast: false
reversible: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR GLCURter
reversible: false
kinetic law: MODEL1310110053#
name: glucuronate endoplasmic reticular transport
is described by: ECO:0000000
product: MODEL1310110053#
is: SBO:0000185
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
fast: false

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_4e779cd2_8b94_413c_81d2_4daf10b213df
name: UAP1
boundary condition: true
is encoded by: hsa:6675
is: SBO:0000252
type: Species
initial amount: NaN
is: Q16222
has only substance units: false
initial concentration: NaN
constant: false

metaR r2196
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
fast: false
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
is: SBO:0000185

metaR r1914
product: MODEL1310110053#
modifier: MODEL1310110053#
reversible: false
is: SBO:0000185
fast: false
kinetic law: MODEL1310110053#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110053#
name: Y+LAT2 Utilized transport

metaR r0547
product: MODEL1310110053#
is described by: ECO:0000000
reactant: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.1.4
modifier: MODEL1310110053#
name: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5
reversible: true
fast: false
kinetic law: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:

metaR PSSA1 hs
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
product: MODEL1310110053#
name: Phosphatidylserine synthase homo sapiens
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.8.29
fast: false
kinetic law: MODEL1310110053#
type: Reaction
reversible: true
modifier: MODEL1310110053#

metaM hdd2coa m
is: CHEBI:61526
is: C05272
initial concentration: 1.0
initial amount: NaN
is: HMDB03945
boundary condition: false
name: trans-Hexadec-2-enoyl-CoA
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
type: Species
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_f97d03bb_e17d_4db4_bdbc_f66828f4f4aa
is: SBO:0000252
name: SLC22A2
initial amount: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:6582
initial concentration: NaN
boundary condition: true

metaR LNLCt
fast: false
is described by: ECO:0000000
product: MODEL1310110053#
is: SBO:0000185
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: Linoleic acid (n-C18:2) transport in via diffusion

metaR MANtg
product: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: mannose efflux from Golgi apparatus
reversible: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110053#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_087d2540_7cbe_47fe_b4e7_523c3fb2b15e
is: Q9NPB1
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
name: NT5M
has only substance units: false
is encoded by: hsa:56953

http://identifiers.org/biomodels.db/MODEL1310110053#_0a26433e_4a8c_4f59_8f2a_a0e479cd6be6
constant: false
initial concentration: NaN
is: P19404
type: Species
name: NDUFV2
boundary condition: true
has only substance units: false
is encoded by: hsa:4729
initial amount: NaN
is: SBO:0000252

metaM dadp c
is: SBO:0000247
constant: false
is: CHEBI:57667
is: C00206
initial concentration: 1.0
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: HMDB01508
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
name: dADP

metaR r2044
modifier: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110053#
is described by: ECO:0000000
reactant: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
fast: false
reversible: false

metaM hs deg22 l
boundary condition: false
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
initial amount: NaN
is: CHEBI:21338
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C37H56NO35S CHARGE: -3
is: HMDB02704
is: SBO:0000247
type: Species

metaR r2197
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
product: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110053#
modifier: MODEL1310110053#
fast: false

metaR r0885
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.3.1.38
is: SBO:0000185
modifier: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_9ee52b3a_a794_4ced_8cc4_bcaf95d57abc
is: SBO:0000252
constant: false
is: P30084
has only substance units: false
boundary condition: true
initial concentration: NaN
name: ECHS1
type: Species
initial amount: NaN
is encoded by: hsa:1892

metaM HC02205 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
constant: false
has only substance units: false
name: prostaglandin-b2
initial concentration: 1.0
boundary condition: false
is: CHEBI:28099
type: Species
is: SBO:0000247
initial amount: NaN

metaM pect e
name: pectins
notes: FORMULA: C2535H3509O2535 CHARGE: -1
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: HMDB03402
has only substance units: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_53b31797_5c08_4e7c_8217_be30c6ba404a
is: Q6IBE6
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6484
type: Species
initial amount: NaN
is: SBO:0000252
name: ST3GAL4
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_9fa6fb3c_3e2b_4303_8c40_372f574e391a
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: SLC4A4
constant: false
is: A5JJ20
has only substance units: false
is encoded by: hsa:8671

http://identifiers.org/biomodels.db/MODEL1310110053#_e31dca52_6432_4456_8ddf_66686b177dc6
constant: false
boundary condition: true
name: HGD
is: Q93099
has only substance units: false
is encoded by: hsa:3081
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_d24d3730_24b3_4220_a265_999593f41008
initial concentration: NaN
type: Species
is encoded by: hsa:760
name: CA2
constant: false
boundary condition: true
is: SBO:0000252
is: P00918
has only substance units: false
initial amount: NaN

metaM orn m
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H13N2O2 CHARGE: 1
constant: false
type: Species
name: Ornithine
initial concentration: 1.0
is: C01602
is: HMDB00214
is: CHEBI:46912
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_19bfb735_fa94_48a7_9892_caf92e8587bb
constant: false
is: P22392
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4831
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
name: NME2

http://identifiers.org/biomodels.db/MODEL1310110053#_441dfa0f_7570_4377_b66a_95d7aee41604
initial amount: NaN
is: SBO:0000252
is: O14495
is encoded by: hsa:8613
name: PPAP2B
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
type: Species

metaM leugly e
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H16N2O3 CHARGE: 0
name: Leucylglycine
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/97364

http://identifiers.org/biomodels.db/MODEL1310110053#_3905a0e0_faa0_4c60_96bf_d1b844fa225c
constant: false
initial concentration: NaN
is encoded by: hsa:AI222095
is: SBO:0000252
name: _AI222095_1_m
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true

metaR r0549
is version of: http://identifiers.org/ec-code/1.6.5.3
fast: false
product: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.6.99.3
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
type: Reaction
is version of: http://identifiers.org/ec-code/6.1.1.17
is described by: ECO:0000000
modifier: MODEL1310110053#

metaR r2198
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reversible: true
product: MODEL1310110053#
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaR r2045
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110053#
product: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110053#
reversible: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_a5b8e25c_a06f_4f89_99dd_d53b8f31e445
is encoded by: hsa:4830
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: NME1
is: P15531
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_6a101211_55ab_4afd_9b20_b02b99a93fce
name: GNE
is: SBO:0000252
type: Species
is: B7Z428
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:10020
initial amount: NaN

metaR PGISr
fast: false
is version of: http://identifiers.org/ec-code/5.3.99.4
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ
modifier: MODEL1310110053#
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110053#
reversible: true
type: Reaction
kinetic law: MODEL1310110053#
name: Prostaglandin I2 synthase
product: MODEL1310110053#

metaM CE5788 e
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB02710
is: SBO:0000247
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
constant: false
is: CHEBI:27485
has only substance units: false
name: kinetensin 1-7

metaM fmn e
initial concentration: 1.0
is: HMDB01520
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:58210
notes: FORMULA: C17H19N4O9P CHARGE: -2
name: FMN
is: C00061
type: Species
constant: false
boundary condition: false

metaM n2m2nmasn e
initial concentration: 1.0
is: C04946
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
constant: false
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C58H96N5O40X CHARGE: 0
has only substance units: false

metaM oh1 e
is: HMDB01039
initial amount: NaN
has only substance units: false
name: hydroxide ion
type: Species
notes: FORMULA: HO CHARGE: -1
constant: false
initial concentration: 1.0
is: C01328
is: SBO:0000247
boundary condition: false

metaR GULN3D
fast: false
is described by: ECO:0000000
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
product: MODEL1310110053#
name: L-gulonate 3-dehydrogenase
kinetic law: MODEL1310110053#
is: SBO:0000176
type: Reaction
reversible: true

metaM e4hglu m
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
boundary condition: false
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
is: CHEBI:6331
name: erythro-4-hydroxy-L-glutamate(1-)
has only substance units: false
is: HMDB02273
initial amount: NaN

metaR r1912
kinetic law: MODEL1310110053#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110053#
modifier: MODEL1310110053#
reversible: false
product: MODEL1310110053#

metaM pe hs c
initial concentration: 1.0
has only substance units: false
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16038
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_fc5ffce5_30e8_4b63_890c_88257d6536ac
type: Species
boundary condition: true
is encoded by: hsa:124
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is: P07327
name: ADH1A
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_06a94089_be39_4904_8bd4_5e63cf19c3d0
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2678
initial amount: NaN
is: P19440
is: SBO:0000252
type: Species
name: GGT1

metaM strdnc l
is: C16300
is: HMDB06547
type: Species
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205608
is: SBO:0000247
constant: false
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
name: stearidonic acid C18:4, n-3
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_508882a2_f1aa_4d78_8dd3_a56536c4a47b
name: _R51273_1_c
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:R51273
type: Species

metaR G14T5g
is described by: ECO:0000000
fast: false
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
modifier: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_6ded9ec9_76dc_4eb0_b0c3_3900451e6f7d
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:51557
is: Q5TDP6
initial concentration: NaN
name: LGSN

metaR CHSTEROLt2
is described by: ECO:0000000
product: MODEL1310110053#
name: cholesterol intracellular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000185
type: Reaction
reversible: true

metaM arachcoa e
name: arachidyl coenzyme A
is: HMDB04258
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:15527
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_c5a4f5cf_bdf3_493a_9e30_e3006803a832
has only substance units: false
type: Species
is: SBO:0000252
constant: false
name: PRDX3
boundary condition: true
is encoded by: hsa:10935
initial amount: NaN
is: P30048
initial concentration: NaN

metaR r0139
kinetic law: MODEL1310110053#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110053#
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.3.2.2
reversible: true
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
is: SBO:0000176
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5

metaM mmcoa R m
type: Species
initial concentration: 1.0
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
is: HMDB01269
initial amount: NaN
has only substance units: false
is: CHEBI:57326
constant: false
name: (R)-methylmalonyl-CoA(5-)
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_98501787_27aa_4398_a0f7_23f08b733923
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: CDS1
type: Species
is: Q92903
is encoded by: hsa:1040
is: SBO:0000252
has only substance units: false

metaR DOLPGT2 Uer
fast: false
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
is: SBO:0000176
product: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.265
kinetic law: MODEL1310110053#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
modifier: MODEL1310110053#
reversible: false

metaR r1778
reversible: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#

metaR LTD4DP
fast: false
reversible: true
is: SBO:0000176
name: Leukotriene D4 dipeptidase
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
is described by: ECO:0000000
reactant: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#

metaM gdp c
has only substance units: false
is: HMDB01201
is: CHEBI:58189
type: Species
constant: false
name: GDP
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial amount: NaN
is: C00035
is: SBO:0000247

metaR r1641
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110053#
reversible: true
fast: false
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110053#_643c1f55_a722_496d_a616_c27815fdb543
constant: false
name: _AU149534_1_c
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:AU149534

metaR HSPGtly
kinetic law: MODEL1310110053#
reversible: false
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110053#
product: MODEL1310110053#
name: heparan sulfate transport, extracellular to lysosome
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110053#_e613786f_46c1_44df_91a5_0cccca33c6e4
initial amount: NaN
is encoded by: hsa:9435
constant: false
is: Q9Y4C5
name: CHST2
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true

metaR ALR3
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
fast: false
name: aldose reductase (acetol)
is version of: http://identifiers.org/ec-code/1.1.1.21
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000269
product: MODEL1310110053#
reversible: false
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD

metaR r2108
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110053#
reversible: true
modifier: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR G3PD1
kinetic law: MODEL1310110053#
type: Reaction
is described by: ECO:0000269
reversible: true
fast: false
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
product: MODEL1310110053#
name: glycerol-3-phosphate dehydrogenase (NAD)
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.1.1.8
is: SBO:0000176

metaM hs deg14 l
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: heparan sulfate, degradation product 14
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:16126

metaR 5OXPROt
name: Transport of 5-oxoprolinate
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000134

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaM 4abut m
type: Species
is: CHEBI:16865
boundary condition: false
name: 4-Aminobutanoate
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
has only substance units: false
constant: false
is: HMDB00112
is: C00334
initial amount: NaN
initial concentration: 1.0

metaM pnto R e
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
initial concentration: 1.0
constant: false
is: HMDB00210
is: CHEBI:7916
has only substance units: false
name: (R)-Pantothenate

metaM eicostetcoa c
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
initial concentration: 1.0
is: C16164
name: eicosatetranoyl coenzyme A
boundary condition: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_6528139c_6df5_4c25_83b5_8bbaee39e943
initial concentration: NaN
boundary condition: true
is: P43353
constant: false
name: ALDH3B1
has only substance units: false
is encoded by: hsa:221
type: Species
initial amount: NaN
is: SBO:0000252

metaM dgdp m
is: CHEBI:58595
name: dGDP(2-)
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00960

metaR r0330
reversible: false
is described by: ECO:0000000
fast: false
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
is: SBO:0000176

metaM fmn c
boundary condition: false
is: SBO:0000247
is: C00061
is: HMDB01520
name: FMN
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:58210
initial concentration: 1.0
type: Species
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061

metaM lac L e
constant: false
initial concentration: 1.0
is: HMDB00190
boundary condition: false
is: SBO:0000247
name: (S)-lactate
initial amount: NaN
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: CHEBI:16651
has only substance units: false

metaR AG13T6g
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110053#
fast: false
product: MODEL1310110053#
reactant: MODEL1310110053#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110053#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149

http://identifiers.org/biomodels.db/MODEL1310110053#_f14b6efc_3518_48d2_a7bb_8699e76def03
type: Species
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3423
is: B4DGD7
initial amount: NaN
name: IDS
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_a2e1cac8_ccfb_4e2e_a405_3ba807d93cea
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6581
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
name: SLC22A3
type: Species
is: Q5SYN6

metaR r0208
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
is described by: ECO:0000000
product: MODEL1310110053#
reversible: true
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/4.4.1.1

metaM Ser Gly Ala X Gly l
is: C00318
constant: false
notes: FORMULA: XH CHARGE: 0
initial concentration: 1.0
name: protein-linked serine residue (glycosaminoglycan attachment site)
is: SBO:0000247
is: CHEBI:16347
has only substance units: false
boundary condition: false
is: HMDB00062
type: Species
initial amount: NaN

metaR r1640
product: MODEL1310110053#
modifier: MODEL1310110053#
type: Reaction
fast: false
reactant: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaM pmtcoa r
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: CHEBI:3454
is: C00154
constant: false
boundary condition: false
name: Palmitoyl-CoA (n-C16:0CoA)
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01338
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_e6755480_7f98_4d47_8747_4aca5c3313ed
is encoded by: hsa:81031
initial amount: NaN
is: O95528
type: Species
boundary condition: true
initial concentration: NaN
name: SLC2A10
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_90895be6_84a2_4566_814f_f460ea49f7c3
boundary condition: true
name: _AA977580_1_c
initial amount: NaN
is encoded by: hsa:AA977580
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN

metaM CE0713 m
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
constant: false
is: CHEBI:30623
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB02329
is: SBO:0000247
name: 3-oxolinoleoyl-CoA

metaR ALR2
fast: false
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is described by: ECO:0000269
type: Reaction
name: aldose reductase (methylglyoxal)
product: MODEL1310110053#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.21
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.1.1.2

http://identifiers.org/biomodels.db/MODEL1310110053#_7e8e23d2_67e2_45c2_883b_5121d5dd0050
initial concentration: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
name: ACADM
is: SBO:0000252
initial amount: NaN
is: P11310
is encoded by: hsa:34

metaR r2107
modifier: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110053#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110053#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110053#_253564a1_0de5_4c5b_8b3b_5ebc336b6c69
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2348
type: Species
name: FOLR1

metaR 34DHXMANDACOX NADP
modifier: MODEL1310110053#
is: SBO:0000176
product: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
reversible: true
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
is described by: ECO:0000269
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false

metaM dgdp n
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: HMDB00960
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
name: dGDP(2-)
type: Species
is: CHEBI:58595
initial concentration: 1.0
boundary condition: false

metaR DNDPt21m
is: SBO:0000185
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
reversible: false
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000269
type: Reaction
name: dTDP transport via ADP antiport

http://identifiers.org/biomodels.db/MODEL1310110053#_cc001d71_26d2_4965_be5a_df7241735c6e
name: ALG1
is: SBO:0000252
type: Species
has only substance units: false
is: Q9BT22
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:56052

http://identifiers.org/biomodels.db/MODEL1310110053#_e36a1978_61e0_42c1_b9b3_5053c451b251
initial amount: NaN
type: Species
name: GCAT
is: SBO:0000252
is: E2QC23
is encoded by: hsa:23464
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false

metaM arachcoa c
initial amount: NaN
is: HMDB04258
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
name: arachidyl coenzyme A
is: SBO:0000247
has only substance units: false
is: CHEBI:15527

metaR DNDPt17m
name: dUDP transport via dCDP antiport
reversible: false
modifier: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
kinetic law: MODEL1310110053#
is: SBO:0000185

metaR DESAT20 1
is: SBO:0000176
type: Reaction
product: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
kinetic law: MODEL1310110053#
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110053#

metaR r1643
kinetic law: MODEL1310110053#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#
reversible: true
fast: false
is: SBO:0000185
type: Reaction

metaR r2193
product: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110053#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reversible: true

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_deceaf0b_d9fe_479c_adaa_27e864202567
initial concentration: NaN
type: Species
is: SBO:0000252
name: ST3GAL3
constant: false
is encoded by: hsa:6487
boundary condition: true
has only substance units: false
initial amount: NaN

metaM CE2705 c
constant: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
is: SBO:0000247
is: CHEBI:52328
initial concentration: 1.0
initial amount: NaN
name: quinonoid dihydrobiopterin
boundary condition: false
type: Species
has only substance units: false

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaR r2048
modifier: MODEL1310110053#
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000185
kinetic law: MODEL1310110053#

metaM pnto R c
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00210
is: CHEBI:7916
initial concentration: 1.0
boundary condition: false
name: (R)-Pantothenate
is: SBO:0000247
type: Species

metaM HC01842 c
constant: false
type: Species
name: Phosphodimethylethanolamine
is: CHEBI:31997
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)

http://identifiers.org/biomodels.db/MODEL1310110053#_23f87c4b_8ab4_4347_ad7c_192dc47ce2e4
initial amount: NaN
name: SLC2A8
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:29988
is: Q9NY64
has only substance units: false

metaM lnlccoa c
is: http://identifiers.org/pubchem.compound/5462164
has only substance units: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
initial concentration: 1.0
constant: false
type: Species
name: linoleic coenzyme A
initial amount: NaN
is: HMDB01064
boundary condition: false
is: SBO:0000247

metaR UGALNACtg
kinetic law: MODEL1310110053#
is described by: ECO:0000269
reactant: MODEL1310110053#
name: UDP-GalNAc Golgi transport via CMP antiport
reversible: true
type: Reaction
product: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
modifier: MODEL1310110053#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_2fc2c054_aa73_4ede_99df_ce00b6226c81
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:284111
initial concentration: NaN
name: SLC13A5
type: Species
is: Q86YT5

metaM fald c
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB01426
has only substance units: false
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
name: formaldehyde
initial concentration: 1.0
is: CHEBI:16842

http://identifiers.org/biomodels.db/MODEL1310110053#_13fb72e7_5ce7_4755_b67a_badc71ca49ba
boundary condition: true
is encoded by: hsa:10195
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species
name: ALG3

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_18236a9a_3753_439b_89f6_21126df94804
is: Q8IWW8
is encoded by: hsa:137872
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
type: Species
name: ADHFE1
boundary condition: true
initial concentration: NaN

metaR DESAT20 2
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reversible: false
name: fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)
product: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
is described by: ECO:0000000
modifier: MODEL1310110053#
is: SBO:0000176
kinetic law: MODEL1310110053#
type: Reaction

metaR PIter
reversible: true
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
product: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
modifier: MODEL1310110053#
name: phosphate transport, endoplasmic reticulum
is: SBO:0000185

metaR r0545
reactant: MODEL1310110053#
is: SBO:0000176
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110053#
fast: false
type: Reaction
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
product: MODEL1310110053#
is described by: ECO:0000000

metaR r0926
reactant: MODEL1310110053#
name: Postulated transport reaction
kinetic law: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110053#
is: SBO:0000185
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:

metaR r0331
is: SBO:0000176
kinetic law: MODEL1310110053#
is described by: ECO:0000000
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
reversible: false
reactant: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
fast: false
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1

metaR r2194
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
modifier: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
kinetic law: MODEL1310110053#
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110053#

metaR r1642
type: Reaction
reactant: MODEL1310110053#
product: MODEL1310110053#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110053#
is: SBO:0000185
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_431146a1_2822_450b_8d91_9324b548a1b6
is encoded by: hsa:7498
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P47989
is: SBO:0000252
boundary condition: true
type: Species
name: XDH
constant: false

metaR r2109
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_e2ac61a0_36ce_4dd1_a8d5_3d9e587b8274
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: P31937
is encoded by: hsa:11112
name: HIBADH

metaM ksi pre13 g
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
name: keratan sulfate I biosynthesis, precursor 13
is: SBO:0000247
is: CHEBI:58053
initial amount: NaN
boundary condition: false
is: HMDB00175
initial concentration: 1.0
is: C00130
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_87a899bf_8b61_4e92_8e17_c46d9fe4508f
is encoded by: hsa:3158
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
name: HMGCS2
constant: false
is: P54868
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_33ce1f03_32de_4845_8fee_daa786886043
boundary condition: true
name: _AI640625_1_c
constant: false
is encoded by: hsa:AI640625
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaM pro L m
is: HMDB00162
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
boundary condition: false
name: L-proline
is: CHEBI:17203
is: SBO:0000247

metaR MDRPD
is: SBO:0000176
reactant: MODEL1310110053#
product: MODEL1310110053#
name: 5-Methylthio-5-deoxy-D-ribulose 1-phosphate dehydratase
reversible: false
type: Reaction
kinetic law: MODEL1310110053#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:JLR- Based on reaction given for B. subtilis (Sekowska A and A. Danchin paper(2002) )

metaM 3uib c
initial amount: NaN
constant: false
is: HMDB02031
boundary condition: false
has only substance units: false
is: CHEBI:1670
is: SBO:0000247
notes: FORMULA: C5H9N2O3 CHARGE: -1 INCHI: InChI=1S/C5H10N2O3/c1-3(4(8)9)2-7-5(6)10/h3H,2H2,1H3,(H,8,9)(H3,6,7,10) HEPATONET_1.0_ABBREVIATION: HC01371 EHMN_ABBREVIATION: C05100
initial concentration: 1.0
type: Species
name: 3-Ureidoisobutyrate

metaM nac e
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: C00253
is: HMDB01488
initial concentration: 1.0
is: SBO:0000247
name: Nicotinate
is: CHEBI:0
notes: FORMULA: C6H4NO2 CHARGE: -1
type: Species

metaR r2104
kinetic law: MODEL1310110053#
is: SBO:0000185
fast: false
modifier: MODEL1310110053#
product: MODEL1310110053#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110053#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110053#_4c9710e0_648b_4287_b98e_b583bbe6e851
constant: false
name: SLC38A2
initial concentration: NaN
type: Species
is: Q96QD8
has only substance units: false
is encoded by: hsa:54407
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR r1434
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110053#
is: SBO:0000185
kinetic law: MODEL1310110053#
reversible: false
name: Transport reaction
type: Reaction
reactant: MODEL1310110053#
is described by: ECO:0000000
fast: false

metaM strdnc r
initial amount: NaN
name: stearidonic acid C18:4, n-3
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
has only substance units: false
is: C16300
is: HMDB06547
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/47205608

metaM prpp e
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00280
initial concentration: 1.0
is: CHEBI:58017
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
is: SBO:0000247
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
has only substance units: false
type: Species

metaR r0653
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
fast: false
is: SBO:0000176
product: MODEL1310110053#
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110053#
reversible: false
reactant: MODEL1310110053#
type: Reaction
is described by: ECO:0000000

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

metaM gdp n
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: CHEBI:58189
boundary condition: false
name: GDP(3-)
type: Species
initial amount: NaN
is: HMDB01201
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_e018b3a7_d417_497d_b5af_8ea0217bbf88
is: P15954
name: COX7C
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:1350
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR EX caro LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Carotene exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_5471eb92_1531_44e3_ac28_af60eece3c64
name: PTDSS2
initial amount: NaN
constant: false
is: Q9BVG9
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:81490

http://identifiers.org/biomodels.db/MODEL1310110053#_d30315bf_ff59_4ca4_b968_1817080b11dd
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q6ZWP6
boundary condition: true
is encoded by: hsa:27034
name: ACAD8
constant: false

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

metaR r2103
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110053#
reversible: true
kinetic law: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110053#
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_b8e7c380_74da_47f9_97d7_87aef3f1b03b
constant: false
initial amount: NaN
type: Species
is: P16930
is: SBO:0000252
name: FAH
is encoded by: hsa:2184
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR VALt5m
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reversible: true
name: Valine reversible mitochondrial transport
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110053#
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#

metaM c226coa x
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205479
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: C16169
name: cervonyl coenzyme A

metaR GLCNACASE2ly
type: Reaction
product: MODEL1310110053#
modifier: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
name: alpha-N-acetylglucosaminidase, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.50
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_983f0ffe_d99b_409a_acd1_d9c2850c280e
initial amount: NaN
name: DPYSL2
is: SBO:0000252
is encoded by: hsa:1808
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: B4DR31

http://identifiers.org/biomodels.db/MODEL1310110053#_0cda304c_d00a_447c_813c_d4d2b4ad2b0c
has only substance units: false
boundary condition: true
is: P23921
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:6240
name: RRM1

metaR DM dttp m
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dTTP demand
type: Reaction

metaR r0652
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
modifier: MODEL1310110053#
product: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true
reactant: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false

metaM nac c
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: C00253
initial concentration: 1.0
is: HMDB01488
name: Nicotinate
is: SBO:0000247
notes: FORMULA: C6H4NO2 CHARGE: -1
is: CHEBI:0
boundary condition: false

metaR GLYC St
is described by: ECO:0000000
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000185
fast: false
reversible: false
type: Reaction
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:9604805 NOTES:
name: L-glycerate export

http://identifiers.org/biomodels.db/MODEL1310110053#_2170810b_c4ed_4bb1_8d1f_af358ad00a4b
constant: false
boundary condition: true
name: DHFR
type: Species
is encoded by: hsa:1719
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P00374
has only substance units: false

metaR DOPAtu
type: Reaction
modifier: MODEL1310110053#
is: SBO:0000185
name: Dopamine uniport
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110053#
fast: false
reversible: true
product: MODEL1310110053#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110053#_8d695998_fc81_4114_a678_0b03c70cbce2
name: FADS1
is encoded by: hsa:3992
initial amount: NaN
constant: false
type: Species
is: O60427
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_824baebe_cc6f_4669_9756_3fef24d5778e
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
has only substance units: false
name: ACAA2
is: P42765
is encoded by: hsa:10449

http://identifiers.org/biomodels.db/MODEL1310110053#_226280d3_5365_4990_965b_07dc11db76d6
is encoded by: hsa:768
type: Species
has only substance units: false
name: CA9
is: Q16790
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false

metaR AGPAT1
is: SBO:0000176
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.3.1.15
reactant: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (10555.1) or (137964.1) or (56895.1) or (56894.2) or (56894.1) or (55326.1) or (10554.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 2.3.1.51 Confidence Level: 4 AUTHORS: NOTES:FULLR corresponds to acyl/R groups in texts. NJ
name: 1-acylglycerol-3-phosphate O-acyltransferase 1
type: Reaction
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.3.1.51

metaR r2106
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#

metaM n2m2nmasn l
has only substance units: false
initial amount: NaN
notes: FORMULA: C58H96N5O40X CHARGE: 0
is: C04946
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
boundary condition: false

metaM Ser Thr g
has only substance units: false
notes: FORMULA: XH CHARGE: 0
initial concentration: 1.0
is: CHEBI:58336
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
name: protein-linked serine or threonine residue (O-glycosylation site)
is: HMDB00645
boundary condition: false

metaM acgam c
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00215
is: CHEBI:17411
is: SBO:0000247
name: N-acetyl-D-glucosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial concentration: 1.0
constant: false

metaM ha deg1 l
name: hyaluronan degradation product 1
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:16336
initial amount: NaN
notes: FORMULA: C22H33N2O16 CHARGE: -1
constant: false

metaM prpp c
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: C00119
is: HMDB00280
is: CHEBI:58017
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
name: 5-Phospho-alpha-D-ribose 1-diphosphate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_a2edb6e7_db62_4e9a_9614_12f5ce5f8b46
name: PANK2
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:80025
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false

metaR r0441
is version of: http://identifiers.org/ec-code/2.7.1.40
product: MODEL1310110053#
type: Reaction
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
fast: false
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
kinetic law: MODEL1310110053#
is: SBO:0000176
reversible: true
modifier: MODEL1310110053#
is described by: ECO:0000000
reactant: MODEL1310110053#

metaR r0655
modifier: MODEL1310110053#
is: SBO:0000176
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
kinetic law: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.2
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_f3079d52_afdd_4b62_a4fe_df7a68e31cdd
is: SBO:0000252
name: TM7SF2
is: O76062
constant: false
is encoded by: hsa:7108
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR CHSTEROLt3
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
type: Reaction
kinetic law: MODEL1310110053#
name: cholesterol intracellular transport
is described by: ECO:0000000
product: MODEL1310110053#
reversible: true
reactant: MODEL1310110053#
fast: false
is: SBO:0000185

metaR r0130
modifier: MODEL1310110053#
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000176
product: MODEL1310110053#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_a2612ffa_ed47_465b_9e38_f3efc98c674d
boundary condition: true
name: SLC25A4
constant: false
initial amount: NaN
is encoded by: hsa:291
is: P12235
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR r2105
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
modifier: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
fast: false
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_b9672942_543c_4f41_9606_5707a958ddc6
constant: false
type: Species
boundary condition: true
is: Q5FC00
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:765
name: CA6
is: SBO:0000252

metaR DM anth
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR H2Otm
fast: false
reactant: MODEL1310110053#
modifier: MODEL1310110053#
is described by: ECO:0000269
kinetic law: MODEL1310110053#
type: Reaction
reversible: true
product: MODEL1310110053#
name: H2O transport, mitochondrial
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
is: SBO:0000185

metaM lac L c
is: CHEBI:16651
type: Species
constant: false
name: (S)-lactate
is: HMDB00190
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
boundary condition: false

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaR NADtx
kinetic law: MODEL1310110053#
is described by: ECO:0000134
fast: false
reactant: MODEL1310110053#
name: transport of NAD into peroxisome
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaM bilirub r
boundary condition: false
initial amount: NaN
name: bilirubin(2-)
is: CHEBI:57977
is: HMDB00054
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_05ae824b_f344_4264_ba47_775ba5676686
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:10317
constant: false
name: B3GALT5
has only substance units: false
is: SBO:0000252

metaR r0779
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
fast: false
reactant: MODEL1310110053#
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
kinetic law: MODEL1310110053#
reversible: false
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
is: SBO:0000176
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM pmtcoa x
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: C00154
is: CHEBI:57379
is: SBO:0000247
initial amount: NaN
is: HMDB01338
name: Palmitoyl-CoA (n-C16:0CoA)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_ce4f7cee_4e8a_4ddb_ac3c_4331f9d43a6b
is encoded by: hsa:230
boundary condition: true
is: SBO:0000252
name: ALDOC
is: P09972
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
constant: false

metaR r0817
product: MODEL1310110053#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.41
modifier: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_10ac0a2f_4eb4_4d7d_b03e_00e4e70799f2
initial amount: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
is: P23378
is: SBO:0000252
initial concentration: NaN
name: GLDC
is encoded by: hsa:2731

http://identifiers.org/biomodels.db/MODEL1310110053#_4a1e42e8_79c7_46af_8500_9da878d964db
name: ALDH3B2
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:222
constant: false
type: Species
is: P48448
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_b096d2aa_b9e1_410e_b30d_584de9e1fa78
is encoded by: hsa:4247
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q10469
constant: false
name: MGAT2
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_5b321f6a_b702_4871_8639_9f7c29c4b888
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1644
is: Q53Y41
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: DDC
boundary condition: true

metaM sbt D e
constant: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
boundary condition: false
type: Species
initial concentration: 1.0
name: D-glucitol
is: HMDB00247
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM arachcoa m
is: SBO:0000247
is: CHEBI:15527
has only substance units: false
type: Species
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
initial concentration: 1.0
initial amount: NaN
is: HMDB04258
name: arachidyl coenzyme A
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_46845946_7f99_4e34_a673_17e4e43fd593
constant: false
is: P04745
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: AMY1C
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:278

http://identifiers.org/biomodels.db/MODEL1310110053#_0db9f0b1_1a36_454a_8672_7578d831219c
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
name: CHST5
has only substance units: false
is encoded by: hsa:23563
initial concentration: NaN

metaR ALDD2xm
modifier: MODEL1310110053#
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
fast: false
is described by: ECO:0000134
reactant: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000176
reversible: false
type: Reaction

metaR r0443
is described by: ECO:0000000
modifier: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
fast: false
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reactant: MODEL1310110053#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110053#

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaM asp L c
constant: false
has only substance units: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
boundary condition: false
name: L-aspartate(1-)
is: HMDB00191
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:29991
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_b0a20c04_1f3a_42c2_a12c_1c2ef8873b3c
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: ENPP3
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:5169
is: Q308M7

metaM CE2431 m
initial amount: NaN
constant: false
is: C01936
boundary condition: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
name: cis-deca-4-enoyl-CoA

metaR r2100
type: Reaction
reversible: true
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110053#
modifier: MODEL1310110053#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_e1d10661_f235_462e_a938_3f2ea77225c7
is: SBO:0000252
initial amount: NaN
name: ALDH9A1
type: Species
initial concentration: NaN
has only substance units: false
is: P49189
boundary condition: true
constant: false
is encoded by: hsa:223

metaR r0774
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110053#
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM m5mpdol U r
is: CHEBI:37634
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1545H2540N20O470P20 CHARGE: -20

metaM ksii core2 pre4 g
name: keratan sulfate II biosynthesis, precursor 4
is: HMDB00175
has only substance units: false
notes: FORMULA: C53H86N4O38X CHARGE: -1
boundary condition: false
is: SBO:0000247
is: CHEBI:58053
type: Species
is: C00130
constant: false
initial concentration: 1.0
initial amount: NaN

metaM pe hs e
type: Species
constant: false
is: CHEBI:16038
initial amount: NaN
name: phosphatidylethanolamine
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
boundary condition: false

metaM 44mctr r
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
is: CHEBI:17813
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB01023
is: SBO:0000247
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_51bcf663_ea01_4a44_8cb8_2c91011406af
has only substance units: false
name: MAN1B1
is: Q9UKM7
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:11253
initial amount: NaN

metaR H2Otg
name: H2O transport, Golgi apparatus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110053#
fast: false
product: MODEL1310110053#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110053#
reversible: true

metaM gthox m
is: CHEBI:58297
is: SBO:0000247
is: HMDB03337
type: Species
has only substance units: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false

metaR r0068
type: Reaction
is: SBO:0000176
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (134526.1) SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
reactant: MODEL1310110053#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.1.2.1
modifier: MODEL1310110053#
name: Acetyl adenylate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1

http://identifiers.org/biomodels.db/MODEL1310110053#_d8ce2fce_75ac_43e9_bdec_c83fd734d799
type: Species
initial amount: NaN
name: DPM3
boundary condition: true
is encoded by: hsa:54344
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q86TM7
constant: false

metaR r1431
is described by: ECO:0000000
reversible: false
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
reactant: MODEL1310110053#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110053#
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_91d29168_b912_46a8_b2f8_0427f2f9e09b
has only substance units: false
is: A8K8P8
initial concentration: NaN
initial amount: NaN
name: FUT8
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:2530
boundary condition: true

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_3824300e_14be_42ae_bfb9_02f7c091f885
initial amount: NaN
type: Species
is encoded by: hsa:64841
initial concentration: NaN
boundary condition: true
constant: false
is: Q96EK6
name: GNPNAT1
is: SBO:0000252
has only substance units: false

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaM C04853 r
initial amount: NaN
is: HMDB01509
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:57460
is: SBO:0000247
name: 20-hydroxy-leukotriene B4(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c21-17-10-6-2-1-3-7-12-18(22)13-8-4-5-9-14-19(23)15-11-16-20(24)25/h3-5,7-9,13-14,18-19,21-23H,1-2,6,10-12,15-17H2,(H,24,25)/p-1/b5-4+,7-3-,13-8+,14-9-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C04853
constant: false
boundary condition: false

metaR RE0383C
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
reactant: MODEL1310110053#
modifier: MODEL1310110053#
product: MODEL1310110053#
name: RE0383
kinetic law: MODEL1310110053#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
fast: false

metaR r2102
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
is: SBO:0000185
product: MODEL1310110053#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110053#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR RE1530C
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
reactant: MODEL1310110053#
fast: false
product: MODEL1310110053#
kinetic law: MODEL1310110053#
name: RE1530
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110053#_62f8aea8_d0b8_40ce_97e7_00f58d454cbe
name: UGT1A8
has only substance units: false
is encoded by: hsa:54576
initial amount: NaN
is: Q5DSZ6
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial concentration: NaN

metaM Ser Thr l
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
name: protein-linked serine or threonine residue (O-glycosylation site)
type: Species
is: CHEBI:58190
is: SBO:0000247
is: HMDB00224
notes: FORMULA: XH CHARGE: 0

metaM 6thf e
boundary condition: false
is: http://identifiers.org/pubchem.compound/169691
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
has only substance units: false
type: Species
name: hexaglutamyl folate (THF)
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaR HSAT3ly
type: Reaction
reversible: false
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
is described by: ECO:0000000
product: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
is: SBO:0000185
name: heparan-glucosaminide N-acetyltransferase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110053#_fb155101_5d06_4609_9255_025f4bafea88
constant: false
name: CA5B
initial amount: NaN
boundary condition: true
is: Q9Y2D0
is: SBO:0000252
is encoded by: hsa:11238
initial concentration: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_12c40308_3cba_4e6c_ae00_523c2bf896fc
type: Species
name: NDUFAB1
constant: false
is encoded by: hsa:4706
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is: O14561

metaR NACDe
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

metaM gdp m
is: C00035
is: SBO:0000247
name: GDP
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
constant: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: CHEBI:58189
initial concentration: 1.0
is: HMDB01201

metaM sbt D c
initial amount: NaN
initial concentration: 1.0
is: HMDB00247
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
type: Species
name: D-glucitol
is: CHEBI:17924

metaM 34dhpac c
has only substance units: false
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: HMDB03791
is: CHEBI:27978
is: SBO:0000247
name: 3,4-Dihydroxyphenylacetaldehyde
type: Species

metaR CORE6GTg
is version of: http://identifiers.org/ec-code/2.4.1.102
product: MODEL1310110053#
is: SBO:0000176
kinetic law: MODEL1310110053#
reversible: false
is described by: ECO:0000000
name: Core 6 beta-GlcNAc-transferase A, Golgi apparatus
modifier: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (2650.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_d4625a72_2cdf_40bf_91f9_d52bd45301c3
is encoded by: hsa:2987
initial amount: NaN
type: Species
is: Q16774
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
name: GUK1

metaM fprica c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:58467
has only substance units: false
constant: false
is: C04734
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
boundary condition: false
is: HMDB01439

metaR r2040
is: SBO:0000185
modifier: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
type: Reaction
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_34ee8199_a49d_4d5c_9363_c13f42e4767f
constant: false
name: NDUFA1
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4694
has only substance units: false
is: SBO:0000252
is: Q6IBB5
initial amount: NaN
type: Species

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

metaR SERGLYexR
modifier: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110053#
name: L-Serine/Glycine reversible exchange
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110053#

metaR GF6PTA
product: MODEL1310110053#
is: SBO:0000176
name: glutamine-fructose-6-phosphate transaminase
modifier: MODEL1310110053#
is described by: ECO:0000269
reversible: false
type: Reaction
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.16
notes: GENE_ASSOCIATION: (2673.1) or (9945.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.6.1.16 Confidence Level: 4 AUTHORS: PMID:10198162,PMID:11842094,PMID:1460020 NOTES:

metaR ACACT10m
is described by: ECO:0000134
modifier: MODEL1310110053#
name: acetyl-CoA C-acetyltransferase, mitochondrial
is version of: http://identifiers.org/ec-code/2.3.1.9
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
reversible: true
is: SBO:0000176
reactant: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
fast: false
kinetic law: MODEL1310110053#

metaM HC02149 m
type: Species
is: CHEBI:28867
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
constant: false
name: O-Propanoylcarnitine
initial amount: NaN
has only substance units: false

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaM retinol cis 11 c
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:16302
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
has only substance units: false
name: 11-cis-retinol
constant: false
is: SBO:0000247
is: HMDB06216
initial amount: NaN

metaR RE2998M
modifier: MODEL1310110053#
name: RE2998
is described by: ECO:0000000
reactant: MODEL1310110053#
fast: false
reversible: false
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110053#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_616529e9_047a_4803_b76a_fd52a1a4bc6a
is encoded by: hsa:195814
name: SDR16C5
is: B3KT84
type: Species
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR HACD9m
kinetic law: MODEL1310110053#
fast: false
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
modifier: MODEL1310110053#
type: Reaction
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
reactant: MODEL1310110053#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110053#

metaR r2041
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_cf443a2d_5582_4695_8dea_57ddb8e2edc6
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10087
initial amount: NaN
name: COL4A3BP
type: Species
initial concentration: NaN
is: Q9Y5P4
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_ab9ff8ff_b80f_40c8_8ba1_29c79e90ca5b
type: Species
name: ALDH9A1
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:223
is: P49189
initial concentration: NaN

metaR r1433
product: MODEL1310110053#
kinetic law: MODEL1310110053#
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
reversible: false
fast: false
reactant: MODEL1310110053#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

metaR r2101
modifier: MODEL1310110053#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110053#
type: Reaction
is: SBO:0000185
reversible: true

metaM pro L c
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
has only substance units: false
is: HMDB00162
constant: false
name: L-proline
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:17203
initial concentration: 1.0
is: SBO:0000247

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_c936db63_fd7b_4f91_8d58_5774d376490d
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:92483
name: LDHAL6B
type: Species
is: Q9BYZ2
initial amount: NaN
boundary condition: true

metaR q10h2tc
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110053#
name: transport of ubiquinol into cytosol
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_513ece28_0fca_4e9b_b620_63413a3a21e6
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:AI469183
name: _AI469183_1_x
constant: false

metaR r0434
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
product: MODEL1310110053#
is described by: ECO:0000000

metaR r1527
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
type: Reaction
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
is version of: http://identifiers.org/ec-code/4.2.1.1
is: SBO:0000185
reactant: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
fast: false
reversible: false
product: MODEL1310110053#

metaM cmpacna n
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:57812
initial concentration: 1.0
is: SBO:0000247
is: HMDB01176
name: CMP-N-acetyl-beta-neuraminate(2-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_b49f72ba_02df_4c49_8851_ff01e4bbc5fc
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:23057
name: NMNAT2
initial concentration: NaN

metaM coa x
boundary condition: false
name: Coenzyme A
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB01423
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: C00010
constant: false
initial concentration: 1.0
is: CHEBI:57287

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaR S2TASE1ly
fast: false
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
name: iduronate-2-sulfatase, lysosomal
reversible: false
reactant: MODEL1310110053#
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.1.6.13
is: SBO:0000176
modifier: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#

metaM m7masnB g
boundary condition: false
type: Species
is: C05881
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C64H107N2O50X CHARGE: 0
has only substance units: false
constant: false
initial concentration: 1.0

metaR r2330
fast: false
is: SBO:0000185
product: MODEL1310110053#
reversible: true
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM ru5p D c
name: D-ribulose 5-phosphate(2-)
initial amount: NaN
is: CHEBI:58121
type: Species
constant: false
has only substance units: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: HMDB00618
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR DCMPDA
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.12
fast: false
name: dCMP deaminase
is: SBO:0000176
type: Reaction
reactant: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
is described by: ECO:0000254
product: MODEL1310110053#
kinetic law: MODEL1310110053#

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_277c8e44_c5c7_40be_b6c2_9228d02383c4
name: NDUFB8
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:4714
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is: O95169

metaM csn c
is: CHEBI:16040
name: cytosine
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
constant: false
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
is: SBO:0000247
initial concentration: 1.0
is: HMDB00630

metaM 4abutn m
constant: false
is: HMDB01080
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 4-ammoniobutanal
is: CHEBI:58264
has only substance units: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
initial concentration: 1.0
type: Species

metaR r0782
kinetic law: MODEL1310110053#
is: SBO:0000176
name: GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) Fructose and mannose metabolism EC:1.1.1.271
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: PMID:10410995,PMID:2428310,PMID:9603974 NOTES:
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_b3ccbfc5_e345_4336_ad5f_ad1f92ce3033
name: SLC6A14
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:11254
type: Species
is: SBO:0000252
is: Q9UN76
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_ffd7c4a3_39a3_45d0_bc9b_ab1b9c5e9021
is encoded by: hsa:1633
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: DCK
type: Species
constant: false
is: P27707
has only substance units: false

metaM Asn X Ser Thr l
name: protein-linked asparagine residue (N-glycosylation site)
is: CHEBI:28938
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: C01342
constant: false
is: HMDB00051
type: Species
notes: FORMULA: XH CHARGE: 0
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_37124e31_d454_4d04_846a_7e04e6b4ea4f
is encoded by: hsa:10559
is: SBO:0000252
is: P78382
constant: false
type: Species
name: SLC35A1
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_38ccd65f_427d_46ae_869f_ab68bc1a2c58
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:26289
boundary condition: true
name: AK5
is: Q9Y6K8
type: Species
is: SBO:0000252

metaR TSTSTERONEtr
reversible: true
kinetic law: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
name: testosterone intracellular transport
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

http://identifiers.org/biomodels.db/MODEL1310110053#_15f9d8ff_8b61_4525_a01b_2cfa12705879
constant: false
initial concentration: NaN
is encoded by: hsa:2805
is: SBO:0000252
name: GOT1
initial amount: NaN
has only substance units: false
type: Species
is: P17174
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_e670a6c6_c722_4530_a05e_669c17956cf9
initial concentration: NaN
is: Q9GZX3
is: SBO:0000252
name: CHST6
boundary condition: true
is encoded by: hsa:4166
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaR CYTK14n
fast: false
reversible: true
name: cytidylate kinase (dCMP,CTP),nuclear
reactant: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110053#
is: SBO:0000176
modifier: MODEL1310110053#
is described by: ECO:0000269
kinetic law: MODEL1310110053#

metaM dheas c
constant: false
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
boundary condition: false
is: HMDB01032
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:57905
has only substance units: false
initial concentration: 1.0

metaR r0783
reactant: MODEL1310110053#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_24e137c9_8b73_4f08_a17a_42d3379b6df0
constant: false
is: P51648
type: Species
name: ALDH3A2
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:224
has only substance units: false
is: SBO:0000252

metaM pro L e
constant: false
name: L-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: SBO:0000247
type: Species
is: CHEBI:17203
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00162
initial concentration: 1.0

metaR ASNtN1
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
fast: false
type: Reaction
name: Asparagine transport (Na, H coupled)
modifier: MODEL1310110053#
is described by: ECO:0000269
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_c49e86a8_678d_43bb_b2b4_f48fb57d093b
is: O75438
initial concentration: NaN
initial amount: NaN
name: NDUFB1
boundary condition: true
type: Species
constant: false
is encoded by: hsa:4707
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_44df5c19_8c76_4b80_9ec7_90dd615729c0
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:386757
name: SLC6A10P
boundary condition: true

metaM ptth m
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: CHEBI:16753
boundary condition: false
is: SBO:0000247
type: Species
name: pantetheine
initial amount: NaN
is: HMDB03426
has only substance units: false
constant: false
initial concentration: 1.0

metaR RE3272N
product: MODEL1310110053#
reversible: true
is: SBO:0000176
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110053#
type: Reaction
name: RE3272

metaR r1847
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000185
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
fast: false
type: Reaction
reversible: false
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110053#

metaM HC02214 c
has only substance units: false
is: CHEBI:28852
is: SBO:0000247
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
constant: false
initial concentration: 1.0
initial amount: NaN
name: prostaglandin-f1alpha
type: Species
boundary condition: false

metaR r2332
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_651b8b3a_b0c4_4af9_bd92_00110fc0916e
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:10935
is: SBO:0000252
initial amount: NaN
constant: false
name: PRDX3
is: E9PH29

metaR r0062
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.1 Confidence Level: 0 AUTHORS: PMID:11322891,PMID:12545200,PMID:16951743,PMID:34392,PMID:6151837,PMID:7696329 NOTES:
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/4.3.1.17
is: SBO:0000176
reactant: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
fast: false
name: Acetyl-CoA hydrolase Pyruvate metabolism EC:3.1.2.1
reversible: false

metaM 3hpcoa m
name: 3-hydroxypropanoyl-CoA(4-)
is: HMDB06807
type: Species
is: SBO:0000247
is: CHEBI:58528
initial concentration: 1.0
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN

metaM csn e
boundary condition: false
is: HMDB00630
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
is: CHEBI:16040
name: cytosine
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false

metaM pi c
constant: false
name: hydrogenphosphate
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2
is: CHEBI:43474
has only substance units: false
type: Species
is: C00009
is: HMDB00973

http://identifiers.org/biomodels.db/MODEL1310110053#_283a452f_f95c_4447_a2cf_93272dafa7f5
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:257068
name: PLCXD2
is: Q0VAA5
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: true

metaM leu L m
boundary condition: false
is: HMDB00687
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: CHEBI:15603
constant: false
name: L-leucine
has only substance units: false
is: SBO:0000247

metaR MAN1PT2
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
name: mannose-1-phosphate guanylyltransferase (GDP)
reactant: MODEL1310110053#
modifier: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.7.13
kinetic law: MODEL1310110053#
is: SBO:0000176
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_d4d3601e_a411_4d79_b043_30fc78d09cf4
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: DTYMK
boundary condition: true
is: P23919
is encoded by: hsa:1841

metaR r0998
name: Facilitated diffusion
is described by: ECO:0000000
product: MODEL1310110053#
reversible: true
fast: false
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaR r0784
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.38
kinetic law: MODEL1310110053#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110053#
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
reactant: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110053#_cc3d855e_c43d_4272_87af_abde60544239
name: CMPK1
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:51727
has only substance units: false
is: SBO:0000252
boundary condition: true
is: B2R6S5

http://identifiers.org/biomodels.db/MODEL1310110053#_39c3ce62_a7b2_441a_b971_7bc4e7f65086
initial amount: NaN
is: B7Z8Z3
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4051
constant: false
type: Species
name: CYP4F3

metaR r0437
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
product: MODEL1310110053#
is: SBO:0000176
reactant: MODEL1310110053#
fast: false
is version of: http://identifiers.org/ec-code/4.1.2.13
modifier: MODEL1310110053#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
type: Reaction
kinetic law: MODEL1310110053#
reversible: true

metaR PROSTGE2t
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
fast: false
kinetic law: MODEL1310110053#
type: Reaction
reversible: true
name: prostaglandin transport via bicarbonate countertransport
reactant: MODEL1310110053#
modifier: MODEL1310110053#
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110053#

metaR r2331
is described by: ECO:0000000
product: MODEL1310110053#
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_c95ec6c6_9782_4fd9_83a7_7039177bbf45
is: SBO:0000252
name: SRD5A1
is: P18405
initial amount: NaN
is encoded by: hsa:6715
constant: false
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_e68a4d5d_e024_4801_9ddb_42536027799a
has only substance units: false
name: GPAM
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:57678
is: Q8N1G6

http://identifiers.org/biomodels.db/MODEL1310110053#_201f24ae_21e1_4e57_b39a_319dc1c024d3
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: Q9BV79
is encoded by: hsa:51102
is: SBO:0000252
name: MECR
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_bf4803c4_6030_4234_a76e_7bdd8df73218
initial concentration: NaN
is: Q96L53
has only substance units: false
name: ST3GAL3
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:6487
type: Species
is: SBO:0000252

metaR HIBDm
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
reactant: MODEL1310110053#
product: MODEL1310110053#
reversible: true
modifier: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.31
type: Reaction
kinetic law: MODEL1310110053#
fast: false

metaR r2334
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
reactant: MODEL1310110053#
product: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true

metaM HC01522 c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
type: Species
name: Gentisate aldehyde
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:28508
boundary condition: false

metaM 10fthf5glu e
is: HMDB00972
notes: FORMULA: C40H45N11O19 CHARGE: -6
is: CHEBI:57454
name: 10-formyltetrahydrofolate-[Glu](5)
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
type: Species

metaR MM8Ber
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11253.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10409699,PMID:9592125 NOTES:NCD
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.113
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, endoplasmic reticulum
modifier: MODEL1310110053#
is: SBO:0000176
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_4e94bcd1_a06c_4256_8039_196c9c50b1b0
is encoded by: hsa:43
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
name: ACHE
type: Species
is: P22303
constant: false

metaR ARACHCPT1
is described by: ECO:0000000
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
reactant: MODEL1310110053#
modifier: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
name: carnitine transferase
reversible: false
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false

metaM dheas e
is: HMDB01032
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
initial amount: NaN
is: CHEBI:57905
type: Species
boundary condition: false
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)

metaM pi e
name: hydrogenphosphate
is: C00009
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:43474
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: HMDB00973
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR PECDCHe
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of pectins with deoxycholic acid in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaM acgam l
is: CHEBI:17411
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial concentration: 1.0
name: N-acetyl-D-glucosamine
constant: false
is: SBO:0000247
type: Species
is: HMDB00215

metaR RE2814M
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
name: RE2814
product: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
fast: false
is described by: ECO:0000000

metaM HC02149 c
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28867
name: O-Propanoylcarnitine
boundary condition: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3

metaM 3hpp m
boundary condition: false
is: HMDB00700
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16510
name: 3-hydroxypropionate
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
type: Species

metaR r0660
reversible: true
is described by: ECO:0000000
type: Reaction
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110053#
fast: false
product: MODEL1310110053#
modifier: MODEL1310110053#
is: SBO:0000176
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.2

http://identifiers.org/biomodels.db/MODEL1310110053#_7967b45b_a4fe_43aa_afef_4744791f277f
initial amount: NaN
initial concentration: NaN
name: _NM_013421_1_e
has only substance units: false
is encoded by: hsa:NM 013421
boundary condition: true
is: SBO:0000252
constant: false
type: Species

metaM HC02214 e
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
name: prostaglandin-f1alpha
is: CHEBI:28852
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110053#_e846dca7_bb2a_4c19_8116_8f04817b8e01
initial concentration: NaN
name: UPB1
is: SBO:0000252
constant: false
has only substance units: false
is: B3KNC1
type: Species
boundary condition: true
is encoded by: hsa:51733
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_0a048e6a_d462_497d_855a_c90179dd5394
is encoded by: hsa:170712
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q8TF08
name: COX7B2
type: Species
initial amount: NaN

metaR r2333
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110053#
product: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM alpa hs c
is: CHEBI:52288
name: lysophosphatidic acid
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H6O5PFULLRCO2 CHARGE: -2 INCHI: InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)

metaR GCC2am
modifier: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is: SBO:0000176
name: glycine-cleavage complex (lipoamide), mitochondrial
is version of: http://identifiers.org/ec-code/1.4.4.2
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.4
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.10

metaR UMPK
modifier: MODEL1310110053#
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110053#
name: UMP kinase
is: SBO:0000176
reactant: MODEL1310110053#
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269

metaR PSFLIPm
kinetic law: MODEL1310110053#
reversible: false
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
is described by: ECO:0000269
reactant: MODEL1310110053#
is: SBO:0000185
fast: false
product: MODEL1310110053#
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.6.3.1
type: Reaction
name: phosphatidylserine flippase

metaR ARACHCPT2
reversible: false
modifier: MODEL1310110053#
fast: false
name: carnitine transferase
type: Reaction
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
is: SBO:0000176

metaR H2Otn
is: SBO:0000185
fast: false
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000000
name: H2O transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
type: Reaction
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_f5691b7d_408f_4ed9_958d_c6e71539050d
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:30
is: Q96CA6
name: ACAA1
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_8c3e4973_1730_434d_a367_2fd06bc57224
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:55
name: ACPP
type: Species
is: P15309
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_4572581f_e73e_40e7_9f38_79d0234452d1
initial amount: NaN
has only substance units: false
is: P00568
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:203
boundary condition: true
is: SBO:0000252
name: AK1

metaM HC02213 e
type: Species
is: SBO:0000247
name: prostaglandin-e3
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:28031
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_56d185d8_fa01_4e69_93f3_6f79b0e46f9b
constant: false
is encoded by: hsa:26227
is: SBO:0000252
type: Species
name: PHGDH
initial concentration: NaN
is: O43175
has only substance units: false
initial amount: NaN
boundary condition: true

metaR HMGCOASim
fast: false
reversible: false
reactant: MODEL1310110053#
is described by: ECO:0000269
name: Hydroxymethylglutaryl CoA synthase (ir)
product: MODEL1310110053#
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.3.3.10
type: Reaction
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
kinetic law: MODEL1310110053#
is: SBO:0000176

metaM CE2418 m
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB11123
is: SBO:0000247
boundary condition: false
is: CHEBI:28387
constant: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_e63d8ea4_32bd_458f_b5f5_bbcfb43fd637
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q6I9V5
constant: false
name: SLC25A6
type: Species
is encoded by: hsa:293
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_ff2ad383_47cf_48ed_b55f_68804ff2a9d2
is: Q9H2X9
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:57468
name: SLC12A5
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_917d5348_3e52_461a_90bc_fed86075d0ad
has only substance units: false
is: Q9H3H5
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1798
constant: false
name: DPAGT1

http://identifiers.org/biomodels.db/MODEL1310110053#_e927da87_7cdb_4901_9160_267c8f142f87
is encoded by: hsa:570
is: SBO:0000252
type: Species
constant: false
name: BAAT
initial concentration: NaN
boundary condition: true
is: Q14032
initial amount: NaN
has only substance units: false

metaR r1429
reversible: true
fast: false
product: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
is: SBO:0000185
reactant: MODEL1310110053#
name: Free diffusion
kinetic law: MODEL1310110053#

metaR ACN13ACNGALGBSIDEtg
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reactant: MODEL1310110053#
is described by: ECO:0000000
reversible: true
product: MODEL1310110053#
name: acn13acngalgbside hs intracellular transport
is: SBO:0000185
fast: false
type: Reaction

metaM acgam6p c
boundary condition: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
initial concentration: 1.0
has only substance units: false
name: N-acetyl-D-glucosamine 6-phosphate(2-)
is: SBO:0000247
is: CHEBI:57513
initial amount: NaN
constant: false
type: Species
is: HMDB01062

metaR VD3
name: Vitamin D3 formation
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000134
fast: false
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
reactant: MODEL1310110053#

metaR CYSPHELAT2tc
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Cysteine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR r0993
reversible: false
type: Reaction
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.2
reactant: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14716480,PMID:15209530,PMID:15297262 NOTES:
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_54fd4382_f9fa_4254_be83_837a4ba95bf2
is encoded by: hsa:H17063
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: _H17063_1_m

metaM itaccoa m
type: Species
is: SBO:0000247
is: HMDB03377
name: itaconyl-CoA(5-)
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
is: CHEBI:57381

metaM pi g
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
initial amount: NaN
constant: false
is: HMDB00973
is: CHEBI:43474
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM 3pg c
constant: false
is: http://identifiers.org/pubchem.compound/3497
has only substance units: false
is: C00197
is: SBO:0000247
boundary condition: false
name: 3-Phospho-D-glycerate
is: CHEBI:58272
is: HMDB00807
initial concentration: 1.0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_698cec54_a4c7_4e97_b805_72855c394fbd
is encoded by: hsa:2582
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: Q14376
is: SBO:0000252
boundary condition: true
constant: false
name: GALE

http://identifiers.org/biomodels.db/MODEL1310110053#_2de1d13c_e925_4514_8fe5_461f858edd9f
is: F8WDN9
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: PPA2
is encoded by: hsa:27068
type: Species
constant: false
has only substance units: false
initial amount: NaN

metaM dolp U r
is: CHEBI:57683
is: SBO:0000247
name: dolichyl phosphate(2-)
has only substance units: false
boundary condition: false
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaM glyc3p m
boundary condition: false
has only substance units: false
is: CHEBI:57597
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
constant: false
is: SBO:0000247
is: C00093
initial amount: NaN
is: HMDB00126
initial concentration: 1.0
name: Glycerol 3-phosphate
type: Species

metaR r1428
reversible: true
is: SBO:0000185
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
name: Free diffusion
product: MODEL1310110053#

metaR ORNt3m
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
name: ornithine mitochondrial transport via proton antiport
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true
fast: false

metaR ADK3m
is: SBO:0000176
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.4.10
product: MODEL1310110053#
kinetic law: MODEL1310110053#
name: adentylate kinase (GTP)
type: Reaction
fast: false
modifier: MODEL1310110053#

metaR r2335
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110053#
reversible: true
product: MODEL1310110053#
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000

metaR r0812
modifier: MODEL1310110053#
is: SBO:0000185
product: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
reactant: MODEL1310110053#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
is version of: http://identifiers.org/ec-code/2.3.1.41

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaM hmgcoa m
is: CHEBI:15467
name: Hydroxymethylglutaryl-CoA
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB01375
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356

metaR O2Stm
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
type: Reaction
reactant: MODEL1310110053#
name: superoxide anion transport via diffusion (mitochondria)
reversible: true
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110053#
kinetic law: MODEL1310110053#

metaR CYTK3n
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110053#
reversible: true
name: cytidylate kinase (dCMP,CTP),nuclear
modifier: MODEL1310110053#
is described by: ECO:0000269
kinetic law: MODEL1310110053#
is: SBO:0000176
product: MODEL1310110053#

metaR r0994
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true
name: Facilitated diffusion
kinetic law: MODEL1310110053#
type: Reaction

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaR H2Otp
fast: false
is described by: ECO:0000000
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110053#
reversible: true
name: H2O transport, peroxisomal
type: Reaction
reactant: MODEL1310110053#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110053#_e807cfc5_e45d_49a9_ab9d_57f494ce7974
boundary condition: true
name: ENTPD4
type: Species
is encoded by: hsa:9583
is: Q9Y227
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_aaa7b864_38e0_4a13_ac31_7886710c79c5
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: O95436
name: SLC34A2
initial amount: NaN
is encoded by: hsa:10568
type: Species
constant: false
boundary condition: true

metaR r0780
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110053#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110053#
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
reactant: MODEL1310110053#
fast: false
type: Reaction

metaR HSD3A2r
fast: false
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is version of: http://identifiers.org/ec-code/1.1.1.225
reversible: true
product: MODEL1310110053#
modifier: MODEL1310110053#
is: SBO:0000176

metaR SPHK21c
is version of: http://identifiers.org/ec-code/2.7.1.91
is described by: ECO:0000269
modifier: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
fast: false
kinetic law: MODEL1310110053#
name: sphingosine kinase 2
type: Reaction
reversible: false

metaR PNTK
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.33
type: Reaction
reactant: MODEL1310110053#
is described by: ECO:0000269
name: pantothenate kinase
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_26a60e27_34d6_40ee_8415_94499c4d47bc
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:65010
name: SLC26A6
is: Q9NQU1
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species

metaR L LACt4r
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110053#
is described by: ECO:0000000
name: L-lactate reversible transport via sodium symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
reversible: true
kinetic law: MODEL1310110053#
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_c06a47ee_3938_4d11_98dc_fde8b17aadd2
has part: E5KS60
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8803
initial amount: NaN
constant: false
is: SBO:0000297
type: Species
name: SUCLG1:SUCLA2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_69ea1ed7_4792_47cc_9548_1345202f37a0
type: Species
is: SBO:0000252
boundary condition: true
is: Q9H310
constant: false
has only substance units: false
initial concentration: NaN
name: RHBG
initial amount: NaN
is encoded by: hsa:57127

http://identifiers.org/biomodels.db/MODEL1310110053#_713e4df3_8a89_4de4_8d44_64471d247a05
is encoded by: hsa:55967
boundary condition: true
is: F8VQS7
type: Species
initial concentration: NaN
has only substance units: false
name: NDUFA12
initial amount: NaN
is: SBO:0000252
constant: false

metaR RNDR1
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110053#
name: ribonucleoside-diphosphate reductase (ADP)
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
is: SBO:0000176
reactant: MODEL1310110053#
fast: false
product: MODEL1310110053#
reversible: false
kinetic law: MODEL1310110053#
is described by: ECO:0000254

metaR SERDGLNexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000185
name: D-Serine/Glutamine reversible exchange
reversible: true
product: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
type: Reaction
is described by: ECO:0000304

metaR r0281
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110053#
fast: false
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
is version of: http://identifiers.org/ec-code/5.3.1.6

http://identifiers.org/biomodels.db/MODEL1310110053#_77bec31c_67ee_4bfd_8a41_1d8278536a47
initial amount: NaN
name: ENPP1
type: Species
is encoded by: hsa:5167
is: P22413
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM 3dhguln c
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
name: 3-dehydro-L-gulonate
is: HMDB06334
boundary condition: false
is: CHEBI:57655
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
initial amount: NaN
type: Species

metaR r1632
is described by: ECO:0000000
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110053#
is: SBO:0000185
reactant: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
fast: false

metaR PI4PLC
reactant: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
type: Reaction
fast: false
kinetic law: MODEL1310110053#
is described by: ECO:0000269
reversible: false
name: phosphatidylinositol 4-phosphate phospholipase C
is version of: http://identifiers.org/ec-code/3.1.4.11
is: SBO:0000176
modifier: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_e9090cc2_6089_462e_8395_1cc6c0e05c94
is encoded by: hsa:29929
is: SBO:0000252
has only substance units: false
is: Q9Y672
type: Species
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: ALG6

metaR r1999
fast: false
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110053#
reactant: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
is described by: ECO:0000000

metaM ser L c
has only substance units: false
is: CHEBI:17115
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
name: L-serine
type: Species
is: HMDB00187
is: SBO:0000247
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_b55e169f_770c_4199_8660_86387f1191c5
has only substance units: false
name: GGT2
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:728441
initial amount: NaN
boundary condition: true
type: Species

metaM dtdp c
is: HMDB01274
is: C00363
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:58369
constant: false
is: SBO:0000247
name: dTDP

metaR SARDHm
kinetic law: MODEL1310110053#
is: SBO:0000176
name: Sarcosine dehydrogenase (m)
reversible: false
reactant: MODEL1310110053#
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.5.99.1
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
modifier: MODEL1310110053#

metaR BPNT
is version of: http://identifiers.org/ec-code/3.1.3.7
product: MODEL1310110053#
is described by: ECO:0000269
type: Reaction
fast: false
name: 3',5'-bisphosphate nucleotidase
reversible: false
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
modifier: MODEL1310110053#

metaR r2443
kinetic law: MODEL1310110053#
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110053#
product: MODEL1310110053#

metaR C226COAtx
reversible: true
is described by: ECO:0000000
product: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
reactant: MODEL1310110053#
fast: false
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110053#_ae50a8e4_410c_4732_80d0_eae4bd3cb5cd
is: P48448
is: SBO:0000252
is encoded by: hsa:222
has only substance units: false
type: Species
name: ALDH3B2
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR ACN13ACNGALGBSIDEte
product: MODEL1310110053#
name: acn13acngalgbside hs transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reversible: true
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000185
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_bfd44fdc_80cf_48d4_ac45_b4956c73fee0
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI620219
name: _AI620219_1_c
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN

metaR r2338
fast: false
product: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110053#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
is: SBO:0000185

metaR r1318
is: SBO:0000185
reversible: true
product: MODEL1310110053#
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
type: Reaction
reactant: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
is described by: ECO:0000000

metaR PSSA2 hs
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110053#
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.8.29
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (81490.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylethanolamine version as substrate NJ
name: Phosphatidylserine synthase homo sapiens
fast: false
reversible: true
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_ca59b92c_f22a_46a0_a980_149bab19950d
boundary condition: true
is: SBO:0000252
type: Species
name: SLC22A5
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: O76082
is encoded by: hsa:6584

metaM coa n
is: HMDB01423
type: Species
initial amount: NaN
initial concentration: 1.0
name: coenzyme A(4-)
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_1f40c67d_9589_4dbb_9598_28a798bf85ed
is encoded by: hsa:220
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: ALDH1A3
boundary condition: true
is: P47895
constant: false
type: Species

metaR DOPAt4 2 r
modifier: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Dopamine reversible transport in via sodium symport (1:2)
reversible: true

metaR G14T16g
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false

metaM 34dhmald c
name: 3,4-Dihydroxymandelaldehyde
type: Species
is: http://identifiers.org/pubchem.compound/7903
has only substance units: false
constant: false
is: C05577
is: HMDB06242
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR CYOOm3
fast: false
reversible: false
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.9.3.1
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000134
name: cytochrome c oxidase, mitochondrial Complex IV
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
type: Reaction
is: SBO:0000185
product: MODEL1310110053#

metaR EX dheas LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dehydroepiandrosterone sulfate exchange
type: Reaction

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaR r1633
type: Reaction
fast: false
product: MODEL1310110053#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM dolp U c
is: CHEBI:57683
name: dolichyl phosphate(2-)
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_00381000_18b1_4635_8e3b_0c82156155b3
constant: false
name: _D29675_1_c
initial amount: NaN
is encoded by: hsa:D29675
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN

metaR Coqe
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
product: MODEL1310110053#
reactant: MODEL1310110053#
name: Transport of q10
type: Reaction
reversible: true

metaR r0552
reactant: MODEL1310110053#
fast: false
type: Reaction
product: MODEL1310110053#
reversible: true
is described by: ECO:0000000
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is: SBO:0000176
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.3.5.1
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_83b744de_a19e_4184_aa22_19be76f3d680
has only substance units: false
initial amount: NaN
name: SLC4A8
type: Species
initial concentration: NaN
is encoded by: hsa:9498
is: E7EML0
is: SBO:0000252
constant: false
boundary condition: true

metaM uri c
boundary condition: false
name: Uridine
is: C00299
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00296
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
constant: false
is: CHEBI:16704
has only substance units: false

metaM acgam r
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: HMDB00215
boundary condition: false
name: N-acetyl-D-glucosamine
is: CHEBI:17411
constant: false
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_2610caf4_f620_44cb_bb5c_6378ca67d77a
boundary condition: true
is: Q99798
is: SBO:0000252
initial amount: NaN
constant: false
name: ACO2
is encoded by: hsa:50
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_19eb379f_b507_45af_b2fd_b1f525535377
is encoded by: hsa:51251
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: NT5C3
has only substance units: false
constant: false
is: Q9H0P0
type: Species
boundary condition: true

metaR GGH 5THFe
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110053#
name: Gamma-glutamyl hydrolase (5THF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
is: SBO:0000176
fast: false
reversible: false
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaM HC01410 m
is: CHEBI:28706
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
initial amount: NaN
constant: false
name: (2E)-Hexenoyl-CoA
boundary condition: false
is: SBO:0000247

metaR DNDPt9m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110053#
is described by: ECO:0000269
kinetic law: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000185
name: dADP transport via dTDP antiport
fast: false
reversible: false

metaM arg L e
is: CHEBI:32682
is: HMDB00517
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
has only substance units: false
name: L-argininium(1+)
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_1c5c25e1_fbde_48c5_aada_1e0088550b79
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
boundary condition: true
name: _C7orf24_1_m
is: SBO:0000252
has only substance units: false
is encoded by: hsa:C7orf24

metaM odecoa c
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
is: CHEBI:3793
initial concentration: 1.0
is: HMDB01322
constant: false
boundary condition: false
name: Octadecenoyl-CoA (n-C18:1CoA)
is: SBO:0000247
has only substance units: false

metaR r1634
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110053#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110053#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110053#
type: Reaction
reversible: true

metaM ser L e
is: CHEBI:17115
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00187
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
name: L-serine

metaM HC00250 c
initial amount: NaN
is: CHEBI:29919
type: Species
initial concentration: 1.0
is: SBO:0000247
name: hydrosulfide
constant: false
boundary condition: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
has only substance units: false

metaR S6T5g
kinetic law: MODEL1310110053#
is described by: ECO:0000000
reactant: MODEL1310110053#
reversible: false
type: Reaction
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
product: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaM dtdp e
initial concentration: 1.0
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
type: Species
is: CHEBI:58369
has only substance units: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false

metaR 5ADTSTSTERONESte
fast: false
kinetic law: MODEL1310110053#
name: sulfonated testosterone transport
reversible: true
reactant: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
is described by: ECO:0000000
is: SBO:0000185

metaR r0553
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
product: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
reactant: MODEL1310110053#
reversible: true
fast: false
kinetic law: MODEL1310110053#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110053#_4e3974fc_b71e_420a_86f4_4c28b1f1bfbe
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:H17063
constant: false
has only substance units: false
name: _H17063_1_c
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_b1938264_43d7_4b07_9153_97c139378a0d
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:412
constant: false
is: P08842
type: Species
boundary condition: true
name: STS
initial amount: NaN

metaM coa r
is: C00010
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287
is: HMDB01423
name: Coenzyme A

metaM galgbside hs g
has only substance units: false
is: CHEBI:18259
initial concentration: 1.0
boundary condition: false
name: galactosylgloboside
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
constant: false
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_daba2070_207f_4619_a1a2_de3f4dacb68f
has only substance units: false
name: UPP1
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:7378
initial amount: NaN

metaR RNDR2
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
modifier: MODEL1310110053#
is: SBO:0000176
reactant: MODEL1310110053#
product: MODEL1310110053#
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.17.4.1
name: ribonucleoside-diphosphate reductase (GDP)

metaR CYTDK2m
reactant: MODEL1310110053#
product: MODEL1310110053#
reversible: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
name: cytidine kinase (ATP), mitochondrial
kinetic law: MODEL1310110053#

metaM strdnc c
initial concentration: 1.0
constant: false
is: C16300
is: HMDB06547
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: http://identifiers.org/pubchem.compound/47205608
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: stearidonic acid C18:4, n-3
type: Species
has only substance units: false

metaM HC02213 c
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:28031
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
has only substance units: false
name: prostaglandin-e3

metaM arg L c
type: Species
constant: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00517
name: L-argininium(1+)
boundary condition: false
initial amount: NaN
is: CHEBI:32682

http://identifiers.org/biomodels.db/MODEL1310110053#_ec221d54_ca5b_46f1_87c2_4fbb42c76535
type: Species
is: SBO:0000252
is encoded by: hsa:6582
initial amount: NaN
initial concentration: NaN
constant: false
is: O15244
boundary condition: true
has only substance units: false
name: SLC22A2

metaR r1635
modifier: MODEL1310110053#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110053#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction

metaM ura c
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: Uracil
is: CHEBI:17568
is: HMDB00300
is: C00106
type: Species
has only substance units: false

metaR r0921
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12006583,PMID:1260500,PMID:12838422,PMID:14747464,PMID:16595656,PMID:168203,PMID:17187757,PMID:17279066,PMID:3728675,PMID:6778226,PMID:7419607,PMID:7479738,PMID:8438778 NOTES:
kinetic law: MODEL1310110053#
name: Postulated transport reaction
product: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000185

metaR LEUPHELAT2tc
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaM orn e
is: CHEBI:0
boundary condition: false
is: C01602
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: SBO:0000247
name: Ornithine
has only substance units: false
initial concentration: 1.0
is: HMDB00214
type: Species
constant: false
initial amount: NaN

metaM m7masnB r
initial amount: NaN
type: Species
notes: FORMULA: C64H107N2O50X CHARGE: 0
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
has only substance units: false
is: C05881
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM pchol hs e
boundary condition: false
is: CHEBI:16110
name: Phosphatidylcholine
has only substance units: false
initial amount: NaN
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247

metaR GTHPm
product: MODEL1310110053#
name: glutathione peroxidase, mitochondria
reversible: true
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110053#
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.11.1.15
is version of: http://identifiers.org/ec-code/1.11.1.12
type: Reaction
fast: false
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)

metaR RE2626M
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
product: MODEL1310110053#
name: RE2626
type: Reaction
is: SBO:0000176
reactant: MODEL1310110053#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_5eb3b3b4_22ef_4f17_a7af_5ccf91ad4b37
is encoded by: hsa:AI378339
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
name: _AI378339_1_m
constant: false
is: SBO:0000252

metaM HC00250 e
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
boundary condition: false
has only substance units: false
name: hydrosulfide
type: Species
is: CHEBI:29919
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_7e7972d5_9464_4e3f_a098_65dceec68ccb
constant: false
name: PANK2
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:80025
type: Species
is: Q9BZ23
boundary condition: true

metaM uri e
has only substance units: false
type: Species
is: C00299
name: Uridine
boundary condition: false
initial amount: NaN
is: CHEBI:16704
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00296
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299

http://identifiers.org/biomodels.db/MODEL1310110053#_0e9b4a83_3a1d_4223_a9dd_89c81e7679bf
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is: P24310
initial concentration: NaN
is encoded by: hsa:1346
has only substance units: false
initial amount: NaN
name: COX7A1

metaR UMPK7
reversible: true
fast: false
reactant: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (dGTP)
kinetic law: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM 3pg m
boundary condition: false
constant: false
is: HMDB00807
has only substance units: false
is: CHEBI:58272
initial amount: NaN
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
is: SBO:0000247
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
initial concentration: 1.0
type: Species

metaR r0999
name: Facilitated diffusion
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_82de6cc3_43e1_4883_b6a9_b2652bda10f7
has only substance units: false
initial concentration: NaN
name: TMEM91
is: C9JZ62
is encoded by: hsa:641649
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false

metaR r1636
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_e506b24f_c753_4d55_a95b_2ee526fc95c7
boundary condition: true
initial concentration: NaN
name: UCK1
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: Q5JT09
is encoded by: hsa:83549
is: SBO:0000252

metaR PROSTGD2t
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
modifier: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
fast: false
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_752f88d4_0e29_448e_8a1a_97a6e111e5e5
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:197257
name: LDHD

metaM CE2705 n
is: HMDB02281
is: CHEBI:15374
type: Species
constant: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: quinonoid dihydrobiopterin
initial concentration: 1.0

metaM fe2 c
name: Fe2+
boundary condition: false
is: SBO:0000247
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: C00023
type: Species
is: CHEBI:29033
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00692

metaM strdnc e
type: Species
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: HMDB06547
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
name: stearidonic acid C18:4, n-3
is: http://identifiers.org/pubchem.compound/47205608
has only substance units: false
is: C16300

metaM ksi pre15 g
constant: false
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
name: keratan sulfate I biosynthesis, precursor 15
type: Species
boundary condition: false
is: CHEBI:58053
initial concentration: 1.0
is: HMDB00175
is: C00130
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR RNDR4
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000254
kinetic law: MODEL1310110053#
is: SBO:0000176
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
reactant: MODEL1310110053#
product: MODEL1310110053#
fast: false
reversible: false
type: Reaction
name: ribonucleoside-diphosphate reductase (UDP)

metaR AMETtd
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110053#
is described by: ECO:0000134
product: MODEL1310110053#
reversible: true
is: SBO:0000185
name: diffusion of S-Adenosyl-L-methionine
type: Reaction
reactant: MODEL1310110053#

metaR UMPK5
fast: false
name: UMP kinase (dATP)
kinetic law: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110053#
is: SBO:0000176
reactant: MODEL1310110053#
product: MODEL1310110053#

metaM ksi pre8 g
boundary condition: false
constant: false
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 8
is: SBO:0000247
is: CHEBI:28067
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
initial amount: NaN
type: Species
initial concentration: 1.0

metaR UMPK6
kinetic law: MODEL1310110053#
reversible: true
product: MODEL1310110053#
modifier: MODEL1310110053#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
type: Reaction
reactant: MODEL1310110053#
name: UMP kinase (dCTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176

metaR r1637
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000000
modifier: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction

metaM pchol hs c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
constant: false
is: CHEBI:16110
type: Species
name: Phosphatidylcholine

metaM ksi pre22 g
initial amount: NaN
type: Species
is: HMDB00175
is: SBO:0000247
is: C00130
initial concentration: 1.0
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 22
is: CHEBI:58053
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_0d768cf0_c650_4925_b0c3_41fa209bfc78
is encoded by: hsa:221
has only substance units: false
constant: false
boundary condition: true
type: Species
name: ALDH3B1
initial amount: NaN
is: P43353
initial concentration: NaN
is: SBO:0000252

metaM retinal cis 9 c
boundary condition: false
constant: false
is: CHEBI:17898
is: SBO:0000247
name: all-trans-retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
is: HMDB01358
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_0963de94_49a2_43b3_83ed_82b754f069d9
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:81537
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: SGPP1
type: Species
is: Q9BX95

metaM orn c
boundary condition: false
initial amount: NaN
is: HMDB00214
initial concentration: 1.0
is: C01602
is: CHEBI:0
constant: false
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
name: Ornithine

metaM ura e
has only substance units: false
constant: false
name: uracil
is: CHEBI:17568
initial amount: NaN
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: HMDB00300
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR PAPtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110053#
is described by: ECO:0000000
reversible: false
fast: false
is: SBO:0000185
name: adenosine 3',5'-bisphosphate Golgi transport
kinetic law: MODEL1310110053#
type: Reaction
product: MODEL1310110053#

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_ef92b01e_4c85_48dc_b4c5_60aff968c837
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:51166
is: Q4W5N8
name: AADAT
has only substance units: false
constant: false

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR UMPK4
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reversible: true
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110053#
product: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
name: UMP kinase (GTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR RDH3a
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.300
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
fast: false
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.1.1.105
is: SBO:0000176
type: Reaction
name: retinol dehydrogenase (11-cis,NADPH)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_e4c5f5f4_0c7c_4354_95ce_0e2a2be5163b
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ALDOA
is encoded by: hsa:226
constant: false
type: Species
has only substance units: false
is: P04075
initial amount: NaN

metaR GGH 10FTHF6GLUe
is: SBO:0000176
product: MODEL1310110053#
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000000
fast: false
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
modifier: MODEL1310110053#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_42aa938c_2273_4bf6_9a29_ecf0a67c47e0
is: SBO:0000252
initial concentration: NaN
type: Species
name: PLCG1
has only substance units: false
is encoded by: hsa:5335
boundary condition: true
initial amount: NaN
constant: false
is: P19174

metaR r1916
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
fast: false
type: Reaction
modifier: MODEL1310110053#
reactant: MODEL1310110053#

metaR r1638
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110053#
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_65ea8893_94c2_4d02_bece_f13bb095eddb
initial amount: NaN
type: Species
boundary condition: true
name: FADS2
initial concentration: NaN
constant: false
is: O95864
has only substance units: false
is encoded by: hsa:9415
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_d7c500e5_3065_4337_af7e_a59b603a21e4
name: SDHD
is: SBO:0000252
type: Species
is: O14521
initial concentration: NaN
constant: false
is encoded by: hsa:6392
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_1b7851bc_7edd_4c4d_8cdf_3b5de3aa2a72
name: _X63359_1_c
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:X63359

http://identifiers.org/biomodels.db/MODEL1310110053#_6ddd0f3b_1c6c_4895_a380_2a0efad02b2c
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaM c226coa m
constant: false
is: http://identifiers.org/pubchem.compound/47205479
initial amount: NaN
is: C16169
boundary condition: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: SBO:0000247
type: Species
name: cervonyl coenzyme A
initial concentration: 1.0
has only substance units: false

metaR UMPK3
reactant: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
modifier: MODEL1310110053#
name: UMP kinase (UTP)
is described by: ECO:0000269
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000176

metaR TREHe
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
is described by: ECO:0000269
name: alpha,alpha-trehalase
kinetic law: MODEL1310110053#
reversible: false
is: SBO:0000176
product: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.2.1.28
fast: false

metaM ksi pre26 g
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
is: CHEBI:28067
constant: false
type: Species
is: SBO:0000247
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 26
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR EX paf hs LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
type: Reaction

metaM fe2 e
initial concentration: 1.0
is: HMDB00692
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:29033
name: Fe2+
initial amount: NaN
constant: false
is: C00023
type: Species
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023

http://identifiers.org/biomodels.db/MODEL1310110053#_dd11e559_57a1_4881_8de0_966340ceb5b8
initial concentration: NaN
is encoded by: hsa:2182
is: SBO:0000252
has only substance units: false
is: Q5JWV8
name: ACSL4
boundary condition: true
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_08ca17be_b0c1_452d_b38c_8ceffdfc632e
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: _AI090874_1_c
is encoded by: hsa:AI090874

metaR r1639
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110053#
product: MODEL1310110053#
modifier: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110053#

metaM pser L c
name: O-Phospho-L-serine
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15811
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB01721
type: Species

metaM glyc3p c
initial amount: NaN
is: HMDB00126
boundary condition: false
initial concentration: 1.0
is: CHEBI:57597
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: C00093
name: Glycerol 3-phosphate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_1bb29de5_b3d4_4a74_ad12_f067f6ad4339
is: SBO:0000252
boundary condition: true
is: P36269
is encoded by: hsa:2687
has only substance units: false
constant: false
name: GGT5
initial amount: NaN
type: Species
initial concentration: NaN

metaR r1998
reversible: false
is: SBO:0000185
modifier: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110053#
fast: false
is described by: ECO:0000000

metaR r1784
reversible: false
reactant: MODEL1310110053#
product: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_af0e53f8_638f_4ca9_b7b3_a86cb360c76e
is: Q16836
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
name: HADH
boundary condition: true
is encoded by: hsa:3033
constant: false

metaR r0149
type: Reaction
product: MODEL1310110053#
modifier: MODEL1310110053#
reversible: true
reactant: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is described by: ECO:0000000
is: SBO:0000176
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/1.14.13.39
kinetic law: MODEL1310110053#

metaM h e
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/3380
constant: false
is: CHEBI:24636
name: proton
initial amount: NaN
boundary condition: false
is: C00080
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: "

metaM pi r
is: HMDB00973
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
name: hydrogenphosphate
initial concentration: 1.0
constant: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: C00009
is: CHEBI:43474

metaR r1651
product: MODEL1310110053#
reversible: true
fast: false
reactant: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110053#
is: SBO:0000185
kinetic law: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r1994
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110053#
modifier: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: false
is: SBO:0000185

metaM glyc3p x
has only substance units: false
is: HMDB00126
is: CHEBI:57597
constant: false
boundary condition: false
name: Glycerol 3-phosphate
initial amount: NaN
type: Species
is: C00093
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: SBO:0000247
initial concentration: 1.0

metaR FACOAL1832
is: SBO:0000176
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110053#
product: MODEL1310110053#
fast: false
is described by: ECO:0000269
name: fatty-acid--CoA ligase
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE3114C

metaM malcoa e
type: Species
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: CHEBI:57384
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: malonyl-CoA(4-)
is: HMDB01175
boundary condition: false

metaM glc D e
has only substance units: false
type: Species
name: D-glucose
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
constant: false
is: CHEBI:4167
is: HMDB00122
is: SBO:0000247

metaR D3AIBTm
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
kinetic law: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
reactant: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
type: Reaction
fast: false
is: SBO:0000176

metaM xtsn c
has only substance units: false
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
is: HMDB00299
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: xanthosine
boundary condition: false
is: CHEBI:18107

metaR VITD3t2
fast: false
reversible: false
kinetic law: MODEL1310110053#
is described by: ECO:0000000
reactant: MODEL1310110053#
product: MODEL1310110053#
name: Vitamin D3 uptake
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT

metaR ASPTA
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110053#
kinetic law: MODEL1310110053#
name: aspartate transaminase
type: Reaction
fast: false
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaM glc D c
is: CHEBI:4167
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
initial amount: NaN
type: Species
is: HMDB00122
initial concentration: 1.0

metaM gtp c
type: Species
is: HMDB01273
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: C00044
initial concentration: 1.0
constant: false
is: CHEBI:37565
has only substance units: false
name: GTP

metaR EX malcoa LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: malonyl-CoA(4-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_c9601dce_4390_4f0b_b500_5d5024e5c5ba
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: IDH1
boundary condition: true
is encoded by: hsa:3417
is: O75874
has only substance units: false
type: Species

metaM gua c
is: C00242
constant: false
name: Guanine
is: HMDB00132
has only substance units: false
type: Species
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:16235
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_0ceb7acd_c90f_49f3_8d97_8273b79133f4
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
name: FDFT1
is encoded by: hsa:2222
initial concentration: NaN
has only substance units: false
is: P37268
constant: false

metaM m4mpdol U r
type: Species
is: SBO:0000247
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: CHEBI:37633

metaR FAOXC1811603m
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
is described by: ECO:0000269
reversible: false
name: Beta oxidation fatty acid
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false

metaR r1650
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110053#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110053#
is: SBO:0000185

metaM arg L m
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
name: L-argininium(1+)
is: CHEBI:32682
boundary condition: false
is: HMDB00517
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
constant: false
initial concentration: 1.0

metaM srtn e
is: HMDB00259
has only substance units: false
name: serotonin(1+)
initial amount: NaN
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
type: Species
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:350546
initial concentration: 1.0

metaM dtdp m
is: HMDB01274
type: Species
initial concentration: 1.0
name: dTDP
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
has only substance units: false
constant: false
is: C00363
is: CHEBI:58369
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR DNDPt29m
reversible: false
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
reactant: MODEL1310110053#
product: MODEL1310110053#
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
is: SBO:0000185
name: dCDP transport via dADP antiport

metaM HC01412 m
is: SBO:0000247
is: CHEBI:61405
boundary condition: false
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: trans-tetradec-2-enoyl-CoA(4-)
initial concentration: 1.0
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273

metaR ANTHte
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of anthranilate
fast: false
reactant: MODEL1310110053#
type: Reaction
reversible: true
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110053#

metaM h c
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3380
name: proton
is: CHEBI:24636
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: "
boundary condition: false
is: C00080
type: Species

metaR S6TASE1ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110053#

metaM 56dthm c
initial concentration: 1.0
has only substance units: false
is: HMDB00079
is: CHEBI:27468
type: Species
constant: false
name: 5,6-dihydrothymine
boundary condition: false
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
initial amount: NaN
is: SBO:0000247

metaM nh4 c
is: CHEBI:28938
boundary condition: false
name: Ammonium
constant: false
initial concentration: 1.0
is: C01342
is: HMDB00051
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_6f362451_9515_4752_9422_82c6ae437d46
initial amount: NaN
initial concentration: NaN
name: ADSS
has only substance units: false
is encoded by: hsa:159
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is: P30520

metaR NRPPHRtu
fast: false
type: Reaction
name: Norepinephrine uniport
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110053#
product: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

metaR NH4t3r
is: SBO:0000185
name: ammonia transport via proton antiport
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
is described by: ECO:0000269
reversible: true
product: MODEL1310110053#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_64f6c9d4_8fd2_44ce_9c66_c19d24c0c1b9
is encoded by: hsa:27068
name: PPA2
initial amount: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_85fe5f60_3db9_4788_9cc7_30c10a7470fd
constant: false
name: GK2
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2712
is: Q14410
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_7042b724_98e1_4de2_9f07_5a8a59ec14a7
type: Species
is: SBO:0000252
name: ENTPD8
boundary condition: true
is: Q5MY95
initial amount: NaN
constant: false
is encoded by: hsa:377841
has only substance units: false
initial concentration: NaN

metaR r0345
reactant: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.99.13

http://identifiers.org/biomodels.db/MODEL1310110053#_e466b35d_6ba0_4e10_aaa5_b30bfaa875f1
is: SBO:0000252
name: ST6GALNAC2
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:10610
is: Q9UJ37
type: Species
initial concentration: NaN
initial amount: NaN

metaM tsul m
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: SBO:0000247
boundary condition: false
is: CHEBI:16094
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: thiosulfate(2-)
constant: false
is: HMDB00257

metaM andrstrn c
constant: false
is: CHEBI:16032
name: androsterone
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00031

metaM strdnccoa m
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205473
boundary condition: false
name: stearidonyl coenzyme A
is: SBO:0000247
is: HMDB06519
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
initial concentration: 1.0
is: C16163
type: Species

metaR ACNMLr
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 4.1.3.3 Confidence Level: 2 AUTHORS: NOTES:JLR
is: SBO:0000176
kinetic law: MODEL1310110053#
product: MODEL1310110053#
fast: false
reversible: true
reactant: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
name: N-Acetylneuraminate lyase (reversible)

metaR MDHm
is version of: http://identifiers.org/ec-code/1.1.1.37
type: Reaction
reversible: true
modifier: MODEL1310110053#
is described by: ECO:0000134
product: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
reactant: MODEL1310110053#
is: SBO:0000176
fast: false
name: malate dehydrogenase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110053#_1277724e_ae9a_4b50_9311_f313644db96c
boundary condition: true
name: ATP10A
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:57194
initial amount: NaN
is: O60312
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_e05bd6de_6581_4d83_893f_4044a5d870fe
constant: false
boundary condition: true
name: ALDH1A3
initial concentration: NaN
is encoded by: hsa:220
type: Species
is: SBO:0000252
is: P47895
initial amount: NaN
has only substance units: false

metaR RE1709N
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110053#
fast: false
name: RE1709
modifier: MODEL1310110053#
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/4.2.1.96
reactant: MODEL1310110053#

metaR r0559
reactant: MODEL1310110053#
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.5.1.3
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
fast: false
product: MODEL1310110053#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110053#

metaR HEX1
is described by: ECO:0000134
name: hexokinase (D-glucose:ATP)
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.1
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.2
reactant: MODEL1310110053#
is: SBO:0000176
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
fast: false
reversible: false
product: MODEL1310110053#

metaR r0870
reversible: true
is described by: ECO:0000000
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.7.7.72
product: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.6.1.1
is version of: http://identifiers.org/ec-code/3.6.4.13
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.1.3.4
type: Reaction
fast: false
reactant: MODEL1310110053#

metaM CE5854 e
is: HMDB02710
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:27485
initial amount: NaN
has only substance units: false
name: gama-CEHC-glucuronide
constant: false
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
is: SBO:0000247

metaR DHCRD1
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000269
name: dihydroceramide desaturase
product: MODEL1310110053#
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110053#

metaR G14T4g
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110053#
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaM xol27oh m
boundary condition: false
is: HMDB02103
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
initial concentration: 1.0
is: CHEBI:17703
constant: false
name: 26-hydroxycholesterol

http://identifiers.org/biomodels.db/MODEL1310110053#_e3685198_ce37_4f6f_ae78_4776cf1f1d05
boundary condition: true
is encoded by: hsa:AI926493
constant: false
name: _AI926493_1_c
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM gua e
is: HMDB00132
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:16235
name: guanine
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR r1991
modifier: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110053#
is: SBO:0000185
product: MODEL1310110053#
name: Y+LAT2 Utilized transport

metaR UMPK2
kinetic law: MODEL1310110053#
product: MODEL1310110053#
modifier: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
name: UMP kinase (CTP)
reactant: MODEL1310110053#
fast: false
is: SBO:0000176

metaM srtn c
type: Species
is: HMDB00259
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: serotonin(1+)
is: CHEBI:350546
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
initial concentration: 1.0
boundary condition: false

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaR BDMT U
is described by: ECO:0000000
reactant: MODEL1310110053#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110053#
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.142
kinetic law: MODEL1310110053#
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110053#_96303dfd_91f4_40ab_999c_a4f338c97de6
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:4846
is: A0S0A7
initial amount: NaN
has only substance units: false
name: NOS3
is: SBO:0000252

metaM methf m
initial concentration: 1.0
is: CHEBI:57455
is: HMDB01354
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
constant: false
boundary condition: false
name: (6R)-5,10-methenyltetrahydrofolate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_aacdd393_6472_44a9_af23_7400d302d409
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is: P49247
initial concentration: NaN
boundary condition: true
is encoded by: hsa:22934
name: RPIA
initial amount: NaN

metaM odecoa m
is: HMDB01322
type: Species
is: CHEBI:57387
name: Octadecenoyl-CoA (n-C18:1CoA)
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
constant: false
initial amount: NaN

metaR NAGLCAly
type: Reaction
reversible: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000176
name: N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
is described by: ECO:0000000
fast: false

metaR r1655
product: MODEL1310110053#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110053#_591f6671_f0f4_4571_8546_2cd6055b4f05
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
name: GGT1
is encoded by: hsa:2678

metaR GULNter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110053#
is described by: ECO:0000000
fast: false
product: MODEL1310110053#
reversible: false
name: L-gulonate endoplasmic reticular export
reactant: MODEL1310110053#

metaR r0558
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
fast: false
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
product: MODEL1310110053#
reversible: true
reactant: MODEL1310110053#

metaM 3dsphgn c
has only substance units: false
is: HMDB01480
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
constant: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58299

http://identifiers.org/biomodels.db/MODEL1310110053#_3566471c_ebbe_4eab_a381_a02f1e1c0818
is: Q86SF2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: GALNT7
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:51809
type: Species

metaR RE2079R
kinetic law: MODEL1310110053#
reversible: true
name: RE2079
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:

metaM nh4 e
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00051
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:28938
name: ammonium
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaM leuktrC4 c
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB01198
initial concentration: 1.0
is: CHEBI:57973
name: leukotriene C4(2-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_f5d8ba7d_b8da_49e7_9a79_37023c623e9b
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
name: AKR1A1
is encoded by: hsa:10327
constant: false
is: P14550
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_838e06c7_ca4a_41c0_ad10_f1596cb8fa2d
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
name: GMPS
is: P49915
boundary condition: true
initial amount: NaN
is encoded by: hsa:8833
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_276e3471_4e0f_4cab_a67b_5ae00b2e1edf
initial concentration: NaN
is encoded by: hsa:6818
name: SULT1A3
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_47f465df_7a22_4283_9955_e033dfa1250c
is encoded by: hsa:1103
is: Q6LEN6
constant: false
has only substance units: false
initial concentration: NaN
name: CHAT
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_4cedf813_47d2_4529_90f6_67f842289403
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaR GLYC3Ptmc
name: glycerol-3-phopshate transport, cytoplasm
reversible: true
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000134
is: SBO:0000185
fast: false
product: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: added during gap filling. No evidence found for such a reaction. NOTES:added during gap filling. No evidence found for such a reaction.

metaM prostge1 e
is: CHEBI:57397
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB01442
initial amount: NaN
name: prostaglandin E1(1-)
boundary condition: false
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741

metaR r1654
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110053#
product: MODEL1310110053#
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110053#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_ab636f60_d986_48bd_be9f_77c9df659969
name: _BE042354_1_m
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:BE042354
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252

metaM lpam m
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
boundary condition: false
has only substance units: false
is: HMDB00962
name: lipoamide
initial concentration: 1.0
is: CHEBI:17460

metaR AG13T5g
product: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110053#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110053#

metaM dag hs c
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
type: Species
has only substance units: false
is: CHEBI:18035
boundary condition: false
name: diglyceride
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM gal c
is: HMDB00143
is: CHEBI:0
is: SBO:0000247
boundary condition: false
is: C00124
has only substance units: false
initial amount: NaN
constant: false
name: D-Galactose
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0
initial concentration: 1.0

metaM dd2coa m
constant: false
is: HMDB03712
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
name: trans-dodec-2-enoyl-CoA(4-)
is: CHEBI:57330
is: SBO:0000247

metaM ksii core2 pre10 g
initial concentration: 1.0
type: Species
name: keratan sulfate II biosynthesis, precursor 10
is: CHEBI:28067
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR IDOAASE1ly
name: alpha-L-iduronidase, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.76
is: SBO:0000176
type: Reaction
reactant: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110053#_e00a891d_ff03_4557_a324_6ef296c6e837
is encoded by: hsa:8818
initial amount: NaN
is encoded by: hsa:8813
boundary condition: true
has only substance units: false
has part: Q86TM7
initial concentration: NaN
type: Species
has part: O94777
constant: false
has part: O60762
is: SBO:0000297
name: DPM3:DPM1:DPM2
is encoded by: hsa:54344

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaM 13 cis retn r
boundary condition: false
constant: false
is: HMDB06219
name: 13-cis-retinoate
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7847414
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: D00348
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952

metaM 3hmbcoa m
initial amount: NaN
is: HMDB01356
constant: false
has only substance units: false
type: Species
is: CHEBI:57312
initial concentration: 1.0
is: SBO:0000247
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
boundary condition: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405

metaR ASCBOX
fast: false
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000176
reversible: false
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: ascorbic acid oxidase
type: Reaction
is described by: ECO:0000000

metaR RE1525M
product: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
name: RE1525
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

metaR RE0926E
is version of: http://identifiers.org/ec-code/3.2.1.17
name: RE0926
reversible: true
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
product: MODEL1310110053#
is: SBO:0000176
kinetic law: MODEL1310110053#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.1
modifier: MODEL1310110053#
is described by: ECO:0000000
type: Reaction

metaM paf hs e
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:36707
type: Species
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
is: SBO:0000247
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_0eae66f6_d3f2_499d_b0f1_9df581a3e158
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: PPCS
initial amount: NaN
is encoded by: hsa:79717
constant: false
is: Q9HAB8
boundary condition: true

metaR r1653
fast: false
reactant: MODEL1310110053#
product: MODEL1310110053#
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0556
is version of: http://identifiers.org/ec-code/1.14.19.1
reactant: MODEL1310110053#
is described by: ECO:0000000
type: Reaction
fast: false
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110053#_888c61a6_e47a_4a7b_8625_f7678fa55499
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
is: Q549M5
has only substance units: false
name: NDUFC2
constant: false
is encoded by: hsa:4718
initial concentration: NaN

metaR Ser Thrtg
is: SBO:0000185
type: Reaction
name: Ser/Thr transport (from golgi to lysosome)
product: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:

metaR CHOLD2m
is described by: ECO:0000269
modifier: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.1.99.1
fast: false
name: choline dehydrogenase (FAD acceptor), mitochondrial
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110053#
reversible: false
notes: GENE_ASSOCIATION: (55349.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.99.1 Confidence Level: 4 AUTHORS: PMID:15321791 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110053#_7caa6f95_56fb_4ebc_ab1b_de2137018e42
name: SLC2A14
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:144195
is: SBO:0000252
has only substance units: false
is: Q8TDB8
type: Species

metaM malcoa c
is: SBO:0000247
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: HMDB01175
initial concentration: 1.0
is: C00083
initial amount: NaN
boundary condition: false
is: CHEBI:57384
type: Species
has only substance units: false
constant: false
name: Malonyl-CoA

metaR EX andrstrn LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Androsterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_1029c01c_1b35_4979_b031_6f2b506cb045
type: Species
is encoded by: hsa:56894
initial amount: NaN
constant: false
is: Q9NRZ7
initial concentration: NaN
name: AGPAT3
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR r1396
is: SBO:0000176
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
name: EC:2.3.1.21
reactant: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false

metaR TYRTA
kinetic law: MODEL1310110053#
name: tyrosine transaminase
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
modifier: MODEL1310110053#
is: SBO:0000176
reversible: true
reactant: MODEL1310110053#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.1
type: Reaction
product: MODEL1310110053#

metaM ksii core2 pre5 g
is: CHEBI:58053
notes: FORMULA: C61H99N5O43X CHARGE: -1
constant: false
boundary condition: false
has only substance units: false
is: C00130
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 5
initial concentration: 1.0
is: HMDB00175
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_41c766ba_54cb_4988_9284_6f2045771ba6
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is: O43772
name: SLC25A20
type: Species
initial amount: NaN
is encoded by: hsa:788
constant: false

metaR M13N2Tg
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.101
fast: false
reversible: false
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
is: SBO:0000176
type: Reaction
product: MODEL1310110053#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

metaR r1652
product: MODEL1310110053#
modifier: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_4e90b6b0_b4f8_463a_8c7a_f5cd8325bf2d
has only substance units: false
name: PAH
initial amount: NaN
constant: false
is: P00439
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:5053
is: SBO:0000252

metaM dag hs e
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
name: diglyceride
type: Species
is: CHEBI:18035
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_8c82f302_b7eb_4f33_a04e_8fe7a82daa02
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2720
initial amount: NaN
is: P16278
type: Species
boundary condition: true
name: GLB1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_5e34065e_839d_4873_8d7b_80351c102f17
type: Species
constant: false
boundary condition: true
is encoded by: hsa:55902
initial amount: NaN
name: ACSS2
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q5QPH3

metaM c226coa c
has only substance units: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
name: cervonyl coenzyme A
type: Species
is: C16169
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205479
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_e1e98bd7_cd77_4b7e_b203_52d54a9c6071
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:3633
is: P32019
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: INPP5B

metaM gal e
type: Species
is: CHEBI:0
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0
name: D-Galactose
initial amount: NaN
boundary condition: false
is: C00124
constant: false
is: HMDB00143
has only substance units: false

metaR EX glyb LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycine betaine exchange
type: Reaction

metaM dctp n
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: SBO:0000247
is: C00458
is: HMDB00998
is: CHEBI:16311
has only substance units: false
boundary condition: false
type: Species
constant: false
name: dCTP

metaM paf hs c
has only substance units: false
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
is: CHEBI:36707
type: Species
initial amount: NaN
is: SBO:0000247

metaM prostge1 c
is: HMDB01442
type: Species
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:57397
boundary condition: false
name: prostaglandin E1(1-)
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741

http://identifiers.org/biomodels.db/MODEL1310110053#_34344656_629e_4c1a_a93b_280debeed16e
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
name: _7359_1_c
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:7359

metaR NODe
kinetic law: MODEL1310110053#
type: Reaction
is: SBO:0000185
is described by: ECO:0000134
fast: false
reversible: true
reactant: MODEL1310110053#
name: NODe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110053#

metaR r2059
fast: false
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM 5oxpro e
type: Species
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
is: SBO:0000247
constant: false
is: HMDB00267
name: 5-oxoprolinate
initial concentration: 1.0
is: CHEBI:57606
boundary condition: false
has only substance units: false
initial amount: NaN

metaR r0990
is: SBO:0000185
kinetic law: MODEL1310110053#
name: Postulated transport reaction
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
fast: false
reactant: MODEL1310110053#

metaM tym c
boundary condition: false
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:327995
name: tyraminium
is: SBO:0000247
constant: false
is: HMDB00306
type: Species

metaR TYMSULT
kinetic law: MODEL1310110053#
is described by: ECO:0000269
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.1
reversible: false
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
name: Tyramine Sulfotransferase
product: MODEL1310110053#
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_034182c5_8e5e_4883_a849_f719c5ec28c3
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q5SPY7
name: ENTPD2
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:954

http://identifiers.org/biomodels.db/MODEL1310110053#_2c2eb1da_454e_4868_b44f_7fa23e1c28d9
initial amount: NaN
boundary condition: true
name: _AI601100_1_m
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI601100
is: SBO:0000252
type: Species
constant: false

metaR G12MT2 U
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
reversible: false
type: Reaction
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110053#_f338ff18_5c64_4494_9b8e_8fe62d0945f1
boundary condition: true
constant: false
is: E9PCI1
is: SBO:0000252
name: ACP2
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:53

metaR r0340
type: Reaction
reversible: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.38
kinetic law: MODEL1310110053#
product: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
reactant: MODEL1310110053#

metaM gtp m
is: HMDB01273
boundary condition: false
constant: false
name: GTP
initial concentration: 1.0
type: Species
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: CHEBI:37565
is: C00044
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaM mag hs e
constant: false
is: SBO:0000247
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
name: monoacylglycerol 2
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB03073
has only substance units: false
is: CHEBI:32391
type: Species

metaM 56dthm m
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:27468
constant: false
initial amount: NaN
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
name: 5,6-dihydrothymine
initial concentration: 1.0
is: HMDB00079
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_b1fc435d_92d5_4129_b71c_8d4bc3508f2b
name: HAS1
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:3036
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q8IYH3
initial amount: NaN

metaM gdpddman c
initial concentration: 1.0
type: Species
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222
initial amount: NaN
is: HMDB01346
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:57964
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_b718f788_2d55_47e9_9174_00e860236d9e
name: SLC26A7
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:115111
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_0a590719_0ccc_4e37_9407_debb7c0c268b
is encoded by: hsa:10723
type: Species
has only substance units: false
constant: false
boundary condition: true
name: SLC12A7
is: Q9Y666
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM h m
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
type: Species
is: CHEBI:24636
is: C00080
initial concentration: 1.0
name: proton
has only substance units: false

metaR r1546
kinetic law: MODEL1310110053#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_078ce4b8_f034_4490_8f3a_6495ef9fc786
constant: false
name: ACP1
is encoded by: hsa:52
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: Q59EH3

http://identifiers.org/biomodels.db/MODEL1310110053#_b484cfee_a089_41d2_9551_6036ae39d9a9
is: Q53G02
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
name: DAD1
is encoded by: hsa:1603

metaR AG13T15g
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110053#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110053#
fast: false

metaM strdnccoa c
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
boundary condition: false
has only substance units: false
constant: false
is: C16163
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB06519
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205473
name: stearidonyl coenzyme A

metaR r0142
reactant: MODEL1310110053#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110053#
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
fast: false
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
type: Reaction
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.5

metaM cmpacna g
has only substance units: false
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: CHEBI:57812
initial concentration: 1.0
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: HMDB01176
is: SBO:0000247
name: CMP-N-acetyl-beta-neuraminate(2-)

metaR RE1709C
product: MODEL1310110053#
name: RE1709
reactant: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110053#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110053#_d160b2bd_b12a_428b_a088_7413bcd9576f
name: CDS2
boundary condition: true
type: Species
is: O95674
has only substance units: false
is encoded by: hsa:8760
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN

metaM 5adtststerone e
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
name: 17beta-hydroxy-5alpha-androstan-3-one
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: HMDB02961
is: CHEBI:16330

metaM hs deg3 l
initial amount: NaN
is: SBO:0000247
is: CHEBI:16126
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
boundary condition: false
name: heparan sulfate, degradation product 3
initial concentration: 1.0
constant: false
has only substance units: false
type: Species

metaR r0829
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/4.1.1.37
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is described by: ECO:0000000
product: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
is: SBO:0000185

metaM tsul c
is: SBO:0000247
is: CHEBI:16094
initial amount: NaN
type: Species
constant: false
is: HMDB00257
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
name: thiosulfate(2-)
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_ffd1632a_dd50_4d57_be3b_3b0cb19e36c5
is: SBO:0000252
initial amount: NaN
is: P42765
boundary condition: true
initial concentration: NaN
type: Species
name: ACAA2
has only substance units: false
constant: false
is encoded by: hsa:10449

metaR GLCURtly
modifier: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110053#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
name: glucuronate transport into lysososme
reactant: MODEL1310110053#
fast: false

metaM crm hs r
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
name: N-acylsphingosine
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial concentration: 1.0
is: CHEBI:52639
constant: false
boundary condition: false

metaM h n
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:24636
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
has only substance units: false
is: SBO:0000247
constant: false

metaR HISTAtu
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000185
reactant: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
name: Histamine uniport
fast: false
is described by: ECO:0000269
modifier: MODEL1310110053#
type: Reaction

metaM 5oxpro c
initial amount: NaN
type: Species
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
name: 5-oxoprolinate
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:57606
boundary condition: false
is: HMDB00267

http://identifiers.org/biomodels.db/MODEL1310110053#_cf19fac0_e089_4cc4_b584_c61a89506645
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is: P04745
is encoded by: hsa:277
initial amount: NaN
name: AMY1B

metaR PMANM
kinetic law: MODEL1310110053#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/5.4.2.8
is version of: http://identifiers.org/ec-code/5.4.2.2
product: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110053#
is: SBO:0000176
modifier: MODEL1310110053#
name: phosphomannomutase
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

metaR NDP8
is: SBO:0000176
type: Reaction
fast: false
name: nucleoside-diphosphatase (dUDP)
reactant: MODEL1310110053#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.4.9
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110053#
is described by: ECO:0000269
modifier: MODEL1310110053#

metaR GLCNACT U
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110053#
fast: false
reversible: false
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (uterus)
type: Reaction
reactant: MODEL1310110053#

metaR LEUt5m
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
name: leucine mitochondrial transport

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaM leuktrC4 e
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB01198
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: CHEBI:57973
name: leukotriene C4(2-)
initial concentration: 1.0

metaR r0879
reversible: false
fast: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110053#
is: SBO:0000185
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1

metaR CERT2gt
name: ceramide transport protein
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
reversible: true
kinetic law: MODEL1310110053#
is: SBO:0000185
modifier: MODEL1310110053#
product: MODEL1310110053#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_c997de11_96cf_45d4_97b4_b8b08995940e
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:AI934540
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: _AI934540_1_c
boundary condition: true

metaR r1544
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110053#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110053#
product: MODEL1310110053#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR GGH 10FTHF5GLUe
is version of: http://identifiers.org/ec-code/3.4.19.9
reversible: false
modifier: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
kinetic law: MODEL1310110053#
is described by: ECO:0000000
reactant: MODEL1310110053#
product: MODEL1310110053#
fast: false
type: Reaction

metaM 5adtststerone c
name: 17beta-hydroxy-5alpha-androstan-3-one
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB02961
initial amount: NaN
constant: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial concentration: 1.0
boundary condition: false
is: CHEBI:16330

metaM 1pyr5c m
initial concentration: 1.0
type: Species
is: C03912
is: HMDB01301
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:15893
constant: false
name: 1-Pyrroline-5-carboxylate

http://identifiers.org/biomodels.db/MODEL1310110053#_75a82b64_2cb6_4f6b_b2b0_d4e79988e788
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: PTGIS
constant: false
type: Species
is: Q16647
initial concentration: NaN
is encoded by: hsa:5740

http://identifiers.org/biomodels.db/MODEL1310110053#_b1a5f681_9fac_47a9_9d24_06a75a1e5c22
is encoded by: hsa:80724
type: Species
constant: false
boundary condition: true
has only substance units: false
is: G3XAJ0
is: SBO:0000252
name: ACAD10
initial concentration: NaN
initial amount: NaN

metaM nh4 m
type: Species
name: Ammonium
is: CHEBI:28938
has only substance units: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: C01342
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00051
initial concentration: 1.0
boundary condition: false

metaM mpdol U c
constant: false
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
has only substance units: false
is: CHEBI:18396
type: Species
notes: FORMULA: C1245H2040N20O220P20 CHARGE: -20
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_2bbb7196_6d1a_4794_8e79_1f42ee7a2db6
constant: false
is: Q9BZQ4
is: SBO:0000252
boundary condition: true
has only substance units: false
name: NMNAT2
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:23057

metaR r0450
type: Reaction
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
is described by: ECO:0000000
is: SBO:0000176
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
reactant: MODEL1310110053#
product: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.3

metaM 5dhf e
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB06487
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
has only substance units: false
name: pentaglutamyl folate (DHF)
type: Species
constant: false

metaM nadp r
is: SBO:0000247
has only substance units: false
is: CHEBI:58349
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: C00006
initial concentration: 1.0
is: HMDB00217
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate

metaM h l
is: C00080
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:24636
name: proton
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: "
is: http://identifiers.org/pubchem.compound/3380

metaR r1423
reactant: MODEL1310110053#
fast: false
type: Reaction
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000000
name: Facilitated diffusion
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:

metaR RE0512M
type: Reaction
name: RE0512
reversible: true
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
product: MODEL1310110053#
is: SBO:0000176
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110053#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false

metaR A4GALTg
modifier: MODEL1310110053#
type: Reaction
name: Lactosylceramide 4-alpha-galactosyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.228
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
kinetic law: MODEL1310110053#
is: SBO:0000176
reversible: false
product: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
is described by: ECO:0000269

metaM tsul e
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00257
type: Species
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
name: thiosulfate(2-)
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:16094

metaM pi n
initial concentration: 1.0
is: HMDB00973
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
is: CHEBI:43474

metaM nh4 n
is: CHEBI:28938
initial amount: NaN
has only substance units: false
name: ammonium
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
type: Species
is: HMDB00051
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_59a8d50d_e19e_4644_a3ef_f46e1270b525
type: Species
name: ALG3
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:10195
has only substance units: false
is: SBO:0000252
constant: false

metaR FE3MTP1
name: transport of ferrous iron into blood
is described by: ECO:0000134
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
fast: false
reversible: false
kinetic law: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
is: SBO:0000185
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_981c9cdb_1b76_4ff3_8237_bc3de85ea165
constant: false
is: P21953
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: BCKDHB
is encoded by: hsa:594
type: Species
boundary condition: true

metaM mi14p c
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00968
is: CHEBI:58282
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
is: SBO:0000247
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate

metaR UMPK6n
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
reversible: true
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
is described by: ECO:0000269
name: UMP kinase (dCTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110053#
is: SBO:0000176

metaR DRIBt
name: deoxyribose transport via diffusion
is: SBO:0000185
product: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110053#_d9a80e3c_4fb8_4e32_a823_de1191c1668d
has only substance units: false
name: SLC13A4
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:26266
constant: false
type: Species
is: Q9UKG4

metaM but e
is: HMDB00039
type: Species
initial concentration: 1.0
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
name: butyrate
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17968

metaM nadp m
is: CHEBI:58349
is: C00006
is: SBO:0000247
has only substance units: false
constant: false
name: Nicotinamide adenine dinucleotide phosphate
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: HMDB00217

metaR FAOXC226205m
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110053#
modifier: MODEL1310110053#
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.3.8.1

metaR RE0569E
type: Reaction
name: RE0569
is: SBO:0000176
product: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (4017.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_9066a3e7_c7a4_4c32_941d_46332a79197b
is: SBO:0000252
name: AUH
is encoded by: hsa:549
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is: Q13825
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_db0a847a_c035_499c_b553_092c7d03df63
initial concentration: NaN
is: A4D0W4
has only substance units: false
name: AASS
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:10157
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_4717c0f7_2e1a_4394_94cf_3b0c98e3a4ac
constant: false
is: SBO:0000252
is encoded by: hsa:AV717590
name: _AV717590_1_c
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_9194c750_bf25_431d_b683_aa36ef26800f
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ENTPD1
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: Q86VV3
is encoded by: hsa:953

http://identifiers.org/biomodels.db/MODEL1310110053#_e67eb2fc_519c_4e68_878b_25de7c1e85c6
is: Q16831
is: SBO:0000252
is encoded by: hsa:7378
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: UPP1
has only substance units: false

metaR HS1ly
type: Reaction
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000000
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
name: heparan-N-sulfatase, lysosomal
product: MODEL1310110053#
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.10.1.1

metaR r0145
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.3.1
type: Reaction
reactant: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_96a37186_701b_4b51_9fae_9a82874bcee6
is: Q9NR34
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:57134
name: MAN1C1
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_d599a2e5_c388_4ca1_a572_e1d19146ac7b
is encoded by: hsa:6319
type: Species
has only substance units: false
initial amount: NaN
is: O00767
boundary condition: true
name: SCD
is: SBO:0000252
initial concentration: NaN
constant: false

metaM Asn X Ser Thr r
constant: false
initial concentration: 1.0
boundary condition: false
name: protein-linked asparagine residue (N-glycosylation site)
type: Species
has only substance units: false
notes: FORMULA: XH CHARGE: 0
initial amount: NaN
is: HMDB00051
is: C01342
is: CHEBI:28938
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_719002c4_6d58_4e13_85c1_b66fb9e87e79
type: Species
is: Q9ULD0
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: OGDHL
constant: false
initial amount: NaN
is encoded by: hsa:55753

metaM cmpacna c
type: Species
is: CHEBI:57812
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
name: CMP-N-acetyl-beta-neuraminate(2-)
is: HMDB01176
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR CYSGLYexR
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
product: MODEL1310110053#
name: L-cysteine/glycine reversible exchanger

metaM g2m8masn r
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: C05874
notes: FORMULA: C82H137N2O65X CHARGE: 0
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

http://identifiers.org/biomodels.db/MODEL1310110053#_a0ce54c5_443f_447a_a24d_3ee202507f2a
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: _AI971036_1_c
is encoded by: hsa:AI971036

http://identifiers.org/biomodels.db/MODEL1310110053#_279cb6a1_1ac2_4d95_a457_a86f1f456c8f
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI373818
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
name: _AI373818_1_m

http://identifiers.org/biomodels.db/MODEL1310110053#_5fd2ad5f_f700_46d1_b280_64e384804384
has only substance units: false
is: Q9NPH0
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:51205
name: ACP6
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_92723061_1567_479e_927a_e420cb21a0b4
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:205
constant: false
has only substance units: false
is: P27144
name: AK4
boundary condition: true
type: Species
is: SBO:0000252

metaR r0456
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
is version of: http://identifiers.org/ec-code/2.7.1.32
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
reactant: MODEL1310110053#
product: MODEL1310110053#

metaM imp c
is: SBO:0000247
type: Species
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: C00130
initial concentration: 1.0
name: IMP
boundary condition: false
constant: false
is: CHEBI:58053
initial amount: NaN
has only substance units: false
is: HMDB00175

metaR PVD3
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
type: Reaction
is: SBO:0000176
product: MODEL1310110053#
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110053#
name: Previtamin D3 formation
kinetic law: MODEL1310110053#
fast: false

metaM 2oxoadp m
name: 2-oxoadipate(2-)
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:57499
initial concentration: 1.0
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: HMDB00225

metaM gal l
is: HMDB00143
initial concentration: 1.0
name: D-galactose
is: SBO:0000247
initial amount: NaN
is: CHEBI:12936
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
boundary condition: false
has only substance units: false
constant: false

metaR CDS
notes: GENE_ASSOCIATION: (1040.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:ER membrane - but on cytosolic surface NJ
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.7.41
fast: false
name: phosphatidate cytidylyltransferase
is: SBO:0000176
modifier: MODEL1310110053#
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110053#
product: MODEL1310110053#

metaR DPCOAK
type: Reaction
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.3
kinetic law: MODEL1310110053#
is described by: ECO:0000269
product: MODEL1310110053#
is: SBO:0000176
reactant: MODEL1310110053#
name: dephospho-CoA kinase
modifier: MODEL1310110053#
fast: false

metaM HC01434 m
initial amount: NaN
type: Species
is: SBO:0000247
name: oxalatosuccinate(3-)
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial concentration: 1.0
is: CHEBI:58931

metaR r1540
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
type: Reaction
reversible: false
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
is version of: http://identifiers.org/ec-code/1.17.4.1
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110053#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_0a9181a1_ce3e_4db9_bdea_1dd87c77bb0e
has only substance units: false
is encoded by: hsa:AV713053
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: _AV713053_1_m
type: Species
is: SBO:0000252
constant: false

metaR r0669
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: false
product: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000176
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17

metaM h g
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:24636
name: proton
has only substance units: false
initial amount: NaN

metaM but c
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
type: Species
is: HMDB00039
name: butyrate
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:17968
initial amount: NaN

metaR MTRI
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 5.3.1.23 Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:
reversible: true
fast: false
reactant: MODEL1310110053#
name: 5-methylthioribose-1-phosphate isomerase
is described by: ECO:0000000
kinetic law: MODEL1310110053#
is: SBO:0000176
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_4da3d28d_55f0_4842_9013_cea3267164f7
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:6576
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: D9HTE9
name: SLC25A1

metaM m4mpdol U c
is: CHEBI:37633
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false

metaM gtp n
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:37565
is: HMDB01273
initial concentration: 1.0
constant: false
name: GTP(4-)
type: Species
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaM pi m
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:43474
type: Species
is: HMDB00973
is: C00009
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate

metaM ksi pre28 g
is: SBO:0000247
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 28
has only substance units: false
is: CHEBI:58053
is: HMDB00175
is: C00130
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C213H341N15O176S8X CHARGE: -9

metaR 2OXOADOXm
is: SBO:0000176
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.4.2
is version of: http://identifiers.org/ec-code/1.8.1.4
is described by: ECO:0000304
product: MODEL1310110053#
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.61
modifier: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB

metaR G14T10g
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
modifier: MODEL1310110053#
reversible: false
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90

metaR UNK2
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110053#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110053#
kinetic law: MODEL1310110053#
name: 2-keto-4-methylthiobutyrate transamination
reversible: false

metaR MTHFD2m
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
modifier: MODEL1310110053#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
is described by: ECO:0000254
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.9
reactant: MODEL1310110053#

metaR BUP2
name: beta-ureidopropionase (D-3-amino-isobutanoate forming)
modifier: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:11508704,PMID:5773299 NOTES:MM
reversible: false
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.5.1.6
is: SBO:0000176
fast: false
kinetic law: MODEL1310110053#
type: Reaction
is described by: ECO:0000269

metaR CHATn
modifier: MODEL1310110053#
name: Choline O-acetyltransferase
reactant: MODEL1310110053#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.6
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
type: Reaction
is described by: ECO:0000269
fast: false
product: MODEL1310110053#
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_796bf068_8172_41c2_bc62_a92eb7c3b12e
type: Species
name: NAGA
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is: P17050
initial amount: NaN
boundary condition: true
is encoded by: hsa:4668

metaR r0668
type: Reaction
fast: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
modifier: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.19
reversible: true
is described by: ECO:0000000

metaM pacald c
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
initial amount: NaN
has only substance units: false
name: phenylacetaldehyde
is: HMDB06236
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:16424
type: Species
initial concentration: 1.0

metaR r1299
name: Vesicular transport
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
fast: false
kinetic law: MODEL1310110053#
is: SBO:0000185

metaR CYTK1n
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reversible: true
reactant: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP),nuclear
type: Reaction

metaR r2344
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110053#
is: SBO:0000185
reversible: true
name: Organic anion transporter 5 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110053#
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_6a26af68_ffac_4260_9be7_0d1206798d10
is: SBO:0000252
has only substance units: false
is: Q5JZF5
type: Species
is encoded by: hsa:212
initial concentration: NaN
name: ALAS2
constant: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_72b2973e_c93c_44db_9133_5a2063987fad
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:79017
type: Species
name: GGCT
constant: false
is: B8ZZR8
initial concentration: NaN

metaM 3m4hpga c
initial amount: NaN
constant: false
is: HMDB04061
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
boundary condition: false
is: SBO:0000247
is: C05583
initial concentration: 1.0
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
is: http://identifiers.org/pubchem.compound/7909
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_599881f4_78a1_49a7_bc90_e21da9ce584a
type: Species
is encoded by: hsa:10400
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
name: PEMT
is: SBO:0000252
initial concentration: NaN

metaR r0670
product: MODEL1310110053#
is: SBO:0000176
kinetic law: MODEL1310110053#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110053#

metaR r0074
reactant: MODEL1310110053#
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
kinetic law: MODEL1310110053#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.1
modifier: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110053#
type: Reaction

metaR UDPGALtg
modifier: MODEL1310110053#
is described by: ECO:0000269
fast: false
reversible: true
product: MODEL1310110053#
name: UDP-Gal Golgi transport via CMP antiport
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000185
type: Reaction

metaR DURIK1
fast: false
type: Reaction
reactant: MODEL1310110053#
is: SBO:0000176
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:
name: deoxyuridine kinase (ATP:Deoxyuridine)
product: MODEL1310110053#
reversible: false
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.1.21
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110053#_45160d9d_ee74_49ef_8dbb_0ea5a06d042a
is encoded by: hsa:AI222095
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: _AI222095_1_e
constant: false
type: Species

metaR CYTK1m
is: SBO:0000176
kinetic law: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
fast: false
name: cytidylate kinase (CMP),mitochondrial
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_3992b47e_4f07_49de_80c3_713ef78342ea
initial amount: NaN
boundary condition: true
type: Species
name: DLST
constant: false
is: SBO:0000252
is: P36957
is encoded by: hsa:1743
initial concentration: NaN
has only substance units: false

metaR 3MOX4HOXPGALDOX NADP
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
type: Reaction
is: SBO:0000176
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
product: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000304
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase
kinetic law: MODEL1310110053#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_2eb2736e_c3da_431e_9b1f_0668b34da4bc
is: P00338
constant: false
type: Species
is: SBO:0000252
has only substance units: false
name: LDHA
boundary condition: true
initial amount: NaN
is encoded by: hsa:3939
initial concentration: NaN

metaM for c
initial amount: NaN
is: HMDB00142
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:15740
name: Formate
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
constant: false
has only substance units: false
is: SBO:0000247
is: C00058

metaR DALAt2r
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000185
product: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
reversible: true
is described by: ECO:0000304
name: D-alanine transport via proton symport
fast: false
type: Reaction

metaR DIGALSGALSIDEtg
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
product: MODEL1310110053#
is: SBO:0000185
reversible: true
type: Reaction
name: digalsgalside hs intracellular transport
reactant: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#

metaR DIGALSIDEtg
reversible: true
type: Reaction
product: MODEL1310110053#
is: SBO:0000185
reactant: MODEL1310110053#
name: digalside hs intracellular transport
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
kinetic law: MODEL1310110053#

metaR B MANNASEly
fast: false
product: MODEL1310110053#
is: SBO:0000176
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
reversible: false
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.2.1.25
type: Reaction
name: beta-mannosidase, lysosomal
is described by: ECO:0000000
modifier: MODEL1310110053#

metaR ARABR
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.21
modifier: MODEL1310110053#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.2
name: arabinose reductase
product: MODEL1310110053#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110053#_82fc95e0_23ce_478f_9205_6d1d7ae4064c
constant: false
is: SBO:0000252
initial concentration: NaN
name: ALDH3A1
boundary condition: true
has only substance units: false
is encoded by: hsa:218
initial amount: NaN
is: P30838
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_d549d46a_1815_4675_ae50_5a83b5ee01bf
is encoded by: hsa:2879
has only substance units: false
is: P36969
name: GPX4
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN

metaR r2396
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
is: SBO:0000185
fast: false
reactant: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
kinetic law: MODEL1310110053#
is described by: ECO:0000000

metaM cl c
is: C00115
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:3966
constant: false
boundary condition: false
is: HMDB00492
is: SBO:0000247
notes: FORMULA: Cl CHARGE: -1
name: Chloride

metaR r2343
type: Reaction
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110053#
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
product: MODEL1310110053#
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_ab078bfd_0e45_4423_91f6_4560297261f6
is: SBO:0000252
name: _U37519_1_e
constant: false
initial concentration: NaN
is encoded by: hsa:U37519
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_3576a1e7_bbf0_4557_9af8_4b4180dc2118
name: ACSL3
type: Species
initial amount: NaN
is: O95573
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2181

metaR r1298
is described by: ECO:0000000
kinetic law: MODEL1310110053#
reversible: false
product: MODEL1310110053#
is: SBO:0000185
reactant: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
name: Vesicular transport

http://identifiers.org/biomodels.db/MODEL1310110053#_76d581cb_34a8_4714_b0d5_093429526fef
is: SBO:0000252
name: HADHB
initial concentration: NaN
constant: false
has only substance units: false
is: P55084
boundary condition: true
is encoded by: hsa:3032
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_4eb6c3fb_7f1a_4965_8d2e_09c67f0e2270
name: ALG3
type: Species
has only substance units: false
is: Q92685
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:10195
boundary condition: true

metaR TXA2te
kinetic law: MODEL1310110053#
fast: false
type: Reaction
name: thromboxane A2 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tc -> TXA2te to get to EC space NJ
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110053#
product: MODEL1310110053#

metaM maltttr e
is: SBO:0000247
type: Species
name: Maltotetraose
is: HMDB01296
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: C02052
constant: false
is: http://identifiers.org/pubchem.compound/5141
initial amount: NaN
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052

http://identifiers.org/biomodels.db/MODEL1310110053#_8b9cda98_637b_45bb_9452_e417b6e6ae59
constant: false
is encoded by: hsa:6567
is: P36021
is: SBO:0000252
name: SLC16A2
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR EX coa LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for coa
type: Reaction

metaM b2coa m
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB02009
initial amount: NaN
has only substance units: false
is: CHEBI:57332
name: crotonoyl-CoA(4-)
type: Species
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
boundary condition: false

metaR CYTK13n
is described by: ECO:0000269
modifier: MODEL1310110053#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is: SBO:0000176
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110053#
reversible: true
name: cytidylate kinase (dCMP,dATP),nuclear

http://identifiers.org/biomodels.db/MODEL1310110053#_937597a8_0ea8_4e10_acd2_5ea55dedffd8
type: Species
constant: false
name: DOLPP1
is: Q86YN1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:57171
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_3c6d3391_7ef9_4216_9a7a_bd043ffcd4d5
boundary condition: true
is encoded by: hsa:57379
constant: false
name: AICDA
is: Q546Y9
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

metaM saccrp L m
constant: false
notes: FORMULA: C11H19N2O6 CHARGE: -1 INCHI: InChI=1S/C11H20N2O6/c12-7(10(16)17)3-1-2-6-13-8(11(18)19)4-5-9(14)15/h7-8,13H,1-6,12H2,(H,14,15)(H,16,17)(H,18,19)/p-1/t7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00363
is: HMDB00279
is: CHEBI:57951
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: L-saccharopinate(1-)
initial amount: NaN

metaM f1a l
notes: FORMULA: C22H37N2O15X CHARGE: 0
name: F1alpha
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB02917
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: CHEBI:17151

metaM clpn hs c
name: clpn_hs[c]
is: HMDB02704
initial amount: NaN
type: Species
notes: FORMULA: CHARGE: 0
constant: false
is: CHEBI:21338
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaR r0983
kinetic law: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110053#
fast: false
name: solute carrier family 27 (fatty acid transporter), member 5 TCDB:4.C.1.1.5 TCDB:4.C.1.1.8
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reactant: MODEL1310110053#

metaM crm hs g
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: N-acylsphingosine
constant: false
is: CHEBI:52639

metaR MANter
is: SBO:0000185
type: Reaction
product: MODEL1310110053#
name: mannose efflux from endoplasmic reticulum
kinetic law: MODEL1310110053#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000
reactant: MODEL1310110053#

metaM dlnlcgcoa c
initial concentration: 1.0
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
constant: false
is: CHEBI:27979
has only substance units: false
type: Species
is: SBO:0000247
name: dihomo-gamma-linolenyl coenzyme A
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_eb90b30f_97a5_4d42_8d2a_66bfa14837ff
has only substance units: false
boundary condition: true
is encoded by: hsa:6818
is: P50224
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
name: SULT1A3

metaM drib c
has only substance units: false
is: CHEBI:28816
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
constant: false
initial concentration: 1.0
name: 2-deoxy-D-ribose
is: HMDB03224
initial amount: NaN
type: Species

metaM lthstrl r
is: HMDB01170
initial concentration: 1.0
constant: false
is: CHEBI:17168
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
type: Species
name: 5alpha-cholest-7-en-3beta-ol
has only substance units: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_846a3d8a_7afe_4f40_983f_3260a3dc526e
is encoded by: hsa:956
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: ENTPD3
is: O75355
boundary condition: true

metaR CYTK2n
product: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reversible: true
name: cytidylate kinase (dCMP),nuclear
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM xan c
is: HMDB00292
name: Xanthine
boundary condition: false
initial amount: NaN
is: CHEBI:17712
constant: false
is: C00385
is: SBO:0000247
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
has only substance units: false
initial concentration: 1.0
type: Species

metaM dctp c
is: HMDB00998
is: CHEBI:16311
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: C00458
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
name: dCTP
is: SBO:0000247

metaR r1418
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000176

metaR PROSTGE1t
modifier: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
reversible: true
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
fast: false
is: SBO:0000185
kinetic law: MODEL1310110053#
is described by: ECO:0000269
reactant: MODEL1310110053#

metaR r0984
is: SBO:0000185
product: MODEL1310110053#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110053#
fast: false
name: solute carrier family 27 (fatty acid transporter), member 5 TCDB:4.C.1.1.5 TCDB:4.C.1.1.8
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110053#

metaM stcoa m
type: Species
initial concentration: 1.0
constant: false
name: Stearoyl-CoA (n-C18:0CoA)
is: C00412
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:57394
is: HMDB01114
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_ccaa46fd_ff82_4e8e_a541_d9f2b72ae27c
is: SBO:0000252
name: MTHFD1L
is encoded by: hsa:25902
is: B2RD24
constant: false
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN

metaR PGI
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/5.3.1.9
type: Reaction
product: MODEL1310110053#
name: glucose-6-phosphate isomerase
kinetic law: MODEL1310110053#
is: SBO:0000176
modifier: MODEL1310110053#
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
fast: false

metaM rib D e
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:16988
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
type: Species
has only substance units: false
name: D-ribose
is: HMDB00283
initial amount: NaN
initial concentration: 1.0

metaM andrstrn r
type: Species
is: SBO:0000247
name: androsterone
boundary condition: false
is: HMDB00031
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16032
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
has only substance units: false

metaR NDPK1m
type: Reaction
is described by: ECO:0000254
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is: SBO:0000176
reactant: MODEL1310110053#

metaR ACGAMtly
fast: false
reactant: MODEL1310110053#
reversible: false
product: MODEL1310110053#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
is: SBO:0000185
type: Reaction
name: N-acetyl-glucosamine lysosomal efflux
kinetic law: MODEL1310110053#

metaM cl e
is: SBO:0000247
is: CHEBI:3966
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: C00115
type: Species
name: Chloride
notes: FORMULA: Cl CHARGE: -1
constant: false
has only substance units: false
is: HMDB00492

metaR r2341
is described by: ECO:0000000
reactant: MODEL1310110053#
name: Organic anion transporter 5 Utilized transport
type: Reaction
kinetic law: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110053#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110053#_2d21338d_8766_44a4_a729_6b871fa1e01f
name: B3GALT5
is encoded by: hsa:10317
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species

metaR RE0915E
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.17
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
fast: false
product: MODEL1310110053#
reversible: true
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.2.1.1
name: RE0915

http://identifiers.org/biomodels.db/MODEL1310110053#_834e730a_8d29_459d_bb95_d9d995e8bfef
initial amount: NaN
boundary condition: true
is encoded by: hsa:55907
is: Q8NFW8
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: CMAS

http://identifiers.org/biomodels.db/MODEL1310110053#_1d71e6ab_0ee8_4e1f_b2b5_4a8d55697368
type: Species
has only substance units: false
initial amount: NaN
name: _U52111_1_c
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:U52111

http://identifiers.org/biomodels.db/MODEL1310110053#_40b62f42_a27d_4031_a971_303b3144ce30
is: O76062
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:7108
initial amount: NaN
boundary condition: true
name: TM7SF2
initial concentration: NaN
has only substance units: false

metaM CE5236 c
boundary condition: false
initial concentration: 1.0
is: HMDB03952
has only substance units: false
constant: false
type: Species
is: SBO:0000247
name: O2'-4a-cyclic-tetrahydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
initial amount: NaN
is: CHEBI:28002

metaR ECOAH12m
kinetic law: MODEL1310110053#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
modifier: MODEL1310110053#
fast: false
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110053#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110053#

metaM drib e
constant: false
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
name: 2-deoxy-D-ribose
is: HMDB03224
initial concentration: 1.0
is: CHEBI:28816

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaM HC01609 e
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
initial concentration: 1.0
constant: false
name: UroporphyrinogenI
type: Species
is: CHEBI:28766
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM h r
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:24636
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: C00080
type: Species
name: proton

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

metaM hs deg15 l
name: heparan sulfate, degradation product 15
is: CHEBI:16126
type: Species
initial amount: NaN
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247

metaR NADHtru
name: NADH transporter, endoplasmic reticulum
product: MODEL1310110053#
is: SBO:0000185
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
kinetic law: MODEL1310110053#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false

metaM rib D c
initial amount: NaN
is: SBO:0000247
constant: false
name: D-ribose
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
initial concentration: 1.0
is: CHEBI:16988
is: HMDB00283
boundary condition: false
type: Species

metaM gdpmann c
name: GDP-alpha-D-mannose(2-)
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
initial amount: NaN
type: Species
is: CHEBI:57527
is: HMDB01163

http://identifiers.org/biomodels.db/MODEL1310110053#_21db619e_b2c9_41e0_9b52_4c8c1bf257f7
has only substance units: false
is: SBO:0000252
name: RRM2B
is encoded by: hsa:50484
initial amount: NaN
is: Q7LG56
boundary condition: true
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_dc4ae8a5_790e_457c_820a_c46943749431
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: SLC23A2
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:9962

metaR PUNP4
kinetic law: MODEL1310110053#
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Deoxyguanosine)
modifier: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
type: Reaction
reversible: true
reactant: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1

metaR r1538
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000185
fast: false
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110053#
reversible: false
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:

metaR r2347
reversible: true
product: MODEL1310110053#
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110053#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110053#
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110053#_e8e1a88a_a5b6_4d62_869e_ff1b869900b9
is: Q674R7
boundary condition: true
has only substance units: false
initial concentration: NaN
name: ATG9B
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:285973

metaR G14T15g
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
type: Reaction
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
product: MODEL1310110053#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_d8063a31_6535_4f96_86ad_a20986f7924f
boundary condition: true
is encoded by: hsa:284129
is: SBO:0000252
constant: false
is: Q86WA9
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
name: SLC26A11

metaR CYSSNAT5tc
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR PA HSter
reversible: true
type: Reaction
reactant: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
is: SBO:0000185
name: phosphatidate scramblase
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
fast: false

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_3c17c885_25fb_499d_b2fb_479bfe65e3a6
initial concentration: NaN
has only substance units: false
is: A6NFM2
is: SBO:0000252
type: Species
constant: false
name: PYCR1
boundary condition: true
initial amount: NaN
is encoded by: hsa:5831

metaR HAS2
fast: false
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.212
kinetic law: MODEL1310110053#
reversible: false
name: hyaluronan synthase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
type: Reaction
modifier: MODEL1310110053#
is: SBO:0000185
reactant: MODEL1310110053#

metaM icit c
initial amount: NaN
is: HMDB00193
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
name: Isocitrate
is: CHEBI:16087
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: C00311

metaR LEUGLYPEPT1tc
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_884f5de8_c5aa_4554_b1f0_9c2d64e905f6
is encoded by: hsa:171425
constant: false
is: Q8N0X4
initial amount: NaN
type: Species
name: CLYBL
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR r2346
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110053#
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110053#
type: Reaction
fast: false

metaR PUNP7
kinetic law: MODEL1310110053#
fast: false
product: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
is: SBO:0000176
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Xanthosine)
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110053#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_3adeac68_8f0a_44b0_abbe_0cb892848998
is encoded by: hsa:8050
has part: P09622
initial amount: NaN
initial concentration: NaN
is: SBO:0000297
constant: false
is encoded by: hsa:4967
has only substance units: false
boundary condition: true
type: Species
has part: Q02218
has part: O00330
has part: P36957
is encoded by: hsa:1738
is encoded by: hsa:1743
name: DLD:DLST:OGDH:PDHX

metaR GUAt
reactant: MODEL1310110053#
is described by: ECO:0000269
product: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
fast: false
name: Guanine transport
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_8f03cf88_0442_4a74_8144_8f4a74d94034
is: P00390
is encoded by: hsa:2936
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
name: GSR
type: Species

metaM crm hs c
type: Species
boundary condition: false
is: SBO:0000247
name: N-acylsphingosine
constant: false
is: CHEBI:52639
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial amount: NaN

metaM ksi pre9 g
constant: false
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 9
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00175
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
is: C00130
is: CHEBI:58053
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_3421d1f3_382c_49c6_a619_00e3b67156fd
constant: false
has only substance units: false
name: ABCD1
type: Species
initial amount: NaN
boundary condition: true
is: P33897
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:215

metaR LEUKTRD4t
product: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
name: leukotriene D4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_675318ac_3e88_4bf2_9c7b_905e96d807e1
initial amount: NaN
boundary condition: true
is: Q96CA6
name: ACAA1
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:30
is: SBO:0000252
has only substance units: false

metaM pe hs m
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:16038
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
is: SBO:0000247
type: Species
name: phosphatidylethanolamine
initial amount: NaN

metaR SUCCt2m
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reactant: MODEL1310110053#
is described by: ECO:0000269
product: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#
is: SBO:0000185
name: succinate transport, mitochondrial
fast: false
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_12aae639_25c9_4b63_b835_bc66e6390758
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q6LEN6
boundary condition: true
type: Species
is encoded by: hsa:1103
initial amount: NaN
constant: false
name: CHAT

http://identifiers.org/biomodels.db/MODEL1310110053#_ce46d507_8e19_443f_94f8_010ee190b127
initial amount: NaN
type: Species
initial concentration: NaN
is: Q15392
name: DHCR24
is encoded by: hsa:1718
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true

metaR UDPDOLPT U
kinetic law: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
is described by: ECO:0000000
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (uterus)
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:10359825,PMID:8280060 NOTES:NCD
is: SBO:0000176
fast: false
reactant: MODEL1310110053#
reversible: false
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.117

http://identifiers.org/biomodels.db/MODEL1310110053#_2108180c_59cb_48e7_b008_2984ae327ce8
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
type: Species
name: NDUFA13
is encoded by: hsa:51079
is: Q9P0J0

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_f75f5d8e_0cae_4b02_9a62_dbb7d5f54a93
has part: P22392
has part: P15531
is encoded by: hsa:4830
is encoded by: hsa:4831
boundary condition: true
name: NME1:NME2
is: SBO:0000297
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_79a0dc03_401f_4c2a_9564_4558d1dcd6b6
initial amount: NaN
is encoded by: hsa:11182
initial concentration: NaN
type: Species
has only substance units: false
name: SLC2A6
constant: false
boundary condition: true
is: Q9UGQ3
is: SBO:0000252

metaR FAOXC180
modifier: MODEL1310110053#
is described by: ECO:0000269
product: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
kinetic law: MODEL1310110053#
type: Reaction
name: Beta oxidation of long chain fatty acid
reversible: false
fast: false
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110053#_d2ee96ce_f16b_4b48_a2f4_48ceaa7988a1
type: Species
boundary condition: true
is: Q8TE04
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:53354
initial amount: NaN
name: PANK1

metaM 2dr1p c
is: HMDB01351
is: C00672
name: 2-Deoxy-D-ribose 1-phosphate
has only substance units: false
is: CHEBI:58576
is: SBO:0000247
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
boundary condition: false

metaR r1397
is: SBO:0000176
product: MODEL1310110053#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
name: carnitine acetyltransferase EC:2.3.1.7
kinetic law: MODEL1310110053#
fast: false

metaR SBTR
reactant: MODEL1310110053#
product: MODEL1310110053#
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.1.1.21
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
reversible: false
kinetic law: MODEL1310110053#
fast: false
type: Reaction
is: SBO:0000176
name: D-sorbitol reductase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.2

metaR r1291
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000185
reactant: MODEL1310110053#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
fast: false
name: Postulated transport reaction

metaR r0295
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
reversible: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110053#
reactant: MODEL1310110053#
fast: false

metaR DESAT18 10
is: SBO:0000176
reactant: MODEL1310110053#
name: fatty acyl-CoA desaturase (n-C18:2CoA -> n-C18:3CoA)
reversible: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#

metaM HC01496 m
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
name: 2-Amino-3-oxoadipate
is: CHEBI:28095
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_14939645_b676_4cda_8c8b_f1677af61e81
is: SBO:0000252
is encoded by: hsa:6391
initial concentration: NaN
name: SDHC
type: Species
boundary condition: true
has only substance units: false
is: Q99643
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_bed9ba6b_0055_4677_9cc0_bcac7160191d
is: SBO:0000252
is: P09622
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:1738
has only substance units: false
name: DLD
boundary condition: true

metaR PROSTGF2t
type: Reaction
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
name: prostaglandin uniport
reversible: true
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
product: MODEL1310110053#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110053#
is: SBO:0000185

metaR HEX7
name: hexokinase (D-fructose:ATP)
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.1.2
reversible: false
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
is version of: http://identifiers.org/ec-code/2.7.1.1
type: Reaction
kinetic law: MODEL1310110053#
is: SBO:0000176
product: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
modifier: MODEL1310110053#

metaM HC01603 c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57454
constant: false
name: 10-Formyltetrahydrofolate
has only substance units: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: SBO:0000247
type: Species
is: C00234

http://identifiers.org/biomodels.db/MODEL1310110053#_5b056155_9dc8_4267_be87_566e11059a53
is: B3KTV4
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:122622
constant: false
type: Species
name: ADSSL1
is: SBO:0000252

metaR r1646
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
reversible: true
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110053#

metaM cbasp e
initial concentration: 1.0
boundary condition: false
is: C00438
has only substance units: false
name: N-Carbamoyl-L-aspartate
type: Species
initial amount: NaN
is: HMDB00828
notes: FORMULA: C5H6N2O5 CHARGE: -2
is: CHEBI:32814
constant: false
is: SBO:0000247

metaR DAGK hs
reactant: MODEL1310110053#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110053#
name: Diacylglycerol phosphate kinase (homo sapiens)
kinetic law: MODEL1310110053#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.107
product: MODEL1310110053#
type: Reaction
is described by: ECO:0000269

metaM CE0849 m
type: Species
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
constant: false
has only substance units: false
initial amount: NaN
name: cis,cis-palmito-7,10-dienoyl-CoA
is: C01936
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_e4b5ecd9_9570_44d5_be1e_f4bd39149bf7
has only substance units: false
constant: false
initial concentration: NaN
name: HAS3
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:3038
is: O00219
type: Species

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_e18d06ef_e382_4df1_bb6a_459edfaef362
constant: false
boundary condition: true
name: GALNT10
is: Q86SR1
has only substance units: false
is encoded by: hsa:55568
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_cfb90e79_8bf7_4229_876b_b3487701f2ad
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:BE966236
initial concentration: NaN
name: _BE966236_1_c
constant: false
is: SBO:0000252
initial amount: NaN

metaM retn r
constant: false
name: all-trans-retinoate
type: Species
is: CHEBI:35291
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01852
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777

http://identifiers.org/biomodels.db/MODEL1310110053#_ed1a24a2_af2a_42c3_87ce_403947cf1948
type: Species
name: PAFAH1B1
is encoded by: hsa:5048
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: P43034
initial amount: NaN

metaR 3AIB Dtm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:
reversible: true
reactant: MODEL1310110053#
fast: false
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000134
name: transport of 3aib_D into mitochondria

metaM stcoa c
is: C00412
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:57394
is: HMDB01114
name: Stearoyl-CoA (n-C18:0CoA)
constant: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_1b44cfb7_d3ef_40d0_b930_68f7d94385a5
has only substance units: false
type: Species
is: Q9BQG2
initial amount: NaN
initial concentration: NaN
name: NUDT12
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:83594

http://identifiers.org/biomodels.db/MODEL1310110053#_f20d8777_1640_40e6_ab4f_1e85446aa48b
initial amount: NaN
name: QDPR
has only substance units: false
is encoded by: hsa:5860
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: P09417
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_610f0508_0bcf_4fa5_8096_c746cc9d6854
initial amount: NaN
name: NDUFA4L2
is: Q9NRX3
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:56901
has only substance units: false
type: Species

metaR IDOURte
type: Reaction
reactant: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
name: L-iduronate transport, extracellular
is: SBO:0000185
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110053#

metaR GLCNACPT U
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (uterus)
is version of: http://identifiers.org/ec-code/2.7.8.15
is: SBO:0000176
modifier: MODEL1310110053#
fast: false
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_8db0ff8a_395f_49b5_a6a9_a64c74046b22
is: SBO:0000252
name: GGT7
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:2686
is: A0PJJ9
type: Species
boundary condition: true

metaR r1647
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
fast: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_39c6e9c2_c9e5_43c8_a371_efcf6db21a28
initial amount: NaN
initial concentration: NaN
is: Q86YU0
boundary condition: true
has only substance units: false
is: SBO:0000252
name: CA7
type: Species
is encoded by: hsa:766
constant: false

metaR GGH 6DHFe
fast: false
is described by: ECO:0000000
modifier: MODEL1310110053#
product: MODEL1310110053#
name: Gamma-glutamyl hydrolase (6DHF), extracellular
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110053#_7fcbc8f8_770d_4bb4_8920_a736c20652cd
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5313
type: Species
name: PKLR
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is: P30613

metaM 3mox4hoxm c
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
name: 3-Methoxy-4-hydroxymandelate
is: HMDB00291
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
constant: false
is: CHEBI:27622

metaR EX cholate LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholate
type: Reaction

metaR GLCAASE9ly
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.31
reactant: MODEL1310110053#
name: beta-glucuronidase, lysosomal
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reversible: false
modifier: MODEL1310110053#
type: Reaction

metaR PUNP3
modifier: MODEL1310110053#
reactant: MODEL1310110053#
name: purine-nucleoside phosphorylase (Guanosine)
type: Reaction
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1

metaR r0932
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
is: SBO:0000185
fast: false
reversible: true
name: Transport reaction

metaR r1644
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true
type: Reaction
reactant: MODEL1310110053#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110053#_ef79bb92_977e_4569_aab3_b8ba6dccbc3d
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
name: SLC13A2
is: E7ETH5
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:9058

metaR DM T antigen g
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_03f59bed_0e60_4090_b70b_b86efcf46636
is: P28332
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:130
boundary condition: true
name: ADH6
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_4d0d3ff8_2f8c_4a1b_9eea_ed9856e20db5
initial amount: NaN
is: Q99714
name: HSD17B10
type: Species
boundary condition: true
is encoded by: hsa:3028
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR S6T6g
is: SBO:0000176
reactant: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000000
modifier: MODEL1310110053#
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110053#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_456a072c_404c_4ef3_92e9_8bb8f248488c
is: SBO:0000297
is encoded by: hsa:6241
initial amount: NaN
boundary condition: true
has part: P31350
has only substance units: false
has part: P23921
type: Species
constant: false
initial concentration: NaN
name: RRM1:RRM2
is encoded by: hsa:6240

metaR UGT1A10r
kinetic law: MODEL1310110053#
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.17
type: Reaction
is: SBO:0000176
modifier: MODEL1310110053#
product: MODEL1310110053#
reversible: true
fast: false
is described by: ECO:0000134

metaR r1106
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
name: Postulated transport reaction

metaR LNLCCRNt
product: MODEL1310110053#
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110053#
is: SBO:0000185
type: Reaction
reversible: false
reactant: MODEL1310110053#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_5c137532_8916_42dc_9c01_3bafffa2dada
constant: false
is: O75038
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
name: PLCH2
has only substance units: false
is encoded by: hsa:9651

http://identifiers.org/biomodels.db/MODEL1310110053#_a2f8e91d_37c5_41ef_9863_7e6cb46fca3c
is: P30613
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5313
type: Species
name: PKLR
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false

metaM CE5786 e
has only substance units: false
initial amount: NaN
is: CHEBI:27485
initial concentration: 1.0
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
boundary condition: false
type: Species
constant: false
name: kinetensin
is: HMDB02710
is: SBO:0000247

metaR r1645
product: MODEL1310110053#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
reactant: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR r0931
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reversible: false
name: Transport reaction
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_3d69d2c8_5921_4e0a_932d_c862a3b12360
is: Q9NT06
constant: false
boundary condition: true
has only substance units: false
name: HMGCLL1
type: Species
initial concentration: NaN
is encoded by: hsa:54511
initial amount: NaN
is: SBO:0000252

metaM pi x
type: Species
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial concentration: 1.0
is: HMDB00973
is: SBO:0000247
initial amount: NaN
name: hydrogenphosphate
is: CHEBI:43474
constant: false
boundary condition: false
has only substance units: false

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaR RE2649C
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110053#
product: MODEL1310110053#
name: RE2649
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176
reactant: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
reversible: true
is described by: ECO:0000000

metaM HC02175 c
type: Species
is: CHEBI:27689
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
initial amount: NaN
name: caprate
is: SBO:0000247

metaM hs deg8 l
name: heparan sulfate, degradation product 8
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:16126
notes: FORMULA: C69H100N4O81S8 CHARGE: -10

metaR RE3050R
product: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
reversible: true
name: RE3050
kinetic law: MODEL1310110053#
fast: false
is: SBO:0000176
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_2828965b_c7d0_428d_98e0_853040abcbe1
has only substance units: false
type: Species
constant: false
is: Q7Z7M8
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:374907
initial amount: NaN
name: B3GNT8

http://identifiers.org/biomodels.db/MODEL1310110053#_dde53a5f_0d50_4c19_8138_03407e0da6d7
is: P13196
is: SBO:0000252
is encoded by: hsa:211
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false
name: ALAS1

metaM gal1p c
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
type: Species
initial amount: NaN
is: CHEBI:58336
has only substance units: false
initial concentration: 1.0
is: HMDB00645
boundary condition: false
constant: false
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
is: SBO:0000247

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaR r0339
is described by: ECO:0000000
product: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.1.2.22
type: Reaction
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.3.1.65
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110053#_d10f7fb5_00f7_4a54_aeb6_a48c05f58405
constant: false
name: PHPT1
is encoded by: hsa:29085
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: Q9P019
initial concentration: NaN
boundary condition: true

metaM 42A3HP24DB c
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
is: SBO:0000247
constant: false
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
is: http://identifiers.org/pubchem.compound/7956
type: Species
is: HMDB04083
is: C05645

metaR PHEATB0tc
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Phenylalanine into the intestinal cells by ATB0 transporter
type: Reaction

metaM ddcacoa m
is: SBO:0000247
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: C01832
initial concentration: 1.0
is: CHEBI:57375
has only substance units: false
constant: false
boundary condition: false
is: HMDB03571
name: Dodecanoyl-CoA (n-C12:0CoA)
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_164aa69f_3ab6_42dc_9a25_67c857a8b3be
is encoded by: hsa:2592
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: B4E097
has only substance units: false
type: Species
constant: false
name: GALT

metaR BAAT4x
fast: false
modifier: MODEL1310110053#
is: SBO:0000176
reactant: MODEL1310110053#
is described by: ECO:0000304
type: Reaction
product: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:fourth version analog added in similarity to BAAT1x, BAAT2x NJ
is version of: http://identifiers.org/ec-code/2.3.1.65
name: bile acid Coenzyme A: amino acid N-acyltransferase

metaM andrstrn e
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:16032
has only substance units: false
type: Species
is: HMDB00031
is: SBO:0000247
constant: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
name: androsterone

metaR r0989
kinetic law: MODEL1310110053#
is: SBO:0000185
product: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
name: Postulated transport reaction
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reversible: true
is described by: ECO:0000000

metaR r0202
kinetic law: MODEL1310110053#
type: Reaction
reversible: true
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
reactant: MODEL1310110053#
product: MODEL1310110053#
fast: false

metaM dgdp c
name: dGDP
is: CHEBI:58595
is: C00361
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
constant: false
is: HMDB00960
has only substance units: false
type: Species

metaR ACGAM6PSi
fast: false
product: MODEL1310110053#
reversible: false
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (64841.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.3.1.4 Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110053#
name: N-acetylglucosamine-6-phosphate synthase
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.3.1.4
is described by: ECO:0000304
type: Reaction

metaM pail hs c
is: CHEBI:57880
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
name: 1-phosphatidyl-1D-myo-inositol(1-)

http://identifiers.org/biomodels.db/MODEL1310110053#_f5b6b2b5_8715_4a5b_9bc4_04d56c548135
name: _AI620219_1_e
is encoded by: hsa:AI620219
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species

metaR INSTt4 2
fast: false
reactant: MODEL1310110053#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110053#
reversible: true
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
is described by: ECO:0000006
kinetic law: MODEL1310110053#
name: inositol transport via sodium symport

http://identifiers.org/biomodels.db/MODEL1310110053#_175bc669_f0a5_4501_b90c_05cd6012c095
boundary condition: true
is encoded by: hsa:158
initial amount: NaN
constant: false
name: ADSL
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_f5bef7c3_9ba2_4e4c_97d7_30488f502455
is encoded by: hsa:83715
initial concentration: NaN
type: Species
name: ESPN
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is: B1AK53

metaR TXA2tr
reactant: MODEL1310110053#
name: thromboxane A2 intracellular transport
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tr -> TXA2te to get to EC space NJ
type: Reaction
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_589ddc97_fcf8_4b00_8b51_12062cfa5586
is encoded by: hsa:57786
type: Species
is: Q9NYW8
name: RBAK
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_00e971d2_d218_47a2_8c49_644c7bdd27b6
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is: O95497
is encoded by: hsa:8876
constant: false
name: VNN1

metaM 5mthf e
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: C00440
type: Species
notes: FORMULA: C20H24N7O6 CHARGE: -1
initial amount: NaN
name: 5-Methyltetrahydrofolate
is: SBO:0000247
is: HMDB01396
is: CHEBI:3729

metaR RDH2a
is described by: ECO:0000269
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
reversible: true
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.1.1.300
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110053#
name: retinol dehydrogenase (9-cis,NADPH)
is version of: http://identifiers.org/ec-code/1.1.1.105

metaM h x
has only substance units: false
is: SBO:0000247
name: proton
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: C00080
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: CHEBI:24636
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380

http://identifiers.org/biomodels.db/MODEL1310110053#_b582563b_72d2_4049_ab05_c095fc5031aa
has only substance units: false
boundary condition: true
type: Species
is: Q9H6Y6
is: SBO:0000252
is encoded by: hsa:4645
name: MYO5B
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_3297788e_ddd9_45a6_a9fb_0d2740a161b3
constant: false
name: MUT
is: SBO:0000252
is encoded by: hsa:4594
has only substance units: false
boundary condition: true
is: P22033
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_53c55eb5_767c_44c5_a754_e67437fd8088
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:8529
is: P78329
name: CYP4F2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_65090b91_446f_4f4a_b4d4_7dab1738a840
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is: O94808
name: GFPT2
initial amount: NaN
is encoded by: hsa:9945
initial concentration: NaN

metaR MTHFDm
modifier: MODEL1310110053#
is: SBO:0000176
is described by: ECO:0000269
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
is version of: http://identifiers.org/ec-code/6.3.4.3
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.9
type: Reaction
kinetic law: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
reactant: MODEL1310110053#
fast: false

metaR GLCNACASE4ly
fast: false
is: SBO:0000176
modifier: MODEL1310110053#
product: MODEL1310110053#
name: alpha-N-acetylglucosaminidase, lysosomal
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.50
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110053#_53a6c0d8_6bb8_463b_9c5d_290f31f03349
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: B7Z1R0
name: SLC4A10
is: SBO:0000252
is encoded by: hsa:57282
constant: false

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaM cbasp c
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00828
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: C00438
name: N-Carbamoyl-L-aspartate
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
is: CHEBI:32814

metaR r1109
type: Reaction
reactant: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
kinetic law: MODEL1310110053#
fast: false
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
is described by: ECO:0000000
reversible: true
is: SBO:0000176

metaM HC02175 e
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:27689
name: caprate

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaM ksi pre23 g
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
type: Species
has only substance units: false
is: CHEBI:28067
is: SBO:0000247
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 23
constant: false
boundary condition: false
initial concentration: 1.0

metaM dcamp c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: N6-(1,2-Dicarboxyethyl)-AMP
has only substance units: false
is: HMDB00536
is: C03794
constant: false
type: Species
is: CHEBI:57567
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794

metaR r1648
reversible: true
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110053#
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_4f5e505b_4d3b_410a_835f_b7bbe5b83873
is encoded by: hsa:956
constant: false
is: SBO:0000252
initial amount: NaN
name: ENTPD3
type: Species
has only substance units: false
is: O75355
initial concentration: NaN
boundary condition: true

metaR THBPT4ACAMDASE
type: Reaction
modifier: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.96
kinetic law: MODEL1310110053#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
reversible: false
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase

metaM so3 m
boundary condition: false
has only substance units: false
name: hydrogensulfite
constant: false
is: CHEBI:17137
initial concentration: 1.0
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: HMDB00240
is: SBO:0000247
initial amount: NaN
type: Species

metaR r0560
type: Reaction
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
reversible: false
is: SBO:0000176
reactant: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
kinetic law: MODEL1310110053#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_fbc9569c_0698_4869_8b78_65c15433af32
has only substance units: false
is: SBO:0000252
is encoded by: hsa:84532
type: Species
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: ACSS1
is: Q9NUB1

metaM ksii core2 pre6 g
is: SBO:0000247
is: CHEBI:28067
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 6
type: Species
notes: FORMULA: C61H98N5O46SX CHARGE: -2
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false

metaM leugly c
notes: FORMULA: C8H16N2O3 CHARGE: 0
initial amount: NaN
is: SBO:0000247
name: Leucylglycine
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/97364
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_bb10dfac_2550_4461_8a45_6c292f8a0e7f
name: TPI1P2
has only substance units: false
constant: false
is encoded by: hsa:286016
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_196f692e_b449_4b26_901a_acb021c68242
is encoded by: hsa:5092
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: PCBD1
type: Species
is: P61457
constant: false

metaM for e
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:15740
initial concentration: 1.0
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
constant: false
has only substance units: false
is: HMDB00142
name: formate

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

metaR r1649
reactant: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
product: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR GLYt7 311 r
reversible: true
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
type: Reaction
name: glycine reversible transport via sodium and chloride symport (3:1:1)
fast: false
is described by: ECO:0000006
reactant: MODEL1310110053#
product: MODEL1310110053#

metaM 5mthf c
initial concentration: 1.0
name: 5-Methyltetrahydrofolate
type: Species
is: HMDB01396
has only substance units: false
boundary condition: false
is: C00440
is: SBO:0000247
is: CHEBI:3729
constant: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
initial amount: NaN

metaR RETNt
product: MODEL1310110053#
name: retinoic acid transport
fast: false
reactant: MODEL1310110053#
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
is: SBO:0000185

metaR HEX4
modifier: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
is described by: ECO:0000304
kinetic law: MODEL1310110053#
reversible: false
name: hexokinase (D-mannose:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.2
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.1
is: SBO:0000176

metaR HYXNt
fast: false
name: Hypoxanthine transport
modifier: MODEL1310110053#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
product: MODEL1310110053#
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000269
is: SBO:0000185

metaR EX dchac LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for deoxycholic acid
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_d2b0d534_1818_42d2_84ae_2ba65c7cd3f2
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:116369
name: SLC26A8
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_773b26c3_cb8e_44c9_b325_4b075e4951b0
initial concentration: NaN
constant: false
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:AF080579
is: SBO:0000252
name: _AF080579_1_c

metaR biomass reaction
is: SBO:0000185
name: biomass_reaction
fast: false
product: MODEL1310110053#
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110053#

metaR r1384
type: Reaction
reversible: true
reactant: MODEL1310110053#
is described by: ECO:0000000
name: Guanosine aminohydrolase EC:3.5.4.15
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
kinetic law: MODEL1310110053#
fast: false
product: MODEL1310110053#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110053#_0a21966b_1eba_4f42_9077_d8f9b62b35f9
is: P27708
initial concentration: NaN
has only substance units: false
is encoded by: hsa:790
name: CAD
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false

metaR SGPL12r
type: Reaction
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/4.1.2.27
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
modifier: MODEL1310110053#
is: SBO:0000176
kinetic law: MODEL1310110053#
reversible: false
is described by: ECO:0000304
name: Sphingosine-1-phosphate lyase
fast: false
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_9b9bb969_cb01_4abe_9638_cd09ee723598
boundary condition: true
name: _AI480132_1_c
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:AI480132
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_cc388a40_1078_44e4_9f55_70a95dac4867
name: _AD000092_1_c
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:AD000092
has only substance units: false

metaM lald L c
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
boundary condition: false
name: (S)-lactaldehyde
type: Species
initial concentration: 1.0
is: HMDB03052
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:18041

metaR RE1532M
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
name: RE1532
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110053#
reversible: true
reactant: MODEL1310110053#
product: MODEL1310110053#
modifier: MODEL1310110053#

metaR r1301
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
kinetic law: MODEL1310110053#
reversible: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110053#
name: Vesicular transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_deff35bf_dd8e_49dd_ad0e_0b5c3fe3c096
type: Species
is encoded by: hsa:66035
initial concentration: NaN
name: SLC2A11
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is: Q8WXF9

metaR r1665
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110053#
is described by: ECO:0000000
type: Reaction
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_0bf282f1_c9fc_45a1_bcb8_a0640e60bdb5
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: CTH
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1491
is: P32929

metaM dgsn c
type: Species
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
boundary condition: false
is: SBO:0000247
is: HMDB00085
is: CHEBI:17172
initial concentration: 1.0
initial amount: NaN
is: C00330
has only substance units: false
constant: false
name: Deoxyguanosine

metaR GLXtm
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
name: glyoxylate transport, mitochondrial
product: MODEL1310110053#
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110053#
is: SBO:0000185
fast: false

metaM 2mb2coa m
type: Species
is: CHEBI:57337
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
initial concentration: 1.0
is: HMDB02054
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
name: 2-methylcrotonoyl-CoA(4-)
is: SBO:0000247

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

metaR XYLTt
reactant: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
type: Reaction
is described by: ECO:0000000
name: Xylitol transport via passive diffusion
is: SBO:0000185
reversible: true
product: MODEL1310110053#

metaR DHCR242r
reversible: false
name: 24-dehydrocholesterol reductase [Precursor]
product: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
is described by: ECO:0000134
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.72
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110053#_1cb2397a_9fef_4ebf_903c_e74c861e3e0e
name: PMM1
boundary condition: true
is: A8K003
constant: false
is: SBO:0000252
is encoded by: hsa:5372
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR GALNTg
is described by: ECO:0000000
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
modifier: MODEL1310110053#
fast: false
reversible: false
name: GalNAc transferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.41
product: MODEL1310110053#
type: Reaction

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaR ITCOAL1m
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
product: MODEL1310110053#
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
fast: false
is: SBO:0000176
is described by: ECO:0000304
reactant: MODEL1310110053#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_284db3de_bd2f_46e8_bf33_15a4b23109fd
boundary condition: true
is encoded by: hsa:H77542
is: SBO:0000252
type: Species
initial amount: NaN
name: _H77542_1_r
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_63f512ed_add1_4168_a51a_bdad02a32487
boundary condition: true
initial amount: NaN
type: Species
name: DGKD
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8527
is: SBO:0000252
constant: false

metaR r1934
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaM fad r
name: Flavin adenine dinucleotide oxidized
is: SBO:0000247
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
has only substance units: false
constant: false
is: HMDB01248
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:16238
type: Species

metaR BTNt2
name: Biotin reversible transport via proton symport
reactant: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
modifier: MODEL1310110053#
reversible: true
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110053#
product: MODEL1310110053#
type: Reaction

metaR r1302
name: Vesicular transport
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110053#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110053#

metaM glu L e
is: CHEBI:29985
boundary condition: false
name: L-glutamate(1-)
constant: false
initial amount: NaN
is: HMDB00148
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025

http://identifiers.org/biomodels.db/MODEL1310110053#_6c665fb6_7413_450d_8c15_b64b0fab1e64
type: Species
initial amount: NaN
name: _AI440329_1_r
is encoded by: hsa:AI440329
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_912435b9_29f8_4749_a707_f7bb1c7f06bd
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q9ULD0
name: OGDHL
is: SBO:0000252
constant: false
is encoded by: hsa:55753
boundary condition: true
type: Species

metaR r1664
name: Y+LAT2 Utilized transport
fast: false
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_66825173_c1c5_48b2_8d6c_b57d0ab80177
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:1607
initial concentration: NaN
has only substance units: false
name: DGKB

http://identifiers.org/biomodels.db/MODEL1310110053#_879a29a6_706f_4bb4_8ec3_fb55ac5a01ec
constant: false
name: B3GNT2
type: Species
has only substance units: false
is encoded by: hsa:10678
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM so3 c
is: SBO:0000247
is: CHEBI:17137
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
name: Sulfite
constant: false
has only substance units: false
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: C00094
is: HMDB00240

metaR RE1526M
name: RE1526
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_a154a502_b35a_4865_8dfb_88e3c48d9db4
name: GALNT14
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:79623
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q96FL9

metaR GMPtg
is described by: ECO:0000269
product: MODEL1310110053#
fast: false
type: Reaction
kinetic law: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
name: GMP transport (Golgi)
reactant: MODEL1310110053#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110053#_d5875307_5055_4759_90d0_05cce042ea73
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is: Q969I6
has only substance units: false
name: SLC38A4
is encoded by: hsa:55089
initial amount: NaN

metaR BUTt2r
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
reversible: true
name: Butyrate transport via proton symport, reversible
is: SBO:0000185
kinetic law: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
modifier: MODEL1310110053#
product: MODEL1310110053#

metaR ATPtm
kinetic law: MODEL1310110053#
product: MODEL1310110053#
fast: false
type: Reaction
modifier: MODEL1310110053#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reactant: MODEL1310110053#
name: ADP/ATP transporter, mitochondrial
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110053#_9ed7e169_8277_47ba_a54d_ec623fa1097f
is: P49441
boundary condition: true
initial amount: NaN
is encoded by: hsa:3628
name: INPP1
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species

metaR r0522
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
kinetic law: MODEL1310110053#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
type: Reaction
product: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110053#

metaM dudp m
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01000
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
name: dUDP(3-)
is: CHEBI:60471
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_a444e2c2_a5f4_43af_b324_3506efaaa031
initial amount: NaN
has only substance units: false
is: Q9NPC4
initial concentration: NaN
name: A4GALT
type: Species
is encoded by: hsa:53947
boundary condition: true
is: SBO:0000252
constant: false

metaR r1667
modifier: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000185
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110053#_67f526a6_faaf_4271_bd12_e477e5ae9e1e
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
name: GK3P
initial concentration: NaN
is encoded by: hsa:2713

metaR G14T7g
is: SBO:0000176
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
kinetic law: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
product: MODEL1310110053#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.38

http://identifiers.org/biomodels.db/MODEL1310110053#_c3591208_8ee5_41eb_aaa1_34ac9c41aa4b
is encoded by: hsa:79053
name: ALG8
initial concentration: NaN
is: SBO:0000252
is: A6NDW6
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_bd21af1f_4dab_4b34_ab4f_e199e023c7b9
constant: false
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is: Q96BD0
name: SLCO4A1
is encoded by: hsa:28231
initial concentration: NaN
initial amount: NaN

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_8ee4c4aa_b0a3_4f85_b4c0_30c4bbed9ec7
has only substance units: false
initial amount: NaN
name: GCNT1
is: SBO:0000252
boundary condition: true
type: Species
is: Q02742
is encoded by: hsa:2650
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_e423ee45_5c0f_40ed_a1e9_f737a508a0f7
type: Species
initial amount: NaN
initial concentration: NaN
name: PANK1
constant: false
has only substance units: false
is encoded by: hsa:53354
is: Q8TE04
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_6f9d3d98_7ebe_4adc_bcca_f5094160773b
is encoded by: hsa:642502
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
constant: false
name: _642502_1_c
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_4446ab6c_a043_4e8e_a3d9_6f263e54aec3
initial amount: NaN
is: P41222
name: PTGDS
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5730
boundary condition: true
constant: false

metaR RE1845C
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110053#
reversible: true
type: Reaction
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
fast: false
name: RE1845

http://identifiers.org/biomodels.db/MODEL1310110053#_1fc7f422_2cf8_4f2d_b2fd_a25203f0f054
name: NDUFB5
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:4711
has only substance units: false
is: O43674

http://identifiers.org/biomodels.db/MODEL1310110053#_f0089720_1718_4ec9_8643_1894e7a5244f
is: B3KVI7
type: Species
is encoded by: hsa:3712
initial concentration: NaN
name: IVD
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false

metaR r1666
modifier: MODEL1310110053#
fast: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110053#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110053#
reversible: true
reactant: MODEL1310110053#

metaM sucsal m
constant: false
name: Succinic semialdehyde
initial concentration: 1.0
has only substance units: false
is: HMDB01259
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
is: CHEBI:57706
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species

metaM m4masn g
notes: FORMULA: C46H77N2O35X CHARGE: 0
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
is: C05881
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

metaR GTHRDt
is described by: ECO:0000000
product: MODEL1310110053#
name: Glutathione transport into mitochondria
reactant: MODEL1310110053#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110053#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.

metaR r1661
reactant: MODEL1310110053#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110053#
reversible: true
modifier: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR CREATt4 2 r
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110053#
name: Creatine transport (sodium symport) (2:1)
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110053#
product: MODEL1310110053#

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR r1450
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: EC:1.3.3.6
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
type: Reaction
product: MODEL1310110053#
reversible: false
kinetic law: MODEL1310110053#

metaR AICART
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
kinetic law: MODEL1310110053#
type: Reaction
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.1.2.3
product: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110053#_ba4eeb11_e5bc_4e94_b49d_afad2378b5e2
is encoded by: hsa:6487
name: ST3GAL3
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
initial concentration: NaN

metaR DOLPMT U
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.83
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
type: Reaction
name: Dolichyl-phosphate D-mannosyltransferase (uterus)
fast: false
modifier: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_7a11a71f_627f_4f58_aa4f_c84d87f7f208
has only substance units: false
is encoded by: hsa:55350
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
name: VNN3

http://identifiers.org/biomodels.db/MODEL1310110053#_fb02b516_2c6e_4a9d_817d_701a7f59ab06
has only substance units: false
constant: false
is: P35557
initial amount: NaN
is encoded by: hsa:2645
is: SBO:0000252
name: GCK
initial concentration: NaN
boundary condition: true
type: Species

metaR r2309
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
fast: false
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
kinetic law: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000185

metaR r0310
reversible: false
kinetic law: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
product: MODEL1310110053#
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:

metaM pail45p hs c
name: phosphatidylinositol 4,5-bisphosphate
initial amount: NaN
type: Species
is: CHEBI:28910
boundary condition: false
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

metaM sphs1p c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: CHEBI:60119
name: sphingosine 1-phosphate(1-)
is: HMDB00277
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_578f9c3a_a704_44c0_9ade_b31d4b90cbb0
initial concentration: NaN
is encoded by: hsa:4728
name: NDUFS8
constant: false
has only substance units: false
is: O00217
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_4fc6a0b7_ead2_41d1_aaef_28b9d893b1c3
boundary condition: true
is encoded by: hsa:51301
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: Q9P109
is: SBO:0000252
type: Species
name: GCNT4

metaR IDOAASE3ly
fast: false
reversible: false
product: MODEL1310110053#
name: alpha-L-iduronidase, lysosomal
reactant: MODEL1310110053#
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.2.1.76
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD

metaR RE3014R
is version of: http://identifiers.org/ec-code/1.14.13.30
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8529.1) or (4051.1) or (126410.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.13.30 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9799565,PMID:9862787 NOTES:
modifier: MODEL1310110053#
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110053#
name: RE3014
is: SBO:0000176
reactant: MODEL1310110053#
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_05a23b82_1ac6_4e1e_a4de_9e3dbf1d1df1
initial concentration: NaN
has only substance units: false
constant: false
name: HSD17B4
is encoded by: hsa:3295
type: Species
is: SBO:0000252
initial amount: NaN
is: E9PB82
boundary condition: true

metaR r1660
kinetic law: MODEL1310110053#
type: Reaction
is: SBO:0000185
product: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
modifier: MODEL1310110053#
is described by: ECO:0000000

metaR DM Lcystin
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for L-cystine
type: Reaction

metaM ksii core2 pre8 g
is: CHEBI:58053
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C75H121N6O56SX CHARGE: -2
initial amount: NaN
is: SBO:0000247
is: C00130
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 8
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_f5fb698f_ffbc_45f6_bf5d_79d10165d538
initial amount: NaN
type: Species
boundary condition: true
name: MAN2B1
is: O00754
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4125

metaR S6T2g
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110053#
product: MODEL1310110053#
modifier: MODEL1310110053#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false

metaM CE2420 m
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
is: CHEBI:28387
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
is: HMDB11123
initial concentration: 1.0
type: Species

metaR r0523
fast: false
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
type: Reaction
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110053#
is described by: ECO:0000000
reactant: MODEL1310110053#

metaR r1156
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
reversible: true
type: Reaction

metaM utp n
has only substance units: false
name: UTP(4-)
is: SBO:0000247
type: Species
is: CHEBI:46398
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: HMDB00285

metaM hs deg11 l
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C55H81N3O67S7 CHARGE: -8
constant: false
is: CHEBI:57737
is: HMDB00868
name: heparan sulfate, degradation product 11

metaM gam6p c
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
type: Species
boundary condition: false
initial amount: NaN
is: HMDB01254
name: D-Glucosamine 6-phosphate
is: CHEBI:12962
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_35d68f7e_6fc3_43bd_87c8_5446232d9439
is encoded by: hsa:51109
boundary condition: true
type: Species
is: B4DDW0
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
name: RDH11
initial concentration: NaN

metaR ALCD22 L
kinetic law: MODEL1310110053#
name: alcohol dehydrogenase (L-lactaldehyde)
reactant: MODEL1310110053#
is described by: ECO:0000304
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.1
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.1.99.24
fast: false
notes: GENE_ASSOCIATION: (126.1) or (137872.1) or (126.1 and 124.1) or (127.1) or (130.1) or (284273.1) or (125.1 and 124.1) or (128.1) or (124.1) or (125.1) or (284273.2) or (131.1) or (125.1 and 126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
modifier: MODEL1310110053#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_e5219b7c_f840_41c8_8149_1cbed5682ded
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1349
constant: false
type: Species
initial amount: NaN
is: P24311
name: COX7B
has only substance units: false
initial concentration: NaN

metaR DM fol
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_2e8077a5_eddc_4be4_adef_111a6d3b58f2
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:50700
type: Species
has only substance units: false
name: RDH8
is: Q9NYR8
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_ea8cbfa1_692d_4fb5_a80f_74cbd93bb7e3
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: O43426
initial concentration: NaN
is encoded by: hsa:8867
has only substance units: false
name: SYNJ1
is: SBO:0000252

metaR r2068
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110053#
type: Reaction
reversible: false
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
modifier: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#

metaM prostgd2 r
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
constant: false
is: HMDB01403
is: CHEBI:57406
name: prostaglandin D2(1-)
has only substance units: false
initial concentration: 1.0

metaM thbpt4acam c
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: HMDB02281
initial amount: NaN
is: SBO:0000247
name: 4a-hydroxytetrahydrobiopterin
has only substance units: false
initial concentration: 1.0
is: CHEBI:15374
constant: false
type: Species
boundary condition: false

metaM sphs1p e
initial amount: NaN
is: SBO:0000247
is: CHEBI:60119
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: HMDB00277
constant: false
boundary condition: false
name: sphingosine 1-phosphate(1-)
type: Species

metaM paps g
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: HMDB01134
is: CHEBI:58339
is: SBO:0000247
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false

metaR EX oxa LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_ab94c6e9_85d5_44e3_9932_10870317e415
initial amount: NaN
is encoded by: hsa:7263
is: SBO:0000252
has only substance units: false
type: Species
name: TST
initial concentration: NaN
is: Q16762
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_c4c25bba_5015_4862_a2a1_356ee1444720
type: Species
is encoded by: hsa:AI990637
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: _AI990637_1_x
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_7aac7553_1ea2_4ebc_903f_78889619afe9
boundary condition: true
initial amount: NaN
is: Q05C14
initial concentration: NaN
type: Species
is encoded by: hsa:2352
constant: false
name: FOLR3
has only substance units: false
is: SBO:0000252

metaR r1662
fast: false
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110053#
is described by: ECO:0000000
reactant: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#

metaM glu L c
type: Species
is: CHEBI:29985
name: L-glutamate(1-)
initial concentration: 1.0
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00148
is: SBO:0000247
boundary condition: false

metaR r1453
is: SBO:0000176
reactant: MODEL1310110053#
is described by: ECO:0000000
fast: false
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
type: Reaction
reversible: true
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_726c6ea6_62a9_4282_9473_fef464293865
name: IDH2
is encoded by: hsa:3418
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: P48735

metaM ethamp c
constant: false
initial amount: NaN
name: ethamp[c]
is: CHEBI:58190
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
boundary condition: false
initial concentration: 1.0
is: HMDB00224

metaR r0311
reversible: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110053#
is: SBO:0000176
reactant: MODEL1310110053#
fast: false
type: Reaction
is described by: ECO:0000000
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
is version of: http://identifiers.org/ec-code/2.3.1.9
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaR r0267
is described by: ECO:0000000
reactant: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
type: Reaction
kinetic law: MODEL1310110053#
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is version of: http://identifiers.org/ec-code/3.5.1.9
product: MODEL1310110053#
is: SBO:0000176
fast: false
modifier: MODEL1310110053#

metaR r1936
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false
product: MODEL1310110053#
is: SBO:0000185
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
is described by: ECO:0000000
fast: false

metaR SARCStex
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:5096515 NOTES:MM
reactant: MODEL1310110053#
is: SBO:0000185
name: Sarcosine transport (extracellular to cytosol)
type: Reaction
product: MODEL1310110053#
reversible: false

metaM HC00342 m
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
constant: false
is: CHEBI:16383
name: cis-aconitate(3-)

metaR r0268
is version of: http://identifiers.org/ec-code/3.1.3.1
fast: false
kinetic law: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.1.3.2
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
is: SBO:0000176
reversible: true
is described by: ECO:0000000
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2

metaR RE0577C
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
kinetic law: MODEL1310110053#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110053#
is described by: ECO:0000000
fast: false
name: RE0577
product: MODEL1310110053#
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176

metaM gmp g
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01397
is: CHEBI:58115
is: SBO:0000247
has only substance units: false
name: GMP(3-)
type: Species
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144

http://identifiers.org/biomodels.db/MODEL1310110053#_805e6788_480f_4f9f_b528_fc84d164288a
is: SBO:0000252
name: UCK2
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: Q9BZX2
is encoded by: hsa:7371
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_4fd1f0c2_2acb_41ea_99e2_823d4272624a
is encoded by: hsa:57835
initial amount: NaN
is: Q9BY07
name: SLC4A5
type: Species
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_6c7ad989_dbbf_4b17_95bc_9b7e637ab6e1
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252
name: DGKB
boundary condition: true
initial amount: NaN
is: Q9Y6T7
is encoded by: hsa:1607

http://identifiers.org/biomodels.db/MODEL1310110053#_117d0397_4eef_44b4_963e_d66bff32ffbc
has only substance units: false
type: Species
constant: false
is encoded by: hsa:6241
name: RRM2
initial amount: NaN
boundary condition: true
is: P31350
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_9af02747_7f4b_412c_bcea_bfc3e9ca0c6f
is encoded by: hsa:1351
type: Species
constant: false
is: SBO:0000252
is: Q53XN1
initial concentration: NaN
boundary condition: true
name: COX8A
initial amount: NaN
has only substance units: false

metaR r2124
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
product: MODEL1310110053#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_88346488_84af_445e_aa57_51078443cf47
is encoded by: hsa:8818
boundary condition: true
type: Species
is: SBO:0000297
has only substance units: false
constant: false
initial concentration: NaN
name: DPM3:DPM1:DPM2
initial amount: NaN
is encoded by: hsa:54344
has part: Q9P2X0

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaR 34DHPLACOX
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: (218.1) or (222.1) or (220.1) or (221.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
type: Reaction
fast: false
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
reactant: MODEL1310110053#
is described by: ECO:0000269
name: 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase

metaR r0156
is: SBO:0000176
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.1.40
is described by: ECO:0000000
fast: false
reversible: false
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
type: Reaction
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#

metaR r2123
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110053#
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110053#_a22dccda_cf24_49df_b803_7b9226f94a07
is: SBO:0000252
boundary condition: true
name: SLC5A2
is: P31639
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:6524
has only substance units: false
constant: false

metaR r0527
is: SBO:0000176
reactant: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
is described by: ECO:0000000
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
reversible: true

metaR r2063
is: SBO:0000185
product: MODEL1310110053#
is described by: ECO:0000000
modifier: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: false

metaR HS4ly
fast: false
product: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
reactant: MODEL1310110053#
reversible: false
modifier: MODEL1310110053#
is described by: ECO:0000000
type: Reaction
name: heparan-N-sulfatase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.10.1.1

metaM HC00460 c
boundary condition: false
name: 2,5-dihydroxybenzoate
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
has only substance units: false
is: CHEBI:58044
constant: false
initial concentration: 1.0

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaM ethamp r
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
boundary condition: false
type: Species
name: O-phosphonatoethanaminium(1-)
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:58190
is: HMDB00224
is: SBO:0000247

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_7907fa4f_aa0f_4c41_92d3_af57ddf1b8ce
is: Q1ET61
is encoded by: hsa:6818
boundary condition: true
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: SULT1A3
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_7065849d_c5fd_4de3_845c_8b761eca8d55
is: Q6YFQ2
name: COX6B2
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:125965
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_44854cee_2a2e_4941_a2e2_f1b86e16c3f8
is encoded by: hsa:55350
constant: false
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
name: VNN3:VNN2:VNN1

http://identifiers.org/biomodels.db/MODEL1310110053#_0ae08f87_2773_4382_94e4_86c62c13c04d
is encoded by: hsa:AW277253
name: _AW277253_1_c
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM m6masnB2 g
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:57312
initial amount: NaN
has only substance units: false
is: HMDB01356
constant: false
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
notes: FORMULA: C58H97N2O45X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110053#_4d9d1c4c_6cc6_4e5f_ab2b_e38fff78a0f2
is encoded by: hsa:8875
is encoded by: hsa:55350
constant: false
type: Species
boundary condition: true
is: SBO:0000297
name: VNN3:VNN2:VNN1
has only substance units: false
initial amount: NaN
has part: O95498
initial concentration: NaN

metaR H2Otly
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110053#
reversible: true
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: H2O transport, lysosomal
kinetic law: MODEL1310110053#

metaR GLCAASE8ly
reversible: false
reactant: MODEL1310110053#
is described by: ECO:0000269
product: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
type: Reaction
name: beta-glucuronidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.31
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD

metaR r0157
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is: SBO:0000176
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/6.3.4.2
modifier: MODEL1310110053#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_4a1675db_6898_43d7_9d3c_2393234d7076
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:M68895
name: _M68895_1_c
type: Species

metaR r2126
fast: false
modifier: MODEL1310110053#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110053#
reversible: true
reactant: MODEL1310110053#

metaR AG13T10g
reversible: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110053#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110053#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaM ak2lgchol hs e
is: http://identifiers.org/pubchem.compound/6975
initial concentration: 1.0
is: C04317
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
initial amount: NaN
type: Species
has only substance units: false
name: 1-alkyl 2-lysoglycerol 3-phosphocholine

metaR G14Tg
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000176
type: Reaction
product: MODEL1310110053#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000269
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase

metaR GMAND
modifier: MODEL1310110053#
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/4.2.1.47
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (2762.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.2.1.47 Confidence Level: 0 AUTHORS: NOTES:JLR
name: GDP-D-mannose dehydratase
is: SBO:0000176
reversible: false

metaM retinal c
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
type: Species
is: CHEBI:15035
is: HMDB01358
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: retinal

http://identifiers.org/biomodels.db/MODEL1310110053#_315adf12_2052_4e9e_8ed5_530f10dbf34d
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:10905
initial concentration: NaN
constant: false
is: O60476
type: Species
name: MAN1A2

http://identifiers.org/biomodels.db/MODEL1310110053#_21c6ddfa_2516_43cc_8c31_bcd8dbdb321e
is encoded by: hsa:248
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is: P09923
name: ALPI
type: Species
initial amount: NaN

metaR TYMSFt
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
reactant: MODEL1310110053#
reversible: false
name: Tyramine O-sulfate transport (diffusion)
is described by: ECO:0000000
product: MODEL1310110053#
kinetic law: MODEL1310110053#

metaM ksi pre3 g
initial amount: NaN
has only substance units: false
constant: false
name: keratan sulfate I biosynthesis, precursor 3
initial concentration: 1.0
is: CHEBI:58053
is: C00130
boundary condition: false
notes: FORMULA: C93H152N6O67X CHARGE: -1
type: Species
is: SBO:0000247
is: HMDB00175

metaR ARACHDt2
kinetic law: MODEL1310110053#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110053#
name: fatty acid transport via diffusion
reactant: MODEL1310110053#

metaR HS3ly
product: MODEL1310110053#
modifier: MODEL1310110053#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.10.1.1
reversible: false
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
name: heparan-N-sulfatase, lysosomal
kinetic law: MODEL1310110053#
fast: false
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_110ccfc4_bd5f_402a_a082_3b7b95be534d
type: Species
is: SBO:0000252
constant: false
name: SULT1A1
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:6817

http://identifiers.org/biomodels.db/MODEL1310110053#_de073339_85ff_4af8_a6ad_0941528c6f70
type: Species
initial amount: NaN
is: Q9GZR5
has only substance units: false
is: SBO:0000252
name: ELOVL4
boundary condition: true
constant: false
is encoded by: hsa:6785
initial concentration: NaN

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaR r2125
product: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110053#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

metaR G14T11g
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110053#
is described by: ECO:0000000
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110053#
reactant: MODEL1310110053#

metaR DTMPK
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.4.9
is described by: ECO:0000269
is: SBO:0000176
name: dTMP kinase
type: Reaction
fast: false
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_52ecc259_4e68_476f_b745_46e17674d64f
constant: false
is: SBO:0000252
is encoded by: hsa:250
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is: P05187
name: ALPP
type: Species

metaR GLYBt4 2 r
reversible: true
product: MODEL1310110053#
modifier: MODEL1310110053#
name: Betaine transport (sodium symport) (2:1)
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (6539.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
type: Reaction
reactant: MODEL1310110053#
fast: false
is described by: ECO:0000269

metaR DOPASULT
type: Reaction
is: SBO:0000176
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.8.2.1
reversible: false
name: Dopamine Sulfotransferase
fast: false
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)

metaM ksi pre29 g
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
type: Species
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 29
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:28067
boundary condition: false
initial amount: NaN

metaM CE2417 m
initial amount: NaN
type: Species
is: HMDB11123
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
is: CHEBI:28387
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_5434a124_8fed_4039_8de8_f8e81582a6b9
boundary condition: true
initial concentration: NaN
name: NME1
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:4830

metaR CYTK6n
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
name: cytidylate kinase (CMP,CTP),nuclear
modifier: MODEL1310110053#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is: SBO:0000176
reactant: MODEL1310110053#

metaR GDPtg
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
reactant: MODEL1310110053#
is: SBO:0000185
fast: false
product: MODEL1310110053#
name: GDP intracellular transport
type: Reaction
kinetic law: MODEL1310110053#
is described by: ECO:0000000

metaM ksi pre21 g
is: SBO:0000247
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 21
initial concentration: 1.0
is: HMDB00175
boundary condition: false
is: CHEBI:58053
type: Species
is: C00130
has only substance units: false
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
constant: false

metaR AK2LGCHOLt
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
name: 1-alkyl 2-acylglycerol 3-phosphocholine transport
reactant: MODEL1310110053#
reversible: true
kinetic law: MODEL1310110053#
fast: false
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.1.1.21 Confidence Level: 2 AUTHORS: PMID:2004782,PMID:2253271,PMID:8106516 NOTES:

metaM ak2lgchol hs c
constant: false
type: Species
is: C04317
is: http://identifiers.org/pubchem.compound/6975
initial amount: NaN
initial concentration: 1.0
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
has only substance units: false

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_2ea7d186_c409_42bc_aac6_31dda67c1410
is encoded by: hsa:2180
initial concentration: NaN
is: SBO:0000252
name: ACSL1
constant: false
boundary condition: true
is: P33121
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_c4ab48ee_f83a_4af2_b011_cbc27721b982
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6519
is: Q07837
has only substance units: false
initial concentration: NaN
name: SLC3A1
constant: false
initial amount: NaN

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaR FATP2t
reversible: true
type: Reaction
fast: false
is described by: ECO:0000269
modifier: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000185
reactant: MODEL1310110053#
name: fatty acid electroneutral transport
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ

metaR r2128
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110053#
type: Reaction
fast: false
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110053#

metaM ksi pre7 g
type: Species
notes: FORMULA: C115H187N8O85SX CHARGE: -2
is: SBO:0000247
is: HMDB00175
has only substance units: false
constant: false
is: CHEBI:58053
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: C00130
name: keratan sulfate I biosynthesis, precursor 7

http://identifiers.org/biomodels.db/MODEL1310110053#_00be5fd2_3920_48df_98d7_4102be73217d
is encoded by: hsa:6513
is: SBO:0000252
has only substance units: false
is: P11166
initial concentration: NaN
name: SLC2A1
initial amount: NaN
boundary condition: true
type: Species
constant: false

metaM CE0785 m
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
initial concentration: 1.0
initial amount: NaN
name: cis,cis-myristo-5,8-dienoyl-CoA
is: C01936
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_f216cf30_5445_43ce_b8ba_285b2d95f4f6
boundary condition: true
is encoded by: hsa:5330
is: Q59F77
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
name: PLCB2
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_ff25f698_6e9b_4c68_9da2_07cf1418521f
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:53354
boundary condition: true
name: PANK1
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_5a71c126_f247_4549_a90f_1633acfd5e85
initial amount: NaN
is: SBO:0000252
is: Q16739
boundary condition: true
is encoded by: hsa:7357
name: UGCG
initial concentration: NaN
constant: false
type: Species
has only substance units: false

metaM glyc R m
is: HMDB00139
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:16659
type: Species
name: D-glycerate
initial amount: NaN
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235

metaM gsn c
name: Guanosine
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00133
type: Species
has only substance units: false
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: C00387
boundary condition: false
is: SBO:0000247
is: CHEBI:16750

metaR r1459
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110053#
reversible: true
type: Reaction
product: MODEL1310110053#
fast: false
name: Transport reaction

metaR ACOAD8m
is: SBO:0000176
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.3.99.10
reversible: false
kinetic law: MODEL1310110053#
is described by: ECO:0000269
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3712.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 4 AUTHORS: PMID:9214289 NOTES:MM
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial
product: MODEL1310110053#
modifier: MODEL1310110053#

metaR AG13T4g
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
kinetic law: MODEL1310110053#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
reactant: MODEL1310110053#
reversible: false
is: SBO:0000176
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110053#
is described by: ECO:0000000

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

metaM 6pgl r
constant: false
initial amount: NaN
is: HMDB01127
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57955
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
initial concentration: 1.0
type: Species
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236

http://identifiers.org/biomodels.db/MODEL1310110053#_d8cadc87_a044_4b4e_8d93_3707b9a3e8f1
is: P17568
type: Species
boundary condition: true
constant: false
name: NDUFB7
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4713
has only substance units: false

metaR RE3421R
product: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
is: SBO:0000176
kinetic law: MODEL1310110053#
reversible: true
name: RE3421
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
is described by: ECO:0000000
type: Reaction

metaM thcrm hs g
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:24636
is: SBO:0000247
name: trihexosyl ceramide
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0

metaM m7mpdol U r
boundary condition: false
notes: FORMULA: C1665H2740N20O570P20 CHARGE: -20
type: Species
initial concentration: 1.0
initial amount: NaN
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: CHEBI:37636
is: SBO:0000247
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_38af9075_5a65_407d_94f9_5d87cb800722
type: Species
initial concentration: NaN
name: _728226_1_e
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:728226

http://identifiers.org/biomodels.db/MODEL1310110053#_6fa06741_5063_4119_9be7_b0e2cadb344f
name: SLC35D1
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:23169
boundary condition: true
has only substance units: false
is: Q9NTN3
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_ac75b138_92c1_4dbf_a6ef_ba1a592526c7
is encoded by: hsa:4715
is: Q9Y6M9
initial amount: NaN
constant: false
name: NDUFB9
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN

metaR r2127
product: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110053#

metaR SUCOASm
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.5
modifier: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
name: Succinate--CoA ligase (ADP-forming)
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction

metaR O2t
type: Reaction
fast: false
product: MODEL1310110053#
is: SBO:0000185
kinetic law: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
name: o2 transport (diffusion)
reactant: MODEL1310110053#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_e960ad6d_fc44_442b_846d_b122fd4b2248
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: GSTZ1
type: Species
is encoded by: hsa:2954
is: SBO:0000252
boundary condition: true

metaR r0679
product: MODEL1310110053#
reversible: true
type: Reaction
reactant: MODEL1310110053#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
is described by: ECO:0000000

metaR HISSNAT5tc
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM CE5236 n
initial concentration: 1.0
type: Species
has only substance units: false
name: O2'-4a-cyclic-tetrahydrobiopterin
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: SBO:0000247
is: CHEBI:28002
is: HMDB03952

http://identifiers.org/biomodels.db/MODEL1310110053#_e3255a12_6bc0_4794_85c6_4a0597fb1373
has only substance units: false
is: SBO:0000252
is encoded by: hsa:116369
initial concentration: NaN
name: SLC26A8
is: Q96RN1
initial amount: NaN
type: Species
boundary condition: true
constant: false

metaR NRPPHRt4 2 r
is: SBO:0000185
is described by: ECO:0000269
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110053#
name: Norepinephrine reversible transport in via sodium symport (1:2)
reactant: MODEL1310110053#
product: MODEL1310110053#
reversible: true
modifier: MODEL1310110053#

metaM ile L m
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
boundary condition: false
is: HMDB00172
initial concentration: 1.0
type: Species
is: CHEBI:17191
constant: false
name: L-isoleucine
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_a37f83fe_18ea_4116_94bb_b69abbebe2cd
is encoded by: hsa:10164
is: Q8NCG5
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
name: CHST4

http://identifiers.org/biomodels.db/MODEL1310110053#_c4f9f88b_474a_416b_b9c0_4603dd62d451
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:8574
name: AKR7A2
boundary condition: true
has only substance units: false
initial concentration: NaN
is: O43488
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_a13b11fd_5a72_40aa_a562_16f659cbf6e9
boundary condition: true
name: UGP2
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:7360
has only substance units: false

metaM ksii core2 pre2 g
type: Species
is: SBO:0000247
is: CHEBI:58053
notes: FORMULA: C39H63N3O28X CHARGE: -1
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 2
constant: false
boundary condition: false
is: C00130
has only substance units: false
initial concentration: 1.0
is: HMDB00175

http://identifiers.org/biomodels.db/MODEL1310110053#_de71c18f_ef51_4f3b_9f71_3a83a5868cec
initial concentration: NaN
name: PYCRL
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:65263
is: SBO:0000252
type: Species
is: Q53H96

http://identifiers.org/biomodels.db/MODEL1310110053#_77f044a1_825f_48de_92eb_9eb8fc07c427
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
name: ECI2
is: O75521
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10455
constant: false

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_d9abdb24_7054_4734_a97a_d60ae75856ee
is: SBO:0000252
is: Q9P212
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:51196
constant: false
name: PLCE1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_c35b51ee_0734_42c9_9192_159793738c0d
name: BCKDHB
is: P21953
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:594

http://identifiers.org/biomodels.db/MODEL1310110053#_e67e025e_6aa5_46ba_a3bf_f39a633278f8
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AA419122
has only substance units: false
name: _AA419122_1_c
type: Species
initial concentration: NaN
constant: false
initial amount: NaN

metaM citr L c
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00904
name: L-citrulline
initial concentration: 1.0
type: Species
is: CHEBI:16349
initial amount: NaN
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
boundary condition: false

metaR r0464
is described by: ECO:0000000
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
kinetic law: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_05cf4e46_c1e1_4584_90bf_c14f212d859c
is encoded by: hsa:5335
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: PLCG1
type: Species
is: Q9UFY1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_ae89eeab_3fca_4b11_8779_c2646fce10dc
initial concentration: NaN
is encoded by: hsa:5337
constant: false
has only substance units: false
boundary condition: true
type: Species
name: PLD1
is: SBO:0000252
initial amount: NaN
is: Q59EA4

metaR CBASPte
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110053#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of N-carbamoyl-L-aspartate

metaM dgsn e
boundary condition: false
name: Deoxyguanosine
constant: false
is: HMDB00085
type: Species
is: CHEBI:17172
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: C00330
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR ADEt
is: SBO:0000185
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true
name: adenine reversible transport, cytosol
product: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
is described by: ECO:0000269
fast: false

metaM pail hs n
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
initial amount: NaN
is: SBO:0000247
is: CHEBI:57880
constant: false
has only substance units: false
boundary condition: false
type: Species
name: 1-phosphatidyl-1D-myo-inositol(1-)
initial concentration: 1.0

metaR r2129
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110053#
product: MODEL1310110053#
reversible: true
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
fast: false

metaM man6p c
initial concentration: 1.0
is: SBO:0000247
name: D-Mannose 6-phosphate
is: CHEBI:17369
is: HMDB01078
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
type: Species
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false

metaM betald c
is: HMDB01252
initial concentration: 1.0
name: betaine aldehyde
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
constant: false
type: Species
initial amount: NaN
is: CHEBI:15710
has only substance units: false

metaR ACt2m
reversible: true
product: MODEL1310110053#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
name: acetate mitochondrial transport via proton symport

metaR DHFR
reversible: true
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
is: SBO:0000176
is described by: ECO:0000254
name: dihydrofolate reductase
product: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:

metaR 4NPHte
kinetic law: MODEL1310110053#
is: SBO:0000185
reactant: MODEL1310110053#
reversible: true
type: Reaction
name: xenobiotic transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
is described by: ECO:0000000
product: MODEL1310110053#
fast: false

metaR r2310
reversible: true
type: Reaction
kinetic law: MODEL1310110053#
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110053#
reactant: MODEL1310110053#

metaM citr L e
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00904
type: Species
boundary condition: false
name: citr_L[e]
is: CHEBI:16349
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial concentration: 1.0
constant: false

metaR r2537
is: SBO:0000185
reactant: MODEL1310110053#
reversible: true
kinetic law: MODEL1310110053#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110053#
type: Reaction
name: Utilized transport

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_cd71a955_1469_43da_a509_064acfccd178
initial concentration: NaN
has part: E9KL44
is encoded by: hsa:3030
initial amount: NaN
boundary condition: true
is encoded by: hsa:3032
type: Species
is: SBO:0000297
name: HADHA:HADHB
has only substance units: false
has part: P55084
constant: false

metaM retinol 9 cis c
initial concentration: 1.0
is: CHEBI:17336
name: 9-cis-retinol
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
boundary condition: false
is: HMDB06217
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_0e2b7746_cd84_4e00_98f5_d2c1f2319881
is: O95861
is encoded by: hsa:10380
name: BPNT1
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_68bc8396_eadc_4866_8c46_058a4b4e4d3e
initial concentration: NaN
is encoded by: hsa:1719
has only substance units: false
type: Species
constant: false
is: P00374
is: SBO:0000252
name: DHFR
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_a72c4308_4ba8_45df_8aab_85f001099e79
is: Q15111
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: PLCL1
is encoded by: hsa:5334
boundary condition: true
initial concentration: NaN

metaM utp c
is: C00075
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00285
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: CHEBI:46398
name: UTP
is: SBO:0000247

metaR ACONTm
fast: false
type: Reaction
name: Aconitate hydratase
product: MODEL1310110053#
is: SBO:0000176
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
kinetic law: MODEL1310110053#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.3
is described by: ECO:0000134
modifier: MODEL1310110053#

metaR HDCAter
kinetic law: MODEL1310110053#
type: Reaction
fast: false
reversible: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110053#
name: palmitate ER export
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM HC01104 e
name: 4-nitrophenyl phosphate(2-)
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:61146
initial amount: NaN
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
constant: false
is: SBO:0000247

metaM prostgd2 c
initial amount: NaN
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: HMDB01403
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57406
name: prostaglandin D2(1-)
has only substance units: false
type: Species

metaR G14T14g
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
modifier: MODEL1310110053#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90

http://identifiers.org/biomodels.db/MODEL1310110053#_4e086379_09e5_4b9b_a38d_552fa48e4686
initial amount: NaN
initial concentration: NaN
constant: false
is: Q96G03
name: PGM2
is encoded by: hsa:55276
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_e5bbf1ca_b7e4_40bc_a31a_cb60e229c81e
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q15274
initial amount: NaN
is encoded by: hsa:23475
type: Species
boundary condition: true
has only substance units: false
name: QPRT

metaM hs deg24 l
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C31H50NO26 CHARGE: -1
constant: false
initial concentration: 1.0
name: GlcNAc-GlcA-(Gal)2-Xyl
is: CHEBI:16126

metaR DURAD
modifier: MODEL1310110053#
is described by: ECO:0000269
type: Reaction
reversible: true
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
fast: false
name: dihydrouracil dehydrogenase (NADP)
kinetic law: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.2
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_d58f5057_d3fa_41a1_b220_0d895d1a2002
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:54963
is: Q53HM1
boundary condition: true
constant: false
name: UCKL1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_d0437116_68e6_4aed_a9b4_8a0170e90875
initial concentration: NaN
initial amount: NaN
is: Q92959
is: SBO:0000252
has only substance units: false
name: SLCO2A1
is encoded by: hsa:6578
boundary condition: true
constant: false
type: Species

metaM btn c
is: SBO:0000247
is: C00120
type: Species
is: HMDB00030
is: CHEBI:3420
boundary condition: false
name: Biotin
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H15N2O3S CHARGE: -1
has only substance units: false

metaR DOPASFt
is described by: ECO:0000000
product: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110053#
name: Dopamine 3-0-sulfate transport (diffusion)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
reversible: false

metaM 10fthf m
boundary condition: false
initial concentration: 1.0
is: CHEBI:57454
constant: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
has only substance units: false
name: 10-formyltetrahydrofolate(2-)
type: Species
is: SBO:0000247
is: HMDB00972
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_5504d5e3_ac76_4bc1_ad96_fc10ce74bc1a
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: A8K7J7
constant: false
type: Species
name: HK1
has only substance units: false
is encoded by: hsa:3098
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_c8147d0a_509e_43c0_b682_cfe7fefade54
constant: false
has part: Q86U05
name: SLC7A8:SLC3A2
has only substance units: false
initial amount: NaN
is: SBO:0000297
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:23428

http://identifiers.org/biomodels.db/MODEL1310110053#_07aadfcc_56a2_4e48_9456_38dffd1e23ac
is: SBO:0000252
type: Species
has only substance units: false
is: Q96QE2
name: SLC2A13
constant: false
initial concentration: NaN
is encoded by: hsa:114134
boundary condition: true
initial amount: NaN

metaR MALTSULtm
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
fast: false
reversible: true
name: Malate:thiosulfate antiport, mitochondrial
type: Reaction
modifier: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110053#_e8b02f2a_c28c_462f_a603_d350cff14c5b
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
name: _8781_1_c
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:8781

metaM 5adtststerone r
has only substance units: false
type: Species
name: 17beta-hydroxy-5alpha-androstan-3-one
is: HMDB02961
initial concentration: 1.0
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: CHEBI:16330
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false

metaR r2312
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
fast: false
reactant: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110053#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction

metaR r0686
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is version of: http://identifiers.org/ec-code/2.3.2.2
product: MODEL1310110053#
is described by: ECO:0000000
modifier: MODEL1310110053#
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110053#
reversible: true
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12

metaR r2535
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110053#
reversible: true
is: SBO:0000185
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
product: MODEL1310110053#
is described by: ECO:0000000
type: Reaction

metaR C226CPT2
product: MODEL1310110053#
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
name: C226 transport into the mitochondria
modifier: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_cda99631_f9c2_4828_b7bd_27591b908d2a
initial concentration: NaN
is encoded by: hsa:5337
is: Q59EA4
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
name: PLD1
has only substance units: false
boundary condition: true

metaM sphs1p r
name: sphingosine 1-phosphate(1-)
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: CHEBI:60119
has only substance units: false
is: SBO:0000247
is: HMDB00277
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_e6404cba_648c_422a_ba79_3f9447231b45
type: Species
initial concentration: NaN
name: NDUFS3
has only substance units: false
is encoded by: hsa:4722
constant: false
is: O75489
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_59d082b0_ed28_45fb_86ed_6d0e9a75b78e
name: DLAT
is: SBO:0000252
is encoded by: hsa:1737
is: Q86YI5
boundary condition: true
type: Species
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

metaM ksii core2 g
is: HMDB00189
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
initial concentration: 1.0
is: CHEBI:57614
has only substance units: false
name: keratan sulfate II (core 2-linked)

metaM prostgd2 e
is: HMDB01403
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: CHEBI:57406
type: Species
name: prostaglandin D2(1-)
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_20056cb7_8fcc_454a_a85d_f884a2a1f029
has only substance units: false
constant: false
is encoded by: hsa:6390
name: SDHB
type: Species
initial amount: NaN
initial concentration: NaN
is: P21912
boundary condition: true
is: SBO:0000252

metaM cholp c
name: choline phosphate(1-)
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: CHEBI:295975
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_e7cc6a1d_5af9_4be4_9dfa_dea41e9a35a4
is: SBO:0000252
is: Q9NVE7
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
name: PANK4
type: Species
is encoded by: hsa:55229
boundary condition: true

metaR ACGAMK
reversible: false
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
name: N-acetylglucosamine kinase
is: SBO:0000176
reactant: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.59
type: Reaction
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
fast: false

metaR r2311
is: SBO:0000185
kinetic law: MODEL1310110053#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
fast: false
reactant: MODEL1310110053#
product: MODEL1310110053#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction

metaR 4MOPt2im
reversible: false
kinetic law: MODEL1310110053#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
is: SBO:0000185
fast: false
reactant: MODEL1310110053#
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
product: MODEL1310110053#
type: Reaction

metaR GCC2bim
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/2.1.2.10
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
reversible: false
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.4.4.2
type: Reaction
fast: false
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110053#_8a9cf8bd_6289_4539_adf7_173358e5c029
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:AI024818
initial concentration: NaN
is: SBO:0000252
name: _AI024818_1_c

metaR r0970
reversible: true
name: Active transport
type: Reaction
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
product: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000000

metaR C226CPT1
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
is described by: ECO:0000000
name: carnitine C22:6 transferase
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110053#
is: SBO:0000176
modifier: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR RE3568C
name: RE3568
reversible: true
reactant: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
product: MODEL1310110053#

metaM HC02216 c
constant: false
initial concentration: 1.0
name: prostaglandin-f2beta
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:28922

http://identifiers.org/biomodels.db/MODEL1310110053#_11b35a13_9c87_4d84_addb_e30b5c7a2812
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: CA3
is: SBO:0000252
is encoded by: hsa:761
is: P07451
initial concentration: NaN
type: Species

metaR 34DHXMANDACOX
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
product: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
kinetic law: MODEL1310110053#
is: SBO:0000176
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
is described by: ECO:0000269
reactant: MODEL1310110053#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_08232978_c4df_472f_b527_108ef8b67e39
is: SBO:0000252
boundary condition: true
is: Q15392
initial amount: NaN
initial concentration: NaN
name: DHCR24
has only substance units: false
constant: false
is encoded by: hsa:1718
type: Species

metaR r0680
is: SBO:0000176
modifier: MODEL1310110053#
type: Reaction
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.137
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_39533b48_8781_4e3a_bb32_cb5bff4e0eee
name: ETNK1
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is: Q9HBU6
boundary condition: true
is: SBO:0000252
is encoded by: hsa:55500

http://identifiers.org/biomodels.db/MODEL1310110053#_ae29dd16_5f24_4ad2_af55_1ab56a345c74
constant: false
is: Q5QPH3
is encoded by: hsa:55902
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: ACSS2

metaM CE2435 m
is: SBO:0000247
initial concentration: 1.0
name: trans,cis-deca-2,4-dienoyl-CoA
has only substance units: false
is: C01936
initial amount: NaN
type: Species
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/5041

metaR SBT Dtde
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
kinetic law: MODEL1310110053#
reversible: true
is described by: ECO:0000134
is: SBO:0000185
type: Reaction
reactant: MODEL1310110053#
fast: false
product: MODEL1310110053#
name: D-sorbitol transport, extracellular

http://identifiers.org/biomodels.db/MODEL1310110053#_9e74605f_399f_4618_bc71_ed026bc81fb3
initial concentration: NaN
is: P30838
name: ALDH3A1
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:218

http://identifiers.org/biomodels.db/MODEL1310110053#_2b3bff93_f133_4f59_bcd3_d41d04681644
initial concentration: NaN
initial amount: NaN
is: Q9HAS3
name: SLC28A3
boundary condition: true
type: Species
constant: false
is encoded by: hsa:64078
is: SBO:0000252
has only substance units: false

metaM digalsgalside hs e
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
is: http://identifiers.org/pubchem.compound/8384
has only substance units: false
initial amount: NaN
constant: false
name: Digalactosylceramidesulfate
is: C06127
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaM 4fumacac c
initial concentration: 1.0
is: CHEBI:18034
name: 4-fumarylacetoacetate(2-)
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
is: HMDB01268
type: Species
initial amount: NaN

metaR ACt2r
is described by: ECO:0000000
fast: false
type: Reaction
name: acetate reversible transport via proton symport
reactant: MODEL1310110053#
is: SBO:0000185
reversible: true
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
kinetic law: MODEL1310110053#

metaM fad e
has only substance units: false
is: C00016
initial concentration: 1.0
is: HMDB01248
name: Flavin adenine dinucleotide oxidized
initial amount: NaN
constant: false
is: CHEBI:16238
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: SBO:0000247
boundary condition: false
type: Species

metaM 3ohdcoa m
type: Species
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
constant: false
is: HMDB06402
initial concentration: 1.0
name: 3-oxopalmitoyl-CoA(4-)
is: CHEBI:57349
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR MECOALm
is version of: http://identifiers.org/ec-code/6.2.1.4
modifier: MODEL1310110053#
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
is described by: ECO:0000212
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
type: Reaction
reversible: true
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.5

metaR RETt
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
product: MODEL1310110053#
reversible: false
kinetic law: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110053#
name: Retinol transport via faciliated diffusion

metaR GCC2cm
kinetic law: MODEL1310110053#
reversible: true
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.1.2.10
product: MODEL1310110053#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.4.4.2
modifier: MODEL1310110053#
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.4
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
name: glycine-cleavage complex (lipoamide), mitochondrial
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110053#_7c14ce3d_55d6_4c0c_822c_97d11f49cb2e
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
name: SULT1A1
boundary condition: true
constant: false
is encoded by: hsa:6817
is: SBO:0000252

metaR r2120
is described by: ECO:0000000
product: MODEL1310110053#
modifier: MODEL1310110053#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110053#

metaM chlstol r
name: 5alpha-cholesta-7,24-dien-3beta-ol
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
boundary condition: false
has only substance units: false
is: CHEBI:16290
constant: false
initial amount: NaN
is: HMDB06842

http://identifiers.org/biomodels.db/MODEL1310110053#_d1d3d0c6_9968_4685_9863_c5ea4acb9a5b
initial concentration: NaN
is: Q6P9G0
boundary condition: true
is encoded by: hsa:124637
has only substance units: false
initial amount: NaN
name: CYB5D1
is: SBO:0000252
constant: false
type: Species

metaR DM ethamp r
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaM ile L c
is: CHEBI:17191
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00172
boundary condition: false
is: SBO:0000247
constant: false
name: L-isoleucine

metaR r2534
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaR TMDK1m
reversible: false
product: MODEL1310110053#
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110053#
name: thymidine kinase (ATP:thymidine)
is version of: http://identifiers.org/ec-code/2.7.1.21
fast: false
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:9342341 NOTES:TV
kinetic law: MODEL1310110053#
type: Reaction

metaR MI14PP
fast: false
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
is: SBO:0000176
product: MODEL1310110053#
modifier: MODEL1310110053#
name: inositol-1,4-bisphosphate 1-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.57
reactant: MODEL1310110053#
is described by: ECO:0000269
kinetic law: MODEL1310110053#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_d8de754d_c3d1_493c_93f3_c5dd224ee216
type: Species
initial amount: NaN
is: SBO:0000252
is: Q15147
has only substance units: false
is encoded by: hsa:5332
constant: false
boundary condition: true
name: PLCB4
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_426555ad_c61c_4a69_ba63_09476c4b4bbd
constant: false
name: _AL048840_1_c
is encoded by: hsa:AL048840
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species

metaR SUCCTD
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

metaM glyc R c
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00139
boundary condition: false
has only substance units: false
name: D-glycerate
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: CHEBI:16659
type: Species
initial amount: NaN

metaR ALAtN1
type: Reaction
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
name: Alanine transport (Na, H coupled)
is: SBO:0000185
is described by: ECO:0000269
reversible: true
fast: false
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110053#

metaM HC02216 e
is: SBO:0000247
is: CHEBI:28922
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
name: prostaglandin-f2beta
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
type: Species

metaM clpndcoa x
is: HMDB06267
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
is: SBO:0000247
type: Species
is: C16166
constant: false
has only substance units: false
name: clupanodonyl CoA
is: http://identifiers.org/pubchem.compound/47205476
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_85997394_71d2_4360_9b4c_e9462f06fa79
boundary condition: true
constant: false
type: Species
is encoded by: hsa:57835
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: SLC4A5
has only substance units: false

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaR r2121
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true
product: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaR r0973
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110053#
is: SBO:0000185
type: Reaction
product: MODEL1310110053#
fast: false
name: Facilitated diffusion

http://identifiers.org/biomodels.db/MODEL1310110053#_ed7b1756_d3dd_4f46_be3a_2076349044de
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:55349
initial concentration: NaN
initial amount: NaN
is: Q8NE62
name: CHDH
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_bac3c3c0_cd45_4c25_8c76_1cf2ea888190
is: Q14542
type: Species
constant: false
is encoded by: hsa:3177
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: SLC29A2
has only substance units: false
initial amount: NaN

metaR DOLPGT1 Uer
product: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110053#
is: SBO:0000176
fast: false
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
is version of: http://identifiers.org/ec-code/2.4.1.267
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10359825 NOTES:EC 2.4.1.- NCD
modifier: MODEL1310110053#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110053#_7f5497c0_b9dd_4bbc_b651_2105e01b6b3f
name: GCK
boundary condition: true
is encoded by: hsa:2645
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_eeab7988_91c8_4e92_b211_8e80c583294f
initial amount: NaN
name: GMPPA
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q96IJ6
is encoded by: hsa:29926
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_d7a80b77_c52a_448e_adcc_5781c8f5c8da
is: SBO:0000252
is encoded by: hsa:10166
initial concentration: NaN
boundary condition: true
has only substance units: false
name: SLC25A15
is: Q9Y619
constant: false
initial amount: NaN
type: Species

metaR DHORTS
kinetic law: MODEL1310110053#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.3.2
reversible: true
name: dihydroorotase
is described by: ECO:0000269
modifier: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:

metaR CHOLtn
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
type: Reaction
kinetic law: MODEL1310110053#
is: SBO:0000185
reactant: MODEL1310110053#
fast: false
name: Choline transport, nuclear through pores
product: MODEL1310110053#
reversible: true

metaM citr L m
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
type: Species
is: SBO:0000247
is: CHEBI:16349
has only substance units: false
initial amount: NaN
name: L-citrulline
constant: false
boundary condition: false
is: HMDB00904

http://identifiers.org/biomodels.db/MODEL1310110053#_9de51b4d_4b68_48a0_91be_a9dce30170f4
has only substance units: false
type: Species
initial concentration: NaN
name: NDUFS1
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4719
is: P28331

http://identifiers.org/biomodels.db/MODEL1310110053#_1c6b536f_da03_4aed_8b75_3e106bfd43ef
initial amount: NaN
boundary condition: true
is: P23921
is encoded by: hsa:6240
type: Species
initial concentration: NaN
name: RRM1
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_9db407d1_6e1a_402a_abb5_521ae0a2fb28
is encoded by: hsa:2589
boundary condition: true
name: GALNT1
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q10472

metaM fad c
is: C00016
initial concentration: 1.0
name: Flavin adenine dinucleotide oxidized
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: HMDB01248
is: CHEBI:16238
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
type: Species

metaM digalsgalside hs c
is: SBO:0000247
has only substance units: false
name: Digalactosylceramidesulfate
is: http://identifiers.org/pubchem.compound/8384
initial amount: NaN
constant: false
boundary condition: false
is: C06127
type: Species
initial concentration: 1.0
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127

metaR r2122
reactant: MODEL1310110053#
product: MODEL1310110053#
modifier: MODEL1310110053#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110053#

metaM btn e
type: Species
is: C00120
is: SBO:0000247
is: HMDB00030
is: CHEBI:3420
constant: false
initial amount: NaN
notes: FORMULA: C10H15N2O3S CHARGE: -1
boundary condition: false
name: Biotin
has only substance units: false
initial concentration: 1.0

metaR r0974
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
type: Reaction
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000185
name: Active transport
product: MODEL1310110053#
is described by: ECO:0000000
fast: false
reversible: true

metaR r2532
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110053#_c71cdc44_b662_41fb_8c67_dc2bdada27e3
constant: false
name: HK2
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is: P52789
initial amount: NaN
is encoded by: hsa:3099

http://identifiers.org/biomodels.db/MODEL1310110053#_2cf7c5b1_3a38_4cf6_bde4_ad89311fc35c
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:56606
name: SLC2A9

metaR AGDC
name: N-acetylglucosamine-6-phosphate deacetylase
modifier: MODEL1310110053#
reversible: false
product: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51005.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.1.25 Confidence Level: 2 AUTHORS: NOTES:acetylglucosamine phosphate deacetylase; acetylaminodeoxyglucosephosphate acetylhydrolase; 2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase
type: Reaction
is described by: ECO:0000254
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.5.1.25
fast: false

metaR r0683
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
fast: false
modifier: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
type: Reaction
reactant: MODEL1310110053#
is: SBO:0000176
product: MODEL1310110053#

metaM ile L e
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:17191
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: HMDB00172
initial concentration: 1.0
type: Species
name: L-isoleucine
initial amount: NaN

metaR ARACHDCOAtx
reversible: true
is: SBO:0000185
name: fatty acid intracellular transport
is described by: ECO:0000000
fast: false
product: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
kinetic law: MODEL1310110053#

metaM etha c
boundary condition: false
type: Species
is: CHEBI:57603
name: etha[c]
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C2H8NO CHARGE: 1 INCHI: InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00180 EHMN_ABBREVIATION: C00189
has only substance units: false
is: HMDB00149
initial concentration: 1.0
constant: false

metaR r2318
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110053#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM ksi pre24 g
is: C00130
has only substance units: false
boundary condition: false
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
name: keratan sulfate I biosynthesis, precursor 24
initial amount: NaN
is: CHEBI:58053
is: HMDB00175
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR r1007
fast: false
type: Reaction
name: Facilitated diffusion
reversible: true
product: MODEL1310110053#
is: SBO:0000185
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110053#

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR CHOLtr
is described by: ECO:0000000
name: choline intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110053#
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110053#
reversible: true
product: MODEL1310110053#

metaR r0975
reactant: MODEL1310110053#
product: MODEL1310110053#
name: Facilitated diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110053#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110053#_100c4a42_0314_437e_b61b_03a71ae69d69
is: SBO:0000252
boundary condition: true
type: Species
name: ADSL
initial amount: NaN
is: P30566
initial concentration: NaN
constant: false
is encoded by: hsa:158
has only substance units: false

metaM pro D c
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
has only substance units: false
is: HMDB03411
initial concentration: 1.0
is: CHEBI:16313
name: D-proline
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_22c8a2e7_ac84_4136_9641_e0669af81543
constant: false
has only substance units: false
boundary condition: true
is: O75452
name: RDH16
initial concentration: NaN
is encoded by: hsa:8608
is: SBO:0000252
type: Species
initial amount: NaN

metaR r0940
type: Reaction
reactant: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
name: Free diffusion
kinetic law: MODEL1310110053#
fast: false
is described by: ECO:0000000
product: MODEL1310110053#

metaR ATPtx
type: Reaction
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
name: ATP transporter, peroxisomal

metaM HC02180 e
type: Species
name: thromboxane-b2
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
constant: false
is: CHEBI:28728
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM pac c
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
is: CHEBI:18401
boundary condition: false
is: HMDB00209
initial concentration: 1.0
name: phenylacetate
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false

metaR r1715
product: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110053#
name: Y+LAT2 Utilized transport
reversible: false
fast: false
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110053#_510840f4_8b33_40ab_b4a2_fdf82103020a
initial amount: NaN
constant: false
is encoded by: hsa:AI345944
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
name: _AI345944_1_m
initial concentration: NaN

metaR r2317
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110053#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110053#_ca7fce80_fbea_4bbb_ace4_73a9e995203b
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: A5PKZ1
boundary condition: true
is: SBO:0000252
name: GALNT5
is encoded by: hsa:11227

metaR ALAGLYexR
reversible: true
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000304
name: L-alanine/glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
modifier: MODEL1310110053#
product: MODEL1310110053#
type: Reaction

metaR ILETA
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
reactant: MODEL1310110053#
modifier: MODEL1310110053#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
type: Reaction
product: MODEL1310110053#
name: isoleucine transaminase
kinetic law: MODEL1310110053#
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110053#_97150711_a628_4e4c_8d00_88a58cc98522
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:221
constant: false
name: ALDH3B1
initial amount: NaN
is: P43353
initial concentration: NaN

metaR ITPtn
product: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true
is described by: ECO:0000000
type: Reaction
name: ITP nuclear transport

http://identifiers.org/biomodels.db/MODEL1310110053#_a301e98d_5f62_41cc_bd8a_e9719be99969
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8704
has only substance units: false
constant: false
initial amount: NaN
name: B4GALT2

metaM glu L m
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: HMDB00148
boundary condition: false
is: CHEBI:29985
name: L-glutamate(1-)
is: SBO:0000247
initial amount: NaN
constant: false

metaR RE1845X
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
type: Reaction
name: RE1845
reactant: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_9ddd0d6a_168e_4b9c_8d92_48c384471209
is encoded by: hsa:8704
boundary condition: true
name: B4GALT2
has only substance units: false
initial amount: NaN
constant: false
is: O60909
initial concentration: NaN
type: Species
is: SBO:0000252

metaR DGK1
type: Reaction
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110053#
modifier: MODEL1310110053#
reactant: MODEL1310110053#
name: deoxyguanylate kinase (dGMP:ATP)
is version of: http://identifiers.org/ec-code/2.7.4.8
fast: false
reversible: true
kinetic law: MODEL1310110053#
is described by: ECO:0000269
is: SBO:0000176

metaR r0942
reactant: MODEL1310110053#
is: SBO:0000185
reversible: true
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
fast: false
kinetic law: MODEL1310110053#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
product: MODEL1310110053#
type: Reaction

metaR S6T3g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
modifier: MODEL1310110053#
is: SBO:0000176
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.8.2.17
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.8.2.21
is described by: ECO:0000000
reactant: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
reversible: false

metaR MTHFCm
product: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.3
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.4.9
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
kinetic law: MODEL1310110053#
reversible: true
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110053#_10d8fac5_e2e2_4c1c_8490_43c76fabbae8
type: Species
is: SBO:0000252
name: _BC005314_1_x
is encoded by: hsa:BC005314
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_c9b2c6a6_6673_4086_8bb7_8ee912037fa7
is: Q9H2U2
is: SBO:0000252
name: PPA2
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:27068
constant: false
initial concentration: NaN

metaM HC02180 c
type: Species
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
name: thromboxane-b2
has only substance units: false
is: CHEBI:28728
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR GLCNACASE5ly
is described by: ECO:0000000
kinetic law: MODEL1310110053#
fast: false
reversible: false
name: alpha-N-acetylglucosaminidase, lysosomal
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.2.1.50
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110053#
product: MODEL1310110053#
type: Reaction

metaM pro D e
constant: false
type: Species
boundary condition: false
name: D-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
initial amount: NaN
has only substance units: false
is: CHEBI:16313
is: HMDB03411
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_f2f08980_c50a_4227_820d_761087fd3732
name: ALDOB
initial amount: NaN
is: SBO:0000252
is: P05062
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:229
initial concentration: NaN
constant: false

metaR r1008
is: SBO:0000185
reversible: false
product: MODEL1310110053#
name: Facilitated diffusion
type: Reaction
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
is described by: ECO:0000000

metaR LEUKTRA4t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
is described by: ECO:0000269
name: leukotriene A4 transport
kinetic law: MODEL1310110053#
reversible: true
product: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_8cb316d8_a989_4bab_8a6f_528c431ece60
is: A8K5Z0
type: Species
name: B4GALT3
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8703
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_dc4e1cd9_eacf_434a_a04a_35caa5ede765
is: SBO:0000252
initial concentration: NaN
is: Q9BYZ2
constant: false
type: Species
is encoded by: hsa:92483
has only substance units: false
initial amount: NaN
name: LDHAL6B
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_fed609ec_35d4_425f_85e3_ecb96d4306e5
constant: false
initial concentration: NaN
name: ST3GAL3
boundary condition: true
is encoded by: hsa:6487
type: Species
is: SBO:0000252
has only substance units: false
is: Q5T4W8
initial amount: NaN

metaM paps c
type: Species
boundary condition: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
is: CHEBI:58339
initial concentration: 1.0
is: HMDB01134
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053

metaR r1939
kinetic law: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185

metaM HC01376 m
type: Species
initial concentration: 1.0
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
is: CHEBI:28692
constant: false
boundary condition: false
name: S-(2-Methylbutanoyl)-dihydrolipoamide
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR r0941
product: MODEL1310110053#
name: Free diffusion
reactant: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110053#
fast: false
type: Reaction
reversible: true

metaR FUMTSULtm
product: MODEL1310110053#
modifier: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110053#
name: Fumarate:thiosulfate antiport, mitochondrial
is described by: ECO:0000269
kinetic law: MODEL1310110053#

metaR r2319
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000000
fast: false
product: MODEL1310110053#
type: Reaction
is: SBO:0000185

metaR AICARte
product: MODEL1310110053#
is described by: ECO:0000134
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000185
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM digalsgalside hs g
initial concentration: 1.0
is: C06127
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/8384
name: Digalactosylceramidesulfate
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_82ec03cc_0116_4d17_a46b_8deb678d2bd4
has only substance units: false
is: B4DIA3
name: SLC6A8
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:6535
is: SBO:0000252

metaM HC02203 c
initial amount: NaN
is: CHEBI:27820
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
is: SBO:0000247
constant: false
name: prostaglandin-a2

metaR RAI2
product: MODEL1310110053#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110053#
name: retinal isomerase (9-cis)
fast: false
reactant: MODEL1310110053#

metaM HC00342 c
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial amount: NaN
type: Species
name: cis-aconitate(3-)
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:16383
initial concentration: 1.0
is: SBO:0000247

metaR FAOXC200180m
is: SBO:0000176
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110053#
reversible: false
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110053#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1

metaR r1656
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110053#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110053#
fast: false

metaR r2314
fast: false
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110053#
is: SBO:0000185
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110053#

metaR RDH3
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
modifier: MODEL1310110053#
name: retinol dehydrogenase (11-cis,NADH)
product: MODEL1310110053#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.315
fast: false
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT

metaR r0944
fast: false
type: Reaction
name: Active transport
product: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
reactant: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaR FUMSO3tm
reactant: MODEL1310110053#
is: SBO:0000185
product: MODEL1310110053#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
name: Fumarate:sulfite antiport, mitochondrial
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#

metaM g1m8masn r
boundary condition: false
is: C05875
notes: FORMULA: C76H127N2O60X CHARGE: 0
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
constant: false
is: SBO:0000247

metaR MG3er
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
type: Reaction
reactant: MODEL1310110053#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000000
reversible: false
is: SBO:0000176

metaM Sfglutth c
type: Species
constant: false
is: CHEBI:57688
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB01550
name: S-formylglutathionate(1-)

metaR ADSL1
is described by: ECO:0000269
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/4.3.2.2
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
product: MODEL1310110053#
name: adenylosuccinate lyase
type: Reaction
is: SBO:0000176
fast: false
reversible: false
kinetic law: MODEL1310110053#

metaM ala L c
initial amount: NaN
name: L-alanine
type: Species
is: SBO:0000247
is: CHEBI:16977
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: HMDB00161
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false

metaR PROt4 2 r
kinetic law: MODEL1310110053#
is: SBO:0000185
reversible: true
product: MODEL1310110053#
name: Proline transport (sodium symport) (2:1)
fast: false
reactant: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000006

http://identifiers.org/biomodels.db/MODEL1310110053#_2f95cdf8_9db1_4cd8_997f_768b076a1b2c
name: _728226_1_m
initial concentration: NaN
type: Species
is encoded by: hsa:728226
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true

metaR ENGASE2ly
is: SBO:0000176
kinetic law: MODEL1310110053#
name: endo-beta-N-acetylglucosaminidase, lysosomal
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110053#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110053#

metaR EX digalsgalside hs LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Digalactosylceramidesulfate exchange
type: Reaction

metaR PCHOLPm hs
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.1.4.4
reactant: MODEL1310110053#
name: choline phosphatase
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
reversible: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
fast: false
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_d8a5475b_23bc_4399_99d1_8db11cdf3dda
initial concentration: NaN
is encoded by: hsa:10449
is: SBO:0000252
type: Species
is: P42765
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
name: ACAA2

metaR CYSGLTH
fast: false
kinetic law: MODEL1310110053#
reversible: true
is described by: ECO:0000000
name: Glutathione:cystine oxidoreductase
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
product: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_92cf32b6_6908_493e_8b6f_9b2cbd7b9aa8
name: CHAT
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: P28329
is: SBO:0000252
constant: false
is encoded by: hsa:1103
boundary condition: true

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_2a3d1a9b_50aa_4d38_9570_f74c8f8ec0f0
initial concentration: NaN
name: _NM_001929_1_c
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:NM 001929

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaR r1657
reactant: MODEL1310110053#
is: SBO:0000185
product: MODEL1310110053#
is described by: ECO:0000000
type: Reaction
reversible: true
modifier: MODEL1310110053#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM acmana c
constant: false
type: Species
boundary condition: false
name: N-acetyl-D-mannosamine
initial concentration: 1.0
is: CHEBI:17122
has only substance units: false
is: SBO:0000247
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
is: HMDB01129
initial amount: NaN

metaR CHOLtu
name: Choline uniport
is described by: ECO:0000269
reactant: MODEL1310110053#
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000185
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaM g3p c
has only substance units: false
is: C00661
is: HMDB01112
type: Species
is: CHEBI:58027
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
constant: false
name: Glyceraldehyde 3-phosphate
is: http://identifiers.org/pubchem.compound/3930
is: SBO:0000247

metaR r2313
type: Reaction
product: MODEL1310110053#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110053#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM ala L e
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:16977
name: L-alanine
constant: false
has only substance units: false
is: HMDB00161
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_db5e4f9b_097b_4386_801e_ef2c0884082c
constant: false
name: _206_1_c
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:206
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_41263547_e0c9_46f9_971c_8e16a33b5dbc
name: SLC5A9
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: E9PAK4
is: SBO:0000252
is encoded by: hsa:200010

http://identifiers.org/biomodels.db/MODEL1310110053#_67b53c8d_b58b_4d20_811e_be68f4d161e9
is: SBO:0000252
boundary condition: true
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: DEGS1
initial concentration: NaN
is encoded by: hsa:8560

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaM fad m
initial concentration: 1.0
is: HMDB01248
boundary condition: false
name: Flavin adenine dinucleotide oxidized
initial amount: NaN
constant: false
is: CHEBI:16238
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
type: Species
has only substance units: false
is: C00016
is: SBO:0000247

metaM HC02203 e
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
is: CHEBI:27820
name: prostaglandin-a2
type: Species
has only substance units: false
constant: false
is: SBO:0000247

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_0a3d295e_8642_4518_9b8d_473b8d2d0671
is: Q9H2B4
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:10861
name: SLC26A1

metaR r1658
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110053#
is described by: ECO:0000000
reversible: true
type: Reaction
modifier: MODEL1310110053#
is: SBO:0000185
product: MODEL1310110053#
fast: false

metaR S3TASE1ly
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
type: Reaction
name: N-acetylglucosamine-3-sulfatase, lysosomal
product: MODEL1310110053#
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110053#

metaR 3HBCOAHLm
reactant: MODEL1310110053#
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
is described by: ECO:0000000
product: MODEL1310110053#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
kinetic law: MODEL1310110053#
reversible: false
type: Reaction

metaR r2316
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110053#
kinetic law: MODEL1310110053#

metaM dhlam m
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
is: CHEBI:17694
is: SBO:0000247
boundary condition: false
is: HMDB00985
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: dihydrolipoamide

metaR r0946
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110053#
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_cc5a88a8_ac25_4912_850a_7f8d83706815
is: Q9BXI2
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
name: SLC25A2
is encoded by: hsa:83884
initial concentration: NaN

metaR RDH1
modifier: MODEL1310110053#
is described by: ECO:0000269
is: SBO:0000176
name: retinol dehydrogenase (all-trans)
type: Reaction
reactant: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.315
reversible: true
fast: false
kinetic law: MODEL1310110053#

metaR PMTCOAtx
reactant: MODEL1310110053#
type: Reaction
fast: false
name: fatty acid intracellular transport
is described by: ECO:0000000
reversible: true
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110053#
is: SBO:0000185

metaR 3DSPHR
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.1.1.102
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110053#
reversible: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110053#
reactant: MODEL1310110053#
name: 3-Dehydrosphinganine reductase
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110053#_e28e57eb_2593_447d_9e68_3c76cbe32411
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:11001
name: SLC27A2
has only substance units: false
is: SBO:0000252
type: Species
is: O14975

http://identifiers.org/biomodels.db/MODEL1310110053#_f5b76fdb_5d87_4f63_bf05_2a518dbeaf0a
constant: false
name: SCD
is encoded by: hsa:6319
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: O00767
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_29df1bb0_04ea_4e0f_855a_1d53b69bb79f
initial concentration: NaN
is: Q6P1K9
has only substance units: false
boundary condition: true
is encoded by: hsa:80025
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
name: PANK2

http://identifiers.org/biomodels.db/MODEL1310110053#_16cb4756_e2bf_4c83_8322_edcef78ddffc
name: AGPAT1
type: Species
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10554
is: Q99943
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_a87d9744_676a_4997_bd9e_e9ee2e8ffa9f
is: SBO:0000252
initial amount: NaN
is: O00624
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10246
has only substance units: false
name: SLC17A2

http://identifiers.org/biomodels.db/MODEL1310110053#_0e5c0a1d_00aa_4cd1_ba05_eadb283115fe
initial amount: NaN
name: UPP2
constant: false
boundary condition: true
has only substance units: false
is: O95045
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:151531

metaR r2315
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
reactant: MODEL1310110053#

metaR KSIt
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
reversible: false
is described by: ECO:0000000
product: MODEL1310110053#
name: keratan sulfate I transport, golgi to extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false

metaR r1659
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110053#
product: MODEL1310110053#
modifier: MODEL1310110053#

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaR S3TASE2ly
name: N-acetylglucosamine-3-sulfatase, lysosomal
kinetic law: MODEL1310110053#
is: SBO:0000176
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
reactant: MODEL1310110053#
fast: false
product: MODEL1310110053#

metaM C04849 e
has only substance units: false
initial amount: NaN
is: CHEBI:57449
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
type: Species
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_31ab7675_cce0_4489_a378_e5b57339c5d9
is: E9KL48
initial concentration: NaN
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: GLUD1
is: SBO:0000252
is encoded by: hsa:2746
boundary condition: true

metaR CSND
is described by: ECO:0000000
fast: false
reactant: MODEL1310110053#
reversible: false
type: Reaction
is: SBO:0000176
product: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
name: Cytosine deaminase

http://identifiers.org/biomodels.db/MODEL1310110053#_070aeedb_9e29_4120_bd4e_1c05edbccc7f
is encoded by: hsa:55312
type: Species
name: RFK
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is: B2RDZ2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_541062be_dc4b_44a5_ba1f_2a184d84ac7c
boundary condition: true
is: SBO:0000252
name: GGT5
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2687
is: P36269
constant: false
has only substance units: false

metaM pap g
initial concentration: 1.0
name: adenosine 3',5'-bismonophosphate(4-)
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:58343
boundary condition: false
type: Species
constant: false
is: HMDB00061

metaR FOLt2le
reversible: true
is described by: ECO:0000134
product: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110053#
type: Reaction
name: folate transport via anion exchange
fast: false
is: SBO:0000185

metaM tdcoa m
is: HMDB01521
is: SBO:0000247
is: C02593
boundary condition: false
name: Tetradecanoyl-CoA (n-C14:0CoA)
type: Species
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:57385
initial concentration: 1.0

metaR r0391
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
kinetic law: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_e2619d7b_b1a5_4002_a387_c67cb17c4f59
type: Species
initial concentration: NaN
is: E9KL44
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3030
constant: false
boundary condition: true
name: HADHA

metaR DURItn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
product: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110053#
is: SBO:0000185
kinetic law: MODEL1310110053#
name: deoxyuridine transport in nucleus
reversible: true

metaR RE1531M
reversible: true
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000176
name: RE1531
modifier: MODEL1310110053#
type: Reaction
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110053#

metaR RE1796M
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.145
name: RE1796
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
product: MODEL1310110053#
reversible: true
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000176
fast: false

metaM s7p c
type: Species
is: C05382
has only substance units: false
constant: false
is: CHEBI:57483
is: SBO:0000247
is: HMDB01068
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
boundary condition: false
name: Sedoheptulose 7-phosphate

metaR PI45P5P
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.36
modifier: MODEL1310110053#
product: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase

metaR DURIt
name: deoxyuridine transport via diffusion
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reactant: MODEL1310110053#
product: MODEL1310110053#
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_223159d3_3141_419f_bbb5_bfc86ff7c414
initial concentration: NaN
is: SBO:0000252
is: P27707
boundary condition: true
has only substance units: false
name: DCK
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:1633

http://identifiers.org/biomodels.db/MODEL1310110053#_777bf1f5_4d69_4231_a467_39e87d89f978
boundary condition: true
is encoded by: hsa:AI971036
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: _AI971036_1_x
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_7ce83b7f_83bd_47d7_881d_14fc848a5aa9
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:23428
name: SLC7A8:SLC3A2
initial concentration: NaN
type: Species
has part: Q9UHI5
is: SBO:0000297

metaR UMPKn
name: UMP kinase, nuclear
reactant: MODEL1310110053#
fast: false
reversible: true
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD

metaR r0472
reversible: true
fast: false
kinetic law: MODEL1310110053#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
product: MODEL1310110053#
is: SBO:0000176
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reactant: MODEL1310110053#

metaM coa m
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB01423
constant: false
is: C00010
name: Coenzyme A
is: CHEBI:57287
initial amount: NaN
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010

metaM rbt c
initial amount: NaN
constant: false
is: SBO:0000247
name: D-ribitol
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
initial concentration: 1.0
is: HMDB00508
has only substance units: false
type: Species
is: CHEBI:15963

metaR r0392
product: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true
is: SBO:0000176
fast: false
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
kinetic law: MODEL1310110053#

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaR URIK1
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.48
kinetic law: MODEL1310110053#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
fast: false
name: uridine kinase (ATP:Uridine)
product: MODEL1310110053#
modifier: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000176

metaR M7MASNBterg
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
name: m7masnB transport from endoplasmic reticulum to Golgi apparatus
product: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110053#

metaM l2fn2m2masn g
is: SBO:0000247
notes: FORMULA: C68H113N4O49X CHARGE: 0
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:28067
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine

http://identifiers.org/biomodels.db/MODEL1310110053#_d3e03f1d_a2af_4a7d_92ed_31ac03bcb3bd
is encoded by: hsa:11181
is: SBO:0000252
is: O43280
name: TREH
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_6b786563_cd3a_42f3_a868_8901f1ceedf1
is encoded by: hsa:1836
constant: false
has only substance units: false
initial amount: NaN
name: SLC26A2
boundary condition: true
is: SBO:0000252
is: P50443
initial concentration: NaN
type: Species

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

http://identifiers.org/biomodels.db/MODEL1310110053#_37a97015_c6cb_413d_ae8c_79408eb09c61
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:4952
boundary condition: true
constant: false
is: Q01968
name: OCRL
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_cca788ff_3e47_4e35_abee_9c7f836aab75
has only substance units: false
type: Species
is encoded by: hsa:1603
is encoded by: hsa:1650
has part: Q53G02
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
name: DAD1:DDOST:RPN1:RPN2
constant: false
has part: P04843
has part: P04844
boundary condition: true
is encoded by: hsa:6185
is encoded by: hsa:6184
has part: P39656

http://identifiers.org/biomodels.db/MODEL1310110053#_ffbbdc79_c8fa_41b2_b1ae_6a97b6df3bfa
type: Species
is: Q9UGH3
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:9962
has only substance units: false
name: SLC23A2

http://identifiers.org/biomodels.db/MODEL1310110053#_472948af_d3f2_4a05_b33a_634e3109514d
name: COX6A1
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1337
type: Species
is: P12074
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_41de0fa3_989d_4821_b0f0_ab9b1603bba1
type: Species
is: Q9H999
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:79646
boundary condition: true
name: PANK3
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_ba51037a_49c8_461e_854c_42054ebd551d
constant: false
type: Species
is: P78381
name: SLC35A2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:7355
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_e2a70bd5_1eab_49b4_a797_65f336658c50
initial amount: NaN
type: Species
is: C9JFZ1
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8867
has only substance units: false
name: SYNJ1

metaR CITt4 4
reversible: true
reactant: MODEL1310110053#
fast: false
is described by: ECO:0000006
product: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110053#
name: citrate transport via sodium symport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110053#_4e0b4fbb_16de_4097_8314_32c48dfca03b
is encoded by: hsa:4717
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: NDUFC1
has only substance units: false
is: O43677
constant: false

metaM 4mlacac c
type: Species
initial concentration: 1.0
is: HMDB02052
is: CHEBI:17105
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
name: 4-maleylacetoacetate
initial amount: NaN
has only substance units: false

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaR P450SCC1m
reversible: true
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110053#
product: MODEL1310110053#
name: cholesterol monooxygenase
type: Reaction
fast: false
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

metaR r0899
product: MODEL1310110053#
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110053#
name: Amino acid transporter ATB0+ Facilitated diffusion
reactant: MODEL1310110053#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:

metaR 7DHCHSTEROLtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110053#
name: cholesterol precursor intracellular transport
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
type: Reaction

metaR DNDPt27m
reactant: MODEL1310110053#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000269
name: dCDP transport via dTDP antiport
fast: false
kinetic law: MODEL1310110053#
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110053#_65cae2cb_4193_4b58_8299_314826d74a5f
constant: false
boundary condition: true
is: P26439
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3284
type: Species
name: HSD3B2
initial amount: NaN

metaR 4MOPte
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
product: MODEL1310110053#
type: Reaction
name: Transport of 4-methyl-2-oxopentanoate
reversible: true
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110053#_19f8d9f2_df97_453b_9f42_6f99379fecb6
constant: false
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AA854479
is: SBO:0000252
name: _AA854479_1_m

metaR r0390
product: MODEL1310110053#
reversible: true
reactant: MODEL1310110053#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
is described by: ECO:0000000
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
kinetic law: MODEL1310110053#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_0e53e2ce_f683_4550_965d_37fdd87189e4
has only substance units: false
type: Species
boundary condition: true
name: CHKA
is: SBO:0000252
constant: false
is encoded by: hsa:1119
initial concentration: NaN
is: P35790
initial amount: NaN

metaR GLXO1
is described by: ECO:0000269
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (3939.1) or (55293.1) or (3945.1 and 3939.1) or (197257.1) or (92483.1) or (3945.1) or (160287.1) or (3948.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.3.5 Confidence Level: 4 AUTHORS: PMID:12768081,PMID:9038835,PMID:9604807,PMID:9783918 NOTES:NCD
reversible: false
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.2.4
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.1.1.27
name: glyoxylate oxidase
is: SBO:0000176
reactant: MODEL1310110053#
product: MODEL1310110053#

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR r2119
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
is: SBO:0000185

metaR G14T6g
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
modifier: MODEL1310110053#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_30d398af_6e5b_4027_bd68_d8a94caf0977
boundary condition: true
is: Q96E98
is encoded by: hsa:6005
type: Species
name: RHAG
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN

metaM dtmp e
constant: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: HMDB01227
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:26999
initial amount: NaN
name: dTMP(2-)

metaM caro c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094
has only substance units: false
is: SBO:0000247
type: Species
name: beta-carotene
constant: false
is: HMDB00561
is: CHEBI:17579

http://identifiers.org/biomodels.db/MODEL1310110053#_41ae4a80_a28d_4139_bd88_a45293e35681
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is: O75912
is encoded by: hsa:9162
name: DGKI
type: Species

metaR CITt4 2
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110053#
reversible: true
fast: false
name: citrate transport via sodium symport
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
type: Reaction
product: MODEL1310110053#
reactant: MODEL1310110053#

metaR r1676
modifier: MODEL1310110053#
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110053#
product: MODEL1310110053#
reversible: false
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaR MALSO3tm
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reversible: true
is described by: ECO:0000269
is: SBO:0000185
name: Malate:sulfite antiport, mitochondrial
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
product: MODEL1310110053#

metaR S6TASE3ly
reversible: true
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110053#
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110053#
modifier: MODEL1310110053#
is described by: ECO:0000000
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176

metaM cgly c
has only substance units: false
is: CHEBI:4047
boundary condition: false
type: Species
name: L-cysteinylglycine
initial amount: NaN
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00078

metaR ARAB Lt
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110053#
type: Reaction
name: L-arabinoase extracellular transport

http://identifiers.org/biomodels.db/MODEL1310110053#_240881c0_07da_4d86_bc4d_998ec0673fe6
is: Q9Y6L6
type: Species
is encoded by: hsa:10599
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: SLCO1B1
has only substance units: false

metaM gbside hs g
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
name: globoside
type: Species
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
is: CHEBI:18259
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_f5ebec00_6855_46aa_a726_dd835c9ae273
is: SBO:0000252
is encoded by: hsa:5538
initial amount: NaN
name: PPT1
has only substance units: false
initial concentration: NaN
is: Q6FGQ4
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_d76b810f_430a_4ef6_aa09_4788228403dd
initial amount: NaN
is: E9KL44
type: Species
name: HADHA
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:3030
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_c6157565_9699_4b20_8420_61213932e5b2
initial amount: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
is: P34059
is encoded by: hsa:2588
is: SBO:0000252
name: GALNS
initial concentration: NaN

metaR FAEL205
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
kinetic law: MODEL1310110053#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
reversible: false
fast: false
name: fatty-acyl-CoA elongation (n-C20:5CoA)

metaR ACNAMtn
is: SBO:0000185
kinetic law: MODEL1310110053#
name: N-acetylneuraminate nuclear import
type: Reaction
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110053#
fast: false
reversible: false
is described by: ECO:0000000

metaR CLPNDCOAtx
fast: false
reversible: true
name: fatty acid intracellular transport
kinetic law: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110053#

metaM pap c
is: SBO:0000247
name: adenosine 3',5'-bismonophosphate(4-)
is: CHEBI:58343
has only substance units: false
is: HMDB00061
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054

W3 CDTF: Thu Aug 30 15:24:01 BST 2012

metaR r1923
name: Y+LAT2 Utilized transport
type: Reaction
fast: false
modifier: MODEL1310110053#
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: false
product: MODEL1310110053#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaM 10fthf c
name: 10-Formyltetrahydrofolate
constant: false
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454
is: C00234
has only substance units: false
is: HMDB00972
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN

metaR H2Oter
fast: false
product: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110053#
is described by: ECO:0000000
reversible: true
name: H2O endoplasmic reticulum transport

metaM dtmp m
is: CHEBI:26999
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB01227
has only substance units: false
name: dTMP
initial concentration: 1.0
constant: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: C00364
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_9929b893_98b2_4bf3_89c3_7843304adccc
name: CPT1C
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q8TCG5
is encoded by: hsa:126129
is: SBO:0000252
constant: false
has only substance units: false
type: Species

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaM CE2053 r
name: 20-oxo-leukotriene B4
is: SBO:0000247
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1/C20H30O5/c21-17-10-6-2-1-3-7-12-18(22)13-8-4-5-9-14-19(23)15-11-16-20(24)25/h3-5,7-9,13-14,17-19,22-23H,1-2,6,10-12,15-16H2,(H,24,25)/p-1/b5-4+,7-3-,13-8+,14-9-/t18-,19-/m1/s1 EHMN_ABBREVIATION: CE2053
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:57460
initial amount: NaN
constant: false
boundary condition: false
is: HMDB01509

metaR O2St
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
product: MODEL1310110053#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110053#
name: superoxide anion transport via diffusion (extracellular)
reactant: MODEL1310110053#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_3edebbbb_d8ea_4e0a_a3c6_87cf1fd35b93
constant: false
is encoded by: hsa:D87002
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
name: _D87002_1_e
boundary condition: true

metaM ump n
boundary condition: false
name: UMP(2-)
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
is: HMDB00288
has only substance units: false
is: CHEBI:57865
is: SBO:0000247
constant: false

metaM man r
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:16024
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
name: D-mannose
is: HMDB00169

metaM malthp e
is: SBO:0000247
has only substance units: false
name: maltoheptaose
type: Species
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
is: C01936
boundary condition: false
constant: false
initial concentration: 1.0

metaR NCKt
reversible: true
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
reactant: MODEL1310110053#
modifier: MODEL1310110053#
fast: false
product: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
name: Na+/Ca2+-K+ exchange

http://identifiers.org/biomodels.db/MODEL1310110053#_9db7faf0_19f4_495c_84eb_1e8ee6754823
is: P26439
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:3284
is: SBO:0000252
initial concentration: NaN
name: HSD3B2
type: Species
constant: false

metaM cgly e
boundary condition: false
name: L-cysteinylglycine
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00078
is: CHEBI:4047
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
has only substance units: false
initial concentration: 1.0

metaR BILIRUBt2
reactant: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
product: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110053#
name: bilirubin transport via bicarbonate countertransport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_e39c52cf_c2d4_4d8a_b975_f0653aaa5270
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: LDHC
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:3948
boundary condition: true

W3 CDTF: Thu Aug 30 15:24:00 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110053#_a6dc6ef9_2fea_4b10_8b51_70431649c2aa
type: Species
initial amount: NaN
constant: false
name: SLC7A9
initial concentration: NaN
is: P82251
is encoded by: hsa:11136
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_06996208_53c5_4143_9940_fa989d9d2d9d
constant: false
name: SULT1A2
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6799
has only substance units: false
initial amount: NaN
boundary condition: true

metaM nmn c
is: CHEBI:14649
is: SBO:0000247
type: Species
is: C00455
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00229
initial concentration: 1.0
constant: false
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
name: NMN

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaR CYOR u10m
modifier: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.5.1.92
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
is described by: ECO:0000134
product: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
fast: false
name: ubiquinol-6 cytochrome c reductase, Complex III

metaM glyc c
is: HMDB00131
name: Glycerol
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: C00116
boundary condition: false
is: SBO:0000247
is: CHEBI:17754
initial amount: NaN
has only substance units: false

metaM hco3 m
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
name: Bicarbonate
is: HMDB00595
boundary condition: false
initial amount: NaN
is: C00288
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:17544
type: Species

metaR RE2660C
type: Reaction
reactant: MODEL1310110053#
name: RE2660
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000176

metaR r0276
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.1.1.21
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
product: MODEL1310110053#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2
type: Reaction
modifier: MODEL1310110053#

W3 CDTF: Thu Aug 30 15:24:00 BST 2012

metaR r1925
name: Y+LAT2 Utilized transport
fast: false
reactant: MODEL1310110053#
modifier: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_f77923ed_4053_489c_a50b_10f1f298be76
initial concentration: NaN
name: COX8C
has only substance units: false
type: Species
boundary condition: true
constant: false
is: Q7Z4L0
is encoded by: hsa:341947
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_e7647df1_d86b_451f_8955_c6ced432a867
is: A8K596
type: Species
is encoded by: hsa:1757
initial amount: NaN
boundary condition: true
name: SARDH
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaR CAATPS
is described by: ECO:0000269
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
product: MODEL1310110053#
name: Ca ATPase
is version of: http://identifiers.org/ec-code/3.6.3.8
fast: false
reversible: false

metaM ala L m
is: HMDB00161
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
name: L-alanine
is: CHEBI:16977
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048

metaM HC00695 m
name: S-Succinyldihydrolipoamide
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
has only substance units: false
initial amount: NaN
is: CHEBI:17432
type: Species
constant: false
is: SBO:0000247

metaR RE1807C
name: RE1807
fast: false
product: MODEL1310110053#
reversible: true
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#

metaR PROt4
reversible: false
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: (55089.1) or (81539.1) or (54407.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
modifier: MODEL1310110053#
type: Reaction
name: Na+/Proline-L symporter
is described by: ECO:0000269
fast: false
reactant: MODEL1310110053#

metaM prostgh2 r
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57405
is: HMDB01381
initial concentration: 1.0
name: prostaglandin H2(1-)
constant: false

metaM rbt e
has only substance units: false
is: SBO:0000247
is: HMDB00508
name: D-ribitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:15963

http://identifiers.org/biomodels.db/MODEL1310110053#_9703caaf_fff0_449a_80c0_b57f45192a32
is encoded by: hsa:122622
initial concentration: NaN
constant: false
is: Q8N142
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: ADSSL1

http://identifiers.org/biomodels.db/MODEL1310110053#_12d52f7c_115e_4939_a79a_94cd38b55b51
type: Species
boundary condition: true
name: PSAT1
is: SBO:0000252
is encoded by: hsa:29968
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR 5ADTSTSTERONEtr
product: MODEL1310110053#
fast: false
type: Reaction
kinetic law: MODEL1310110053#
reversible: true
name: 5 alpha dihydrotesterone intracellular transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
reactant: MODEL1310110053#

metaR 3HKYNAKGAT
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.6.1.7
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
fast: false
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
is: SBO:0000176
is described by: ECO:0000304
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.6.1.64
reactant: MODEL1310110053#
type: Reaction
reversible: false

metaR r0321
product: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.5.2
type: Reaction
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
reversible: false
fast: false
reactant: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#

metaR r2079
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110053#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#
is described by: ECO:0000000

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

metaM hom L e
is: CHEBI:15699
initial amount: NaN
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
name: L-homoserine
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00719
is: SBO:0000247
has only substance units: false

metaR IMPC
kinetic law: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.3
fast: false
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
reversible: true
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110053#
name: IMP cyclohydrolase
reactant: MODEL1310110053#

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaR LEUTA
is described by: ECO:0000269
kinetic law: MODEL1310110053#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
reversible: true
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110053#
modifier: MODEL1310110053#
name: leucine transaminase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_6e53a91f_b093_4b26_a848_af497b377671
type: Species
is: E7EQF2
name: CROT
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:54677
initial concentration: NaN
initial amount: NaN
constant: false

metaR EX txa2 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thromboxane A2 exchange
type: Reaction

metaR XYLtly
name: Xylose efflux from lysosome
type: Reaction
reactant: MODEL1310110053#
is: SBO:0000185
product: MODEL1310110053#
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD

metaR HDCAtr
is: SBO:0000185
name: fatty acid transport via diffusion
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110053#
type: Reaction
reversible: true
fast: false

metaR NAIt
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110053#
modifier: MODEL1310110053#
reversible: true
fast: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000269
name: Na+ / iodide cotransport
type: Reaction

metaM glyc e
is: HMDB00131
initial amount: NaN
name: Glycerol
has only substance units: false
is: SBO:0000247
is: C00116
is: CHEBI:17754
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116

http://identifiers.org/biomodels.db/MODEL1310110053#_d399bca1_f04e_4b81_80ea_b35ae1daa8c4
is: Q9BV10
initial amount: NaN
name: ALG12
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:79087
boundary condition: true

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaM ump c
initial concentration: 1.0
type: Species
is: CHEBI:57865
boundary condition: false
constant: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
is: C00105
name: UMP
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR r2114
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
product: MODEL1310110053#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110053#
reactant: MODEL1310110053#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110053#
type: Reaction

metaR FE2t
kinetic law: MODEL1310110053#
fast: false
name: iron (II) transport
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12440707 NOTES:
product: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110053#

metaR r1671
reversible: true
fast: false
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Y+LAT2 Utilized transport
product: MODEL1310110053#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_cf1cb6f3_d6d3_4ac5_9b89_a25db4478c82
name: SKIV2L2
initial amount: NaN
boundary condition: true
is: Q3MHC9
has only substance units: false
constant: false
is encoded by: hsa:23517
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_96515d32_2c42_4f69_b80b_f7a24654f7f1
is: SBO:0000252
type: Species
boundary condition: true
is: Q15392
initial concentration: NaN
constant: false
name: DHCR24
initial amount: NaN
is encoded by: hsa:1718
has only substance units: false

metaM dgmp e
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
has only substance units: false
boundary condition: false
name: dGMP(2-)
is: HMDB01044
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:57673
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_3754ee01_4a4d_401e_8207_fd1c5213f6e0
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3423
boundary condition: true
has only substance units: false
name: IDS
constant: false
is: P22304
type: Species

metaR RETI2
fast: false
reversible: true
product: MODEL1310110053#
name: retinol isomerase (9-cis)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
type: Reaction
reactant: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_0fcf7b06_7ae1_409f_a316_edc84fc90a11
initial concentration: NaN
type: Species
is encoded by: hsa:501
constant: false
name: ALDH7A1
initial amount: NaN
boundary condition: true
is: E7EPT3
has only substance units: false
is: SBO:0000252

metaM betald m
boundary condition: false
is: CHEBI:15710
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB01252
initial concentration: 1.0
name: betaine aldehyde
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_79bb8d55_b363_411f_87f3_05de651c13f7
boundary condition: true
type: Species
name: NDUFS5
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is: Q6IBA0
is encoded by: hsa:4725
initial concentration: NaN

metaR r2113
is: SBO:0000185
type: Reaction
product: MODEL1310110053#
reactant: MODEL1310110053#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110053#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR S6T10g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000176
kinetic law: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaM coa e
has only substance units: false
name: Coenzyme A
is: HMDB01423
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
boundary condition: false
is: SBO:0000247
is: CHEBI:57287
is: C00010
initial amount: NaN

metaR r1590
product: MODEL1310110053#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110053#
is: SBO:0000185
fast: false
type: Reaction

metaM msa m
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
name: 3-oxopropanoate
is: HMDB11111
is: CHEBI:33190
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false

metaR RE0453M
type: Reaction
kinetic law: MODEL1310110053#
product: MODEL1310110053#
modifier: MODEL1310110053#
reversible: true
name: RE0453
fast: false
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6

http://identifiers.org/biomodels.db/MODEL1310110053#_34c514ae_1b92_4bac_856f_1b7a7263e043
initial concentration: NaN
is encoded by: hsa:5315
boundary condition: true
is: SBO:0000252
has only substance units: false
is: P14618
initial amount: NaN
type: Species
name: PKM2
constant: false

metaR r1670
is: SBO:0000185
modifier: MODEL1310110053#
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110053#
product: MODEL1310110053#

metaR r2112
reversible: true
product: MODEL1310110053#
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_b07ad833_d856_4d1e_9934_094e2a30fa4f
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:9057
type: Species
has only substance units: false
name: SLC7A6
is: Q92536
initial amount: NaN
initial concentration: NaN

metaM 10fthf e
type: Species
is: HMDB00972
initial amount: NaN
name: 10-formyltetrahydrofolate(2-)
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
has only substance units: false
is: CHEBI:57454

http://identifiers.org/biomodels.db/MODEL1310110053#_256c2038_679c_49e2_bb2f_e85561e9cfcc
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:122481
name: AK7
constant: false
type: Species
is: Q96M32

metaR RBFK
kinetic law: MODEL1310110053#
reversible: false
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110053#
type: Reaction
name: riboflavin kinase
is version of: http://identifiers.org/ec-code/2.7.1.26
fast: false
modifier: MODEL1310110053#

metaR TCYNTtm
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110053#
product: MODEL1310110053#
reversible: false
fast: false
type: Reaction
name: Thiocyanate transport via diffusion (mitochondrial)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
kinetic law: MODEL1310110053#

metaR P45027A1m
reversible: false
modifier: MODEL1310110053#
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110053#
fast: false
name: Cytochrome P450 27
kinetic law: MODEL1310110053#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110053#_16832575_b195_48b7_b585_4894498e964c
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is: Q8IX04
has only substance units: false
name: UEVLD
initial concentration: NaN
is encoded by: hsa:55293
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_98e056d7_cf43_42c2_b57f_0f9bc566a530
constant: false
has only substance units: false
initial concentration: NaN
has part: P08195
is encoded by: hsa:6520
has part: Q9NS82
type: Species
is encoded by: hsa:56301
boundary condition: true
initial amount: NaN
is: SBO:0000297
name: SLC7A10:SLC3A2

metaM mal L m
initial amount: NaN
is: HMDB00156
is: SBO:0000247
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
boundary condition: false
initial concentration: 1.0
is: CHEBI:15589
name: (S)-malate(2-)
constant: false
type: Species
has only substance units: false

metaM hom L c
type: Species
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial amount: NaN
boundary condition: false
is: HMDB00719
constant: false
has only substance units: false
is: CHEBI:15699
initial concentration: 1.0
is: SBO:0000247
name: L-homoserine

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaR HACD1m
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110053#
fast: false
product: MODEL1310110053#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
is described by: ECO:0000134

metaR r2111
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110053#
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
is described by: ECO:0000000
product: MODEL1310110053#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_15285203_eba3_4a68_8400_8b1a339dbd14
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
name: SLC12A6
has only substance units: false
boundary condition: true
is encoded by: hsa:9990
is: Q9UHW9

http://identifiers.org/biomodels.db/MODEL1310110053#_99266208_29d6_4d09_999a_0d702d5ca7ef
boundary condition: true
is encoded by: hsa:1806
initial amount: NaN
constant: false
is: SBO:0000252
is: Q12882
has only substance units: false
name: DPYD
type: Species
initial concentration: NaN

metaM dgmp c
constant: false
has only substance units: false
name: dGMP
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01044
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: SBO:0000247
type: Species
is: C00362
is: CHEBI:57673

metaR PROSTGE2t2
kinetic law: MODEL1310110053#
name: prostaglandin uniport
modifier: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
type: Reaction
reactant: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000269
reversible: true
fast: false

W3 CDTF: Thu Aug 30 15:24:01 BST 2012

metaM 4mop m
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
type: Species
is: CHEBI:17865
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
name: 4-methyl-2-oxopentanoate
is: HMDB00695

metaR G6PDH2rer
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
is: SBO:0000176
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
kinetic law: MODEL1310110053#
is described by: ECO:0000269
product: MODEL1310110053#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.47
modifier: MODEL1310110053#
reversible: true

metaM sphmyln hs c
type: Species
initial amount: NaN
constant: false
name: sphmyln_hs[c]
initial concentration: 1.0
is: HMDB01342
has only substance units: false
is: SBO:0000247
notes: FORMULA: CHARGE: 0
boundary condition: false

metaM pd3 c
constant: false
initial concentration: 1.0
is: HMDB06500
has only substance units: false
type: Species
name: Previtamin D3
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
boundary condition: false

metaM uacgam g
is: CHEBI:57705
type: Species
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: HMDB00290
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043

metaM coa c
is: C00010
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
type: Species
is: HMDB01423
constant: false
boundary condition: false
is: CHEBI:3312
has only substance units: false
name: Coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110053#_a320a2a3_7a25_4e61_bb8f_85e3f3bc4d80
initial amount: NaN
is: Q9NVE7
name: PANK4
type: Species
is: SBO:0000252
is encoded by: hsa:55229
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

metaM acnam n
boundary condition: false
is: HMDB00230
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: CHEBI:35418
has only substance units: false
name: N-acetylneuraminate

metaM val L e
is: CHEBI:16414
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
name: L-valine
boundary condition: false
is: HMDB00883

metaM 2hb c
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
type: Species
is: HMDB00008
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
name: 2-Hydroxybutyrate
is: CHEBI:1148
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_0cfcff04_31e0_49bc_83d5_bf7b6b978b8c
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is: E5KSL6
is encoded by: hsa:1716
name: DGUOK

metaR CYTK5n
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
is: SBO:0000176
reversible: true
modifier: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
name: cytidylate kinase (CMP),nuclear
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
product: MODEL1310110053#

metaM ump g
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
initial concentration: 1.0
is: CHEBI:57865
initial amount: NaN
has only substance units: false
constant: false
name: UMP(2-)

metaR r2118
reversible: true
fast: false
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110053#
is: SBO:0000185

metaR KSII CORE2t
product: MODEL1310110053#
name: keratan sulfate II (core2) transport, golgi to extracellular
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_933320c4_f428_44d3_be92_8b1163990e4a
initial concentration: NaN
constant: false
is: Q9BZV2
type: Species
is: SBO:0000252
has only substance units: false
name: SLC19A3
boundary condition: true
initial amount: NaN
is encoded by: hsa:80704

metaR TRDR
type: Reaction
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
reactant: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
name: thioredoxin reductase (NADPH)
kinetic law: MODEL1310110053#
is described by: ECO:0000269
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.8.1.9
is: SBO:0000176
reversible: false

metaM glutcoa m
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
name: glutaryl-CoA(5-)
has only substance units: false
is: CHEBI:57378
boundary condition: false
is: HMDB01339
initial amount: NaN
initial concentration: 1.0

metaR AG13T3g
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110053#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110053#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
modifier: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
fast: false

metaM ahcys m
name: S-Adenosyl-L-homocysteine
is: SBO:0000247
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: CHEBI:16680
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: C00021
is: HMDB00939
constant: false

metaM caro e
name: beta-carotene
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17579
has only substance units: false
is: HMDB00561
type: Species
constant: false
boundary condition: false
is: SBO:0000247

metaR r2539
product: MODEL1310110053#
name: Postulated transport reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
type: Reaction

metaR CITRtm
product: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
fast: false
name: citrulline mitochondrial transport via proton antiport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_4a2d2ed4_360e_4a8f_b117_8659115356e8
initial concentration: NaN
has only substance units: false
type: Species
constant: false
name: PANK1
is encoded by: hsa:53354
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR RE2660N
is version of: http://identifiers.org/ec-code/4.2.1.96
is described by: ECO:0000000
name: RE2660
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
reversible: true
reactant: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#

metaM dtmp c
initial concentration: 1.0
is: CHEBI:26999
is: C00364
type: Species
has only substance units: false
name: dTMP
is: HMDB01227
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364

metaR r2117
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110053#
product: MODEL1310110053#
reversible: true
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction

metaR GLYBtm
is: SBO:0000185
kinetic law: MODEL1310110053#
product: MODEL1310110053#
name: Glycine betaine transport via diffusion (mitochondria to cytosol)
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8443213 NOTES:MM
reactant: MODEL1310110053#
is described by: ECO:0000000
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_27bf48e1_3281_4a40_a930_a8d2b3dca4a2
is: A6NN98
name: MTMR2
type: Species
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8898
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110053#_905f8be9_35ad_4b95_ba7d_78d097e4cd4d
initial amount: NaN
is: Q4KWH8
boundary condition: true
name: PLCH1
is: SBO:0000252
is encoded by: hsa:23007
has only substance units: false
type: Species
initial concentration: NaN
constant: false

metaR RE0958E
kinetic law: MODEL1310110053#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110053#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.1
is: SBO:0000176
product: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
name: RE0958
is version of: http://identifiers.org/ec-code/3.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110053#_8c1dd263_5bd4_4307_bb4f_bdc97ebb1bdd
name: SCD5
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q86SK9
constant: false
initial amount: NaN
is encoded by: hsa:79966
type: Species

metaR SRTNt6 2 r
product: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
is: SBO:0000185
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false

metaR 3MOBte
fast: false
type: Reaction
kinetic law: MODEL1310110053#
reversible: true
is: SBO:0000185
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110053#
name: Transport of 3-methyl-2-oxobutanoate

metaR ACCOAC
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaR FALDH
reversible: true
product: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000269
reactant: MODEL1310110053#
fast: false
name: formaldehyde dehydrogenase
modifier: MODEL1310110053#
type: Reaction

metaR r0475
fast: false
type: Reaction
kinetic law: MODEL1310110053#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110053#
is: SBO:0000176
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

metaR r2070
reactant: MODEL1310110053#
fast: false
reversible: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110053#
kinetic law: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110053#

metaR PHETHPTOX2
modifier: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.14.16.1
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
product: MODEL1310110053#
is: SBO:0000176
kinetic law: MODEL1310110053#

metaM val L c
name: L-valine
is: CHEBI:16414
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00883
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_6e245e65_a1dd_49de_92d5_6d8989db5721
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:6482
name: ST3GAL1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_8411934e_7b78_4de4_ad14_dc733a3e1cab
type: Species
has only substance units: false
constant: false
name: _AI348006_1_c
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AI348006

metaM m1mpdol U c
boundary condition: false
is: CHEBI:28067
has only substance units: false
initial concentration: 1.0
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
type: Species
notes: FORMULA: C1305H2140N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
constant: false
is: SBO:0000247

metaM 2hb e
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00008
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
is: CHEBI:1148
name: 2-Hydroxybutyrate
initial amount: NaN
boundary condition: false

metaR SMPD4
type: Reaction
reversible: false
is: SBO:0000176
name: sphingomyelinase
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
kinetic law: MODEL1310110053#
product: MODEL1310110053#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110053#_31972446_7a1a_481e_b15b_1b42b394709c
is encoded by: hsa:AI915649
name: _AI915649_1_c
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_a4154792_55de_4df3_9102_832f0fb7c21d
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: B1AM93
is: SBO:0000252
name: NDUFA8
initial concentration: NaN
is encoded by: hsa:4702
boundary condition: true

metaR NADPtru
reactant: MODEL1310110053#
name: NADP transporter, endoplasmic reticulum
reversible: false
fast: false
is: SBO:0000185
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
product: MODEL1310110053#
type: Reaction

metaR r2116
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110053#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110053#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#

metaM ksii core2 e
is: HMDB00211
initial amount: NaN
constant: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: CHEBI:17268
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: keratan sulfate II (core 2-linked)
is: SBO:0000247

metaM gthrd m
initial concentration: 1.0
is: CHEBI:57925
initial amount: NaN
is: HMDB00125
boundary condition: false
constant: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
has only substance units: false
name: glutathionate(1-)
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110053#_eec51b4e_e339_4a72_9297_8b317402b79d
name: CPT1B
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is: Q53FV7
has only substance units: false
is encoded by: hsa:1375
boundary condition: true
type: Species

metaR EX fmn LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for FMN
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_94965468_f029_43bc_ad0a_f69f38cae49e
is: P21439
boundary condition: true
name: ABCB4
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:5244

http://identifiers.org/biomodels.db/MODEL1310110053#_25699667_d27b_41b9_af3c_75e5ae0cecb6
initial concentration: NaN
name: ACSS3
is: SBO:0000252
is encoded by: hsa:79611
initial amount: NaN
type: Species
is: Q9H6R3
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_d33d1945_2743_45b2_ba64_663f80083d55
name: GALNT4
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8693
type: Species
initial concentration: NaN
is: Q8N4A0
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_b23d6fc1_571c_4efc_bfee_b12fe7daedf5
boundary condition: true
type: Species
initial amount: NaN
name: MANBA
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:4126
initial concentration: NaN
is: O00462

metaR r0688
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110053#
product: MODEL1310110053#
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110053#
reactant: MODEL1310110053#

metaM hs deg1 l
initial concentration: 1.0
initial amount: NaN
name: heparan sulfate, degradation product 1
type: Species
is: CHEBI:17180
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
is: HMDB01352
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_c17b092f_3a43_4a31_b479_74c6f9a4af0d
is: SBO:0000252
has only substance units: false
name: RDH12
is: Q96NR8
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:145226
type: Species

metaM 3oddcoa m
is: SBO:0000247
is: CHEBI:27868
name: 3-Oxododecanoyl-CoA
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
constant: false
is: HMDB03937
has only substance units: false

metaR It
is: SBO:0000185
reversible: true
name: Iodide uniport
is described by: ECO:0000269
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
type: Reaction
fast: false
product: MODEL1310110053#
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD

metaR CDPDAGtm
reactant: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
reversible: true
kinetic law: MODEL1310110053#
fast: false
name: intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
is: SBO:0000185
is described by: ECO:0000000

metaM glyc m
constant: false
is: HMDB00131
has only substance units: false
name: Glycerol
is: SBO:0000247
is: C00116
type: Species
initial amount: NaN
is: CHEBI:17754
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial concentration: 1.0
boundary condition: false

metaM frdp c
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: C00448
name: Farnesyl diphosphate
initial amount: NaN
is: HMDB00961
is: CHEBI:175763
constant: false
is: SBO:0000247

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_58e3023f_b8cc_4820_8bb8_7ac637e04977
name: UGP2
has only substance units: false
is: Q16851
boundary condition: true
is encoded by: hsa:7360
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN

metaM CE2056 r
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1/C20H32O6/c21-17(11-6-2-1-3-9-15-19(23)24)12-7-4-5-8-13-18(22)14-10-16-20(25)26/h2,4-8,12-13,17-19,21-24H,1,3,9-11,14-16H2,(H,25,26)/p-1/b5-4+,6-2-,12-7+,13-8-/t17-,18-/m0/s1 EHMN_ABBREVIATION: CE2056
initial amount: NaN
has only substance units: false
name: 20-dihydroxyleukotriene B4
is: HMDB01509
boundary condition: false
constant: false
is: CHEBI:57460

metaR r2115
modifier: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
reactant: MODEL1310110053#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110053#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110053#_b5d440ae_86bb_4f10_8225_52e6f47fee1d
is encoded by: hsa:AI291895
name: _AI291895_1_c
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true

metaM 4abutn e
has only substance units: false
is: HMDB01080
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:58264
initial concentration: 1.0
is: SBO:0000247
name: 4-ammoniobutanal
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_d2dc20c0_06b8_42c1_af0f_a84bf40cfd3a
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
constant: false
is: P61457
is encoded by: hsa:5092
initial amount: NaN
initial concentration: NaN
name: PCBD1

metaM tststerone e
is: SBO:0000247
type: Species
has only substance units: false
name: testosterone
initial amount: NaN
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: CHEBI:17347
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00234

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaM 4mop c
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
name: 4-methyl-2-oxopentanoate
boundary condition: false
is: CHEBI:17865
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00695
initial amount: NaN
initial concentration: 1.0
constant: false

metaR OROTGLUt
product: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
reactant: MODEL1310110053#
name: OROTGLUt
reversible: true
is: SBO:0000185

metaR r1598
reactant: MODEL1310110053#
reversible: true
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000000

metaM k e
name: potassium
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00586
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
has only substance units: false
is: SBO:0000247
is: C00238
constant: false
is: CHEBI:29103
type: Species

metaR CITtam
reversible: true
is described by: ECO:0000269
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
name: citrate transport, mitochondrial
is: SBO:0000185
modifier: MODEL1310110053#
type: Reaction
fast: false

metaR r2081
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
product: MODEL1310110053#

metaM 10fthf7glu e
is: CHEBI:57454
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: 10-formyltetrahydrofolate-[Glu](7)
is: HMDB00972
initial amount: NaN
type: Species
notes: FORMULA: C50H57N13O25 CHARGE: -8
constant: false
has only substance units: false

metaR TSTSTERONEt
reversible: true
reactant: MODEL1310110053#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
fast: false
product: MODEL1310110053#
name: Testosterone transport
type: Reaction
kinetic law: MODEL1310110053#
is: SBO:0000185

metaR RE1448N
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
name: RE1448
kinetic law: MODEL1310110053#
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110053#
is: SBO:0000176
reactant: MODEL1310110053#

metaR r0801
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110053#
modifier: MODEL1310110053#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:

metaR r2324
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reactant: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110053#_b1842dd2_0c1b_49ce_82eb_f90c53a1fde4
boundary condition: true
initial amount: NaN
is encoded by: hsa:2222
is: SBO:0000252
constant: false
name: FDFT1
type: Species
is: P37268
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_265a0381_93d5_4d2d_9de6_b8d729f9e506
constant: false
name: SUCLA2
is encoded by: hsa:8803
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is: E5KS60
initial concentration: NaN
initial amount: NaN

metaM mal L c
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
initial amount: NaN
is: CHEBI:15589
is: HMDB00156
initial concentration: 1.0
constant: false
boundary condition: false
name: (S)-malate(2-)

metaM hs deg16 l
constant: false
type: Species
is: HMDB02704
initial amount: NaN
name: heparan sulfate, degradation product 16
has only substance units: false
is: CHEBI:21338
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C49H72N2O54S4 CHARGE: -6

metaR METtec
fast: false
name: L-methionine transport via diffusion (extracellular to cytosol)
type: Reaction
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
product: MODEL1310110053#
is: SBO:0000185
modifier: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110053#

metaR FATP3t
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110053#
name: fatty acid electroneutral transport
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
modifier: MODEL1310110053#
is described by: ECO:0000269
reactant: MODEL1310110053#
product: MODEL1310110053#
reversible: true
fast: false

metaM sarcs m
is: CHEBI:15611
constant: false
name: Sarcosine
initial concentration: 1.0
has only substance units: false
is: C00213
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00271
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213

metaM pmtcoa c
name: Palmitoyl-CoA (n-C16:0CoA)
initial amount: NaN
is: SBO:0000247
is: C00154
is: CHEBI:3454
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
constant: false
is: HMDB01338
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_4c602e04_c1e2_420b_aedd_17eea04ae61a
boundary condition: true
is encoded by: hsa:1431
initial amount: NaN
is: SBO:0000252
constant: false
name: CS
initial concentration: NaN
has only substance units: false
type: Species

metaR GGT6
is described by: ECO:0000000
product: MODEL1310110053#
reversible: true
reactant: MODEL1310110053#
is: SBO:0000176
type: Reaction
fast: false
name: Gamma-glutamyltransferase
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
kinetic law: MODEL1310110053#

metaM nm4masn g
type: Species
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C54H90N3O40X CHARGE: 0
has only substance units: false
is: C05882
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_fe1be9a5_ae5f_44a7_ac99_6d4934d81baa
type: Species
boundary condition: true
is: SBO:0000252
is: P19367
initial concentration: NaN
is encoded by: hsa:3098
has only substance units: false
name: HK1
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_43280a75_2208_4085_8e77_5a550bf6cf89
is: SBO:0000252
name: TK2
is: O00142
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:7084
boundary condition: true
has only substance units: false

metaR r1597
kinetic law: MODEL1310110053#
product: MODEL1310110053#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110053#_dd5f6220_39ab_47bd_bf7c_f9f75c890184
is: Q92523
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:1375
name: CPT1B
boundary condition: true
initial amount: NaN
type: Species

metaR r0604
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
type: Reaction
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
reversible: false
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
product: MODEL1310110053#
is described by: ECO:0000000
modifier: MODEL1310110053#

metaM ksi pre32 g
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 32
boundary condition: false
has only substance units: false
is: CHEBI:28067
initial concentration: 1.0
notes: FORMULA: C227H362N16O192S10X CHARGE: -11

metaR r2080
reversible: true
product: MODEL1310110053#
fast: false
type: Reaction
reactant: MODEL1310110053#
modifier: MODEL1310110053#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_3013b5b9_d1cb_495e_828c_4ffefd82f79a
is: SBO:0000252
initial concentration: NaN
is: Q96PE7
constant: false
boundary condition: true
name: MCEE
initial amount: NaN
is encoded by: hsa:84693
has only substance units: false
type: Species

metaR RBTt
fast: false
type: Reaction
name: ribitol transport via passive diffusion
product: MODEL1310110053#
reversible: false
is: SBO:0000185
reactant: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaM fol c
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00121
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial concentration: 1.0
type: Species
constant: false
name: Folate
boundary condition: false

metaM HC01231 c
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: N-[(R)-pantothenoyl]-L-cysteinate
is: CHEBI:58480

metaR r2323
is: SBO:0000185
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110053#
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_08cdae51_1839_4539_9026_3ec4a9c3eaab
constant: false
initial amount: NaN
name: ST3GAL3
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6487
is: Q5T4Y1
boundary condition: true
is: SBO:0000252

metaM hs deg13 l
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:17180
has only substance units: false
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
initial amount: NaN
boundary condition: false
name: heparan sulfate, degradation product 13
is: HMDB01352
constant: false

metaM fol e
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C19H18N7O6 CHARGE: -1
constant: false
is: HMDB00121
type: Species
name: Folate

metaR r0160
product: MODEL1310110053#
reversible: false
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.3.2
is described by: ECO:0000000
fast: false
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51

metaR GTMLTe
modifier: MODEL1310110053#
is: SBO:0000185
fast: false
reversible: false
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES:NCD SAB e see Disussion section of PMID 15469854
type: Reaction
product: MODEL1310110053#
is described by: ECO:0000269
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.3.2.2
name: g-glutamyltransferase (e)

http://identifiers.org/biomodels.db/MODEL1310110053#_fde48f90_467b_45d1_a106_5353de818554
is: Q14435
has only substance units: false
type: Species
name: GALNT3
is encoded by: hsa:2591
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252

metaM lys L m
is: SBO:0000247
is: CHEBI:32551
initial amount: NaN
is: HMDB00182
has only substance units: false
name: L-lysinium(1+)
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047

metaM 4mop e
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
is: SBO:0000247
is: CHEBI:17865
boundary condition: false
type: Species
name: 4-methyl-2-oxopentanoate
is: HMDB00695
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0

metaM k c
initial concentration: 1.0
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: C00238
constant: false
is: SBO:0000247
is: CHEBI:29103
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
name: potassium
is: HMDB00586

metaR r1596
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110053#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110053#
fast: false
product: MODEL1310110053#

metaM 3otdcoa m
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
is: CHEBI:28726
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
boundary condition: false
name: 3-Oxotetradecanoyl-CoA
is: SBO:0000247
is: HMDB03935
has only substance units: false

metaR CMPSAS
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.43
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
is described by: ECO:0000304
fast: false
is: SBO:0000176
name: CMP sialic acid synthase
product: MODEL1310110053#
type: Reaction

metaM pglyc hs e
is: CHEBI:60523
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
name: phosphatidylglycerol(1-)
initial amount: NaN

metaR r2322
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110053#
product: MODEL1310110053#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_e5cbe93d_cf99_4d6e_a0a6_ea00f2c573aa
name: _AI769281_1_e
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:AI769281
initial concentration: NaN

metaR LEUGLYHYc
is described by: ECO:0000134
is: SBO:0000176
product: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
reactant: MODEL1310110053#
name: hydrolysis of leucylglycine
type: Reaction

metaM thbpt4acam n
has only substance units: false
type: Species
is: HMDB02281
initial amount: NaN
constant: false
name: 4a-hydroxytetrahydrobiopterin
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:15374

http://identifiers.org/biomodels.db/MODEL1310110053#_ba6d5841_4cb0_4bd3_837f_f2ce90149d88
initial amount: NaN
is encoded by: hsa:6241
is: P31350
name: RRM2
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
type: Species

metaM xol7aone m
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: 7alpha-hydroxycholest-4-en-3-one
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: HMDB01993
has only substance units: false
constant: false
is: CHEBI:17899

metaR GLYCTDle
type: Reaction
kinetic law: MODEL1310110053#
is described by: ECO:0000134
reactant: MODEL1310110053#
name: difussion of glycerol accross the brush border membrane
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
fast: false
product: MODEL1310110053#
is: SBO:0000185

metaM man c
name: D-Mannose
is: C00159
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:16024
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: HMDB00169

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_9334e26e_e11e_4165_904d_b5297b4c3e8c
constant: false
type: Species
is: SBO:0000252
is: B2RAT6
is encoded by: hsa:2592
name: GALT
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false

metaR 5ADTSTSTERONEte
reversible: true
fast: false
reactant: MODEL1310110053#
name: 5 alpha dihydrotesterone transport
kinetic law: MODEL1310110053#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaM g1m8mpdol U r
constant: false
type: Species
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:59093
notes: FORMULA: C1785H2940N20O670P20 CHARGE: -20

metaR r1010
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110053#
is: SBO:0000185
name: Postulated transport reaction
reversible: true
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false

metaM mal L e
is: SBO:0000247
type: Species
name: (S)-malate(2-)
has only substance units: false
initial amount: NaN
is: HMDB00156
is: CHEBI:15589
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1

metaR r2321
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR ETHAK
is version of: http://identifiers.org/ec-code/2.7.1.32
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1119.2) or (55500.1) or (1119.1) or (55224.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.82 Confidence Level: 4 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110053#
fast: false
type: Reaction
product: MODEL1310110053#
modifier: MODEL1310110053#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.82
reactant: MODEL1310110053#
name: Ethanolamine kinase

http://identifiers.org/biomodels.db/MODEL1310110053#_fbacc978_0c09_4a2b_8d5b_fc97cd6f2a2f
boundary condition: true
initial amount: NaN
type: Species
is: Q9UBX3
constant: false
is encoded by: hsa:1468
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: SLC25A10

http://identifiers.org/biomodels.db/MODEL1310110053#_74237dc5_274a_4bc7_abf2_171e6e30ff59
name: UROD
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:7389
has only substance units: false
is: SBO:0000252
is: P06132
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_1a3dc2dc_0c31_4e9c_8e10_ea84863c3f35
initial amount: NaN
boundary condition: true
is encoded by: hsa:54344
is: SBO:0000252
name: DPM3
initial concentration: NaN
constant: false
type: Species
is: Q9P2X0
has only substance units: false

metaR CHAT
fast: false
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.3.1.6
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000269
type: Reaction
name: Choline O-acetyltransferase
reversible: true
is: SBO:0000176
reactant: MODEL1310110053#

metaR r1595
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110053#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110053#

metaR NDPK3m
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
fast: false
reactant: MODEL1310110053#
is described by: ECO:0000254
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
product: MODEL1310110053#

metaM thym e
boundary condition: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: HMDB00262
is: SBO:0000247
type: Species
name: thymine
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17821

metaR FMNALKPle
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000176
name: FMNALKPle
reactant: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000134

metaR MALSO4tm
reversible: true
fast: false
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Malate:sulfate antiport, mitochondrial
modifier: MODEL1310110053#
reactant: MODEL1310110053#
is described by: ECO:0000269
product: MODEL1310110053#
is: SBO:0000185
type: Reaction

metaR GTHDH
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
product: MODEL1310110053#
name: Glutathione dehydrogenase (dehydroascorbate reductase)

metaM CE2838 e
is: SBO:0000247
name: maltononaose
initial concentration: 1.0
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
is: C01936
is: http://identifiers.org/pubchem.compound/5041
type: Species
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false

metaM CE4872 m
constant: false
is: HMDB00127
boundary condition: false
is: CHEBI:15748
is: SBO:0000247
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
has only substance units: false

metaR CYTK4n
modifier: MODEL1310110053#
name: cytidylate kinase (dCMP,GTP),nuclear
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110053#
reversible: true
kinetic law: MODEL1310110053#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM HC01397 m
name: (S)-3-Hydroxyhexadecanoyl-CoA
has only substance units: false
constant: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
is: CHEBI:27402
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_c6880396_4d56_45f1_9c7c_5882afeb9d7d
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:1103
boundary condition: true
name: CHAT
initial amount: NaN
has only substance units: false
is: Q6LEN5

metaR NRPPHRSFt
type: Reaction
name: norepinephrine sulfate transport (diffusion)
kinetic law: MODEL1310110053#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB

metaR r1594
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110053#_38858cf6_6a80_4924_b63e_3d5e0a128d80
initial concentration: NaN
name: HSD3B7
type: Species
is: Q9H2F3
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:80270
boundary condition: true
constant: false
has only substance units: false

metaR RPEc
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
kinetic law: MODEL1310110053#
fast: false
name: ribulose 5-phosphate 3-epimerase
is described by: ECO:0000134
reactant: MODEL1310110053#

metaR r2320
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110053#
reactant: MODEL1310110053#
reversible: true
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_97fa39d1_1dcb_4f74_b689_7dcf537ce802
boundary condition: true
initial amount: NaN
name: GALNT11
type: Species
is: SBO:0000252
is: B3KWF4
constant: false
initial concentration: NaN
is encoded by: hsa:63917
has only substance units: false

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR RE3218C
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110053#
reversible: true
name: RE3218
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
is version of: http://identifiers.org/ec-code/3.1.6.2
modifier: MODEL1310110053#
product: MODEL1310110053#
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_5590b34a_afe0_4f7f_b716_2f98f4297c6b
initial amount: NaN
is: B7Z6Q4
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3612
type: Species
constant: false
name: IMPA1

http://identifiers.org/biomodels.db/MODEL1310110053#_793937a2_1315_46e0_bd3b_d13129e7005e
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P45954
name: ACADSB
is encoded by: hsa:36
is: SBO:0000252
type: Species

metaM g3m8mpdol U r
is: C05873
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1905H3140N20O770P20 CHARGE: -20
type: Species
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_d0e655ab_7018_4568_a7fa_e5c6bf68f844
boundary condition: true
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI935189
name: _AI935189_1_m

metaM pglyc hs c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: pglyc_hs[c]
is: CHEBI:21338
type: Species
constant: false
notes: FORMULA: CHARGE: 0
is: HMDB02704
has only substance units: false

metaR r1593
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
reactant: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_b81b2bd7_2a2e_48a7_8473_f89ffc351abb
name: CYP27A1
has only substance units: false
is: Q02318
is encoded by: hsa:1593
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_9bf677c6_0aac_451f_85d3_eda03ea76356
boundary condition: true
is encoded by: hsa:6534
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: SLC6A7
is: Q99884
constant: false
initial concentration: NaN
type: Species

metaR FRUt4
is: SBO:0000185
type: Reaction
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110053#
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
name: D-fructose transport via sodium cotransport

metaM frdp x
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
has only substance units: false
constant: false
name: farnesyl pyrophosphate(3-)
is: CHEBI:175763
boundary condition: false
initial concentration: 1.0
is: HMDB00961
type: Species

metaR DOLPMT3 Uer
product: MODEL1310110053#
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.260
reactant: MODEL1310110053#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is: SBO:0000176
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000

metaR G14T13g
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
reactant: MODEL1310110053#
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false

metaM val L m
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial concentration: 1.0
is: HMDB00883
initial amount: NaN
name: L-valine
constant: false
boundary condition: false
is: CHEBI:16414

http://identifiers.org/biomodels.db/MODEL1310110053#_9eda5408_7a4b_43ed_9e52_bb7a3484d73c
name: LDHA
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3939
is: SBO:0000252
type: Species
is: P00338

http://identifiers.org/biomodels.db/MODEL1310110053#_cd627e72_d79f_4cf8_8a35_debcf5cbb453
is encoded by: hsa:56474
initial amount: NaN
is: Q9NRF8
is: SBO:0000252
boundary condition: true
type: Species
name: CTPS2
has only substance units: false
initial concentration: NaN
constant: false

metaR r0051
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
type: Reaction
is: SBO:0000176
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false
reactant: MODEL1310110053#
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.1.3.5

metaR URATEt
fast: false
product: MODEL1310110053#
name: urate export from cytosol
type: Reaction
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_ad028b13_d373_465e_9d0d_5a47bc0254e8
initial amount: NaN
name: PSPH
constant: false
boundary condition: true
is: P78330
initial concentration: NaN
type: Species
is encoded by: hsa:5723
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_5a76ecf5_1c32_481a_84de_1bcd900162d6
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
name: BCAT1
is: SBO:0000252
is: P54687
has only substance units: false
boundary condition: true
is encoded by: hsa:586

metaM inost c
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:17268
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: HMDB00211
boundary condition: false
name: myo-inositol

metaR FAEL183
modifier: MODEL1310110053#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
fast: false
name: fatty-acyl-CoA elongation (n-C18:3CoA)
kinetic law: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
reversible: false
product: MODEL1310110053#
is described by: ECO:0000000

metaM dhf c
name: 7,8-Dihydrofolate
constant: false
initial amount: NaN
is: C00415
is: CHEBI:57451
has only substance units: false
initial concentration: 1.0
is: HMDB01056
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: SBO:0000247
type: Species
boundary condition: false

metaR GLCAASE1ly
kinetic law: MODEL1310110053#
name: beta-glucuronidase, lysosomal
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110053#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.31
reactant: MODEL1310110053#
is: SBO:0000176
modifier: MODEL1310110053#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_7bdf793f_0e20_4898_a977_32f9cc900e68
has only substance units: false
is: Q6LEN5
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
name: CHAT
is encoded by: hsa:1103

metaR r2110
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110053#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110053#
reactant: MODEL1310110053#
modifier: MODEL1310110053#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR G16MT U
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
fast: false
type: Reaction
reactant: MODEL1310110053#
name: Glycolipid 1,6-alpha-D-mannosyltransferase (uterus)
reversible: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110053#
kinetic law: MODEL1310110053#

metaR TPI
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.1.1
type: Reaction
name: triose-phosphate isomerase
reactant: MODEL1310110053#
is: SBO:0000176
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
product: MODEL1310110053#
fast: false
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
reversible: true

metaM thym c
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: HMDB00262
constant: false
type: Species
initial concentration: 1.0
is: C00178
name: Thymine
is: SBO:0000247
is: CHEBI:17821

metaR r0962
type: Reaction
name: Facilitated diffusion
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
reversible: false
product: MODEL1310110053#
is described by: ECO:0000000
fast: false

metaM udpglcur c
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:58052
initial concentration: 1.0
is: C00167
type: Species
name: UDP-D-glucuronate
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: HMDB00935

metaR RE0452M
type: Reaction
reversible: true
name: RE0452
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
fast: false
product: MODEL1310110053#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110053#

metaR G14T12g
reactant: MODEL1310110053#
reversible: false
modifier: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaR r1592
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110053#
product: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true

metaM dcyt n
boundary condition: false
initial amount: NaN
is: CHEBI:15698
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00014
is: SBO:0000247
name: 2'-deoxycytidine
constant: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881

http://identifiers.org/biomodels.db/MODEL1310110053#_6e4fe934_19ac_4b9c_8c1e_3e76733a5ed1
initial concentration: NaN
name: PYCRL
initial amount: NaN
has only substance units: false
is: Q53H96
is encoded by: hsa:65263
constant: false
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_5bae67e9_010f_4631_8a07_cf2140607041
initial concentration: NaN
has only substance units: false
name: SGPP2
constant: false
is: Q8IWX5
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:130367
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_6441ed46_6bfa_4cae_848c_6939a109e19c
has only substance units: false
name: NT5C
initial concentration: NaN
type: Species
is: Q8TCD5
is encoded by: hsa:30833
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110053#_49451458_e6cd_441a_95dc_078c796b554e
initial amount: NaN
is: P04746
name: AMY2A
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:279
type: Species

metaM uacgam c
constant: false
initial concentration: 1.0
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: HMDB00290
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:57705
has only substance units: false
is: SBO:0000247
name: UDP-N-acetyl-alpha-D-glucosamine(2-)

metaM dhf e
constant: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
name: dihydrofolate(2-)
is: CHEBI:57451
is: HMDB01056

http://identifiers.org/biomodels.db/MODEL1310110053#_a635d578_1f26_4089_b599_6b932d572d14
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:56954
boundary condition: true
name: NIT2
initial amount: NaN
is: Q9NQR4
type: Species
constant: false

metaM 4ppan c
initial concentration: 1.0
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
name: D-4'-Phosphopantothenate
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:10986
is: HMDB01016
initial amount: NaN
constant: false
is: C03492
type: Species

metaM ahcys c
initial concentration: 1.0
has only substance units: false
is: C00021
name: S-Adenosyl-L-homocysteine
type: Species
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: HMDB00939
is: SBO:0000247
is: CHEBI:16680
boundary condition: false
constant: false
initial amount: NaN

metaR A MANASEly
fast: false
name: alpha-mannosidase, lysosomal
modifier: MODEL1310110053#
is: SBO:0000176
reversible: false
reactant: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/3.2.1.24
type: Reaction
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
product: MODEL1310110053#

metaR r0603
fast: false
modifier: MODEL1310110053#
reactant: MODEL1310110053#
type: Reaction
product: MODEL1310110053#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.12
is: SBO:0000176
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
kinetic law: MODEL1310110053#

metaR FAEL184
kinetic law: MODEL1310110053#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
name: fatty-acyl-CoA elongation (n-C20:4CoA)
modifier: MODEL1310110053#
product: MODEL1310110053#
fast: false
type: Reaction
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ

metaR DOLP Uter
type: Reaction
reactant: MODEL1310110053#
fast: false
is described by: ECO:0000000
name: dolichol phosphate flippase (uterus)
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
kinetic law: MODEL1310110053#
reversible: false
is: SBO:0000176

metaM HC01223 m
type: Species
constant: false
has only substance units: false
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
is: CHEBI:57340
boundary condition: false
initial amount: NaN
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_c6f1e134_db47_4977_81a4_a2940cea95d4
is: SBO:0000252
initial concentration: NaN
name: GGT1
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:2678
is: P19440
initial amount: NaN
type: Species

metaM nicrnt c
constant: false
type: Species
is: CHEBI:57502
boundary condition: false
is: SBO:0000247
is: HMDB01132
initial concentration: 1.0
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
name: Nicotinate D-ribonucleotide
is: C01185
initial amount: NaN
has only substance units: false

metaR r1591
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110053#
is: SBO:0000185
reactant: MODEL1310110053#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110053#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_44346c1e_1358_4c55_add1_7ed32b74e036
is: E7ET30
constant: false
is: SBO:0000252
name: AK3
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:50808
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_7d5913be_83ee_4d4a_90ad_7cbcd74f480d
is: Q7GXZ8
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4513
constant: false
name: COX2

metaR THRGLYexR
fast: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
reversible: true
name: L-threonine/glycine reversible exchange
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110053#
is: SBO:0000185
reactant: MODEL1310110053#

metaM dudp c
is: SBO:0000247
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: C01346
has only substance units: false
constant: false
initial amount: NaN
name: dUDP
boundary condition: false
is: CHEBI:60471
is: HMDB01000
type: Species
initial concentration: 1.0

metaM acetol c
is: HMDB06961
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:27957
type: Species
boundary condition: false
initial amount: NaN
name: hydroxyacetone
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
has only substance units: false

metaR 34HPPte
reactant: MODEL1310110053#
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reversible: true
fast: false
name: Transport of 3-(4-hydroxyphenyl)pyruvate

metaM gmp c
initial concentration: 1.0
initial amount: NaN
name: GMP
is: CHEBI:58115
is: HMDB01397
constant: false
type: Species
is: C00144
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR GLUDxm
modifier: MODEL1310110053#
name: glutamate dehydrogenase (NAD) (mitochondrial)
type: Reaction
kinetic law: MODEL1310110053#
is: SBO:0000176
product: MODEL1310110053#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
reactant: MODEL1310110053#
is version of: http://identifiers.org/ec-code/1.4.1.3
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110053#_720087a6_c4fe_4711_99cb_913776145c9f
boundary condition: true
name: ALAS1
has only substance units: false
is encoded by: hsa:211
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q5JAM2
constant: false
initial amount: NaN

metaR BDHm
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.30
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
modifier: MODEL1310110053#
reactant: MODEL1310110053#
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
product: MODEL1310110053#
reversible: true
kinetic law: MODEL1310110053#

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaR r0960
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
type: Reaction
reactant: MODEL1310110053#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
kinetic law: MODEL1310110053#
fast: false
is: SBO:0000185
product: MODEL1310110053#

metaR RTOTALt
is described by: ECO:0000000
reactant: MODEL1310110053#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110053#
name: RTOTAL transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110053#
fast: false

metaM CE2421 m
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
boundary condition: false
has only substance units: false
is: CHEBI:30623
type: Species
name: (3S)-3-hydroxylinoleoyl-CoA
is: HMDB02329
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_a7f9661d_2aa7_494b_9c00_57249865b3e3
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
name: GGT3P
is encoded by: hsa:2679
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_5a2fcbb9_abb8_4199_bcb7_97c73f209d81
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is: Q53F23
initial concentration: NaN
is: SBO:0000252
constant: false
name: TBXAS1
is encoded by: hsa:6916

metaR ACGAMPM
is: SBO:0000176
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110053#
fast: false
name: phosphoacetylglucosamine mutase
is version of: http://identifiers.org/ec-code/5.4.2.3
product: MODEL1310110053#
reversible: true
type: Reaction
modifier: MODEL1310110053#

metaR r1377
is described by: ECO:0000000
reactant: MODEL1310110053#
reversible: true
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
kinetic law: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
fast: false
product: MODEL1310110053#

metaR q10tm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
type: Reaction
name: transport of ubiquinone into mitochondria
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_809b1e9d_6edb_4335_b514_b4ad7a3e6bd2
constant: false
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:9365
boundary condition: true
name: KL
is: SBO:0000252
is: Q9UEF7
initial concentration: NaN

metaR SADT
fast: false
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.25
is: SBO:0000176
product: MODEL1310110053#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
reversible: false
reactant: MODEL1310110053#
name: sulfate adenylyltransferase

http://identifiers.org/biomodels.db/MODEL1310110053#_4fdd3373_0141_43ac_9c50_708354f157b7
constant: false
initial concentration: NaN
is: B4DK61
initial amount: NaN
is encoded by: hsa:51
name: ACOX1
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_cca9abba_0908_44c2_ab62_8fe8b92ff145
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
name: CMA1
constant: false
initial amount: NaN
is encoded by: hsa:1215
has only substance units: false
is: Q4FEB3

metaR GALSIDEtg
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
fast: false
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
name: galactocerebroside intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110053#_e3177e10_8b48_46c5_8eb5_731084ed1040
initial concentration: NaN
has only substance units: false
is encoded by: hsa:206358
type: Species
is: Q1LZ56
name: SLC36A1
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true

metaR CYTK10
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000176
product: MODEL1310110053#
is described by: ECO:0000269
name: cytidylate kinase (CMP,dGTP)
reversible: true
modifier: MODEL1310110053#

metaM HC01672 c
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:37666
name: Acetyl adenylate
has only substance units: false
boundary condition: false
notes: FORMULA: C12H15N5O8P CHARGE: -1 INCHI: InChI=1S/C12H16N5O8P/c1-5(18)25-26(21,22)23-2-6-8(19)9(20)12(24-6)17-4-16-7-10(13)14-3-15-11(7)17/h3-4,6,8-9,12,19-20H,2H2,1H3,(H,21,22)(H2,13,14,15)/t6-,8-,9-,12-/m1/s1 EHMN_ABBREVIATION: C05993
type: Species
initial amount: NaN

metaR GLNtN1
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
fast: false
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110053#
is: SBO:0000185
type: Reaction
product: MODEL1310110053#
name: Glutamine transport (Na, H coupled)
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_7c91beda_b91a_4f57_8998_1b7cc2ccf4bd
is: SBO:0000252
initial amount: NaN
name: PLCD3
has only substance units: false
is encoded by: hsa:113026
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: Q8N3E9

http://identifiers.org/biomodels.db/MODEL1310110053#_9bedaaa3_08e9_4884_8712_dd95a4f37ff5
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: Q67FW5
is encoded by: hsa:146712
has only substance units: false
is: SBO:0000252
type: Species
name: B3GNTL1

http://identifiers.org/biomodels.db/MODEL1310110053#_2d1ac740_97e5_45cf_96aa_20da258434a8
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
name: SDS
is: P20132
is encoded by: hsa:10993
is: SBO:0000252

metaM gluala e
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
is: C03740
boundary condition: false
is: HMDB06248
has only substance units: false
is: http://identifiers.org/pubchem.compound/6503
name: 5-L-Glutamyl-L-alanine
type: Species
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740

http://identifiers.org/biomodels.db/MODEL1310110053#_77dbea60_fac2_44d0_8450_060792c3571d
type: Species
is: SBO:0000252
name: PISD
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:23761
is: Q9UG56
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_8927c569_f727_436d_b65f_91b880c28cbc
type: Species
initial amount: NaN
is: P07686
name: HEXB
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3074
constant: false
has only substance units: false

metaM man l
initial concentration: 1.0
name: D-mannose
boundary condition: false
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: HMDB00169
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: CHEBI:16024

metaR r1378
is described by: ECO:0000000
kinetic law: MODEL1310110053#
fast: false
reversible: true
type: Reaction
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
is: SBO:0000176
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_da65d4a8_8120_4cf9_b1ac_d1082a19f5e3
constant: false
name: GALK2
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2585
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN

metaR r0399
is version of: http://identifiers.org/ec-code/1.2.4.2
modifier: MODEL1310110053#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110053#
reactant: MODEL1310110053#
fast: false
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
kinetic law: MODEL1310110053#

metaR DM atp c
kinetic law: MODEL1310110053#
fast: false
is described by: ECO:0000134
reversible: false
name: DM_atp(c)
reactant: MODEL1310110053#
is: SBO:0000176
type: Reaction
product: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110053#_be0918c5_5c08_435b_bec4_084cbe88e296
initial amount: NaN
type: Species
has only substance units: false
name: ST3GAL3
constant: false
initial concentration: NaN
is encoded by: hsa:6487
is: SBO:0000252
boundary condition: true

metaM sarcs e
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
is: HMDB00271
name: sarcosine
initial amount: NaN
is: CHEBI:15611
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110053#_831a7439_5e30_4a72_98c4_b9e5b30e8c8d
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: P52790
initial concentration: NaN
name: HK3
constant: false
is encoded by: hsa:3101

http://identifiers.org/biomodels.db/MODEL1310110053#_db21d57a_b315_41c8_80a0_621f29818675
is encoded by: hsa:10195
has only substance units: false
name: ALG3
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110053#_937f85b6_52a9_4c4c_95cd_f66a5d9ce89e
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:79695
initial amount: NaN
name: GALNT12
initial concentration: NaN
constant: false
is: Q8IXK2
is: SBO:0000252

metaR DNDPt8m
fast: false
type: Reaction
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is described by: ECO:0000269
reactant: MODEL1310110053#
name: dADP transport via dUDP antiport

metaR S6T4g
type: Reaction
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110053#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_29e530dc_04d0_4238_9065_4c20c831f23d
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: EHHADH
has only substance units: false
is encoded by: hsa:1962
is: Q9NY65
type: Species
initial amount: NaN
constant: false

metaM acnam c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00230
is: SBO:0000247
is: CHEBI:35418
name: N-acetylneuraminate
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
constant: false
boundary condition: false
type: Species

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_5cfd60ef_1fe9_4172_a33b_116d818e4fc4
has only substance units: false
is encoded by: hsa:AA278423
type: Species
boundary condition: true
initial amount: NaN
name: _AA278423_1_m
constant: false
initial concentration: NaN
is: SBO:0000252

metaM vitd3 c
is: SBO:0000247
name: calciol
constant: false
has only substance units: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
is: CHEBI:28940
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00876
type: Species

metaM 5thf e
boundary condition: false
initial amount: NaN
is: HMDB06487
has only substance units: false
notes: FORMULA: C39H45N11O18 CHARGE: -6
is: SBO:0000247
type: Species
name: pentaglutamyl folate (THF)
constant: false
initial concentration: 1.0

metaM mthgxl c
constant: false
name: methylglyoxal
initial concentration: 1.0
is: CHEBI:17158
has only substance units: false
boundary condition: false
is: HMDB01167
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546

metaR NRPPHRSULT
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
is version of: http://identifiers.org/ec-code/2.8.2.1
name: Norepinephrine Sulfotransferase
fast: false
is: SBO:0000176
product: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#

metaM oh1 c
is: C01328
notes: FORMULA: HO CHARGE: -1
boundary condition: false
constant: false
is: HMDB01039
name: hydroxide ion
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false

metaR r1019
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
kinetic law: MODEL1310110053#
name: Postulated transport reaction
reactant: MODEL1310110053#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_4aaa98ee_610f_43cd_8c77_17bb9ecfcadd
is: SBO:0000252
initial amount: NaN
name: SDHB
is: P21912
is encoded by: hsa:6390
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
constant: false

metaM fol m
constant: false
type: Species
name: Folate
is: SBO:0000247
boundary condition: false
is: CHEBI:27470
initial amount: NaN
notes: FORMULA: C19H18N7O6 CHARGE: -1 INCHI: InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00396 EHMN_ABBREVIATION: C00504
is: HMDB00121
has only substance units: false
initial concentration: 1.0

metaR MANtly
reactant: MODEL1310110053#
reversible: false
product: MODEL1310110053#
is described by: ECO:0000000
type: Reaction
name: mannose efflux from lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
kinetic law: MODEL1310110053#
fast: false
is: SBO:0000185

metaR GGLUCT
is version of: http://identifiers.org/ec-code/2.3.2.4
product: MODEL1310110053#
name: gamma-glutamylcyclotransferase
is: SBO:0000185
kinetic law: MODEL1310110053#
reversible: false
reactant: MODEL1310110053#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
type: Reaction
fast: false
modifier: MODEL1310110053#

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

metaR RE3524R
reversible: true
product: MODEL1310110053#
kinetic law: MODEL1310110053#
is described by: ECO:0000000
reactant: MODEL1310110053#
fast: false
is: SBO:0000176
name: RE3524
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
type: Reaction

metaM ump r
is: SBO:0000247
is: CHEBI:57865
is: HMDB00288
boundary condition: false
initial concentration: 1.0
name: UMP
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaR DGULND
is described by: ECO:0000000
fast: false
reactant: MODEL1310110053#
name: dehydro-L-gulonate decarboxylase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
kinetic law: MODEL1310110053#
is: SBO:0000176
product: MODEL1310110053#
reversible: true
type: Reaction

metaR KCCt
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
modifier: MODEL1310110053#
type: Reaction
reactant: MODEL1310110053#
product: MODEL1310110053#
reversible: true
fast: false
kinetic law: MODEL1310110053#
is: SBO:0000185
name: K+-Cl- cotransport

metaM inost e
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
constant: false
is: HMDB00211
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
name: myo-inositol
is: CHEBI:17268
boundary condition: false
has only substance units: false

metaR HSPASEly
kinetic law: MODEL1310110053#
name: heparan sulfate proteoglycan protease, lysosome (endosome)
reactant: MODEL1310110053#
fast: false
product: MODEL1310110053#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
is described by: ECO:0000000
is: SBO:0000176

metaM thym m
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
type: Species
boundary condition: false
is: HMDB00262
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:17821
name: thymine

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

metaR r2329
type: Reaction
reversible: true
product: MODEL1310110053#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185

metaM leuktrD4 c
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB03080
constant: false
has only substance units: false
name: Leukotriene D4
boundary condition: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: CHEBI:28666

metaR GLCt4
fast: false
type: Reaction
name: glucose transport via sodium symport
reactant: MODEL1310110053#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
reversible: true
is: SBO:0000185
product: MODEL1310110053#
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#

metaR r1018
is: SBO:0000185
product: MODEL1310110053#
name: Transport reaction
kinetic law: MODEL1310110053#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reactant: MODEL1310110053#
fast: false
is described by: ECO:0000000

metaM dhbpt c
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00038
is: SBO:0000247
boundary condition: false
is: CHEBI:20680
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
name: 6,7-dihydrobiopterin
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_489717af_8042_4843_beaa_6e81abdda3a1
type: Species
has only substance units: false
is encoded by: hsa:10317
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: B3GALT5
constant: false
is: SBO:0000252

metaR M1316Mg
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
product: MODEL1310110053#
reversible: false
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.114
is described by: ECO:0000000
kinetic law: MODEL1310110053#
type: Reaction
modifier: MODEL1310110053#
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_8d6ea86b_7c08_4792_baec_1415d1c83a9c
has only substance units: false
name: PLCB3
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:5331
is: G5E960
boundary condition: true
constant: false

metaM sarcs c
type: Species
is: HMDB00271
notes: FORMULA: C3H7NO2 CHARGE: 0
is: CHEBI:3513
initial amount: NaN
is: C00213
name: Sarcosine
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_3a0b03d7_fadc_4c55_a94c_fdd46a8176b2
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:80025
name: PANK2
initial amount: NaN

metaR r2328
type: Reaction
product: MODEL1310110053#
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185

metaM C05965 e
name: 12(S)-HPETE(1-)
constant: false
is: HMDB04243
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:57444
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_c5d82d33_89fb_44d1_876c_b9d6f672ea59
is encoded by: hsa:65010
initial concentration: NaN
initial amount: NaN
constant: false
is: Q9Y3Y1
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
name: SLC26A6

metaM vitd3 e
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
name: calciol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
has only substance units: false
initial amount: NaN
is: CHEBI:28940
type: Species
is: HMDB00876

metaR r0541
reversible: true
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000176
type: Reaction
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7

metaR NH4tn
reactant: MODEL1310110053#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110053#
name: ammonia nuclear transport
kinetic law: MODEL1310110053#

metaR Asn X Ser Thrtr
reversible: true
name: Asn-X-Ser/Thr transport (from ER to lysosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_a7a4cb13_cc55_4fa1_8611_60f052eb0804
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AW299740
initial amount: NaN
name: _AW299740_1_m

http://identifiers.org/biomodels.db/MODEL1310110053#_70647923_01b8_4930_bb11_4b839e945e9a
has only substance units: false
is: Q6NSB3
boundary condition: true
type: Species
constant: false
name: AMY1A
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:276

http://identifiers.org/biomodels.db/MODEL1310110053#_3294a36a_7045_4b35_ac52_05fe24db9dd4
is encoded by: hsa:H77542
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: _H77542_1_c
initial amount: NaN
boundary condition: true
constant: false

metaR BAAT2x
is: SBO:0000176
reversible: false
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110053#
name: bile acid Coenzyme A: amino acid N-acyltransferase
product: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_8dbc5d03_e776_4e7c_8512_e9408348eb9e
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI697028
name: _AI697028_1_m
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN

metaR HGNTOR
kinetic law: MODEL1310110053#
fast: false
modifier: MODEL1310110053#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/1.13.11.5
is: SBO:0000176
product: MODEL1310110053#
reactant: MODEL1310110053#
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
type: Reaction
reversible: false

metaR OCDCAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110053#
is: SBO:0000185
name: fatty acid transport via diffusion
kinetic law: MODEL1310110053#
product: MODEL1310110053#

metaR CYTK14
name: cytidylate kinase (dCMP,UTP)
modifier: MODEL1310110053#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is: SBO:0000176
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110053#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110053#_5ad7b130_3e39_407d_aedd_26b8a73a23af
is encoded by: hsa:55350
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: VNN3
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_355004e2_1e3f_4542_b644_fc7003dc2996
name: NMNAT3
type: Species
initial amount: NaN
is encoded by: hsa:349565
has only substance units: false
is: Q96T66
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252

metaR RE1903R
name: RE1903
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110053#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:

metaM ptrc e
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
is: HMDB01414
type: Species
initial concentration: 1.0
is: CHEBI:326268
initial amount: NaN
has only substance units: false
constant: false
is: C00134
boundary condition: false
name: Putrescine
is: SBO:0000247

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaR r2327
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110053#
is described by: ECO:0000000
kinetic law: MODEL1310110053#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction

metaM dhcrm hs c
type: Species
initial concentration: 1.0
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
name: dihydroceramide
is: CHEBI:31488
constant: false

metaM hco3 c
boundary condition: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: C00288
type: Species
name: Bicarbonate
constant: false
initial amount: NaN
is: HMDB00595
is: CHEBI:17544
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_55ea61f7_b8df_41eb_a9c2_4ec8d748f01f
is: B3KT70
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:80201
type: Species
name: HKDC1

metaR ECOAH1m
reactant: MODEL1310110053#
fast: false
reversible: true
product: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
kinetic law: MODEL1310110053#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.18
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110053#_6812762e_2de7_41c4_8c1f_42c4c723d422
has only substance units: false
initial amount: NaN
is encoded by: hsa:3990
initial concentration: NaN
type: Species
is: A6H8L5
is: SBO:0000252
boundary condition: true
constant: false
name: LIPC

http://identifiers.org/biomodels.db/MODEL1310110053#_048c26c4_ab7e_4779_8887_3095a25c3f5c
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
name: RDH13
initial amount: NaN
type: Species
is: B3KVA3
is encoded by: hsa:112724

metaR GLYKm
modifier: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (2710.2) or (2712.1) or (2710.1) or (2713.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.30 Confidence Level: 2 AUTHORS: PMID:7987308 NOTES:TV
is version of: http://identifiers.org/ec-code/2.7.1.30
fast: false
reversible: false
kinetic law: MODEL1310110053#
product: MODEL1310110053#
name: glycerol kinase
is described by: ECO:0000254
type: Reaction
is: SBO:0000176

metaM leuktrD4 e
constant: false
name: Leukotriene D4
has only substance units: false
type: Species
is: CHEBI:28666
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB03080
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110053#_7b6ed3ef_6c2d_4bd1_baab_97417b0b5fb6
initial amount: NaN
has only substance units: false
name: ABAT
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:18
boundary condition: true
is: P80404
initial concentration: NaN

metaM ksi pre5 g
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 5
initial amount: NaN
notes: FORMULA: C101H164N7O75SX CHARGE: -2
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110053#_c17ff28d_c030_4dec_b467_0834c0d57b68
type: Species
initial concentration: NaN
is: Q6NVY1
boundary condition: true
has only substance units: false
constant: false
name: HIBCH
is encoded by: hsa:26275
initial amount: NaN
is: SBO:0000252

metaM 5aop m
has only substance units: false
type: Species
is: HMDB01149
is: C00430
boundary condition: false
initial amount: NaN
is: CHEBI:17549
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
initial concentration: 1.0
constant: false
is: SBO:0000247
name: 5-Amino-4-oxopentanoate

http://identifiers.org/biomodels.db/MODEL1310110053#_c533bed2_cce8_4675_bb09_57f6c64924b1
is: SBO:0000252
initial concentration: NaN
constant: false
name: SLC17A3
initial amount: NaN
is: O00476
boundary condition: true
has only substance units: false
is encoded by: hsa:10786
type: Species

metaR CYTK13
type: Reaction
reactant: MODEL1310110053#
kinetic law: MODEL1310110053#
modifier: MODEL1310110053#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110053#
fast: false
is: SBO:0000176
name: cytidylate kinase (dCMP,dATP)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR CYTDt
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
modifier: MODEL1310110053#
is described by: ECO:0000269
name: cytidine facilated transport in cytosol
kinetic law: MODEL1310110053#
product: MODEL1310110053#
fast: false
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_61094699_1fbc_4dad_803b_0a8ea1724476
is: A0PJJ9
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2686
is: SBO:0000252
name: GGT7
initial amount: NaN
constant: false
has only substance units: false

metaM pail45p hs n
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: phosphatidylinositol 4,5-bisphosphate
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: CHEBI:28910
type: Species
is: SBO:0000247
boundary condition: false
constant: false

metaR PSt3
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110053#
fast: false
type: Reaction
name: phosphatidylserine transport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110053#
product: MODEL1310110053#

http://identifiers.org/biomodels.db/MODEL1310110053#_4c233d24_2cdd_4622_9619_e3d3ed61e811
boundary condition: true
name: EHHADH
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1962
type: Species
initial concentration: NaN
initial amount: NaN
is: Q9NY65
constant: false

metaM 5mdr1p c
type: Species
initial amount: NaN
is: CHEBI:58533
is: C04188
is: HMDB00963
is: SBO:0000247
name: 5-Methylthio-5-deoxy-D-ribose 1-phosphate
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H11O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02120 EHMN_ABBREVIATION: C04188
boundary condition: false
constant: false

metaR CYTK12
modifier: MODEL1310110053#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reactant: MODEL1310110053#
fast: false
name: cytidylate kinase (dCMP,dCTP)
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110053#
product: MODEL1310110053#
reversible: true

metaR r2326
product: MODEL1310110053#
type: Reaction
kinetic law: MODEL1310110053#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110053#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaM xu5p D c
initial concentration: 1.0
boundary condition: false
is: CHEBI:57737
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: D-xylulose 5-phosphate(2-)
is: HMDB00868

metaM man g
boundary condition: false
is: CHEBI:16024
is: HMDB00169
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
name: D-mannose
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110053#_204ec49a_11e0_49d4_b3f8_4550f647d524
name: COX7A2
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1347
constant: false
is: H0UI06
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110053#_f6b59a07_1b5d_4a64_8ca0_6f71515fecb0
type: Species
has only substance units: false
name: ENPP3
is: Q308M7
is encoded by: hsa:5169
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

metaR r0317
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.8.1.4
fast: false
is version of: http://identifiers.org/ec-code/1.4.4.2
modifier: MODEL1310110053#
is version of: http://identifiers.org/ec-code/2.1.2.10
is: SBO:0000176
product: MODEL1310110053#
is described by: ECO:0000000
type: Reaction

metaR r1668
is: SBO:0000185
product: MODEL1310110053#
fast: false
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reversible: true
modifier: MODEL1310110053#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110053#_ab1742a0_3841_4709_b89f_aea2da384423
constant: false
name: RPE
initial concentration: NaN
boundary condition: true
is: Q53TV9
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:6120

metaR SPC HSt
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110053#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
reversible: true
product: MODEL1310110053#
fast: false
name: sphingosylphosphorylcholine transport (diffusion)
kinetic law: MODEL1310110053#

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaR EX 1glyc hs LPAREN e RPAREN
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1 acyl phosphoglycerol exchange
type: Reaction

metaM dhf m
name: dihydrofolate(2-)
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57451
is: HMDB01056
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
constant: false
is: SBO:0000247

metaM 4aphdob c
is: CHEBI:58147
initial concentration: 1.0
constant: false
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
is: HMDB00978

http://identifiers.org/biomodels.db/MODEL1310110053#_f4f897fa_339e_4282_a80a_38c32b1c44d8
type: Species
name: _T83654_1_e
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:T83654
is: SBO:0000252

metaR ECOAH9m
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110053#
fast: false
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
product: MODEL1310110053#
modifier: MODEL1310110053#
reactant: MODEL1310110053#

MODEL1310110053#
species: metaM hco3 c
species: metaM r1p c
species: metaM ppi x
species: metaM cyan m
species: metaM duri e
species: metaM ptrc e
species: metaM amp x
species: metaM cys L e
species: metaM ser L e
species: metaM dolmanp U c
species: metaM mmcoa R m
species: metaM co2 e
species: metaM cmp e
species: metaM dhf m
species: metaM pan4p m
species: metaM betald m
species: metaM arachcrn m
species: metaM ala B e
species: metaM crm hs r
species: metaM chol m
species: metaM pa hs c
species: metaM ppcoa c
species: metaM h g
species: metaM accoa m
species: metaM h x
stoichiometry: 0.013183
species: metaM 34dhpha c
species: metaM glyc c
species: metaM HC00319 m
species: metaM bilirub e
species: metaM 5fthf m
species: metaM pro D e
species: metaM frdp c
species: metaM HC01231 c
species: metaM ksi pre8 g
species: metaM ctp m
constant: false
species: metaM acnam c
species: metaM cholate c
species: metaM dtdp c
species: metaM dpcoa m
species: metaM mthgxl c
species: metaM dttp n
species: metaM acac c
species: metaM dgdp n
species: metaM crn r
stoichiometry: 0.592114
species: metaM gluside hs g
species: metaM hs l
species: metaM dgmp e
species: metaM gluside hs r
species: metaM abt c
species: metaM galgluside hs g
species: metaM nad x
species: metaM man l
multipler: 1.0
species: metaM ha pre1 l
species: metaM HC02206 c
species: metaM tsul e
species: metaM h m
species: metaM udpglcur r
species: metaM glx c
species: metaM lnlncg r
species: metaM prostgi2 c
species: metaM ump g
stoichiometry: 8.0
species: metaM pacald c
species: metaM nm2masn g
species: metaM ach e
species: metaM icit c
species: metaM malcoa e
species: metaM Lcystin e
species: metaM ppa c
species: metaM gluala e
species: metaM fmn c
species: metaM g1m8mpdol U r
species: metaM ppi m
species: metaM atp e
species: metaM hom L e
species: metaM leu L c

metaR ACACt2m
fast: false
product: MODEL1310110053#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
name: Acetoacetate mitochondrial transport via H+ symport
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
modifier: MODEL1310110053#
reversible: true

metaR r0394
kinetic law: MODEL1310110053#
reactant: MODEL1310110053#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110053#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
type: Reaction

metaM tststerone c
name: testosterone
has only substance units: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial amount: NaN
is: HMDB00234
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:17347
type: Species
boundary condition: false

metaM hco3 e
is: C00288
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00595
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
name: Bicarbonate
is: CHEBI:17544
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR GDPFUCtg
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110053#
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
fast: false
name: GDPFuc Golgi transport via CMP antiport
product: MODEL1310110053#
modifier: MODEL1310110053#
reversible: true
reactant: MODEL1310110053#
is described by: ECO:0000269

metaR CYTK11
reactant: MODEL1310110053#
reversible: true
fast: false
name: cytidylate kinase (dCMP,dGTP)
is described by: ECO:0000269
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
product: MODEL1310110053#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR r2325
type: Reaction
product: MODEL1310110053#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110053#
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110053#

metaR ORNt4m
product: MODEL1310110053#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110053#
name: ornithine mitochondrial transport exchange with citruline
modifier: MODEL1310110053#
kinetic law: MODEL1310110053#
fast: false