metaR TETPENT6COAtx
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
reactant: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false

metaR GTHO
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.7
kinetic law: MODEL1310110052#
is: SBO:0000176
modifier: MODEL1310110052#
is described by: ECO:0000254
product: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
name: glutathione oxidoreductase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110052#_ed0ce936_e3dd_4c36_b2c3_b40aea4d1fb2
has only substance units: false
has part: Q8TBF5
is: SBO:0000297
initial amount: NaN
constant: false
has part: Q9H3S5
boundary condition: true
is encoded by: hsa:93183
type: Species
is encoded by: hsa:54965
name: PIGX:PIGM
initial concentration: NaN

metaM CE5126 x
type: Species
name: (2R)-pristanoyl-CoA
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:15748
boundary condition: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5126
is: HMDB00127
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_3da48c7e_2d29_4eff_9145_a5097f17dea6
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:122622
has only substance units: false
boundary condition: true
name: ADSSL1
is: B3KTV4
constant: false

metaR HTDCRNe
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-tetradecanoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_1bb5bfde_ab94_42de_bb9e_b5f88d2bc2d0
name: _U37519_1_m
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:U37519

metaR r2382
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000185
reactant: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110052#
product: MODEL1310110052#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_9c33b130_c803_4388_b444_362784f4d8bb
is encoded by: hsa:8693
name: GALNT4
constant: false
initial amount: NaN
is: SBO:0000252
is: Q8N4A0
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_5a1fc2e6_80b3_4a73_8338_8bbe86adad62
is encoded by: hsa:4967
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q02218
has only substance units: false
name: OGDH
initial amount: NaN

metaR r0186
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110052#
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
product: MODEL1310110052#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
fast: false
kinetic law: MODEL1310110052#
is: SBO:0000176
modifier: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_26195f10_5768_442a_b4ba_27e9a3f90153
initial amount: NaN
has only substance units: false
is: Q9Y5P6
type: Species
name: GMPPB
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:29925
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_fa91521a_c0d8_4827_8604_5bbf704ca779
is encoded by: hsa:56474
is: Q9NRF8
type: Species
initial concentration: NaN
boundary condition: true
constant: false
name: CTPS2
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_3947a6b7_104b_4154_8eae_3047a5e44d95
is: Q99714
constant: false
name: HSD17B10
is: SBO:0000252
is encoded by: hsa:3028
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_73892a07_bed4_4bb7_834a_e6932292ce1c
type: Species
name: SLC4A5
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:57835
boundary condition: true

metaM malcoa c
is: CHEBI:57384
has only substance units: false
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
initial amount: NaN
is: C00083
type: Species
is: SBO:0000247
constant: false
is: HMDB01175
name: Malonyl-CoA
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110052#_0f4ded54_185c_4e97_b3d1_70a9a7748ba0
has only substance units: false
is encoded by: hsa:1962
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
name: EHHADH
boundary condition: true
is: Q9NY65
initial amount: NaN

metaM pydam e
is: C00534
is: SBO:0000247
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:57761
name: Pyridoxamine
is: HMDB01431

metaR AG13T15g
product: MODEL1310110052#
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110052#

metaR RE2972M
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.67
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110052#
product: MODEL1310110052#
name: RE2972
reversible: true
modifier: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:

metaM lnlncg l
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: HMDB03073
name: gamma-linolenate
is: SBO:0000247
is: CHEBI:32391
boundary condition: false

metaM ins e
name: Inosine
type: Species
is: C00294
constant: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: CHEBI:17596
initial amount: NaN
is: HMDB00195
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR COQ7m
type: Reaction
fast: false
is described by: ECO:0000269
modifier: MODEL1310110052#
reversible: false
kinetic law: MODEL1310110052#
is: SBO:0000176
name: Ubiquinone biosynthesis COQ7
reactant: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (10229.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.14.13.- IT

metaR SFGTH
reversible: true
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
fast: false
reactant: MODEL1310110052#
is described by: ECO:0000269
name: S-Formylglutathione hydralase
is: SBO:0000176
product: MODEL1310110052#
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.12

http://identifiers.org/biomodels.db/MODEL1310110052#_9c62811b_c87b_46e3_a23a_3dbdbdbbcb04
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
is: D3DWC4
has only substance units: false
is encoded by: hsa:259230
initial concentration: NaN
name: SGMS1
constant: false

metaR ASPTAm
modifier: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#
type: Reaction
name: aspartate transaminase
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
kinetic law: MODEL1310110052#
is described by: ECO:0000269
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
is: SBO:0000176

metaR r0497
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.2.4.2
kinetic law: MODEL1310110052#
product: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
modifier: MODEL1310110052#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
is described by: ECO:0000000
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39

metaR r2380
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110052#_431225be_0c49_4f11_af52_f268ba4191c7
constant: false
is encoded by: hsa:4706
initial concentration: NaN
is: O14561
initial amount: NaN
type: Species
has only substance units: false
name: NDUFAB1
is: SBO:0000252
boundary condition: true

metaM docoscoa x
initial amount: NaN
is: HMDB12930
is: SBO:0000247
has only substance units: false
name: docosanoylcoa
notes: FORMULA: C43H74N7O17P3S CHARGE: -4
type: Species
boundary condition: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110052#_620963c5_5423_4704_a36f_cfd3dc1f01b2
boundary condition: true
constant: false
is: SBO:0000252
name: PIGP
is encoded by: hsa:51227
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN

metaR SMPD3g
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.4.12
is described by: ECO:0000304
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
reversible: false
type: Reaction
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is: SBO:0000176
fast: false
product: MODEL1310110052#

metaR DMNONCRNt
is described by: ECO:0000000
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
name: 4,8 dimethylnonanoyl carnitine transport (mitochondria)
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction

metaR SERDGLNexR
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
name: D-Serine/Glutamine reversible exchange
product: MODEL1310110052#
is: SBO:0000185
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
reversible: true

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR NRVNCCOAtx
type: Reaction
is: SBO:0000185
name: fatty acid intracellular transport
kinetic law: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
is described by: ECO:0000000
reversible: true
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaM 4hbzcoa m
is: SBO:0000247
type: Species
initial concentration: 1.0
name: 4-hydroxybenoyl-CoA
notes: FORMULA: C28H36N7O18P3S CHARGE: -4 INCHI: InChI=1/C28H40N7O18P3S/c1-28(2,22(39)25(40)31-8-7-18(37)30-9-10-57-27(41)15-3-5-16(36)6-4-15)12-50-56(47,48)53-55(45,46)49-11-17-21(52-54(42,43)44)20(38)26(51-17)35-14-34-19-23(29)32-13-33-24(19)35/h3-6,13-14,17,20-22,26,36,38-39H,7-12H2,1-2H3,(H,30,37)(H,31,40)(H,45,46)(H,47,48)(H2,29,32,33)(H2,42,43,44)/t17-,20?,21-,22+,26-/m1/s1
boundary condition: false
initial amount: NaN
is: HMDB06467
has only substance units: false
constant: false

metaM pydam c
is: HMDB01431
is: C00534
has only substance units: false
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
boundary condition: false
is: SBO:0000247
name: Pyridoxamine
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: CHEBI:57761

metaM malcoa e
is: HMDB01175
name: malonyl-CoA(4-)
boundary condition: false
is: SBO:0000247
is: CHEBI:57384
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN

metaR FACOAL224
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
product: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110052#
reversible: true
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_3589e64a_fa61_4534_8fed_8066367f0a54
initial amount: NaN
name: HMGCS1
initial concentration: NaN
is encoded by: hsa:3157
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true

metaR PHEMEt
is described by: ECO:0000269
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
reactant: MODEL1310110052#
fast: false
product: MODEL1310110052#
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
name: heme transport
type: Reaction

metaM subeac x
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: suberic acid
constant: false
notes: FORMULA: C8H12O4 CHARGE: -2
is: SBO:0000247
is: HMDB00893
type: Species
has only substance units: false

metaM ins c
name: Inosine
boundary condition: false
type: Species
is: C00294
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
initial concentration: 1.0
is: HMDB00195
is: CHEBI:17596
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_198def06_1e73_4ba0_b5d1_905a08ae7e91
has only substance units: false
type: Species
is encoded by: hsa:3706
is: SBO:0000252
initial concentration: NaN
name: ITPKA
initial amount: NaN
boundary condition: true
constant: false
is: P23677

http://identifiers.org/biomodels.db/MODEL1310110052#_bf36858a_d3d8_40b3_9397_33d220bc4d4f
name: _T83654_1_e
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:T83654
is: SBO:0000252

metaR AHEXASEly
is described by: ECO:0000000
modifier: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110052#
fast: false
product: MODEL1310110052#

metaM udpglcur c
type: Species
is: SBO:0000247
is: CHEBI:58052
name: UDP-D-glucuronate
boundary condition: false
constant: false
initial concentration: 1.0
is: C00167
initial amount: NaN
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: HMDB00935
has only substance units: false

metaM hxan c
is: SBO:0000247
type: Species
boundary condition: false
is: C00262
initial amount: NaN
initial concentration: 1.0
is: HMDB00157
is: CHEBI:17368
name: Hypoxanthine
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
has only substance units: false
constant: false

metaR C8CRNe
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octanoyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_d88d1e35_d483_4566_9d6d_2b8cde3cc2d9
is: C9JFZ1
type: Species
name: SYNJ1
is encoded by: hsa:8867
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR r0494
kinetic law: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reactant: MODEL1310110052#
fast: false
reversible: true
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_152a0fa8_4e6c_467c_8d10_c974c2c7b886
is: P40879
name: SLC26A3
initial amount: NaN
has only substance units: false
is encoded by: hsa:1811
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true

metaR FAS80COA L
kinetic law: MODEL1310110052#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
type: Reaction
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
fast: false
is described by: ECO:0000269
product: MODEL1310110052#
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_1b18d63d_5e28_4445_bc78_d62616c2da84
initial concentration: NaN
name: PDE9A
boundary condition: true
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:5152
initial amount: NaN

metaR FAOXC16OHC16r
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

metaM thcholstoic r
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
type: Species
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:18402
is: HMDB03873
initial amount: NaN
initial concentration: 1.0

metaR r0181
is described by: ECO:0000000
fast: false
is: SBO:0000176
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
modifier: MODEL1310110052#
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_1c70b957_b5e7_4a1d_ad59_f268fabfb426
name: _AI091231_1_c
initial concentration: NaN
is encoded by: hsa:AI091231
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaR AKGtp
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110052#
product: MODEL1310110052#
name: AKG transporter, peroxisome
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110052#
reversible: true

metaM ksi pre3 g
type: Species
notes: FORMULA: C93H152N6O67X CHARGE: -1
name: keratan sulfate I biosynthesis, precursor 3
is: CHEBI:58053
is: C00130
is: SBO:0000247
boundary condition: false
is: HMDB00175
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR FACOAL226
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
reactant: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110052#
reversible: true
modifier: MODEL1310110052#
type: Reaction
is described by: ECO:0000000

metaR G14T19g
is: SBO:0000176
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
kinetic law: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#

metaR TYMSULT
modifier: MODEL1310110052#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
name: Tyramine Sulfotransferase
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
is version of: http://identifiers.org/ec-code/2.8.2.1
is described by: ECO:0000269
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110052#_a97b45ea_4525_40fe_a5e7_d923d9683c1b
name: IDI2
has only substance units: false
boundary condition: true
is encoded by: hsa:91734
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9BXS1
initial concentration: NaN
constant: false

metaR KHK
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES:NCD
name: ketohexokinase
is: SBO:0000176
type: Reaction
reactant: MODEL1310110052#
reversible: false
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.1.3
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is described by: ECO:0000000
fast: false

metaR r1147
product: MODEL1310110052#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
kinetic law: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110052#

metaR r0308
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
fast: false
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
reversible: false
is: SBO:0000176
product: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#

metaM hxan e
is: HMDB00157
initial amount: NaN
is: CHEBI:17368
name: hypoxanthine
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
boundary condition: false

metaM o2s x
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB02168
is: CHEBI:18421
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
name: superoxide
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_a2246504_9b68_4f5d_bf55_9cbe1a10fc13
name: _H77542_1_c
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:H77542
has only substance units: false

metaR ECOAH1m
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110052#
is: SBO:0000176
modifier: MODEL1310110052#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/4.2.1.18
fast: false
reactant: MODEL1310110052#
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
reversible: true
type: Reaction

metaR FAOXTC101TC102m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:1-->C10:2)m
type: Reaction

metaR HSD17B4x
is: SBO:0000176
modifier: MODEL1310110052#
reversible: false
name: hydroxysteroid (17-beta) dehydrogenase 4
product: MODEL1310110052#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use

metaR EX paf hs LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
type: Reaction

metaR PNTK
reversible: false
name: pantothenate kinase
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.1.33
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
modifier: MODEL1310110052#

metaR GASNASE2ly
fast: false
kinetic law: MODEL1310110052#
reversible: false
is described by: ECO:0000000
type: Reaction
name: glycosylasparaginase, lysosomal
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.5.1.26
reactant: MODEL1310110052#
is: SBO:0000176
modifier: MODEL1310110052#

metaR RETHe
kinetic law: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
is: SBO:0000176
name: retinyl ester hydrolase, extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110052#_eacb019d_7bee_4d7f_8ee5_414ddb0e2612
is: O00483
initial concentration: NaN
is encoded by: hsa:4697
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: NDUFA4
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_61c88f05_75b1_496e_bf91_d51ea9843ac4
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:2589
is: Q10472
is: SBO:0000252
constant: false
type: Species
name: GALNT1

http://identifiers.org/biomodels.db/MODEL1310110052#_10586522_bcbd_4ff5_b1a5_8146284bdbd1
has only substance units: false
boundary condition: true
name: AKR1C1
is: Q04828
is encoded by: hsa:1645
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false

metaR NACHEXA22ly
modifier: MODEL1310110052#
fast: false
reversible: false
name: beta-N-acetylhexosaminidase A, lysosomal
product: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is: SBO:0000176
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR r1148
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110052#
is: SBO:0000185
reactant: MODEL1310110052#
product: MODEL1310110052#
fast: false
reversible: true
name: Active transport

metaM undcoa m
notes: FORMULA: C32H52N7O17P3S CHARGE: -4
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
name: undecanoylcoa
has only substance units: false
is: SBO:0000247
is: HMDB13114
initial amount: NaN

metaM 2octdectecoa m
is: SBO:0000247
boundary condition: false
name: 2,6,9,12-octadecatetraenoylcoa
initial concentration: 1.0
type: Species
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280355
initial amount: NaN

metaM didp n
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB03536
boundary condition: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
type: Species
initial concentration: 1.0
is: CHEBI:28823
constant: false
name: dIDP

metaM 5mta e
is: HMDB01173
has only substance units: false
boundary condition: false
is: C00170
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
name: 5-Methylthioadenosine
is: CHEBI:17509
notes: FORMULA: C11H15N5O3S CHARGE: 0

metaR CYANtm
name: Cyanide transport via diffusion (mitochondrial)
product: MODEL1310110052#
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
type: Reaction

metaR EX leuleu LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylleucine
type: Reaction

metaR RE3245C
type: Reaction
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
reactant: MODEL1310110052#
product: MODEL1310110052#
name: RE3245
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: true

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_7e3c0143_5035_4ef6_b26d_e29af25c17fb
type: Species
initial amount: NaN
is encoded by: hsa:953
name: ENTPD1
is: Q86VV3
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false

metaM thcholstoic x
initial concentration: 1.0
is: SBO:0000247
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
boundary condition: false
has only substance units: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
type: Species
is: CHEBI:18402
constant: false
initial amount: NaN
is: HMDB03873

metaM ctp m
has only substance units: false
name: CTP(4-)
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
boundary condition: false
type: Species
is: HMDB00082
initial concentration: 1.0
is: CHEBI:37563
constant: false
is: SBO:0000247
initial amount: NaN

metaM citr L m
boundary condition: false
name: L-citrulline
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00904
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
constant: false
has only substance units: false
is: CHEBI:16349

metaR CO2tm
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
product: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
name: CO2 transport (diffusion), mitochondrial

metaM 4hexdtetcoa m
name: 4,7,10,13-hexadecatetraenoylcoa
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
boundary condition: false
is: HMDB02288

metaM retinol 9 cis c
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 9-cis-retinol
type: Species
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
is: CHEBI:17336
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB06217

metaR r2509
type: Reaction
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110052#
name: Utilized transport
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110052#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110052#_8c38dcab_80cc_4713_ba47_652c32ed91b2
type: Species
is: P07864
constant: false
initial concentration: NaN
is encoded by: hsa:3948
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: LDHC

http://identifiers.org/biomodels.db/MODEL1310110052#_15d4f01a_4705_4fd3_ba3a_3ff766f9e8e4
type: Species
is: O95427
name: PIGN
is encoded by: hsa:23556
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM gm3 hs g
initial amount: NaN
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
initial concentration: 1.0
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
type: Species
is: CHEBI:60065

metaR r2389
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
reversible: false
is: SBO:0000185
modifier: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
fast: false

metaR GALASE16ly
reactant: MODEL1310110052#
type: Reaction
reversible: false
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR EX ptdca LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentadecanoate exchange
type: Reaction

metaM lnlncg e
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:32391
initial concentration: 1.0
name: gamma-linolenate
is: HMDB03073
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
constant: false

metaM bilirub r
constant: false
is: SBO:0000247
is: CHEBI:57977
name: bilirubin(2-)
is: HMDB00054
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
type: Species
has only substance units: false
initial amount: NaN

metaR SERALANaEx
type: Reaction
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
is: SBO:0000185
fast: false
is described by: ECO:0000269
name: L-alanine/L-serine Na-dependent exchange (Ser-L in)
modifier: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_b08e411b_88ed_4d0b_ae72_e0070089b5f8
has only substance units: false
constant: false
name: DYLX2
is encoded by: hsa:9856
initial concentration: NaN
is: SBO:0000252
type: Species
is: F5H123
initial amount: NaN
boundary condition: true

metaR CYSO
reactant: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
product: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.20
reversible: false
is: SBO:0000176
name: cysteine oxidase
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110052#_bc421a94_4068_4107_adf2_3acb3b9de2bb
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:6487
initial concentration: NaN
type: Species
boundary condition: true
name: ST3GAL3
is: Q11203
has only substance units: false

metaR C226COAtx
reversible: true
product: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
fast: false
kinetic law: MODEL1310110052#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110052#_7b4c6ef0_6fe8_4cc9_99e4_e5c1566ff45f
initial concentration: NaN
name: _LOC374569_1_e
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:LOC374569
initial amount: NaN
type: Species
has only substance units: false

metaM ahcys m
has only substance units: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
initial amount: NaN
is: SBO:0000247
is: C00021
is: HMDB00939
name: S-Adenosyl-L-homocysteine
constant: false
is: CHEBI:16680
boundary condition: false
type: Species
initial concentration: 1.0

metaR EX tdcrn
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for myristoyl carnitine
type: Reaction

metaR 34HPPOR
is described by: ECO:0000269
modifier: MODEL1310110052#
fast: false
product: MODEL1310110052#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.27
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
type: Reaction
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: false
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:

metaM 5mta c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: 5-Methylthioadenosine
constant: false
is: HMDB01173
initial amount: NaN
is: C00170
is: CHEBI:17509
has only substance units: false
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170

metaR XYLUR
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
name: xylulose reductase
is version of: http://identifiers.org/ec-code/1.1.1.10
fast: false
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
reversible: true

metaR r2388
reactant: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000185
fast: false
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110052#
reversible: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR 2HBO
kinetic law: MODEL1310110052#
is described by: ECO:0000269
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
is: SBO:0000176
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
modifier: MODEL1310110052#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.27
reactant: MODEL1310110052#
type: Reaction
product: MODEL1310110052#

metaM c10dc x
notes: FORMULA: C17H30NO6 CHARGE: -1
boundary condition: false
type: Species
is: HMDB00651
initial concentration: 1.0
constant: false
name: sebacoyl carnitine
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM CE1944 c
has only substance units: false
name: 1-pyrrolinium
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
is: CHEBI:36781
is: SBO:0000247
type: Species

metaM HC00591 m
is: CHEBI:16769
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
constant: false
name: 2-oxoglutaramate
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110052#_ac7bdc86_4f65_462b_968d_dba439c31d2e
type: Species
name: ACP1
is encoded by: hsa:52
boundary condition: true
is: B5MCC7
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_15a96044_9907_477b_b85d_3a248d8739ee
type: Species
is encoded by: hsa:6515
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
name: SLC2A3
is: P11169
has only substance units: false

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaM ctp n
type: Species
is: HMDB00082
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:37563
has only substance units: false
name: CTP(4-)

metaM lnlncg c
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
name: gamma-linolenate
is: CHEBI:32391
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: HMDB03073

metaR FAOXC10C10OHm
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->OHC10)m
type: Reaction

metaR SO4tl
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
fast: false
is: SBO:0000185
name: Sulfate transport (lysosome)
reversible: true
product: MODEL1310110052#
is described by: ECO:0000269
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#

metaR r2387
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110052#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110052#
reactant: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110052#_51142639_d777_4dce_90c5_ceff6b29cc24
name: GNE
initial amount: NaN
is encoded by: hsa:10020
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: B7Z428
is: SBO:0000252
boundary condition: true

metaM tetdece1crn c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
constant: false
is: HMDB02014
initial amount: NaN
name: tetradecenoyl carnitine
notes: FORMULA: C21H39NO4 CHARGE: 0

metaR r2386
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110052#
is: SBO:0000185
reactant: MODEL1310110052#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
modifier: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
is described by: ECO:0000000

metaM HC00250 e
type: Species
name: hydrosulfide
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:29919
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283

metaR CYTK11
reversible: true
fast: false
product: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
name: cytidylate kinase (dCMP,dGTP)
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR GALASE19ly
modifier: MODEL1310110052#
fast: false
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110052#
name: beta-galactosidase, lysosomal
is described by: ECO:0000269
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaM o2s m
constant: false
has only substance units: false
name: Superoxide anion
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
type: Species
boundary condition: false
is: HMDB02168
is: SBO:0000247
is: C00704
is: CHEBI:18421
initial amount: NaN
initial concentration: 1.0

metaR r2506
kinetic law: MODEL1310110052#
is: SBO:0000185
product: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
fast: false
reactant: MODEL1310110052#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110052#_0acf3538_92c7_4fef_80d9_337c182d6b6f
is encoded by: hsa:8818
name: DPM2
boundary condition: true
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR MTHFCm
is: SBO:0000176
fast: false
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
is described by: ECO:0000269
modifier: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.3.4.3
reactant: MODEL1310110052#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.9
kinetic law: MODEL1310110052#

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_d81dbf33_06a9_46e4_a507_d29a56762627
is: SBO:0000252
constant: false
name: SORD
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6652
type: Species
initial amount: NaN
is: Q00796
has only substance units: false

metaR r2385
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110052#
is: SBO:0000185
modifier: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110052#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR ADRNCRNt
type: Reaction
fast: false
name: transport into the mitochondria (carnitine)
reversible: false
modifier: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) or (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#

metaR CYTK10
reactant: MODEL1310110052#
name: cytidylate kinase (CMP,dGTP)
modifier: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110052#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
type: Reaction
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_8cbf11e7_0bd4_46e3_b22e_9d3d59a9ff46
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:374291
name: NDUFS7
has only substance units: false
is: O75251
constant: false

metaM didp c
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
name: dIDP
initial concentration: 1.0
is: HMDB03536
type: Species
is: CHEBI:28823
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247

metaR FAOXC16080m
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110052#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reversible: false

metaM o2s n
is: SBO:0000247
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
name: superoxide
is: HMDB02168
constant: false
is: CHEBI:18421
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN

metaM mmcoa S m
initial concentration: 1.0
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
name: (S)-methylmalonyl-CoA(5-)
boundary condition: false
is: CHEBI:57327
initial amount: NaN
constant: false
type: Species
is: HMDB02310
is: SBO:0000247
has only substance units: false

metaM g3p c
initial concentration: 1.0
is: HMDB01112
constant: false
type: Species
is: C00661
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
boundary condition: false
is: SBO:0000247
is: CHEBI:58027
name: Glyceraldehyde 3-phosphate
has only substance units: false
is: http://identifiers.org/pubchem.compound/3930
initial amount: NaN

metaM tetdece1crn e
notes: FORMULA: C21H39NO4 CHARGE: 0
name: tetradecenoyl carnitine
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: HMDB02014
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_3dd0f871_c47f_4941_b08f_8b0cf0af224a
is: B3KQ63
boundary condition: true
is encoded by: hsa:3242
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
name: HPD

http://identifiers.org/biomodels.db/MODEL1310110052#_aeb50d46_342f_417b_b528_d346fe42d976
has part: Q6IB54
boundary condition: true
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:522
type: Species
has only substance units: false

metaR r2384
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110052#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
reactant: MODEL1310110052#
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false

metaM HC00250 c
has only substance units: false
is: CHEBI:29919
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
type: Species
name: hydrosulfide
initial amount: NaN

metaR HOCTDACBP
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyoctadecenoylcoa from mitochondria into the cytosol
type: Reaction

metaR CYTK13
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
reversible: true
fast: false
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
product: MODEL1310110052#
name: cytidylate kinase (dCMP,dATP)
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110052#_479e583e_9963_4208_9806_0e3c4cb1c83e
constant: false
initial amount: NaN
name: PDE6H
has only substance units: false
boundary condition: true
is: Q13956
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5149
type: Species

metaR CRNtim
kinetic law: MODEL1310110052#
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110052#
name: L-carnitine transport out of mitochondria via diffusion
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110052#
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_e9576e05_f302_44e9_a8d7_a322db534eb2
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: PDE8A
is encoded by: hsa:5151
constant: false
type: Species
initial amount: NaN

metaR r2508
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110052#
product: MODEL1310110052#
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110052#
fast: false
type: Reaction

metaR DESAT24 1
reversible: false
reactant: MODEL1310110052#
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
name: fatty acyl-CoA desaturase (n-C24:5CoA -> n-C24:6CoA)
is described by: ECO:0000269
product: MODEL1310110052#
is: SBO:0000176

metaM HC01602 c
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
initial concentration: 1.0
name: 10-Formyltetrahydrofolate
is: CHEBI:57454
is: C00234
type: Species
initial amount: NaN

metaR M16NTg
is: SBO:0000176
reversible: false
is described by: ECO:0000000
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
kinetic law: MODEL1310110052#
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
type: Reaction
fast: false
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.143
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_8e86a81b_55a8_4bd7_b24b_30fb18966b47
name: SLC25A22
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: Q9H936
constant: false
is encoded by: hsa:79751
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_d4696ed7_c8ad_4ccb_9f87_1390a0e4e94f
constant: false
is: SBO:0000252
is encoded by: hsa:4538
boundary condition: true
has only substance units: false
initial concentration: NaN
name: ND4
type: Species
initial amount: NaN
is: P03905

metaR UMPK3n
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110052#
name: UMP kinase (UTP),nuclear
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_2e8c716f_c549_4834_a8e5_acf52384cae0
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: O14521
constant: false
boundary condition: true
name: SDHD
is: SBO:0000252
is encoded by: hsa:6392

metaR CO2tp
reactant: MODEL1310110052#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110052#
name: CO2 peroxisomal transport
product: MODEL1310110052#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction

metaR CYTK12
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
name: cytidylate kinase (dCMP,dCTP)
type: Reaction
kinetic law: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110052#

metaR EX 3thexddcoacrn
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy trans7,10-hexadecadienoyl carnitine
type: Reaction

metaR F1PGT
type: Reaction
modifier: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.30
kinetic law: MODEL1310110052#
fast: false
product: MODEL1310110052#
reversible: true
name: fucose-1-phosphate guanylyltransferase
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD

metaR EX 3hexdcrn
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_00a38612_c6e7_422c_bfd7_8c00ff6c9d66
is encoded by: hsa:2678
name: GGT1
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P19440
constant: false

metaR XYLTt
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
name: Xylitol transport via passive diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
reactant: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
kinetic law: MODEL1310110052#

metaR r2507
kinetic law: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
name: Utilized transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110052#
fast: false
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110052#_a09d0dd6_84a2_426a_90ec_db5506aa97ef
initial concentration: NaN
initial amount: NaN
name: _AA629629_1_m
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:AA629629
has only substance units: false

metaR r1552
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: true
type: Reaction
kinetic law: MODEL1310110052#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaR ACOAD10m
reversible: false
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
kinetic law: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
fast: false
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
reactant: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
is described by: ECO:0000269

metaR C8DCc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberylcarnitine
type: Reaction

metaR MMSAD1m
name: methylmalonate-semialdehyde dehydrogenase
modifier: MODEL1310110052#
fast: false
is: SBO:0000176
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
product: MODEL1310110052#
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.2.1.27
is described by: ECO:0000269
kinetic law: MODEL1310110052#

metaR r0638
reactant: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.8.1.2
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
kinetic law: MODEL1310110052#
fast: false
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_f7d3e28c_ce02_4074_a0be_6cb0e72a6cb5
type: Species
is: SBO:0000252
is: Q16842
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6483
boundary condition: true
name: ST3GAL2
has only substance units: false
constant: false

metaR r0743
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110052#
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
product: MODEL1310110052#
fast: false

metaR GDPtg
fast: false
type: Reaction
product: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
is described by: ECO:0000000
reactant: MODEL1310110052#
is: SBO:0000185
name: GDP intracellular transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110052#_314eac35_58ce_4532_8b99_753dd52d2cd0
is: SBO:0000252
type: Species
is: P53396
is encoded by: hsa:47
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: ACLY
constant: false

metaM gchola c
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:58235
name: glycocholate
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00138

metaM 3dpdhb m
constant: false
type: Species
is: CHEBI:50775
boundary condition: false
has only substance units: false
name: 3-Decaprenyl-4,5-dihdydroxybenzoate
notes: FORMULA: C57H85O4 CHARGE: -1 INCHI: InChI=1S/C57H86O4/c1-43(2)21-12-22-44(3)23-13-24-45(4)25-14-26-46(5)27-15-28-47(6)29-16-30-48(7)31-17-32-49(8)33-18-34-50(9)35-19-36-51(10)37-20-38-52(11)39-40-53-41-54(57(60)61)42-55(58)56(53)59/h21,23,25,27,29,31,33,35,37,39,41-42,58-59H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,60,61)/b44-23+,45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_4e204ec3_1054_42ab_b955_f9ba3781925a
is: O00400
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: SLC33A1
type: Species
has only substance units: false
is encoded by: hsa:9197
constant: false
is: SBO:0000252

metaR r1551
product: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110052#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110052#

metaR PROSTGD2t
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reactant: MODEL1310110052#
name: prostaglandin transport via bicarbonate countertransport
reversible: true
modifier: MODEL1310110052#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110052#
is: SBO:0000185
kinetic law: MODEL1310110052#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_3cb5361b_641b_4352_8159_9d826d8f63ac
constant: false
is: E2QC23
is: SBO:0000252
type: Species
name: GCAT
initial concentration: NaN
is encoded by: hsa:23464
has only substance units: false
initial amount: NaN
boundary condition: true

metaR S6T2g
product: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
reactant: MODEL1310110052#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110052#

metaM dmpp x
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57623
is: HMDB01120
has only substance units: false
constant: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
name: prenyl diphosphate(3-)
is: SBO:0000247

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

metaR G16MT L
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reversible: false
name: Glycolipid 1,6-alpha-D-mannosyltransferase (liver)
is described by: ECO:0000000
product: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
fast: false

metaR r0639
is: SBO:0000176
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110052#
reversible: false
product: MODEL1310110052#
reactant: MODEL1310110052#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_5e5d2c91_831c_4e8c_80bd_84d43a96106c
initial concentration: NaN
boundary condition: true
name: AMY1B
constant: false
is encoded by: hsa:277
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: P04745

metaM ksi deg1 e
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate I, degradation product 1
is: HMDB00211
constant: false
is: CHEBI:17268
boundary condition: false
has only substance units: false

metaR D LACt2
modifier: MODEL1310110052#
is described by: ECO:0000269
name: D-lactate transport via proton symport
type: Reaction
kinetic law: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
reversible: true
is: SBO:0000185
reactant: MODEL1310110052#
fast: false

metaM dutp m
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: CHEBI:17625
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: dUTP
is: HMDB01191

metaR PDE1
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
is: SBO:0000176
reversible: false
fast: false
name: 3',5'-cyclic-nucleotide phosphodiesterase
type: Reaction
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.4.35
product: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.4.17
is described by: ECO:0000269

metaR r0744
product: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110052#
reversible: false
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
is described by: ECO:0000000

metaR r0021
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176
product: MODEL1310110052#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
reversible: true
reactant: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
fast: false

metaM itaccoa m
initial concentration: 1.0
name: itaconyl-CoA(5-)
type: Species
is: CHEBI:57381
constant: false
initial amount: NaN
is: HMDB03377
has only substance units: false
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
is: SBO:0000247
boundary condition: false

metaM udpglcur r
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: C00167
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: UDP-D-glucuronate
is: CHEBI:58052
type: Species
is: HMDB00935
constant: false

metaR SIAT9g
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: false
modifier: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
type: Reaction
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.99.9
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus

metaR r0022
fast: false
kinetic law: MODEL1310110052#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110052#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.7
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
type: Reaction
product: MODEL1310110052#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_b5488c62_ff73_42be_8166_e4f4dd79912f
boundary condition: true
is: O00217
type: Species
initial amount: NaN
is encoded by: hsa:4728
is: SBO:0000252
has only substance units: false
constant: false
name: NDUFS8
initial concentration: NaN

metaR ACACt2m
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110052#
reversible: true
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
product: MODEL1310110052#
is: SBO:0000185
modifier: MODEL1310110052#
fast: false
name: Acetoacetate mitochondrial transport via H+ symport

http://identifiers.org/biomodels.db/MODEL1310110052#_acffa982_1f1d_4e3b_b2f4_50a758de9450
is: SBO:0000297
is encoded by: hsa:5277
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
type: Species
is encoded by: hsa:8818
boundary condition: true
has part: P37287

http://identifiers.org/biomodels.db/MODEL1310110052#_b85ac243_5f48_4c97_a104_a7dee07f3c87
initial concentration: NaN
is: SBO:0000252
is: Q6IBA0
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:4725
name: NDUFS5
has only substance units: false
constant: false

metaR MTHFDm
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reversible: true
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.3
reactant: MODEL1310110052#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.9
modifier: MODEL1310110052#

metaR GUACYC
modifier: MODEL1310110052#
name: guanylate cyclase
product: MODEL1310110052#
type: Reaction
reversible: false
is described by: ECO:0000269
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/4.6.1.2
notes: GENE_ASSOCIATION: (2977.1 and 2983.1) or (4882.2) or (2982.1 and 2974.1) or (2986.1) or (4882.1) or (2984.1) or (4881.1) or (2977.1 and 2974.1) or (3000.1) or (2982.1 and 2983.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.2 Confidence Level: 4 AUTHORS: PMID:10449911,PMID:10777682,PMID:11565546,PMID:11851379,PMID:1352257,PMID:14748740,PMID:15371450,PMID:7601467,PMID:7761400,PMID:7777544,PMID:7954658,PMID:8838319,PMID:9097965,PMID:9742212 NOTES:IT
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#

metaR r1978
type: Reaction
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is: SBO:0000185
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
fast: false
reactant: MODEL1310110052#
reversible: false
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110052#_4f272c06_ca8d_4559_9a2c_1cd12992d293
constant: false
name: ACP5
initial concentration: NaN
is encoded by: hsa:54
boundary condition: true
is: P13686
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN

metaM hdcecrn m
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00222
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
type: Species
initial concentration: 1.0
is: SBO:0000247
name: Hexadecenoyl carnitine
has only substance units: false

metaM dutp n
name: dUTP
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17625
is: SBO:0000247
is: HMDB01191
boundary condition: false
has only substance units: false
constant: false

metaR PDE4
is described by: ECO:0000269
kinetic law: MODEL1310110052#
product: MODEL1310110052#
name: 3',5'-cyclic-nucleotide phosphodiesterase
is version of: http://identifiers.org/ec-code/3.1.4.35
fast: false
reversible: false
is: SBO:0000176
modifier: MODEL1310110052#
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.4.17
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD
type: Reaction

metaR EX c8crn
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_2edae8ef_2e14_4376_ae90_dbfbe00df93e
has only substance units: false
is encoded by: hsa:10400
name: PEMT
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN

metaM adrncrn m
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:16347
name: Adrenyl carnitine
has only substance units: false
initial concentration: 1.0
type: Species
is: C00318
notes: FORMULA: C29H49NO4 CHARGE: 0
is: SBO:0000247
is: HMDB00062

http://identifiers.org/biomodels.db/MODEL1310110052#_3bc9c6b3_6225_4856_a29a_4da7298b6a2f
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:AL038231
type: Species
initial amount: NaN
name: _AL038231_1_c
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_c3dcf811_ec88_4aa6_8300_a944181fba99
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:124
initial concentration: NaN
initial amount: NaN
constant: false
is: P07327
name: ADH1A

http://identifiers.org/biomodels.db/MODEL1310110052#_08176662_5ff0_40d2_b3c8_808d1a944e1f
name: SKIV2L2
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q3MHC9
is encoded by: hsa:23517
initial concentration: NaN
type: Species
has only substance units: false

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaR FAS160COA
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
fast: false
modifier: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110052#
name: fatty-acyl-CoA synthase (n-C16:0CoA)
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110052#_84678170_3e1d_464e_9545_061d2f0ff47d
has only substance units: false
boundary condition: true
name: INPP5D
initial amount: NaN
type: Species
is: Q92835
initial concentration: NaN
is encoded by: hsa:3635
constant: false
is: SBO:0000252

metaM lnlncgcrn c
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
name: gamma-linolenyl carnitine
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1
is: HMDB06318
type: Species
has only substance units: false

metaR CHLtm
product: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110052#
name: choline transport via diffusion (cytosol to mitochondria)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
type: Reaction
fast: false
is: SBO:0000185

metaM c101coa c
is: HMDB00651
name: decenoylcoa
is: SBO:0000247
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false

metaM phe L e
is: HMDB00159
is: SBO:0000247
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:17295
name: L-phenylalanine
boundary condition: false

metaR EX hpdca LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptadecanoate exchange
type: Reaction

metaR ACACT1x
modifier: MODEL1310110052#
reversible: false
fast: false
product: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
is described by: ECO:0000134
reactant: MODEL1310110052#
name: acetyl-CoA C-acetyltransferase, mitochondrial
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9

http://identifiers.org/biomodels.db/MODEL1310110052#_f6ec7624_7a56_4519_80a3_61b8ac6aa17c
initial amount: NaN
initial concentration: NaN
name: BCAT1
boundary condition: true
is encoded by: hsa:586
constant: false
is: P54687
has only substance units: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_ff32dde6_587e_4ce3_aae1_e605f06de3d9
boundary condition: true
initial amount: NaN
is: P49327
is: SBO:0000252
constant: false
is encoded by: hsa:2194
has only substance units: false
name: FASN
initial concentration: NaN
type: Species

metaM maltttr e
is: C02052
boundary condition: false
initial amount: NaN
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
is: SBO:0000247
type: Species
is: HMDB01296
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/5141
name: Maltotetraose
initial concentration: 1.0

metaM tddedi2coa m
name: trans2,6dodecadienoylcoa
is: HMDB00792
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
has only substance units: false
is: C08277
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species

metaR MEVK1x
reversible: false
is: SBO:0000176
reactant: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.1.36 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version NJ
is version of: http://identifiers.org/ec-code/2.7.1.36
is described by: ECO:0000134
name: mevalonate kinase (atp)
fast: false
modifier: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_aa0dde2e_c4e9_4690_8e14_3efcd31029c7
constant: false
name: GGT5
initial amount: NaN
boundary condition: true
is: P36269
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:2687
has only substance units: false

metaM bilirub c
boundary condition: false
is: CHEBI:57977
name: bilirubin(2-)
constant: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: SBO:0000247
is: HMDB00054
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species

metaR F6Tg
name: glycoprotein 6-alpha-L-fucosyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.68
fast: false
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: false
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_fb5153a3_1ef0_4a70_a132_227601a78165
initial amount: NaN
type: Species
name: CTPS1
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:1503
has only substance units: false
is: P17812

metaR ACACT1r
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110052#
name: acetyl-CoA C-acetyltransferase
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.9
product: MODEL1310110052#

metaM xyl D e
name: aldehydo-D-xylose
is: CHEBI:15936
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_0de58862_f891_4dff_aabc_e28033771ca9
initial concentration: NaN
is: P35475
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
constant: false
name: IDUA
has only substance units: false
is encoded by: hsa:3425

http://identifiers.org/biomodels.db/MODEL1310110052#_58605380_8a20_4460_811e_0d221a69ef71
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AV727634
has only substance units: false
is: SBO:0000252
name: _AV727634_1_c
initial amount: NaN
constant: false

metaM hom L e
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00719
type: Species
name: L-homoserine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial amount: NaN
is: SBO:0000247
is: CHEBI:15699
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_9775b58a_f0d5_46a8_9caa_c273013394d4
is encoded by: hsa:1956
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P00533
type: Species
initial concentration: NaN
name: EGFR
boundary condition: true

metaM o2s e
initial concentration: 1.0
is: CHEBI:18421
name: superoxide
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB02168
constant: false
type: Species
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial amount: NaN

metaM phe L c
boundary condition: false
type: Species
is: CHEBI:17295
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00159
is: SBO:0000247
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
name: L-phenylalanine
initial amount: NaN

metaR FAS100COA
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110052#
product: MODEL1310110052#
modifier: MODEL1310110052#
is: SBO:0000176
name: fatty acyl-CoA synthase (n-C10:0CoA)
is described by: ECO:0000269
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reversible: false
reactant: MODEL1310110052#

metaM nrpphr c
initial concentration: 1.0
is: CHEBI:33569
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00216
name: Norepinephrine
initial amount: NaN
boundary condition: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
type: Species

metaR SEBACIDTD
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacic acid into cytosol (diffusion)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_5fa01244_b205_41cf_98e0_319ee7d80794
boundary condition: true
initial amount: NaN
constant: false
name: NANS
type: Species
is: SBO:0000252
is encoded by: hsa:54187
initial concentration: NaN
has only substance units: false
is: Q9NR45

http://identifiers.org/biomodels.db/MODEL1310110052#_0d9fc59a_fdb5_4501_b117_0404d7d5441b
name: PLCL1
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5334
is: Q15111

metaR ETOHt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110052#
reactant: MODEL1310110052#
name: ethanol reversible transport
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110052#
type: Reaction

metaR r2379
product: MODEL1310110052#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110052#

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_74609129_fec0_496e_99c3_4383e0b0455a
boundary condition: true
has only substance units: false
name: HGD
is: Q93099
constant: false
is encoded by: hsa:3081
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_8077ad80_bb0d_41e5_950d_f250af780d52
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: NMNAT3
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:349565
is: Q96T66
constant: false

metaR r1401
is version of: http://identifiers.org/ec-code/3.2.1.35
is version of: http://identifiers.org/ec-code/2.3.1.51
is version of: http://identifiers.org/ec-code/2.7.10.1
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
reversible: false
name: Facilitated diffusion
type: Reaction
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.1.3
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.41
reactant: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_56e897d0_a7ed_44a3_82cb_80c0dfcf084f
initial amount: NaN
name: CA1
is encoded by: hsa:759
is: SBO:0000252
is: P00915
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_0d1a5a74_6ffe_4717_9808_08761c87e4fa
name: SULT1A3
type: Species
initial amount: NaN
is: Q1ET61
constant: false
is encoded by: hsa:6818
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR RE1519M
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.13
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#
is: SBO:0000176
modifier: MODEL1310110052#
type: Reaction
name: RE1519
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110052#_4d1c3abe_4e74_48c5_bc44_96b317f56596
is: C9JPQ8
name: PCCA
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5095
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species

metaR PTDCACRNCPT2
fast: false
modifier: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
name: pentadecanoate transport into the mitochondria
reversible: false
is: SBO:0000176
reactant: MODEL1310110052#

metaR r0741
is described by: ECO:0000000
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110052#
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
reversible: true
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m
product: MODEL1310110052#
is: SBO:0000176
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_683d3bbb_8def_44c5_9d60_bd6346fcae3e
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q8N3T1
is encoded by: hsa:117248
constant: false
is: SBO:0000252
name: GALNTL2
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_6aaa351b_a9aa_406e_ad04_1d77f5d3cd15
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: HAS3
is: O00219
is encoded by: hsa:3038
type: Species
has only substance units: false
constant: false

metaM ksii core4 pre4 g
has only substance units: false
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 4
type: Species
is: SBO:0000247
is: HMDB00175
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:58053
is: C00130
notes: FORMULA: C61H99N5O43X CHARGE: -1

metaR C180CPT1
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110052#
name: production of stearoylcarnitine
fast: false
reversible: false
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (1375.4) or (1375.2) or (126129.1) or (1375.1) or (1374.1) or (1375.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TV (see C160CRN)
type: Reaction
is: SBO:0000176

metaR OCTDECCPT2
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaM bilirub e
has only substance units: false
is: CHEBI:57977
boundary condition: false
constant: false
name: bilirubin(2-)
is: SBO:0000247
is: HMDB00054
initial amount: NaN
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_b4b57bb7_c9a5_406b_af19_545b2a14a672
has only substance units: false
name: _R14373_1_x
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:R14373
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_b902a424_8554_4031_a7ac_82117cfed970
is: SBO:0000252
is: P21912
initial amount: NaN
boundary condition: true
name: SDHB
is encoded by: hsa:6390
has only substance units: false
initial concentration: NaN
constant: false
type: Species

metaR r0027
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.39
modifier: MODEL1310110052#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
reversible: true
product: MODEL1310110052#
fast: false
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_7eac18ea_26cb_4fa4_89ed_0f20165c8473
initial concentration: NaN
name: SLC12A6
is: Q9UHW9
has only substance units: false
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:9990
initial amount: NaN

metaM zymstnl r
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
name: 5alpha-cholest-8-en-3beta-ol
is: SBO:0000247
is: HMDB06841
is: CHEBI:16608

metaR PTDCACRNCPT1
notes: GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
modifier: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
reversible: false
is described by: ECO:0000269
name: carnitine fatty-acyl transferase
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110052#
is: SBO:0000176
fast: false

metaM hom L c
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
name: L-homoserine
is: HMDB00719
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:15699

metaM CE5101 m
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
constant: false
is: CHEBI:57795
boundary condition: false
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR CAROtr
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000185
name: beta-carotene transport via diffusion
kinetic law: MODEL1310110052#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110052#_499b5636_d9fd_4aad_8de8_da3c4eb20bbc
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
name: UGP2
initial amount: NaN
is encoded by: hsa:7360

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaR C180CPT2
reversible: false
product: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
kinetic law: MODEL1310110052#
name: carnitine O-stearoyl transferase
type: Reaction
is: SBO:0000176
reactant: MODEL1310110052#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR FAOXC221C201x
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_c37536ec_e0d7_4a68_8737_652fbdbefe72
type: Species
initial concentration: NaN
is encoded by: hsa:10380
initial amount: NaN
name: BPNT1
is: O95861
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_41ff5f0d_f2ab_4831_af6b_eaa5d79d52c7
boundary condition: true
is encoded by: hsa:211
has only substance units: false
initial concentration: NaN
name: ALAS1
is: P13196
is: SBO:0000252
initial amount: NaN
constant: false
type: Species

metaM trdrd c
type: Species
is: CHEBI:15967
name: Reduced thioredoxin
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: C00342

metaM ksi deg1 l
is: SBO:0000247
type: Species
initial concentration: 1.0
name: keratan sulfate I, degradation product 1
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
is: CHEBI:18287
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: HMDB00174

metaR r1154
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
product: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#
name: EC:1.2.7.2
reactant: MODEL1310110052#
type: Reaction
reversible: true
fast: false

metaR C161CRN2t
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
modifier: MODEL1310110052#
name: C161 transport into the mitochondria
is described by: ECO:0000269
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110052#
is: SBO:0000185

metaR r0630
is version of: http://identifiers.org/ec-code/3.1.3.1
is: SBO:0000176
type: Reaction
reactant: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.2
modifier: MODEL1310110052#
reversible: true
kinetic law: MODEL1310110052#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
product: MODEL1310110052#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_882cce52_633f_46aa_a877_19627267f417
initial amount: NaN
name: GALNT13
is: Q8IUC8
has only substance units: false
boundary condition: true
is encoded by: hsa:114805
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species

metaR HEXCOAACBP
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexanoyl-CoA (n-C6:0CoA) from mitochondria into cytosol
type: Reaction

metaM 3octdece1coa c
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB13336
name: 3-hydroxyoctadecenoylcoa
initial concentration: 1.0
has only substance units: false
constant: false
type: Species

metaM prpp e
boundary condition: false
is: HMDB00280
has only substance units: false
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
constant: false
initial concentration: 1.0
is: CHEBI:58017
initial amount: NaN
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_1dffec96_77e0_456c_a63b_9b4fef249e65
initial concentration: NaN
constant: false
is encoded by: hsa:28231
name: SLCO4A1
initial amount: NaN
is: Q96BD0
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR G14T2g
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is: SBO:0000176
fast: false
modifier: MODEL1310110052#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110052#

metaM dutp c
name: dUTP
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: HMDB01191
has only substance units: false
is: CHEBI:17625
is: C00460
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_ad0d7649_e599_46ce_8a16_b934b4b392d8
has only substance units: false
type: Species
name: AMACR
is: Q3KT79
is encoded by: hsa:23600
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_7f968edd_a222_49e3_aad1_598cd0c1943f
name: GCK
is encoded by: hsa:2645
constant: false
initial amount: NaN
is: P35557
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species

metaR OCTDECCPT1
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaM ksi deg24 l
is: HMDB00143
name: keratan sulfate I, degradation product 24
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
is: CHEBI:12936
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
constant: false

metaM Rtotal3coa c
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: CHEBI:16189
initial concentration: 1.0
name: R total 3 Coenzyme A
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
boundary condition: false
initial amount: NaN
is: HMDB01448

metaM ksii core2 deg8 l
initial concentration: 1.0
notes: FORMULA: C36H60N3O25X CHARGE: 0
is: SBO:0000247
is: CHEBI:12936
name: keratan sulfate II (core 2-linked), degradation product 8
has only substance units: false
constant: false
type: Species
is: HMDB00143
boundary condition: false
initial amount: NaN

metaM HC01496 m
is: SBO:0000247
is: CHEBI:28095
initial concentration: 1.0
name: 2-Amino-3-oxoadipate
boundary condition: false
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
initial amount: NaN
constant: false
type: Species
has only substance units: false

metaR T4HCINNMFM
fast: false
is: SBO:0000176
reversible: false
name: 4-hydroxycinnamate formation
kinetic law: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
reactant: MODEL1310110052#
type: Reaction
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_b577e127_0920_48f5_b1a3_03c3ca0274c6
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:5277
name: PIGA
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR r1559
is described by: ECO:0000000
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110052#
reversible: true

metaM hdcecrn c
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
name: Hexadecenoyl carnitine
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00222
constant: false
type: Species
has only substance units: false
initial concentration: 1.0

metaR KSItly
name: keratan sulfate I transport, extracellular to lysosome
reversible: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110052#
is described by: ECO:0000000
fast: false

metaM s2l2fn2m2masn e
notes: FORMULA: C90H145N6O65X CHARGE: -2
constant: false
boundary condition: false
initial amount: NaN
name: PA6
is: CHEBI:3554
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
is: C00255
is: HMDB00244

metaM 3decdicoa m
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
name: 3,7-decadienoylcoa
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_306f6e33_942e_4b16_be2d_7b25edbd0334
is encoded by: hsa:10948
name: STARD3
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is: B4DUY1
constant: false
has only substance units: false
initial concentration: NaN

metaR RPI
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/5.3.1.6
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
name: ribose-5-phosphate isomerase
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
reactant: MODEL1310110052#
modifier: MODEL1310110052#
is: SBO:0000176
product: MODEL1310110052#

metaM 5fthf m
type: Species
name: 5-formyltetrahydrofolate(2-)
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57457
is: SBO:0000247
constant: false
is: HMDB01562
boundary condition: false

metaR SERASNNaEx
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-serine/L-asparagine Na-dependent exchange (Ser-L in)
fast: false
product: MODEL1310110052#
is described by: ECO:0000269
reactant: MODEL1310110052#
type: Reaction
is: SBO:0000185
reversible: false

metaR VD3
fast: false
type: Reaction
name: Vitamin D3 formation
reactant: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT

metaR r1156
kinetic law: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
is: SBO:0000176
product: MODEL1310110052#

metaR STRDNCCRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110052#
type: Reaction
name: transport into the mitochondria (carnitine)
fast: false
reactant: MODEL1310110052#
modifier: MODEL1310110052#
is: SBO:0000185
kinetic law: MODEL1310110052#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110052#_e69af9a5_70e9_427a_8bda_598ab7e32bf7
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:622
name: BDH1
initial concentration: NaN
boundary condition: true

metaR 3AIBt
type: Reaction
is: SBO:0000185
name: 3-amino-isobutyrate transport
reactant: MODEL1310110052#
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:HOW? IT
product: MODEL1310110052#

metaM btamp c
constant: false
initial concentration: 1.0
is: CHEBI:3110
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
has only substance units: false
is: SBO:0000247
name: Biotinyl-5'-AMP
is: HMDB04220

metaM prpp c
is: CHEBI:58017
is: HMDB00280
constant: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: 5-Phospho-alpha-D-ribose 1-diphosphate
is: C00119

metaR DUTPDPn
is version of: http://identifiers.org/ec-code/3.6.1.23
kinetic law: MODEL1310110052#
fast: false
name: dUTP diphosphatase, nuclear
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
reversible: false
reactant: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110052#
is described by: ECO:0000269

metaR CRNt
reversible: true
reactant: MODEL1310110052#
is described by: ECO:0000269
fast: false
is: SBO:0000185
product: MODEL1310110052#
name: L-carnitine reversible transport
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#

metaM o2s c
is: HMDB02168
constant: false
has only substance units: false
type: Species
boundary condition: false
name: superoxide
initial amount: NaN
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18421

metaM gmp c
is: HMDB01397
initial concentration: 1.0
constant: false
name: GMP
is: C00144
initial amount: NaN
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: SBO:0000247
is: CHEBI:58115
type: Species
has only substance units: false
boundary condition: false

metaM ksi deg3 l
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
type: Species
is: CHEBI:30825
initial concentration: 1.0
is: HMDB00573
initial amount: NaN
name: keratan sulfate I, degradation product 3

metaR NACDe
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

metaM 3dhguln c
name: 3-dehydro-L-gulonate
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:57655
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
is: HMDB06334
initial concentration: 1.0
type: Species

metaR r0633
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
product: MODEL1310110052#
reversible: true
modifier: MODEL1310110052#
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.7.3
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:

metaR r1557
kinetic law: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110052#
reactant: MODEL1310110052#

metaR LEULEULAPc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Leucylleucine in the small intestine for cellular uptake
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_df28a978_8a5f_4931_b126_2938783ec576
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:5052
initial concentration: NaN
name: PRDX1
constant: false
type: Species

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR EX 1glyc hs LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1 acyl phosphoglycerol exchange
type: Reaction

metaR DUTPDPm
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
reversible: false
reactant: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000269
name: dUTP diphosphatase
is version of: http://identifiers.org/ec-code/3.6.1.23
kinetic law: MODEL1310110052#

metaM o2 x
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: C00007
is: HMDB01377
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
name: O2
type: Species
constant: false
is: CHEBI:15379

metaR r0634
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.1
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
kinetic law: MODEL1310110052#
is described by: ECO:0000000
reversible: true
fast: false
modifier: MODEL1310110052#
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
product: MODEL1310110052#
reactant: MODEL1310110052#

metaM xyl D l
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:15936
name: aldehydo-D-xylose

metaR ALAASNNaEx
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
reactant: MODEL1310110052#
reversible: false
is described by: ECO:0000269
product: MODEL1310110052#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
fast: false
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)

metaR r1150
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
name: Facilitated diffusion
fast: false
is described by: ECO:0000000
product: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
is: SBO:0000185
type: Reaction
reversible: false

metaR r0747
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
reactant: MODEL1310110052#
fast: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000176
type: Reaction

metaM dsmsterol r
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
type: Species
has only substance units: false
initial amount: NaN
name: desmosterol
boundary condition: false
is: HMDB02719
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:17737

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaM orot e
initial amount: NaN
constant: false
is: HMDB00226
type: Species
is: SBO:0000247
has only substance units: false
name: orotate
initial concentration: 1.0
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: CHEBI:30839
boundary condition: false

metaM 6thf e
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
name: hexaglutamyl folate (THF)
constant: false
is: SBO:0000247
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/169691

metaR r1556
product: MODEL1310110052#
reversible: true
kinetic law: MODEL1310110052#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110052#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaM HC00591 c
initial amount: NaN
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
name: 2-oxoglutaramate
type: Species
constant: false
is: CHEBI:16769
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM gmp e
name: GMP(3-)
is: HMDB01397
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:58115
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_1b6d7c4e_bbc8_446e_a4e6_6aeca56b20f7
constant: false
is: O75356
initial amount: NaN
name: ENTPD5
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:957
type: Species
boundary condition: true

metaR RE1691M
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.8.1.1
type: Reaction
fast: false
name: RE1691
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
is: SBO:0000176
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110052#
product: MODEL1310110052#

metaR HACD1m
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
fast: false
kinetic law: MODEL1310110052#
product: MODEL1310110052#
modifier: MODEL1310110052#
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110052#
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110052#_54148911_6bbb_47f7_9d6d_1a4be77b8e95
constant: false
is: SBO:0000252
name: GOT1
is: P17174
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2805

metaR C4STMO2r
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.170
is described by: ECO:0000000
reactant: MODEL1310110052#
fast: false
type: Reaction
modifier: MODEL1310110052#
name: C-4 methyl sterol oxidase
is version of: http://identifiers.org/ec-code/1.14.13.72
reversible: false
product: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ

metaR DTTPtn
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#
name: dTTP diffusion in nucleus
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_bdfe06d7_ab35_4320_b1fe_d8e49278a269
is: SBO:0000252
name: NDUFB6
is: Q5VYT2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4712
constant: false
type: Species
boundary condition: true
initial amount: NaN

metaR r0178
reversible: true
product: MODEL1310110052#
reactant: MODEL1310110052#
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
fast: false
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.5.1.21
kinetic law: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaM em2emgacpail hs r
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
constant: false
is: HMDB03125
is: SBO:0000247
is: CHEBI:16240
has only substance units: false

metaM malthx e
boundary condition: false
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
name: Maltohexaose
is: http://identifiers.org/pubchem.compound/5041
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: C01936
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_38144d34_e48d_4f20_80fa_61e94d52a89b
constant: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
name: _D87002_1_e
is: SBO:0000252
has only substance units: false
is encoded by: hsa:D87002

metaR CMPSASn
is: SBO:0000176
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.43
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
is described by: ECO:0000304
reversible: false
type: Reaction
name: CMP sialic acid synthase, nuclear
modifier: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_b31a2152_bbf0_42ae_8b9a_06e05b47d252
initial amount: NaN
is: Q6IBA0
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4725
initial concentration: NaN
constant: false
type: Species
name: NDUFS5
boundary condition: true

metaR SEBCOAPET
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

metaM gchola e
has only substance units: false
notes: FORMULA: C26H43NO6 CHARGE: 0
constant: false
boundary condition: false
is: HMDB00138
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
name: glycocholate

metaR RPE
fast: false
reactant: MODEL1310110052#
name: ribulose 5-phosphate 3-epimerase
is version of: http://identifiers.org/ec-code/5.1.3.1
product: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110052#
reversible: true
modifier: MODEL1310110052#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP

metaR FAOXC15ATPx
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C15)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_b9faf783_2bd8_4e9a_906f_ce6689170fc7
is encoded by: hsa:51102
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
name: MECR
has only substance units: false
is: Q9BV79
boundary condition: true
is: SBO:0000252

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaR GTHP
reactant: MODEL1310110052#
modifier: MODEL1310110052#
reversible: true
name: glutathione peroxidase
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.11.1.15
is version of: http://identifiers.org/ec-code/1.11.1.12
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
kinetic law: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.9

metaM 3snpyr m
constant: false
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
name: 3-Sulfinopyruvate
is: CHEBI:1665
has only substance units: false
is: HMDB02332
boundary condition: false

metaR UPPN
name: b-ureidopropionase
fast: false
reactant: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.6

metaR r0179
is version of: http://identifiers.org/ec-code/1.1.1.27
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
product: MODEL1310110052#
reactant: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
reversible: true

metaR r1554
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110052#
reversible: true
type: Reaction
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#

metaM gmp g
is: SBO:0000247
name: GMP(3-)
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
has only substance units: false
is: CHEBI:58115
boundary condition: false
type: Species
is: HMDB01397

metaR ANTIPYRENEte
name: xenobiotic transport
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
kinetic law: MODEL1310110052#
is: SBO:0000185
reversible: true
reactant: MODEL1310110052#

metaR RE1448N
product: MODEL1310110052#
kinetic law: MODEL1310110052#
name: RE1448
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
is: SBO:0000176
reversible: true

metaR OXAtp
fast: false
product: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
kinetic law: MODEL1310110052#
is: SBO:0000185
reversible: false
name: oxalate transport out of peroxisome

metaM ksi deg6 l
type: Species
boundary condition: false
name: keratan sulfate I, degradation product 6
is: SBO:0000247
is: HMDB00143
is: CHEBI:12936
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_4198a294_c09f_40c9_a05b_5d5eb81561b8
name: ACSL5
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:51703
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: Q9ULC5

metaR r1553
is: SBO:0000185
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110052#
reversible: true
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110052#_90ea78ab_f12f_4c64_b648_dcb4fafc41fb
constant: false
type: Species
name: ACSL3
is encoded by: hsa:2181
is: SBO:0000252
boundary condition: true
has only substance units: false
is: O95573
initial amount: NaN
initial concentration: NaN

metaR NH4t3r
fast: false
kinetic law: MODEL1310110052#
reversible: true
name: ammonia transport via proton antiport
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
modifier: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
is: SBO:0000185
product: MODEL1310110052#
is described by: ECO:0000269

metaR AG13T9g
is described by: ECO:0000000
reactant: MODEL1310110052#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
type: Reaction
kinetic law: MODEL1310110052#
is: SBO:0000176
product: MODEL1310110052#
reversible: false
modifier: MODEL1310110052#

metaR CHOLtn
kinetic law: MODEL1310110052#
is: SBO:0000185
reactant: MODEL1310110052#
reversible: true
fast: false
is described by: ECO:0000000
name: Choline transport, nuclear through pores
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
type: Reaction

metaM 3octdece1coa m
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280355
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
name: 3-hydroxyoctadecenoylcoa
constant: false
is: SBO:0000247

metaM lac D e
type: Species
initial concentration: 1.0
name: (R)-lactate
constant: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
initial amount: NaN
boundary condition: false
is: HMDB01311
is: SBO:0000247
is: CHEBI:16004
has only substance units: false

metaM lnlnca e
is: HMDB01388
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: alpha-linolenate
boundary condition: false
is: CHEBI:32387
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_c0862926_c039_4325_979c_996219c6decb
is encoded by: hsa:766
name: CA7
constant: false
is: P43166
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM orot c
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00226
initial amount: NaN
is: CHEBI:30839
constant: false
is: C00295
is: SBO:0000247
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
name: Orotate

metaM dgdp c
is: HMDB00960
is: SBO:0000247
name: dGDP
initial amount: NaN
is: CHEBI:58595
has only substance units: false
is: C00361
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
type: Species
constant: false

metaM retinal c
has only substance units: false
boundary condition: false
is: HMDB01358
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
constant: false
name: retinal
is: CHEBI:15035

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

metaM dtmp e
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:26999
name: dTMP(2-)
is: HMDB01227
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0

metaM accoa x
is: SBO:0000247
type: Species
is: C00024
boundary condition: false
constant: false
is: HMDB01206
has only substance units: false
initial amount: NaN
name: Acetyl-CoA
is: CHEBI:57288
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial concentration: 1.0

metaM tmndnc e
initial amount: NaN
has only substance units: false
boundary condition: false
name: timnodonic acid C20:5, n-3
constant: false
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/446284
initial concentration: 1.0
is: HMDB01999
type: Species

metaR GLCMter
reactant: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11882499 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000
reversible: false
fast: false
type: Reaction
name: glucose transport via membrane vesicle

http://identifiers.org/biomodels.db/MODEL1310110052#_8c896ab5_0035_40a5_921a_f9ee50b7ceef
initial amount: NaN
has only substance units: false
is encoded by: hsa:AA854479
constant: false
initial concentration: NaN
name: _AA854479_1_m
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_ef45d3f1_43b3_472d_8398_76d5fc325ff5
initial amount: NaN
constant: false
name: GLRX2
is: Q9NS18
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:51022
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_f97c071e_44c0_4be9_afab_610ad341772b
name: SLC7A1
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P30825
is: SBO:0000252
type: Species
is encoded by: hsa:6541

http://identifiers.org/biomodels.db/MODEL1310110052#_2f58960a_465d_4c82_9dc2_788225212fb6
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: O95167
name: NDUFA3
type: Species
is: SBO:0000252
is encoded by: hsa:4696
boundary condition: true

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

metaM o2 r
initial concentration: 1.0
is: HMDB01377
is: C00007
is: CHEBI:15379
has only substance units: false
boundary condition: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: SBO:0000247
name: O2

http://identifiers.org/biomodels.db/MODEL1310110052#_6d9fe855_3832_40f8_b235_21f02c48fb51
type: Species
constant: false
initial amount: NaN
name: UPP1
boundary condition: true
has only substance units: false
is encoded by: hsa:7378
is: SBO:0000252
is: Q16831
initial concentration: NaN

metaM gluala e
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
is: C03740
is: http://identifiers.org/pubchem.compound/6503
name: 5-L-Glutamyl-L-alanine
type: Species
boundary condition: false
constant: false
is: HMDB06248
is: SBO:0000247

metaR LEUKTRF4t
name: leukotriene F4 transport
kinetic law: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true

metaR AKGMALtm
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
kinetic law: MODEL1310110052#
name: alpha-ketoglutarate/malate transporter
modifier: MODEL1310110052#
is: SBO:0000185
fast: false
reactant: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110052#_532f0c00_df76_4403_98f4_26adc0105143
name: CROT
boundary condition: true
initial concentration: NaN
is: E7EQF2
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:54677
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_b5da208c_ffa1_43b4_a515_38e30723c8a6
constant: false
initial amount: NaN
is: F6SH78
name: ELOVL5
initial concentration: NaN
boundary condition: true
is encoded by: hsa:60481
type: Species
is: SBO:0000252
has only substance units: false

metaR r1116
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
product: MODEL1310110052#
is: SBO:0000185
fast: false
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
reversible: true
type: Reaction
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000

metaR RE3524R
is: SBO:0000176
name: RE3524
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
product: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#

metaR FBA2
product: MODEL1310110052#
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
reversible: true
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/4.1.2.13
reactant: MODEL1310110052#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110052#
is described by: ECO:0000304

metaR MANter
product: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
name: mannose efflux from endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110052#_da4ed5b9_6296_44a7_b77a_3ef94b357875
initial concentration: NaN
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
is: SBO:0000297
has part: Q6FIH7
boundary condition: true
type: Species
constant: false
is encoded by: hsa:516
initial amount: NaN

metaR PRISTtx
is: SBO:0000185
kinetic law: MODEL1310110052#
name: prist peroxisomal transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
type: Reaction
reactant: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000000
fast: false

metaM 2mb2coa c
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
name: 2-methylcrotonoyl-CoA(4-)
has only substance units: false
is: HMDB02054

metaR ASCBt
name: L-ascorbate transport via facilitated diffusion
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
fast: false
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#

metaM btamp m
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:3110
is: HMDB04220
type: Species
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
name: Biotinyl-5'-AMP
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110052#_bf275e64_8f6c_4c50_af9f_88655bc0d5d2
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8309
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: Q99424
name: ACOX2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_0f9bbaac_5cae_498a_b7ae_d3899bf4942f
has only substance units: false
is encoded by: hsa:220
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
name: ALDH1A3
is: P47895
constant: false
boundary condition: true

metaR PSSA1 hs
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
reversible: true
modifier: MODEL1310110052#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110052#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.29
name: Phosphatidylserine synthase homo sapiens
product: MODEL1310110052#
kinetic law: MODEL1310110052#

metaM tmndnc c
type: Species
has only substance units: false
is: HMDB01999
name: timnodonic acid C20:5, n-3
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/446284

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaR ADPCOAPTE
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of adipoyl coA for release into cytosol
type: Reaction

metaR GACPAILter
is: SBO:0000185
name: glucosaminyl-acylphosphatidylinositol ER flippase
reversible: false
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
is described by: ECO:0000000
fast: false

metaM 3mop e
has only substance units: false
is: HMDB00491
boundary condition: false
initial amount: NaN
name: 3-methyl-2-oxopentanoate
initial concentration: 1.0
is: CHEBI:28654
is: SBO:0000247
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_d6528eb9_a7e2_408d_872d_746422beeb1d
type: Species
initial concentration: NaN
is encoded by: hsa:9061
constant: false
has only substance units: false
name: PAPSS1
initial amount: NaN
boundary condition: true
is: O43252
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_24cee212_2fbe_4a49_8ef5_a3dd9482330b
initial concentration: NaN
name: NDUFV2
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:4729
constant: false
is: P19404

metaR THRD L
is version of: http://identifiers.org/ec-code/4.3.1.17
is: SBO:0000176
name: L-threonine deaminase
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 4.3.1.19 Confidence Level: 4 AUTHORS: PMID:12361482 NOTES:Previous EC number: 4.2.1.16. New EC number 4.3.1.19. Can't enter this....
is described by: ECO:0000269
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110052#

metaR ELAIDCRNt
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110052#
type: Reaction
modifier: MODEL1310110052#
fast: false
is: SBO:0000185
product: MODEL1310110052#
kinetic law: MODEL1310110052#

metaM tridcoa m
is: HMDB13109
type: Species
initial amount: NaN
constant: false
boundary condition: false
name: tridecanoylcoa
is: SBO:0000247
notes: FORMULA: C34H56N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0

metaR r0196
product: MODEL1310110052#
fast: false
modifier: MODEL1310110052#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
reactant: MODEL1310110052#
is described by: ECO:0000000

metaR MEOHt2
type: Reaction
kinetic law: MODEL1310110052#
name: Methanol diffusion
is: SBO:0000185
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_e4ac0f11_cbe0_4425_b44d_72e8a496d12a
is encoded by: hsa:3990
initial concentration: NaN
boundary condition: true
is: A6H8L5
constant: false
is: SBO:0000252
has only substance units: false
name: LIPC
initial amount: NaN
type: Species

metaM 3mob c
has only substance units: false
is: CHEBI:11851
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00019
name: 3-methyl-2-oxobutanoate
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_cb2f83de_ec70_4282_8300_0d1c40f2254b
name: SLC35D1
constant: false
is: Q9NTN3
type: Species
is encoded by: hsa:23169
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false

metaM ac e
boundary condition: false
initial amount: NaN
is: HMDB00042
is: CHEBI:30089
is: SBO:0000247
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
name: acetate

http://identifiers.org/biomodels.db/MODEL1310110052#_afaa5153_1d06_45f6_931c_aa554c426db3
name: OAT
type: Species
is: P04181
has only substance units: false
is encoded by: hsa:4942
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false

metaR r0480
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
type: Reaction
reversible: true
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
fast: false
reactant: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#
is described by: ECO:0000000

metaM o2 m
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: CHEBI:15379
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: C00007

http://identifiers.org/biomodels.db/MODEL1310110052#_5b93e4da_aea2_4c9e_ab70_4adf7f7f9ffe
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: A6NFM2
has only substance units: false
name: PYCR1
constant: false
is encoded by: hsa:5831
type: Species
initial amount: NaN

metaM arachd c
has only substance units: false
name: arachidonate
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:32395
is: SBO:0000247
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
is: HMDB01043

metaR C18OHc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecanoylcarnitine
type: Reaction

metaR ACt2m
fast: false
name: acetate mitochondrial transport via proton symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#
product: MODEL1310110052#

metaR FAOXC164C143m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_f4dfcf65_f787_4ada_b9ae_99a02eceb4a4
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
name: COX1
initial concentration: NaN
is encoded by: hsa:4512
is: Q7GXY8
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_6a79832b_9e13_4bfc_b44d_6b162078c544
type: Species
is: A8K3L7
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:10423
has only substance units: false
name: CDIPT

metaM thbpt4acam n
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:15374
is: HMDB02281
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
type: Species
name: 4a-hydroxytetrahydrobiopterin

http://identifiers.org/biomodels.db/MODEL1310110052#_c343ea4f_938f_48bc_9e23_26e5eb5b7266
is encoded by: hsa:279
boundary condition: true
constant: false
is: P04746
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: AMY2A

http://identifiers.org/biomodels.db/MODEL1310110052#_7047f1ce_76d3_44cc_b263_2aa99ae04d11
initial amount: NaN
type: Species
is encoded by: hsa:18
name: ABAT
is: SBO:0000252
is: P80404
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR SO4OXAtex2
is described by: ECO:0000304
is: SBO:0000185
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reactant: MODEL1310110052#
name: sulfate transport via oxalate countertransport (2:1)
product: MODEL1310110052#
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
reversible: false
type: Reaction

metaM akg x
constant: false
initial amount: NaN
name: 2-oxoglutarate(2-)
is: HMDB00208
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:16810
boundary condition: false

metaR RE2541E
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
reversible: true
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.31
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
name: RE2541
modifier: MODEL1310110052#
is described by: ECO:0000000
type: Reaction

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaM andrstandn r
is: CHEBI:15994
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: 5alpha-androstane-3,17-dione
type: Species
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
has only substance units: false
is: HMDB00899
initial amount: NaN

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

metaR HDECEACBP
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecenoylcoa from mitochondria into the cytosol
type: Reaction

metaR ORNLEUrBATtc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Ornithine into the cell in exchange for L-Leucine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

metaM o2 n
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
constant: false
name: dioxygen
type: Species
is: HMDB01377
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:15379
initial concentration: 1.0
initial amount: NaN

metaM 3mop c
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
is: HMDB00491
name: 3-methyl-2-oxopentanoate
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28654
type: Species
has only substance units: false

metaR r0483
reversible: true
kinetic law: MODEL1310110052#
is: SBO:0000176
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
is described by: ECO:0000000
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
reactant: MODEL1310110052#
fast: false
type: Reaction

metaM g6p r
initial concentration: 1.0
boundary condition: false
type: Species
name: D-Glucose 6-phosphate
initial amount: NaN
is: HMDB01401
is: CHEBI:61548
is: C00092
constant: false
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_ba3aaba0_639e_4451_943c_a20a4927d0e4
has only substance units: false
is: O00443
type: Species
is: SBO:0000252
is encoded by: hsa:5286
initial concentration: NaN
name: PIK3C2A
initial amount: NaN
constant: false
boundary condition: true

MODEL1310110052
reaction: metaR SPRMS
reaction: metaR FAOXC16C14m
reaction: metaR r0962
reaction: metaR CRVNCtr
species: metaM Rtotalcoa c
reaction: metaR GGT6
species: metaM arachcrn c
reaction: metaR HSD3A1r
species: metaM c8crn e
reaction: metaR CGLYt3 2
species: metaM dcsptn1coa c
species: metaM lpchol hs e
species: metaM sphs1p e
reaction: metaR MGSA2
species: metaM acnam c
reaction: metaR sink tetdece1coa LPAREN c RPAREN
reaction: metaR MG2er
reaction: metaR r2125
species: metaM hcys L c
reaction: metaR r2331
reaction: metaR r0549
reaction: metaR FACOAL1813
reaction: metaR r0474
reaction: metaR r0755
reaction: metaR r0680
reaction: metaR CYSO
species: metaM nac c
reaction: metaR EX antipyrene LPAREN e RPAREN
reaction: metaR r1876
reaction: metaR r2516
reaction: metaR ALAASNNaEx
reaction: metaR r1648
species: metaM icit c
species: metaM met L c
reaction: metaR r2009
reaction: metaR PIPLC
reaction: metaR r1797
reaction: metaR HSD3A2r
reaction: metaR CYTK13
reaction: metaR EX CE5786 LPAREN e RPAREN
reaction: metaR CAROtr
reaction: metaR r0267
reaction: metaR S6T7g
species: metaM 3hmp m
species: metaM 5adtststerone c
reaction: metaR SIAT9g
reaction: metaR CYSGLNNaEx
reaction: metaR FAOXC15ATPx
species: metaM amp c
reaction: metaR r2372
species: metaM succ x
reaction: metaR PSFLIPm
reaction: metaR EX arab L LPAREN e RPAREN
species: metaM adrncoa m
reaction: metaR G12MT1 L
species: metaM taur x
reaction: metaR CSPG Etly
species: metaM asp L m
reaction: metaR EX btn LPAREN e RPAREN
species: metaM prostgi2 e
reaction: metaR EX lnlnca LPAREN e RPAREN
reaction: metaR r2120
species: metaM coucoa m
reaction: metaR AMPtp
species: metaM phyt x
species: metaM glyb m
reaction: metaR HPACtr
species: metaM ribflv c
reaction: metaR CTPtn
reaction: metaR r0801
reaction: metaR MI145PK
reaction: metaR COQ7m
reaction: metaR DHFtm
reaction: metaR UPPN
reaction: metaR r1660
reaction: metaR r0750
reaction: metaR ALADGLNexR
species: metaM ru5p D r
reaction: metaR C142OHe
species: metaM lnlncg e

metaM cyan m
has only substance units: false
is: CHEBI:18407
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
constant: false
initial amount: NaN
boundary condition: false
name: hydrogen cyanide
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB02084

metaM lnlc e
is: CHEBI:30245
name: linoleate
initial concentration: 1.0
constant: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00673
type: Species
is: SBO:0000247

metaM ac c
type: Species
is: SBO:0000247
is: HMDB00042
initial amount: NaN
is: CHEBI:30089
constant: false
name: acetate
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033

metaM lnlnca c
initial concentration: 1.0
is: HMDB01388
is: CHEBI:32387
is: SBO:0000247
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
name: alpha-linolenate

metaM tyr L m
is: SBO:0000247
type: Species
is: CHEBI:17895
initial amount: NaN
name: L-tyrosine
boundary condition: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
constant: false
has only substance units: false
is: HMDB00158
initial concentration: 1.0

metaM m2mpdol L c
is: CHEBI:28049
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C1420H2328N20O320P20 CHARGE: -20
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110052#_0e0a6e54_1120_4801_954f_5bd0d21cee7f
initial concentration: NaN
name: SLC13A2
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:9058
type: Species
initial amount: NaN
is: E7ETH5

http://identifiers.org/biomodels.db/MODEL1310110052#_389b9c13_2cb8_4119_ab41_4fdbf692a23c
type: Species
is: Q1LZ56
name: SLC36A1
boundary condition: true
initial concentration: NaN
is encoded by: hsa:206358
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false

metaR CDPDAGtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: intracellular transport
fast: false
reactant: MODEL1310110052#
reversible: true

metaM 4hphac e
is: CHEBI:48999
type: Species
constant: false
is: HMDB00020
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: 4-hydroxyphenylacetate
initial amount: NaN
is: SBO:0000247

metaR LNELDCCRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
fast: false
reversible: false
name: transport into the mitochondria (carnitine)
product: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000185

metaR r0193
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
fast: false
reactant: MODEL1310110052#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110052#
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
type: Reaction
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_7969ea6c_8829_43d2_9449_768ec7fb7325
initial amount: NaN
is: P30043
initial concentration: NaN
has only substance units: false
is encoded by: hsa:645
constant: false
boundary condition: true
is: SBO:0000252
type: Species
name: BLVRB

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaR CSPG Atly
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
product: MODEL1310110052#
name: chondroitin sulfate A transport, extracellular to lysosome
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_90b1ef8f_7e34_4c5c_92f4_94e72182719c
initial amount: NaN
boundary condition: true
is: Q96NR8
type: Species
has only substance units: false
is encoded by: hsa:145226
initial concentration: NaN
is: SBO:0000252
constant: false
name: RDH12

http://identifiers.org/biomodels.db/MODEL1310110052#_cbb42632_5686_4070_a73d_4a446cc118ac
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AW277253
name: _AW277253_1_c
is: SBO:0000252

metaM dolmanp L r
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
has only substance units: false
type: Species
is: CHEBI:15809
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: Dolichyl phosphate D-mannose, human liver homolog
constant: false

metaM pydx c
initial concentration: 1.0
initial amount: NaN
constant: false
name: Pyridoxal
is: HMDB01545
boundary condition: false
type: Species
has only substance units: false
is: C00250
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
is: SBO:0000247
is: CHEBI:17310

http://identifiers.org/biomodels.db/MODEL1310110052#_0056e47d_13cb_4578_9923_de7226f262f8
name: HSD17B4
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: E9PB82
is encoded by: hsa:3295

metaR ACt2r
kinetic law: MODEL1310110052#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110052#
is described by: ECO:0000000
fast: false
name: acetate reversible transport via proton symport
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
reversible: true

metaR r0590
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
kinetic law: MODEL1310110052#
is: SBO:0000176
fast: false
modifier: MODEL1310110052#
product: MODEL1310110052#
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110052#_b51c5b90_b841_47fb_8032_169f4dfd6deb
type: Species
is: SBO:0000252
is encoded by: hsa:3291
initial concentration: NaN
has only substance units: false
is: P80365
name: HSD11B2
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_5976332a_2905_4544_8da9_0a71860c581f
initial concentration: NaN
boundary condition: true
is encoded by: hsa:412
name: STS
has only substance units: false
type: Species
is: SBO:0000252
is: P08842
constant: false
initial amount: NaN

metaR 34DHXMANDACOX NADP
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110052#
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
is: SBO:0000176
product: MODEL1310110052#
fast: false
type: Reaction
reactant: MODEL1310110052#
is described by: ECO:0000269
kinetic law: MODEL1310110052#
reversible: true

metaM xyl D c
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:15936
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
name: aldehydo-D-xylose
is: SBO:0000247
initial amount: NaN
type: Species
constant: false

metaR r0191
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.24
fast: false
kinetic law: MODEL1310110052#
reversible: false
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
is: SBO:0000176
type: Reaction
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110052#_a428b719_f882_445a_9a86_1338ca106e4f
boundary condition: true
name: GALE
is: Q38G75
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:2582
initial amount: NaN
has only substance units: false

metaM HC02207 c
is: CHEBI:27555
constant: false
boundary condition: false
name: prostaglandin-c2
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_e9a659cf_9c37_4b2a_8fae_a3516beb557f
constant: false
has only substance units: false
name: GALNT14
initial concentration: NaN
is encoded by: hsa:79623
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is: Q96FL9

http://identifiers.org/biomodels.db/MODEL1310110052#_7060404e_b67b_4c80_be0d_b1450ee82a0d
boundary condition: true
is encoded by: hsa:AI971036
has only substance units: false
is: SBO:0000252
name: _AI971036_1_c
initial amount: NaN
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_d8911f6c_b425_4e26_8143_30f58d41d1e8
is encoded by: hsa:2712
constant: false
name: GK2
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q14410

metaM udpgal g
is: HMDB00302
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: UDP-D-galactose(2-)
is: CHEBI:58439
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
boundary condition: false
initial concentration: 1.0

metaM hexde7coa x
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
constant: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
name: 7-hexadecenoylcoa
is: HMDB02288

metaR ARACHDtr
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
name: intracellular transport
fast: false
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_61e1361b_2a99_4347_80db_65e685fca7d6
is: P11310
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:34
name: ACADM
constant: false

metaR GLYCLTtp
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110052#
name: glycolate transport into peroxisome
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110052#
reversible: false

metaR SUCCACT
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of succinate
type: Reaction

metaM lnlc c
initial amount: NaN
type: Species
name: linoleate
is: HMDB00673
constant: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: CHEBI:30245
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM gal c
initial amount: NaN
is: CHEBI:0
type: Species
is: HMDB00143
boundary condition: false
name: D-Galactose
constant: false
is: C00124
notes: FORMULA: C6H12O6 CHARGE: 0
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR MAGt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:10344773 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110052#
name: monoacylglycerol 2 transport
kinetic law: MODEL1310110052#
fast: false
reversible: true
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_4b73df1e_8c0f_4306_b9d4_e7473f7eef6e
constant: false
is encoded by: hsa:4846
initial amount: NaN
is: SBO:0000252
type: Species
is: A0S0A7
name: NOS3
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR 34HPPte
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
name: Transport of 3-(4-hydroxyphenyl)pyruvate
reversible: true
is: SBO:0000185
reactant: MODEL1310110052#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110052#_27eafa14_30b7_4f63_9833_bac74d718654
constant: false
name: PIGV
is: Q9NUD9
type: Species
initial amount: NaN
is encoded by: hsa:55650
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR TAURt4 2 r
reactant: MODEL1310110052#
type: Reaction
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110052#
fast: false
name: taurine transport (sodium symport) (2:1)
is described by: ECO:0000269
kinetic law: MODEL1310110052#
reversible: true
is: SBO:0000185

metaR ACETONEt2m
name: acetone mitochondrial transport via proton symport
reactant: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
fast: false
product: MODEL1310110052#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110052#_a297acff_d48a_489b_8169_1221a1b93c9b
is: SBO:0000297
initial concentration: NaN
constant: false
has part: O00330
is encoded by: hsa:8050
has part: P09622
is encoded by: hsa:1738
initial amount: NaN
has only substance units: false
has part: P36957
type: Species
has part: Q02218
boundary condition: true
is encoded by: hsa:1743
name: DLD:DLST:OGDH:PDHX
is encoded by: hsa:4967

metaR ENGASE2ly
is described by: ECO:0000000
is: SBO:0000176
name: endo-beta-N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110052#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_dc281930_97a1_46fb_809a_1f710e1ae4cc
name: ALDH1A3
constant: false
is encoded by: hsa:220
is: P47895
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false

metaR EX oagd3 hs LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-O-Acetylated GD3 (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_f92005ef_da9b_4590_aaf7_04a7a2978809
initial amount: NaN
boundary condition: true
type: Species
name: ACSS3
has only substance units: false
constant: false
is: SBO:0000252
is: Q9H6R3
initial concentration: NaN
is encoded by: hsa:79611

metaR r1418
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is: SBO:0000176
reversible: true
reactant: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110052#

metaM 5pmev x
is: HMDB01343
is: CHEBI:58146
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00670 EHMN_ABBREVIATION: C01107
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
name: (R)-5-phosphonatomevalonate(3-)
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_be947dcd_c27b_4de6_8f0d_ee4cfc5e53fc
name: DAD1
is: Q53G02
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:1603
type: Species
initial concentration: NaN

metaR CHOLtu
reversible: true
name: Choline uniport
reactant: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
is: SBO:0000185
fast: false
kinetic law: MODEL1310110052#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110052#

metaM adrncrn c
is: CHEBI:16347
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C29H49NO4 CHARGE: 0
initial amount: NaN
type: Species
is: C00318
is: HMDB00062
name: Adrenyl carnitine

metaR UMPK4n
is: SBO:0000176
kinetic law: MODEL1310110052#
name: UMP kinase (GTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110052#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110052#
type: Reaction
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_85cba21f_2192_4a16_b1be_38da2e79ceb9
initial concentration: NaN
is: Q01433
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species
name: AMPD2
is encoded by: hsa:271
is: SBO:0000252

metaM HC02207 e
is: CHEBI:27555
constant: false
is: SBO:0000247
boundary condition: false
name: prostaglandin-c2
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955

http://identifiers.org/biomodels.db/MODEL1310110052#_e4473f16_9c48_4d17_b1c4_114f0ce4cfa0
name: NDUFB6
is encoded by: hsa:4712
type: Species
boundary condition: true
constant: false
is: O95139
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_08862347_476f_4718_8bc3_d76a40fcdde2
is: P36969
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
name: GPX4
is encoded by: hsa:2879

http://identifiers.org/biomodels.db/MODEL1310110052#_df5da957_d61f_470d_a758_72260989354e
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
name: BLVRA
has only substance units: false
type: Species
is encoded by: hsa:644
is: P53004
initial amount: NaN

metaM arachd e
boundary condition: false
has only substance units: false
is: CHEBI:32395
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
is: HMDB01043
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
name: arachidonate

metaM 3mob e
is: HMDB00019
is: SBO:0000247
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
has only substance units: false
boundary condition: false
initial amount: NaN
name: 3-methyl-2-oxobutanoate
is: CHEBI:11851
initial concentration: 1.0
constant: false
type: Species

metaR r0591
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
is: SBO:0000176
reversible: true
modifier: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
kinetic law: MODEL1310110052#
fast: false
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110052#_e2419d6f_be30_41d9_bb65_22d0bd4a1818
is encoded by: hsa:203
is: SBO:0000252
boundary condition: true
has only substance units: false
name: AK1
is: P00568
initial amount: NaN
constant: false
type: Species
initial concentration: NaN

metaR CYTDK2m
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
kinetic law: MODEL1310110052#
name: cytidine kinase (ATP), mitochondrial
type: Reaction
reactant: MODEL1310110052#
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110052#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110052#_6f61ee4e_9702_497b_b744_624436cc7d86
is encoded by: hsa:57194
initial concentration: NaN
name: ATP10A
is: SBO:0000252
has only substance units: false
is: O60312
initial amount: NaN
constant: false
type: Species
boundary condition: true

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR HEDCECRNe
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecenoyl carnitine into extra cellular space
type: Reaction

metaM hdd2coa x
is: SBO:0000247
type: Species
is: HMDB03945
constant: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
initial amount: NaN
is: CHEBI:61526
name: (E)-hexadec-2-enoyl-CoA(4-)
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR r0594
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000176
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
reversible: true
fast: false

metaR SERHL
fast: false
is described by: ECO:0000269
modifier: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:2674117 NOTES:MM
name: L-Serine hydro-lyase
reactant: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#
reversible: false
is version of: http://identifiers.org/ec-code/4.3.1.17

metaM dcholcoa c
boundary condition: false
name: chenodeoxycholoyl coenzyme a
is: CHEBI:28701
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB06292
is: SBO:0000247
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337

http://identifiers.org/biomodels.db/MODEL1310110052#_14326488_24d8_4569_b30e_42e4c14f76ae
initial concentration: NaN
is encoded by: hsa:4245
is: P26572
is: SBO:0000252
type: Species
has only substance units: false
constant: false
name: MGAT1
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_6da8bea5_f902_46dd_b37c_b70a654bb392
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:MBOAT5
type: Species
has only substance units: false
constant: false
boundary condition: true
name: _MBOAT5_1_c

http://identifiers.org/biomodels.db/MODEL1310110052#_a2d4d08b_1e61_4102_a93b_612c79f87242
is: SBO:0000252
has only substance units: false
is: P22680
constant: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: CYP7A1
is encoded by: hsa:1581

metaR RE2973C
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
name: RE2973
is version of: http://identifiers.org/ec-code/2.7.1.137
is described by: ECO:0000000
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.1.153
is: SBO:0000176
reactant: MODEL1310110052#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.154
type: Reaction
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
is version of: http://identifiers.org/ec-code/2.7.11.1

metaM 3mop m
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
initial amount: NaN
is: CHEBI:28654
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: HMDB00491
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671

http://identifiers.org/biomodels.db/MODEL1310110052#_79f66b6e_2962_413b_b595_70e78db5e38e
is: Q8NFF5
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:80308
boundary condition: true
has only substance units: false
name: FLAD1
is: SBO:0000252

metaR PROSTGE2t2
is: SBO:0000185
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
type: Reaction
reactant: MODEL1310110052#
is described by: ECO:0000269
product: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
name: prostaglandin uniport
kinetic law: MODEL1310110052#
reversible: true

metaR CBASPte
is described by: ECO:0000134
is: SBO:0000185
type: Reaction
name: Transport of N-carbamoyl-L-aspartate
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: true
fast: false

metaR S6T1g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction

metaR r1117
name: Facilitated diffusion
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: true
type: Reaction
fast: false

metaR sink tetdec2coa LPAREN c RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDEC2COASINK
type: Reaction

metaR P45027A1m
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
reversible: false
kinetic law: MODEL1310110052#
is described by: ECO:0000269
reactant: MODEL1310110052#
name: Cytochrome P450 27
is: SBO:0000176

metaM 3hexdcrn c
name: 3-hydroxyhexadecanoylcarnitine
notes: FORMULA: C23H45NO5 CHARGE: 0
is: HMDB13336
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110052#_103da3ec_3dec_40b7_82c0_6fddffc39c3f
has only substance units: false
boundary condition: true
is encoded by: hsa:2109
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
name: ETFB
initial amount: NaN

metaR r0488
reactant: MODEL1310110052#
fast: false
product: MODEL1310110052#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
type: Reaction
kinetic law: MODEL1310110052#
is described by: ECO:0000000
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34

metaR ASCBt4
name: L-ascorbate transport via proton symport
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#
fast: false
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
type: Reaction
is: SBO:0000185

metaM udpgal c
type: Species
has only substance units: false
constant: false
is: CHEBI:58439
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial amount: NaN
is: SBO:0000247
name: UDP-D-galactose(2-)
boundary condition: false
is: HMDB00302

http://identifiers.org/biomodels.db/MODEL1310110052#_0961a46f_0566_485c_a05e_e414a08820b9
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:6576
is: D9HTE9
has only substance units: false
initial amount: NaN
name: SLC25A1
type: Species

metaM m7mpdol L r
initial concentration: 1.0
notes: FORMULA: C1720H2828N20O570P20 CHARGE: -20
constant: false
boundary condition: false
type: Species
initial amount: NaN
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
is: CHEBI:37636
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_7fd1106a_430b_4a81_a892_7acf5a6a7684
initial amount: NaN
initial concentration: NaN
name: CPT1B
type: Species
has only substance units: false
is: E9PCP2
is encoded by: hsa:1375
boundary condition: true
is: SBO:0000252
constant: false

metaM met L c
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
initial concentration: 1.0
is: HMDB00696
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
is: CHEBI:16643
name: L-methionine

metaR G12MT2 L
product: MODEL1310110052#
reversible: false
type: Reaction
reactant: MODEL1310110052#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110052#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)

http://identifiers.org/biomodels.db/MODEL1310110052#_49b43cfd_ae10_4075_885c_a5b0acac27f4
is encoded by: hsa:AI291895
is: SBO:0000252
constant: false
name: _AI291895_1_c
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN

metaM o2 e
has only substance units: false
boundary condition: false
is: HMDB01377
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: C00007
type: Species
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
constant: false
is: CHEBI:15379

metaR AG13T14g
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
modifier: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaR IZPN
name: Imidazolonepropionase
reactant: MODEL1310110052#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110052#
is: SBO:0000176
product: MODEL1310110052#
fast: false
is described by: ECO:0000000
type: Reaction

metaM pacald c
is: SBO:0000247
type: Species
is: HMDB06236
has only substance units: false
constant: false
is: CHEBI:16424
name: phenylacetaldehyde
initial concentration: 1.0
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
boundary condition: false
initial amount: NaN

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaR GALASE12ly
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110052#
reversible: false
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110052#
product: MODEL1310110052#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_8f4b3277_d9e1_4a49_af8c_227df2c9e651
initial concentration: NaN
name: AK2
is: P54819
is encoded by: hsa:204
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_15fe7864_d85c_44a8_bda7_a73e6419575c
initial concentration: NaN
type: Species
is: P04035
is: SBO:0000252
name: HMGCR
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:3156
boundary condition: true

metaR CYTDtm
modifier: MODEL1310110052#
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction
is described by: ECO:0000269
name: cytidine facilated transport in mitochondria
fast: false
reversible: true
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
product: MODEL1310110052#
is: SBO:0000185

metaR r0596
is: SBO:0000176
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
fast: false

metaM akg m
has only substance units: false
name: 2-Oxoglutarate
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: HMDB00208
type: Species
boundary condition: false
is: CHEBI:16810
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C00026

metaR DNDPt22m
reversible: false
name: dTDP transport via dUDP antiport
modifier: MODEL1310110052#
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
product: MODEL1310110052#
kinetic law: MODEL1310110052#

metaM lneldccoa c
is: http://identifiers.org/pubchem.compound/9543677
initial amount: NaN
name: linoelaidyl coenzyme A
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
is: HMDB06521
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_0cc557e5_f326_4376_b1f6_11df3dd84c89
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: Q1EHB4
is encoded by: hsa:159963
name: SLC5A12

metaR CYTK1
type: Reaction
product: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: cytidylate kinase (CMP)
is described by: ECO:0000269
modifier: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110052#

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaM ksii core4 deg2 l
name: keratan sulfate II (core 4-linked), degradation product 2
is: SBO:0000247
is: CHEBI:12936
initial amount: NaN
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
constant: false
is: HMDB00143
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species

metaR NRPPHRSFt
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000000
reversible: false
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110052#
name: norepinephrine sulfate transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110052#_b391a42e_c625_48d2_b8ab_cd506fd83068
type: Species
is: P49914
boundary condition: true
has only substance units: false
name: MTHFS
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:10588

http://identifiers.org/biomodels.db/MODEL1310110052#_3ade067e_a54f_464e_a97c_d140d74291c0
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q15274
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:23475
initial amount: NaN
name: QPRT

http://identifiers.org/biomodels.db/MODEL1310110052#_b0c17990_2f60_419b_b494_9ac2cf123b0d
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3632
is: SBO:0000252
boundary condition: true
type: Species
name: INPP5A
is: Q14642

http://identifiers.org/biomodels.db/MODEL1310110052#_ad3c3ba1_748c_4c31_a8e9_6a3205149182
is: B4DJQ3
name: SHMT2
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:6472
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM HC01118 r
has only substance units: false
name: presqualene diphosphate(3-)
type: Species
is: SBO:0000247
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57310
constant: false

metaR r2397
reversible: false
product: MODEL1310110052#
is: SBO:0000185
reactant: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110052#

metaM dtmp c
has only substance units: false
name: dTMP
boundary condition: false
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:26999
is: C00364
is: SBO:0000247
is: HMDB01227
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364

metaM 3hexdcrn e
is: HMDB13336
notes: FORMULA: C23H45NO5 CHARGE: 0
type: Species
name: 3-hydroxyhexadecanoylcarnitine
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM CE0713 m
has only substance units: false
is: HMDB02329
boundary condition: false
is: CHEBI:30623
name: 3-oxolinoleoyl-CoA
constant: false
initial amount: NaN
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM cyan e
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB02084
name: hydrogen cyanide
is: SBO:0000247
constant: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
initial concentration: 1.0
type: Species
is: CHEBI:18407

metaR CYTK2
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110052#
is: SBO:0000176
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
reactant: MODEL1310110052#
type: Reaction
reversible: true
name: cytidylate kinase (dCMP)
fast: false

metaM met L e
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16643
is: HMDB00696
is: SBO:0000247
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
type: Species
constant: false
name: L-methionine
has only substance units: false
boundary condition: false

metaM dhap x
is: C00111
boundary condition: false
name: Dihydroxyacetone phosphate
is: HMDB01473
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:57642
is: http://identifiers.org/pubchem.compound/3411
type: Species
has only substance units: false
initial amount: NaN

metaM CE2422 m
is: SBO:0000247
is: HMDB11123
boundary condition: false
constant: false
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
is: CHEBI:28387
initial amount: NaN
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
type: Species
has only substance units: false
initial concentration: 1.0

metaR SBTD D2
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
name: D-sorbitol dehydrogenase (D-fructose producing)
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.1.14
reversible: false
notes: GENE_ASSOCIATION: (6652.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.14 Confidence Level: 0 AUTHORS: PMID:14965227 NOTES:NCD
product: MODEL1310110052#
is: SBO:0000176

metaR URIK1
modifier: MODEL1310110052#
name: uridine kinase (ATP:Uridine)
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.48
is: SBO:0000176
product: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: false
reactant: MODEL1310110052#
fast: false
is described by: ECO:0000269
type: Reaction

metaM thbpt4acam c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB02281
is: CHEBI:15374
boundary condition: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
has only substance units: false
type: Species
name: 4a-hydroxytetrahydrobiopterin
constant: false

metaR r1562
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110052#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaM cyan c
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:18407
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
name: hydrogen cyanide
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB02084

metaM hdd2coa m
name: trans-Hexadec-2-enoyl-CoA
constant: false
is: CHEBI:61526
initial concentration: 1.0
type: Species
is: HMDB03945
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: C05272

metaR CYTK4
reactant: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
name: cytidylate kinase (dCMP)(GTP)
is described by: ECO:0000269
modifier: MODEL1310110052#
type: Reaction

metaR r0733
modifier: MODEL1310110052#
reversible: false
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
type: Reaction
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.5.1.12
fast: false
is described by: ECO:0000000
reactant: MODEL1310110052#
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
kinetic law: MODEL1310110052#

metaM ctp e
boundary condition: false
is: SBO:0000247
is: CHEBI:37563
type: Species
constant: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: HMDB00082
name: CTP(4-)
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR CYSGLUexR
modifier: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110052#
name: L-cysteine/L-glutamine reversible exchanger
product: MODEL1310110052#

metaM hco3 m
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
initial amount: NaN
name: Bicarbonate
constant: false
is: HMDB00595
is: CHEBI:17544
is: C00288
type: Species
initial concentration: 1.0

metaM citr L c
initial concentration: 1.0
is: HMDB00904
constant: false
is: CHEBI:16349
boundary condition: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
name: L-citrulline

metaR RE1903R
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
reversible: true
fast: false
product: MODEL1310110052#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
name: RE1903

metaM ksi pre35 g
constant: false
is: CHEBI:28067
boundary condition: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 35
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C241H384N17O205S11X CHARGE: -12

http://identifiers.org/biomodels.db/MODEL1310110052#_a5593246_bb8f_4c88_a743_ac94fa5b6d78
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is: Q9ULD0
is encoded by: hsa:55753
initial amount: NaN
initial concentration: NaN
constant: false
name: OGDHL

metaM 2mp2coa m
initial amount: NaN
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:27754
name: 2-Methylprop-2-enoyl-CoA
boundary condition: false
has only substance units: false
is: HMDB01011

metaR CYTK3
kinetic law: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
name: cytidylate kinase (CMP)(GTP)
modifier: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000269
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: true
is: SBO:0000176

metaR ALADGLYexR
kinetic law: MODEL1310110052#
type: Reaction
fast: false
is described by: ECO:0000304
reversible: true
modifier: MODEL1310110052#
name: D-alanine/glycine reversible exchange
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110052#
reactant: MODEL1310110052#

metaR r1561
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110052#
fast: false
reversible: true
type: Reaction
product: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110052#_8c8c32f0_0963_4508_aa27_d5130bfab4f4
is: B4DZR2
initial concentration: NaN
initial amount: NaN
name: ALDH1A2
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:8854

metaR r0734
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

metaR BAAT2x
reactant: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
name: bile acid Coenzyme A: amino acid N-acyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000269
product: MODEL1310110052#
reversible: false

metaR r0629
is version of: http://identifiers.org/ec-code/3.6.1.22
product: MODEL1310110052#
reactant: MODEL1310110052#
reversible: true
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.1
fast: false
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#

metaM hdca c
boundary condition: false
is: HMDB00220
constant: false
type: Species
name: palmitate
has only substance units: false
initial amount: NaN
is: CHEBI:7896
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial concentration: 1.0
is: SBO:0000247

metaM HC01408 m
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
initial concentration: 1.0
is: CHEBI:27648
is: SBO:0000247
constant: false
has only substance units: false
name: 3-Oxohexanoyl-CoA

metaR RDH2
product: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.1.315
is: SBO:0000176
reactant: MODEL1310110052#
name: retinol dehydrogenase (9-cis,NADH)
fast: false
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT

metaR r1564
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction

metaR FAOXC10C8x
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_0287e539_8600_4174_b9ca_1b20c7eb854b
type: Species
constant: false
has only substance units: false
name: CHKB
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1120
initial concentration: NaN
is: A0PJM6

metaM ctp c
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: SBO:0000247
is: CHEBI:37563
type: Species
is: HMDB00082
is: C00063
has only substance units: false
constant: false
name: CTP
initial concentration: 1.0

metaR r0731
reversible: false
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110052#
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#

metaR CYTK6
product: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is: SBO:0000176
kinetic law: MODEL1310110052#
reversible: true
name: cytidylate kinase (CMP,CTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110052#

metaM lpam m
initial amount: NaN
constant: false
is: HMDB00962
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17460
name: lipoamide
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248

metaM acetol c
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
constant: false
name: hydroxyacetone
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:27957
has only substance units: false
is: HMDB06961
type: Species

metaM 44mctr r
has only substance units: false
is: HMDB01023
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:17813
initial concentration: 1.0
type: Species
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol

http://identifiers.org/biomodels.db/MODEL1310110052#_dba9fbed_26e7_4e70_8140_931f478176b3
initial concentration: NaN
initial amount: NaN
name: _HG2846_HT2983_1_m
constant: false
type: Species
boundary condition: true
is encoded by: hsa:HG2846-HT2983
is: SBO:0000252
has only substance units: false

metaM o2 c
is: CHEBI:15379
is: SBO:0000247
is: HMDB01377
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
has only substance units: false
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
is: C00007

http://identifiers.org/biomodels.db/MODEL1310110052#_38231c45_8b47_4742_9ec8_e93716bbb2fd
initial concentration: NaN
initial amount: NaN
name: ATP5C1
is encoded by: hsa:509
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is: P36542
boundary condition: true

metaR RDH3
fast: false
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.1.315
is: SBO:0000176
product: MODEL1310110052#
kinetic law: MODEL1310110052#
name: retinol dehydrogenase (11-cis,NADH)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
type: Reaction
reversible: true
reactant: MODEL1310110052#

metaM citr L e
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial amount: NaN
is: HMDB00904
constant: false
has only substance units: false
is: CHEBI:16349
is: SBO:0000247
name: citr_L[e]

metaM HC01609 e
has only substance units: false
constant: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
name: UroporphyrinogenI
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:28766

http://identifiers.org/biomodels.db/MODEL1310110052#_fcc56147_6bf4_4509_b675_a1c1eb93331d
has only substance units: false
initial amount: NaN
name: ATP5F1
initial concentration: NaN
is: SBO:0000252
is: P24539
type: Species
boundary condition: true
constant: false
is encoded by: hsa:515

metaR r1563
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110052#
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110052#
product: MODEL1310110052#

metaR HIVCRNe
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-isovaleryl carnitine into extra cellular space
type: Reaction

metaR r0033
type: Reaction
reversible: false
kinetic law: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
modifier: MODEL1310110052#
is described by: ECO:0000000
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110052#
fast: false
is: SBO:0000176

metaM CE4790 m
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:57923

metaM xoltetrol c
is: CHEBI:17278
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
type: Species
is: HMDB01231
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446

metaR r0732
is described by: ECO:0000000
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
product: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110052#
reversible: false

metaR RE2974C
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110052#
reversible: true
name: RE2974
is version of: http://identifiers.org/ec-code/2.7.1.68
is described by: ECO:0000000
modifier: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.149
product: MODEL1310110052#

metaR CYTK5
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
fast: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110052#
name: cytidylate kinase (dCMP)
is described by: ECO:0000269
reactant: MODEL1310110052#
is: SBO:0000176
product: MODEL1310110052#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110052#_670d4b26_991a_46ba_ad4e_69288bf70c72
type: Species
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:NM 013421
has only substance units: false
name: _NM_013421_1_e
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_d5a941d3_8da6_41ac_b044_d2f6d8e92f37
is: SBO:0000252
boundary condition: true
constant: false
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: AFMID
is encoded by: hsa:125061
is: Q63HM1

metaM dece4coa m
type: Species
boundary condition: false
is: HMDB02145
is: SBO:0000247
name: 4-decenoylcoa
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
has only substance units: false
constant: false
initial concentration: 1.0

metaR CSNAT2m
is version of: http://identifiers.org/ec-code/2.3.1.7
modifier: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
fast: false
reversible: true
name: carnitine O-aceyltransferase, mitochondrial

metaR C141OHe
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:1-OH
type: Reaction

metaR r0627
fast: false
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
reactant: MODEL1310110052#
is: SBO:0000176
type: Reaction
product: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110052#_e90f906e_9400_4f78_a9a9_fc67d8c82ae6
is: P40926
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: MDH2
boundary condition: true
is encoded by: hsa:4191
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_bb010729_6309_47db_9603_a09c6da1686e
constant: false
is encoded by: hsa:2271
boundary condition: true
is: P07954
type: Species
initial concentration: NaN
name: FH
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_bdfbdb08_332c_4809_8314_58019dc2c782
name: DPM2
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:8818
is: SBO:0000252
initial concentration: NaN
is: O94777

metaR SPRMTDe
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: Larqu? E, Sabater-Molina M, Zamora S. (2007). Nutrition 23: 87-95, PMID: 11564949. NOTES:polyamines are taken up by diffusion process, although specific carriers and para-cellular transport has also been documented.
kinetic law: MODEL1310110052#
fast: false
name: absorption for spermine across the basolateral side
is described by: ECO:0000134
reversible: true
type: Reaction
reactant: MODEL1310110052#
product: MODEL1310110052#

metaM hdca e
notes: FORMULA: C16H31O2 CHARGE: -1
name: Hexadecanoate (n-C16:0)
initial concentration: 1.0
has only substance units: false
is: HMDB00220
is: C00249
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: CHEBI:0
boundary condition: false

metaM hpdca e
boundary condition: false
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
initial amount: NaN
has only substance units: false
name: margarate
constant: false
is: CHEBI:32366
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB02259

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR TAURtcx
is described by: ECO:0000212
kinetic law: MODEL1310110052#
product: MODEL1310110052#
name: taurine transport (sodium symport) (cytosol to peroxisome)
reversible: true
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:8010975 NOTES:SAB
is: SBO:0000185
fast: false
reactant: MODEL1310110052#
type: Reaction
modifier: MODEL1310110052#

metaM h x
is: http://identifiers.org/pubchem.compound/3380
is: C00080
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
name: proton
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

metaM 2mb2coa m
boundary condition: false
has only substance units: false
is: HMDB02054
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
is: SBO:0000247
initial amount: NaN
type: Species
name: 2-methylcrotonoyl-CoA(4-)
is: CHEBI:57337
initial concentration: 1.0
constant: false

metaR CYTK8
is described by: ECO:0000269
reversible: true
is: SBO:0000176
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,dATP)
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
fast: false

metaR PETOHMm hs
reactant: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000176
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
type: Reaction
name: phosphatidylethanolamine N-methyltransferase
kinetic law: MODEL1310110052#
reversible: false
is version of: http://identifiers.org/ec-code/2.1.1.17
is described by: ECO:0000254
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_bfda3d85_04bc_4539_a836_50c6a90d1f50
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:51079
has only substance units: false
name: NDUFA13
is: Q9P0J0

metaM HC00342 m
boundary condition: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
constant: false
name: cis-aconitate(3-)
is: SBO:0000247
is: CHEBI:16383
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species

metaR AHC
is: SBO:0000176
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
name: adenosylhomocysteinase
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.3.1.1
reversible: true
fast: false
kinetic law: MODEL1310110052#
is described by: ECO:0000269
reactant: MODEL1310110052#
type: Reaction

metaM g6p c
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
is: HMDB01401
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
name: D-Glucose 6-phosphate
initial concentration: 1.0
initial amount: NaN
constant: false
is: C00092
is: CHEBI:61548

http://identifiers.org/biomodels.db/MODEL1310110052#_483ee288_aa60_41ea_a850_7618667868e7
boundary condition: true
is: SBO:0000252
is: Q7Z7M8
has only substance units: false
constant: false
is encoded by: hsa:374907
type: Species
name: B3GNT8
initial concentration: NaN
initial amount: NaN

metaR DMNONCOACRNCPT1
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
kinetic law: MODEL1310110052#
product: MODEL1310110052#
name: DMNONCOACRNCPT1
fast: false
reactant: MODEL1310110052#
is described by: ECO:0000000
type: Reaction

metaR HISD
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110052#
fast: false
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/4.3.1.3
product: MODEL1310110052#
type: Reaction
name: histidase
is described by: ECO:0000269
reactant: MODEL1310110052#

metaM ksii core4 pre5 g
type: Species
is: HMDB00175
initial amount: NaN
constant: false
name: keratan sulfate II biosynthesis, precursor 5
is: C00130
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:58053
notes: FORMULA: C69H112N6O48X CHARGE: -1

metaR CYTK7
modifier: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is: SBO:0000176
is described by: ECO:0000269
name: cytidylate kinase (CMP,UTP)

http://identifiers.org/biomodels.db/MODEL1310110052#_2c0efbc9_c2ef_4b1a_9aec_d2428789e030
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
name: _AA177072_1_c
is encoded by: hsa:AA177072

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_e3b1b651_783b_4a7a_9186_e98882bad87c
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:11112
boundary condition: true
initial concentration: NaN
name: HIBADH
has only substance units: false
is: P31937
initial amount: NaN

metaM 1pyr5c m
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
boundary condition: false
initial amount: NaN
is: C03912
type: Species
has only substance units: false
is: CHEBI:15893
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01301
name: 1-Pyrroline-5-carboxylate

metaR r0730
reversible: false
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
kinetic law: MODEL1310110052#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110052#
is described by: ECO:0000000

metaR MGSA2
reactant: MODEL1310110052#
reversible: false
name: methyglyoxylate synthase 2 (from g3p)
fast: false
is: SBO:0000176
kinetic law: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:this rxn also represents the enzymatic conversion or non-enzymatic fragmentation of g3p to mthgxl - NCD
product: MODEL1310110052#

metaM hpdca c
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
is: HMDB02259
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:32366
initial amount: NaN
has only substance units: false
name: margarate
initial concentration: 1.0
constant: false

metaR r1299
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
kinetic law: MODEL1310110052#
is: SBO:0000185
product: MODEL1310110052#
name: Vesicular transport
is described by: ECO:0000000
reversible: false
fast: false
reactant: MODEL1310110052#

metaR 4MOPte
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
type: Reaction
fast: false
reversible: true
name: Transport of 4-methyl-2-oxopentanoate
reactant: MODEL1310110052#

metaM ppi x
is: SBO:0000247
initial concentration: 1.0
is: HMDB00250
is: CHEBI:33019
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false
type: Species
boundary condition: false
name: Diphosphate
is: C00013
constant: false

metaR ALASERNaEx
kinetic law: MODEL1310110052#
name: L-alanine/L-serine Na-dependent exchange (Ala-L in)
is: SBO:0000185
fast: false
reactant: MODEL1310110052#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110052#
type: Reaction
reversible: false
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_607d3cf5_0fe6_4c6a_8a4a_1d9f4e991fde
constant: false
name: DUT
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1854
boundary condition: true
is: P33316
type: Species
is: SBO:0000252
initial amount: NaN

metaR GLNLASEer
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
reversible: true
is: SBO:0000176
fast: false
product: MODEL1310110052#
name: gluconolactonase, endoplasmic reticulum
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_5666c2c7_b782_4134_a07e_1f70227024c9
boundary condition: true
constant: false
is: O60476
initial concentration: NaN
is: SBO:0000252
name: MAN1A2
type: Species
initial amount: NaN
is encoded by: hsa:10905
has only substance units: false

metaM gal e
is: CHEBI:0
is: C00124
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00143
has only substance units: false
name: D-Galactose
initial amount: NaN
is: SBO:0000247

metaR It
kinetic law: MODEL1310110052#
name: Iodide uniport
type: Reaction
modifier: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
is: SBO:0000185
reversible: true
product: MODEL1310110052#
is described by: ECO:0000269
reactant: MODEL1310110052#

metaR r1560
reactant: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110052#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_b25b8ba2_e422_4da6_bbf2_84caa7be527e
type: Species
boundary condition: true
is encoded by: hsa:83715
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
name: ESPN
is: B1AK53

http://identifiers.org/biomodels.db/MODEL1310110052#_053a9eed_4957_4bfc_ba19_f3711967f2d0
constant: false
type: Species
is: Q75T13
is encoded by: hsa:80055
initial amount: NaN
name: PGAP1
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM 5tedtricoa m
has only substance units: false
is: HMDB02288
initial concentration: 1.0
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
boundary condition: false
name: 5,8,11-tetradecatrienoylcoa

metaR FAOXC161C141m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:1-->C14:1)m
type: Reaction

metaR r1298
kinetic law: MODEL1310110052#
is: SBO:0000185
product: MODEL1310110052#
name: Vesicular transport
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110052#_bb27e173_cd27_42af_99c1_34ac1f8496be
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is: O00459
is encoded by: hsa:5296
name: PIK3R2

metaM ksi pre24 g
initial amount: NaN
has only substance units: false
is: C00130
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 24
constant: false
type: Species
is: SBO:0000247
is: CHEBI:58053
initial concentration: 1.0
boundary condition: false

metaR GGH 6THFe
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is: SBO:0000176
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (6THF), extracellular
fast: false

metaM msa m
name: 3-oxopropanoate
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
is: HMDB11111
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:33190
type: Species
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_b97ee173_e7dc_4362_a517_91233ff1b60d
boundary condition: true
is encoded by: hsa:55163
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q9NVS9
name: PNPO
constant: false
type: Species
initial amount: NaN

metaM 3ddcrn c
initial amount: NaN
is: HMDB00623
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C19H37NO5 CHARGE: 0
name: 3-hydroxydodecanoylcarnitine
constant: false
type: Species

metaM xylu D c
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:17140
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m1/s1
is: HMDB01644
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: D-xylulose
type: Species

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaR CYTK9
reactant: MODEL1310110052#
modifier: MODEL1310110052#
product: MODEL1310110052#
reversible: true
is: SBO:0000176
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
name: cytidylate kinase (CMP,dCTP)

http://identifiers.org/biomodels.db/MODEL1310110052#_ca7c4db6_21e3_4920_ae41_913145b207fe
type: Species
constant: false
initial concentration: NaN
name: RDH8
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:50700
is: Q9NYR8
has only substance units: false

metaM thf c
is: SBO:0000247
has only substance units: false
is: C00101
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB01846
type: Species
is: CHEBI:57453
name: 5,6,7,8-Tetrahydrofolate
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101

metaR C101CRNe
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decenoyl carnitine into extra cellular space
type: Reaction

metaM 4hphac c
name: 4-hydroxyphenylacetate
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:48999
type: Species
initial amount: NaN
is: HMDB00020
has only substance units: false
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
boundary condition: false

metaM 2oxoadp m
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
has only substance units: false
is: CHEBI:57499
initial concentration: 1.0
is: SBO:0000247
is: HMDB00225
constant: false
boundary condition: false
initial amount: NaN
type: Species
name: 2-oxoadipate(2-)

http://identifiers.org/biomodels.db/MODEL1310110052#_e2e84836_08c6_4401_8339_42df58361a1e
has only substance units: false
is encoded by: hsa:5294
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
is: P48736
initial amount: NaN
boundary condition: true
name: PIK3CG

metaR r1877
is: SBO:0000185
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
name: Y+LAT2 Utilized transport
product: MODEL1310110052#
reversible: false
type: Reaction
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110052#_47cd7e02_1137_4308_ba82_557c2fb952e4
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6487
name: ST3GAL3

metaM dmantipyrine c
name: demethylated antipyrine
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB06240
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H10N2O CHARGE: 0 INCHI: InChI=1/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-7,11H,1H3
type: Species

metaM prostgh2 c
is: HMDB01381
initial amount: NaN
initial concentration: 1.0
name: prostaglandin H2(1-)
boundary condition: false
type: Species
is: CHEBI:57405
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_b9f96175_33f2_4cb9_a2c5_8abeed647b87
has only substance units: false
is encoded by: hsa:5150
constant: false
type: Species
name: PDE7A
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_9efd1dda_1db3_4e85_b029_234a724f1f38
is encoded by: hsa:48
type: Species
is: P21399
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
name: ACO1
boundary condition: true
initial amount: NaN

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaR r1144
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10823827 NOTES:
product: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
is: SBO:0000185
reversible: false
reactant: MODEL1310110052#
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.18.6.3
kinetic law: MODEL1310110052#

metaM ppi n
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0
name: diphosphate(3-)
constant: false
is: HMDB00250
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:33019
type: Species

metaM HC00319 c
has only substance units: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
is: CHEBI:30794
name: Malonate
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_86992256_edd0_4d7d_a271_ebdf5f92e194
boundary condition: true
type: Species
name: DGKD
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8527
initial amount: NaN
has only substance units: false
constant: false

metaM ksi deg26 l
is: HMDB00061
constant: false
is: CHEBI:58343
boundary condition: false
name: keratan sulfate I, degradation product 26
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM dgdp m
is: CHEBI:58595
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
initial amount: NaN
initial concentration: 1.0
name: dGDP(2-)
is: HMDB00960
is: SBO:0000247
has only substance units: false
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_bd136b58_423a_41f3_9972_95cf65db66f8
has only substance units: false
is: P20933
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: AGA
is encoded by: hsa:175
type: Species
constant: false
boundary condition: true

metaR r1143
reactant: MODEL1310110052#
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10823827 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.18.6.3
fast: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110052#_f1024b85_0e7e_4f56_ae61_a1df29fe9761
is: SBO:0000252
is encoded by: hsa:80025
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q6P1K9
constant: false
name: PANK2

metaR GLNtm
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
kinetic law: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
name: L-glutamine transport via electroneutral transporter
is: SBO:0000185
fast: false
product: MODEL1310110052#
is described by: ECO:0000000

metaR r1876
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110052#
is described by: ECO:0000000
reversible: false
fast: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_949435b5_ac89_4fdd_9866_b8a577bf6d00
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q9HBH5
boundary condition: true
type: Species
is encoded by: hsa:57665
name: RDH14
constant: false

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

metaR CSBPASEly
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reversible: false
reactant: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
fast: false
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
is: SBO:0000176

metaM 3ddcrn e
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00791
has only substance units: false
notes: FORMULA: C19H37NO5 CHARGE: 0
initial concentration: 1.0
name: 3-hydroxydodecanoylcarnitine
is: C02838
type: Species
is: SBO:0000247

metaR XOLDIOLONEt
fast: false
kinetic law: MODEL1310110052#
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110052#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110052#

metaM dcholcoa x
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
constant: false
initial concentration: 1.0
type: Species
is: HMDB06292
initial amount: NaN
is: SBO:0000247
is: CHEBI:28701
boundary condition: false
name: chenodeoxycholoyl coenzyme a
has only substance units: false

metaM thf m
is: HMDB01846
initial amount: NaN
is: CHEBI:57453
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
constant: false
type: Species
boundary condition: false
has only substance units: false
name: 5,6,7,8-Tetrahydrofolate
is: C00101
is: SBO:0000247
initial concentration: 1.0

metaM dtmp m
name: dTMP
type: Species
is: SBO:0000247
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:26999
constant: false
is: HMDB01227
initial amount: NaN
is: C00364

metaM tethex3 e
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
is: HMDB02007
name: tetracosahexaenoic acid, n-3

metaR r1569
fast: false
kinetic law: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#

metaR PIPLC
kinetic law: MODEL1310110052#
name: phosphatidylinositol phospholipase C
product: MODEL1310110052#
reversible: false
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.4.11

http://identifiers.org/biomodels.db/MODEL1310110052#_f18885cf_8786_40e5_af28_12a07a894186
boundary condition: true
is encoded by: hsa:4709
has only substance units: false
type: Species
constant: false
name: NDUFB3
is: Q6IB80
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR O2St
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
product: MODEL1310110052#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: superoxide anion transport via diffusion (extracellular)
fast: false
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction

metaM tettet6coa c
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
name: tetracosatetraenoyl coenzyme A
is: HMDB06516
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205481
is: C16171
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
has only substance units: false

metaM lneldccoa m
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
name: linoelaidyl coenzyme A
boundary condition: false
is: http://identifiers.org/pubchem.compound/5462164
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: HMDB01064

http://identifiers.org/biomodels.db/MODEL1310110052#_03e2c0b0_55cb_4c15_90bc_f0a413359d21
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6482
is: Q11201
type: Species
is: SBO:0000252
has only substance units: false
name: ST3GAL1
initial amount: NaN

metaR r0739
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1
is: SBO:0000176
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110052#
is described by: ECO:0000000
modifier: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110052#_e90643f2_fb3b_45a3_9a8c_27086e2bb08d
name: ALDH1L1
constant: false
has only substance units: false
initial concentration: NaN
is: O75891
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:10840

http://identifiers.org/biomodels.db/MODEL1310110052#_1f0f902c_058b_47e7_9938_df2123c46eb5
boundary condition: true
is: B1AM93
has only substance units: false
is encoded by: hsa:4702
initial amount: NaN
name: NDUFA8
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species

metaM prostgh2 e
initial concentration: 1.0
boundary condition: false
name: prostaglandin H2(1-)
type: Species
is: CHEBI:57405
is: SBO:0000247
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial amount: NaN
is: HMDB01381
has only substance units: false

metaM dolmanp L c
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
type: Species
is: CHEBI:15809
initial amount: NaN
name: Dolichyl phosphate D-mannose, human liver homolog
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: SBO:0000247

metaR FAOXC161C141x
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C16:1-->C14:1)x
type: Reaction

metaM xoltetrol m
boundary condition: false
initial amount: NaN
is: HMDB01231
type: Species
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:17278
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_32297f31_5e91_4296_82b4_6eb1637bf25a
is: Q53H96
is encoded by: hsa:65263
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
name: PYCRL
boundary condition: true

metaR PSDm hs
modifier: MODEL1310110052#
product: MODEL1310110052#
reversible: false
reactant: MODEL1310110052#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
is version of: http://identifiers.org/ec-code/4.1.1.65
name: Phosphatidylserine decarboxylase
kinetic law: MODEL1310110052#
fast: false
is: SBO:0000176

metaM hdd2coa c
initial amount: NaN
name: trans-Hexadec-2-enoyl-CoA
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
initial concentration: 1.0
is: HMDB03945
boundary condition: false
is: CHEBI:61526
is: SBO:0000247
type: Species
has only substance units: false
constant: false
is: C05272

metaR 3HCO3 NAt
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000134
product: MODEL1310110052#
reactant: MODEL1310110052#
name: 3HCO3_NAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
kinetic law: MODEL1310110052#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_aab111f5_9219_4772_bed4_dc240395a195
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: AHCY
type: Species
is encoded by: hsa:191
has only substance units: false
is: B3KUN3
boundary condition: true
constant: false

metaR L LACt2r
fast: false
is described by: ECO:0000269
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
kinetic law: MODEL1310110052#
is: SBO:0000185
reactant: MODEL1310110052#
name: L-lactate reversible transport via proton symport
reversible: true
type: Reaction
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_634841fc_d0b1_4155_940d_2692dbd80841
is encoded by: hsa:5315
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
name: PKM2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_e22bc022_8dc1_4d36_86ff_bb55540f8f86
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:54576
initial amount: NaN
is: Q5DSZ6
is: SBO:0000252
boundary condition: true
has only substance units: false
name: UGT1A8

metaM tethex3 c
is: HMDB02007
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
initial concentration: 1.0
name: tetracosahexaenoic acid, n-3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_35eca043_819b_488c_99bb_0b9380690f6a
name: SLC6A4
initial concentration: NaN
is: P31645
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:6532
constant: false

metaR EX 3deccrn
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydecanoyl carnitine
type: Reaction

metaM ppi m
initial concentration: 1.0
is: CHEBI:33019
initial amount: NaN
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
is: HMDB00250
name: Diphosphate
constant: false
boundary condition: false
has only substance units: false
is: C00013

metaM cortsn r
boundary condition: false
constant: false
is: HMDB02802
notes: FORMULA: C21H28O5 CHARGE: 0 INCHI: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00762
initial concentration: 1.0
name: cortisone
is: SBO:0000247
has only substance units: false
is: CHEBI:16962
type: Species
initial amount: NaN

metaR SERGLYexR
is: SBO:0000185
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
reversible: true
is described by: ECO:0000304
product: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-Serine/Glycine reversible exchange
fast: false

metaR RE1447M
reactant: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000176
name: RE1447
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.41
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
reversible: true
fast: false

metaR ST8SIA12
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
reversible: false
modifier: MODEL1310110052#
name: Beta-galactoside alpha-2,3-sialyltransferase
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.99.8
kinetic law: MODEL1310110052#
fast: false

metaM 2docohexecoa m
constant: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
name: 2,7,10,13,16,19-docosahexenoylcoa
initial concentration: 1.0

metaR FBA4
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
product: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (226.2) or (229.1) or (226.3) or (230.1) or (226.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.2.13 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.2.13
modifier: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000269
fast: false
is: SBO:0000176

metaR r1566
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
type: Reaction

metaM ppi r
type: Species
is: SBO:0000247
constant: false
is: HMDB00250
has only substance units: false
initial amount: NaN
is: C00013
initial concentration: 1.0
is: CHEBI:33019
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
name: Diphosphate

metaR ACACtx
type: Reaction
reversible: true
fast: false
product: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
reactant: MODEL1310110052#
name: acetoacetate intracellular transport unknown mechanism

metaR STRDNCCPT2
fast: false
product: MODEL1310110052#
is described by: ECO:0000000
name: carnitine transferase
reactant: MODEL1310110052#
type: Reaction
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_38bf6797_b005_46ea_91d3_078af7a9f181
is: Q8TF71
type: Species
is: SBO:0000252
is encoded by: hsa:117247
name: SLC16A10
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR THRSERNaEx
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
name: L-serine/L-threonine Na-dependent exchange (Thr-L in)
reversible: false
is described by: ECO:0000269
fast: false
product: MODEL1310110052#
is: SBO:0000185

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

metaM xu1p D c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h3,5-7,9H,1-2H2,(H2,10,11,12)/t3-,5-/m1/s1
type: Species
initial amount: NaN
boundary condition: false
is: HMDB06534
constant: false
name: D-Xylulose 1-phosphate

metaM hpdcacrn c
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
name: heptadecanoyl carnitine
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
initial concentration: 1.0
is: HMDB06210
has only substance units: false
boundary condition: false

metaM tetdec2crn c
is: SBO:0000247
notes: FORMULA: C21H37NO4 CHARGE: 0
type: Species
name: tetradecadienoyl carnitine
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB02014

http://identifiers.org/biomodels.db/MODEL1310110052#_5bd2c8e0_f495_4ebf_8532_e9a5a523a0de
type: Species
name: PRPS2
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:5634
is: P11908
is: SBO:0000252
initial concentration: NaN

metaR HMGCOASim
is described by: ECO:0000269
product: MODEL1310110052#
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.3.10
name: Hydroxymethylglutaryl CoA synthase (ir)
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_0fe91528_31da_4cab_af28_b3c06ddc47ca
has only substance units: false
is encoded by: hsa:4701
initial amount: NaN
initial concentration: NaN
is: Q6FG42
type: Species
constant: false
name: NDUFA7
boundary condition: true
is: SBO:0000252

metaR C141OHc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_8713f236_354a_47d2_ab85_b5d03dc18b1d
constant: false
initial concentration: NaN
name: PIGC
has only substance units: false
initial amount: NaN
is encoded by: hsa:5279
type: Species
boundary condition: true
is: SBO:0000252
is: Q92535

metaR r1292
product: MODEL1310110052#
reversible: true
name: Postulated transport reaction
kinetic law: MODEL1310110052#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_26cc9fbe_9e4d_4e77_8cce_4e55006d1be8
has only substance units: false
initial amount: NaN
is encoded by: hsa:5283
is: Q14442
is: SBO:0000252
name: PIGH
type: Species
constant: false
boundary condition: true
initial concentration: NaN

metaR MOGAT
reactant: MODEL1310110052#
type: Reaction
is: SBO:0000176
product: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (116255.1) or (80168.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 2 AUTHORS: NOTES:FULLR corresponds to acyl/R groups in texts. NJ
name: monoacylglycerol acyltransferase
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.22

metaR DPCOAPPe
kinetic law: MODEL1310110052#
is described by: ECO:0000134
name: Pyrophasphatase (dephospho-CoA, extracellular)
reactant: MODEL1310110052#
product: MODEL1310110052#
fast: false
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110052#_0dbc2b37_6397_437a_bd58_cc5b9076cee7
is encoded by: hsa:3177
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: SLC29A2
constant: false
is: Q14542
boundary condition: true

metaR r1565
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110052#
type: Reaction
is: SBO:0000185

metaM c10dc c
boundary condition: false
is: HMDB00651
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: sebacoyl carnitine
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C17H30NO6 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110052#_f5e00304_32b7_463a_9efb_e6f8df00bde5
name: _206_1_c
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:206

metaR STRDNCCPT1
modifier: MODEL1310110052#
reactant: MODEL1310110052#
reversible: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: carnitine O-palmitoyltransferase
fast: false
product: MODEL1310110052#

metaM sprm c
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB01256
has only substance units: false
constant: false
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
initial concentration: 1.0
name: spermine(4+)
is: CHEBI:45725

http://identifiers.org/biomodels.db/MODEL1310110052#_c71457b6_b47e_4128_a913_bb724a6d05bb
type: Species
initial concentration: NaN
is encoded by: hsa:10587
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
name: TXNRD2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_2254e6a4_578a_4c56_b0db_80e93db3cd2b
is encoded by: hsa:516
is encoded by: hsa:515
has part: Q6IBB3
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:522
boundary condition: true
has part: P46459
initial amount: NaN
is encoded by: hsa:4905
is: SBO:0000297
has part: O75964
is encoded by: hsa:9551
has part: P05496
constant: false
has part: Q08ET0
is encoded by: hsa:10632
has only substance units: false
has part: P56385
is encoded by: hsa:10476
type: Species
has part: A0PJH2
is encoded by: hsa:521

metaR RDH1
is: SBO:0000176
kinetic law: MODEL1310110052#
is described by: ECO:0000269
modifier: MODEL1310110052#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.315
fast: false
product: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
type: Reaction
name: retinol dehydrogenase (all-trans)

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_c5937f36_f130_424e_82c2_a587b67aeceb
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:5152
is: SBO:0000252
constant: false
name: PDE9A
initial concentration: NaN
type: Species

metaR r0735
product: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
type: Reaction
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110052#_488b6609_d0b0_4d71_8d52_dfa068200e20
constant: false
name: _AA532636_1_m
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:AA532636
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM lnlncg r
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:32391
type: Species
is: HMDB03073
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
name: gamma-linolenate

metaM dgdp n
name: dGDP(2-)
is: CHEBI:58595
boundary condition: false
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00960
initial amount: NaN

metaR DNDPt9m
type: Reaction
modifier: MODEL1310110052#
is: SBO:0000185
fast: false
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
name: dADP transport via dTDP antiport
reactant: MODEL1310110052#
is described by: ECO:0000269
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_9ef2737c_f474_48e6_96bc_2abcf9af374c
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaR r1291
fast: false
product: MODEL1310110052#
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Postulated transport reaction

metaR THBPT4ACAMDASE
modifier: MODEL1310110052#
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
reactant: MODEL1310110052#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/4.2.1.96

metaR r1568
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110052#
fast: false
type: Reaction
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_faed29cb_1267_417a_8255_81d84771a173
is: Q9BY32
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:3704
initial concentration: NaN
boundary condition: true
has only substance units: false
name: ITPA

metaR CSNAT2x
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
modifier: MODEL1310110052#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.137
is version of: http://identifiers.org/ec-code/2.3.1.7
reactant: MODEL1310110052#
fast: false

metaM lac D c
constant: false
is: HMDB01311
initial amount: NaN
is: SBO:0000247
name: (R)-lactate
has only substance units: false
is: CHEBI:16004
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1

metaR RE1447N
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
name: RE1447
product: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction

metaM gal l
is: HMDB00143
is: SBO:0000247
constant: false
is: CHEBI:12936
has only substance units: false
initial amount: NaN
boundary condition: false
name: D-galactose
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_c9517a9c_c937_4815_9e3e_a8280d2a80ba
has only substance units: false
is encoded by: hsa:3033
initial concentration: NaN
initial amount: NaN
is: Q16836
boundary condition: true
constant: false
is: SBO:0000252
name: HADH
type: Species

metaM tetdec2crn e
is: HMDB05066
notes: FORMULA: C21H37NO4 CHARGE: 0
type: Species
name: tetradecadienoyl carnitine
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM dec47dicoa m
constant: false
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
name: 4,7-decadienoylcoa
initial concentration: 1.0
initial amount: NaN

metaR AG13T8g
type: Reaction
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110052#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110052#

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaM dcholcoa r
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
constant: false
name: chenodeoxycholoyl coenzyme a
type: Species
initial concentration: 1.0
is: HMDB06292
is: CHEBI:28701
is: SBO:0000247

metaR r1567
reactant: MODEL1310110052#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110052#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110052#

metaR ADPACTD
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport into cytosol (diffusion)
type: Reaction

metaM sprm e
name: spermine(4+)
initial amount: NaN
type: Species
boundary condition: false
is: HMDB01256
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
is: CHEBI:45725
is: SBO:0000247

metaR COQ6m
notes: GENE_ASSOCIATION: (51004.1) or (51004.2) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.13.12.- IT
reactant: MODEL1310110052#
type: Reaction
is described by: ECO:0000269
fast: false
name: Ubiquinone biosynthesis monooxgenase COQ6
kinetic law: MODEL1310110052#
is: SBO:0000176
modifier: MODEL1310110052#
product: MODEL1310110052#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110052#_ba80c4ec_b7b7_42e8_9de9_162d06e0c79b
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: P04054
boundary condition: true
name: PLA2G1B
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5319

http://identifiers.org/biomodels.db/MODEL1310110052#_65165655_e42d_4446_b70b_d736d0516e7d
constant: false
initial amount: NaN
name: DPYD
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:1806
has only substance units: false
initial concentration: NaN
is: Q12882

metaM gacpail hs r
type: Species
is: SBO:0000247
boundary condition: false
is: C00092
initial amount: NaN
has only substance units: false
is: HMDB01401
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
name: glucosaminyl-acylphosphatidylinositol
is: CHEBI:61548
constant: false
initial concentration: 1.0

metaR SGALSIDEtg
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
product: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
name: sgalside hs intracellular transport
is: SBO:0000185

metaR DLNLCGCPT1
fast: false
reactant: MODEL1310110052#
modifier: MODEL1310110052#
reversible: false
is described by: ECO:0000000
type: Reaction
name: carnitine O-palmitoyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110052#

metaR SUBERICACT
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of suberic acid for formation of suberyl carnitine
type: Reaction

metaR S6TASE25ly
is described by: ECO:0000000
modifier: MODEL1310110052#
reversible: true
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
name: galactose-6-sulfate sulfatase, lysosomal
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
is: SBO:0000176
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18

metaM ksii core4 e
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
name: keratan sulfate II (core 4-linked)
is: CHEBI:17268
is: HMDB00211

metaM ksii core2 pre8 g
type: Species
notes: FORMULA: C75H121N6O56SX CHARGE: -2
initial amount: NaN
is: CHEBI:58053
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: keratan sulfate II biosynthesis, precursor 8
is: HMDB00175
is: C00130

metaR Htx
reactant: MODEL1310110052#
reversible: true
name: H transporter, peroxisome
product: MODEL1310110052#
is: SBO:0000185
kinetic law: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_fed4ea64_109d_4b76_a5de_b63c52b0c37b
has only substance units: false
boundary condition: true
is encoded by: hsa:11226
initial amount: NaN
constant: false
name: GALNT6
is: Q8NCL4
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_636e199b_12ef_4633_9714_67289853a7d5
initial concentration: NaN
type: Species
has only substance units: false
name: ABCB4
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5244

metaM cholp g
is: CHEBI:295975
boundary condition: false
constant: false
name: choline phosphate(1-)
type: Species
is: SBO:0000247
is: C00588
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR DM dsT antigen g
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dsT antigen(g)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_99022702_c6b2_4f31_aa24_6cc75be0c15e
name: ALDH1B1
is encoded by: hsa:219
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is: P30837

metaM Tn antigen l
boundary condition: false
has only substance units: false
name: Tn antigen
constant: false
initial amount: NaN
notes: FORMULA: C8H14NO5X CHARGE: 0
is: SBO:0000247
type: Species
is: C04383
initial concentration: 1.0

metaR VALtec
type: Reaction
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
is: SBO:0000185
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
name: L-valine transport via diffusion (extracellular to cytosol)
product: MODEL1310110052#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110052#
reversible: true

metaM 5adtststerones e
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
constant: false
name: 5alpha-Dihydrotestosterone sulfate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
is: HMDB06278

metaR C16DCe
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexadecanedioic acid mono-L-carnitine ester into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_ec6ad053_9572_493b_98b5_29735ab123d0
boundary condition: true
initial concentration: NaN
type: Species
is: Q8NEM3
is encoded by: hsa:9194
has only substance units: false
is: SBO:0000252
constant: false
name: SLC16A7
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_d04e48ce_ce7f_41b8_8256_c057e44ff9ff
name: NDUFA6
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is: P56556
is encoded by: hsa:4700
initial amount: NaN

metaR HSD11B2r
fast: false
is: SBO:0000176
reversible: true
is described by: ECO:0000269
name: 11-beta-hydroxysteroid dehydrogenase type 2
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (3291.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
type: Reaction
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.1.146

metaM h g
has only substance units: false
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial amount: NaN
is: SBO:0000247
name: proton
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:24636

http://identifiers.org/biomodels.db/MODEL1310110052#_b63c33d8_134e_405f_ac8c_52198402fc15
is: SBO:0000252
type: Species
is encoded by: hsa:159
constant: false
initial concentration: NaN
initial amount: NaN
name: ADSS
is: P30520
has only substance units: false
boundary condition: true

metaR ARGtiDF
name: L-arginine transport via diffusion (extracellular to cytosol)
fast: false
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
is: SBO:0000185
type: Reaction
reactant: MODEL1310110052#
is described by: ECO:0000269
modifier: MODEL1310110052#
product: MODEL1310110052#
reversible: false
kinetic law: MODEL1310110052#

metaR PI345P5P
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.86
product: MODEL1310110052#
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.3.56
reversible: false
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.36
modifier: MODEL1310110052#
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
type: Reaction
kinetic law: MODEL1310110052#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_8ea3eaa8_d2d7_4d59_b4b8_6f3e693a7d00
constant: false
is: SBO:0000252
name: SLC4A3
is: P48751
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6508
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_378c9941_4546_41e0_905b_70c22ff7945b
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:7263
is: Q16762
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
name: TST

metaM man l
type: Species
constant: false
has only substance units: false
is: CHEBI:16024
initial concentration: 1.0
name: D-mannose
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00169
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159

metaR CYTK1m
type: Reaction
fast: false
reactant: MODEL1310110052#
is: SBO:0000176
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
name: cytidylate kinase (CMP),mitochondrial
product: MODEL1310110052#

metaR EX HC00822 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chitobiose exchange
type: Reaction

metaM tchola e
is: HMDB00036
initial concentration: 1.0
initial amount: NaN
name: taurocholic acid
constant: false
boundary condition: false
notes: FORMULA: C26H45NO7S CHARGE: 0
is: SBO:0000247
type: Species
has only substance units: false

metaM retn e
initial amount: NaN
has only substance units: false
is: HMDB01852
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
name: all-trans-retinoate
is: CHEBI:35291
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species

metaR RE1573M
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
reversible: true
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
is version of: http://identifiers.org/ec-code/5.3.3.8
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110052#
name: RE1573
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110052#
type: Reaction

metaR TSULt4 3
name: thiosulfate transport via sodium symport
is: SBO:0000185
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000269
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110052#

metaR C14STRr
is: SBO:0000176
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.3.1.70
is described by: ECO:0000134
modifier: MODEL1310110052#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
product: MODEL1310110052#
name: C-14 sterol reductase
reversible: false
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_313e5fc8_f5a2_4919_b001_47c59461a4e2
initial concentration: NaN
type: Species
name: ALDH3B2
constant: false
is encoded by: hsa:222
is: P48448
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM glx c
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:36655
is: HMDB00119
boundary condition: false
name: glyoxylate
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
has only substance units: false
is: SBO:0000247

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaM 5adtststerones c
has only substance units: false
type: Species
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
name: 5alpha-Dihydrotestosterone sulfate
initial concentration: 1.0
is: SBO:0000247
is: HMDB06278
constant: false
initial amount: NaN
boundary condition: false

metaR RE1826C
is: SBO:0000176
kinetic law: MODEL1310110052#
reversible: false
fast: false
type: Reaction
is described by: ECO:0000000
name: RE1826
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
product: MODEL1310110052#
reactant: MODEL1310110052#

metaM ksi pre7 g
is: C00130
is: SBO:0000247
is: HMDB00175
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 7
type: Species
notes: FORMULA: C115H187N8O85SX CHARGE: -2
is: CHEBI:58053

metaR r2202
is: SBO:0000185
product: MODEL1310110052#
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
reversible: true
fast: false
reactant: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5

metaR DLNLCGCPT2
modifier: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000176
fast: false
reversible: false
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR r1538
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
product: MODEL1310110052#
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000185
type: Reaction
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
modifier: MODEL1310110052#

metaM nad m
name: Nicotinamide adenine dinucleotide
initial concentration: 1.0
type: Species
is: CHEBI:57540
is: http://identifiers.org/pubchem.compound/3305
constant: false
is: HMDB00902
is: C00003
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false

metaM for r
name: Formate
is: CHEBI:15740
boundary condition: false
has only substance units: false
constant: false
is: C00058
is: HMDB00142
type: Species
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM 3hmp m
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
type: Species
name: 3-hydroxy-2-methylpropanoate
is: HMDB00023
is: CHEBI:11805
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_76bd1b31_05ea_4b86_850f_1a291684ac1b
type: Species
is encoded by: hsa:8876
is encoded by: hsa:8875
is encoded by: hsa:55350
initial concentration: NaN
boundary condition: true
is: SBO:0000297
name: VNN3:VNN2:VNN1
has part: A8K7W0
constant: false
has part: O95497
initial amount: NaN
has only substance units: false

metaM pheacgln e
is: SBO:0000247
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
type: Species
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
boundary condition: false
is: HMDB06344
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:58310
initial amount: NaN

metaM Tn antigen g
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C8H14NO5X CHARGE: 0
has only substance units: false
is: SBO:0000247
boundary condition: false
name: Tn antigen
type: Species
is: C04383

metaM dolp L c
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial concentration: 1.0
name: dolichyl phosphate(2-)
boundary condition: false
is: CHEBI:57683
type: Species

metaR r0475
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: true
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
fast: false

metaM h e
is: C00080
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
name: proton
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: "
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_64e2ec07_89ce_4ce7_be94_fc7c2b8ae7a2
is: O95395
is encoded by: hsa:9245
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
name: GCNT3
has only substance units: false
initial amount: NaN

metaR ATPtm
reversible: false
fast: false
reactant: MODEL1310110052#
is: SBO:0000185
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110052#
name: ADP/ATP transporter, mitochondrial
type: Reaction
kinetic law: MODEL1310110052#
product: MODEL1310110052#

metaM ppi e
is: CHEBI:33019
initial amount: NaN
is: HMDB00250
type: Species
name: Diphosphate
constant: false
is: SBO:0000247
initial concentration: 1.0
is: C00013
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false

metaR EICOSTETCRNt
is described by: ECO:0000000
product: MODEL1310110052#
reversible: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110052#

metaM 3otdcoa m
is: CHEBI:28726
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
name: 3-Oxotetradecanoyl-CoA
type: Species
is: HMDB03935
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_bff48af6_34c5_496a_bfc5_12f456205e5c
is encoded by: hsa:954
is: SBO:0000252
has only substance units: false
is: Q5SPY7
type: Species
boundary condition: true
initial amount: NaN
name: ENTPD2
initial concentration: NaN
constant: false

metaM 3pg m
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
constant: false
is: CHEBI:58272
initial amount: NaN
is: HMDB00807
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR FADH2ETC
fast: false
type: Reaction
reactant: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110052#
is described by: ECO:0000134
name: Complex II reaction for respiratory chain
reversible: false

metaR r2201
reactant: MODEL1310110052#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true
kinetic law: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
modifier: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_afcc1778_591d_4955_91bd_5079318aafda
is encoded by: hsa:8560
type: Species
boundary condition: true
name: DEGS1
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR r0474
type: Reaction
product: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
is: SBO:0000176
reversible: true
is described by: ECO:0000000
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:

metaR EX 2mcit LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Methylcitrate exchange
type: Reaction

metaM ksii core4 pre6 g
is: CHEBI:28067
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 6
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C69H111N6O51SX CHARGE: -2

metaM cys L e
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: HMDB00574
has only substance units: false
initial concentration: 1.0
name: L-cysteine
type: Species
initial amount: NaN
constant: false
is: CHEBI:17561
boundary condition: false
is: SBO:0000247

metaM cholp c
has only substance units: false
name: choline phosphate(1-)
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:295975

metaM crm hs r
has only substance units: false
is: CHEBI:52639
initial amount: NaN
constant: false
name: N-acylsphingosine
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
type: Species

metaR GLYt2r
is: SBO:0000185
name: glycine reversible transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
fast: false
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction
reversible: true
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000304

metaR C121CPT1
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecenoylcarnitine
type: Reaction

metaR ATP2ter
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: AMP/ATP transporter, endoplasmic reticulum
reactant: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction
reversible: true
fast: false
is: SBO:0000185

metaM occoa x
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: C01944
is: CHEBI:57386
constant: false
type: Species
name: Octanoyl-CoA (n-C8:0CoA)
is: HMDB01070

metaR r2200
kinetic law: MODEL1310110052#
product: MODEL1310110052#
modifier: MODEL1310110052#
is: SBO:0000185
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110052#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM 5adtststerone c
is: CHEBI:16330
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
name: 17beta-hydroxy-5alpha-androstan-3-one
has only substance units: false
initial concentration: 1.0
is: HMDB02961
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917

metaM pheacgln c
initial amount: NaN
is: HMDB06344
is: CHEBI:58310
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
constant: false
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false

metaM h c
is: SBO:0000247
has only substance units: false
is: C00080
initial concentration: 1.0
type: Species
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: "
initial amount: NaN
constant: false
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
boundary condition: false

metaR ACGPID
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
modifier: MODEL1310110052#
name: N-acetylglucosaminylphosphatidylinositol deacetylase
is described by: ECO:0000269
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.89

http://identifiers.org/biomodels.db/MODEL1310110052#_60cf697b_999e_435c_a6fa_95f5b3b74068
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:64087
has only substance units: false
has part: Q96RQ3
has part: Q9HCC0
is encoded by: hsa:56922
boundary condition: true
name: MCCC1:MCCC2
constant: false
is: SBO:0000297

metaM dmhptcoa m
has only substance units: false
name: 2,6 dimethylheptanoyl-CoA
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C30H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C30H52N7O17P3S/c1-17(2)7-6-8-18(3)29(42)58-12-11-32-20(38)9-10-33-27(41)24(40)30(4,5)14-51-57(48,49)54-56(46,47)50-13-19-23(53-55(43,44)45)22(39)28(52-19)37-16-36-21-25(31)34-15-35-26(21)37/h15-19,22-24,28,39-40H,6-14H2,1-5H3,(H,32,38)(H,33,41)(H,46,47)(H,48,49)(H2,31,34,35)(H2,43,44,45)/p-4/t18-,19+,22-,23-,24?,28+/m0/s1
is: HMDB06258
type: Species
initial amount: NaN
constant: false

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaM pglyc hs c
is: CHEBI:21338
initial amount: NaN
notes: FORMULA: CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
is: HMDB02704
has only substance units: false
type: Species
boundary condition: false
name: pglyc_hs[c]
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_b63bd9d6_480e_4058_a7cd_a6082ec4eb13
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:4720
has only substance units: false
is: B7Z792
type: Species
name: NDUFS2
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_0fe46eba_183f_4756_a54e_5a3cba6a87de
name: ALDOB
is encoded by: hsa:229
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: P05062
initial amount: NaN
boundary condition: true
type: Species

metaR G14T17g
modifier: MODEL1310110052#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
fast: false
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.38

metaM stcoa m
boundary condition: false
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
initial concentration: 1.0
has only substance units: false
is: HMDB01114
is: SBO:0000247
initial amount: NaN
is: C00412
is: CHEBI:57394
constant: false
type: Species
name: Stearoyl-CoA (n-C18:0CoA)

metaR DOLPGT2 Ler
kinetic law: MODEL1310110052#
fast: false
reversible: false
is: SBO:0000176
modifier: MODEL1310110052#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.265
reactant: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD

metaR NACHEX27ly
kinetic law: MODEL1310110052#
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110052#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
is: SBO:0000176
reversible: false

metaR BPNT
product: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
type: Reaction
kinetic law: MODEL1310110052#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.7
name: 3',5'-bisphosphate nucleotidase
reversible: false
is: SBO:0000176

metaR 2HCO3 NAt
kinetic law: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
is: SBO:0000185
modifier: MODEL1310110052#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110052#
reversible: true
fast: false

metaR HIStiDF
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000269
modifier: MODEL1310110052#
name: L-histidine transport via diffusion (extracellular to cytosol)
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES:SAB
type: Reaction
fast: false
is: SBO:0000185
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110052#_f551cb47_9f74_48c9_bfa4_74b24495c6e4
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
name: COQ6
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:51004
is: Q9Y2Z9

metaR PYDXK
product: MODEL1310110052#
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.35
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: pyridoxal kinase
reversible: false
fast: false
reactant: MODEL1310110052#
is described by: ECO:0000269

metaM CE2838 e
has only substance units: false
name: maltononaose
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
is: SBO:0000247
type: Species
is: C01936

metaM gpi sig r
is: SBO:0000247
initial amount: NaN
is: CHEBI:58190
notes: FORMULA: Y CHARGE: 0
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00224

metaR LDH D
reactant: MODEL1310110052#
is described by: ECO:0000304
is: SBO:0000176
name: D-lactate dehydrogenase
fast: false
product: MODEL1310110052#
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
is version of: http://identifiers.org/ec-code/1.1.2.4
type: Reaction
reversible: true

metaM 5adtststerone e
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB02961
name: 17beta-hydroxy-5alpha-androstan-3-one
initial concentration: 1.0
has only substance units: false
is: CHEBI:16330
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
constant: false

metaR r0472
reversible: true
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_bf829fb0_0047_4dba_bc3c_9d35b7580111
has only substance units: false
type: Species
name: UPP2
is: O95045
is encoded by: hsa:151531
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_41a02468_46c1_4fba_a3ff_b52574618100
initial amount: NaN
type: Species
is encoded by: hsa:10455
constant: false
is: O75521
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: ECI2

metaR LYStm
product: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110052#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110052#
fast: false
name: Lysine mitochondrial transport via ornithine carrier

metaM cholcoaone x
boundary condition: false
has only substance units: false
type: Species
is: HMDB06891
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
is: CHEBI:58507
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN

metaM pglyc hs e
constant: false
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:60523
type: Species
name: phosphatidylglycerol(1-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_a4fc3c63_8c35_48e8_a844_29c7eecb9ae2
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3098
initial amount: NaN
type: Species
constant: false
is: Q59FD4
name: HK1

metaR FRDPtc
name: lipid, flip-flop intracellular transport
type: Reaction
reversible: true
reactant: MODEL1310110052#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000185

metaM stcrn c
is: HMDB00848
type: Species
boundary condition: false
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: stearoylcarnitine
constant: false

metaM Lcystin c
initial amount: NaN
type: Species
name: L-cystine
initial concentration: 1.0
has only substance units: false
is: CHEBI:16283
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: SBO:0000247
is: HMDB00192
boundary condition: false
constant: false

metaR BILGLCURtr
type: Reaction
is described by: ECO:0000000
product: MODEL1310110052#
reversible: true
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
is: SBO:0000185
fast: false
name: glucuronidated compound transport
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_24bf4267_7f06_4f3d_a87e_612fbc149b44
has only substance units: false
is: O00154
is: SBO:0000252
is encoded by: hsa:11332
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
boundary condition: true
name: ACOT7

metaM glyc R c
type: Species
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
constant: false
is: CHEBI:16659
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00139
is: SBO:0000247
name: D-glycerate
boundary condition: false

metaM 3ddecdicoa m
is: HMDB03952
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial amount: NaN
name: 3,6-dodecadienoylcoa
is: C05280
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_cb80f89b_5f72_485e_b226_e8d1144c2c05
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI378339
name: _AI378339_1_m
type: Species
has only substance units: false
constant: false
boundary condition: true

metaM ura e
has only substance units: false
constant: false
name: uracil
is: CHEBI:17568
type: Species
boundary condition: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
initial concentration: 1.0
initial amount: NaN
is: HMDB00300
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_d462e22a_9262_4873_b35c_ac60f83321aa
name: HMGCS2
is encoded by: hsa:3158
initial concentration: NaN
initial amount: NaN
is: P54868
constant: false
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false

metaM tetd7ecoa m
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
is: HMDB13109
name: 7-tetradecenoylcoa

metaM h r
is: C00080
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:24636
name: proton
constant: false
is: SBO:0000247

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_b4a67706_07b2_487c_b26f_55ec9c9d3bbb
initial amount: NaN
is: B2RD24
has only substance units: false
constant: false
boundary condition: true
type: Species
name: MTHFD1L
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:25902

metaM 3aib D m
constant: false
boundary condition: false
is: C03265
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB02299
has only substance units: false
name: D-3-Amino-isobutanoate
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_b75dd6b9_7871_436b_9fa7_aa27c8744841
has only substance units: false
is encoded by: hsa:56052
name: ALG1
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
is: Q9BT22
initial amount: NaN
type: Species

metaR ALR2
is version of: http://identifiers.org/ec-code/1.1.1.21
type: Reaction
kinetic law: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.2
is described by: ECO:0000269
fast: false
is: SBO:0000176
name: aldose reductase (methylglyoxal)
reversible: false
reactant: MODEL1310110052#
modifier: MODEL1310110052#

metaR FAOXC2251836m
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110052#
type: Reaction
is: SBO:0000176
reversible: false
reactant: MODEL1310110052#
fast: false
name: Beta oxidation of fatty acid
kinetic law: MODEL1310110052#
is described by: ECO:0000000
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaM frdp c
constant: false
is: C00448
is: SBO:0000247
type: Species
is: CHEBI:175763
name: Farnesyl diphosphate
is: HMDB00961
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448

metaM pac c
is: CHEBI:18401
initial concentration: 1.0
type: Species
boundary condition: false
name: phenylacetate
is: HMDB00209
constant: false
initial amount: NaN
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
has only substance units: false
is: SBO:0000247

metaR FACOAL240
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
reversible: true
kinetic law: MODEL1310110052#
name: fatty-acid--CoA ligase
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110052#

metaM nad x
boundary condition: false
type: Species
name: Nicotinamide adenine dinucleotide
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3305
is: CHEBI:57540
is: C00003
is: HMDB00902
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false

metaM 2hexdtricoa m
initial amount: NaN
type: Species
is: HMDB02288
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: 2,7,10-hexadecatrienoylcoa
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247

metaR AG13T13g
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
modifier: MODEL1310110052#
type: Reaction
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_9c7c68cd_5691_47ab_b4d2_b2fed8616b35
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:29920
name: PYCR2
initial amount: NaN
is: Q96C36
boundary condition: true

metaM phytcoa c
is: HMDB01359
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
is: CHEBI:57391
initial concentration: 1.0
name: phytanoyl-CoA(4-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_262b4497_1181_4f60_8052_ab64ab4ca892
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:1719
boundary condition: true
name: DHFR
is: P00374
initial concentration: NaN

metaM cholcoads x
initial concentration: 1.0
is: SBO:0000247
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
is: CHEBI:27505
has only substance units: false
constant: false
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
is: HMDB06889
initial amount: NaN
boundary condition: false
type: Species

metaR ALAtN1
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reversible: true
product: MODEL1310110052#
name: Alanine transport (Na, H coupled)

metaR r0055
reversible: true
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.2.7
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
reactant: MODEL1310110052#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.2.8
is: SBO:0000176

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR PHEtec
reversible: true
product: MODEL1310110052#
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (117247.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462,PMID:14624363,PMID:15659399 NOTES:SAB
is described by: ECO:0000269
name: L-phenylalanine transport via diffusion (extracellular to cytosol)
modifier: MODEL1310110052#

metaR MECOALm
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
kinetic law: MODEL1310110052#
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.5
is described by: ECO:0000212
reversible: true
modifier: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000176
fast: false

metaM 3pg c
is: C00197
is: http://identifiers.org/pubchem.compound/3497
is: SBO:0000247
constant: false
is: HMDB00807
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
name: 3-Phospho-D-glycerate
is: CHEBI:58272

metaM man c
is: CHEBI:16024
boundary condition: false
is: HMDB00169
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
name: D-Mannose
initial amount: NaN
is: C00159

metaM arachdcrn x
constant: false
is: HMDB01064
is: http://identifiers.org/pubchem.compound/5462164
type: Species
name: C20:4 carnitine
initial amount: NaN
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_bacd611e_e1f7_48b2_968a_958839083c33
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:80864
is: SBO:0000252
constant: false
name: EGFL8
initial amount: NaN
is: Q99944
initial concentration: NaN

metaM HC00822 e
is: SBO:0000247
is: CHEBI:28681
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
type: Species
name: Chitobiose

http://identifiers.org/biomodels.db/MODEL1310110052#_165b39dc_4ae1_4528_b0cb_a026b9f89abe
is encoded by: hsa:125
name: ADH1B
is: P00325
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252

metaM ppi c
notes: FORMULA: HO7P2 CHARGE: -3
has only substance units: false
is: C00013
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:0
is: SBO:0000247
type: Species
name: Diphosphate
initial amount: NaN
is: HMDB00250

metaR FACOAL241
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
reversible: true
reactant: MODEL1310110052#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110052#
is: SBO:0000176
fast: false

metaM xol7ah2al c
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: CHEBI:27428
is: HMDB06894
initial amount: NaN
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
type: Species
boundary condition: false
constant: false

metaR r1106
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#
name: Postulated transport reaction
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
fast: false
is described by: ECO:0000000

metaR GLNALANaEx
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110052#
is: SBO:0000185
fast: false
reversible: false
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110052#
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)
product: MODEL1310110052#

metaM ura c
is: C00106
is: SBO:0000247
constant: false
name: Uracil
is: CHEBI:17568
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
has only substance units: false
initial amount: NaN
is: HMDB00300

metaR DUDPtn
name: dUDP nuclear transport
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
product: MODEL1310110052#
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110052#_1145c7aa_bbd7_4971_b78a_e6a6c699fcee
constant: false
name: PTDSS1
is encoded by: hsa:9791
has only substance units: false
type: Species
is: P48651
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_934e2883_796e_4bd0_b5cd_06c031e738e7
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q9C0J1
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:79369
name: B3GNT4
constant: false

metaM lgnccoa c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB06526
constant: false
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
type: Species
name: lignocericyl coenzyme A

metaM accoa c
has only substance units: false
initial amount: NaN
is: HMDB01206
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: CHEBI:57288
is: SBO:0000247
constant: false
boundary condition: false
type: Species
name: Acetyl-CoA
is: C00024
initial concentration: 1.0

metaM glac r
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB06355
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
is: SBO:0000247
name: D-glucurono-6,3-lactone
is: CHEBI:18268
has only substance units: false
initial amount: NaN
constant: false

metaM ksii core2 deg1 l
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
boundary condition: false
is: HMDB00868
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57737
constant: false
has only substance units: false
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_e82e952a_e3de_4078_865b_851880929709
name: GALNT3
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2591
boundary condition: true
is: Q14435
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_dc1f9eaa_7f66_468e_ad1e_f825bb88281d
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: ENPP1
is: P22413
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5167

metaM cys L c
name: L-cysteine
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
initial amount: NaN
is: HMDB00574
is: CHEBI:17561
has only substance units: false
constant: false
is: SBO:0000247
type: Species

metaM estrones c
is: HMDB01425
is: CHEBI:60050
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C18H21O5S CHARGE: -1 INCHI: InChI=1S/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/p-1/t14-,15-,16+,18+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00961 EHMN_ABBREVIATION: C02538
name: estrone 3-sulfate(1-)
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_9b05299a_e39a_41e7_b1a2_5966170c7b07
is: P16152
is encoded by: hsa:873
initial amount: NaN
constant: false
is: SBO:0000252
name: CBR1
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_29580bcc_efce_4b41_bec4_1e13bbac1907
is: SBO:0000252
initial amount: NaN
type: Species
name: PANK1
is encoded by: hsa:53354
has only substance units: false
boundary condition: true
constant: false
is: Q8TE04
initial concentration: NaN

metaM ocdca c
is: CHEBI:25629
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
type: Species
initial amount: NaN
name: stearate
has only substance units: false
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
is: HMDB00827

metaM 4mlacac c
name: 4-maleylacetoacetate
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
is: HMDB02052
is: CHEBI:17105

metaM stcoa c
initial amount: NaN
is: C00412
name: Stearoyl-CoA (n-C18:0CoA)
constant: false
is: HMDB01114
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: CHEBI:57394

metaR NACHEX9ly
modifier: MODEL1310110052#
is described by: ECO:0000000
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
reversible: false
kinetic law: MODEL1310110052#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110052#
product: MODEL1310110052#

metaM ksi pre13 g
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: C00130
constant: false
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 13
initial concentration: 1.0
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
is: CHEBI:58053
type: Species
boundary condition: false

metaR C12OHc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdodecanoylcarnitinec
type: Reaction

metaR FUMSO4tm
fast: false
modifier: MODEL1310110052#
name: Fumarate:sulfate antiport, mitochondrial
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
reversible: true
type: Reaction
reactant: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#

metaM m4masn g
is: C05881
initial concentration: 1.0
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false
notes: FORMULA: C46H77N2O35X CHARGE: 0
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
constant: false

metaM fdp c
is: HMDB01058
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
constant: false
boundary condition: false
is: C00354
type: Species
has only substance units: false
name: D-Fructose 1,6-bisphosphate
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3647
is: CHEBI:16905
is: SBO:0000247
initial amount: NaN

metaR HEXDCRNe
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecanoyl carnitine into extra cellular space
type: Reaction

metaR LNLNCAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
is: SBO:0000185
fast: false
kinetic law: MODEL1310110052#
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110052#
product: MODEL1310110052#

metaM h m
has only substance units: false
name: proton
type: Species
is: SBO:0000247
is: C00080
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380

metaR THRGLNNaEx
reversible: false
product: MODEL1310110052#
name: L-threonine/L-glutamine Na-dependent exchange (Thr-L in)
is: SBO:0000185
kinetic law: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

http://identifiers.org/biomodels.db/MODEL1310110052#_d6ec2cc3_f820_40d2_a76d_9edd1fb560a9
type: Species
name: DGKQ
is encoded by: hsa:1609
initial amount: NaN
boundary condition: true
constant: false
is: P52824
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM lald D c
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
is: HMDB06458
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:17167
name: (R)-lactaldehyde
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_d7ff19b7_438e_4f87_b997_f2e31d287350
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:11041
name: B3GNT1
constant: false
is: O43505
type: Species
boundary condition: true

metaM h n
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:24636
has only substance units: false
constant: false
name: proton

metaM leuktrE4 c
type: Species
is: CHEBI:57462
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: leukotriene E4(1-)
initial concentration: 1.0
is: HMDB02200
boundary condition: false
constant: false

metaR GGH 7DHFe
reversible: false
is: SBO:0000176
type: Reaction
name: Gamma-glutamyl hydrolase (7DHF), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
modifier: MODEL1310110052#
fast: false
product: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_8f772ddb_cbc4_45bc_8ce3_95faabb5588d
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaM hco3 c
has only substance units: false
initial amount: NaN
name: Bicarbonate
boundary condition: false
is: CHEBI:17544
is: HMDB00595
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
type: Species
is: C00288

http://identifiers.org/biomodels.db/MODEL1310110052#_fc354d85_e1bf_427c_8033_e9fbdc349976
boundary condition: true
is: SBO:0000252
constant: false
name: PNPLA3
is encoded by: hsa:80339
has only substance units: false
initial concentration: NaN
is: Q9NST1
type: Species
initial amount: NaN

metaR CYTK1n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
fast: false
modifier: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP),nuclear
is: SBO:0000176
is described by: ECO:0000269

metaM retn c
boundary condition: false
type: Species
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: all-trans-retinoate
constant: false
is: HMDB01852
is: CHEBI:35291
initial amount: NaN

metaM HC00342 c
initial amount: NaN
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
is: CHEBI:16383
name: cis-aconitate(3-)
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species

metaM dhcrm hs c
has only substance units: false
name: dihydroceramide
initial amount: NaN
is: CHEBI:31488
initial concentration: 1.0
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
is: SBO:0000247
constant: false
type: Species
boundary condition: false

metaR NACHEXA11ly
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110052#
product: MODEL1310110052#
modifier: MODEL1310110052#
is: SBO:0000176

metaR SIAASE2ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
reactant: MODEL1310110052#
reversible: false
name: sialidase, lysosomal
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaM clpndcoa x
boundary condition: false
is: HMDB06267
is: C16166
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
type: Species
name: clupanodonyl CoA
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205476
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN

metaM ocdca e
is: HMDB00827
is: CHEBI:25629
boundary condition: false
is: C01530
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
type: Species
constant: false
name: octadecanoate (n-C18:0)
is: SBO:0000247

metaM hpdcacrn m
has only substance units: false
initial concentration: 1.0
constant: false
name: heptadecanoyl carnitine
initial amount: NaN
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
is: SBO:0000247
is: HMDB06210
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_0c2447be_423c_48a8_bb17_4a8d52a02bee
type: Species
is: SBO:0000252
name: GPD1
initial amount: NaN
is encoded by: hsa:2819
has only substance units: false
is: F8W1L5
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_524b8890_983f_4330_b17f_ced2382ac88c
boundary condition: true
type: Species
is: Q6IRT1
name: ADH5
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:128
has only substance units: false

metaR ORNTArm
name: ornithine transaminase reversible (m)
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (4942.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.13 Confidence Level: 4 AUTHORS: PMID:9514741 NOTES:kh 1/7/03 SAB m
type: Reaction
product: MODEL1310110052#
modifier: MODEL1310110052#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.13
reversible: true
kinetic law: MODEL1310110052#
is: SBO:0000176

metaM doco13ecoa c
is: SBO:0000247
name: 13-docosenoylcoa
boundary condition: false
constant: false
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892791

http://identifiers.org/biomodels.db/MODEL1310110052#_f8ef51cc_ad18_4eee_bbbd_3bc5eabed303
has only substance units: false
type: Species
is encoded by: hsa:4537
is: P03897
name: ND3
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR r1109
reversible: true
reactant: MODEL1310110052#
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110052#

metaR ELAIDCPT1
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
modifier: MODEL1310110052#
name: carnitine O-palmitoyltransferase
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

metaM nad r
name: NAD(1-)
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
is: SBO:0000247
is: HMDB00902
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: CHEBI:57540
initial concentration: 1.0

metaR r1428
type: Reaction
name: Free diffusion
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
is described by: ECO:0000000

metaM ksi pre28 g
initial concentration: 1.0
is: C00130
name: keratan sulfate I biosynthesis, precursor 28
boundary condition: false
is: HMDB00175
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:58053
constant: false

metaR EX adn LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Adenosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_6e4696de_6d42_43d6_87c4_b7e7d58161ab
is: SBO:0000252
constant: false
type: Species
is: P08237
has only substance units: false
boundary condition: true
is encoded by: hsa:5213
name: PFKM
initial concentration: NaN
initial amount: NaN

metaR ALAGLYexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
is: SBO:0000185
is described by: ECO:0000304
name: L-alanine/glycine reversible exchange
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_46e98d65_c7b0_4064_bbb5_d08b16866ad1
type: Species
is encoded by: hsa:5144
is: SBO:0000252
is: Q08499
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: PDE4D
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_6366e857_da73_414f_b073_72c6d2ca8f0c
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3073
has only substance units: false
initial amount: NaN
is: P06865
initial concentration: NaN
name: HEXA

metaM man g
has only substance units: false
boundary condition: false
is: HMDB00169
name: D-mannose
type: Species
initial amount: NaN
is: CHEBI:16024
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159

http://identifiers.org/biomodels.db/MODEL1310110052#_27d6a9aa_da8c_4a40_a2c3_e844b6058977
name: RDH11
type: Species
constant: false
boundary condition: true
is: B4DDW0
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:51109
is: SBO:0000252

metaR P4507A1r
fast: false
kinetic law: MODEL1310110052#
reversible: false
name: cytochrome P450, family 7, subfamily A, polypeptide 1
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.14.13.17
product: MODEL1310110052#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1581.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.17 Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110052#

metaM HC01412 m
name: trans-tetradec-2-enoyl-CoA(4-)
is: CHEBI:61405
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
constant: false

metaM g3pc c
constant: false
is: HMDB00086
is: SBO:0000247
type: Species
is: CHEBI:16870
name: sn-Glycero-3-phosphocholine
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670
boundary condition: false
has only substance units: false

metaR GPIMTer L
kinetic law: MODEL1310110052#
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
modifier: MODEL1310110052#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
fast: false
is: SBO:0000176

metaM m1mpdol L c
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
is: CHEBI:28067
initial amount: NaN
notes: FORMULA: C1360H2228N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species

metaR r0051
is: SBO:0000176
fast: false
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
reactant: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5

metaM leuktrE4 e
is: SBO:0000247
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
initial amount: NaN
has only substance units: false
is: HMDB02200
name: leukotriene E4(1-)
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: CHEBI:57462

http://identifiers.org/biomodels.db/MODEL1310110052#_3c1c3150_93fc_4e90_b0da_64a0785ccfe8
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:216
has only substance units: false
name: ALDH1A1
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is: P00352

http://identifiers.org/biomodels.db/MODEL1310110052#_d4352c18_c80d_4100_a797_d0e5cc8fb582
is: Q9Y2D0
has only substance units: false
type: Species
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:11238
name: CA5B
is: SBO:0000252

metaR r1429
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110052#
type: Reaction
name: Free diffusion
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reversible: true

metaR ELAIDCPT2
is described by: ECO:0000000
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
modifier: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110052#

metaM hco3 e
initial amount: NaN
has only substance units: false
is: CHEBI:17544
name: Bicarbonate
boundary condition: false
is: HMDB00595
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: C00288
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288

metaR FAOXTC182TC162m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C18:2-->C16:2)m
type: Reaction

metaR FAOXC161C161OHm
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of 3-hydroxyhexadecenoylcoA
type: Reaction

metaR LDH L
is: SBO:0000176
name: L-lactate dehydrogenase
kinetic law: MODEL1310110052#
fast: false
reversible: true
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
type: Reaction
reactant: MODEL1310110052#
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.1.27
is described by: ECO:0000000

metaR ORPT
is version of: http://identifiers.org/ec-code/2.4.2.10
fast: false
name: orotate phosphoribosyltransferase
is described by: ECO:0000269
product: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_350cbfeb_c0dc_4e0d_a779_e496f39d2375
initial amount: NaN
constant: false
is encoded by: hsa:AA576959
name: _AA576959_1_c
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaR C16DCc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexadecanedioylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_ed23b3e4_9929_477d_b282_70c268637f7f
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5373
name: PMM2
is: O15305
initial concentration: NaN
constant: false
has only substance units: false
type: Species

metaM h l
initial concentration: 1.0
is: CHEBI:24636
boundary condition: false
has only substance units: false
name: proton
type: Species
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: "
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
constant: false
is: C00080

metaM 4hglusa m
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
name: L-4-hydroxyglutamic semialdehyde
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:27809
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB06556

metaR FAOXC18280m
is described by: ECO:0000000
kinetic law: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:2, transe -> c8:0 - 5 rounds of beta ox, lose 2 degrees of unsat - only 3 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
reactant: MODEL1310110052#
name: Beta oxidation of fatty acid
type: Reaction
modifier: MODEL1310110052#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR GALASE6ly
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110052#
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
reversible: false
name: beta-galactosidase, lysosomal
fast: false
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110052#_c8db9d53_2989_4d38_9a9a_33bce8285959
is: SBO:0000252
is: Q8IWU9
has only substance units: false
initial amount: NaN
is encoded by: hsa:121278
constant: false
boundary condition: true
name: TPH2
type: Species
initial concentration: NaN

metaM arachd r
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
name: arachidonate
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: HMDB01043
is: SBO:0000247
is: CHEBI:32395
initial concentration: 1.0

metaR FAOXC2242046m
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of long chain fatty acid
reversible: false
is: SBO:0000176
reactant: MODEL1310110052#
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000000

metaM akg e
initial concentration: 1.0
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: HMDB00208
boundary condition: false
name: 2-oxoglutarate(2-)
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
is: CHEBI:16810

metaM tetpent6 c
constant: false
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: tetracosapentaenoic acid, n-6
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
initial amount: NaN
is: HMDB06322

metaR MMSAD3m
is described by: ECO:0000269
modifier: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
type: Reaction
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.27
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
is: SBO:0000176
kinetic law: MODEL1310110052#

metaR EX thymd LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymidine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_3e7b2030_c3ef_4004_b15f_bfd4a40f9372
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6647
is: P00441
initial concentration: NaN
type: Species
boundary condition: true
name: SOD1
constant: false
initial amount: NaN

metaM accoa m
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
boundary condition: false
constant: false
is: HMDB01206
is: SBO:0000247
type: Species
is: CHEBI:57288
is: C00024
name: Acetyl-CoA
initial amount: NaN
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_91061de7_1617_4ea7_8e44_18454f635d95
is encoded by: hsa:23428
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
has part: Q86U05
is: SBO:0000297
constant: false
name: SLC7A8:SLC3A2

metaR DECDPtm
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:ubiquinone precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000185
fast: false
name: lipid, flip-flop intracellular transport
reversible: true
reactant: MODEL1310110052#

metaR DAG HSter
kinetic law: MODEL1310110052#
product: MODEL1310110052#
name: diacylglycerol ER export
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
reversible: false
fast: false
reactant: MODEL1310110052#
type: Reaction

metaR Htg
reactant: MODEL1310110052#
fast: false
name: proton diffusion (Golgi)
product: MODEL1310110052#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110052#
is described by: ECO:0000000
reversible: true

metaR ATPS4m
modifier: MODEL1310110052#
name: ATP synthase (four protons for one ATP)
is version of: http://identifiers.org/ec-code/3.6.4.6
notes: GENE_ASSOCIATION: (513.1 and 498.2 and 506.1 and 509.2 and 514.1 or 498.2 and 513.2 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 514.2 and 506.1 or 498.2 and 513.2 and 506.1 and 509.2 and 514.1 or 513.2 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 498.1 and 506.1 and 509.2 and 514.1 or 513.1 and 498.2 and 514.2 and 506.1 and 509.2 or 513.1 and 498.2 and 509.1 and 506.1 and 514.1 or 498.2 and 509.1 and 513.2 and 506.1 and 514.1 or 513.2 and 498.1 and 506.1 and 509.2 and 514.1 or 513.2 and 514.2 and 506.1 and 509.2 and 498.3 or 513.2 and 506.1 and 509.2 and 498.3 and 514.1 or 513.1 and 509.1 and 506.1 and 498.3 and 514.1 or 509.1 and 513.2 and 514.2 and 506.1 and 498.3 or 513.1 and 498.2 and 509.1 and 514.2 and 506.1 or 513.1 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 506.1 and 514.1 or 513.1 and 506.1 and 509.2 and 498.3 and 514.1 or 509.1 and 513.2 and 506.1 and 498.3 and 514.1 or 513.1 and 514.2 and 506.1 and 509.2 and 498.3 or 509.1 and 513.2 and 498.1 and 506.1 and 514.1 or 513.1 and 509.1 and 514.2 and 506.1 and 498.3 or 498.2 and 509.1 and 513.2 and 514.2 and 506.1 or 509.1 and 513.2 and 498.1 and 514.2 and 506.1) and (10632.1 and 4905.1 and 10476.1 and 9551.3 and 522.5 and 516.2 and 521.1 and 515.1 or 518.3 and 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 9551.3 and 522.3 or 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 517.2 and 9551.2 and 522.3 or 10632.1 and 4905.1 and 10476.1 and 522.5 and 9551.2 and 518.2 and 521.1 and 515.1 or 4905.1 and 515.2 and 10476.2 and 516.2 and 521.1 and 10632.1 and 9551.3 and 522.5 or 518.3 and 4905.1 and 9551.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 522.4 or 10632.1 and 4905.1 and 10476.1 and 9551.1 and 522.2 and 515.2 and 518.2 and 521.1 or 518.3 and 10632.1 and 4905.1 and 10476.1 and 515.3 and 9551.2 and 522.4 and 521.1 or 10632.1 and 4905.1 and 10476.1 and 515.3 and 522.2 and 9551.3 and 518.2 and 521.1 or 4905.1 and 9551.1 and 10476.2 and 522…
is version of: http://identifiers.org/ec-code/3.6.3.14
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.14
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110052#

metaM dcamp c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
is: C03794
is: HMDB00536
is: CHEBI:57567
initial amount: NaN
has only substance units: false
type: Species
name: N6-(1,2-Dicarboxyethyl)-AMP

metaM arachdcrn m
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
name: C20:4 carnitine
is: CHEBI:57387
initial amount: NaN
is: SBO:0000247
is: HMDB01322

metaM accoa n
is: HMDB01206
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
name: acetyl-CoA(4-)
has only substance units: false
is: CHEBI:57288
constant: false
initial concentration: 1.0

metaR S6T4g
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
type: Reaction
product: MODEL1310110052#
modifier: MODEL1310110052#
reversible: false

metaR SRTNtu
kinetic law: MODEL1310110052#
is: SBO:0000185
reactant: MODEL1310110052#
type: Reaction
name: Serotonin uniport
reversible: true
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
fast: false
product: MODEL1310110052#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110052#_378481e8_f979_46ca_91f0_f74454cd881c
type: Species
has only substance units: false
initial concentration: NaN
name: CA2
constant: false
boundary condition: true
initial amount: NaN
is: P00918
is encoded by: hsa:760
is: SBO:0000252

metaR CYSALANaEx
is: SBO:0000185
fast: false
reactant: MODEL1310110052#
name: L-alanine/L-cysteine Na-dependent exchange (Cys-L in)
kinetic law: MODEL1310110052#
reversible: false
modifier: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
type: Reaction

metaM xylt e
has only substance units: false
name: xylitol
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:17151
is: HMDB02917
type: Species

metaR XOL7AH2tm
reversible: true
is: SBO:0000185
name: lipid, flip-flop intracellular transport
type: Reaction
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
product: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#

metaM lpchol hs c
boundary condition: false
name: lysophosphatidylcholine
is: CHEBI:60479
constant: false
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaM ala B e
initial amount: NaN
has only substance units: false
name: beta-alanine
is: SBO:0000247
type: Species
is: HMDB00056
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:16958
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100

metaM estrone c
name: estrone
type: Species
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:17263
notes: FORMULA: C18H22O2 CHARGE: 0 INCHI: InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1 EHMN_ABBREVIATION: C00468
is: HMDB00145
has only substance units: false
is: SBO:0000247

metaM adpcoa x
constant: false
type: Species
initial concentration: 1.0
name: adipoylcoa
is: C14143
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB04047
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
boundary condition: false

metaM dpcoa m
boundary condition: false
is: SBO:0000247
name: 3'-dephospho-CoA(2-)
constant: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
has only substance units: false
initial amount: NaN
type: Species
is: HMDB01373
is: CHEBI:57328
initial concentration: 1.0

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_f38e2922_d411_47c8_95d9_d5c0316b782d
initial amount: NaN
type: Species
name: PDE4A
initial concentration: NaN
is: SBO:0000252
is: P27815
boundary condition: true
constant: false
is encoded by: hsa:5141
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_67a1d67a_e4a4_40f9_a41a_b9a7aedcb209
name: GMPPA
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:29926
is: SBO:0000252
constant: false

metaM ksi pre21 g
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 21
constant: false
is: C00130
is: CHEBI:58053
boundary condition: false
type: Species
is: HMDB00175

metaM bhb m
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: CHEBI:10983
is: HMDB00011
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
name: (R)-3-hydroxybutyrate

metaM tetpent6 e
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
is: HMDB06322
name: tetracosapentaenoic acid, n-6

metaM dolp L r
name: dolichyl phosphate(2-)
initial amount: NaN
is: SBO:0000247
is: CHEBI:57683
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
has only substance units: false
constant: false

metaR FAOXC162C162OHm
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:2-->C16:2OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_4edcab5f_1cc3_4efc_84ec_da977233e339
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:498
boundary condition: true
initial concentration: NaN
type: Species
is: P25705
name: ATP5A1

metaR DMHPTCRNt
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110052#
fast: false
name: 2,6 dimethylheptanoyl crn transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES:dmhptcoa is 'special' because its biochemical fat isn't known NJ
reactant: MODEL1310110052#
reversible: true
type: Reaction
kinetic law: MODEL1310110052#

metaR EX srtn LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Serotonin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_d5179e53_9711_49ed_98ca_483e47e777b2
is encoded by: hsa:56901
is: Q9NRX3
type: Species
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
name: NDUFA4L2
initial concentration: NaN
is: SBO:0000252

metaR 3HKYNAKGAT
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.64
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.6.1.7
is described by: ECO:0000304
is: SBO:0000176
type: Reaction
modifier: MODEL1310110052#
product: MODEL1310110052#
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase

metaM ala B c
boundary condition: false
name: beta-alanine
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00056
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: CHEBI:16958
has only substance units: false
initial concentration: 1.0

metaM lpchol hs e
constant: false
boundary condition: false
name: lysophosphatidylcholine
is: CHEBI:60479
initial concentration: 1.0
type: Species
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM dpcoa l
name: 3'-dephospho-CoA(2-)
initial amount: NaN
is: HMDB01373
has only substance units: false
is: SBO:0000247
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial concentration: 1.0
is: CHEBI:57328
constant: false
type: Species
boundary condition: false

metaM clpndcoa c
has only substance units: false
is: HMDB06267
type: Species
name: clupanodonyl CoA
is: SBO:0000247
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
is: http://identifiers.org/pubchem.compound/47205476
is: C16166
constant: false
initial concentration: 1.0
initial amount: NaN

metaM gacpail hs c
constant: false
type: Species
is: CHEBI:61548
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
is: C00092
name: glucosaminyl-acylphosphatidylinositol
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01401
has only substance units: false

metaM xylt c
boundary condition: false
name: xylitol
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
has only substance units: false
is: CHEBI:17151
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB02917
is: SBO:0000247

metaR GLYBtm
reactant: MODEL1310110052#
type: Reaction
name: Glycine betaine transport via diffusion (mitochondria to cytosol)
kinetic law: MODEL1310110052#
product: MODEL1310110052#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8443213 NOTES:MM
is: SBO:0000185
is described by: ECO:0000000

metaR r0614
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
fast: false
type: Reaction
reversible: true
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
is: SBO:0000176
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000

metaR BTNt4i
name: Biotin uptake (antiport)
kinetic law: MODEL1310110052#
product: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
is: SBO:0000185
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_03e3ace1_8e6f_4af3_a8d0_efe069cd10e5
is encoded by: hsa:8527
is: SBO:0000252
name: DGKD
has only substance units: false
is: Q16760
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
type: Species

metaM tettet6coa x
name: tetracosatetraenoyl coenzyme A
initial amount: NaN
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
is: C16171
is: SBO:0000247
constant: false
is: HMDB06516
is: http://identifiers.org/pubchem.compound/47205481
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_54cd0c89_8304_4931_9a7a_2e39cd210419
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: B2RAU6
is encoded by: hsa:9091
constant: false
type: Species
name: PIGQ

metaM glx m
name: glyoxylate
initial amount: NaN
constant: false
type: Species
is: HMDB00119
is: CHEBI:36655
initial concentration: 1.0
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR UROLACer
name: uronolactonase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.19 Confidence Level: 1 AUTHORS: PMID:13587494 NOTES:NCD
product: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#
fast: false
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110052#_5f5a9c8e_ffd5_4288_ba73_978c8173533f
is: SBO:0000252
initial concentration: NaN
is: E7EPT3
initial amount: NaN
boundary condition: true
type: Species
constant: false
name: ALDH7A1
is encoded by: hsa:501
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_aba1d00f_a4a5_4c12_9017_ed6b30dcdeae
initial amount: NaN
boundary condition: true
type: Species
name: ND4L
is: SBO:0000252
constant: false
is encoded by: hsa:4539
initial concentration: NaN
is: Q7GXZ4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_529cf753_d7fd_4398_8ca2_266e87a822a0
is encoded by: hsa:478
name: ATP1A3:ATP1B1
boundary condition: true
is: SBO:0000297
has only substance units: false
has part: A3KLL5
is encoded by: hsa:481
has part: B7Z2T0
initial amount: NaN
constant: false
type: Species
initial concentration: NaN

metaM CE2433 m
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
type: Species
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
initial amount: NaN
is: CHEBI:57795
has only substance units: false

metaR FAOXC16180m
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000176
fast: false
is described by: ECO:0000269
product: MODEL1310110052#
name: Beta oxidation fatty acid
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR r2100
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000000

metaM 3mob m
is: SBO:0000247
boundary condition: false
name: 3-methyl-2-oxobutanoate
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:11851
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: HMDB00019
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_15003c38_69bb_4f75_8138_c0b760a9065d
is encoded by: hsa:522
name: ATP5J
is: Q6IB54
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN

metaM for c
is: SBO:0000247
type: Species
is: HMDB00142
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: C00058
boundary condition: false
constant: false
is: CHEBI:15740
name: Formate

http://identifiers.org/biomodels.db/MODEL1310110052#_d6b90feb_b30c_4a09_9dac_ab2282af937f
initial amount: NaN
is encoded by: hsa:5264
has only substance units: false
is: O14832
name: PHYH
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial concentration: NaN

metaR GALASE20ly
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
modifier: MODEL1310110052#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110052#_1f50126d_d445_4ce4_8692_77e944cbb7ca
initial amount: NaN
is: SBO:0000252
is: P26439
is encoded by: hsa:3284
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
name: HSD3B2
constant: false

metaR GBA
type: Reaction
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ
kinetic law: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.2.1.45
is: SBO:0000176
product: MODEL1310110052#
fast: false
name: Glucosylceramidase
reversible: false

metaR COt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
reversible: true
kinetic law: MODEL1310110052#
name: CO transporter via diffusion
reactant: MODEL1310110052#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_6c00ac58_5197_4076_996f_6570269a1224
is: Q8WY07
boundary condition: true
name: SLC7A3
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:84889
has only substance units: false
initial amount: NaN

metaR r0616
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
fast: false
kinetic law: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
is: SBO:0000176
reversible: true
reactant: MODEL1310110052#
is described by: ECO:0000000
modifier: MODEL1310110052#
product: MODEL1310110052#

metaR XOLEST2te
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
product: MODEL1310110052#
is: SBO:0000185
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
name: cholesterol ester transporter

http://identifiers.org/biomodels.db/MODEL1310110052#_e663a1d9_5eba_4bb0_9615_2f069757f1b9
is encoded by: hsa:57835
constant: false
name: SLC4A5
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_b228de9f_1d4f_47a3_989b_e95515dc6e07
boundary condition: true
is encoded by: hsa:3030
is encoded by: hsa:3032
is: SBO:0000297
type: Species
has part: P55084
name: HADHA:HADHB
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
has part: E9KL44

metaR r1172
reactant: MODEL1310110052#
reversible: false
product: MODEL1310110052#
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
is described by: ECO:0000000
name: EC:3.1.1.13

metaM bglc e
notes: FORMULA: C1200000H2200000O1100000 CHARGE: 0
name: beta-glucans
is: HMDB00725
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false

metaM CE5788 e
is: CHEBI:27485
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: HMDB02710
initial concentration: 1.0
name: kinetensin 1-7
constant: false
is: SBO:0000247

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

metaM accoa g
has only substance units: false
is: HMDB01206
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: acetyl-CoA(4-)
type: Species
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: CHEBI:57288

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaR r1421
product: MODEL1310110052#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
type: Reaction
reactant: MODEL1310110052#
is: SBO:0000185
name: Free diffusion
kinetic law: MODEL1310110052#

metaM akg c
is: CHEBI:16810
initial amount: NaN
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: SBO:0000247
is: HMDB00208
is: C00026
name: 2-Oxoglutarate
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR 4NPHSFte
is described by: ECO:0000000
product: MODEL1310110052#
type: Reaction
fast: false
reactant: MODEL1310110052#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110052#
name: xenobiotic transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat

metaR AMETt2m
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
modifier: MODEL1310110052#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_0a0c2b4d_1ca1_432a_a9ef_ea76cc1eea0e
has only substance units: false
name: ACSL3
initial concentration: NaN
is encoded by: hsa:2181
is: B3KMA6
boundary condition: true
initial amount: NaN
constant: false
type: Species
is: SBO:0000252

metaM for e
constant: false
initial concentration: 1.0
is: CHEBI:15740
is: SBO:0000247
name: formate
boundary condition: false
type: Species
is: HMDB00142
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
has only substance units: false
initial amount: NaN

metaM chito2pdol L c
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB01196
is: CHEBI:12427
notes: FORMULA: C1240H2028N20O170P20 CHARGE: -20 INCHI: InChI=1S/C41H72N2O17P2/c1-25(2)13-9-14-26(3)15-10-16-27(4)17-11-18-28(5)19-12-20-29(6)21-22-55-61(51,52)60-62(53,54)59-41-35(43-31(8)47)38(50)39(33(24-45)57-41)58-40-34(42-30(7)46)37(49)36(48)32(23-44)56-40/h13,15,17,19,29,32-41,44-45,48-50H,9-12,14,16,18,20-24H2,1-8H3,(H,42,46)(H,43,47)(H,51,52)(H,53,54)/b26-15+,27-17+,28-19-/t29?,32-,33-,34-,35-,36-,37-,38-,39-,40+,41-/m1/s1
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human liver homolog

metaR GLXO2p
kinetic law: MODEL1310110052#
reversible: false
reactant: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (54363.1) or (51179.2) or (51179.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.3.15 Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.3.15
is: SBO:0000176
modifier: MODEL1310110052#
type: Reaction
name: glyoxylate oxidase, peroxisomal
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_1c8bda91_0c0a_4738_9394_c47f7b0e9d98
boundary condition: true
type: Species
constant: false
name: SLC25A18
initial concentration: NaN
is encoded by: hsa:83733
is: Q9H1K4
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_725db553_2bcd_452b_ab41_a324cc817bc1
is: P10619
boundary condition: true
is encoded by: hsa:5476
name: CTSA
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_052094f9_f31e_4f77_b3fe_592961a4526f
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:AA419122
name: _AA419122_1_c

metaR FAOXC102C103m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_633f978f_7f6c_4f34_8a0c_646cf09d099c
has only substance units: false
is encoded by: hsa:129642
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is: Q6ZWT7
name: MBOAT2
initial amount: NaN
initial concentration: NaN

metaR GLUDym
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
modifier: MODEL1310110052#
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110052#
reversible: true
name: glutamate dehydrogenase (NADP), mitochondrial
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.1.3
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#

metaR MG2er
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110052#
reversible: false
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
type: Reaction
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD

metaR CSEPASEly
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110052#
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_45613b8d_1de3_42c1_94a3_786138e14244
constant: false
name: PDE8A
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:5151
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR FRDPtr
is described by: ECO:0000000
product: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
kinetic law: MODEL1310110052#
type: Reaction
fast: false
reversible: true
name: lipid, flip-flop intracellular transport
is: SBO:0000185

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_a5738d8f_f13b_44ce_ab22_5a80508cd2cd
is encoded by: hsa:4720
constant: false
is: B7Z792
name: NDUFS2
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_aee47639_b444_455f_acea_b8346f09c67a
constant: false
has only substance units: false
is encoded by: hsa:6487
initial amount: NaN
boundary condition: true
is: B4DX62
type: Species
initial concentration: NaN
is: SBO:0000252
name: ST3GAL3

metaM ksii core4 l
initial concentration: 1.0
is: CHEBI:17140
boundary condition: false
is: HMDB01644
has only substance units: false
constant: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
is: SBO:0000247
type: Species
initial amount: NaN
name: keratan sulfate II (core 4-linked)

metaM 4abut n
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0
is: C00334
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00112
boundary condition: false
name: 4-Aminobutanoate

metaR MAL Lte
reversible: true
name: Transport of L-malate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110052#
is described by: ECO:0000134
product: MODEL1310110052#
is: SBO:0000185
reactant: MODEL1310110052#
fast: false

metaR PROD2m
reversible: false
product: MODEL1310110052#
is described by: ECO:0000254
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.99.8
name: Proline dehydrogenase (m)
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000176
fast: false

metaR C4tmc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine into mitochondrial matrix
type: Reaction

metaR CITRtm
kinetic law: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110052#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110052#
type: Reaction
name: citrulline mitochondrial transport via proton antiport
product: MODEL1310110052#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_ea2a6923_ba58_4af1_b85f_ac70966b676c
name: HEXB
is: P07686
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:3074

http://identifiers.org/biomodels.db/MODEL1310110052#_1542f8ff_93a8_48e5_87db_b952a49add03
initial concentration: NaN
constant: false
is encoded by: hsa:23533
initial amount: NaN
type: Species
name: PIK3R5
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q8WYR1

metaM n2m2masn g
initial amount: NaN
initial concentration: 1.0
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
has only substance units: false
notes: FORMULA: C50H83N4O35X CHARGE: 0
is: C11530
is: SBO:0000247
constant: false
type: Species
boundary condition: false

metaR PHCHGSm
is: SBO:0000176
reactant: MODEL1310110052#
is described by: ECO:0000000
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
product: MODEL1310110052#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
kinetic law: MODEL1310110052#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110052#_395af829_b0dd_41ec_8774_1011c737b44e
is: SBO:0000252
has only substance units: false
name: NME1
boundary condition: true
is encoded by: hsa:4830
initial amount: NaN
type: Species
constant: false
initial concentration: NaN

metaM pre prot r
notes: FORMULA: XY CHARGE: 0
initial amount: NaN
name: glycophosphatidylinositol (GPI)-anchored protein precursor
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:16240
is: HMDB03125

metaR ALACYSNaEx
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)
type: Reaction
reversible: false
modifier: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110052#
is described by: ECO:0000269
fast: false
is: SBO:0000185

metaM 4abut m
type: Species
initial amount: NaN
is: HMDB00112
boundary condition: false
name: 4-Aminobutanoate
is: CHEBI:16865
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
is: C00334
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR r1846
kinetic law: MODEL1310110052#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110052#
modifier: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: false

metaR O2tn
reversible: true
product: MODEL1310110052#
is: SBO:0000185
name: O2 nuclear transport
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110052#_bcc868c0_acfe_4df3_92f2_e3e4e5a81411
constant: false
boundary condition: true
name: ACSL4
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:2182
type: Species
is: SBO:0000252
is: Q5JWV8

metaR LEUt4
name: L-leucine transport in via sodium symport
notes: GENE_ASSOCIATION: (81539.1) or (84889.1) or (6520.1) or (6542.1) or (6541.1) or (11254.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10391915,PMID:10891391,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:1376926,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
product: MODEL1310110052#
modifier: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
is: SBO:0000185
is described by: ECO:0000269
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_ffb653b8_29e0_4ae7_9185_30340c46a2c6
is: SBO:0000252
name: MTHFD1
initial concentration: NaN
is encoded by: hsa:4522
constant: false
type: Species
is: P11586
has only substance units: false
boundary condition: true
initial amount: NaN

metaM HC01401 m
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:27668
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
name: (S)-3-Hydroxydodecanoyl-CoA
type: Species
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false

metaM s7p c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: Sedoheptulose 7-phosphate
is: C05382
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
type: Species
is: HMDB01068
constant: false
is: CHEBI:57483
boundary condition: false

metaR PAN4PPe
name: PAN4PPe
is described by: ECO:0000134
fast: false
type: Reaction
reactant: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:

metaM dhap e
name: glycerone phosphate(2-)
is: SBO:0000247
is: CHEBI:57642
initial concentration: 1.0
is: HMDB01473
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
constant: false

metaM n2m2mn l
notes: FORMULA: C42H71N3O31 CHARGE: 0
type: Species
is: SBO:0000247
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00742
boundary condition: false
has only substance units: false
is: CHEBI:17588

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR NaKt
is version of: http://identifiers.org/ec-code/3.6.3.9
name: Na+/K+ exchanging ATPase
product: MODEL1310110052#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)
reversible: false
reactant: MODEL1310110052#
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000269
type: Reaction

metaM C02470 c
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
initial amount: NaN
is: HMDB00881
is: C02470
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: Xanthurenic acid
is: http://identifiers.org/pubchem.compound/5485
type: Species
is: SBO:0000247

metaM dpcoa e
boundary condition: false
is: C00882
initial amount: NaN
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
is: CHEBI:57328
has only substance units: false
constant: false
type: Species
is: HMDB01373
initial concentration: 1.0
is: SBO:0000247
name: Dephospho-CoA

metaM ac m
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
type: Species
is: CHEBI:30089
name: acetate
is: HMDB00042

metaM ala B m
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB00056
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
constant: false
is: CHEBI:16958
boundary condition: false
initial amount: NaN
name: beta-alanine

metaR O2tm
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110052#
name: O2 transport (diffusion)
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
is described by: ECO:0000000
type: Reaction
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_ea7b07f5_7a51_409d_bffb_7c777aaab99d
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
name: NME4
has only substance units: false
is: O00746
is encoded by: hsa:4833
initial concentration: NaN
boundary condition: true

metaR 5MTHFt2le
reversible: true
fast: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
product: MODEL1310110052#
reactant: MODEL1310110052#
name: 5-methyltetrahydrofolate transport via anion exchange
is: SBO:0000185
is described by: ECO:0000134

metaR RADH
product: MODEL1310110052#
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#
reversible: true
name: retinal dehydrogenase

metaR COQ5m
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:_2.1.1.- IT
name: Ubiquinone biosynthesis methyltransferase COQ5
is: SBO:0000176
product: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110052#

metaR Htr
reactant: MODEL1310110052#
name: H transporter, endoplasmic reticulum
fast: false
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110052#

metaM m6mpdol L r
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C1660H2728N20O520P20 CHARGE: -20
is: CHEBI:37635
initial concentration: 1.0
initial amount: NaN
type: Species
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog

http://identifiers.org/biomodels.db/MODEL1310110052#_178a9c0c_a1a6_4b19_bea0_95dfad251697
boundary condition: true
is encoded by: hsa:BE966236
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: _BE966236_1_c
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_c38cdd42_71aa_47c6_a6aa_aa4244ddbcdd
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:212
constant: false
is: Q5JZF5
name: ALAS2
boundary condition: true
initial concentration: NaN
type: Species

metaR OXAHCOtex
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000185
type: Reaction
name: oxalate transport via bicarbonate countertransport
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (1836.1) or (10861.1) or (10861.3) or (10861.2) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reversible: false
fast: false
reactant: MODEL1310110052#

metaR r0156
is version of: http://identifiers.org/ec-code/2.7.1.40
kinetic law: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
fast: false
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
product: MODEL1310110052#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
reactant: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction

metaR TYRt
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
kinetic law: MODEL1310110052#
product: MODEL1310110052#
name: L-tyrosine transport
reactant: MODEL1310110052#
is: SBO:0000185
modifier: MODEL1310110052#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000269

metaR AG13T7g
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110052#
product: MODEL1310110052#
modifier: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
reversible: false
type: Reaction

metaM sphmyln hs g
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
name: sphingomyelin betaine
has only substance units: false
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
initial amount: NaN
is: CHEBI:58216
type: Species

metaR RE3001M
is described by: ECO:0000000
name: RE3001
reactant: MODEL1310110052#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.34
product: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
is: SBO:0000176
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#

metaR BACCLm
is version of: http://identifiers.org/ec-code/6.3.4.10
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
modifier: MODEL1310110052#
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
type: Reaction
reversible: false
product: MODEL1310110052#
fast: false
is: SBO:0000176

metaM damp c
constant: false
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
initial concentration: 1.0
is: CHEBI:58245
boundary condition: false
is: HMDB00905
name: dAMP(2-)
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_26b65e6b_699a_439d_a0e1_b41d0ec9de86
name: AGPAT3
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q9NRZ7
is encoded by: hsa:56894
initial amount: NaN
type: Species
constant: false

metaR r0157
is version of: http://identifiers.org/ec-code/6.3.4.2
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
reversible: false
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
fast: false
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_25a4464f_1b24_4121_9146_ae8c01e9a830
initial amount: NaN
is: Q8N5Z0
has only substance units: false
name: AADAT
boundary condition: true
constant: false
is encoded by: hsa:51166
initial concentration: NaN
is: SBO:0000252
type: Species

metaR FAOXC163C143m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:3)m
type: Reaction

metaM dhap c
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57642
boundary condition: false
has only substance units: false
name: Dihydroxyacetone phosphate
is: HMDB01473
is: C00111
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/3411

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaM dpcoa c
has only substance units: false
boundary condition: false
name: Dephospho-CoA
constant: false
is: HMDB01373
is: SBO:0000247
is: CHEBI:57328
type: Species
initial concentration: 1.0
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial amount: NaN
is: C00882

http://identifiers.org/biomodels.db/MODEL1310110052#_5a3f86b5_8ec5_4667_89dc_52d5332c56b6
constant: false
boundary condition: true
name: PIP4K2B
initial concentration: NaN
is encoded by: hsa:8396
type: Species
initial amount: NaN
is: P78356
is: SBO:0000252
has only substance units: false

metaR EX 3octdeccrn
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyoctadecanoyl carnitine
type: Reaction

metaR r0321
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
reversible: false
is: SBO:0000176
modifier: MODEL1310110052#
is described by: ECO:0000000
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
product: MODEL1310110052#
fast: false
is version of: http://identifiers.org/ec-code/6.3.5.2
kinetic law: MODEL1310110052#
type: Reaction

metaR FUMm
product: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
is: SBO:0000176
modifier: MODEL1310110052#
is described by: ECO:0000134
type: Reaction
fast: false
reactant: MODEL1310110052#
reversible: true
name: fumarase, mitochondrial
is version of: http://identifiers.org/ec-code/4.2.1.2

http://identifiers.org/biomodels.db/MODEL1310110052#_e9b31e09_052e_4dec_99fa_1f14f9c60b10
is: SBO:0000252
boundary condition: true
is encoded by: hsa:221823
has only substance units: false
name: PRPS1L1
constant: false
type: Species
initial concentration: NaN
initial amount: NaN

metaM idp e
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
name: IDP(3-)
type: Species
is: SBO:0000247
is: CHEBI:58280
is: HMDB03335

http://identifiers.org/biomodels.db/MODEL1310110052#_0333b02b_5e77_40b0_9d56_bc40bf1328f5
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:AI824319
has only substance units: false
is: SBO:0000252
boundary condition: true
name: _AI824319_1_r

metaM tchola c
initial amount: NaN
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:36257
boundary condition: false
is: HMDB00036
name: taurocholic acid

http://identifiers.org/biomodels.db/MODEL1310110052#_2203b9eb_72fa_43c9_b5c9_8975e4c3d495
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
name: ACAD8
initial concentration: NaN
is encoded by: hsa:27034
is: Q6ZWP6

metaM accoa r
is: SBO:0000247
is: CHEBI:57288
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial amount: NaN
constant: false
has only substance units: false
type: Species
name: acetyl-CoA(4-)
boundary condition: false
is: HMDB01206

metaM Sfglutth c
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
is: CHEBI:57688
is: SBO:0000247
name: S-formylglutathionate(1-)
is: HMDB01550

metaR MGCHrm
kinetic law: MODEL1310110052#
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
modifier: MODEL1310110052#
is described by: ECO:0000269
product: MODEL1310110052#
type: Reaction
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.18
is: SBO:0000176
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110052#_4bcb3e76_1cb1_4f53_9172_386f43667cb4
has only substance units: false
is: G3V0F6
initial concentration: NaN
constant: false
initial amount: NaN
name: DGKZ
boundary condition: true
is encoded by: hsa:8525
is: SBO:0000252
type: Species

metaM ksi deg5 l
name: keratan sulfate I, degradation product 5
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
is: HMDB00143
constant: false
is: SBO:0000247
is: CHEBI:12936
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_cd97f56c_000d_4a81_a3de_eca492c144ac
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:100287639
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: _100287639_1_c
boundary condition: true

metaM glx x
name: glyoxylate
initial concentration: 1.0
is: HMDB00119
is: CHEBI:36655
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false

metaM retn r
has only substance units: false
name: all-trans-retinoate
type: Species
is: SBO:0000247
is: CHEBI:35291
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
constant: false
is: HMDB01852
initial concentration: 1.0
boundary condition: false

metaR CSNAT3x
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.7
name: carnitine O-aceyltransferase, peroxisomal
reversible: true
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:7654220,PMID:7829107 NOTES:NJ
fast: false
type: Reaction
modifier: MODEL1310110052#
product: MODEL1310110052#

metaR NRPPHRtu
type: Reaction
is: SBO:0000185
modifier: MODEL1310110052#
reversible: true
product: MODEL1310110052#
fast: false
name: Norepinephrine uniport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_77081964_df36_4eab_8e57_3da0d9f0f876
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is: P04179
name: SOD2
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6648

metaR DHEASULT
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.8.2.4
fast: false
name: Dehydroepiandrosterone sulfotransferase
is described by: ECO:0000269
product: MODEL1310110052#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.8.2.14
notes: GENE_ASSOCIATION: (6783.1) or (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:1588921 NOTES:NJ
type: Reaction
reactant: MODEL1310110052#

metaM idp c
is: HMDB03335
constant: false
name: IDP(3-)
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58280
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial amount: NaN
boundary condition: false
has only substance units: false

metaM arachd x
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
name: arachidonate
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: SBO:0000247
is: HMDB01043
is: CHEBI:32395
initial amount: NaN

metaR DNDPt8m
name: dADP transport via dUDP antiport
is described by: ECO:0000269
reactant: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
type: Reaction
kinetic law: MODEL1310110052#
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110052#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110052#_90032f77_b345_4ca9_bd23_5b5d77fdd504
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q9NY65
name: EHHADH
is: SBO:0000252
is encoded by: hsa:1962
type: Species
constant: false

metaM ksii core4 g
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
is: CHEBI:17140
name: keratan sulfate II (core 4-linked)
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
is: HMDB01644

metaM 12ppd R c
is: HMDB01881
is: CHEBI:28972
has only substance units: false
type: Species
is: SBO:0000247
name: (R)-propane-1,2-diol
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
initial concentration: 1.0

metaM c226coa x
type: Species
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205479
constant: false
initial amount: NaN
name: cervonyl coenzyme A
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
is: C16169

http://identifiers.org/biomodels.db/MODEL1310110052#_01268b41_cec9_4626_ba57_c72afdb6307e
initial concentration: NaN
is: O75947
is: SBO:0000252
name: ATP5H
initial amount: NaN
boundary condition: true
is encoded by: hsa:10476
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_e11f7dbd_2289_4034_a024_939f278d4227
is: Q8TCD5
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:30833
initial concentration: NaN
name: NT5C
type: Species
boundary condition: true
initial amount: NaN

metaM cdpea c
notes: FORMULA: C11H19N4O11P2 CHARGE: -1 INCHI: InChI=1S/C11H20N4O11P2/c12-2-4-23-27(19,20)26-28(21,22)24-5-6-8(16)9(17)10(25-6)15-3-1-7(13)14-11(15)18/h1,3,6,8-10,16-17H,2,4-5,12H2,(H,19,20)(H,21,22)(H2,13,14,18)/p-1/t6-,8-,9-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00433 EHMN_ABBREVIATION: C00570
is: SBO:0000247
is: HMDB01564
constant: false
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:57876
initial concentration: 1.0
initial amount: NaN
name: cdpea[c]

metaR 5ADTSTSTERONESte
reactant: MODEL1310110052#
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110052#
reversible: true
name: sulfonated testosterone transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
product: MODEL1310110052#
type: Reaction

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaM arachdcrn c
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
constant: false
is: HMDB01322
type: Species
initial concentration: 1.0
is: SBO:0000247
name: C20:4 carnitine
has only substance units: false
boundary condition: false
is: CHEBI:57387
initial amount: NaN

metaR O2tp
is: SBO:0000185
reversible: true
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: O2 transport, peroxisomal
is described by: ECO:0000000
reactant: MODEL1310110052#
fast: false
type: Reaction
kinetic law: MODEL1310110052#

metaM sphmyln hs c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
constant: false
has only substance units: false
type: Species
name: sphingomyelin betaine
is: SBO:0000247
is: CHEBI:58216

http://identifiers.org/biomodels.db/MODEL1310110052#_d88e677b_50fc_407a_bde8_5e961f483385
initial amount: NaN
is encoded by: hsa:6487
constant: false
name: ST3GAL3
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_b760b6a0_1917_4e4c_8d45_fa2e5c74926b
boundary condition: true
name: UROD
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P06132
constant: false
type: Species
is encoded by: hsa:7389

http://identifiers.org/biomodels.db/MODEL1310110052#_32ce8d8d_e8ef_4f70_b631_1109ff16e52d
name: INPP5B
is encoded by: hsa:3633
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is: P32019
has only substance units: false
initial amount: NaN
boundary condition: true

metaM gly c
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:3339
initial concentration: 1.0
name: Glycine
notes: FORMULA: C2H5NO2 CHARGE: 0
is: C00037
is: HMDB00123
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_d5f92ff0_95f8_49dd_8cfd_25e52d49a453
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:8818
constant: false
name: DPM2
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR TTDCAtr
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
kinetic law: MODEL1310110052#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110052#
is: SBO:0000185
name: tetradecanoate (transport)
product: MODEL1310110052#
reversible: true

metaR PE HStm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
reversible: true
fast: false
type: Reaction
product: MODEL1310110052#
name: phosphatidylethanolamine scramblase
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110052#_cde39bcb_f276_4d98_a136_5fbecf4aabcc
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q14376
initial concentration: NaN
constant: false
is encoded by: hsa:2582
type: Species
has only substance units: false
name: GALE

metaM nadh r
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
name: NADH(2-)
is: CHEBI:57945
is: HMDB01487
initial amount: NaN
type: Species
has only substance units: false

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR DHPM1
reversible: false
kinetic law: MODEL1310110052#
type: Reaction
modifier: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
is version of: http://identifiers.org/ec-code/3.5.2.2
reactant: MODEL1310110052#
is described by: ECO:0000269
name: dihydropyrimidinase (5,6-dihydrouracil)
fast: false

metaM 3hodcoa c
has only substance units: false
initial concentration: 1.0
name: (S)-3-Hydroxyoctadecanoyl-CoA
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
boundary condition: false
initial amount: NaN
is: HMDB13336
is: SBO:0000247
constant: false
type: Species

metaR CYSGLTH
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
reactant: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000176
name: Glutathione:cystine oxidoreductase

metaM acnam l
is: CHEBI:35418
has only substance units: false
name: N-acetylneuraminate
is: HMDB00230
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270

metaR r1549
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110052#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110052#
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_bcaf46fd_8e19_4e0c_bb75_519ab428305e
type: Species
is: SBO:0000252
name: PYCR1
has only substance units: false
constant: false
is: P32322
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5831

http://identifiers.org/biomodels.db/MODEL1310110052#_b26d662b_feca_470d_89cf_b0e9fb3495e3
is encoded by: hsa:51301
name: GCNT4
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: Q9P109
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_c9608b19_2a55_4da0_b1ea_93ef75253ddd
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: ABCD1
is: P33897
type: Species
constant: false
is encoded by: hsa:215

metaM 4mop c
is: HMDB00695
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
name: 4-methyl-2-oxopentanoate
constant: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
boundary condition: false
is: CHEBI:17865

metaR DNDPt35m
is: SBO:0000185
name: dGDP transport via dADP antiport
is described by: ECO:0000269
modifier: MODEL1310110052#
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
type: Reaction
reversible: false

metaR VACCCRNt
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110052#
modifier: MODEL1310110052#
reversible: false
name: transport into the mitochondria (carnitine)
type: Reaction
product: MODEL1310110052#
fast: false

metaM 3thexddcoacrn e
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB02014
has only substance units: false
constant: false
notes: FORMULA: C23H41NO5 CHARGE: 0
boundary condition: false
initial concentration: 1.0

metaR TYRCBOX
kinetic law: MODEL1310110052#
is described by: ECO:0000134
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
name: L-Tyrosine carboxy-lyase
product: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.28
modifier: MODEL1310110052#
reactant: MODEL1310110052#
fast: false

metaM vacccoa m
is: http://identifiers.org/pubchem.compound/9543677
type: Species
is: SBO:0000247
is: HMDB06521
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
name: vaccenyl coenzyme A
boundary condition: false

metaR r2109
fast: false
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110052#
is: SBO:0000185
product: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110052#

metaR PSFLIPm
name: phosphatidylserine flippase
reversible: false
kinetic law: MODEL1310110052#
is described by: ECO:0000269
product: MODEL1310110052#
modifier: MODEL1310110052#
is: SBO:0000185
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.3.1
fast: false
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_db8f7164_f853_4ac1_8157_43552efe236a
boundary condition: true
constant: false
name: MAN2A1
is: Q16706
is: SBO:0000252
is encoded by: hsa:4124
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

metaR LNLCt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: Linoleic acid (n-C18:2) transport in via diffusion
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000000
fast: false
product: MODEL1310110052#
type: Reaction
reversible: true

metaM 4abut e
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00112
type: Species
is: C00334
notes: FORMULA: C4H9NO2 CHARGE: 0
is: SBO:0000247
name: 4-Aminobutanoate
is: CHEBI:3628
has only substance units: false
constant: false

metaM Lkynr c
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
type: Species
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
is: HMDB00684
is: CHEBI:16946
name: L-kynurenine
initial concentration: 1.0

metaR r0170
product: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110052#
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.1.40
is described by: ECO:0000000
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21

metaR r1705
name: Y+LAT2 Utilized transport
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: false
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_6de61a19_cdca_4dc6_b11b_bfc5270db7eb
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
constant: false
is: P18859
name: ATP5J
is encoded by: hsa:522
is: SBO:0000252
has only substance units: false

metaM pail34p hs n
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
is: CHEBI:57658
has only substance units: false
is: SBO:0000247

metaR PRO Dtde
product: MODEL1310110052#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
kinetic law: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
is described by: ECO:0000134
name: D-proline transport, extracellular
reversible: true

metaM clpnd e
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: HMDB06528
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
name: clupanodonic acid
initial concentration: 1.0
is: CHEBI:53488

http://identifiers.org/biomodels.db/MODEL1310110052#_2b5e0773_6a8d_404a_b8c7_84fe08aad370
is: O95477
constant: false
is encoded by: hsa:19
name: ABCA1
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaR G14T18g
is: SBO:0000176
fast: false
reversible: false
product: MODEL1310110052#
is described by: ECO:0000000
modifier: MODEL1310110052#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_fd2068af_021a_46f8_96b3_32350075e108
is: SBO:0000252
is: O75414
initial concentration: NaN
constant: false
initial amount: NaN
name: NME6
is encoded by: hsa:10201
boundary condition: true
type: Species
has only substance units: false

metaR NACHEXA9ly
modifier: MODEL1310110052#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
reactant: MODEL1310110052#
name: beta-N-acetylhexosaminidase A, lysosomal
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
kinetic law: MODEL1310110052#
product: MODEL1310110052#

metaR OAADC
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: oxaloacetate decarboxylase
type: Reaction

metaM amp m
initial concentration: 1.0
is: SBO:0000247
is: HMDB00045
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: CHEBI:456215
has only substance units: false
name: AMP(2-)
constant: false
initial amount: NaN
type: Species

metaR EX tetdec2crn
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_3b11adc7_6397_4521_b2a1_ef07a2da2f82
type: Species
initial concentration: NaN
name: SLC6A9
is: B7Z3W8
boundary condition: true
constant: false
is encoded by: hsa:6536
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_982423cd_91d1_46e8_9fa4_8bd4882ea5d6
boundary condition: true
name: UAP1L1
is: Q3KQV9
is encoded by: hsa:91373
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_17f8ede4_ecba_47f9_9238_f4911356b025
name: ATP5G1
has only substance units: false
is encoded by: hsa:516
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q6FIH7
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_bdf0dc9a_7581_453d_b2c5_06c4b2721462
has only substance units: false
is: Q9NSW9
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:6553
name: SLC9A5

http://identifiers.org/biomodels.db/MODEL1310110052#_8b084d07_6713_49f6_8fb9_9423b9ccf32c
initial amount: NaN
boundary condition: true
constant: false
name: CHST5
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:23563
is: Q9GZS9
has only substance units: false

metaM aprgstrn c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042
name: (20S)-20-hydroxypregn-4-en-3-one
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:28453
boundary condition: false
is: HMDB03069

http://identifiers.org/biomodels.db/MODEL1310110052#_e96891e3_6efe_441e_ad2a_c89855555c28
boundary condition: true
name: _M68895_1_c
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:M68895
initial concentration: NaN

metaR FAOXC180
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reactant: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false

metaR EX succ LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Succinate exchange
type: Reaction

metaM CE4792 m
initial concentration: 1.0
constant: false
name: 3-oxo-cis-8-tetradecenoyl-CoA
is: SBO:0000247
is: CHEBI:57923
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN

metaM 4abut c
constant: false
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0
is: HMDB00112
name: 4-Aminobutanoate
is: C00334
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:3628
initial concentration: 1.0

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_51e123f2_9e8d_4a6b_8429_52389bdcc8b7
initial amount: NaN
initial concentration: NaN
name: HK1
boundary condition: true
is encoded by: hsa:3098
constant: false
type: Species
has only substance units: false
is: P19367
is: SBO:0000252

metaM clpnd c
constant: false
type: Species
is: HMDB06528
initial concentration: 1.0
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:53488
name: clupanodonic acid

metaM glgchlo e
constant: false
has only substance units: false
notes: FORMULA: C1200026H2200043NO1100006 CHARGE: 0
is: HMDB00725
type: Species
initial concentration: 1.0
name: beta glucan-glycocholate complex
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_c6a53bd1_bc96_47e1_8180_7de6d9f113c9
initial amount: NaN
type: Species
name: DPYSL3
is encoded by: hsa:1809
is: Q8IXW6
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

metaM cholate c
initial amount: NaN
is: HMDB00619
has only substance units: false
boundary condition: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
initial concentration: 1.0
is: CHEBI:29747
constant: false
is: SBO:0000247
name: Cholate
type: Species

metaR KCC2t
is: SBO:0000185
modifier: MODEL1310110052#
reversible: true
name: K+-Cl- cotransporter (NH4+)
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
product: MODEL1310110052#
fast: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#

metaR BETALDHxm
kinetic law: MODEL1310110052#
is: SBO:0000176
fast: false
reactant: MODEL1310110052#
name: betaine-aldehyde dehydrogenase, mitochondrial
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 2 AUTHORS: PMID:15321791 NOTES:MM
is described by: ECO:0000000
product: MODEL1310110052#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_afbc4c94_4c23_4ab3_bd0a_b5c32ce6a9d2
is encoded by: hsa:410
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: P15289
name: ARSA
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM pchol hs e
initial amount: NaN
name: Phosphatidylcholine
has only substance units: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: CHEBI:16110
boundary condition: false

metaM nadh m
is: C00004
name: Nicotinamide adenine dinucleotide - reduced
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/3306
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB01487
is: CHEBI:57945
type: Species

metaM aprgstrn e
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042
has only substance units: false
boundary condition: false
name: (20S)-20-hydroxypregn-4-en-3-one
is: SBO:0000247
is: HMDB03069
is: CHEBI:28453
type: Species
constant: false

metaR GCALDD
product: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110052#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
reversible: false
is described by: ECO:0000304
reactant: MODEL1310110052#
name: Glycolaldehyde dehydrogenase

http://identifiers.org/biomodels.db/MODEL1310110052#_91a4f1ff_0f30_406c_8036_9dad68744913
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is: Q8IWX5
is encoded by: hsa:130367
name: SGPP2
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_a09f0795_7b0e_40b2_a9b4_36ed770030b2
is: SBO:0000252
type: Species
is: Q9HCQ5
boundary condition: true
has only substance units: false
name: GALNT9
initial concentration: NaN
is encoded by: hsa:50614
constant: false
initial amount: NaN

metaR r0463
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
reversible: true
is described by: ECO:0000000
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
kinetic law: MODEL1310110052#
product: MODEL1310110052#
fast: false
type: Reaction
reactant: MODEL1310110052#
is: SBO:0000176

metaM gly e
is: HMDB00123
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:3339
boundary condition: false
initial concentration: 1.0
is: C00037
name: Glycine
type: Species
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110052#_3ac5faa1_7998_4ed9_8ec3_dab58aa8e4ed
has only substance units: false
type: Species
boundary condition: true
name: OXSM
is: SBO:0000252
initial amount: NaN
is: Q9NWU1
initial concentration: NaN
is encoded by: hsa:54995
constant: false

metaR FAOXC121C10x
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_c7af36bd_6552_4bbf_ae8a_b90f22713075
initial concentration: NaN
is: Q7Z725
constant: false
name: SLC34A1
has only substance units: false
is encoded by: hsa:6569
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM gluside hs c
initial concentration: 1.0
has only substance units: false
name: D-glucosyl-N-acylsphingosine
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:18368
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
boundary condition: false

metaM ksi pre1 g
has only substance units: false
initial concentration: 1.0
is: CHEBI:58053
type: Species
is: HMDB00175
notes: FORMULA: C79H129N5O57X CHARGE: -1
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 1
is: C00130

metaM cholate e
name: Cholate
has only substance units: false
boundary condition: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
constant: false
initial concentration: 1.0
is: CHEBI:29747
is: SBO:0000247
initial amount: NaN
is: HMDB00619
type: Species

metaR r0173
is: SBO:0000176
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.6.1.19
reversible: true
reactant: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (3704.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:12042361,PMID:17045662,PMID:7449128,PMID:9927705 NOTES:
name: (S)-Lactate:NAD+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.1.1.27

http://identifiers.org/biomodels.db/MODEL1310110052#_df01181c_3ac0_4d62_b62e_d890b15fc8bc
initial amount: NaN
is: SBO:0000252
constant: false
name: SLCO2A1
is encoded by: hsa:6578
is: Q92959
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species

metaM c226coa m
has only substance units: false
boundary condition: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
constant: false
initial amount: NaN
is: SBO:0000247
is: C16169
is: http://identifiers.org/pubchem.compound/47205479
name: cervonyl coenzyme A
initial concentration: 1.0
type: Species

metaM 3thexddcoacrn c
is: SBO:0000247
has only substance units: false
is: HMDB02014
initial amount: NaN
notes: FORMULA: C23H41NO5 CHARGE: 0
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine

metaR FUCASEe
fast: false
product: MODEL1310110052#
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.2.1.51
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110052#
reversible: false
kinetic law: MODEL1310110052#
name: alpha-fucosidase, extracellular

metaR r0317
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
type: Reaction
fast: false
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.8.1.4
reversible: true
is version of: http://identifiers.org/ec-code/2.1.2.10
reactant: MODEL1310110052#
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
is: SBO:0000176
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.4.4.2
kinetic law: MODEL1310110052#

metaM 4mop e
is: HMDB00695
constant: false
is: CHEBI:17865
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
initial concentration: 1.0
type: Species
name: 4-methyl-2-oxopentanoate
boundary condition: false
is: SBO:0000247

metaR FUMSO3tm
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110052#
fast: false
is: SBO:0000185
name: Fumarate:sulfite antiport, mitochondrial
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110052#
modifier: MODEL1310110052#
reversible: true

metaR DITPtn
product: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#
reversible: true
name: dITP nuclear transport
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
fast: false
type: Reaction

metaM ksi pre27 g
is: C00130
is: SBO:0000247
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
name: keratan sulfate I biosynthesis, precursor 27
has only substance units: false
initial concentration: 1.0
is: CHEBI:58053
type: Species
is: HMDB00175
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_33a2cfcb_29bf_4733_b0bf_a173fc4815a0
has only substance units: false
type: Species
is: Q16836
boundary condition: true
constant: false
is: SBO:0000252
name: HADH
initial amount: NaN
is encoded by: hsa:3033
initial concentration: NaN

metaM 2dr5p c
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
constant: false
boundary condition: false
initial amount: NaN
name: 2-deoxy-D-ribose 5-phosphate(2-)
initial concentration: 1.0
is: HMDB01031
is: CHEBI:57651
has only substance units: false
type: Species
is: SBO:0000247

metaM amp r
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
has only substance units: false
is: C00020
is: CHEBI:456215
is: HMDB00045
constant: false
name: AMP
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false

metaM ksi deg11 l
name: keratan sulfate I, degradation product 11
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
initial amount: NaN
has only substance units: false
is: HMDB00143
constant: false
initial concentration: 1.0
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110052#_48f3a18e_fd1b_48c3_8ba9_6b577043ec3b
initial amount: NaN
name: NME1
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:4830

metaR r2102
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
fast: false
product: MODEL1310110052#
kinetic law: MODEL1310110052#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185

metaR GCHOLAte
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110052#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110052#
name: bile acid intracellular transport
type: Reaction

metaM c12dc x
notes: FORMULA: C19H34NO6 CHARGE: -1
initial amount: NaN
name: dodecanedioyl carnitine
is: HMDB03952
type: Species
initial concentration: 1.0
boundary condition: false
is: C05280
is: SBO:0000247
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_3b831f85_a8a1_4226_931e_c7adeb286034
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaM bhb e
is: HMDB00011
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
name: (R)-3-hydroxybutyrate
is: CHEBI:10983
constant: false
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089

metaM 5mthf c
is: C00440
is: SBO:0000247
boundary condition: false
is: HMDB01396
name: 5-Methyltetrahydrofolate
is: CHEBI:3729
type: Species
initial concentration: 1.0
notes: FORMULA: C20H24N7O6 CHARGE: -1
initial amount: NaN
has only substance units: false
constant: false

metaR ASNCYSNaEx
type: Reaction
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110052#
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
is: SBO:0000185
product: MODEL1310110052#
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaR DCSPTN1CPT2
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110052#
type: Reaction
modifier: MODEL1310110052#
is: SBO:0000176
reactant: MODEL1310110052#
product: MODEL1310110052#
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR r2101
fast: false
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110052#
reversible: true
is: SBO:0000185
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM Ser Gly Ala X Gly l
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
is: CHEBI:36005
is: HMDB02183
constant: false
has only substance units: false
is: SBO:0000247
name: protein-linked serine residue (glycosaminoglycan attachment site)
type: Species
boundary condition: false
initial concentration: 1.0

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaM dopa c
initial amount: NaN
is: SBO:0000247
name: dopaminium(1+)
has only substance units: false
constant: false
boundary condition: false
is: HMDB00073
initial concentration: 1.0
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
type: Species
is: CHEBI:59905

http://identifiers.org/biomodels.db/MODEL1310110052#_cc8e9b29_99fe_47f6_a159_1a1164b00a06
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
constant: false
name: RFK
is: SBO:0000252
is: B2RDZ2
initial concentration: NaN
is encoded by: hsa:55312

http://identifiers.org/biomodels.db/MODEL1310110052#_c88096a3_5928_4647_8fc6_9cfb410cef56
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is: Q16774
name: GUK1
is: SBO:0000252
constant: false
is encoded by: hsa:2987

metaR r0464
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110052#
fast: false
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110052#

metaM C05280 m
is: HMDB03952
has only substance units: false
is: CHEBI:28002
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: cis,cis-3,6-Dodecadienoyl-CoA
constant: false

metaM eicostetcoa c
initial amount: NaN
constant: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
name: eicosatetranoyl coenzyme A
is: SBO:0000247
type: Species
is: C16164
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM nadh x
is: C00004
boundary condition: false
has only substance units: false
is: CHEBI:57945
is: SBO:0000247
type: Species
name: Nicotinamide adenine dinucleotide - reduced
is: HMDB01487
is: http://identifiers.org/pubchem.compound/3306
initial amount: NaN
initial concentration: 1.0
constant: false

metaR DCSPTN1CPT1
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reversible: false
is described by: ECO:0000269
is: SBO:0000176
fast: false
name: carnitine O-palmitoyltransferase
reactant: MODEL1310110052#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_ba6a78c0_00c5_469a_9bd6_f661357b0a19
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:8790
initial amount: NaN
is: O14772
has only substance units: false
is: SBO:0000252
name: FPGT
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_035586d7_de15_443d_8153_2e2cfb95b56a
has only substance units: false
type: Species
is: P39877
initial concentration: NaN
name: PLA2G5
is: SBO:0000252
is encoded by: hsa:5322
constant: false
boundary condition: true
initial amount: NaN

metaR r2104
reactant: MODEL1310110052#
reversible: true
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

metaM gluside hs g
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial amount: NaN
is: CHEBI:18368
initial concentration: 1.0
constant: false
name: D-glucosyl-N-acylsphingosine
has only substance units: false

metaM bhb c
constant: false
boundary condition: false
is: HMDB00011
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: (R)-3-hydroxybutyrate
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
initial concentration: 1.0
is: CHEBI:10983

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaM 5mthf e
constant: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:3729
is: HMDB01396
boundary condition: false
type: Species
name: 5-Methyltetrahydrofolate
is: C00440

metaR THCHOLSTOICtm
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
kinetic law: MODEL1310110052#
name: lipid, flip-flop intracellular transport
is: SBO:0000185
reactant: MODEL1310110052#
reversible: true
product: MODEL1310110052#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_6b258550_dbe2_4001_b9fb_0feeaf41b6a8
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: O60760
name: HPGDS
boundary condition: true
is encoded by: hsa:27306
type: Species
is: SBO:0000252
constant: false

metaR URIDK2m
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: true
is described by: ECO:0000134
fast: false
is: SBO:0000176
name: uridylate kinase (dUMP), mitochondrial
type: Reaction

metaM occoa c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB01070
is: C01944
constant: false
type: Species
is: CHEBI:57386
has only substance units: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
name: Octanoyl-CoA (n-C8:0CoA)

metaM dopa e
constant: false
name: dopaminium(1+)
has only substance units: false
is: HMDB00073
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:59905
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
initial amount: NaN
is: SBO:0000247

metaR r2103
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
modifier: MODEL1310110052#
reactant: MODEL1310110052#

metaM mi134p c
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
boundary condition: false
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
constant: false
type: Species
initial amount: NaN
is: HMDB01143
has only substance units: false
is: CHEBI:58414

metaR sink octdececoa LPAREN c RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: OCTDECECOASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_090567e4_45a0_4916_9aed_b998d01ca89c
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
is: P78381
is encoded by: hsa:7355
initial amount: NaN
has only substance units: false
name: SLC35A2

metaM pchol hs c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
is: CHEBI:16110
name: Phosphatidylcholine
initial amount: NaN

metaR THRGLYexR
fast: false
reactant: MODEL1310110052#
is: SBO:0000185
name: L-threonine/glycine reversible exchange
is described by: ECO:0000304
product: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
reversible: true
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaR TETPENT3t
product: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion

metaR UMPK2n
kinetic law: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reversible: true
modifier: MODEL1310110052#
name: UMP kinase (CTP),nuclear
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110052#_64939560_af45_464f_b233_fd8646cfb07d
constant: false
has only substance units: false
type: Species
name: SLC24A2
is: SBO:0000252
boundary condition: true
is encoded by: hsa:25769
is: Q9UI40
initial concentration: NaN
initial amount: NaN

metaM C04849 e
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
constant: false
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:57449
initial amount: NaN

metaM etoh c
is: HMDB00108
constant: false
type: Species
is: SBO:0000247
name: ethanol
initial concentration: 1.0
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
initial amount: NaN
is: CHEBI:16236
has only substance units: false
boundary condition: false

metaR r2106
type: Reaction
modifier: MODEL1310110052#
product: MODEL1310110052#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110052#_4ee7b655_7697_4112_bd22_c52cec9c785c
is: Q5MY95
is encoded by: hsa:377841
has only substance units: false
name: ENTPD8
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_410bc447_24e3_4ee0_b96b_541790d3b576
type: Species
is encoded by: hsa:3036
constant: false
is: Q8IYH3
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: HAS1

metaR 4HOXPACDOX NADP
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
fast: false
product: MODEL1310110052#
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
reversible: true
is described by: ECO:0000304
modifier: MODEL1310110052#
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
kinetic law: MODEL1310110052#
type: Reaction

metaR ELAIDt
is: SBO:0000185
kinetic law: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110052#
name: fatty acid transport via diffusion
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_830eb72c_5452_4d19_8abc_634079291e0a
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:8897
name: MTMR3
is: SBO:0000252
boundary condition: true

metaR r0750
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
fast: false
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
modifier: MODEL1310110052#
reactant: MODEL1310110052#
product: MODEL1310110052#

metaR GLYtm
product: MODEL1310110052#
name: glycine passive transport to mitochondria
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
type: Reaction
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
is described by: ECO:0000000

metaR RE1796R
product: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.145
name: RE1796
kinetic law: MODEL1310110052#
fast: false
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
reversible: true

metaM ptrc c
initial amount: NaN
initial concentration: 1.0
is: HMDB01414
is: C00134
name: Putrescine
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:326268
boundary condition: false
type: Species
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134

metaR r2105
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
modifier: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_96fbc868_ab14_406d_9e02_90b3e493fb77
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
name: NPR2
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4882

metaM adpcoa c
boundary condition: false
name: adipoylcoa
is: C14143
has only substance units: false
constant: false
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
is: HMDB04047
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR ACNAMtn
product: MODEL1310110052#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
name: N-acetylneuraminate nuclear import
reversible: false

metaM g2m8masn r
type: Species
has only substance units: false
constant: false
is: C05874
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C82H137N2O65X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110052#_d1c31a87_33a0_44d7_be8a_3d74bea02b16
is: F5H6D0
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:7841
name: MOGS
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_40545b7a_30ae_4ce9_8487_287c01830c8f
initial amount: NaN
is encoded by: hsa:6576
is: D9HTE9
boundary condition: true
name: SLC25A1
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_95beb34b_37fa_4fd8_a6be_958cfa34cf48
name: MAN1B1
is: Q9UKM7
constant: false
is encoded by: hsa:11253
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR DM gpi sig er
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_f18f67f7_eeed_421d_a908_1c0e60700317
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: A6NED0
is: SBO:0000252
name: GSTZ1
initial concentration: NaN
constant: false
is encoded by: hsa:2954

metaR FCOAH
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000000
name: formyl coa hydrolase
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11341778,PMID:11591435 NOTES:Note - formcoa formula is uncharged - the correct is FACOAH2 w/ forcoa NJ
reactant: MODEL1310110052#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110052#_cccf1369_3035_4189_a18c_7e0a02eb3573
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: GOT2
boundary condition: true
is: P00505
initial amount: NaN
constant: false
is encoded by: hsa:2806

metaR GPIAT
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
reactant: MODEL1310110052#
reversible: false
is: SBO:0000176
name: glucosaminylphosphatidyl inositol acetyltransferase
is described by: ECO:0000269
fast: false
modifier: MODEL1310110052#
type: Reaction
product: MODEL1310110052#

metaR AG13T12g
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
kinetic law: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
type: Reaction
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110052#
modifier: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_869dea94_62e1_40b8_a284_eaa21d166d66
boundary condition: true
is encoded by: hsa:HG2846-HT2983
type: Species
has only substance units: false
is: SBO:0000252
name: _HG2846_HT2983_1_c
initial amount: NaN
initial concentration: NaN
constant: false

metaR DM atp c
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
name: DM_atp(c)
product: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#
fast: false
reversible: false
reactant: MODEL1310110052#
type: Reaction

metaR r2108
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110052#
modifier: MODEL1310110052#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110052#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true

metaM etoh e
constant: false
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: ethanol
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
is: CHEBI:16236
is: HMDB00108
boundary condition: false

metaR MTHFD2
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.9
reactant: MODEL1310110052#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
modifier: MODEL1310110052#
name: methylenetetrahydrofolate dehydrogenase (NAD)
product: MODEL1310110052#
fast: false
reversible: true
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_91b86524_f04d_4538_8eca_6f7e755be157
boundary condition: true
type: Species
is encoded by: hsa:2686
name: GGT7
has only substance units: false
is: A0PJJ9
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_949558a4_f7e6_4dcb_9cb2_7256554f1671
is: P07864
constant: false
name: LDHC
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:3948
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_a887f4c5_da5b_49a7_80c6_cbd78ea7a0b8
initial concentration: NaN
type: Species
has only substance units: false
name: ATP5J
is: SBO:0000252
is encoded by: hsa:522
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_2d79df55_c86d_4796_ada1_ba3323d53261
initial concentration: NaN
name: ENPP2
is encoded by: hsa:5168
has only substance units: false
is: SBO:0000252
is: Q13822
constant: false
boundary condition: true
type: Species
initial amount: NaN

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaM dadp m
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: CHEBI:57667
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB01508
name: dADP(3-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_e8c32f2c_02f0_4382_8748_717239ba3c60
initial amount: NaN
initial concentration: NaN
name: B4GALT2
boundary condition: true
type: Species
is encoded by: hsa:8704
has only substance units: false
is: SBO:0000252
constant: false

metaM octe5coa m
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
is: SBO:0000247
name: 5-octenoylcoa
constant: false

metaM lnlncgcrn m
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB06318
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1
boundary condition: false
type: Species
constant: false
has only substance units: false
name: gamma-linolenyl carnitine

metaM ptrc e
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
boundary condition: false
is: CHEBI:326268
constant: false
is: SBO:0000247
name: Putrescine
has only substance units: false
is: C00134
type: Species
is: HMDB01414

http://identifiers.org/biomodels.db/MODEL1310110052#_dd869155_f0d0_45fd_bdbb_52858671d5ac
boundary condition: true
name: PIP4K2A
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:5305
is: SBO:0000252
is: P48426
constant: false

metaR r2107
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: MODEL1310110052#
fast: false
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110052#

metaM dump c
name: dUMP
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial amount: NaN
constant: false
is: C00365
is: CHEBI:246422
is: HMDB01409
type: Species

metaM acnam n
boundary condition: false
has only substance units: false
name: N-acetylneuraminate
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00230
is: CHEBI:35418
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
constant: false

metaM HC01842 c
type: Species
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
is: SBO:0000247
is: CHEBI:31997
initial concentration: 1.0
initial amount: NaN
constant: false
name: Phosphodimethylethanolamine
has only substance units: false
boundary condition: false

metaR CITL
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110052#
name: Citrate lyase
modifier: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_31c5fd60_cda0_4704_bfc0_143f289eba1c
is: SBO:0000252
is encoded by: hsa:80025
name: PANK2
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
constant: false
boundary condition: true

metaM dadp n
name: dADP(3-)
is: HMDB01508
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:57667
initial amount: NaN

metaM m2mn l
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
type: Species
is: HMDB06537
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine

metaR CYSTA
name: cysteine transaminase
fast: false
reversible: true
kinetic law: MODEL1310110052#
is described by: ECO:0000304
type: Reaction
product: MODEL1310110052#
is: SBO:0000176
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.6.1.1
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110052#_cb3d4bd9_0a82_40e0_a7cb_ce5a7a7962b6
constant: false
is encoded by: hsa:55902
initial amount: NaN
type: Species
has only substance units: false
name: ACSS2
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q5QPH3

metaM 2mcit e
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:15598
is: HMDB00379
name: 2-methylcitrate(3-)

metaR ATPtx
fast: false
kinetic law: MODEL1310110052#
name: ATP transporter, peroxisomal
type: Reaction
product: MODEL1310110052#
is: SBO:0000185
reactant: MODEL1310110052#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ

metaM 3hpp m
is: HMDB00700
is: SBO:0000247
initial concentration: 1.0
name: 3-hydroxypropionate
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:16510
constant: false

metaM HC00229 e
initial concentration: 1.0
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
is: CHEBI:28189
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: Isomaltose
is: SBO:0000247
boundary condition: false

metaR KSII CORE4t
is: SBO:0000185
kinetic law: MODEL1310110052#
fast: false
name: keratan sulfate II (core4) transport, golgi to extracellular
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR HISTAtu
is: SBO:0000185
type: Reaction
product: MODEL1310110052#
reversible: true
kinetic law: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
modifier: MODEL1310110052#
is described by: ECO:0000269
name: Histamine uniport
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

http://identifiers.org/biomodels.db/MODEL1310110052#_6c6f389c_df3e_406f_b7b7_c167a81e2165
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
name: _AV717590_1_c
is encoded by: hsa:AV717590
constant: false
is: SBO:0000252
initial concentration: NaN

metaR RE1796M
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
type: Reaction
modifier: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.145
product: MODEL1310110052#
reversible: true
name: RE1796

metaR UMPK
reversible: true
product: MODEL1310110052#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
name: UMP kinase
reactant: MODEL1310110052#
is: SBO:0000176
type: Reaction

metaR r0753
kinetic law: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
reversible: true
modifier: MODEL1310110052#
is: SBO:0000176
product: MODEL1310110052#
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5

http://identifiers.org/biomodels.db/MODEL1310110052#_1e79e161_023a_4400_8617_c97700190375
has only substance units: false
name: TSTA3
is encoded by: hsa:7264
boundary condition: true
initial amount: NaN
type: Species
is: Q13630
is: SBO:0000252
initial concentration: NaN
constant: false

metaR GALtly
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#
product: MODEL1310110052#
name: galactose efflux from lysosome
type: Reaction
reversible: false

metaR GLYCTO1p
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
is described by: ECO:0000269
modifier: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
name: Glycolate oxidase, peroxisome
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.3.15
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110052#_c79ed4e6_7656_4725_adf6_24cf9c05c64f
name: LDHA
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
is: P00338
boundary condition: true
is encoded by: hsa:3939
type: Species

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

metaM fe3 c
constant: false
initial concentration: 1.0
is: HMDB12943
is: SBO:0000247
initial amount: NaN
name: Fe3+
boundary condition: false
notes: FORMULA: Fe CHARGE: 3
type: Species
has only substance units: false

metaR GALASE5ly
reversible: false
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110052#
fast: false
is: SBO:0000176
name: beta-galactosidase, lysosomal
is described by: ECO:0000000

metaR FAOXC24C22x
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Fatty acid beta oxidation(C24-->C22)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_3672030d_f52a_4d27_bd8c_ec11250c5c8e
type: Species
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:51227
name: PIGP

metaR BCDO
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (53630.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.14.99.36 Confidence Level: 4 AUTHORS: PMID:10799297,PMID:11401432,PMID:1503811 NOTES:IT
type: Reaction
modifier: MODEL1310110052#
is described by: ECO:0000269
fast: false
reversible: false
kinetic law: MODEL1310110052#
name: beta-Carotene dioxygenase
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.14.99.36
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110052#_93739656_258c_463e_93fb_c491040900f1
is encoded by: hsa:7991
name: TUSC3
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_53219f5c_2764_4d47_a3d3_ea4ad13317ba
type: Species
is: E9PNG0
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:271
initial amount: NaN
name: AMPD2
boundary condition: true

metaM slfcys c
name: S-Sulfo-L-cysteine
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C3H8NO5S2 CHARGE: -1
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00731
has only substance units: false
is: C05824

http://identifiers.org/biomodels.db/MODEL1310110052#_ab7743e6_5f64_4ec2_957b_341fd8036fa8
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2194
constant: false
type: Species
has only substance units: false
name: FASN
is: P49327

metaM mmcoa R m
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
boundary condition: false
is: SBO:0000247
is: CHEBI:57326
constant: false
is: HMDB01269
name: (R)-methylmalonyl-CoA(5-)

http://identifiers.org/biomodels.db/MODEL1310110052#_43a6033d_4e5d_4c7a_9c12_cc7335c367a2
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:115
is: SBO:0000252
constant: false
is: O60503
type: Species
initial amount: NaN
name: ADCY9

http://identifiers.org/biomodels.db/MODEL1310110052#_a922fd84_4f54_403b_886e_c63a3382f131
initial concentration: NaN
name: ACSL4
boundary condition: true
constant: false
is: Q5JWV8
type: Species
is encoded by: hsa:2182
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR r0754
reactant: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
product: MODEL1310110052#
reversible: true
is: SBO:0000176
modifier: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_44bb7a94_1f3d_4dd8_b3c0_10a5fe17fe8d
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AU149534
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
name: _AU149534_1_c

http://identifiers.org/biomodels.db/MODEL1310110052#_d8ddedc3_9d16_466a_9240_10d7ba72fa74
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
name: HAS2
is encoded by: hsa:3037
is: Q92819

metaM leuktrF4 c
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:27491
name: leukotriene F4
initial amount: NaN
has only substance units: false
is: HMDB06465

http://identifiers.org/biomodels.db/MODEL1310110052#_0305918e_aa7e_472f_95f1_b7e79585f09c
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:54981
is: Q9NWW6
has only substance units: false
name: NMRK1
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_13d9f31d_cb57_4563_bc5f_bcc1f19aa5a3
is: SBO:0000252
constant: false
boundary condition: true
name: ACP1
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is: P24666
is encoded by: hsa:52

metaM octd11ecoa m
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB06294
name: 11-octadecenoylcoa

metaM c226coa c
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
name: cervonyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205479
is: SBO:0000247
boundary condition: false
is: C16169
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1

metaM i c
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: CHEBI:16382
initial concentration: 1.0
name: iodide
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB12238
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_a99f30b6_42b5_4b63_a016_17b6481ce1a8
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: ENPP1
is encoded by: hsa:5167
is: P22413

metaM 2mcit c
boundary condition: false
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
is: HMDB00379
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:15598
name: 2-methylcitrate(3-)

metaM elaidcrn m
boundary condition: false
is: SBO:0000247
is: HMDB06464
name: Elaidic carnitine
type: Species
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0

metaM fe3 e
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
name: Fe3+
boundary condition: false
is: CHEBI:29034
type: Species
constant: false
is: HMDB12943
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_3b15c52c_dc81_4624_b50a_32745a7b971f
boundary condition: true
initial amount: NaN
type: Species
name: UPP1
is encoded by: hsa:7378
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false

metaR THYOXt2
fast: false
modifier: MODEL1310110052#
reversible: true
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is: SBO:0000185
product: MODEL1310110052#
name: T4 transport via facilitated diffusion

metaR SPODMm
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000176
product: MODEL1310110052#
fast: false
is described by: ECO:0000304
reversible: false
name: superoxide dismutase
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
is version of: http://identifiers.org/ec-code/1.15.1.1
modifier: MODEL1310110052#
type: Reaction

metaR NRVNCt
reactant: MODEL1310110052#
fast: false
product: MODEL1310110052#
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110052#
is: SBO:0000185
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaM slfcys e
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
name: S-Sulfo-L-cysteine
is: SBO:0000247
is: HMDB00731
type: Species
notes: FORMULA: C3H8NO5S2 CHARGE: -1
initial concentration: 1.0
is: C05824

http://identifiers.org/biomodels.db/MODEL1310110052#_5496b902_924d_432d_a527_e6a919f330dd
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9415
is: O95864
constant: false
is: SBO:0000252
has only substance units: false
type: Species
name: FADS2

metaM occoa m
initial amount: NaN
is: HMDB01070
boundary condition: false
constant: false
type: Species
is: C01944
has only substance units: false
name: Octanoyl-CoA (n-C8:0CoA)
initial concentration: 1.0
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: CHEBI:57386
is: SBO:0000247

metaR r0752
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
is described by: ECO:0000000
type: Reaction
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
product: MODEL1310110052#
modifier: MODEL1310110052#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110052#
is: SBO:0000176
fast: false

metaM tchola x
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
has only substance units: false
is: CHEBI:36257
name: taurocholate
is: HMDB00036
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false

metaM lthstrl r
is: SBO:0000247
is: HMDB01170
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
initial concentration: 1.0
type: Species
name: 5alpha-cholest-7-en-3beta-ol
has only substance units: false
boundary condition: false
is: CHEBI:17168
initial amount: NaN
constant: false

metaR RE2666C
name: RE2666
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:
is: SBO:0000176
type: Reaction
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#

metaM leuktrF4 e
is: SBO:0000247
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:27491
initial amount: NaN
name: leukotriene F4
is: HMDB06465
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_ac357a81_8b6f_4a06_b4a7_e7f35630e251
name: GLA
constant: false
is: Q53Y83
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:2717
is: SBO:0000252
initial amount: NaN

metaR GCCbim
reversible: false
is version of: http://identifiers.org/ec-code/1.8.1.4
product: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
name: glycine-cleavage complex (lipoylprotein) irreversible, mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.10
type: Reaction
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.4.4.2
modifier: MODEL1310110052#
is described by: ECO:0000269
is: SBO:0000176

metaM subeac c
initial concentration: 1.0
name: suberic acid
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C8H12O4 CHARGE: -2
type: Species
is: HMDB00893
initial amount: NaN

metaM HC00822 l
initial concentration: 1.0
is: CHEBI:28681
is: SBO:0000247
type: Species
name: Chitobiose
constant: false
boundary condition: false
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
initial amount: NaN
has only substance units: false

metaM glyald c
is: SBO:0000247
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: HMDB01051
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
name: D-Glyceraldehyde
is: CHEBI:17378
initial amount: NaN
is: C00577
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_319363a1_b143_4e32_a2e6_29930b38f338
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q6ZMR3
name: LDHAL6A
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:160287

metaM i e
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
initial concentration: 1.0
is: HMDB12238
name: iodide
is: CHEBI:16382

http://identifiers.org/biomodels.db/MODEL1310110052#_6170181b_8337_43d5_a6c6_973bbc361abb
type: Species
is: SBO:0000252
is encoded by: hsa:LOC728997
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
name: _LOC728997_1_c

metaR GGH 10FTHF6GLUe
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110052#
product: MODEL1310110052#
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular

metaM dump n
boundary condition: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
constant: false
initial amount: NaN
is: HMDB01409
has only substance units: false
is: SBO:0000247
name: dUMP(2-)
initial concentration: 1.0
is: CHEBI:246422
type: Species

metaR LPCHOLt
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: true
product: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9430701 NOTES:
fast: false
name: lysophosphatidylcholine transport

metaM crm hs c
type: Species
constant: false
boundary condition: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
name: N-acylsphingosine
initial amount: NaN
is: CHEBI:52639
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_8ab645b9_88a3_47f8_9aa1_5a65414ff25e
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
name: _D29675_1_e
is encoded by: hsa:D29675

http://identifiers.org/biomodels.db/MODEL1310110052#_0e56087a_bce0_431d_bc20_137aa54138c0
constant: false
is encoded by: hsa:622
boundary condition: true
type: Species
initial amount: NaN
name: BDH1
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_ae88a557_1f5e_4e1b_9de6_d415f509cd26
is: Q9H2F3
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: HSD3B7
is encoded by: hsa:80270
constant: false
type: Species

metaR NAGA2ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
reversible: false
name: N-acetylgalactosaminidase, alpha-
is: SBO:0000176
fast: false
product: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.2.1.49
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction

metaR r1433
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
is described by: ECO:0000000
fast: false
product: MODEL1310110052#
reversible: false
reactant: MODEL1310110052#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
kinetic law: MODEL1310110052#

metaR BDHm
fast: false
is: SBO:0000176
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
type: Reaction
product: MODEL1310110052#
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.1.30
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
reversible: true
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110052#_96eaf7d8_b81f_4b63_b257_fd1f70231781
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
name: PKM2
constant: false
is encoded by: hsa:5315
initial amount: NaN
is: P14618
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_72654fb7_08e5_4842_8324_39aa4691e6bd
boundary condition: true
name: DGKB
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:1607
is: SBO:0000252
has only substance units: false

metaR r2110
modifier: MODEL1310110052#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaM dadp c
name: dADP
is: C00206
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
type: Species
is: CHEBI:57667
is: HMDB01508

metaR S6T3g
is version of: http://identifiers.org/ec-code/2.8.2.17
product: MODEL1310110052#
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.8.2.21
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
kinetic law: MODEL1310110052#
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110052#
is described by: ECO:0000000

metaR SPODMn
is described by: ECO:0000269
reactant: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#
reversible: false
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
fast: false
name: superoxide dismutase, nuclear
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.15.1.1
type: Reaction

metaM 3tetd7ecoa m
name: 3-hydroxy tetradecenoyl-7-coa
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB05066
type: Species
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
initial concentration: 1.0

metaM ahcys e
is: HMDB00939
name: S-Adenosyl-L-homocysteine
notes: FORMULA: C14H20N6O5S CHARGE: 0
is: C00021
has only substance units: false
is: CHEBI:16680
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM eicostetcoa m
boundary condition: false
is: SBO:0000247
is: C16164
has only substance units: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
initial concentration: 1.0
name: eicosatetranoyl coenzyme A

metaR BALABETAtc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of beta alanine into the intestinal cells by beta transport system
type: Reaction

metaR ALR3
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
name: aldose reductase (acetol)
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21
is: SBO:0000176
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000269
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110052#
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_528fe9cf_1f06_4ced_b113_d03a69a2dfe0
name: PFKL
boundary condition: true
is encoded by: hsa:5211
type: Species
initial amount: NaN
is: P17858
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_cee47d50_8827_44ba_81c2_0f05bb432ff6
constant: false
boundary condition: true
is: Q8WWX8
is: SBO:0000252
is encoded by: hsa:115584
has only substance units: false
type: Species
name: SLC5A11
initial concentration: NaN
initial amount: NaN

metaR r0755
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reversible: true
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
modifier: MODEL1310110052#
is: SBO:0000176
product: MODEL1310110052#

metaM ksi deg4 l
initial amount: NaN
constant: false
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
initial concentration: 1.0
is: SBO:0000247
is: HMDB00868
has only substance units: false
name: keratan sulfate I, degradation product 4
type: Species
boundary condition: false
is: CHEBI:57737

http://identifiers.org/biomodels.db/MODEL1310110052#_281c9937_eda5_4d9c_85a6_7d64e249da23
constant: false
is encoded by: hsa:AI656480
type: Species
has only substance units: false
initial amount: NaN
name: _AI656480_1_m
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR CYTK14
kinetic law: MODEL1310110052#
name: cytidylate kinase (dCMP,UTP)
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
product: MODEL1310110052#
reversible: true
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reactant: MODEL1310110052#

metaR r2111
modifier: MODEL1310110052#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110052#
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR MAN6PI
fast: false
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
name: mannose-6-phosphate isomerase
product: MODEL1310110052#
modifier: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000304
is: SBO:0000176
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.8
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_dd2a5cc3_9ced_46ff_87a7_eafa2a73dec8
boundary condition: true
constant: false
name: AK4
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:205
has only substance units: false
is: SBO:0000252

metaM 10fthf6glu e
name: 10-formyltetrahydrofolate-[Glu](6)
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00108
type: Species
has only substance units: false
constant: false
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
is: CHEBI:16236
initial concentration: 1.0

metaR MTHFD
name: methylenetetrahydrofolate dehydrogenase (NADP)
modifier: MODEL1310110052#
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.5.1.5
type: Reaction
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110052#
reversible: true
fast: false
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y

http://identifiers.org/biomodels.db/MODEL1310110052#_a955d1c9_9f80_4b9c_b0fe_ddde37d4fb98
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P43353
boundary condition: true
name: ALDH3B1
is encoded by: hsa:221
constant: false
type: Species
initial amount: NaN

metaR r1540
kinetic law: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
reversible: false
type: Reaction
reactant: MODEL1310110052#
modifier: MODEL1310110052#
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false

metaR r1435
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110052#
name: Transport reaction
is described by: ECO:0000000
reversible: false

metaR NACHEX8ly
is: SBO:0000176
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
reactant: MODEL1310110052#
product: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaM fuc1p L c
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28319
is: HMDB01265
has only substance units: false
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
boundary condition: false
constant: false
initial amount: NaN
name: L-Fucose 1-phosphate

http://identifiers.org/biomodels.db/MODEL1310110052#_7f275cba_3d96_4f25_90c6_f14854e2fca2
constant: false
initial amount: NaN
initial concentration: NaN
name: MOGAT2
is: SBO:0000252
is: Q3SYC2
boundary condition: true
has only substance units: false
is encoded by: hsa:80168
type: Species

metaM dump m
is: SBO:0000247
type: Species
name: dUMP(2-)
is: HMDB01409
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial amount: NaN
constant: false
is: CHEBI:246422
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR r0603
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.12
product: MODEL1310110052#
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: true
is: SBO:0000176
modifier: MODEL1310110052#
fast: false
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:

metaR EX sfcys LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for sulfocysteine
type: Reaction

metaR r2112
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110052#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110052#
reversible: true
fast: false
is: SBO:0000185

metaR PE HSter
fast: false
type: Reaction
reversible: true
product: MODEL1310110052#
name: phosphatidylethanolamine scramblase
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
kinetic law: MODEL1310110052#
is: SBO:0000185
reactant: MODEL1310110052#
is described by: ECO:0000000

metaM frdp x
constant: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
type: Species
boundary condition: false
name: farnesyl pyrophosphate(3-)
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:175763
is: HMDB00961

metaR EX elaid LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: elaidic acid exchange
type: Reaction

metaM mi14p c
boundary condition: false
type: Species
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
is: HMDB00968
is: CHEBI:58282
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_d6d07d17_e29f_4c66_99ab_767b0b32e4a5
boundary condition: true
is encoded by: hsa:8034
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is: P16260
constant: false
name: SLC25A16

metaM ahcys c
is: CHEBI:16680
type: Species
name: S-Adenosyl-L-homocysteine
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00939
boundary condition: false
is: C00021

http://identifiers.org/biomodels.db/MODEL1310110052#_6a3282b7_ecd8_42b3_b6ca_ec184322b1dc
initial amount: NaN
has only substance units: false
is: O75964
name: ATP5L
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:10632
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_7aa421be_be74_4953_a62d_bf28b8b459dd
boundary condition: true
initial amount: NaN
has only substance units: false
is: B7Z7I0
constant: false
is encoded by: hsa:8277
is: SBO:0000252
initial concentration: NaN
name: TKTL1
type: Species

metaR MTHFC
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
name: methenyltetrahydrofolate cyclohydrolase
is described by: ECO:0000134
kinetic law: MODEL1310110052#
fast: false
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.5.1.5
reactant: MODEL1310110052#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true

metaR r1434
fast: false
is described by: ECO:0000000
product: MODEL1310110052#
type: Reaction
name: Transport reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000185

metaR H3MTer L
reversible: false
modifier: MODEL1310110052#
name: H3 mannosyltransferase, endoplasmic reticulum
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
type: Reaction
is: SBO:0000176
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_e5bf5b92_da3f_42e7_85c2_3eba94665972
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:501
boundary condition: true
is: E7EPT3
name: ALDH7A1

metaM amp c
initial amount: NaN
is: CHEBI:3322
is: HMDB00045
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2
initial concentration: 1.0
is: C00020
has only substance units: false
constant: false
boundary condition: false
name: AMP
type: Species

metaM acgam6p c
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
is: CHEBI:57513
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: N-acetyl-D-glucosamine 6-phosphate(2-)
is: HMDB01062

metaR r0311
is: SBO:0000176
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
type: Reaction
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
reactant: MODEL1310110052#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.9

metaM elaidcrn c
name: Elaidic carnitine
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
is: SBO:0000247
constant: false
is: HMDB06464

http://identifiers.org/biomodels.db/MODEL1310110052#_0c9658ae_08b6_46cc_ad79_4becc25fbfe2
initial concentration: NaN
type: Species
name: SUOX
is: P51687
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:6821
constant: false

metaM nm2masn g
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C42H70N3O30X CHARGE: 0
is: SBO:0000247
type: Species
boundary condition: false
is: C05884
initial concentration: 1.0

metaM crm hs g
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:52639
name: N-acylsphingosine
constant: false
initial concentration: 1.0

metaR r1164
is: SBO:0000176
type: Reaction
reactant: MODEL1310110052#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
name: EC:2.3.1.26
kinetic law: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#

metaR 3SALAASPm
reactant: MODEL1310110052#
type: Reaction
reversible: true
is: SBO:0000185
modifier: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
kinetic law: MODEL1310110052#
name: cysteinesulfinate-aspartate mitochondrial shuttle
fast: false
is described by: ECO:0000304

metaM pail34p hs c
type: Species
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
is: CHEBI:57658

metaR C4STMO1r
product: MODEL1310110052#
reversible: false
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
fast: false
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
type: Reaction
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.72

http://identifiers.org/biomodels.db/MODEL1310110052#_357440b0_ef7b_4b03_8f09_ece5cb1f5618
is encoded by: hsa:4200
boundary condition: true
is: P23368
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: ME2
has only substance units: false
initial amount: NaN

metaR FAOXTC162TC142m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C16:2-->C14:2)m
type: Reaction

metaR r1856
is: SBO:0000185
modifier: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
reversible: false
product: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110052#
is described by: ECO:0000000

metaM cs a deg1 l
is: CHEBI:57455
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
is: HMDB01354

metaM 3ttetddcoacrn e
has only substance units: false
is: SBO:0000247
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
constant: false
boundary condition: false
type: Species
is: HMDB02014
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C21H37NO5 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110052#_f1339b2d_6f3a_464b_ac2f_958f8c7aa6af
is: Q5JAM2
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
constant: false
initial concentration: NaN
name: ALAS1
is encoded by: hsa:211

metaR r1431
reactant: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
is: SBO:0000176
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
kinetic law: MODEL1310110052#
reversible: false

metaR r1544
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaM m5masnB2 g
is: HMDB00968
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
boundary condition: false
notes: FORMULA: C52H87N2O40X CHARGE: 0
initial concentration: 1.0
is: CHEBI:58282
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species

metaM g2m8mpdol L r
boundary condition: false
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: C05870
notes: FORMULA: C1900H3128N20O720P20 CHARGE: -20

metaM mi145p c
type: Species
constant: false
is: CHEBI:203600
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB01498
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)

http://identifiers.org/biomodels.db/MODEL1310110052#_9700090b_ae2b_4747_bce2_06211ebfff7a
is encoded by: hsa:BE966236
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
name: _BE966236_1_m
has only substance units: false
constant: false
initial amount: NaN

metaM glyald m
has only substance units: false
type: Species
boundary condition: false
constant: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17378
name: D-glyceraldehyde
is: HMDB01051

metaR LEUyLAThtc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_99dd7254_a8f5_4446_be19_95311bff3613
name: _AI539321_1_c
constant: false
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:AI539321
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR FAOXC121C101m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:1-->C10:1)m
type: Reaction

metaM ksi deg27 l
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:12936
is: HMDB00143
is: SBO:0000247
name: keratan sulfate I, degradation product 27
initial concentration: 1.0
constant: false

metaM vitd3 e
is: CHEBI:28940
initial amount: NaN
type: Species
is: HMDB00876
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: calciol
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1

metaM amp e
is: SBO:0000247
name: AMP
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: C00020
initial concentration: 1.0
is: CHEBI:456215
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00045

metaR C4DCCACT
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinyl carnitine into cytosol
type: Reaction

metaM octd11ecoa c
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
boundary condition: false
type: Species
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5280771
name: 11-octadecenoylcoa
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM ksi deg40 l
has only substance units: false
notes: FORMULA: C40H68N2O31 CHARGE: 0
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
name: keratan sulfate I, degradation product 40
initial concentration: 1.0
is: HMDB00143
is: CHEBI:12936

metaM tddedicoa m
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5280771
initial amount: NaN
initial concentration: 1.0
name: trans3,6dodecadienoylcoa
boundary condition: false
constant: false

metaM Ser Thr g
initial concentration: 1.0
is: CHEBI:0
notes: FORMULA: XH CHARGE: 0
has only substance units: false
is: C00124
type: Species
name: protein-linked serine or threonine residue (O-glycosylation site)
is: SBO:0000247
is: HMDB00143
constant: false
boundary condition: false
initial amount: NaN

metaR r0166
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
reversible: false
kinetic law: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#
fast: false
is: SBO:0000176
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
reactant: MODEL1310110052#

metaM 3hodcoa m
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
constant: false
initial amount: NaN
name: (S)-3-Hydroxyoctadecanoyl-CoA
type: Species
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_4386e040_2e35_4579_beef_8e8e1bf48ccb
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:23236
name: PLCB1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_12592858_4ca6_45be_a950_4b1df31db589
is encoded by: hsa:8879
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
name: SGPL1
initial concentration: NaN
is: O95470

http://identifiers.org/biomodels.db/MODEL1310110052#_ca776ebd_1fa1_4081_9a12_5810ac7d1706
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10678
type: Species
is: Q9NY97
initial concentration: NaN
name: B3GNT2

metaM man r
initial concentration: 1.0
type: Species
is: HMDB00169
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false
name: D-mannose
initial amount: NaN
is: CHEBI:16024

metaM docohepcoa m
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
type: Species
name: 2,4,7,10,13,16,19-docosaheptenoylcoa
constant: false
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false

metaM dd5ecoa m
initial amount: NaN
is: C01942
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB13028
name: 5-dodecenoylcoa
type: Species
boundary condition: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
initial concentration: 1.0

metaM glac c
has only substance units: false
is: CHEBI:18268
initial amount: NaN
name: D-glucurono-6,3-lactone
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB06355
constant: false
boundary condition: false
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110052#_9c7131f0_81f9_471d_8960_cd528b1108f1
is encoded by: hsa:5167
constant: false
has only substance units: false
name: ENPP1
is: P22413
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN

metaR ARACHCRNt
type: Reaction
reversible: false
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000185
fast: false
reactant: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000000

metaR EICOSTETt
fast: false
kinetic law: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
name: fatty acid transport via diffusion
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110052#_eb29fb36_9315_4cd1_ad9d_01f936a5aab2
is encoded by: hsa:4719
initial amount: NaN
constant: false
name: NDUFS1
initial concentration: NaN
is: SBO:0000252
is: P28331
boundary condition: true
type: Species
has only substance units: false

metaR r1546
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR RE0344C
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
reversible: true
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000000
product: MODEL1310110052#
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.2.2
name: RE0344
modifier: MODEL1310110052#

metaM stcrn m
is: SBO:0000247
is: HMDB00848
has only substance units: false
boundary condition: false
name: stearoylcarnitine
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_9d433c1a_4149_46c3_8033_4c8997b26f12
type: Species
boundary condition: true
constant: false
name: ATP2B3
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:492
is: Q16720
has only substance units: false

metaM pchol hs m
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:16110
name: Phosphatidylcholine
constant: false
initial amount: NaN
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
is: SBO:0000247

metaM c12dc c
initial concentration: 1.0
name: dodecanedioyl carnitine
is: SBO:0000247
constant: false
notes: FORMULA: C19H34NO6 CHARGE: -1
is: HMDB00623
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN

metaR PRO1xm
type: Reaction
fast: false
product: MODEL1310110052#
is described by: ECO:0000254
is: SBO:0000176
modifier: MODEL1310110052#
reversible: false
reactant: MODEL1310110052#
name: proline oxidase (NAD), mitochondrial
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.5.99.8
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD

metaM vitd3 c
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
is: CHEBI:28940
initial amount: NaN
is: HMDB00876
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
name: calciol

metaM 3tetd7ecoa c
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
name: 3-hydroxy tetradecenoyl-7-coa
is: HMDB05066
type: Species
initial amount: NaN
is: SBO:0000247

metaM etfrd m
has only substance units: false
name: Electron transfer flavoprotein reduced
is: CHEBI:17263
type: Species
constant: false
boundary condition: false
notes: FORMULA: RH2 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00145

metaM frdp r
name: Farnesyl diphosphate
is: HMDB00961
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:175763
is: C00448

http://identifiers.org/biomodels.db/MODEL1310110052#_c6b072a0_6081_47a2_ae7b_9a565422e941
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: _AI024818_1_c
is encoded by: hsa:AI024818
type: Species
boundary condition: true

metaR RE0512M
reactant: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110052#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
name: RE0512

metaM Ser Thr l
boundary condition: false
is: CHEBI:58190
has only substance units: false
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
is: HMDB00224
type: Species
initial concentration: 1.0
constant: false
name: protein-linked serine or threonine residue (O-glycosylation site)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_91dc5ebc_f29c_4327_85d5_2a2926764e4c
is: SBO:0000252
is encoded by: hsa:7357
is: Q16739
initial concentration: NaN
name: UGCG
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_600dcd72_08bf_4938_99f3_7ae0375a87ed
name: SLC34A2
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: O95436
constant: false
has only substance units: false
type: Species
is encoded by: hsa:10568
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_fa4b061e_19b1_49a0_a19b_efcbcbd24673
type: Species
name: ACAT1
is encoded by: hsa:38
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is: P24752
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_8418d44c_3be2_4a4f_be37_3c0e2cd2f551
is encoded by: hsa:8883
initial concentration: NaN
constant: false
initial amount: NaN
name: NAE1
is: SBO:0000252
has only substance units: false
is: A8MU28
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_c05996b0_da7a_49c5_904a_ef3974598fe7
type: Species
initial concentration: NaN
is encoded by: hsa:1468
constant: false
has only substance units: false
name: SLC25A10
is: SBO:0000252
is: Q9UBX3
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_9794de46_84d1_46cb_897d_5d47977e43f4
is: SBO:0000252
constant: false
name: VNN3
is encoded by: hsa:55350
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR r1548
type: Reaction
reactant: MODEL1310110052#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110052#
is: SBO:0000185
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000

metaM vacccoa c
is: http://identifiers.org/pubchem.compound/9543677
type: Species
name: vaccenyl coenzyme A
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
initial concentration: 1.0
constant: false
is: HMDB06521
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR NODe
product: MODEL1310110052#
kinetic law: MODEL1310110052#
name: NODe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
type: Reaction
fast: false
reversible: true

metaR EX ksi deg1 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I, degradation product 1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_a59dfc14_f17c_4653_bb63_ed5a6b3636e1
boundary condition: true
is encoded by: hsa:2984
initial concentration: NaN
name: GUCY2C
is: P25092
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaM noncoa m
boundary condition: false
notes: FORMULA: C30H48N7O17P3S CHARGE: -4
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB13028
initial concentration: 1.0
constant: false
name: nonanoylcoa
initial amount: NaN
is: C01942

http://identifiers.org/biomodels.db/MODEL1310110052#_ff5f6cf6_18da_4ce7_8ac7_ff0cffcdd6e0
boundary condition: true
is: SBO:0000252
type: Species
name: RDH16
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: O75452
constant: false
is encoded by: hsa:8608

http://identifiers.org/biomodels.db/MODEL1310110052#_6a8dcc00_5670_4d53_839b_e201b2a9befa
is encoded by: hsa:5281
initial concentration: NaN
is encoded by: hsa:84720
boundary condition: true
has part: Q6IB04
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000297
constant: false
name: PIGF:PIGO

metaM xol7ah2al m
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: HMDB06894
type: Species
is: CHEBI:27428
initial amount: NaN
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_97a1d47a_ccd0_4a28_8696_da0d9c75eb14
type: Species
initial concentration: NaN
boundary condition: true
name: NMNAT2
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:23057
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_ce397efe_28ba_478c_9ec3_105f09907a6a
is: SBO:0000252
name: HCST
initial amount: NaN
boundary condition: true
is: Q9UBK5
initial concentration: NaN
is encoded by: hsa:10870
has only substance units: false
type: Species
constant: false

metaM 3dpdhb me m
notes: FORMULA: C58H87O4 CHARGE: -1 INCHI: InChI=1S/C58H88O4/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58(60)61)43-56(62-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43,59H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3,(H,60,61)/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate
constant: false
is: SBO:0000247
is: CHEBI:50776
boundary condition: false

metaM prgstrn c
is: SBO:0000247
boundary condition: false
is: HMDB01830
type: Species
initial concentration: 1.0
is: CHEBI:17026
constant: false
name: progesterone
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410
initial amount: NaN
has only substance units: false

metaR GLNCYSNaEx
kinetic law: MODEL1310110052#
reversible: false
fast: false
product: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110052#
name: L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110052#_a7ebc8b8_d1f5_4475_a558_763193e240ca
type: Species
initial concentration: NaN
is encoded by: hsa:5152
name: PDE9A
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_b94e3d72_ee1a_4df1_badd_5319508aec1f
is encoded by: hsa:4716
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
name: NDUFB10
has only substance units: false
is: A8K761
is: SBO:0000252
boundary condition: true

metaR r1547
type: Reaction
is: SBO:0000185
product: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR SPODMx
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/1.15.1.1
is described by: ECO:0000269
name: superoxide dismutase, peroxisome
reactant: MODEL1310110052#
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR

metaM gly m
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
has only substance units: false
is: SBO:0000247
is: CHEBI:15428
initial concentration: 1.0
type: Species
name: Glycine
is: C00037
is: HMDB00123
constant: false
initial amount: NaN
boundary condition: false

metaR AG13T6g
kinetic law: MODEL1310110052#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
reactant: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000176
modifier: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_75529c25_bbfd_4c5a_a630_f3e77ae2bc8e
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:4728
initial amount: NaN
name: NDUFS8
boundary condition: true
is: O00217
constant: false

metaM acgal l
name: N-acetyl-D-galactosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
boundary condition: false
is: CHEBI:28037
is: SBO:0000247
initial concentration: 1.0
is: HMDB00212
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaM 3ttetddcoacrn c
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB02014
type: Species
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
notes: FORMULA: C21H37NO5 CHARGE: 0
has only substance units: false

metaR ALAR
is described by: ECO:0000212
product: MODEL1310110052#
reactant: MODEL1310110052#
modifier: MODEL1310110052#
name: alanine racemase
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110052#
is: SBO:0000176
reversible: true
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_c01e4a0e_d727_4ae3_bfb5_9c6471aeba79
has only substance units: false
type: Species
initial concentration: NaN
is: Q9UBF8
boundary condition: true
is: SBO:0000252
name: PI4KB
initial amount: NaN
constant: false
is encoded by: hsa:5298

http://identifiers.org/biomodels.db/MODEL1310110052#_d32e8bc8_4274_4838_a6e2_e28899e23a02
name: GPI
is: P06744
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:2821
boundary condition: true
has only substance units: false

metaR RE3000M
type: Reaction
fast: false
is: SBO:0000176
name: RE3000
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110052#
reversible: true
is described by: ECO:0000000
product: MODEL1310110052#

metaM ksi deg18 l
is: CHEBI:12936
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00143
type: Species
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
constant: false
initial amount: NaN
name: keratan sulfate I, degradation product 18
boundary condition: false

metaR r2341
type: Reaction
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110052#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_6939ca99_d56f_47cd_938e_69fcdbdc1208
initial concentration: NaN
is: P23786
is encoded by: hsa:1376
boundary condition: true
has only substance units: false
initial amount: NaN
name: CPT2
type: Species
is: SBO:0000252
constant: false

metaR r1609
reactant: MODEL1310110052#
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110052#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR r0783
fast: false
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
is: SBO:0000176
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110052#
modifier: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_06314d3f_0ac6_4ee0_8890_dad5ac2897e7
boundary condition: true
has only substance units: false
is encoded by: hsa:5728
initial amount: NaN
initial concentration: NaN
is: F6KD01
type: Species
name: PTEN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_51a5e7c2_51d4_4129_ae01_b8e3168100fb
name: TXNRD1
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:7296
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR THD1m
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.6.1.2
modifier: MODEL1310110052#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES:TDV (2-6-2003)
is described by: ECO:0000269
reactant: MODEL1310110052#
name: NAD(P) transhydrogenase
reversible: true
kinetic law: MODEL1310110052#
type: Reaction

metaM trp L e
initial concentration: 1.0
type: Species
is: CHEBI:16828
is: SBO:0000247
boundary condition: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
has only substance units: false
is: HMDB00929
initial amount: NaN
name: L-tryptophan
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_3c7a5217_9953_4cbb_b5dc_e8ad2217741a
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:84720
name: PIGO
constant: false

metaR r2119
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
modifier: MODEL1310110052#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reversible: true
is described by: ECO:0000000

metaM l2fn2m2masn g
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
constant: false
notes: FORMULA: C68H113N4O49X CHARGE: 0
has only substance units: false
is: CHEBI:28067
initial concentration: 1.0
type: Species

metaM ksi pre30 g
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00175
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
is: CHEBI:58053
is: C00130
initial amount: NaN
initial concentration: 1.0
constant: false
name: keratan sulfate I biosynthesis, precursor 30
boundary condition: false

metaR ADK3
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#
name: adentylate kinase (GTP)
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110052#_6bdb7de4_f82c_4d57_95b8_fa038b123d47
is encoded by: hsa:5959
name: RDH5
is: Q92781
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaM 2octpencoa m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
name: 2,6,9,12,15-octadecapentenoylcoa
is: http://identifiers.org/pubchem.compound/5280355
type: Species

metaR ADPtx
kinetic law: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#
name: ADP transporter, peroxisomal
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
type: Reaction
reversible: true
reactant: MODEL1310110052#

metaM HC02210 e
constant: false
is: CHEBI:34939
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin-d3
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1

metaM dgtp n
initial concentration: 1.0
type: Species
has only substance units: false
name: dGTP
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: C00286
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:16497
is: HMDB01440
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_f3d8eca0_3dbf_4989_9c7b_036ce420a707
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:AI620219
boundary condition: true
type: Species
initial concentration: NaN
name: _AI620219_1_e

metaR ASPTA
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
product: MODEL1310110052#
reversible: true
kinetic law: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000269
modifier: MODEL1310110052#
fast: false
is: SBO:0000176
name: aspartate transaminase

metaR r0784
is: SBO:0000176
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.38
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
fast: false
is described by: ECO:0000000
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#

metaR r1608
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110052#
type: Reaction

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_3d308db2_0304_42c4_a561_1bb43985548f
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:W74642
name: _W74642_1_c

metaR APOCF
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110052#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
product: MODEL1310110052#
reactant: MODEL1310110052#
name: Apocarboxylase formation

metaM HC01104 e
constant: false
boundary condition: false
is: CHEBI:61146
type: Species
is: SBO:0000247
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
initial concentration: 1.0
name: 4-nitrophenyl phosphate(2-)
has only substance units: false
initial amount: NaN

metaR TDCRNe
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of myristoyl carnitine into extra cellular space
type: Reaction

metaM dcsptn1crn c
is: HMDB06321
name: docosa-4,7,10,13,16-pentaenoyl carnitine
type: Species
initial amount: NaN
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false

metaM cs b l
initial amount: NaN
is: CHEBI:36005
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: SBO:0000247
is: HMDB02183
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
has only substance units: false

metaR r0456
is described by: ECO:0000000
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000176
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.32
fast: false
modifier: MODEL1310110052#
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:

metaM trdox m
initial concentration: 1.0
constant: false
is: CHEBI:18191
initial amount: NaN
name: Oxidized thioredoxin
has only substance units: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
boundary condition: false
type: Species
is: SBO:0000247

metaR EX glgchlo LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for beta glucan-glycocholate complex
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_dda66fcf_461b_4585_a6df_05dc7c35923f
has only substance units: false
is encoded by: hsa:55967
name: NDUFA12
is: F8VQS7
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR r1607
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110052#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM hedepecoa m
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: 2,4,7,10,13-hexadecapentenoylcoa
is: HMDB02288
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
notes: FORMULA: C37H52N7O17P3S CHARGE: -4

metaM m3gacpail hs r
has only substance units: false
name: trimannosyl-glucosaminyl-acylphosphatidylinositol (H4)
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C49H88NO29PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16240
is: SBO:0000247
type: Species
is: HMDB03125
initial amount: NaN

metaR EX doco13ac
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

metaM trp L c
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
constant: false
type: Species
has only substance units: false
is: CHEBI:16828
boundary condition: false
is: SBO:0000247
is: HMDB00929
name: L-tryptophan
initial amount: NaN
initial concentration: 1.0

metaM xmp c
initial concentration: 1.0
type: Species
is: HMDB01554
initial amount: NaN
constant: false
is: CHEBI:57464
has only substance units: false
boundary condition: false
is: C00655
name: Xanthosine 5'-phosphate
is: SBO:0000247
notes: FORMULA: C10H11N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00478 EHMN_ABBREVIATION: C00655

metaR ADK1
type: Reaction
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000269
product: MODEL1310110052#
name: adenylate kinase
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false

metaR HCO3 CLt
is described by: ECO:0000269
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM
fast: false
name: bicarbonate transport (Cl-/HCO3- exchange)
reactant: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#

metaM kynate c
is: HMDB00715
type: Species
is: SBO:0000247
constant: false
name: kynurenate
has only substance units: false
is: CHEBI:58454
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717

metaR r2117
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110052#

metaM gd3 hs g
initial amount: NaN
is: CHEBI:28424
type: Species
is: SBO:0000247
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
constant: false
boundary condition: false
name: GD3
initial concentration: 1.0
has only substance units: false

metaR PI345P3P
modifier: MODEL1310110052#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.67
type: Reaction
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
reactant: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
kinetic law: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000176
reversible: false

metaM HC02210 c
initial concentration: 1.0
constant: false
is: CHEBI:34939
name: prostaglandin-d3
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
type: Species

metaR ACCOAC
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_db3dff1d_2331_413e_a390_90e6aaed9d15
has part: O95299
is encoded by: hsa:4702
has part: Q13454
is encoded by: hsa:4728
is encoded by: hsa:4700
has part: Q6IBC4
type: Species
constant: false
is encoded by: hsa:4714
is encoded by: hsa:4712
has part: A8K761
has part: Q16718
is encoded by: hsa:4535
has part: O75489
has part: Q9P0J0
is encoded by: hsa:4717
is encoded by: hsa:4715
has part: E5KNH5
is encoded by: hsa:4695
has part: Q7GXZ4
has part: F8VQS7
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
is encoded by: hsa:7991
has part: P17568
is encoded by: hsa:4708
has part: O14561
is encoded by: hsa:4726
is encoded by: hsa:4538
has part: P56556
has part: O95139
has part: P56181
initial concentration: NaN
has part: Q6IBB5
has part: O95169
is encoded by: hsa:4710
is encoded by: hsa:4729
is encoded by: hsa:374291
is encoded by: hsa:4701
has part: Q6IBA0
is: SBO:0000297
is encoded by: hsa:4698
has part: Q549M5
is encoded by: hsa:4696
is encoded by: hsa:4706
is encoded by: hsa:4704
is encoded by: hsa:4536
is encoded by: hsa:4722
has part: O43678
has part: O43674
is encoded by: hsa:4718
is encoded by: hsa:4709
is encoded by: hsa:4716
has part: B1AM93
has only substance units: false
is encoded by: hsa:4539
has part: Q85KV6
has part: Q16795
is encoded by: hsa:4731
has part: O43677
is encoded by: hsa:51079
has part: P03915
has part: P03905
has part: O00483
has part: O95167
has part: O95168
has part: B7Z792
has part: P19404
has part: Q6FG42
is encoded by: hsa:4724
has part: H7C5B8
initial amount: NaN
has part: P28331
has part: O75251
has part: Q6IB80
has part: O00217
is encoded by: hsa:4705
is encoded by: hsa:4540
has part: C9JT23
is encoded by: hsa:4713
is encoded by: hsa:4711

metaR FAOXC12DCc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: formation of dodecanedioyl carnitine
type: Reaction

metaR r1606
is: SBO:0000185
product: MODEL1310110052#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110052#
fast: false
is described by: ECO:0000000

metaR CLOHtex2
product: MODEL1310110052#
is: SBO:0000185
reversible: false
modifier: MODEL1310110052#
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
name: chloride transport via hydroxide countertransport (2:1)
fast: false
kinetic law: MODEL1310110052#

metaM pe hs r
initial concentration: 1.0
is: SBO:0000247
name: phosphatidylethanolamine
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:16038
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
type: Species

metaR NACHEX1ly
kinetic law: MODEL1310110052#
reversible: false
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
modifier: MODEL1310110052#
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_f4bc24ad_f905_4f42_8cb0_52c957cb3172
boundary condition: true
initial concentration: NaN
is: Q9GZV3
is encoded by: hsa:60482
initial amount: NaN
is: SBO:0000252
constant: false
name: SLC5A7
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_6e2855b6_c89e_42f5_b51a_6b2d41677a96
constant: false
is: P51648
name: ALDH3A2
is encoded by: hsa:224
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR PEROXx
kinetic law: MODEL1310110052#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ
is described by: ECO:0000000
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
name: peroxisomal lumped long chain fatty acid oxidation
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110052#
reversible: false
is: SBO:0000176

metaM asp L e
is: SBO:0000247
initial amount: NaN
name: L-aspartate(1-)
initial concentration: 1.0
boundary condition: false
is: CHEBI:29991
has only substance units: false
is: HMDB00191
constant: false
type: Species
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055

metaR r2118
reversible: true
reactant: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110052#_8fd8b816_207b_4dea_940b_0e6f5b7e4c14
name: PYCR1
is encoded by: hsa:5831
constant: false
is: A6NFM2
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species

metaR DOLPMT3 Ler
product: MODEL1310110052#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
is: SBO:0000176
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.260
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#

metaR BTNPL
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.4.10
reversible: false
modifier: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
reactant: MODEL1310110052#
product: MODEL1310110052#
name: holocarboxylase synthestase (biotin protein ligase)
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110052#

metaM val L e
has only substance units: false
initial concentration: 1.0
is: HMDB00883
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
type: Species
name: L-valine
boundary condition: false
is: CHEBI:16414

metaR r2081
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
product: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110052#
fast: false
reactant: MODEL1310110052#

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_32ca3544_765a_49bf_a922_cd7c8531414d
is: SBO:0000252
name: ENTPD3
type: Species
boundary condition: true
is: O75355
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:956
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_7589115c_f80b_4dda_91f9_ade5d85cd1bb
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2629
has only substance units: false
type: Species
constant: false
initial concentration: NaN
boundary condition: true
name: GBA

metaR IDOURtly
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
reversible: true
fast: false
name: iduronate transport into lysososme
is described by: ECO:0000269
modifier: MODEL1310110052#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#

metaR r2115
is described by: ECO:0000000
kinetic law: MODEL1310110052#
reversible: true
modifier: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110052#
fast: false
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_2dd86198_9d10_44b5_bea0_d8fb6523e392
has only substance units: false
is encoded by: hsa:286297
boundary condition: true
initial concentration: NaN
type: Species
constant: false
name: _286297_1_c
initial amount: NaN
is: SBO:0000252

metaM hdd2crn c
name: trans-Hexadec-2-enoyl carnitine
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB06317
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+

metaR CSNATer
modifier: MODEL1310110052#
is described by: ECO:0000254
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.7
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (1384.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:11257506,PMID:3759988 NOTES:mm
reversible: true
fast: false
kinetic law: MODEL1310110052#
name: carnitine O-acetyltransferase, endolasmic reticulum
product: MODEL1310110052#
is: SBO:0000176

metaR r2080
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
modifier: MODEL1310110052#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110052#
is described by: ECO:0000000

metaM tdcrn c
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: myristoyl carnitine
is: HMDB05066
type: Species
notes: FORMULA: C21H41NO4 CHARGE: 0
boundary condition: false
has only substance units: false

metaR RE1522M
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110052#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110052#
modifier: MODEL1310110052#
name: RE1522
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_5256814d_c94a_49fc_a3eb_d886fa4907cf
type: Species
initial amount: NaN
is encoded by: hsa:4831
initial concentration: NaN
constant: false
is encoded by: hsa:4830
has only substance units: false
has part: P22392
is: SBO:0000297
name: NME1:NME2
boundary condition: true
has part: P15531

metaM C05279 m
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
is: HMDB11123
constant: false
initial concentration: 1.0
is: CHEBI:28387
initial amount: NaN
boundary condition: false
name: trans,cis-Lauro-2,6-dienoyl-CoA

metaR TRPt
modifier: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
name: L-tryptophan transport
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
type: Reaction
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000185

metaR EX glyb LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycine betaine exchange
type: Reaction

metaR r2116
kinetic law: MODEL1310110052#
is: SBO:0000185
reversible: true
modifier: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR HSD3A2r
fast: false
type: Reaction
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.1.225
kinetic law: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
reversible: true
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110052#_2d918cdb_5b12_469f_b80d_727e2e207f1c
name: NDUFB6
has only substance units: false
constant: false
is encoded by: hsa:4712
is: O95139
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR r0560
is: SBO:0000176
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
reversible: false
type: Reaction
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110052#_a08054ea_7535_40e5_ba66_9eb48f37526c
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is: Q86XP1
name: DGKH
is encoded by: hsa:160851
initial amount: NaN

metaR SO4t4 2
fast: false
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110052#
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
reversible: true
name: sulfate transport via sodium symport
reactant: MODEL1310110052#
type: Reaction
is: SBO:0000185

metaR r0780
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
product: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:

metaR FUMtm
product: MODEL1310110052#
reversible: true
fast: false
type: Reaction
name: fumarate transport, mitochondrial
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110052#

metaM val L c
constant: false
is: CHEBI:16414
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
name: L-valine
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00883

metaR r0781
reactant: MODEL1310110052#
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110052#
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
is described by: ECO:0000000
modifier: MODEL1310110052#

metaR TETTET6COAtx
is described by: ECO:0000000
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
reversible: true
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110052#
is: SBO:0000185
type: Reaction

metaR r2083
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction

metaR FAOXC141C141OHm
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C14:1OH)m
type: Reaction

metaM m8masn r
is: SBO:0000247
initial concentration: 1.0
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
boundary condition: false
type: Species
is: C05876
constant: false
notes: FORMULA: C70H117N2O55X CHARGE: 0
has only substance units: false
initial amount: NaN

metaM dhlam m
is: SBO:0000247
constant: false
type: Species
name: dihydrolipoamide
is: CHEBI:17694
has only substance units: false
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
initial concentration: 1.0
boundary condition: false
is: HMDB00985
initial amount: NaN

metaR FAOXC142C142OHm
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C14:2OH)m
type: Reaction

metaR r2113
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110052#
product: MODEL1310110052#

metaR GALASE10ly
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110052#
reversible: false
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR THYMDtm
product: MODEL1310110052#
fast: false
name: thymd transport
type: Reaction
modifier: MODEL1310110052#
is described by: ECO:0000269
kinetic law: MODEL1310110052#
is: SBO:0000185
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:TDV
reactant: MODEL1310110052#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110052#_c34208e6_d42e_429f_9be5_e9528362d7ae
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
name: PPA1
is encoded by: hsa:5464
is: Q15181
constant: false
boundary condition: true

metaM tdcrn e
has only substance units: false
initial concentration: 1.0
name: myristoyl carnitine
is: HMDB05066
type: Species
notes: FORMULA: C21H41NO4 CHARGE: 0
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_6efa2ffd_5f06_4e1b_a5fb_066055abdde0
name: ADSL
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:158
is: SBO:0000252
boundary condition: true

metaR r2082
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110052#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110052#
reactant: MODEL1310110052#
reversible: true
kinetic law: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110052#_146832d3_da79_4818_8fff_a98605b08722
boundary condition: true
name: ALDH3B2
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P48448
is encoded by: hsa:222
initial amount: NaN
type: Species
constant: false

metaR TMDK1m
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.1.21
modifier: MODEL1310110052#
fast: false
name: thymidine kinase (ATP:thymidine)
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:9342341 NOTES:TV
type: Reaction
is: SBO:0000176

metaR 5MTHFt
fast: false
reversible: true
is described by: ECO:0000269
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
type: Reaction
is: SBO:0000185
product: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_2da2878e_5cd6_4c33_a2ea_3f90381fd793
is encoded by: hsa:4708
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: H7C5B8
has only substance units: false
type: Species
constant: false
initial concentration: NaN
name: NDUFB2

metaR r2114
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110052#
fast: false
reversible: true
reactant: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
kinetic law: MODEL1310110052#

metaR G14T15g
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110052#
reactant: MODEL1310110052#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is: SBO:0000176
product: MODEL1310110052#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90

http://identifiers.org/biomodels.db/MODEL1310110052#_67108b09_65e2_47d3_b223_0b3f9167578a
constant: false
is: SBO:0000252
is encoded by: hsa:2639
type: Species
initial concentration: NaN
has only substance units: false
is: Q92947
boundary condition: true
name: GCDH
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_1fb9f2df_5469_41cd_bd0d_096303c27979
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is: P09417
name: QDPR
initial amount: NaN
boundary condition: true
is encoded by: hsa:5860
is: SBO:0000252

metaR CLPNDCOAtx
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#
kinetic law: MODEL1310110052#

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaM pe hs m
is: CHEBI:16038
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: false
is: SBO:0000247
name: phosphatidylethanolamine
initial concentration: 1.0

metaM octdececoa m
initial concentration: 1.0
constant: false
is: SBO:0000247
name: octadecenoylcoa
is: http://identifiers.org/pubchem.compound/5280355
initial amount: NaN
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false

metaR CO2t
reactant: MODEL1310110052#
name: CO2 transporter via diffusion
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
is: SBO:0000185
product: MODEL1310110052#

metaR 3SALATAim
reversible: false
is: SBO:0000176
type: Reaction
product: MODEL1310110052#
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial
modifier: MODEL1310110052#
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_62c1be3b_9cde_4dec_9531_6626ecb5e19c
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: ADCY10
initial amount: NaN
is encoded by: hsa:55811
is: F5GWS5
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_84ebbd7d_4b59_43df_b604_a5880534771e
name: TMEM91
is: C9JZ62
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:641649

metaR r0450
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.3
modifier: MODEL1310110052#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
type: Reaction
reversible: true

metaM trdox c
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
initial concentration: 1.0
is: CHEBI:18191
type: Species
is: C00343
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
name: Oxidized thioredoxin
is: SBO:0000247

metaR STRDNCt
type: Reaction
reversible: true
kinetic law: MODEL1310110052#
is: SBO:0000185
name: fatty acid transport via diffusion
reactant: MODEL1310110052#
fast: false
product: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaR SERDGLYexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110052#
type: Reaction
is: SBO:0000185
name: D-Serine/Glycine reversible exchange
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#

metaM ddsmsterol r
type: Species
is: HMDB03896
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
is: SBO:0000247
name: 7-dehydrodesmosterol
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:27910

http://identifiers.org/biomodels.db/MODEL1310110052#_d0327eb6_6f07_43e4_a7cd_ced985b7062e
boundary condition: true
is encoded by: hsa:BG035985
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
name: _BG035985_1_c
initial concentration: NaN

metaM pail5p hs n
initial concentration: 1.0
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
type: Species
initial amount: NaN
is: CHEBI:57795
constant: false
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
has only substance units: false
is: SBO:0000247

metaM octdececoa c
name: octadecenoylcoa
is: HMDB06351
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
type: Species

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaR UAGALDP
reversible: false
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000176
name: UDP-N-acetylgalactosamine diphosphorylase
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction

metaR 2HBt2
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000269
reversible: true
fast: false
kinetic law: MODEL1310110052#
product: MODEL1310110052#
name: 2-hydroxybutyrate cotransport with proton
modifier: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#

metaR GLACter
fast: false
product: MODEL1310110052#
reactant: MODEL1310110052#
name: D-glucurono-6,3-lactone transport, endoplasmic reticulum
type: Reaction
reversible: true
kinetic law: MODEL1310110052#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:3779687 NOTES:NCD
is described by: ECO:0000000

metaR UDPGALtg
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000269
name: UDP-Gal Golgi transport via CMP antiport
fast: false
reactant: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
is: SBO:0000185
reversible: true

metaM atp x
initial concentration: 1.0
name: ATP(4-)
constant: false
is: HMDB00538
is: CHEBI:57299
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
is: C00002

metaR r1600
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110052#
product: MODEL1310110052#
fast: false
reversible: true
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110052#_8b81fb20_ab2b_499d_8edc_c509fcf9d5c0
has only substance units: false
is: Q9H6Y6
type: Species
name: MYO5B
constant: false
initial amount: NaN
is encoded by: hsa:4645
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_5796df04_d94c_4ef3_b4fd_67912b3b8644
has only substance units: false
is: E9KL48
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:2746
name: GLUD1

http://identifiers.org/biomodels.db/MODEL1310110052#_9aa2c9ff_01b3_450b_a184_42a9e885a9ee
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:1743
name: DLST
is: P36957

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaR r0671
modifier: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#
fast: false
reversible: false
name: (R)-4-Phosphopantothenate:L-cysteine ligase EC:6.3.2.5
is: SBO:0000176
type: Reaction
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.2.1.22
notes: GENE_ASSOCIATION: (2717.1) or (6173.1) SUBSYSTEM: CoA synthesis EC Number: 6.3.2.5 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:12906824,PMID:15893380 NOTES:

metaM tetdecdicoa m
boundary condition: false
has only substance units: false
is: HMDB02288
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: 5,8-tetradecadienoylcoa
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
constant: false

metaR RE3004M
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE3004
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110052#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110052#
is: SBO:0000176
modifier: MODEL1310110052#
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110052#_ace6a0ec_8bc6_494f_a36e_60754e7c3ad2
name: HMGCLL1
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:54511
initial amount: NaN
has only substance units: false
is: Q9NT06

metaM retinol cis 11 c
is: SBO:0000247
is: CHEBI:16302
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: 11-cis-retinol
is: HMDB06216
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
boundary condition: false
initial concentration: 1.0

metaM CE2431 m
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:57795
constant: false
has only substance units: false
name: cis-deca-4-enoyl-CoA

metaM dhor S c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
boundary condition: false
is: HMDB03349
name: (S)-dihydroorotate
has only substance units: false
is: CHEBI:30864
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_b43a65eb_212a_4574_aa75_e23fbab6882d
constant: false
boundary condition: true
is: Q9NY65
name: EHHADH
type: Species
is encoded by: hsa:1962
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR BILIRED
is version of: http://identifiers.org/ec-code/1.3.1.24
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000000
fast: false
reversible: false
reactant: MODEL1310110052#
type: Reaction
is: SBO:0000176
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
name: Nad(p)h biliverdin reductase

metaR PPItm
kinetic law: MODEL1310110052#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
product: MODEL1310110052#
is described by: ECO:0000134
reactant: MODEL1310110052#
type: Reaction
is: SBO:0000185
name: diphopshate transporter, mitochondrial

metaR 3MOPte
kinetic law: MODEL1310110052#
type: Reaction
fast: false
is described by: ECO:0000134
reactant: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is: SBO:0000185
name: Transport of 3-methyl-2-oxopentanoate

metaM acac m
is: CHEBI:13705
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: HMDB00060
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
has only substance units: false
name: acetoacetate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_262053ad_617f_4de9_bb0f_fee430c70138
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI348006
name: _AI348006_1_c
is: SBO:0000252
type: Species
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_a0cda5ce_438b_48a7_8231_b2b890a58e3e
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10331
boundary condition: true
is: Q9Y2A9
is: SBO:0000252
initial amount: NaN
name: B3GNT3
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_32906426_0b5d_4726_92b4_7e3f53c7cdc9
is: Q9UN76
boundary condition: true
has only substance units: false
is encoded by: hsa:11254
initial concentration: NaN
is: SBO:0000252
name: SLC6A14
type: Species
initial amount: NaN
constant: false

metaR TTDCPT1
type: Reaction
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110052#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine O-palmitoyltransferase
is: SBO:0000176
reactant: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1374.1) or (1375.2) or (126129.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_451a096d_661a_4d69_aa8d_2a9076ef3eac
name: SULT1E1
is: P49888
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:6783
initial amount: NaN

metaR TRPATB0tc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Tryptophan into the intestinal cells by ATB0 transporter
type: Reaction

metaR PPCOAOm
fast: false
reversible: false
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110052#
is described by: ECO:0000269
kinetic law: MODEL1310110052#
is: SBO:0000176
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
type: Reaction

metaM asp L m
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial amount: NaN
initial concentration: 1.0
name: L-aspartate(1-)
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:29991
type: Species
is: HMDB00191

metaR r0899
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
type: Reaction
product: MODEL1310110052#
fast: false
reversible: true
reactant: MODEL1310110052#
is: SBO:0000185
name: Amino acid transporter ATB0+ Facilitated diffusion
kinetic law: MODEL1310110052#
is described by: ECO:0000000

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_87fe593d_de75_455d_8904_0544cb4e1940
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1738
has only substance units: false
is: SBO:0000252
type: Species
name: DLD
is: P09622

metaM arab L e
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:30849
is: HMDB00646
is: SBO:0000247
type: Species
name: L-arabinose
notes: FORMULA: C5H10O5 CHARGE: 0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_b3b9f704_7849_432f_bdb6_b20ef255fac9
name: MTHFD2L
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:441024
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: Q9H903

metaM ksi pre36 g
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
is: CHEBI:28067
type: Species
name: keratan sulfate I biosynthesis, precursor 36
has only substance units: false

metaM mi1p D c
type: Species
name: 1D-myo-inositol 1-phosphate(2-)
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
is: HMDB02985
has only substance units: false
is: SBO:0000247
is: CHEBI:58433

metaR r1605
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110052#
fast: false
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110052#

metaM adrncoa m
name: adrenyl coenzyme A
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205480
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: C16170

http://identifiers.org/biomodels.db/MODEL1310110052#_ac85b587_97be_49dc_902b_a064c69769fa
has only substance units: false
is: SBO:0000297
initial amount: NaN
constant: false
name: VNN3:VNN2:VNN1
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:55350

metaM dlnlcgcrn m
name: dihomo-gamma-linolenyl carnitine
has only substance units: false
constant: false
is: HMDB01311
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:16004

http://identifiers.org/biomodels.db/MODEL1310110052#_28b1c849_032d_44f6_b9a0_1595a76dbe35
constant: false
name: HADHA
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: E9KL44
is encoded by: hsa:3030
boundary condition: true
type: Species
is: SBO:0000252

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_b86171ee_f213_4c28_a915_f5af5a4eed2d
boundary condition: true
name: SUCLA2
is: SBO:0000252
is encoded by: hsa:8803
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: E5KS60
type: Species
constant: false

metaR LINKDEG4ly
kinetic law: MODEL1310110052#
product: MODEL1310110052#
name: degradation of proteoglycan linkage region, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110052#
type: Reaction
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
fast: false

metaR SUCCt2m
name: succinate transport, mitochondrial
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
kinetic law: MODEL1310110052#
reversible: true
modifier: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110052#_ef708dbe_bca6_474f_806e_140e086fe73d
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q9HC58
is encoded by: hsa:57419
is: SBO:0000252
type: Species
has only substance units: false
name: SLC24A3

metaR TRPHYDRO2
is version of: http://identifiers.org/ec-code/1.14.16.4
modifier: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
type: Reaction
fast: false
kinetic law: MODEL1310110052#
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
product: MODEL1310110052#
is: SBO:0000176
reversible: false

metaR BGLUGCHe
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of betaglucans with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR r1604
product: MODEL1310110052#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110052#
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaM co c
initial concentration: 1.0
is: HMDB01361
is: CHEBI:17245
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
name: carbon monoxide
constant: false
initial amount: NaN
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237

metaR SIAASEly
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110052#
reversible: false
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR LYSt4
fast: false
name: L-lysine transport in via sodium symport
modifier: MODEL1310110052#
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000185
product: MODEL1310110052#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (11254.1) or (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
reversible: false
type: Reaction

metaM mthgxl c
constant: false
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
is: CHEBI:17158
name: methylglyoxal
is: SBO:0000247
is: HMDB01167
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110052#_0a321d63_8e4a_43cf_bb78_32cce526e5b0
is encoded by: hsa:5372
initial concentration: NaN
is: A8K003
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
name: PMM1
has only substance units: false
boundary condition: true

metaM formcoa x
constant: false
name: formyl-CoA(4-)
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
has only substance units: false
is: HMDB03419
initial concentration: 1.0
is: CHEBI:57376
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_6d8f5800_5d78_4040_a9f2_a16fcbc9c263
constant: false
boundary condition: true
has only substance units: false
is: Q6FG42
name: NDUFA7
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4701

metaM arab L c
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:30849
is: HMDB00646
name: L-arabinose
notes: FORMULA: C5H10O5 CHARGE: 0
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR DGSNt
type: Reaction
kinetic law: MODEL1310110052#
name: deoyguanosine transport via diffusion
reversible: true
fast: false
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110052#
is: SBO:0000185

metaR C160CPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
name: production of Palmitoylcarnitine
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110052#
type: Reaction
fast: false
reversible: false
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:
product: MODEL1310110052#

metaR UMPK7n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
fast: false
name: UMP kinase (dGTP),nuclear
reactant: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR r1603
reactant: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#
type: Reaction
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR SCPx
modifier: MODEL1310110052#
is: SBO:0000176
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.176
product: MODEL1310110052#
is described by: ECO:0000269
name: peroxisomal thiolase 2

http://identifiers.org/biomodels.db/MODEL1310110052#_6b265829_e100_4e27_b832_3395bd5ef914
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:517
name: ATP5G2
constant: false

metaM L2aadp m
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
constant: false
is: CHEBI:58672
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: L-2-aminoadipate(1-)
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00510

metaR FAOXC161802m
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation fatty acid
reversible: false
modifier: MODEL1310110052#
fast: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110052#

metaM atp r
is: CHEBI:57299
is: HMDB00538
initial amount: NaN
is: C00002
constant: false
is: SBO:0000247
initial concentration: 1.0
name: ATP(4-)
type: Species
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_f2aa636b_6e10_419b_9c22_8d94ad541508
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:AA664770
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
name: _AA664770_1_m

metaR r2497
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
reactant: MODEL1310110052#
reversible: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
fast: false
product: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_12ee7470_3df4_40d9_9fb2_5c6fd3e396dd
name: _AI926493_1_m
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI926493
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species

metaR C160CPT2
is: SBO:0000176
modifier: MODEL1310110052#
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
is described by: ECO:0000269
name: C160 transport into the mitochondria
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110052#_bb332710_c445_4c09_aa3c_7a9086e6fd6d
boundary condition: true
is encoded by: hsa:5313
constant: false
name: PKLR
type: Species
is: P30613
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM co e
initial concentration: 1.0
is: CHEBI:17245
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: carbon monoxide
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
is: HMDB01361

http://identifiers.org/biomodels.db/MODEL1310110052#_de0326b1_0958_40b8_9c1c_6418fd173faa
initial amount: NaN
has only substance units: false
is encoded by: hsa:1350
is: P15954
type: Species
initial concentration: NaN
boundary condition: true
name: COX7C
is: SBO:0000252
constant: false

metaM ksi pre15 g
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 15
type: Species
initial concentration: 1.0
is: C00130
constant: false
is: SBO:0000247
is: HMDB00175
has only substance units: false
is: CHEBI:58053
boundary condition: false
notes: FORMULA: C149H240N10O119S4X CHARGE: -5

metaM vacccrn c
boundary condition: false
initial amount: NaN
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
has only substance units: false
name: Vaccenyl carnitine
is: SBO:0000247
is: HMDB06351
constant: false
initial concentration: 1.0
type: Species

metaM dcsptn1crn m
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
is: HMDB06321
has only substance units: false
type: Species
name: docosa-4,7,10,13,16-pentaenoyl carnitine
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false

metaR r1602
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110052#_e93e0e61_eee7_411e_b443_d861caa3505a
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: O43820
has only substance units: false
name: HYAL3
is encoded by: hsa:8372
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_f594f4d4_b836_4867_9bba_1a5bb4788645
type: Species
has only substance units: false
constant: false
is: B2RBR4
is: SBO:0000252
is encoded by: hsa:6575
boundary condition: true
name: SLC20A2
initial concentration: NaN
initial amount: NaN

metaR r0679
fast: false
reactant: MODEL1310110052#
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
type: Reaction
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110052#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110052#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33

metaM 56dura c
has only substance units: false
name: 5,6-dihydrouracil
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
is: CHEBI:15901
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00076

metaM HC02208 e
name: prostaglandin-d1
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:27696
is: SBO:0000247

metaR MI145PP
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
fast: false
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.3.86
reactant: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.36
is version of: http://identifiers.org/ec-code/3.1.3.56
name: inositol-1,4,5-trisphosphate 5-phosphatase
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: false
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110052#_ac462785_9f21_4cf5_9c6b_f673b05f344a
constant: false
is: Q546E0
type: Species
is encoded by: hsa:2530
boundary condition: true
initial concentration: NaN
name: FUT8
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR 2MB2COAc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 2-methylcrotonoyl-CoA into cytosol
type: Reaction

metaM pe hs c
name: phosphatidylethanolamine
type: Species
is: CHEBI:16038
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR S6T6g
is: SBO:0000176
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
type: Reaction
reversible: false
modifier: MODEL1310110052#
fast: false
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaR r0345
fast: false
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110052#
is: SBO:0000176
product: MODEL1310110052#
reactant: MODEL1310110052#
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
reversible: true
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.13

http://identifiers.org/biomodels.db/MODEL1310110052#_a146c8f5_eb9c_4134_a6f4_4e9eefb9b740
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:2348
name: FOLR1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_64ccb378_b4b4_4c79_8090_f91dba8516af
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:23417
is: SBO:0000252
has only substance units: false
name: MLYCD
is: O95822

metaR SUBERCROT
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_3045bd48_6c79_455e_a1b5_ff078134b2ff
has only substance units: false
initial concentration: NaN
name: NDUFS6
initial amount: NaN
is encoded by: hsa:4726
is: Q6IBC4
type: Species
constant: false
boundary condition: true
is: SBO:0000252

metaR XYLt
is described by: ECO:0000269
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
name: D-xylose reversible transport
product: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110052#
is: SBO:0000185

metaR TMNDNCCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110052#
reversible: false
modifier: MODEL1310110052#
type: Reaction
fast: false
name: carnitine O-palmitoyltransferase
is: SBO:0000176

metaM acac c
is: HMDB00060
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:13705
name: acetoacetate
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_69267ef9_76df_4243_9b46_d3d5122c8403
initial amount: NaN
is: SBO:0000252
is: B4DR31
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1808
type: Species
constant: false
name: DPYSL2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_9ad3201e_8e2d_4adb_8ebd_d321c8ed3276
has only substance units: false
name: EHHADH:ACAA1:HSD17B4:ACOX3
initial amount: NaN
is: SBO:0000297
boundary condition: true
constant: false
has part: O15254
type: Species
is encoded by: hsa:8310
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_e6ddec31_96c5_43cf_b671_3cbc247e910c
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:5277
has only substance units: false
is: P37287
boundary condition: true
name: PIGA

metaM ksii core4 pre9 g
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 9
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
boundary condition: false

metaM 3mb2coa m
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
is: HMDB01493
name: 3-methylbut-2-enoyl-CoA(4-)
type: Species
initial concentration: 1.0
is: CHEBI:57344

metaR AG13T5g
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
product: MODEL1310110052#

metaM HC02208 c
boundary condition: false
is: CHEBI:27696
constant: false
type: Species
initial concentration: 1.0
name: prostaglandin-d1
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_39d943db_3815_4a3a_9337_732abc805000
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3032
name: HADHB
has only substance units: false
constant: false
boundary condition: true
type: Species
is: P55084
initial amount: NaN

metaR RE2625C
kinetic law: MODEL1310110052#
name: RE2625
is described by: ECO:0000000
product: MODEL1310110052#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false
is: SBO:0000176
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_726eb0bc_5578_4bca_b9a2_6f835aa3b3a9
has only substance units: false
is: SBO:0000252
name: FUT8
initial amount: NaN
is encoded by: hsa:2530
boundary condition: true
type: Species
is: B4DFS7
constant: false
initial concentration: NaN

metaR GGH 10FTHF7GLUe
is: SBO:0000176
kinetic law: MODEL1310110052#
fast: false
is described by: ECO:0000000
product: MODEL1310110052#
reactant: MODEL1310110052#
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110052#
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

metaM HC01407 m
constant: false
boundary condition: false
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
name: (S)-Hydroxyhexanoyl-CoA
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28276
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_ee2f4997_cd89_457e_8daa_48ac3089ac71
is: SBO:0000252
boundary condition: true
is: P43353
initial concentration: NaN
name: ALDH3B1
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:221
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_2e3071aa_03df_417f_878d_d342aef680e8
initial amount: NaN
type: Species
has only substance units: false
is: Q9BYZ2
is encoded by: hsa:92483
boundary condition: true
initial concentration: NaN
name: LDHAL6B
is: SBO:0000252
constant: false

metaR COQ3m
reactant: MODEL1310110052#
reversible: false
is version of: http://identifiers.org/ec-code/2.1.1.114
kinetic law: MODEL1310110052#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10777520,PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_2.1.1.114 IT
type: Reaction
modifier: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000269
fast: false
name: methyltransferase COQ3

metaM cs e deg2 l
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
type: Species
constant: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:57455
is: SBO:0000247
is: HMDB01354
initial amount: NaN

metaR TMNDNCCPT2
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
reactant: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000176
is described by: ECO:0000000
reversible: false

metaR ACCOAtr
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ changed name from ACCOArt to ACCOAtr for consistency - NCD
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
reversible: true
name: acetyl-coa transport
type: Reaction
modifier: MODEL1310110052#
is: SBO:0000185
product: MODEL1310110052#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110052#_20803d72_ee3d_4ab5_a90c_42f4d31053dc
is: P23434
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2653
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
name: GCSH
constant: false

metaR GLNASNNaEx
name: L-glutamine/L-asparagine Na-dependent exchange (Gln-L in)
kinetic law: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110052#
reversible: false

metaR ACP1 FMN
product: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.3.2
type: Reaction
is described by: ECO:0000254
is: SBO:0000176
reactant: MODEL1310110052#
fast: false
name: acid phosphatase (FMN)
reversible: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:8522318 NOTES:INVALID ECO TERM: IFH

http://identifiers.org/biomodels.db/MODEL1310110052#_ee3ca392_10aa_4023_9157_6ee4ad8ce133
is: SBO:0000252
initial concentration: NaN
type: Species
name: PRDX1
boundary condition: true
is encoded by: hsa:5052
has only substance units: false
initial amount: NaN
constant: false

metaM 3ivcoa c
is: C05998
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/11966188
is: HMDB06870
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
has only substance units: false
type: Species
name: 3-hydroxyisovalerylcoa
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_c56e8f43_8ba9_4619_91e7_68ca7b27445e
is: P07205
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
name: PGK2
is encoded by: hsa:5232
initial concentration: NaN
type: Species

metaR APOC LYS BTNP
name: proteolysis of apoC-Lys-btn
product: MODEL1310110052#
reactant: MODEL1310110052#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110052#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176

metaM pail5p hs c
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:57795
initial amount: NaN
constant: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)

metaM acac e
is: SBO:0000247
is: HMDB00060
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: CHEBI:13705
initial concentration: 1.0
initial amount: NaN
type: Species
name: acetoacetate
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_6829c739_3499_472f_98e4_e11f4e3c1119
is encoded by: hsa:2184
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: FAH
boundary condition: true
constant: false
type: Species
has only substance units: false
is: P16930

metaM c5dc c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C12H21NO6 CHARGE: 0
initial amount: NaN
name: glutaryl carnitine
is: HMDB13130
is: SBO:0000247
constant: false
boundary condition: false
type: Species

metaR r0130
product: MODEL1310110052#
reactant: MODEL1310110052#
reversible: true
is described by: ECO:0000000
fast: false
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000176
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
type: Reaction
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110052#_d797c52f_7d9f_4268_a387_0c68e9f081b6
is encoded by: hsa:3712
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
is: B3KVI7
name: IVD
type: Species

metaM L2aadp c
is: SBO:0000247
has only substance units: false
is: CHEBI:58672
name: L-2-aminoadipate(1-)
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00510

metaR ACGAMPM
reversible: true
fast: false
product: MODEL1310110052#
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
is: SBO:0000176
name: phosphoacetylglucosamine mutase
is version of: http://identifiers.org/ec-code/5.4.2.3
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110052#

metaM prostgi2 e
initial concentration: 1.0
is: SBO:0000247
is: HMDB01335
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
type: Species
is: CHEBI:57403
name: prostaglandin I2(1-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_8d99bfea_0a1f_457b_8b1b_6a3e17f843a2
has only substance units: false
is: SBO:0000297
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:5213
has part: P08237
type: Species
boundary condition: true
name: PFKM:PFKP

metaR biomass reaction
is described by: ECO:0000134
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
name: biomass_reaction
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
product: MODEL1310110052#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_357cf199_0949_49b1_96f5_e63b5e6484fe
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5150
constant: false
initial concentration: NaN
name: PDE7A
boundary condition: true
is: Q13946
initial amount: NaN
type: Species

metaR MCLACCYSR
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
fast: false
reactant: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
reversible: false
kinetic law: MODEL1310110052#
is: SBO:0000176
name: 3-mercaptolactate:cysteine reductase

http://identifiers.org/biomodels.db/MODEL1310110052#_bef4b1bc_7079_4428_95d1_255b7079901e
has only substance units: false
is: O43865
initial amount: NaN
boundary condition: true
name: AHCYL1
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:10768
initial concentration: NaN

metaR r0892
is: SBO:0000185
product: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
name: Facilitated diffusion
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.27
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_3402170b_77f7_447f_ae4e_7517061498ee
name: DGKB
initial amount: NaN
is: Q9Y6T7
is encoded by: hsa:1607
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
constant: false
boundary condition: true

metaR r1936
reversible: false
fast: false
reactant: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110052#
is: SBO:0000185
is described by: ECO:0000000
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110052#_d0b08a8c_52d9_42b5_947e_c159cfde3369
initial concentration: NaN
is encoded by: hsa:W87865
name: _W87865_1_c
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species

metaR URIt
reversible: true
modifier: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110052#
product: MODEL1310110052#
name: uridine facilated transport in cytosol
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
fast: false

metaM cs a deg3 l
is: HMDB00127
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C31H48NO32S2 CHARGE: -3
is: CHEBI:15748
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_d9b0109b_059e_4a0d_9647_f7d1aa793a1d
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3028
constant: false
initial amount: NaN
initial concentration: NaN
name: HSD17B10
type: Species
is: Q99714

metaR DUMPtn
is described by: ECO:0000000
type: Reaction
fast: false
name: dUMP nuclear transport
kinetic law: MODEL1310110052#
reversible: true
product: MODEL1310110052#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110052#

metaR OAGD3tg
product: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reversible: true
fast: false
name: oagd3 hs intracellular transport
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110052#_b789497f_d490_45f4_8e04_d15386020003
initial amount: NaN
type: Species
name: HAO2
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:51179
is: SBO:0000252

metaM dhf m
is: CHEBI:57451
boundary condition: false
constant: false
name: dihydrofolate(2-)
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
has only substance units: false
initial concentration: 1.0
is: HMDB01056

http://identifiers.org/biomodels.db/MODEL1310110052#_246d64dc_11bf_4311_a028_dba3e61c7218
is: Q8NFL0
name: B3GNT7
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:93010

metaM dd3coa x
initial concentration: 1.0
is: HMDB04257
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
name: 3-dodecenoylcoa
boundary condition: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
type: Species

metaM dd2coa c
has only substance units: false
constant: false
initial amount: NaN
name: trans-Dodec-2-enoyl-CoA
initial concentration: 1.0
is: HMDB03712
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
boundary condition: false
type: Species
is: SBO:0000247

metaM c5dc e
initial concentration: 1.0
notes: FORMULA: C12H21NO6 CHARGE: 0
type: Species
boundary condition: false
is: HMDB13130
name: glutaryl carnitine
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_64c83d4f_1b37_45fc_9bac_fc4f2ad7dfe4
boundary condition: true
name: CPT1C
constant: false
initial concentration: NaN
type: Species
is: Q8TCG5
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:126129

metaM prostgi2 c
initial concentration: 1.0
type: Species
is: CHEBI:57403
is: HMDB01335
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
name: prostaglandin I2(1-)
is: SBO:0000247
has only substance units: false
constant: false

metaM c81crn e
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: octenoyl carnitine
type: Species
constant: false
notes: FORMULA: C15H27NO4 CHARGE: 0
boundary condition: false
is: SBO:0000247
is: HMDB13324

metaR GALASE13ly
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
fast: false
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110052#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.6.4

http://identifiers.org/biomodels.db/MODEL1310110052#_eef52c58_726e_45ef_976b_0669c2e08cc6
name: NDUFA12
initial amount: NaN
constant: false
is: F8VQS7
type: Species
is: SBO:0000252
is encoded by: hsa:55967
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_18e48378_da1a_438f_a0db_08d4163529be
constant: false
is: SBO:0000252
type: Species
boundary condition: true
name: GMPPB
is encoded by: hsa:29925
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_639688b4_14be_4e52_81dc_c65b3073b019
has only substance units: false
name: GGT5
is encoded by: hsa:2687
is: SBO:0000252
is: P36269
initial concentration: NaN
constant: false
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_712e900c_117c_48ff_8d56_13fae4916c18
type: Species
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2348
name: FOLR1

metaR r1821
reversible: false
type: Reaction
modifier: MODEL1310110052#
is: SBO:0000185
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110052#

metaR ACCOAtn
kinetic law: MODEL1310110052#
fast: false
product: MODEL1310110052#
name: acetyl-CoA transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110052#
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaM adrncoa x
has only substance units: false
initial amount: NaN
name: adrenyl coenzyme A
type: Species
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205480
constant: false
is: SBO:0000247
is: C16170
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1

metaM prpncoa m
has only substance units: false
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
is: SBO:0000247
is: CHEBI:57367
constant: false
type: Species
is: HMDB02307
name: acryloyl-CoA(4-)
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM 2obut c
boundary condition: false
constant: false
initial concentration: 1.0
name: 2-Oxobutanoate
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
has only substance units: false
initial amount: NaN
is: C00109
type: Species
is: CHEBI:16763
is: SBO:0000247
is: HMDB00005

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaM mi13p c
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
name: 1D-myo-Inositol 1,3-bisphosphate
is: CHEBI:18225
has only substance units: false
type: Species
is: HMDB06234
initial amount: NaN

metaR AACOAT
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.16
is described by: ECO:0000269
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
modifier: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#
product: MODEL1310110052#
name: Acetoacetyl-CoA:acetate CoA-transferase

metaM amp x
is: C00020
is: SBO:0000247
initial amount: NaN
is: CHEBI:456215
boundary condition: false
name: AMP
initial concentration: 1.0
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: HMDB00045
has only substance units: false
type: Species

metaM c81crn c
notes: FORMULA: C15H27NO4 CHARGE: 0
has only substance units: false
type: Species
constant: false
name: octenoyl carnitine
boundary condition: false
is: HMDB13324
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR r2124
reactant: MODEL1310110052#
is described by: ECO:0000000
modifier: MODEL1310110052#
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110052#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110052#_636c0999_9cb4_42d2_92d6_57debdf25a2b
name: ATP5E
is encoded by: hsa:514
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_a12aad89_ac1a_441c_a09a_e502161864a6
is encoded by: hsa:195814
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: SDR16C5
boundary condition: true
is: B3KT84

metaR r2338
fast: false
product: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110052#
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
reversible: true

metaR DSAT
reversible: false
fast: false
reactant: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
name: dihydrosphingosine N-acyltransferase
product: MODEL1310110052#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_1b44f582_7d63_4299_931f_8c4251a3c997
is encoded by: hsa:28976
name: ACAD9
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q9H845
constant: false

metaR r2084
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
product: MODEL1310110052#
modifier: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
kinetic law: MODEL1310110052#

metaM HC02020 r
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C43H76O2 CHARGE: 0 INCHI: InChI=1S/C43H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-23-41(44)45-36-28-30-42(5)35(32-36)24-25-37-39-27-26-38(34(4)22-20-21-33(2)3)43(39,6)31-29-40(37)42/h24,33-34,36-40H,7-23,25-32H2,1-6H3/t34-,36+,37+,38-,39+,40+,42+,43-/m1/s1
name: Cholesterol-ester-palm
initial concentration: 1.0
constant: false
is: CHEBI:3663
has only substance units: false

metaM vacccrn m
boundary condition: false
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB06351
name: Vaccenyl carnitine
initial concentration: 1.0
type: Species
constant: false

metaR r1826
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is described by: ECO:0000000
fast: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is: SBO:0000185
reactant: MODEL1310110052#
product: MODEL1310110052#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_2084ad5b_5fd0_4e86_9c07_7502bc640d80
is: SBO:0000252
is: Q9Y633
initial concentration: NaN
has only substance units: false
type: Species
constant: false
name: PDE1A
initial amount: NaN
boundary condition: true
is encoded by: hsa:5136

http://identifiers.org/biomodels.db/MODEL1310110052#_ebea0074_1f87_4826_9b7c_70339cb9eaf4
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
name: PDE2A
type: Species
initial amount: NaN
is: Q8IW54
initial concentration: NaN
is encoded by: hsa:5138

http://identifiers.org/biomodels.db/MODEL1310110052#_432ce33d_61ab_4d62_ab08_5b4559eafa26
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:642502
boundary condition: true
type: Species
is: SBO:0000252
constant: false
name: _642502_1_c

metaR OCCOAtx
is described by: ECO:0000000
name: fatty acid intracellular transport
type: Reaction
fast: false
product: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110052#
is: SBO:0000185
kinetic law: MODEL1310110052#

metaM dgtp e
name: dGTP
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: HMDB01440
constant: false
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:16497
initial concentration: 1.0
initial amount: NaN

metaR r2123
fast: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110052#

metaR C3DCe
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of malonyl carnitine into extra cellular space
type: Reaction

metaR r2085
reactant: MODEL1310110052#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
product: MODEL1310110052#

metaR NS26T2g
is version of: http://identifiers.org/ec-code/2.4.99.3
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
fast: false
reversible: false
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
is: SBO:0000176
notes: GENE_ASSOCIATION: (55808.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.3 Confidence Level: 0 AUTHORS: PMID:10536037 NOTES:NCD
is described by: ECO:0000000

metaR SQLEr
fast: false
reactant: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is: SBO:0000176
reversible: false
name: Squalene epoxidase, endoplasmic reticular (NADP)
is version of: http://identifiers.org/ec-code/1.14.13.132
is described by: ECO:0000134
type: Reaction

metaM cbasp e
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00828
is: CHEBI:32814
constant: false
initial concentration: 1.0
is: C00438
is: SBO:0000247
name: N-Carbamoyl-L-aspartate
notes: FORMULA: C5H6N2O5 CHARGE: -2
has only substance units: false

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_78d8d023_72d8_412d_b0dd_85ce24165b35
initial amount: NaN
constant: false
is encoded by: hsa:AI926493
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: _AI926493_1_c

metaM CE2432 m
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:57795
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
constant: false

metaR VLCSp
modifier: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000269
fast: false
reversible: false
name: Very-long-chain-fatty-acid-CoA ligase
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176

metaM 5HPET c
is: CHEBI:57450
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
initial amount: NaN
is: HMDB01193
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: 5(S)-HPETE(1-)
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_aea69518_24a1_4915_9bc4_2db41df1e509
initial amount: NaN
initial concentration: NaN
name: PLCG2
is encoded by: hsa:5336
constant: false
type: Species
is: P16885
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM dhf c
is: SBO:0000247
is: C00415
name: 7,8-Dihydrofolate
boundary condition: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: CHEBI:57451
constant: false
initial amount: NaN
has only substance units: false
is: HMDB01056
type: Species
initial concentration: 1.0

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_15508fbe_5c2b_4302_a97d_05e9ae4ec3b6
constant: false
is: SBO:0000252
is encoded by: hsa:22305
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: _22305_2_c
type: Species
has only substance units: false

metaR r2086
kinetic law: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185
reversible: true
modifier: MODEL1310110052#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110052#
is described by: ECO:0000000

metaR r2122
product: MODEL1310110052#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110052#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_7011e604_427c_49f2_a95f_b6b563f07487
constant: false
initial amount: NaN
boundary condition: true
is: Q9UNU6
initial concentration: NaN
is encoded by: hsa:1582
type: Species
is: SBO:0000252
has only substance units: false
name: CYP8B1

metaM 3ivcoa m
name: 3-hydroxyisovalerylcoa
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: C05998
is: HMDB06870
is: http://identifiers.org/pubchem.compound/11966188

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaM nm4masn g
is: C05882
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C54H90N3O40X CHARGE: 0
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: SBO:0000247

metaR r1824
type: Reaction
name: Y+LAT2 Utilized transport
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110052#
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_405098db_4d7c_40f8_9001_74896babfab5
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:79053
initial amount: NaN
name: ALG8
constant: false
is: A6NDW6
is: SBO:0000252

metaM cl e
boundary condition: false
has only substance units: false
is: CHEBI:3966
initial amount: NaN
is: HMDB00492
notes: FORMULA: Cl CHARGE: -1
name: Chloride
is: SBO:0000247
is: C00115
initial concentration: 1.0
constant: false
type: Species

metaR FAOXC2031836m
type: Reaction
kinetic law: MODEL1310110052#
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:3 -> c18:3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
is: SBO:0000176
reactant: MODEL1310110052#
reversible: false

metaR OAGD3te
reversible: true
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
name: oagd3 hs transport
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110052#_74879f20_d1eb_4c2e_a161_fc19ddf2faf6
initial concentration: NaN
is: Q9NZK7
is encoded by: hsa:30814
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
name: PLA2G2E
type: Species
has only substance units: false

metaR SBTR
reactant: MODEL1310110052#
name: D-sorbitol reductase
product: MODEL1310110052#
is described by: ECO:0000269
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21

metaR r2335
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110052#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
fast: false

metaR r2121
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
product: MODEL1310110052#
is: SBO:0000185
kinetic law: MODEL1310110052#

metaR r2087
reversible: true
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110052#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_40ded9ce_be5b_40bd_a601_95855f635142
type: Species
is: E9PAK4
constant: false
initial concentration: NaN
name: SLC5A9
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:200010

metaR PMEVKx
type: Reaction
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000134
name: phosphomevalonate kinase
fast: false
modifier: MODEL1310110052#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.2
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.4.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ

metaM 34dhoxmand c
is: CHEBI:27637
has only substance units: false
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
name: 3,4-Dihydroxymandelate
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: HMDB01866
is: SBO:0000247
boundary condition: false

metaR NDPK9n
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: true
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM 2decdicoa m
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
name: 2,7-decadienoylcoa
constant: false
is: http://identifiers.org/pubchem.compound/16019966
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_7c20201b_78e7_47a3_b4b9_c462ec5ca369
initial concentration: NaN
is encoded by: hsa:5279
has part: P57054
is encoded by: hsa:5277
constant: false
is: SBO:0000297
has part: B2RAU6
is encoded by: hsa:51227
initial amount: NaN
has only substance units: false
type: Species
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:9091
boundary condition: true

metaM 4hoxpacd c
is: CHEBI:15621
is: HMDB03767
constant: false
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
name: (4-hydroxyphenyl)acetaldehyde

http://identifiers.org/biomodels.db/MODEL1310110052#_13163b3e_4893_4657_ad28_400ee80cf3d6
is: Q96E98
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
name: RHAG
boundary condition: true
is encoded by: hsa:6005

http://identifiers.org/biomodels.db/MODEL1310110052#_f584d246_4984_43aa_84fc_b00a9e5399c0
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is: O75438
boundary condition: true
initial concentration: NaN
name: NDUFB1
is encoded by: hsa:4707

metaR URATEt
is described by: ECO:0000000
reversible: false
is: SBO:0000185
name: urate export from cytosol
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
fast: false
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_db56e39d_027f_42cd_8071_d4e1b2cfef0c
is: A8K761
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:4716
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: NDUFB10
type: Species

metaM hexdiac r
initial concentration: 1.0
type: Species
constant: false
is: C08260
name: hexadecanediocacid
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00672
notes: FORMULA: C16H28O4 CHARGE: -2

metaM asp L c
initial concentration: 1.0
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
name: L-aspartate(1-)
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:29991
type: Species
is: HMDB00191
initial amount: NaN

metaR r2334
kinetic law: MODEL1310110052#
reversible: true
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR BILDGLCURtr
is described by: ECO:0000000
kinetic law: MODEL1310110052#
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110052#
product: MODEL1310110052#
name: glucuronidated compound transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ

metaM dd2coa m
initial amount: NaN
name: trans-dodec-2-enoyl-CoA(4-)
is: CHEBI:57330
type: Species
initial concentration: 1.0
is: HMDB03712
constant: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_67e8894d_d2c3_459d_b8f0_834f62cc24f9
initial amount: NaN
initial concentration: NaN
constant: false
name: _AI601100_1_m
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI601100
type: Species

metaR RTOTALt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110052#
name: RTOTAL transport

metaR VLCSr
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
modifier: MODEL1310110052#
is described by: ECO:0000269
product: MODEL1310110052#
fast: false
reversible: false
name: Very-long-chain-fatty-acid-CoA ligase
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110052#_674166d6_7ea9_4757_8b72_b2bc2dc579c6
name: FOLR1
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:2348

metaM mal L m
type: Species
has only substance units: false
constant: false
is: CHEBI:15589
boundary condition: false
is: HMDB00156
initial amount: NaN
name: (S)-malate(2-)
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146

metaR r0788
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#
modifier: MODEL1310110052#
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
reversible: true
is: SBO:0000176

metaM cl c
name: Chloride
is: SBO:0000247
boundary condition: false
is: C00115
is: HMDB00492
has only substance units: false
is: CHEBI:3966
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
notes: FORMULA: Cl CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110052#_95db8c34_24cc_4071_a546_eec84d0dee41
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6560
has only substance units: false
type: Species
name: SLC12A4
constant: false
initial concentration: NaN
is: F5H066

http://identifiers.org/biomodels.db/MODEL1310110052#_7c84d70e_a34c_4c91_95b7_75c466ebc822
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is: P25325
initial concentration: NaN
type: Species
is encoded by: hsa:4357
boundary condition: true
name: MPST

metaR r2120
kinetic law: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110052#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction

metaR r2088
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
product: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110052#
is described by: ECO:0000000

metaR r2333
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_fdfbbaab_1797_4d37_b5ec_9e64d489017a
is: Q9UFY1
name: PLCG1
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:5335

metaM cdp n
type: Species
initial concentration: 1.0
is: HMDB01546
is: CHEBI:58069
constant: false
name: CDP(3-)
has only substance units: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_14f9ce81_a2f9_416a_9f42_21e203360c84
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: GCK
is: Q53Y25
constant: false
has only substance units: false
is encoded by: hsa:2645

http://identifiers.org/biomodels.db/MODEL1310110052#_4140a6bb_e81e_402b_acd7_594ad85ec480
initial amount: NaN
is encoded by: hsa:10599
is: Q9Y6L6
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: SLCO1B1
constant: false
type: Species

metaR r0787
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.1
is: SBO:0000176
type: Reaction
product: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
is described by: ECO:0000000
modifier: MODEL1310110052#

metaM ei11ecoa x
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: 11-eicosenoylcoa
constant: false
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_0e01d3da_7d3e_44c8_b7ff_9bd3a76c6737
is: P15848
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: ARSB
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:411
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_518532f6_bec3_4710_99e0_130516cbb6d5
is: SBO:0000252
is encoded by: hsa:80271
name: ITPKC
initial concentration: NaN
is: Q96DU7
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false

metaR CYOOm3
modifier: MODEL1310110052#
name: cytochrome c oxidase, mitochondrial Complex IV
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
fast: false
is described by: ECO:0000134
reversible: false
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
is version of: http://identifiers.org/ec-code/1.9.3.1
is: SBO:0000185

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaM m2gacpail hs r
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
is: CHEBI:16038
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)
is: SBO:0000247
initial amount: NaN

metaR r2089
reversible: true
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110052#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

metaR r0236
is version of: http://identifiers.org/ec-code/3.5.1.6
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
modifier: MODEL1310110052#
reversible: true
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110052#_0529b1d5_e033_4a78_ab1f_3b297d9bf93d
is encoded by: hsa:F23536
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
name: _F23536_1_m
type: Species
has only substance units: false
is: SBO:0000252

metaM cdp m
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58069
is: HMDB01546
type: Species
boundary condition: false
has only substance units: false
constant: false
name: CDP(3-)

metaR r2332
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reactant: MODEL1310110052#
is: SBO:0000185
kinetic law: MODEL1310110052#

metaR FAOXC16C14m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C14)m
type: Reaction

metaR r0340
reactant: MODEL1310110052#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is: SBO:0000176
product: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.3.1.38
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110052#

metaR FAOXC102C101m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_3bdc0cef_3a15_4d3a_a61a_e5bae36245a1
has only substance units: false
is: SBO:0000252
constant: false
name: FUCA1
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:2517
initial concentration: NaN
is: P04066

metaM 2maacoa m
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
is: HMDB01157
initial concentration: 1.0
boundary condition: false
name: 2-methylacetoacetyl-CoA(4-)
is: SBO:0000247
is: CHEBI:57335
constant: false
initial amount: NaN
type: Species
has only substance units: false

metaM ribflv c
is: C00255
constant: false
name: Riboflavin
boundary condition: false
initial amount: NaN
is: CHEBI:3554
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: HMDB00244
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR GGT6
name: Gamma-glutamyltransferase
reversible: true
product: MODEL1310110052#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
type: Reaction

metaM dgtp c
type: Species
initial amount: NaN
name: dGTP
is: CHEBI:16497
boundary condition: false
is: HMDB01440
is: C00286
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286

metaR ORNt3m
kinetic law: MODEL1310110052#
type: Reaction
modifier: MODEL1310110052#
is: SBO:0000185
product: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
name: ornithine mitochondrial transport via proton antiport
is described by: ECO:0000269
reversible: true

metaR Q10H2e
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
is: SBO:0000185
fast: false
is described by: ECO:0000134
type: Reaction
product: MODEL1310110052#
reversible: true
kinetic law: MODEL1310110052#
name: transport of ubiquinol into lymph

metaR r0139
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reversible: true
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.2.2
product: MODEL1310110052#
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
modifier: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110052#_3b1d7784_85c7_4b02_9b4f_980e6378fc0c
name: PANK3
is: SBO:0000252
constant: false
is: Q9H999
initial concentration: NaN
type: Species
is encoded by: hsa:79646
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_d3e816ba_474a_451d_ae5c_5e489031d6b1
initial amount: NaN
is: P49915
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:8833
boundary condition: true
initial concentration: NaN
name: GMPS
has only substance units: false

metaM cbasp c
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
initial concentration: 1.0
is: HMDB00828
type: Species
is: C00438
is: CHEBI:32814
is: SBO:0000247
initial amount: NaN
constant: false
name: N-Carbamoyl-L-aspartate
has only substance units: false
boundary condition: false

metaR NACHEXA19ly
kinetic law: MODEL1310110052#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
fast: false
type: Reaction
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110052#
name: beta-N-acetylhexosaminidase A, lysosomal
modifier: MODEL1310110052#

metaR r0789
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
product: MODEL1310110052#

metaR HMGCOASi
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110052#
is: SBO:0000176
name: Hydroxymethylglutaryl CoA synthase (ir)
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: false
notes: GENE_ASSOCIATION: (3157.1) or (3157.2) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:1358203 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission Made irreversible to match KEGG data for S. aureus
is version of: http://identifiers.org/ec-code/2.3.3.10
fast: false
product: MODEL1310110052#

metaR G13MT L
modifier: MODEL1310110052#
name: Glycolipid 1,3-alpha-D-mannosyltransferase (liver)
is: SBO:0000176
product: MODEL1310110052#
reversible: false
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.132
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110052#
fast: false
type: Reaction

metaR r2331
product: MODEL1310110052#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110052#
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_6a14f80f_452c_41b7_bc62_53f6753f7ff9
constant: false
name: OXCT1
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P55809
type: Species
is encoded by: hsa:5019

metaR r1619
reversible: true
reactant: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110052#
fast: false
is described by: ECO:0000000

metaM lnlncgcoa r
constant: false
name: gamma-linolenoyl-CoA(4-)
boundary condition: false
is: SBO:0000247
is: CHEBI:57363
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
has only substance units: false
is: HMDB06368
initial concentration: 1.0
type: Species

metaR DOLPMT L
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
name: Dolichyl-phosphate D-mannosyltransferase (liver)
is version of: http://identifiers.org/ec-code/2.4.1.83
product: MODEL1310110052#
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
reversible: false
is: SBO:0000176
modifier: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
fast: false

metaR r0999
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is: SBO:0000185
product: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110052#
name: Facilitated diffusion
fast: false
kinetic law: MODEL1310110052#
reversible: true

metaR KSII CORE2t
kinetic law: MODEL1310110052#
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110052#
name: keratan sulfate II (core2) transport, golgi to extracellular
product: MODEL1310110052#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110052#_1bd40094_7a8f_4926_ad4f_b53d4a655f50
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: Q9H999
is encoded by: hsa:79646
is: SBO:0000252
initial amount: NaN
constant: false
name: PANK3

metaR MANtg
product: MODEL1310110052#
name: mannose efflux from Golgi apparatus
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false

metaM anth e
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB01123
is: CHEBI:16567
type: Species
initial concentration: 1.0
boundary condition: false
name: anthranilate
constant: false

metaR PYK
name: pyruvate kinase
reversible: false
fast: false
is: SBO:0000176
reactant: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.40
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_c612862c_4b77_4118_be4b_186f2913242a
name: UCK2
initial concentration: NaN
constant: false
is: Q9BZX2
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:7371

metaR IVCRNe
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of isovaleryl carnitine into the extra cellular space
type: Reaction

metaM co2 m
is: HMDB01967
type: Species
is: C00011
is: SBO:0000247
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial concentration: 1.0
name: CO2
has only substance units: false
boundary condition: false
is: CHEBI:16526
initial amount: NaN
constant: false

metaM cmp m
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species
is: HMDB00095
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:60377
name: CMP(2-)

metaM cala c
has only substance units: false
constant: false
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
name: N-carbamoyl-beta-alaninate
initial concentration: 1.0
is: HMDB00026
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:11892

metaR r2129
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
modifier: MODEL1310110052#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110052#
type: Reaction

metaR FRDPtcr
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110052#
type: Reaction
fast: false
reversible: true
product: MODEL1310110052#
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_4010fd07_77ea_4476_8034_94001942757e
is: SBO:0000252
is encoded by: hsa:4329
initial amount: NaN
has only substance units: false
is: Q02252
initial concentration: NaN
boundary condition: true
type: Species
constant: false
name: ALDH6A1

http://identifiers.org/biomodels.db/MODEL1310110052#_92e6cb15_9f7d_4b3b_a3e2_53aea4a57d52
initial amount: NaN
boundary condition: true
constant: false
is: Q9H2H9
is encoded by: hsa:81539
type: Species
is: SBO:0000252
name: SLC38A1
initial concentration: NaN
has only substance units: false

metaR HIBDm
kinetic law: MODEL1310110052#
is: SBO:0000176
product: MODEL1310110052#
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.1.31
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
reversible: true
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
modifier: MODEL1310110052#
fast: false
is described by: ECO:0000269
type: Reaction

metaR r0774
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
modifier: MODEL1310110052#
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
type: Reaction
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37

metaR r1618
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
fast: false
reactant: MODEL1310110052#

metaR ASPGLUm
reversible: true
fast: false
is: SBO:0000185
name: aspartate-glutamate mitochondrial shuttle
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (8604.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV

metaR r2352
is: SBO:0000185
reactant: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110052#

metaR FAOXC101C102m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_4786510d_127d_4527_b91d_5f51f1f6da8a
boundary condition: true
constant: false
type: Species
is: P24310
initial amount: NaN
name: COX7A1
is encoded by: hsa:1346
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR SBT Dtde
fast: false
product: MODEL1310110052#
reactant: MODEL1310110052#
reversible: true
kinetic law: MODEL1310110052#
name: D-sorbitol transport, extracellular
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
is described by: ECO:0000134
is: SBO:0000185

metaR FAOXC163Gm
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_c6b0f257_4a45_466b_9e87_609a99aa2934
is: B3KWF4
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:63917
has only substance units: false
is: SBO:0000252
name: GALNT11

http://identifiers.org/biomodels.db/MODEL1310110052#_a6325647_0087_4661_94a4_c1f96033c035
initial concentration: NaN
initial amount: NaN
is: O15382
is encoded by: hsa:587
has only substance units: false
name: BCAT2
constant: false
is: SBO:0000252
type: Species
boundary condition: true

metaM ksii core2 pre1 g
constant: false
is: CHEBI:28067
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: keratan sulfate II biosynthesis, precursor 1
notes: FORMULA: C33H53N3O23X CHARGE: -1
initial amount: NaN
has only substance units: false

metaR ILETAm
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.42
fast: false
product: MODEL1310110052#
name: isoleucine transaminase, mitochondrial
modifier: MODEL1310110052#
is: SBO:0000176
is described by: ECO:0000269

metaR C161CPT2
name: transport of Hexadecenoyl-CoA into mitochondrial matrix
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110052#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#

metaR LNLNCACRNt
reversible: false
reactant: MODEL1310110052#
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
product: MODEL1310110052#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000185

metaM sebcoa c
constant: false
name: sebacoylcoa
initial concentration: 1.0
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
is: HMDB00651
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR FAOXC16DCr
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

metaR FAS120COA
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD
reversible: false
name: fatty-acyl-CoA synthase (n-C12:0CoA)
reactant: MODEL1310110052#
product: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110052#

metaM ksi pre16 g
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 16
type: Species
is: CHEBI:58053
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: C00130
has only substance units: false

metaR UMPKn
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110052#
reactant: MODEL1310110052#
modifier: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#
name: UMP kinase, nuclear
is described by: ECO:0000269

metaM cit m
is: HMDB00094
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:16947
has only substance units: false
is: C00158
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: SBO:0000247
name: Citrate
constant: false

metaR DOLPMT2 Ler
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110052#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
kinetic law: MODEL1310110052#
reversible: false
is: SBO:0000176
reactant: MODEL1310110052#
fast: false
type: Reaction

metaM sgalside hs g
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
is: SBO:0000247
boundary condition: false
name: sulfatide galactocerebroside
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: HMDB00061
is: CHEBI:58343
has only substance units: false

metaR O2ter
reactant: MODEL1310110052#
name: O2 transport, endoplasmic reticulum
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
fast: false

metaM ribflv e
type: Species
name: Riboflavin
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: C00255
is: SBO:0000247
constant: false
is: CHEBI:3554
initial amount: NaN
is: HMDB00244
notes: FORMULA: C17H20N4O6 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110052#_61a3883b_e26e_4ce8_99a4_16b7053d0e1e
constant: false
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: Q9UG56
initial concentration: NaN
is encoded by: hsa:23761
name: PISD
is: SBO:0000252

metaR r2353
type: Reaction
name: Organic anion transporter 5 Utilized transport
reversible: true
kinetic law: MODEL1310110052#
is: SBO:0000185
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110052#
is described by: ECO:0000000
fast: false

metaM dhcholestanate c
has only substance units: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial concentration: 1.0
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
type: Species
is: CHEBI:16577
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00359
is: SBO:0000247

metaM drib c
initial amount: NaN
is: HMDB03224
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: 2-deoxy-D-ribose
type: Species
is: CHEBI:28816
boundary condition: false
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
constant: false

metaR MAN1PT2
is: SBO:0000176
is described by: ECO:0000000
name: mannose-1-phosphate guanylyltransferase (GDP)
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.7.13
modifier: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
reversible: false
reactant: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR

metaM 3sala m
initial amount: NaN
name: 3-sulfino-L-alanine (1-)
initial concentration: 1.0
is: CHEBI:61085
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
type: Species
is: C00606

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

metaM cdp c
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB01546
name: CDP
initial amount: NaN
is: C00112
boundary condition: false
constant: false
is: CHEBI:58069
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_966ba9cc_2b68_407e_a15c_e1263d1dc336
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
name: ACOT4
is: Q8N9L9
initial amount: NaN
type: Species
is encoded by: hsa:122970

metaR r0998
is: SBO:0000185
product: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#
name: Facilitated diffusion
fast: false
kinetic law: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaR r2354
product: MODEL1310110052#
fast: false
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110052#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_d9ea8b93_bab6_4bc7_9c78_860d5898dec8
is: Q9P212
initial concentration: NaN
is encoded by: hsa:51196
type: Species
has only substance units: false
is: SBO:0000252
constant: false
name: PLCE1
initial amount: NaN
boundary condition: true

metaM cmp n
is: CHEBI:60377
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00095
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial amount: NaN
name: CMP(2-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_1fc92d1b_cbfa_4047_b3fe_ce380ce354dc
initial amount: NaN
has only substance units: false
name: DGKE
constant: false
initial concentration: NaN
type: Species
is: A1L4Q0
is: SBO:0000252
is encoded by: hsa:8526
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_5d460f84_d71f_409e_8f25_604c94899ed4
boundary condition: true
is encoded by: hsa:27235
initial amount: NaN
constant: false
is: Q96H96
is: SBO:0000252
has only substance units: false
type: Species
name: COQ2
initial concentration: NaN

metaM arg L c
boundary condition: false
type: Species
name: L-argininium(1+)
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: CHEBI:32682
is: HMDB00517
is: SBO:0000247
has only substance units: false

metaM fprica c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
constant: false
has only substance units: false
type: Species
is: CHEBI:58467
is: HMDB01439
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
is: C04734
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_5831b834_8fe9_4753_a914_a222f1ba3a57
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:64077
constant: false
name: LHPP
is: Q9H008
has only substance units: false

metaR r1720
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
product: MODEL1310110052#
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
reversible: false
reactant: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR r0995
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000185
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaM drib e
boundary condition: false
is: HMDB03224
is: SBO:0000247
type: Species
is: CHEBI:28816
has only substance units: false
name: 2-deoxy-D-ribose
constant: false
initial concentration: 1.0
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
initial amount: NaN

metaR r2125
fast: false
reactant: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000000
modifier: MODEL1310110052#
reversible: true
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction

metaM n2m2nmn l
is: SBO:0000247
boundary condition: false
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
constant: false
type: Species
notes: FORMULA: C50H84N4O36 CHARGE: 0
initial concentration: 1.0
has only substance units: false
is: HMDB00742
is: CHEBI:17588
initial amount: NaN

metaR GULN3D
reversible: true
fast: false
kinetic law: MODEL1310110052#
is described by: ECO:0000000
name: L-gulonate 3-dehydrogenase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
product: MODEL1310110052#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110052#

metaM mal L c
initial concentration: 1.0
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
initial amount: NaN
type: Species
constant: false
is: HMDB00156
is: SBO:0000247
is: CHEBI:15589
name: (S)-malate(2-)
boundary condition: false
has only substance units: false

metaM cdp e
is: HMDB01546
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial concentration: 1.0
constant: false
is: CHEBI:58069
boundary condition: false
type: Species
name: CDP(3-)

metaR RE1521M
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
name: RE1521
type: Reaction
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM lnlncgcoa m
boundary condition: false
initial amount: NaN
is: CHEBI:57363
type: Species
is: SBO:0000247
constant: false
name: gamma-linolenoyl-CoA(4-)
initial concentration: 1.0
is: HMDB06368
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
has only substance units: false

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaM gdp e
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
is: HMDB01201
initial concentration: 1.0
boundary condition: false
name: GDP(3-)
type: Species
is: CHEBI:58189

metaR FADH2tx
fast: false
product: MODEL1310110052#
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
reactant: MODEL1310110052#
is: SBO:0000185
kinetic law: MODEL1310110052#
name: FADH2 transporter, peroxisomal

http://identifiers.org/biomodels.db/MODEL1310110052#_ef6e6307_ef14_4783_ba96_ee38deb0c95a
is: SBO:0000252
name: SLC25A26
constant: false
is encoded by: hsa:115286
type: Species
initial amount: NaN
boundary condition: true
is: Q70HW3
has only substance units: false
initial concentration: NaN

metaR r2126
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110052#
fast: false
reversible: true
reactant: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_a29af285_3839_4287_ae20_c2bd623ac368
initial amount: NaN
boundary condition: true
name: ALDH9A1
is: P49189
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:223
initial concentration: NaN

metaR r1722
is described by: ECO:0000000
type: Reaction
name: Y+LAT2 Utilized transport
product: MODEL1310110052#
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
reversible: false
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaR NDPK8n
fast: false
product: MODEL1310110052#
type: Reaction
reversible: true
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
is described by: ECO:0000304
modifier: MODEL1310110052#
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is: SBO:0000176

metaR HAtly
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110052#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
name: hyaluronan transport, extracellular to lysosome
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_a47cfa7b_70fe_49fc_bcd4_399289ebad33
is encoded by: hsa:6675
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: UAP1
is: Q16222
constant: false
boundary condition: true
type: Species

metaR HISSNAT5tc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM 4fumacac c
has only substance units: false
initial amount: NaN
name: 4-fumarylacetoacetate(2-)
type: Species
constant: false
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
boundary condition: false
initial concentration: 1.0
is: CHEBI:18034
is: HMDB01268
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_cc40924d_97c8_4faf_b096_beee57e3fbbe
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:5335
is: SBO:0000252
is: P19174
initial concentration: NaN
name: PLCG1

metaR C161CPT1
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:TDV
product: MODEL1310110052#
reversible: false
name: production of palmitoleoylcarnitine

metaM ksii core2 pre9 g
has only substance units: false
constant: false
name: keratan sulfate II biosynthesis, precursor 9
is: CHEBI:28067
initial amount: NaN
boundary condition: false
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
is: SBO:0000247
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_cb598acf_bf88_4bda_8403_ca7390dfc3cc
constant: false
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
name: CHAT
is encoded by: hsa:1103
initial amount: NaN
is: SBO:0000252
is: Q6LEN5

metaR OROTGLUt
is: SBO:0000185
fast: false
kinetic law: MODEL1310110052#
type: Reaction
name: OROTGLUt
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110052#

metaR r2127
product: MODEL1310110052#
reversible: true
modifier: MODEL1310110052#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#

metaR THRCYSNaEx
reversible: false
reactant: MODEL1310110052#
is: SBO:0000185
product: MODEL1310110052#
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-cysteine/L-threonine Na-dependent exchange (Thr-L in)

metaR r1721
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Y+LAT2 Utilized transport
type: Reaction
modifier: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
reversible: false
is described by: ECO:0000000

metaR r0443
type: Reaction
reversible: false
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.1.42
fast: false
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reactant: MODEL1310110052#
modifier: MODEL1310110052#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is described by: ECO:0000000
is: SBO:0000176

metaR SADT
is version of: http://identifiers.org/ec-code/2.7.1.25
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
name: sulfate adenylyltransferase
fast: false
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
reactant: MODEL1310110052#
reversible: false
product: MODEL1310110052#

metaM co2 r
name: CO2
boundary condition: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: C00011
type: Species
initial amount: NaN
is: HMDB01967
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:16526

metaM mal L e
is: HMDB00156
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
constant: false
is: CHEBI:15589
type: Species
has only substance units: false
is: SBO:0000247
name: (S)-malate(2-)
initial amount: NaN

metaR r0994
name: Facilitated diffusion
fast: false
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000185
reversible: true
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
is described by: ECO:0000000
type: Reaction

metaM phaccoa c
boundary condition: false
initial concentration: 1.0
is: HMDB06503
is: SBO:0000247
has only substance units: false
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
type: Species
initial amount: NaN
constant: false
name: phenylacetyl-CoA(4-)
is: CHEBI:57390

metaR FAOXC123m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

metaM xoltriol c
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:16496
is: SBO:0000247
type: Species
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
boundary condition: false
is: HMDB01457
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
initial amount: NaN

metaR EX c10crn
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_1b8768c6_112f_4ad6_9546_483534a6345c
initial amount: NaN
is: Q9NS00
initial concentration: NaN
is encoded by: hsa:56913
is: SBO:0000252
boundary condition: true
constant: false
name: C1GALT1
has only substance units: false
type: Species

metaM gdp g
type: Species
boundary condition: false
initial amount: NaN
name: GDP(3-)
has only substance units: false
is: HMDB01201
is: CHEBI:58189
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035

http://identifiers.org/biomodels.db/MODEL1310110052#_72d28899_a1e7_4c7e_8744_134a085df762
is: O94778
name: AQP8
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
is encoded by: hsa:343

metaR r2128
is: SBO:0000185
reversible: true
modifier: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR PROSTGH2t
reversible: true
kinetic law: MODEL1310110052#
is described by: ECO:0000269
is: SBO:0000185
name: Prostaglandin H2 transport
reactant: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
fast: false
type: Reaction

metaR CDSm
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
fast: false
product: MODEL1310110052#
name: phosphatidate cytidylyltransferase
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.7.41
kinetic law: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
modifier: MODEL1310110052#
type: Reaction

metaR THRASNNaEx
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
reversible: false
kinetic law: MODEL1310110052#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110052#
is: SBO:0000185
reactant: MODEL1310110052#
name: L-threonine/L-asparagine Na-dependent exchange (Thr-L in)

http://identifiers.org/biomodels.db/MODEL1310110052#_ac1f6a45_7b37_4fe2_876b_eb1648c4b7a3
initial amount: NaN
name: FUCA2
is encoded by: hsa:2519
is: Q9BTY2
type: Species
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR UDPGP
fast: false
is described by: ECO:0000000
name: UDPglucose pyrophosphohydrolase
is version of: http://identifiers.org/ec-code/3.1.4.39
notes: GENE_ASSOCIATION: (5167.1) or (5169.1) or (5168.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
reversible: false
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.4.1

http://identifiers.org/biomodels.db/MODEL1310110052#_1442e7c8_00e5_42ed_a41d_0b43f4c58846
is encoded by: hsa:271
type: Species
initial amount: NaN
is: B2RB47
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: AMPD2
has only substance units: false

metaR OMPDC
type: Reaction
product: MODEL1310110052#
is described by: ECO:0000269
kinetic law: MODEL1310110052#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.10
reversible: false
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
name: orotidine-5'-phosphate decarboxylase
fast: false
reactant: MODEL1310110052#
modifier: MODEL1310110052#

metaR HTDCACBP
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxytetradecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR r0339
type: Reaction
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is described by: ECO:0000000
reversible: false
product: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.22
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is version of: http://identifiers.org/ec-code/2.3.1.65

metaR r0660
kinetic law: MODEL1310110052#
reversible: true
is: SBO:0000176
type: Reaction
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
reactant: MODEL1310110052#
is described by: ECO:0000000
modifier: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_047b88ac_2151_44a0_89ac_87d89806dce9
name: ACAA1
is: Q96CA6
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:30
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_adf14752_7c5e_4ce8_9112_d57ca16a65f7
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
name: ELOVL2
is: Q9NXB9
has only substance units: false
is encoded by: hsa:54898
is: SBO:0000252
boundary condition: true

metaR r1611
product: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110052#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110052#_ef080b7a_1756_498b_8443_24251d1e432e
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10873
type: Species
name: ME3
is: Q6TCH8
boundary condition: true

metaR HSD3A1r
modifier: MODEL1310110052#
is described by: ECO:0000269
type: Reaction
fast: false
product: MODEL1310110052#
kinetic law: MODEL1310110052#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
reversible: true
is: SBO:0000176
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.1.225
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ

http://identifiers.org/biomodels.db/MODEL1310110052#_51a78177_c77c_4595_a727_7b27dc54028d
boundary condition: true
initial amount: NaN
constant: false
name: FDFT1
is: P37268
initial concentration: NaN
is encoded by: hsa:2222
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_32079659_ba08_4a84_b444_a1ce67df0306
initial amount: NaN
name: ALDOA
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:226

metaM lpro m
notes: FORMULA: S2X CHARGE: 0 EHMN_ABBREVIATION: C02051
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: Lipoylprotein
boundary condition: false
is: CHEBI:15804

http://identifiers.org/biomodels.db/MODEL1310110052#_d3dafc80_942b_4960_9185_96e579ec5792
is: SBO:0000252
constant: false
has only substance units: false
name: ACSL5
is encoded by: hsa:51703
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is: Q9ULC5

metaM lgnccoa x
type: Species
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
name: lignocericyl coenzyme A
initial concentration: 1.0
has only substance units: false
is: HMDB06526
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN

metaR OCTDECE1CRNe
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-octadecenoyl carnitine into extra cellular space
type: Reaction

metaR r1610
reactant: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110052#_be126b9b_0fed_474e_8ec0_b19785d30b33
is: SBO:0000252
initial amount: NaN
is: Q9NYQ3
constant: false
has only substance units: false
initial concentration: NaN
name: HAO2
type: Species
boundary condition: true
is encoded by: hsa:51179

metaR RE3003M
type: Reaction
name: RE3003
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
is: SBO:0000176
fast: false
product: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110052#

metaR SPRMS
fast: false
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.5.1.22
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6611.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.22 Confidence Level: 4 AUTHORS: PMID:7546290 NOTES:NCD
type: Reaction
is: SBO:0000176
reversible: false
name: spermine synthase
product: MODEL1310110052#
reactant: MODEL1310110052#
modifier: MODEL1310110052#

metaM CE5786 e
is: CHEBI:27485
initial amount: NaN
name: kinetensin
is: HMDB02710
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
boundary condition: false
initial concentration: 1.0
type: Species

metaR EX c81crn
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octenoyl carnitine
type: Reaction

metaR CLOXAtex2
reactant: MODEL1310110052#
is: SBO:0000185
product: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
name: chloride transport via oxalate countertransport (2:1)
reversible: false
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
kinetic law: MODEL1310110052#
is described by: ECO:0000304
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_9e46b6f3_feeb_4dec_9ec4_a0858fe46cd3
is encoded by: hsa:4695
has only substance units: false
is: O43678
constant: false
type: Species
name: NDUFA2
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM chtn e
boundary condition: false
notes: FORMULA: C24H41N3O16 CHARGE: 0 INCHI: InChI=1S/C24H41N3O16/c1-7(31)25-13-18(36)20(11(5-29)39-22(13)38)42-24-15(27-9(3)33)19(37)21(12(6-30)41-24)43-23-14(26-8(2)32)17(35)16(34)10(4-28)40-23/h10-24,28-30,34-38H,4-6H2,1-3H3,(H,25,31)(H,26,32)(H,27,33)/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+,24+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02118
constant: false
name: chitin
has only substance units: false
is: CHEBI:17029
is: SBO:0000247
initial amount: NaN
is: HMDB03362
type: Species
initial concentration: 1.0

metaM cit e
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00094
name: citrate(3-)
is: SBO:0000247
type: Species
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: CHEBI:16947
has only substance units: false
boundary condition: false

metaR PLA2 2e
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (5322.1) or (5319.1) or (81579.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (30814.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:10455175,PMID:10681567,PMID:11031251,PMID:11112443,PMID:8300559,PMID:9188469,PMID:9272153,PMID:9886417 NOTES:phosphatidyl choline degradation NJ
reactant: MODEL1310110052#
name: phospholipase A2
is: SBO:0000176
modifier: MODEL1310110052#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.4
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_769a9c1b_9f71_4c36_89eb_e4b6aea28992
initial concentration: NaN
is encoded by: hsa:1606
name: DGKA
is: P23743
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252

metaR r1613
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110052#
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110052#
reversible: true
is: SBO:0000185

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_84cf547c_1c16_4c03_b65a_38f709da07a3
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: MTMR3
type: Species
is: SBO:0000252
is encoded by: hsa:8897

metaR BTNt2
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110052#
name: Biotin reversible transport via proton symport
type: Reaction
product: MODEL1310110052#
modifier: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000185

metaR G14T16g
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
reversible: false
product: MODEL1310110052#
reactant: MODEL1310110052#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.22

metaR r0885
product: MODEL1310110052#
modifier: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.3.1.38
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_f1ca9cd9_f414_40c1_b8cd_b270fff3c934
is: P19634
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:6548
constant: false
boundary condition: true
has only substance units: false
name: SLC9A1

metaR r0552
is version of: http://identifiers.org/ec-code/1.3.5.1
type: Reaction
reactant: MODEL1310110052#
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
fast: false
reversible: true
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#
is: SBO:0000176

metaR r1612
kinetic law: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110052#
reactant: MODEL1310110052#
modifier: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_9a84fe32_d9f1_4ca0_822f_3b3017435937
is encoded by: hsa:476
is encoded by: hsa:483
initial concentration: NaN
has only substance units: false
name: ATP1A1:ATP1B3
is: SBO:0000297
has part: P54709
initial amount: NaN
has part: B7Z3U6
boundary condition: true
type: Species
constant: false

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaR DDPGAm
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
reversible: true
product: MODEL1310110052#
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
kinetic law: MODEL1310110052#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_54d2437b_312c_494e_8ff3_663370e881e0
name: SLC24A4
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false
is: Q8NFF2
has only substance units: false
is encoded by: hsa:123041

http://identifiers.org/biomodels.db/MODEL1310110052#_adc8b124_056f_4a14_9b39_ca8685fbc5a1
has only substance units: false
is encoded by: hsa:222
constant: false
initial amount: NaN
is: P48448
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: ALDH3B2

metaM cit c
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: C00158
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00094
is: CHEBI:16947
type: Species
name: Citrate

metaM eicostet c
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H31O2 CHARGE: -1
is: CHEBI:36033
is: HMDB02177
name: eicosatetranoic acid
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247

metaM ser D c
is: SBO:0000247
name: D-serine
boundary condition: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: CHEBI:16523
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: HMDB03406

metaR r0553
type: Reaction
product: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
fast: false
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_9736bf95_9bee_4ff2_96f0_712623d772f9
name: DHCR24
is encoded by: hsa:1718
is: SBO:0000252
is: Q15392
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR AG13T18g
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110052#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
kinetic law: MODEL1310110052#
is: SBO:0000176
modifier: MODEL1310110052#
reactant: MODEL1310110052#

metaM dhcholestanate m
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
initial amount: NaN
is: CHEBI:16577
has only substance units: false
type: Species
initial concentration: 1.0
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00359

metaR r1615
reactant: MODEL1310110052#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110052#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR NACHEXA13ly
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110052#
reversible: false
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
name: beta-N-acetylhexosaminidase A, lysosomal
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
product: MODEL1310110052#

metaR r1728
is described by: ECO:0000000
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
modifier: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
fast: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_86149de6_5a3b_4d86_bf8c_03c1911d80cc
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:AI934540
is: SBO:0000252
type: Species
name: _AI934540_1_c
initial concentration: NaN
has only substance units: false

metaM HC01405 m
is: SBO:0000247
name: (S)-Hydroxyoctanoyl-CoA
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
type: Species
boundary condition: false
is: CHEBI:28632

metaM arg L e
is: CHEBI:32682
is: HMDB00517
is: SBO:0000247
type: Species
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
name: L-argininium(1+)
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_5deb2b46_d482_4f76_9bf3_21292cfff488
name: _D29675_1_c
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:D29675
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false

metaR S4TASE2ly
is version of: http://identifiers.org/ec-code/3.1.6.12
reversible: true
fast: false
reactant: MODEL1310110052#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
product: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
modifier: MODEL1310110052#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110052#_886c526e_b0fe_403d_9057_a05b96ba686b
is: SBO:0000252
is: Q6IA69
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:55191
has only substance units: false
boundary condition: true
name: NADSYN1

metaM gdp m
initial amount: NaN
name: GDP
has only substance units: false
is: HMDB01201
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
is: C00035
is: CHEBI:58189
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_436079cb_c167_4dd8_a3ff_0d505f25b4ce
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
name: PDE11A
is: Q9HCR9
is: SBO:0000252
type: Species
is encoded by: hsa:50940

metaR EX oxa LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

metaR RE1804C
is: SBO:0000176
kinetic law: MODEL1310110052#
type: Reaction
fast: false
reversible: true
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
name: RE1804
is described by: ECO:0000000
reactant: MODEL1310110052#

metaM hexdiac c
initial concentration: 1.0
type: Species
name: hexadecanediocacid
has only substance units: false
boundary condition: false
is: C08260
is: SBO:0000247
initial amount: NaN
is: HMDB00672
constant: false
notes: FORMULA: C16H28O4 CHARGE: -2

metaR r1614
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110052#
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110052#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
modifier: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_3b49a13d_eb6c_48b2_9433_a2f11fde97f0
is: A8K4A0
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ARSB
constant: false
type: Species
is encoded by: hsa:411

http://identifiers.org/biomodels.db/MODEL1310110052#_21306b6e_389c_42e3_adf3_ef5ccdd1b0da
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:123041
name: SLC24A4

metaM co2 x
type: Species
is: SBO:0000247
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01967
is: CHEBI:16526
name: carbon dioxide
constant: false

metaM eicostet e
is: HMDB02177
is: CHEBI:36033
boundary condition: false
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1
name: eicosatetranoic acid
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_10326746_6da0_4b9a_ab88_62b3427d92ba
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
boundary condition: true
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:498
initial amount: NaN
is: SBO:0000297
has part: B4DY56

http://identifiers.org/biomodels.db/MODEL1310110052#_f5753985_736c_47dc_8237_ea8b5c4f4463
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5151
has only substance units: false
initial amount: NaN
name: PDE8A

metaR r1302
fast: false
product: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: Vesicular transport
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#

metaM gdp n
constant: false
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB01201
initial concentration: 1.0
name: GDP(3-)
initial amount: NaN
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: CHEBI:58189
has only substance units: false

metaM ser D e
constant: false
boundary condition: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: HMDB03406
has only substance units: false
initial amount: NaN
name: D-serine
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16523
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_25a6c3ea_1a40_4a2c_9173_07bc7fd25ee7
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ACOT6
type: Species
has only substance units: false
is: Q3I5F7
is encoded by: hsa:641372
constant: false

metaR DCSPTN1COAtx
reversible: true
name: fatty acid intracellular transport
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_540b0d98_eb4e_4f76_9ce1_179338b66ff0
name: SULT1A2
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:6799
boundary condition: true
is: SBO:0000252

metaM anth c
boundary condition: false
is: CHEBI:16567
constant: false
has only substance units: false
name: anthranilate
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
is: HMDB01123
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaM sgalside hs c
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
initial amount: NaN
is: CHEBI:16523
is: SBO:0000247
is: HMDB03406
boundary condition: false
constant: false
name: sulfatide galactocerebroside
type: Species
has only substance units: false
initial concentration: 1.0

metaM xoltriol m
constant: false
is: CHEBI:16496
has only substance units: false
type: Species
initial concentration: 1.0
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
is: HMDB01457

metaR r1617
type: Reaction
is: SBO:0000185
reversible: true
modifier: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110052#_bfee2b5c_128d_4217_b7cf_cc85def7c550
is: P48735
type: Species
initial concentration: NaN
name: IDH2
boundary condition: true
constant: false
is encoded by: hsa:3418
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR r1301
reversible: false
reactant: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
name: Vesicular transport

http://identifiers.org/biomodels.db/MODEL1310110052#_0a85815e_f2a1_4e9c_ae2d_f6a2fa940619
is: Q5T4Y1
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ST3GAL3
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:6487

metaR PIter
fast: false
is described by: ECO:0000212
kinetic law: MODEL1310110052#
name: phosphate transport, endoplasmic reticulum
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
reversible: true
modifier: MODEL1310110052#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110052#

metaR PMANM
reactant: MODEL1310110052#
is: SBO:0000176
modifier: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.2.2
is version of: http://identifiers.org/ec-code/5.4.2.8
product: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110052#
name: phosphomannomutase

metaM glc D r
is: HMDB00122
is: SBO:0000247
name: D-glucose
is: CHEBI:4167
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040

http://identifiers.org/biomodels.db/MODEL1310110052#_0d531768_13b6_4ccd_8bd7_7b0c41a4cb46
is: F8WAB8
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
name: SLC25A26
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:115286

metaR r1527
is: SBO:0000185
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
fast: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
modifier: MODEL1310110052#
reversible: false
reactant: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.1
kinetic law: MODEL1310110052#
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_8d25dcc5_2dba_48b3_b807_4871fe5b8a65
is: P30837
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: ALDH1B1
initial concentration: NaN
is encoded by: hsa:219
is: SBO:0000252
constant: false

metaR EX c16dc
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecanedioic acid mono-L-carnitine ester
type: Reaction

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaR r0556
type: Reaction
reversible: true
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
is version of: http://identifiers.org/ec-code/1.14.19.1
fast: false
modifier: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#

metaR r1616
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
modifier: MODEL1310110052#

metaR r0558
is version of: http://identifiers.org/ec-code/1.5.1.3
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
modifier: MODEL1310110052#
reversible: true
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110052#_c417df41_fc5e_4d63_92be_e85ab9bc06ff
constant: false
initial amount: NaN
initial concentration: NaN
name: ACAT1
boundary condition: true
is encoded by: hsa:38
type: Species
is: P24752
is: SBO:0000252
has only substance units: false

metaM odecrn m
name: octadecenoyl carnitine
constant: false
is: SBO:0000247
is: HMDB01114
initial amount: NaN
has only substance units: false
is: C00412
is: CHEBI:57394
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
boundary condition: false
initial concentration: 1.0
type: Species

metaM idour e
is: HMDB02704
type: Species
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
name: L-iduronate
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:21338

metaR r0669
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000000
reversible: false
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
reactant: MODEL1310110052#

metaR PI3P4Kn
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:NCD FULLR corresponds to acyl/R groups in texts. NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
is: SBO:0000176
name: phosphatidylinositol 3-phosphate 4-kinase, nuclear
product: MODEL1310110052#
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_ad8ce865_94d4_4685_9751_63af11458a05
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: Q9UKG4
name: SLC13A4
is: SBO:0000252
constant: false
is encoded by: hsa:26266
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_084bc617_3d56_42d1_902e_3adc19b8a973
boundary condition: true
name: GALNT7
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:51809
is: Q86SF2
is: SBO:0000252
initial amount: NaN

metaM retinal cis 9 c
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
is: CHEBI:17898
has only substance units: false
constant: false
name: all-trans-retinal
initial concentration: 1.0
is: HMDB01358

http://identifiers.org/biomodels.db/MODEL1310110052#_08071358_683b_458b_a4eb_3acc206fcefb
is: P09172
type: Species
is encoded by: hsa:1621
is: SBO:0000252
constant: false
name: DBH
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN

metaR FUMAC
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.7.1.2
reversible: false
name: fumarylacetoacetase
fast: false
product: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD

metaR 10FTHFtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
kinetic law: MODEL1310110052#
reversible: true
is described by: ECO:0000000
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
product: MODEL1310110052#
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_f446a7b0_1033_46a4_bcad_5e5062b9b5dd
boundary condition: true
is: SBO:0000252
name: SLC25A15
is: Q9Y619
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:10166
type: Species
constant: false

metaM atp n
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
name: ATP(3-)
is: HMDB00538
constant: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
is: SBO:0000247
is: CHEBI:57299

metaR RE3520E
name: RE3520
is: SBO:0000176
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
is version of: http://identifiers.org/ec-code/1.11.1.9
reactant: MODEL1310110052#
modifier: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110052#
fast: false
product: MODEL1310110052#

metaR COAtg
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: true
fast: false
name: CoA transport in Golgi via diffusion
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaM hexdtrcoa m
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: HMDB02288
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: 7,10,13-hexadecatrienoylcoa
type: Species
is: SBO:0000247

metaM phyt2ohcoa x
is: CHEBI:57334
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)32(50)40(54)70-20-19-43-30(49)17-18-44-38(53)35(52)41(6,7)22-63-69(60,61)66-68(58,59)62-21-29-34(65-67(55,56)57)33(51)39(64-29)48-24-47-31-36(42)45-23-46-37(31)48/h23-29,32-35,39,50-52H,8-22H2,1-7H3,(H,43,49)(H,44,53)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/t26?,27?,28?,29-,32?,33-,34-,35+,39-/m1/s1 EHMN_ABBREVIATION: C07343
constant: false
is: HMDB01295
name: 2-hydroxyphytanoyl-CoA(4-)
initial amount: NaN
boundary condition: false
has only substance units: false

metaR r0668
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.19
fast: false
reversible: true
reactant: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110052#_9fe4507b_1949_42bc_b11c_231ca2aa08fc
type: Species
name: SLC6A6
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6533
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q9BRI2

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaR FAOXC5C3x
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_910a1cb7_fcf5_4511_a1f2_1d57666ecdf0
constant: false
is encoded by: hsa:23305
boundary condition: true
is: B2RB13
has only substance units: false
initial amount: NaN
name: ACSL6
type: Species
initial concentration: NaN
is: SBO:0000252

metaM cs e deg1 l
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
has only substance units: false
constant: false
is: HMDB00868
type: Species
is: CHEBI:57737
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C45H65N2O52S5 CHARGE: -7

metaM acnamp c
is: SBO:0000247
is: HMDB06268
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:27438
initial concentration: 1.0
notes: FORMULA: C11H17NO12P CHARGE: -3 INCHI: InChI=1S/C11H20NO12P/c1-4(13)12-7-5(14)2-11(19,10(17)18)24-9(7)8(16)6(15)3-23-25(20,21)22/h5-9,14-16,19H,2-3H2,1H3,(H,12,13)(H,17,18)(H2,20,21,22)/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01734 EHMN_ABBREVIATION: C06241
constant: false
name: N-Acetylneuraminate 9-phosphate

metaR GLCter
name: glucose transport, endoplasmic reticulum
type: Reaction
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
reactant: MODEL1310110052#
reversible: true
fast: false
product: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110052#_4216cdc6_8e22_4a64_a7d7_6d3c021ab540
boundary condition: true
is: SBO:0000252
is: P48735
constant: false
has only substance units: false
initial concentration: NaN
type: Species
name: IDH2
is encoded by: hsa:3418
initial amount: NaN

metaM udp r
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial amount: NaN
is: CHEBI:58223
is: SBO:0000247
name: UDP
has only substance units: false
initial concentration: 1.0
is: HMDB00295
constant: false
is: C00015
type: Species
boundary condition: false

metaM xol27oh r
type: Species
is: SBO:0000247
name: 26-hydroxycholesterol
initial amount: NaN
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: HMDB02103
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:17703

metaM 3hddcoa m
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: (S)-3-Hydroxydodecanoyl-CoA
constant: false
is: HMDB03952
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
initial concentration: 1.0
is: C05280
type: Species

metaR SFCYSc
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID: 2621485 NOTES:non-enzymatic reaction. Sulfocysteine is excreted in the urine.One proton added for elemental balancing.
reactant: MODEL1310110052#
name: Formation of sulfocysteine
is: SBO:0000176
kinetic law: MODEL1310110052#
reversible: true
is described by: ECO:0000134
fast: false
type: Reaction
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_745fb100_185e_4b9f_b8eb_b31731e2ed8d
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is: P13804
initial amount: NaN
is encoded by: hsa:2108
name: ETFA

http://identifiers.org/biomodels.db/MODEL1310110052#_b908fd87_d1b1_46bf_baa7_82b6c6c43cd2
initial concentration: NaN
constant: false
is encoded by: hsa:H77542
is: SBO:0000252
name: _H77542_1_r
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true

metaR KYNAKGAT
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.64
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
is version of: http://identifiers.org/ec-code/2.6.1.7
product: MODEL1310110052#
reversible: false
is described by: ECO:0000269
name: L-Kynurenine:2-oxoglutarate aminotransferase
is: SBO:0000176
modifier: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_aaf15ecd_a388_49aa_bd3a_397a9ed33c3b
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6487
type: Species
name: ST3GAL3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_938f3e92_b51d_4b6f_8251_16e6a88e1844
boundary condition: true
is: P48764
is: SBO:0000252
is encoded by: hsa:6550
constant: false
name: SLC9A3
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN

metaM idour c
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
boundary condition: false
name: L-iduronate
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB02704
is: CHEBI:21338
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_8f07277c_e786_40dc_99ee_99166c6b7a5d
is: Q6ZWP6
initial concentration: NaN
is: SBO:0000252
type: Species
name: ACAD8
constant: false
initial amount: NaN
is encoded by: hsa:27034
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_08db6786_675f_4f4c_9f73_2e9ef4c4a26a
constant: false
name: PIP4K2C
is: B3KQV3
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:79837
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR r0559
reactant: MODEL1310110052#
product: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
kinetic law: MODEL1310110052#
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3
type: Reaction
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1

metaM CE4876 r
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
name: delta12-Prostaglandin J2
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57923

metaM aps c
is: SBO:0000247
type: Species
constant: false
is: CHEBI:58243
has only substance units: false
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
is: HMDB01003
name: 5'-adenylyl sulfate(2-)
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR CERT2rt
fast: false
is: SBO:0000185
reactant: MODEL1310110052#
is described by: ECO:0000000
reversible: true
type: Reaction
name: ceramide transport protein
product: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110052#

metaR FTHFL
modifier: MODEL1310110052#
name: Formate-tetrahydrofolate ligase
is version of: http://identifiers.org/ec-code/1.5.1.5
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110052#
reversible: true
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000176

metaM pydx5p c
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:597326
initial amount: NaN
notes: FORMULA: C8H8NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
initial concentration: 1.0
is: SBO:0000247
is: HMDB01491
is: C00018
name: Pyridoxal 5'-phosphate
constant: false

metaR r0145
is version of: http://identifiers.org/ec-code/1.8.3.1
reactant: MODEL1310110052#
modifier: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
type: Reaction
kinetic law: MODEL1310110052#
reversible: true
is: SBO:0000176
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39

http://identifiers.org/biomodels.db/MODEL1310110052#_0169e92a_8810_4902_96b4_2b9e976b7fa9
is: Q16348
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6565
constant: false
has only substance units: false
name: SLC15A2
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_7321bf6c_c580_4198_a547_bbc51e1239b1
is: P12235
is encoded by: hsa:291
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
boundary condition: true
initial amount: NaN
name: SLC25A4

metaR FAOXC2452256x
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
reactant: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:5,n-6 -> c22:5, n-6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
product: MODEL1310110052#

metaM nrvnc c
is: CHEBI:32392
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
initial concentration: 1.0
is: HMDB02368
has only substance units: false
boundary condition: false
name: nervonate
type: Species

metaM 3hexdtetcoa m
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
boundary condition: false
constant: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: 3,7,10,13-hexadecatetraenoylcoa
is: HMDB02288

http://identifiers.org/biomodels.db/MODEL1310110052#_ad7eb411_415a_4302_9ff8_66fd120d9142
initial amount: NaN
name: SLC38A4
constant: false
is encoded by: hsa:55089
is: SBO:0000252
type: Species
is: Q969I6
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR SFCYSe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 2621485 NOTES:sulfocysteine is exfreted in urine
reactant: MODEL1310110052#
is: SBO:0000185
is described by: ECO:0000134
fast: false
reversible: true
kinetic law: MODEL1310110052#
name: Exit of sulfocysteine into extra-cellular space
type: Reaction
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_2417e0a3_e1ef_4506_9e36_84265e169720
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q6IBB5
is: SBO:0000252
is encoded by: hsa:4694
constant: false
type: Species
initial amount: NaN
name: NDUFA1

metaR DOLGPP Ler
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (liver)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
product: MODEL1310110052#
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110052#
reversible: false
kinetic law: MODEL1310110052#

metaR BAMPPALDOX
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/1.2.1.36
reactant: MODEL1310110052#
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
kinetic law: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
modifier: MODEL1310110052#
reversible: false
fast: false

metaM CE1926 e
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:15748
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00127
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
initial amount: NaN
name: gama-carboxyethyl-hydroxychroman

http://identifiers.org/biomodels.db/MODEL1310110052#_ac4725cb_1763_47c4_8a5f_8a49e31158fd
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q9UJ70
boundary condition: true
is encoded by: hsa:55577
initial amount: NaN
constant: false
name: NAGK

metaR AMPDA
reactant: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/3.5.4.6
is described by: ECO:0000269
is: SBO:0000176
name: Adenosine monophosphate deaminase
modifier: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
product: MODEL1310110052#

metaM arg L m
type: Species
boundary condition: false
name: L-argininium(1+)
is: CHEBI:32682
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00517
constant: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_fe95ec7a_da31_4598_ad1e_35c945462cb7
has only substance units: false
is encoded by: hsa:3038
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
name: HAS3
is: Q96RV2

metaR EX ptth LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ptth
type: Reaction

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaM dgmp e
has only substance units: false
is: SBO:0000247
is: CHEBI:57673
boundary condition: false
initial concentration: 1.0
name: dGMP(2-)
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
constant: false
initial amount: NaN
type: Species
is: HMDB01044

http://identifiers.org/biomodels.db/MODEL1310110052#_1b3758b1_89c7_45c5_be0f_a9b8f0eb0e87
has only substance units: false
name: ETFA:ETFB
type: Species
is: SBO:0000297
initial concentration: NaN
boundary condition: true
has part: P38117
is encoded by: hsa:2109
constant: false
initial amount: NaN

metaM glyc e
is: CHEBI:17754
is: HMDB00131
name: Glycerol
is: C00116
initial amount: NaN
type: Species
constant: false
boundary condition: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM HC00361 c
constant: false
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:58335
has only substance units: false
initial concentration: 1.0
name: sedoheptulose 1,7-bisphosphate(4-)

http://identifiers.org/biomodels.db/MODEL1310110052#_2f31a96f_58f2_4dfc_bf44_0225d72bfc22
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
name: ADCY1
is encoded by: hsa:107
is: Q08828
is: SBO:0000252
constant: false
initial amount: NaN

metaM 2dp6mobq me m
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: 2-decaprenyl-6-methoxy-3-methyl-1,4-benzoquinone
notes: FORMULA: C58H88O3 CHARGE: 0 INCHI: InChI=1S/C58H88O3/c1-44(2)23-14-24-45(3)25-15-26-46(4)27-16-28-47(5)29-17-30-48(6)31-18-32-49(7)33-19-34-50(8)35-20-36-51(9)37-21-38-52(10)39-22-40-53(11)41-42-55-54(12)56(59)43-57(61-13)58(55)60/h23,25,27,29,31,33,35,37,39,41,43H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+,53-41+
boundary condition: false
is: CHEBI:50772
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_9894e787_4820_4cb9_ac45_a6b7848d6135
is encoded by: hsa:400410
constant: false
is: SBO:0000252
has only substance units: false
name: ST20
initial concentration: NaN
boundary condition: true
is: Q9HBF5
initial amount: NaN
type: Species

metaM ncam c
type: Species
is: CHEBI:0
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
is: C00153
initial concentration: 1.0
is: HMDB01406
notes: FORMULA: C6H6N2O CHARGE: 0
boundary condition: false
name: Nicotinamide

http://identifiers.org/biomodels.db/MODEL1310110052#_3ee545d2_ee10_4463_8ee7_45a1e127d5f8
initial concentration: NaN
type: Species
initial amount: NaN
is: O76074
is encoded by: hsa:8654
boundary condition: true
name: PDE5A
has only substance units: false
is: SBO:0000252
constant: false

metaM pydx5p e
name: pyridoxal 5'-phosphate(2-)
notes: FORMULA: C8H8NO6P CHARGE: -2 INCHI: InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)/p-2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB01491
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:597326

metaM nrpphrsf e
type: Species
initial concentration: 1.0
name: Sulfate derivative of norepinephrine
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/123747
has only substance units: false
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
initial amount: NaN
boundary condition: false
is: HMDB02062

metaM 3sala c
constant: false
is: C00606
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:61085
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
name: 3-Sulfino-L-alanine
boundary condition: false
initial amount: NaN

metaR EX 3tetd7ecoacrn
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy tetradecenoyl-7-carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_7ba2f087_c7b9_4f38_af11_249e57227477
boundary condition: true
initial amount: NaN
type: Species
constant: false
is: Q06055
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ATP5G2
is encoded by: hsa:517

metaM nrvnc e
has only substance units: false
is: SBO:0000247
is: CHEBI:32392
initial amount: NaN
constant: false
is: HMDB02368
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
initial concentration: 1.0
type: Species
boundary condition: false
name: nervonate

metaR NADPHtxu
reversible: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ free hydrogens NJ
fast: false
kinetic law: MODEL1310110052#
name: NADPH transporter, peroxisome
product: MODEL1310110052#

metaR UDPGD
product: MODEL1310110052#
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.1.22
name: UDPglucose 6-dehydrogenase
fast: false
reversible: false
notes: GENE_ASSOCIATION: (7358.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 1.1.1.22 Confidence Level: 2 AUTHORS: PMID:9296457,PMID:9737970 NOTES:JLR
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110052#
is described by: ECO:0000304
modifier: MODEL1310110052#

metaR NDP8
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.4.9
reversible: false
type: Reaction
is: SBO:0000176
name: nucleoside-diphosphatase (dUDP)
fast: false
reactant: MODEL1310110052#
is described by: ECO:0000269
product: MODEL1310110052#

metaR r0881
fast: false
name: Active transport
reactant: MODEL1310110052#
is: SBO:0000185
product: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
type: Reaction
is described by: ECO:0000000

metaR RE1804M
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110052#
name: RE1804
modifier: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#

metaR COAtl
reactant: MODEL1310110052#
fast: false
name: CoA transport in lysosome via diffusion
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110052#

metaR TTDCPT2
type: Reaction
reactant: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
name: carnitine transferase
kinetic law: MODEL1310110052#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110052#

metaR r0142
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: false
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
product: MODEL1310110052#
reactant: MODEL1310110052#

metaM C05957 r
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: HMDB02710
name: Prostaglandin J2
is: CHEBI:27485

metaM sebcoa x
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
has only substance units: false
boundary condition: false
type: Species
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
name: sebacoylcoa
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110052#_6a86f18f_94c5_4f3d_95d5_ec3d8a4defbe
is: SBO:0000252
name: _R06874_1_r
constant: false
type: Species
boundary condition: true
is encoded by: hsa:R06874
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_b82b6ce0_c85a_445f_ab4b_cbfa8bf3d923
name: SCD
type: Species
initial amount: NaN
is encoded by: hsa:6319
boundary condition: true
is: O00767
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_b6c82985_150d_44b9_8bb0_725956d48886
is encoded by: hsa:376497
type: Species
has only substance units: false
is: Q6PCB7
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: SLC27A1

metaR COAtm
product: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
name: CoA transporter
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
is described by: ECO:0000269

metaM atp m
initial concentration: 1.0
boundary condition: false
is: C00002
has only substance units: false
name: ATP(4-)
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:57299
is: HMDB00538
constant: false

metaM ncam e
has only substance units: false
initial amount: NaN
is: CHEBI:0
boundary condition: false
name: Nicotinamide
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C6H6N2O CHARGE: 0
is: C00153
is: HMDB01406

metaR C4x
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of butyrylcoa to butyrylcarnitine for transport
type: Reaction

metaM CE5586 c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
constant: false
type: Species
is: SBO:0000247
is: CHEBI:58732

metaM nrpphrsf c
is: HMDB02062
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/123747
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
boundary condition: false
name: Sulfate derivative of norepinephrine
type: Species

metaM homoval m
initial concentration: 1.0
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
has only substance units: false
is: HMDB00118
name: Homovanillate
is: SBO:0000247
type: Species
is: CHEBI:545959
initial amount: NaN
constant: false
boundary condition: false

metaM HC01231 c
constant: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
initial concentration: 1.0
boundary condition: false
is: CHEBI:58480
initial amount: NaN
type: Species
is: SBO:0000247
name: N-[(R)-pantothenoyl]-L-cysteinate
has only substance units: false

metaM glyc R m
is: HMDB00139
initial concentration: 1.0
has only substance units: false
name: D-glycerate
constant: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: CHEBI:16659
is: SBO:0000247

metaR GLCURtly
name: glucuronate transport into lysososme
is described by: ECO:0000269
reactant: MODEL1310110052#
type: Reaction
modifier: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
is: SBO:0000185
product: MODEL1310110052#
reversible: true
kinetic law: MODEL1310110052#

metaM sql r
initial amount: NaN
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
has only substance units: false
type: Species
constant: false
is: HMDB00256
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15440
name: squalene
boundary condition: false

metaR EX lgnc LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lignoceric acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_dc390c59_a4ed_4494_b93f_227f7cf90eea
type: Species
constant: false
is: SBO:0000252
name: NDUFA10
boundary condition: true
is encoded by: hsa:4705
has only substance units: false
is: O95299
initial amount: NaN
initial concentration: NaN

metaR IDOAASE4ly
is version of: http://identifiers.org/ec-code/3.2.1.76
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110052#
is: SBO:0000176
fast: false
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
name: alpha-L-iduronidase, lysosomal

metaR ABUTD
name: Aminobutyraldehyde dehydrogenase
is described by: ECO:0000269
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
reversible: false
product: MODEL1310110052#
is: SBO:0000176
modifier: MODEL1310110052#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110052#_347114e3_811c_483d_a065_23cc47a6b901
name: ELOVL6
is: Q9H5J4
has only substance units: false
is encoded by: hsa:79071
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial amount: NaN

metaR COAtn
is: SBO:0000185
kinetic law: MODEL1310110052#
product: MODEL1310110052#
name: coenzyme A transport, nuclear
reversible: true
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
type: Reaction
is described by: ECO:0000000

metaR SACCD4m
modifier: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
reversible: false
kinetic law: MODEL1310110052#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.10 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
is version of: http://identifiers.org/ec-code/1.5.1.8
reactant: MODEL1310110052#
fast: false
name: saccharopine dehydrogenase (NAD, L-glutamate forming), mitochondrial
is: SBO:0000176

metaR PRDX
name: Peroxidase (multiple substrates)
is described by: ECO:0000000
kinetic law: MODEL1310110052#
is: SBO:0000176
type: Reaction
product: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (8288.1) SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:10464338 NOTES:RS/TV (6/3/05) Peroxidases can act on a variety of substrates which are oxidized, not just methanol.
modifier: MODEL1310110052#
reversible: false
is version of: http://identifiers.org/ec-code/1.11.1.7
reactant: MODEL1310110052#

metaM atp e
has only substance units: false
boundary condition: false
is: C00002
is: SBO:0000247
is: CHEBI:57299
type: Species
initial amount: NaN
is: HMDB00538
name: ATP(4-)
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_8e5af997_fdd6_4b2a_93a9_9fb752d398d6
type: Species
is encoded by: hsa:3613
has only substance units: false
name: IMPA2
boundary condition: true
initial amount: NaN
is: O14732
initial concentration: NaN
constant: false
is: SBO:0000252

metaM sgalside hs l
type: Species
has only substance units: false
name: sulfatide galactocerebroside
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00904
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
boundary condition: false
initial concentration: 1.0
is: CHEBI:16349

metaM CE5118 m
initial amount: NaN
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
has only substance units: false
is: SBO:0000247
is: CHEBI:57923
constant: false

metaM orot5p c
is: SBO:0000247
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: C01103
is: HMDB00218
name: Orotidine 5'-phosphate
is: CHEBI:57538
initial concentration: 1.0
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
has only substance units: false

metaR AKR1D
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
reactant: MODEL1310110052#
reversible: false
modifier: MODEL1310110052#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.3
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
kinetic law: MODEL1310110052#
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_971207a6_188b_4577_8f52_2220b3b251c0
name: H6PD
boundary condition: true
is: SBO:0000252
is: O95479
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9563

http://identifiers.org/biomodels.db/MODEL1310110052#_1f7f2b95_eb6d_46a0_837b_93e826292e31
has only substance units: false
name: ATP1A2
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: P50993
boundary condition: true
is: SBO:0000252
is encoded by: hsa:477

metaR r2347
name: Organic anion transporter 5 Utilized transport
reversible: true
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110052#_66ddaf00_76af_4b93_995c_6cd56a210c0b
initial amount: NaN
initial concentration: NaN
name: _AI222095_1_e
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:AI222095
type: Species

metaR HMGCOARc
kinetic law: MODEL1310110052#
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
is version of: http://identifiers.org/ec-code/1.1.1.34
is described by: ECO:0000134
fast: false
modifier: MODEL1310110052#
reactant: MODEL1310110052#
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol

http://identifiers.org/biomodels.db/MODEL1310110052#_d1b61dfc_a722_4949_b0d8_c5c12f198c92
is encoded by: hsa:AI191472
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: _AI191472_1_c
type: Species

metaM ksii core4 pre8 g
name: keratan sulfate II biosynthesis, precursor 8
type: Species
notes: FORMULA: C83H134N7O61SX CHARGE: -2
initial concentration: 1.0
is: C00130
is: CHEBI:58053
is: HMDB00175
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM dlnlcgcrn c
initial amount: NaN
name: dihomo-gamma-linolenyl carnitine
is: HMDB01311
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:16004

http://identifiers.org/biomodels.db/MODEL1310110052#_8c3893a1_4299_478e_a296_d81a16f60f0f
has only substance units: false
constant: false
is: SBO:0000252
name: LEFTY1
is encoded by: hsa:10637
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: O75610
type: Species

metaR r2133
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110052#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110052#

metaM adrncoa c
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205480
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
has only substance units: false
type: Species
name: adrenyl coenzyme A
is: SBO:0000247
is: C16170

http://identifiers.org/biomodels.db/MODEL1310110052#_446502ce_fe4f_4cfc_b875_1016fabe742a
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q53HE2
constant: false
initial concentration: NaN
is encoded by: hsa:7167
type: Species
name: TPI1

metaR r2136
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
reversible: false
is: SBO:0000185
product: MODEL1310110052#
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_ce1728b2_3172_441e_b085_7ce6e743371f
name: AGXT2
initial amount: NaN
is encoded by: hsa:64902
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is: Q9BYV1
type: Species

metaR NDP3ex
is version of: http://identifiers.org/ec-code/3.6.1.6
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
name: nucleoside-diphosphatase (GDP), extracellular
reversible: false
modifier: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
type: Reaction
fast: false

metaM gdp c
is: CHEBI:58189
constant: false
is: HMDB01201
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
name: GDP
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: C00035
initial amount: NaN

metaM gdpfuc c
name: GDP-L-fucose(2-)
initial amount: NaN
is: HMDB01095
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
is: CHEBI:57984

metaR HDCACBP
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM formcoa c
boundary condition: false
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
has only substance units: false
name: formyl-CoA(4-)
is: SBO:0000247
is: CHEBI:57376
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB03419

metaR COAtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110052#
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
reversible: true
name: coenzyme A transport, peroxisomal
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110052#_07974bd5_a09f_4bb4_854c_0f7e5b426676
initial amount: NaN
is encoded by: hsa:2745
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: GLRX
is: SBO:0000252
is: P35754
boundary condition: true

metaR GALASE1ly
kinetic law: MODEL1310110052#
reversible: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110052#
reactant: MODEL1310110052#
product: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction

metaM dgmp c
is: C00362
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
constant: false
type: Species
boundary condition: false
is: CHEBI:57673
has only substance units: false
initial amount: NaN
is: HMDB01044
name: dGMP
initial concentration: 1.0

metaR HOXG
reactant: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
is described by: ECO:0000134
name: Heme oxygenase 1
fast: false
reversible: false
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
is version of: http://identifiers.org/ec-code/1.14.99.3

metaR CHAT
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
fast: false
product: MODEL1310110052#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.6
name: Choline O-acetyltransferase
reactant: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#

metaR MI13PP
reversible: false
fast: false
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
name: inositol-1,3-bisphosphate 3-phosphatase
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176

metaM idour l
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: L-iduronate
is: HMDB02704
is: CHEBI:21338

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaR DECCRNe
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydecanoyl carnitine into extra cellular space
type: Reaction

metaM glyc c
initial amount: NaN
is: HMDB00131
name: Glycerol
is: SBO:0000247
type: Species
is: CHEBI:17754
constant: false
is: C00116
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR r0779
reversible: false
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
modifier: MODEL1310110052#
reactant: MODEL1310110052#
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
fast: false
kinetic law: MODEL1310110052#
is: SBO:0000176
type: Reaction

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR SEBCOACROT
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

metaR COAtr
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
kinetic law: MODEL1310110052#
reversible: true
is described by: ECO:0000000
name: COA transporter, endoplasmic reticulum
reactant: MODEL1310110052#
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_8f4b67b3_67b6_4e84_9aa2_6a60199a2131
initial concentration: NaN
type: Species
boundary condition: true
is: O95263
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8622
name: PDE8B

metaR S6T5g
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
product: MODEL1310110052#
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
kinetic law: MODEL1310110052#

metaR r2344
kinetic law: MODEL1310110052#
reversible: true
product: MODEL1310110052#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reactant: MODEL1310110052#
is: SBO:0000185

metaM ksi pre20 g
constant: false
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 20
is: CHEBI:28067
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_c80f238d_a3f4_46b9_93c3_096bab3d7dc5
type: Species
is encoded by: hsa:6510
name: SLC1A5
is: Q15758
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_6bdd6124_da94_4b7a_89a3_53ef550cf1d9
is: Q9BY07
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: SLC4A5
initial amount: NaN
boundary condition: true
is encoded by: hsa:57835
constant: false

metaR r2130
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_b4a33f97_95bc_42d5_bcab_8043748154b2
type: Species
is encoded by: hsa:157506
boundary condition: true
initial amount: NaN
name: RDH10
is: Q8IZV5
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_42dcfa5e_ecff_4d17_9959_dbd8a319eea5
type: Species
is encoded by: hsa:2686
initial amount: NaN
name: GGT7
boundary condition: true
is: A0PJJ9
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false

metaR S6T10g
type: Reaction
is described by: ECO:0000000
fast: false
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110052#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
reversible: false
reactant: MODEL1310110052#
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_3c99c3e8_5b07_4863_b27a_07417e8bfef9
name: ND1
is: SBO:0000252
is: Q85KV6
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4535
has only substance units: false
type: Species
initial amount: NaN
constant: false

metaR DOLP Lter
product: MODEL1310110052#
is: SBO:0000176
reversible: false
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
type: Reaction
name: dolichol phosphate flippase (liver)
kinetic law: MODEL1310110052#
is described by: ECO:0000000
fast: false

metaR PAFHe
is described by: ECO:0000269
kinetic law: MODEL1310110052#
reversible: false
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (7941.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:8675689 NOTES:NJ
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.47
reactant: MODEL1310110052#
is: SBO:0000176
name: Platelet-activating factor acetylhydrolase
fast: false
product: MODEL1310110052#

metaM hgentis c
has only substance units: false
name: homogentisate
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00130
is: CHEBI:16169
is: SBO:0000247
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
initial amount: NaN

metaM HC01231 m
initial concentration: 1.0
is: CHEBI:58480
initial amount: NaN
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
type: Species
boundary condition: false
name: N-[(R)-pantothenoyl]-L-cysteinate
has only substance units: false
constant: false
is: SBO:0000247

metaR FAOXC12DCx
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanedioyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_a8a94e31_7869_4d17_a70f_b1caf86cc785
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:205
initial concentration: NaN
type: Species
name: AK4
initial amount: NaN
constant: false

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

metaM abt e
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: HMDB01851
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: L-arabinitol
constant: false
is: CHEBI:18403
is: SBO:0000247

metaR DDCRNe
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydodecanoyl carnitine into extra cellular space
type: Reaction

metaM glc D e
is: CHEBI:4167
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: D-glucose
boundary condition: false
constant: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: HMDB00122

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

metaM hdd2crn m
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: HMDB06317
is: SBO:0000247
constant: false
name: trans-Hexadec-2-enoyl carnitine
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+

metaR r2079
product: MODEL1310110052#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110052#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_4ffb3fae_9d59_428f_8ee3_41c63a723f89
constant: false
is: O60909
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:8704
is: SBO:0000252
name: B4GALT2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_7f38798e_b2f7_434b_bde5_076d1b8e406f
type: Species
is: P31639
is: SBO:0000252
is encoded by: hsa:6524
constant: false
has only substance units: false
boundary condition: true
name: SLC5A2
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_e90ecde7_d207_4c2d_afdf_c5288b07b627
type: Species
is encoded by: hsa:26290
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is: Q9NY28
name: GALNT8
boundary condition: true

metaM xol27oh m
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB02103
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
type: Species
constant: false
name: 26-hydroxycholesterol
is: CHEBI:17703

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaR FAOXC5C5OHm
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C5OH)m
type: Reaction

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

metaR MG1er
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.106
type: Reaction
kinetic law: MODEL1310110052#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
modifier: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#

metaR r2346
reversible: true
kinetic law: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110052#
reactant: MODEL1310110052#
name: Organic anion transporter 5 Utilized transport
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110052#_fda0afed_a8eb_4574_a788_5485d3b6250e
name: PRPS1L1
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: P21108
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:221823

metaR r2132
reactant: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110052#
reversible: true
kinetic law: MODEL1310110052#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR NACHEXA14ly
reversible: false
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
kinetic law: MODEL1310110052#
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110052#
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR AG13T4g
product: MODEL1310110052#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110052#
type: Reaction
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.149

metaM gdpfuc g
is: CHEBI:57984
boundary condition: false
is: HMDB01095
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
name: GDP-L-fucose(2-)

metaM atp c
is: CHEBI:30616
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: C00002
name: ATP(4-)
initial amount: NaN
constant: false
is: HMDB00538
is: SBO:0000247

metaR THYMDt1
fast: false
product: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:9693094 NOTES:TDV
name: thymd transport
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110052#
reversible: false
modifier: MODEL1310110052#

metaM odecrn c
has only substance units: false
is: CHEBI:57394
constant: false
name: octadecenoyl carnitine
initial concentration: 1.0
is: C00412
boundary condition: false
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
is: HMDB01114
initial amount: NaN
type: Species

metaM acac x
is: SBO:0000247
type: Species
is: CHEBI:13705
boundary condition: false
name: acetoacetate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
constant: false
is: HMDB00060
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR r0149
product: MODEL1310110052#
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
reversible: true
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.39
is: SBO:0000176
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

metaM glc D c
is: HMDB00122
is: CHEBI:4167
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: D-glucose
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_99b158a0_7c00_4367_bad4_30c112c10ddd
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:AU149534
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: _AU149534_1_e

metaM abt c
is: CHEBI:18403
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
initial concentration: 1.0
is: HMDB01851
type: Species
name: L-arabinitol
initial amount: NaN

metaR G6PDH2rer
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
kinetic law: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.47
is described by: ECO:0000269
modifier: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
is: SBO:0000176

metaR HIVCACBP
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyisovalerylcoa from mitochondria into the cytosol
type: Reaction

metaR r2131
type: Reaction
reversible: true
reactant: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
product: MODEL1310110052#
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM CE5854 e
boundary condition: false
is: HMDB02710
initial amount: NaN
is: CHEBI:27485
has only substance units: false
name: gama-CEHC-glucuronide
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854

http://identifiers.org/biomodels.db/MODEL1310110052#_172b6fd0_e7bb_45ea_a513_2b5ae68c545e
initial amount: NaN
constant: false
type: Species
name: PFKL:PFKP
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5211
has only substance units: false
has part: Q7L2M7
is: SBO:0000297

metaR r2139
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110052#
product: MODEL1310110052#

metaR FAOXC12C12OHm
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->OHC12)m
type: Reaction

metaR LAPCOAl
fast: false
name: lysosomal acid phosphorylase (CoA)
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.2
product: MODEL1310110052#
reversible: false
reactant: MODEL1310110052#
is described by: ECO:0000304
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (53.1) SUBSYSTEM: CoA catabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:11923312,PMID:11994049 NOTES:IT. human enzymes overexpressed on E.coli, Pig Liver
kinetic law: MODEL1310110052#
is: SBO:0000176

metaM acgam c
constant: false
is: HMDB00215
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:17411
type: Species
boundary condition: false
name: N-acetyl-D-glucosamine
initial concentration: 1.0

metaM arachdcoa x
initial concentration: 1.0
is: CHEBI:57368
constant: false
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: arachidonoyl-CoA(4-)
is: HMDB06523

metaM 34dhpha c
is: SBO:0000247
initial amount: NaN
name: (3,4-dihydroxyphenyl)acetate
is: CHEBI:17612
boundary condition: false
constant: false
type: Species
has only substance units: false
is: HMDB01336
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
initial concentration: 1.0

metaR PHYTt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110052#
type: Reaction
name: fatty acid transport via diffusion
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
reversible: true

metaR PHCDm
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.5.1.12
reversible: false
type: Reaction
product: MODEL1310110052#
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is described by: ECO:0000304
reactant: MODEL1310110052#
is: SBO:0000176
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
fast: false

metaM HC02216 c
is: CHEBI:28922
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
name: prostaglandin-f2beta
constant: false
type: Species
has only substance units: false
initial amount: NaN

metaR DESAT18 4
reversible: false
fast: false
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
product: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
modifier: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.19.1
is described by: ECO:0000000

metaR BILDGLCURt
is: SBO:0000185
kinetic law: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
type: Reaction
product: MODEL1310110052#
reversible: true
modifier: MODEL1310110052#
reactant: MODEL1310110052#
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
is described by: ECO:0000269

metaR r1734
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
name: Y+LAT2 Utilized transport
reversible: false
is: SBO:0000185
modifier: MODEL1310110052#
is described by: ECO:0000000

metaM udp e
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:58223
type: Species
is: HMDB00295
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
constant: false
initial concentration: 1.0
name: UDP(3-)

http://identifiers.org/biomodels.db/MODEL1310110052#_31db0e42_1a2d_46ed_9b1e_56507e6f7859
constant: false
is: SBO:0000252
has only substance units: false
type: Species
is: P48201
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:518
boundary condition: true
name: ATP5G3

http://identifiers.org/biomodels.db/MODEL1310110052#_522fe48b_e7c5_4a77_b08c_127fc416d401
initial concentration: NaN
is: SBO:0000297
constant: false
is encoded by: hsa:4830
boundary condition: true
name: NME1:NME2
type: Species
has only substance units: false
initial amount: NaN

metaR r2361
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110052#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110052#
product: MODEL1310110052#

metaM ksii core2 pre5 g
is: SBO:0000247
is: CHEBI:58053
is: C00130
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 5
has only substance units: false
notes: FORMULA: C61H99N5O43X CHARGE: -1
initial concentration: 1.0

metaM fad x
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: CHEBI:16238
constant: false
is: SBO:0000247
type: Species
is: HMDB01248
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: Flavin adenine dinucleotide oxidized

metaR CEPTE
fast: false
modifier: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000176
name: ethanolamine phosphotransferase
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (10390.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.8.2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_3d040041_4973_4e32_b27c_bf1aa84906f6
is encoded by: hsa:6528
type: Species
name: SLC5A5
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q92911
constant: false
initial amount: NaN

metaR 5HLTDL
reversible: false
product: MODEL1310110052#
type: Reaction
name: 5-Hydroxy-L-tryptophan decarboxy-lyase
is version of: http://identifiers.org/ec-code/4.1.1.28
modifier: MODEL1310110052#
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:1540578 NOTES:SAB
is described by: ECO:0000269

metaR H2Oter
reactant: MODEL1310110052#
fast: false
name: H2O endoplasmic reticulum transport
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
type: Reaction
reversible: true

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_44bade99_bd62_48eb_bf0e_77c492263a39
initial amount: NaN
type: Species
is encoded by: hsa:39
initial concentration: NaN
is: SBO:0000252
is: Q9BWD1
has only substance units: false
constant: false
boundary condition: true
name: ACAT2

http://identifiers.org/biomodels.db/MODEL1310110052#_26c0e7b0_62e7_4956_ae70_e51d5fd74a58
boundary condition: true
has part: P48736
type: Species
has part: Q9UBK5
is encoded by: hsa:10870
is: SBO:0000297
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: HCST:PIK3CG
constant: false
is encoded by: hsa:5294

http://identifiers.org/biomodels.db/MODEL1310110052#_d860ce44_dcae_42d3_b94b_a8fa1436eae0
boundary condition: true
name: KHK
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: P50053
constant: false
initial amount: NaN
is encoded by: hsa:3795

metaR C142CPT1
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecadienoylcarnitine
type: Reaction

metaM 4hexdtricoa m
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: 4,7,10-hexadecatrienoylcoa
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: HMDB02288
is: SBO:0000247

metaR r0584
is described by: ECO:0000000
product: MODEL1310110052#
reactant: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
kinetic law: MODEL1310110052#
type: Reaction
fast: false

metaR HEX1
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.1.1
modifier: MODEL1310110052#
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.2
product: MODEL1310110052#
name: hexokinase (D-glucose:ATP)
is described by: ECO:0000134

metaR FACOAL160i
modifier: MODEL1310110052#
type: Reaction
fast: false
name: C160 fatty acid activation
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
product: MODEL1310110052#
reversible: false
is: SBO:0000176
reactant: MODEL1310110052#

metaR RE1807C
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
product: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#
name: RE1807

metaM ptdcacrn c
is: CHEBI:18303
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
is: SBO:0000247
name: pendtadenoyl carnitine
initial concentration: 1.0
constant: false

metaR r2362
is: SBO:0000185
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: true
type: Reaction
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_88ec1daf_73ed_4d3d_a397_290de52c660a
initial amount: NaN
constant: false
name: HSD3B1
is encoded by: hsa:3283
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is: P14060
boundary condition: true

metaR FAOXC15NADPx
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid alpha oxidation(2-Hydroxyphytanoyl-CoA)(nadp)x
type: Reaction

metaR r2137
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
reactant: MODEL1310110052#
product: MODEL1310110052#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110052#
reversible: true
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
modifier: MODEL1310110052#

metaM ksii core2 pre7 g
is: CHEBI:58053
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 7
notes: FORMULA: C67H108N5O51SX CHARGE: -2
is: C00130
is: HMDB00175

metaM ttdca e
is: HMDB00806
has only substance units: false
is: CHEBI:30807
initial concentration: 1.0
type: Species
is: C06424
constant: false
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
initial amount: NaN
name: tetradecanoate (n-C14:0)
boundary condition: false
is: SBO:0000247

metaR GLNtN1
type: Reaction
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is: SBO:0000185
name: Glutamine transport (Na, H coupled)
fast: false
reactant: MODEL1310110052#

metaR FAOXC12DCTc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dodecanedioyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_69339416_74c0_4d0b_b803_36c06cb98ba8
type: Species
constant: false
is: Q6NVY1
is encoded by: hsa:26275
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: HIBCH
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_e398f5c1_661c_466b_9ae2_90abcbdf1633
is encoded by: hsa:1109
is: P17516
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: AKR1C4
initial concentration: NaN

metaM udp c
constant: false
is: HMDB00295
initial concentration: 1.0
name: UDP
is: C00015
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:58223
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
boundary condition: false
has only substance units: false

metaM eicostetcrn c
constant: false
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:57312
name: Eicosatetranoyl carnitine
is: HMDB01356
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_69f2b1db_905e_421e_a807_c34cc18c0807
is: SBO:0000252
initial amount: NaN
name: CHST2
is encoded by: hsa:9435
is: Q9Y4C5
has only substance units: false
initial concentration: NaN
type: Species
constant: false
boundary condition: true

metaM 4abutn m
boundary condition: false
is: HMDB01080
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
constant: false
is: SBO:0000247
is: CHEBI:58264
name: 4-ammoniobutanal

metaR FAOXC7C5m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C7-->C5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_49eec8df_cc56_4b40_b447_afe23cccbbda
name: COX6B1
constant: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:1340
is: SBO:0000252
is: P14854
has only substance units: false

metaR r1090
kinetic law: MODEL1310110052#
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
reactant: MODEL1310110052#
fast: false
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaM ttdca c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:30807
name: myristate
constant: false
is: HMDB00806

metaM nac e
initial amount: NaN
initial concentration: 1.0
is: C00253
constant: false
boundary condition: false
is: HMDB01488
name: Nicotinate
type: Species
notes: FORMULA: C6H4NO2 CHARGE: -1
is: CHEBI:0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_fcbdd73e_1554_4006_8c4d_b7beb4a2e083
name: PAPSS2
initial amount: NaN
is encoded by: hsa:9060
has only substance units: false
is: O95340
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
constant: false

metaR ME1m
reversible: false
fast: false
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.1.38
product: MODEL1310110052#
name: malic enzyme (NAD), mitochondrial
is: SBO:0000176
reactant: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000

metaR r2360
is: SBO:0000185
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
type: Reaction
product: MODEL1310110052#
reversible: true
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000

metaR H2MTer L
reactant: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000000
name: H2 mannosyltransferase, endoplasmic reticulum
fast: false
modifier: MODEL1310110052#
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_d7a8dd9c_a485_4aab_a118_d5fb7350483f
is encoded by: hsa:3295
initial concentration: NaN
type: Species
name: HSD17B4
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: E9PB82
constant: false
has only substance units: false

metaR ASNtN1
name: Asparagine transport (Na, H coupled)
is: SBO:0000185
reactant: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269
fast: false
product: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction
reversible: true

metaR r2365
fast: false
type: Reaction
reactant: MODEL1310110052#
is: SBO:0000185
product: MODEL1310110052#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reversible: true

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaR GHMT2r
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.1
reactant: MODEL1310110052#
is described by: ECO:0000269
kinetic law: MODEL1310110052#
product: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
name: glycine hydroxymethyltransferase, reversible
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
reversible: true

metaR r0434
kinetic law: MODEL1310110052#
fast: false
modifier: MODEL1310110052#
product: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
is described by: ECO:0000000
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
type: Reaction
reactant: MODEL1310110052#
is: SBO:0000176

metaM decdp m
is: SBO:0000247
notes: FORMULA: C50H81O7P2 CHARGE: -3 INCHI: InChI=1/C50H90O7P2/c1-41(2)21-31-53-58(51,54-32-22-42(3)4)57-59(52,35-25-45(9)10,36-26-46(11)12,37-27-47(13)14,38-28-48(15)16,39-29-49(17)18,40-30-50(19)20,55-33-23-43(5)6)56-34-24-44(7)8/h21-30H,31-40H2,1-20H3
initial amount: NaN
name: all trans Decaprenyl diphosphate
is: HMDB06288
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_751df818_25f6_4a50_8a8e_bfd7413bf310
constant: false
boundary condition: true
has only substance units: false
name: COX7A2L
initial amount: NaN
is: Q6FGA0
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:9167
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_d034e6ca_1da9_4aeb_88ed_d5cff5065298
type: Species
initial amount: NaN
boundary condition: true
name: PGK1
constant: false
is: P00558
is encoded by: hsa:5230
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR DESAT18 8
fast: false
is described by: ECO:0000269
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
name: fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
reversible: false
modifier: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#

metaM apoC c
constant: false
is: CHEBI:33190
boundary condition: false
name: Apocarboxlase (no lys residue)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB11111
type: Species
has only substance units: false
notes: FORMULA: XH CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110052#_ba159350_7873_49e4_b94f_8ff43b8c0a1c
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:280
type: Species
constant: false
name: AMY2B
has only substance units: false
boundary condition: true
is: P19961

metaR r2366
type: Reaction
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110052#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110052#

metaR r0580
is version of: http://identifiers.org/ec-code/1.3.99.7
is described by: ECO:0000000
kinetic law: MODEL1310110052#
type: Reaction
reversible: true
is: SBO:0000176
fast: false
product: MODEL1310110052#
modifier: MODEL1310110052#
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:

metaR DPHMBDCm
fast: false
reactant: MODEL1310110052#
reversible: false
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate decarboxylation
type: Reaction
kinetic law: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212,PMID:7380842 NOTES:enzyme has not been identified yet IT
is: SBO:0000176
is described by: ECO:0000000

metaR 4ABUTtm
kinetic law: MODEL1310110052#
product: MODEL1310110052#
name: 4-aminobutanoate mitochondrial transport via diffusion
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD
reversible: true
reactant: MODEL1310110052#
is: SBO:0000185
type: Reaction

metaR ITPtn
kinetic law: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: ITP nuclear transport
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110052#_b27c38fb_2d62_40e8_a9c0_9e9ecc2da132
has only substance units: false
is encoded by: hsa:124935
boundary condition: true
initial concentration: NaN
type: Species
name: SLC43A2
constant: false
initial amount: NaN
is: Q8N370
is: SBO:0000252

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_35873300_916f_4882_830a_a546850b4a78
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P09960
has only substance units: false
type: Species
constant: false
name: LTA4H
is encoded by: hsa:4048

metaM HC01399 m
initial concentration: 1.0
type: Species
is: CHEBI:27466
initial amount: NaN
name: (S)-3-Hydroxytetradecanoyl-CoA
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
is: SBO:0000247

metaM h2o e
constant: false
is: SBO:0000247
type: Species
is: C00001
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
initial concentration: 1.0
is: CHEBI:15377
name: H2O
is: HMDB02111
initial amount: NaN
boundary condition: false

metaM ksi deg39 l
name: keratan sulfate I, degradation product 39
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C48H81N3O36 CHARGE: 0
is: HMDB00143
is: CHEBI:12936

metaR RE1520M
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110052#
name: RE1520
fast: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reversible: true

metaR AKR1C1
reversible: false
reactant: MODEL1310110052#
product: MODEL1310110052#
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (1645.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.1.20 Confidence Level: 4 AUTHORS: PMID:8486699 NOTES:NJ
is version of: http://identifiers.org/ec-code/1.3.1.20
type: Reaction
is described by: ECO:0000269
name: aldo-keto reductase family 1, member C1 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110052#_601582f6_4df0_4ddf_9433_f7fef6142d5c
has only substance units: false
initial concentration: NaN
type: Species
name: ACSL3
is encoded by: hsa:2181
constant: false
initial amount: NaN
is: O95573
is: SBO:0000252
boundary condition: true

metaR ENGASEly
reactant: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000176
name: endo-beta-N-acetylglucosaminidase, lysosomal
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110052#

metaM xoldioloneh c
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:2288
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
initial concentration: 1.0
is: HMDB06887
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_909ac599_3a84_44ae_a295_ac617871f562
type: Species
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AF080579
name: _AF080579_1_c

metaR ALASm
modifier: MODEL1310110052#
name: 5-aminolevulinate synthase
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.29
is version of: http://identifiers.org/ec-code/2.3.1.37
is described by: ECO:0000254
type: Reaction
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_377733a2_d72d_447f_abfe_a763962cd42e
boundary condition: true
constant: false
type: Species
name: COX6A1
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P12074
is encoded by: hsa:1337

metaM xol7a r
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
initial amount: NaN
boundary condition: false
name: 20-hydroxycholesterol
has only substance units: false
is: HMDB01496
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:1296
constant: false

metaR r2363
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110052#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110052#
fast: false
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110052#

metaM crn c
constant: false
is: C00318
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
type: Species
is: HMDB00062
is: SBO:0000247
boundary condition: false
name: L-Carnitine
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16347
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_86f7fa56_21bd_4270_9517_763138ea0a58
is encoded by: hsa:56301
has part: P08195
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:6520
has part: Q9NS82
boundary condition: true
constant: false
has only substance units: false
name: SLC7A10:SLC3A2
is: SBO:0000297

metaM HC02216 e
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
initial concentration: 1.0
is: CHEBI:28922
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: prostaglandin-f2beta
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_c7e309fc_fc7d_4123_bec5_55dbbc7140c1
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
name: _AI972237_1_c
is encoded by: hsa:AI972237
has only substance units: false

metaM ak2lgchol hs e
is: C04317
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6975
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
constant: false
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317

metaR HEX4
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.1
name: hexokinase (D-mannose:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.2
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
fast: false
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000176
product: MODEL1310110052#
modifier: MODEL1310110052#

metaR UMPK5n
is: SBO:0000176
reactant: MODEL1310110052#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
name: UMP kinase (dATP),nuclear
modifier: MODEL1310110052#
fast: false

metaM HC01434 m
has only substance units: false
constant: false
name: oxalatosuccinate(3-)
initial amount: NaN
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
is: CHEBI:58931
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_721c83f3_006a_4ba7_8334_23a07d0715a6
initial amount: NaN
has only substance units: false
is: Q02846
boundary condition: true
is encoded by: hsa:3000
is: SBO:0000252
initial concentration: NaN
name: GUCY2D
constant: false
type: Species

metaR FMNAT
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110052#
fast: false
is described by: ECO:0000134
reactant: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.7.2
name: FMN adenylyltransferase
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
type: Reaction

metaR G14T13g
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110052#
reversible: false
is: SBO:0000176
modifier: MODEL1310110052#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90

http://identifiers.org/biomodels.db/MODEL1310110052#_7300bcb9_0b45_4083_b94e_c866db1ab5f3
is: G5E960
name: PLCB3
type: Species
is encoded by: hsa:5331
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_47e5bf0d_7a85_4be7_8c02_650b66ea0fe1
constant: false
is: B4DU95
initial concentration: NaN
name: SOAT1
boundary condition: true
initial amount: NaN
is encoded by: hsa:6646
type: Species
is: SBO:0000252
has only substance units: false

metaR r2364
is: SBO:0000185
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: true
type: Reaction
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
fast: false

metaM mlthf c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
name: 5,10-Methylenetetrahydrofolate
initial amount: NaN
is: CHEBI:15636
is: HMDB01533
has only substance units: false
is: C00143
constant: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143

metaM ksi pre19 g
is: CHEBI:58053
is: HMDB00175
constant: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 19
type: Species
is: C00130
initial amount: NaN
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_99420a4f_0cf8_4eb1_8f46_e225b152cece
is: SBO:0000252
has only substance units: false
is: Q8NFW8
boundary condition: true
initial concentration: NaN
is encoded by: hsa:55907
initial amount: NaN
type: Species
name: CMAS
constant: false

metaR r1735
is: SBO:0000185
kinetic law: MODEL1310110052#
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
product: MODEL1310110052#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110052#
reactant: MODEL1310110052#

metaR 4HPRO LTte
product: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#
fast: false
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of trans-4-hydroxy-L-proline
kinetic law: MODEL1310110052#
is: SBO:0000185

metaM h2o g
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
initial concentration: 1.0
is: HMDB02111
has only substance units: false
initial amount: NaN
name: water
constant: false

metaR r0650
is: SBO:0000176
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is version of: http://identifiers.org/ec-code/4.1.1.36
reactant: MODEL1310110052#
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110052#
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_e57a366d_9634_444b_af93_55e56f826934
initial amount: NaN
name: NME7
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:29922
constant: false
boundary condition: true

metaR AG13T17g
type: Reaction
product: MODEL1310110052#
reversible: false
modifier: MODEL1310110052#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
kinetic law: MODEL1310110052#
is: SBO:0000176
is described by: ECO:0000000

metaR 4ABUTtcn
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: Jane D. Carver, W. Allan Walkera , The Journal of Nutritional Biochemistry, Volume 6, Issue 2, February 1995, Pages 58?72. NOTES:added during gap-filling, required for GABA role in cell proliferation.
is: SBO:0000185
reversible: false
reactant: MODEL1310110052#
is described by: ECO:0000134
name: transport of GABA
type: Reaction
kinetic law: MODEL1310110052#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_f2be9611_3447_48ba_b2f2_e968a187a2f4
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
name: DTYMK
is encoded by: hsa:1841
initial concentration: NaN
is: P23919
has only substance units: false
type: Species

metaM 4nph e
initial concentration: 1.0
initial amount: NaN
name: 4-nitrophenolate
type: Species
is: CHEBI:57917
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
boundary condition: false
is: HMDB01232

metaM eicostetcrn m
is: CHEBI:57312
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
type: Species
name: Eicosatetranoyl carnitine
initial amount: NaN
is: HMDB01356
has only substance units: false
constant: false

metaR RETNt
name: retinoic acid transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
fast: false
is: SBO:0000185
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110052#

metaR FACOAL200
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
name: fatty-acid--CoA ligase
reactant: MODEL1310110052#
modifier: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000269
is: SBO:0000176

metaM prostge2 e
is: HMDB01220
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:606564
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
name: prostaglandin E2(1-)
constant: false
boundary condition: false

metaR NTP3e
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
fast: false
is: SBO:0000176
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.6.1.6
is described by: ECO:0000269
reversible: false
product: MODEL1310110052#
type: Reaction
name: nucleoside-triphosphatase (GTP)
reactant: MODEL1310110052#

metaM dmantipyrine e
initial amount: NaN
is: HMDB06240
name: demethylated antipyrine
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C10H10N2O CHARGE: 0 INCHI: InChI=1/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-7,11H,1H3
has only substance units: false
constant: false
boundary condition: false

metaR 3DPHBH2
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212 NOTES:Used to make Ubiquinone-10 enzyme has not been identified yet. IT
type: Reaction
product: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#
name: Hydroxylation of 3-Decaprenyl-4-hydroxybenzoate (NADPH)
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110052#

metaM dcyt n
boundary condition: false
initial amount: NaN
is: HMDB00014
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
has only substance units: false
type: Species
is: SBO:0000247
name: 2'-deoxycytidine
constant: false
is: CHEBI:15698
initial concentration: 1.0

metaR r0651
reactant: MODEL1310110052#
is: SBO:0000176
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
fast: false
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
modifier: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
reversible: true

metaM udp n
is: SBO:0000247
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: CHEBI:58223
constant: false
name: UDP(3-)
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00295
initial amount: NaN

metaM pcrn x
boundary condition: false
is: http://identifiers.org/pubchem.compound/107738
type: Species
initial concentration: 1.0
is: HMDB00824
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
constant: false
is: SBO:0000247
has only substance units: false
name: propionyl-carnitine
initial amount: NaN

metaR RE3006M
reversible: true
name: RE3006
is: SBO:0000176
product: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110052#
type: Reaction

metaM urate e
boundary condition: false
is: C00366
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
has only substance units: false
is: HMDB00289
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:17775
name: Urate
initial concentration: 1.0

metaR FAOXC142C122m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_1b69c820_48be_47f2_91f9_98e765277c2e
has only substance units: false
is: B8ZZR8
constant: false
is: SBO:0000252
is encoded by: hsa:79017
initial amount: NaN
name: GGCT
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_233ad2f9_5252_4459_8528_5a5919c75874
is: O43306
initial concentration: NaN
type: Species
name: ADCY6
is encoded by: hsa:112
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_581d7aee_63e4_4dd4_8eeb_80522edfd40d
name: PANK4
is: SBO:0000252
is: Q9NVE7
type: Species
boundary condition: true
is encoded by: hsa:55229
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR TETPENT6t
product: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
reactant: MODEL1310110052#
reversible: true
type: Reaction
name: fatty acid transport via diffusion
fast: false
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_3b927020_3ccb_407f_9c95_350399cc31fa
constant: false
type: Species
name: NDUFA11
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:126328
initial concentration: NaN
boundary condition: true
is: C9JT23

metaR RE3568C
name: RE3568
type: Reaction
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000176
fast: false
reactant: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000

metaR r0652
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.2
fast: false
is: SBO:0000176
product: MODEL1310110052#

metaM uacgam c
has only substance units: false
constant: false
type: Species
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: HMDB00290
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57705
boundary condition: false

metaM 4nph c
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
initial concentration: 1.0
is: HMDB01232
is: CHEBI:57917
name: 4-nitrophenolate
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species

metaM prostge2 c
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
name: prostaglandin E2(1-)
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB01220
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:606564
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110052#_57eb7684_1ce2_401d_9984_c546e6a7b426
has only substance units: false
is encoded by: hsa:10195
name: ALG3
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species

metaR FACOAL203
reversible: true
is: SBO:0000176
reactant: MODEL1310110052#
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
name: fatty-acid--CoA ligase

http://identifiers.org/biomodels.db/MODEL1310110052#_baf68440_4cef_4342_b452_e3157957e9d3
boundary condition: true
constant: false
name: ALDH2
has only substance units: false
initial amount: NaN
is encoded by: hsa:217
is: SBO:0000252
is: P05091
type: Species
initial concentration: NaN

metaR VALLAT1tc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Valine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

metaM c226crn m
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
name: cervonyl carnitine
boundary condition: false
initial amount: NaN
is: HMDB06510
type: Species
is: http://identifiers.org/pubchem.compound/127055
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110052#_9d2b684d_14f3_4bf6_917c_6e67da2d8974
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: _X63359_1_c
boundary condition: true
constant: false
type: Species
is encoded by: hsa:X63359

metaM h2o c
is: SBO:0000247
initial concentration: 1.0
is: HMDB02111
is: C00001
constant: false
name: H2O
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:3303
has only substance units: false
notes: FORMULA: H2O CHARGE: 0

metaR HEX7
name: hexokinase (D-fructose:ATP)
product: MODEL1310110052#
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.1.2
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.1
kinetic law: MODEL1310110052#
is described by: ECO:0000304
is: SBO:0000176
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
reversible: false
modifier: MODEL1310110052#

metaR NAHCO3 HCLt
fast: false
is: SBO:0000185
product: MODEL1310110052#
modifier: MODEL1310110052#
reactant: MODEL1310110052#
reversible: true
is described by: ECO:0000269
name: bicarbonate transport (HCl/NaHCO3 exchange)
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
kinetic law: MODEL1310110052#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_a4c76247_b5ed_4b72_87d9_638a36b96a35
is: SBO:0000252
name: ADCY2
type: Species
initial amount: NaN
boundary condition: true
is: Q71UM8
constant: false
is encoded by: hsa:108
initial concentration: NaN
has only substance units: false

metaM udp l
is: HMDB00295
boundary condition: false
initial amount: NaN
is: CHEBI:58223
type: Species
initial concentration: 1.0
name: UDP(3-)
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015

metaM urate c
type: Species
is: HMDB00289
is: SBO:0000247
is: CHEBI:17775
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
initial concentration: 1.0
initial amount: NaN
name: Urate
is: C00366

metaR FAOXC61m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

metaR r0879
type: Reaction
reversible: false
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110052#_39baa304_9f22_41a3_9865_62ea7612b50c
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: TK2
type: Species
is: O00142
initial concentration: NaN
is encoded by: hsa:7084
constant: false
has only substance units: false

metaM dttp e
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: dTTP(4-)
type: Species
is: CHEBI:37568
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB01342

metaM but c
is: HMDB00039
type: Species
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
name: butyrate
is: CHEBI:17968
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_0df04da5_83d9_4218_8aca_311ea8dabfd5
boundary condition: true
name: HK1
is encoded by: hsa:3098
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P78542
constant: false
initial concentration: NaN
type: Species

metaR GUAPRT
kinetic law: MODEL1310110052#
name: guanine phosphoribosyltransferase
product: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.8
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110052#_562895c7_f06c_43bf_89a3_ce7a2349ec76
is: O75715
is encoded by: hsa:2880
boundary condition: true
initial amount: NaN
name: GPX5
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species

metaM glyc m
is: C00116
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:17754
is: HMDB00131
initial concentration: 1.0
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: SBO:0000247
name: Glycerol
type: Species

metaR r0587
type: Reaction
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110052#
is: SBO:0000176
product: MODEL1310110052#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110052#
fast: false
reactant: MODEL1310110052#

metaR ILETA
product: MODEL1310110052#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.42
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110052#
name: isoleucine transaminase
kinetic law: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_7bf36e7b_36f5_409a_b660_7623f1ccb016
has only substance units: false
name: BCKDHB
type: Species
initial amount: NaN
is: P21953
constant: false
is encoded by: hsa:594
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR DHORD9
is described by: ECO:0000269
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.3.5.2
name: dihydoorotic acid dehydrogenase (quinone10)
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
modifier: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#

metaM 3hddcoa c
is: HMDB00623
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: (S)-3-Hydroxydodecanoyl-CoA
type: Species
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
initial concentration: 1.0
constant: false
has only substance units: false

metaR CSNATr
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
name: carnitine O-acetyltransferase
kinetic law: MODEL1310110052#
reversible: true
is: SBO:0000176
product: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110052#_34607802_1fc3_4af2_a564_a9b6246124ef
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:728226
name: _728226_1_e

http://identifiers.org/biomodels.db/MODEL1310110052#_25d2a711_c9c2_47fb_b6e9_8343cd517258
initial amount: NaN
is: Q9Y2Q0
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
name: ATP8A1
is: SBO:0000252
constant: false
is encoded by: hsa:10396

http://identifiers.org/biomodels.db/MODEL1310110052#_3f1bdfff_fc0f_4fd9_9872_c0b93f3bf467
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q6LEN6
constant: false
is encoded by: hsa:1103
name: CHAT
is: SBO:0000252
has only substance units: false

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaR 2DR1PP
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
fast: false
reactant: MODEL1310110052#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110052#
product: MODEL1310110052#
name: 2-deoxy-D-ribose 1-phosphate phosphorylase

metaM glu L m
boundary condition: false
name: L-glutamate(1-)
is: HMDB00148
type: Species
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:29985

metaM HC02121 c
constant: false
is: CHEBI:58758
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
initial amount: NaN
has only substance units: false
name: S-(hydroxymethyl)glutathione(1-)
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR PHEt4
type: Reaction
kinetic law: MODEL1310110052#
reversible: false
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (54407.1) or (84889.1) or (11254.1) or (6542.1) or (81539.1) or (6541.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
modifier: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
name: L-phenylalanine transport in via sodium symport
product: MODEL1310110052#

metaM dttp c
initial concentration: 1.0
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: dTTP
boundary condition: false
is: C00459
constant: false
type: Species
is: CHEBI:37568
is: HMDB01342

http://identifiers.org/biomodels.db/MODEL1310110052#_4072bc93_2849_4d29_96b1_59daafd7f06e
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
name: PLA2G6
has only substance units: false
type: Species
is: A8K460
is encoded by: hsa:8398

metaM dmhptcrn e
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: 2,6 dimethylheptanoyl carnitine
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB06320
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_aac27f1f_0778_4159_96f8_7598abce64e9
is: Q96IJ6
boundary condition: true
initial concentration: NaN
is encoded by: hsa:29926
initial amount: NaN
constant: false
name: GMPPA
type: Species
is: SBO:0000252
has only substance units: false

metaR CORE3GTg
product: MODEL1310110052#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110052#
reactant: MODEL1310110052#
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
fast: false

metaR NADS2
is: SBO:0000176
kinetic law: MODEL1310110052#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110052#
modifier: MODEL1310110052#
name: NAD synthase (glutamine-hydrolysing)
type: Reaction
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/6.3.5.1
fast: false
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR CSNATp
reactant: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
product: MODEL1310110052#
reversible: true
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.7
is: SBO:0000176
type: Reaction
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
modifier: MODEL1310110052#

metaR GALASE11ly
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
modifier: MODEL1310110052#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23

metaM nac c
is: CHEBI:0
constant: false
name: Nicotinate
is: SBO:0000247
is: C00253
type: Species
notes: FORMULA: C6H4NO2 CHARGE: -1
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB01488
initial concentration: 1.0

metaR FAOXTC122m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization trans(C12:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_fca5a73b_0976_4ded_9c11_2c1addefd777
type: Species
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:80724
is: G3XAJ0
boundary condition: true
is: SBO:0000252
name: ACAD10
initial concentration: NaN

metaM ala L e
is: SBO:0000247
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: HMDB00161
type: Species
initial amount: NaN
name: L-alanine
is: CHEBI:16977
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR EX 3ddcrn
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

metaR RE2649C
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
name: RE2649
is version of: http://identifiers.org/ec-code/3.1.2.2
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176

metaR PGMT
name: phosphoglucomutase
reversible: true
modifier: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.2.2
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134

metaM arachdcoa m
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: CHEBI:57368
is: HMDB06523
name: arachidonoyl-CoA(4-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_42ccc242_3f2d_4a7b_9a0d_dbf0137025f5
type: Species
is: SBO:0000252
is encoded by: hsa:2982
name: GUCY1A3
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: D6RDW3

http://identifiers.org/biomodels.db/MODEL1310110052#_d61ccbbc_aa4b_48b8_b3b2_ab36f1ce6a3e
is: Q308M7
has only substance units: false
constant: false
type: Species
is encoded by: hsa:5169
name: ENPP3
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM udp g
constant: false
name: UDP(3-)
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: CHEBI:58223
is: HMDB00295
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR MALtm
name: malate transport, mitochondrial
is: SBO:0000185
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000269
fast: false
type: Reaction
reversible: true
product: MODEL1310110052#

metaR GLYCt
is: SBO:0000185
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
name: glycerol transport via channel
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
product: MODEL1310110052#
type: Reaction
reversible: true

metaR DLNLCGCRNt
is described by: ECO:0000000
is: SBO:0000185
name: transport into the mitochondria (carnitine)
fast: false
reversible: false
kinetic law: MODEL1310110052#
type: Reaction
modifier: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110052#_5be7c683_f89d_4f37_8bdd_e3f59d6c2676
name: NDUFC2
constant: false
has only substance units: false
is encoded by: hsa:4718
initial concentration: NaN
boundary condition: true
type: Species
is: Q549M5
initial amount: NaN
is: SBO:0000252

metaM ksi pre34 g
boundary condition: false
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
is: SBO:0000247
constant: false
type: Species
name: keratan sulfate I biosynthesis, precursor 34
is: CHEBI:58053
has only substance units: false
initial concentration: 1.0
is: C00130
initial amount: NaN
is: HMDB00175

metaR GLCNACPT L
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110052#
reversible: false
type: Reaction
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.8.15
kinetic law: MODEL1310110052#
is: SBO:0000176
is described by: ECO:0000000
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (liver)
fast: false
product: MODEL1310110052#

metaR LEUTA
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
is version of: http://identifiers.org/ec-code/2.6.1.42
reversible: true
reactant: MODEL1310110052#
is described by: ECO:0000269
name: leucine transaminase
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is: SBO:0000176
type: Reaction
product: MODEL1310110052#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_2d6de4aa_742e_4e37_a394_ed7ecd8e205a
is: Q4FEB3
name: CMA1
boundary condition: true
type: Species
is encoded by: hsa:1215
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR RE1836X
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110052#
name: RE1836
fast: false
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.176

metaM hyptaur c
is: SBO:0000247
is: HMDB00965
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
constant: false
is: CHEBI:16668
type: Species
name: Hypotaurine
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN

metaR RE2626M
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000000
reactant: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000176
modifier: MODEL1310110052#
name: RE2626
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:

metaM dmhptcrn c
has only substance units: false
name: 2,6 dimethylheptanoyl carnitine
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
is: HMDB06320
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_525ca8c8_1a2f_4833_8d0e_8de22960b639
is: SBO:0000252
is: Q99807
boundary condition: true
initial amount: NaN
name: COQ7
is encoded by: hsa:10229
has only substance units: false
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_81a1f507_3890_4e73_9fb7_e25a9ea68cfe
initial concentration: NaN
is: SBO:0000252
name: CHST3
is: Q7LGC8
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:9469

metaR FUCtly
product: MODEL1310110052#
type: Reaction
reversible: false
kinetic law: MODEL1310110052#
name: L-fucose efflux from lysosome
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
reactant: MODEL1310110052#

metaR RE1807M
modifier: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reactant: MODEL1310110052#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110052#
name: RE1807
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110052#_0890743c_7e40_4d84_8e67_4b37e6732de0
initial amount: NaN
type: Species
is: SBO:0000252
name: ENTPD1
has only substance units: false
constant: false
boundary condition: true
is: Q86VV3
is encoded by: hsa:953
initial concentration: NaN

metaM ala L c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
constant: false
is: HMDB00161
type: Species
name: L-alanine
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:16977

metaR C3STDH1Pr
reactant: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.170
type: Reaction
is described by: ECO:0000134
name: C-3 sterol dehydrogenase (4-methylzymosterol)
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
modifier: MODEL1310110052#

metaR FAOXC143C123m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

metaR r0009
modifier: MODEL1310110052#
is: SBO:0000176
reversible: false
product: MODEL1310110052#
fast: false
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
reactant: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.1
is described by: ECO:0000000
kinetic law: MODEL1310110052#

metaM ddcacoa m
is: C01832
initial amount: NaN
constant: false
is: HMDB03571
initial concentration: 1.0
name: Dodecanoyl-CoA (n-C12:0CoA)
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: CHEBI:57375
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR PEAMNO
is version of: http://identifiers.org/ec-code/1.4.3.22
is version of: http://identifiers.org/ec-code/1.4.3.4
is described by: ECO:0000304
type: Reaction
fast: false
reactant: MODEL1310110052#
reversible: false
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.4.3.21
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
product: MODEL1310110052#
name: Phenethylamine oxidase
modifier: MODEL1310110052#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110052#_62908a0e_01da_4aed_b0a5_60004d9eeaf2
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:AA614647
name: _AA614647_1_c
initial concentration: NaN
has only substance units: false

metaM pail4p hs c
constant: false
has only substance units: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
initial concentration: 1.0
boundary condition: false
is: CHEBI:58178
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_ea5bb5d8_602c_41c7_aabb_ab7085dcab75
has only substance units: false
boundary condition: true
is: Q9Y666
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10723
name: SLC12A7
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_75a1c117_3365_4d98_8ba2_a655e994d45e
initial concentration: NaN
type: Species
name: PYCRL
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:65263
has only substance units: false
is: Q53H96

http://identifiers.org/biomodels.db/MODEL1310110052#_81905001_039b_4a36_a5c1_d6edc27fe5cb
has only substance units: false
name: B3GNT2
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10678
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_557cdeed_0646_4913_82e6_8aa8ef16c989
is: Q9NWU1
has only substance units: false
constant: false
type: Species
is encoded by: hsa:54995
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: OXSM
initial concentration: NaN

metaM k c
name: potassium
is: HMDB00586
has only substance units: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: C00238
constant: false
boundary condition: false
type: Species
is: CHEBI:29103
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaR PVD3
type: Reaction
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
is: SBO:0000176
kinetic law: MODEL1310110052#
name: Previtamin D3 formation
reactant: MODEL1310110052#
product: MODEL1310110052#
fast: false

metaM dcsptn1 c
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB13123
boundary condition: false
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
is: http://identifiers.org/pubchem.compound/5282848
name: docosa-4,7,10,13,16-pentaenoic acid
is: SBO:0000247
type: Species

metaM 10fthf7glu e
initial concentration: 1.0
type: Species
is: HMDB00108
constant: false
is: CHEBI:16236
notes: FORMULA: C50H57N13O25 CHARGE: -8
has only substance units: false
name: 10-formyltetrahydrofolate-[Glu](7)
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR MANtly
is: SBO:0000185
reactant: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
fast: false
reversible: false
name: mannose efflux from lysosome
is described by: ECO:0000000
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_9de13dda_3d37_4884_bfac_03012be20c54
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
name: DGKZ
is encoded by: hsa:8525
initial amount: NaN
is: B7Z2M9
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_9058189a_9b74_4cb4_ab85_c876521aee4a
is encoded by: hsa:U52111
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: _U52111_1_c

metaM asn L c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
name: L-asparagine
type: Species
is: HMDB00168
is: CHEBI:17196
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false

metaR LCADi D
reversible: false
modifier: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.36
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
fast: false
is described by: ECO:0000304
name: lactaldehyde dehydrogenase

http://identifiers.org/biomodels.db/MODEL1310110052#_0903d333_8c40_4048_bc56_1434b1c8a29e
initial amount: NaN
name: PDE8A
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is: H0YMZ7
is encoded by: hsa:5151

metaM dhcholestanate x
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: HMDB00359
is: CHEBI:16577
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate

metaR EX adrn LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adrenic acid exchange
type: Reaction

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

metaM acetone e
has only substance units: false
name: acetone
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
type: Species
is: CHEBI:15347
initial amount: NaN
boundary condition: false
is: HMDB01659

metaM HC02213 e
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:28031
constant: false
name: prostaglandin-e3
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110052#_bd2cfd4c_ee64_4436_bfe6_6309e8889e6d
boundary condition: true
constant: false
is: P51160
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:5146
initial amount: NaN
name: PDE6C
initial concentration: NaN

metaM xol7ah c
boundary condition: false
name: 7alpha-hydroxy-5beta-cholestan-3-one
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
is: HMDB06892
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:2290
type: Species
initial concentration: 1.0
has only substance units: false

metaM HC00695 m
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
name: S-Succinyldihydrolipoamide
type: Species
is: CHEBI:17432
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
is: SBO:0000247

metaM maltpt e
is: http://identifiers.org/pubchem.compound/5141
is: C02052
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
boundary condition: false
initial amount: NaN
has only substance units: false
name: maltopentaose
is: SBO:0000247
is: HMDB01296
initial concentration: 1.0
constant: false
type: Species

metaR C140CPT1
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of myristoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_0c57bbf7_6453_4a87_934e_ae018604636f
constant: false
name: ALDH1A2
is: SBO:0000252
initial amount: NaN
type: Species
is: O94788
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8854

metaR FAOXC163GC142m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaM c226crn c
is: SBO:0000247
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
has only substance units: false
name: cervonyl carnitine
boundary condition: false
is: http://identifiers.org/pubchem.compound/127055
initial amount: NaN
constant: false
is: HMDB06510
type: Species
initial concentration: 1.0

metaR GLYBt4 2 r
type: Reaction
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000269
reactant: MODEL1310110052#
reversible: true
is: SBO:0000185
fast: false
name: Betaine transport (sodium symport) (2:1)
notes: GENE_ASSOCIATION: (6539.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

metaR CSNATm
kinetic law: MODEL1310110052#
name: carnitine O-aceyltransferase, mitochondrial
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.7
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
reversible: true
reactant: MODEL1310110052#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110052#
fast: false

metaM peamn c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB12275
type: Species
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
name: 2-phenylethanaminium
is: CHEBI:225237
constant: false
is: SBO:0000247
boundary condition: false

metaR S6T8g
reactant: MODEL1310110052#
product: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110052#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_d2455f56_364f_48e7_80ac_240a0f31f931
name: UCKL1
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q53HM1
is encoded by: hsa:54963

http://identifiers.org/biomodels.db/MODEL1310110052#_525353a3_a771_4ef7_b4ab_7e3721ca3fca
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: Q9Y673
is encoded by: hsa:29880
name: ALG5

metaR LGNCCOAtx
product: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
is described by: ECO:0000000
name: fatty acid intracellular transport
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaR C3STDH1r
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110052#
name: C-3 sterol dehydrogenase (4-methylzymosterol)
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.170
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ
fast: false
reversible: false
modifier: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_9659f8ea_0264_4377_99f6_b2ff16a56b3e
is: B2R6S5
constant: false
boundary condition: true
is encoded by: hsa:51727
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
name: CMPK1
has only substance units: false

metaM dttp n
name: dTTP
is: C00459
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: CHEBI:37568
type: Species
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB01342
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_51364b0f_2b09_43e4_89c3_7260b6418a1c
name: VNN2
is encoded by: hsa:8875
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: O95498
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_284425d3_3dbf_44ce_97a8_5e3eb62157e0
initial concentration: NaN
initial amount: NaN
name: ENTPD4
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9583
is: Q9Y227
has only substance units: false

metaR RAI2
is described by: ECO:0000000
name: retinal isomerase (9-cis)
kinetic law: MODEL1310110052#
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reversible: true

metaM k e
is: HMDB00586
name: potassium
is: C00238
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: SBO:0000247
type: Species
is: CHEBI:29103
initial amount: NaN
initial concentration: 1.0

metaM ksi deg41 l
boundary condition: false
is: CHEBI:12936
is: HMDB00143
is: SBO:0000247
name: keratan sulfate I, degradation product 41
constant: false
initial amount: NaN
notes: FORMULA: C34H58N2O26 CHARGE: 0
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_b935e847_9c0d_4185_9607_95ed66d0a211
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: _N63787_1_c
is encoded by: hsa:N63787
type: Species
boundary condition: true

metaR r0871
kinetic law: MODEL1310110052#
name: Diffusion
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409 NOTES:
is: SBO:0000185
product: MODEL1310110052#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000

metaM HC01434 x
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
is: CHEBI:58931
type: Species
is: SBO:0000247
boundary condition: false
name: oxalatosuccinate(3-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_055d6903_09dd_4750_984b_db692a39ca63
is encoded by: hsa:23057
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: NMNAT2
is: Q9BZQ4

http://identifiers.org/biomodels.db/MODEL1310110052#_e3052e08_d5c9_4acb_a92d_553500b6f4b0
boundary condition: true
is encoded by: hsa:LOC647190
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
name: _LOC647190_1_c

metaR ALDD2x
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.2.1.36
is described by: ECO:0000000
name: aldehyde dehydrogenase (acetaldehyde, NAD)
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110052#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110052#
type: Reaction
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
modifier: MODEL1310110052#

metaR GLXtp
reversible: true
kinetic law: MODEL1310110052#
fast: false
is: SBO:0000185
product: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
reactant: MODEL1310110052#
name: glyoxylate transport, peroxisomal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_e96ed067_15ff_4e26_8e46_9d98f1aa481b
is encoded by: hsa:51022
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
name: GLRX2
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_3d3fc492_0e76_4c69_a369_d070564ac3bb
boundary condition: true
name: SLC26A6
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is: Q9Y3Y1
constant: false
initial concentration: NaN
is encoded by: hsa:65010

http://identifiers.org/biomodels.db/MODEL1310110052#_6597df4a_1fce_4045_8ccf_5c9a1cc4d468
is encoded by: hsa:6898
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: TAT
has only substance units: false
initial amount: NaN
is: P17735
constant: false

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR SUCCt4 2
name: succinate transport via sodium symport
modifier: MODEL1310110052#
is: SBO:0000185
kinetic law: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110052#
type: Reaction
product: MODEL1310110052#

metaM asn L e
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
name: L-asparagine
constant: false
initial concentration: 1.0
is: CHEBI:17196
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: HMDB00168
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_dda73d38_ebe5_4171_9358_00d6f8b9c499
is: SBO:0000252
has only substance units: false
is: Q76EJ3
is encoded by: hsa:11046
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
name: SLC35D2
constant: false

metaR r1958
is: SBO:0000185
is described by: ECO:0000000
reversible: false
type: Reaction
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reactant: MODEL1310110052#
fast: false
product: MODEL1310110052#
kinetic law: MODEL1310110052#

metaR r0870
fast: false
is version of: http://identifiers.org/ec-code/3.6.4.13
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.7.72
reversible: true
reactant: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.1
is: SBO:0000185
product: MODEL1310110052#
is described by: ECO:0000000
modifier: MODEL1310110052#
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.1.3.4

metaM 4h2oglt m
type: Species
is: SBO:0000247
initial amount: NaN
name: 4-hydroxy-2-oxoglutarate(2-)
boundary condition: false
constant: false
is: CHEBI:17742
initial concentration: 1.0
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
is: HMDB02070
has only substance units: false

metaM HC02213 c
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: prostaglandin-e3
is: CHEBI:28031
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439

http://identifiers.org/biomodels.db/MODEL1310110052#_c6197eaa_2f75_4f38_8083_553104019c73
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaM HC02175 e
constant: false
initial concentration: 1.0
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
name: caprate
is: SBO:0000247
is: CHEBI:27689
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_3290f6c8_e9a3_4138_9304_21307ac291b3
initial concentration: NaN
type: Species
is: Q9Y5L3
name: ENTPD2
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:954
is: SBO:0000252

metaM C02528 c
is: CHEBI:36234
is: SBO:0000247
name: chenodeoxycholate
initial concentration: 1.0
is: HMDB00518
initial amount: NaN
has only substance units: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_f489b20b_989d_47f5_a05f_2f92c99b2105
boundary condition: true
initial amount: NaN
constant: false
is: Q9GZX3
type: Species
initial concentration: NaN
name: CHST6
is encoded by: hsa:4166
is: SBO:0000252
has only substance units: false

metaR THRGLNexR
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
type: Reaction
product: MODEL1310110052#
name: L-threonine/glycine reversible exchange
is described by: ECO:0000304
modifier: MODEL1310110052#
reversible: true
kinetic law: MODEL1310110052#
is: SBO:0000185

metaR ALDD2y
kinetic law: MODEL1310110052#
name: aldehyde dehydrogenase (acetaldehyde, NADP)
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
fast: false
product: MODEL1310110052#
reactant: MODEL1310110052#
modifier: MODEL1310110052#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.36
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM 4abutn c
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58264
name: 4-Aminobutanal
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: HMDB01080
is: C00555
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_aeb4a4d7_1066_4a29_8e3c_1c146829ae37
is: P16219
has only substance units: false
initial amount: NaN
name: ACADS
initial concentration: NaN
is encoded by: hsa:35
type: Species
constant: false
boundary condition: true
is: SBO:0000252

metaM lnlncgcoa c
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
name: gamma-linolenoyl-CoA(4-)
constant: false
has only substance units: false
is: CHEBI:57363
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB06368
boundary condition: false

metaR PCRNtm
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
name: transport into the mitochondria from cytosol (carnitine)
is: SBO:0000185
product: MODEL1310110052#
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
is described by: ECO:0000000

metaM ala L m
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16977
has only substance units: false
is: HMDB00161
name: L-alanine
constant: false

metaR FACOAL204
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
product: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
name: fatty-acid--CoA ligase
is described by: ECO:0000269
reversible: true
is: SBO:0000176
modifier: MODEL1310110052#

metaR r2140
kinetic law: MODEL1310110052#
fast: false
is: SBO:0000185
modifier: MODEL1310110052#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110052#_95a92c8f_9d7c_4487_9e1e_e69423eb0e78
is: P47989
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:7498
name: XDH
has only substance units: false
type: Species

metaM leuktrB4 e
name: leukotriene B4(1-)
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57461
has only substance units: false
is: HMDB01085

metaR CDIPTr
fast: false
type: Reaction
name: phosphatidylinositol synthase (Homo sapiens)
modifier: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.8.11
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD

metaR r0655
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000176
product: MODEL1310110052#
modifier: MODEL1310110052#
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
is described by: ECO:0000000
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
fast: false
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110052#_0a786475_bb4a_4fa7_a595_156a4034da30
type: Species
is: O43181
has only substance units: false
boundary condition: true
is encoded by: hsa:4724
name: NDUFS4
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN

metaR GMPtg
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
reversible: true
name: GMP transport (Golgi)
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
type: Reaction
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_21d80578_50cc_4ed3_aecb_aefa920cbb31
boundary condition: true
name: SCP2
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is: C9JC79
is encoded by: hsa:6342
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_3d106286_4679_4aaa_ad35_851980df142d
boundary condition: true
initial concentration: NaN
is: Q969K7
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:113452
name: TMEM54
type: Species
constant: false

metaM ksi pre17 g
name: keratan sulfate I biosynthesis, precursor 17
has only substance units: false
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
is: CHEBI:28067

metaM dmhptcrn m
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
type: Species
boundary condition: false
is: HMDB06320
initial amount: NaN
has only substance units: false
name: 2,6 dimethylheptanoyl carnitine

metaM meoh e
name: methanol
is: HMDB01875
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:17790

metaM thymd m
initial amount: NaN
initial concentration: 1.0
constant: false
is: C00214
is: HMDB00273
is: CHEBI:17748
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
name: Thymidine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_22cbfb8a_ea9c_4ed4_b667_d22a37a160b7
is encoded by: hsa:113026
constant: false
name: PLCD3
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is: Q8N3E9

metaR PROSTGE1t
modifier: MODEL1310110052#
is described by: ECO:0000269
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
product: MODEL1310110052#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110052#_88e55394_6f10_46a8_9ba4_cb74d71b479c
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q6NZ59
is encoded by: hsa:522
has only substance units: false
initial amount: NaN
constant: false
name: ATP5J

metaM HC02175 c
boundary condition: false
is: SBO:0000247
name: caprate
has only substance units: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:27689

metaM e4hglu m
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:6331
initial concentration: 1.0
name: erythro-4-hydroxy-L-glutamate(1-)
is: HMDB02273
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
boundary condition: false
initial amount: NaN
type: Species

metaR FACOAL205
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true
is: SBO:0000176
product: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110052#_ae5ec464_5aad_4121_a96e_11036f903687
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: AMY1A
boundary condition: true
type: Species
is: Q6NSB3
is encoded by: hsa:276
constant: false

metaR VLCS2r
reversible: false
is described by: ECO:0000304
modifier: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
is: SBO:0000176
name: Very-long-chain-fatty-acid-CoA ligase
fast: false

metaR ADKd
reversible: true
product: MODEL1310110052#
modifier: MODEL1310110052#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
name: adenylate kinase (d form)
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110052#_07796c7e_132b_491a_a10f_ad79748743f1
is: SBO:0000252
is encoded by: hsa:2983
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: Q02153
name: GUCY1B3
has only substance units: false

metaM 2dpmhobq m
name: 2-decaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C58H88O4 CHARGE: 0 INCHI: InChI=1S/C58H88O4/c1-43(2)23-14-24-44(3)25-15-26-45(4)27-16-28-46(5)29-17-30-47(6)31-18-32-48(7)33-19-34-49(8)35-20-36-50(9)37-21-38-51(10)39-22-40-52(11)41-42-54-53(12)55(59)57(61)58(62-13)56(54)60/h23,25,27,29,31,33,35,37,39,41,61H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b44-25+,45-27+,46-29+,47-31+,48-33+,49-35+,50-37+,51-39+,52-41+
initial amount: NaN
constant: false
is: HMDB06484
is: CHEBI:50771
is: SBO:0000247
boundary condition: false

metaR RE1342C
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
fast: false
reactant: MODEL1310110052#
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110052#
is: SBO:0000176
name: RE1342

metaR CYANt
is described by: ECO:0000000
product: MODEL1310110052#
fast: false
reversible: true
reactant: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
is: SBO:0000185
kinetic law: MODEL1310110052#
name: Cyanide transport via diffusion (extracellular to cytosol)

http://identifiers.org/biomodels.db/MODEL1310110052#_20d11649_86ba_4243_939e_734949ed9ed0
is: SBO:0000297
boundary condition: true
is encoded by: hsa:4830
name: NME1:NME2
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaR FACOAL206
name: fatty-acid--CoA ligase
type: Reaction
reactant: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110052#
is: SBO:0000176
modifier: MODEL1310110052#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_2e8d67cc_88b0_4593_8fec_bf6010403da5
is: SBO:0000252
type: Species
boundary condition: true
is: P31040
constant: false
is encoded by: hsa:6389
has only substance units: false
initial amount: NaN
name: SDHA
initial concentration: NaN

metaR HDECAACBP
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecanoylcoa from mitochondria into the cytosol
type: Reaction

metaM leuktrB4 c
boundary condition: false
is: HMDB01085
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
is: CHEBI:57461
has only substance units: false
name: leukotriene B4(1-)

metaR MALSO3tm
modifier: MODEL1310110052#
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
is described by: ECO:0000269
fast: false
name: Malate:sulfite antiport, mitochondrial
kinetic law: MODEL1310110052#

metaM tsul m
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
boundary condition: false
is: HMDB00257
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: CHEBI:16094
initial concentration: 1.0
has only substance units: false
name: thiosulfate(2-)

metaR ABTD
is described by: ECO:0000000
reactant: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110052#
reversible: true
fast: false
name: L-arabinitol 4-dehydrogenase

metaM 4hbz m
has only substance units: false
name: 4-hydroxybenzoate
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00500
is: CHEBI:17879
notes: FORMULA: C7H5O3 CHARGE: -1 INCHI: InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)/p-1
type: Species
initial concentration: 1.0
initial amount: NaN

metaM dhcholestanate r
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16577
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: SBO:0000247
is: HMDB00359
constant: false
type: Species
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
has only substance units: false

metaR P45027A11m
is: SBO:0000176
modifier: MODEL1310110052#
reactant: MODEL1310110052#
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
fast: false
reversible: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
type: Reaction
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000269

metaM ethamp c
is: HMDB00224
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58190
name: ethamp[c]
has only substance units: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
boundary condition: false
constant: false

metaR PIACGT
is version of: http://identifiers.org/ec-code/2.4.1.198
type: Reaction
fast: false
modifier: MODEL1310110052#
is: SBO:0000176
product: MODEL1310110052#
name: phosphatidylinositol N-acetylglucosaminyltransferase
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.83

metaR GLCAASE9ly
product: MODEL1310110052#
reactant: MODEL1310110052#
reversible: false
is: SBO:0000176
name: beta-glucuronidase, lysosomal
type: Reaction
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
modifier: MODEL1310110052#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.31

http://identifiers.org/biomodels.db/MODEL1310110052#_ae324ab0_7d6e_4d95_b595_85b984da31b9
initial concentration: NaN
is encoded by: hsa:518
has only substance units: false
is: SBO:0000252
constant: false
name: ATP5G3
boundary condition: true
initial amount: NaN
type: Species

metaR RE0691C
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
name: RE0691
kinetic law: MODEL1310110052#
fast: false
product: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#
type: Reaction

metaR VLCS2p
modifier: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110052#
name: Very-long-chain-fatty-acid-CoA ligase
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: PMID:10479480 NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
reversible: false

metaR GLXtm
name: glyoxylate transport, mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_f8dc0d81_3eae_4876_bed0_908084f82af9
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:124
boundary condition: true
has only substance units: false
has part: P07327
name: ADH1A:ADH1B
constant: false
type: Species
initial concentration: NaN

metaR TIGCRNe
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tiglyl carnitine into the extra cellular fluid
type: Reaction

metaM acetone c
constant: false
initial concentration: 1.0
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
has only substance units: false
type: Species
is: HMDB01659
is: CHEBI:15347
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: acetone

metaR RE2349C
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
kinetic law: MODEL1310110052#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.64
product: MODEL1310110052#
is described by: ECO:0000000
modifier: MODEL1310110052#
is: SBO:0000176
name: RE2349
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_f9fafc4b_3a34_4389_af6a_39bbc95dcda2
constant: false
is: O15056
has only substance units: false
name: SYNJ2
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8871
initial amount: NaN
boundary condition: true

metaR SACCD3m
modifier: MODEL1310110052#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reversible: false
product: MODEL1310110052#
name: saccharopine dehydrogenase (NADP, L-lysine forming), mitochondrial
is version of: http://identifiers.org/ec-code/1.5.1.8
fast: false
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.8 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_686bfe1c_bb19_4e61_bcef_f5880ed2a74e
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is: P30049
is encoded by: hsa:513
name: ATP5D
initial amount: NaN
constant: false
boundary condition: true

metaR HAS2
type: Reaction
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000185
reversible: false
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.212
reactant: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
name: hyaluronan synthase

metaR LAPCOAe
name: LAPCOAe
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA catabolism EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
fast: false
reactant: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110052#_c12a4ef9_4168_4c2c_a036_f098bd10859a
constant: false
name: B4GALT3
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8703
is: SBO:0000252
is: A8K5Z0
boundary condition: true
has only substance units: false

metaR EX pydam LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Pyridoxamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_78e00232_5e89_46e2_97da_c1d024f01f0f
is encoded by: hsa:AI697028
is: SBO:0000252
has only substance units: false
name: _AI697028_1_m
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
constant: false

metaR r2358
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110052#
type: Reaction
is: SBO:0000185

metaM camp c
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
name: 3',5'-cyclic AMP(1-)
has only substance units: false
constant: false
is: CHEBI:58165
is: HMDB00058

metaM HC01115 c
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: NeuNGc
initial amount: NaN
boundary condition: false
is: CHEBI:29025
type: Species
constant: false

metaR NACHEXA17ly
is described by: ECO:0000000
modifier: MODEL1310110052#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase A, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
product: MODEL1310110052#
reactant: MODEL1310110052#
reversible: false
kinetic law: MODEL1310110052#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_c7f3e081_f0dd_4c22_a5e1_f6e327c7f43f
is: Q9H3S5
is encoded by: hsa:93183
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
name: PIGM
constant: false
is: SBO:0000252

metaM ethamp r
name: O-phosphonatoethanaminium(1-)
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:58190
is: HMDB00224
initial concentration: 1.0
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
has only substance units: false
constant: false

metaR HAS1
product: MODEL1310110052#
modifier: MODEL1310110052#
reversible: false
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.212
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
type: Reaction
reactant: MODEL1310110052#
name: hyaluronan synthase
is: SBO:0000185

metaR r0365
modifier: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
fast: false
reversible: false
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000176
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
is version of: http://identifiers.org/ec-code/1.3.1.72

metaM acetone m
is: HMDB01659
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:15347
name: acetone
has only substance units: false

metaM strdnc c
name: stearidonic acid C18:4, n-3
is: http://identifiers.org/pubchem.compound/47205608
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: HMDB06547
is: SBO:0000247
has only substance units: false
is: C16300
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN

metaR MM8Ber
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (11253.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10409699,PMID:9592125 NOTES:NCD
kinetic law: MODEL1310110052#
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.2.1.113
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, endoplasmic reticulum
product: MODEL1310110052#

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaR r2357
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110052#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110052#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_adea899e_847a_41c2_9a43_257ded40ae06
constant: false
is: O75874
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3417
type: Species
boundary condition: true
is: SBO:0000252
name: IDH1

metaR ACACT1rm
modifier: MODEL1310110052#
name: acetyl-CoA C-acetyltransferase, mitochondrial
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110052#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
kinetic law: MODEL1310110052#
is: SBO:0000176
is described by: ECO:0000000

metaR r0437
kinetic law: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.2.13
is: SBO:0000176
modifier: MODEL1310110052#
fast: false
reversible: true
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
reactant: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:

metaR LPASE
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: lysophospholipase
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.5
notes: GENE_ASSOCIATION: (5321.1) or (1178.1) or (29124.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9430701 NOTES:phosphatidyl choline degradation NJ
reactant: MODEL1310110052#
modifier: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction

metaR AG13T3g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110052#
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110052#_b5007532_baba_4002_a545_d97b67d96bde
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:5281
is: SBO:0000252
name: PIGF
constant: false
initial amount: NaN
is: Q07326
initial concentration: NaN

metaR r2142
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110052#
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaM pail4p hs n
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: CHEBI:58178
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277

metaR C10CRNe
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decanoyl carnitine into extra cellular space
type: Reaction

metaR r2356
reactant: MODEL1310110052#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
kinetic law: MODEL1310110052#
reversible: true
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_dfddcbda_6c6d_45f3_9bd6_2d56cea208a8
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:84720
initial concentration: NaN
is: SBO:0000252
name: PIGO
initial amount: NaN
is: Q8TEQ8

http://identifiers.org/biomodels.db/MODEL1310110052#_ab698a0d_3abf_4b3f_8828_aafb63333121
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
name: _AD000092_1_c
initial concentration: NaN
is encoded by: hsa:AD000092
constant: false

metaM arachdcoa c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57368
constant: false
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: HMDB06523
has only substance units: false
name: arachidonoyl-CoA(4-)
type: Species
is: SBO:0000247

metaR ADRNCPT1
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000176
type: Reaction
fast: false
name: carnitine O-palmitoyltransferase
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110052#
modifier: MODEL1310110052#

metaM clpn hs c
boundary condition: false
notes: FORMULA: CHARGE: 0
is: CHEBI:21338
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
name: clpn_hs[c]
initial concentration: 1.0
is: HMDB02704
type: Species

metaR RE3269C
name: RE3269
is described by: ECO:0000000
reactant: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.3.48
reversible: true
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_8a62abb2_8ae0_4206_98e2_1ca680461bb2
is encoded by: hsa:23539
is: O95907
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
name: SLC16A8
is: SBO:0000252
initial amount: NaN

metaR MECOAS1m
is described by: ECO:0000304
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
name: mesaconate--CoA ligase (GDP-forming)
product: MODEL1310110052#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.4
fast: false
type: Reaction

metaR GULLACter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES:NCD
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110052#
name: gulonolactone endoplasmic reticular transport
reversible: false
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000185

metaR r2141
kinetic law: MODEL1310110052#
product: MODEL1310110052#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
is: SBO:0000185
modifier: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000

metaM strdnc e
is: HMDB06547
name: stearidonic acid C18:4, n-3
is: SBO:0000247
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: C16300
boundary condition: false
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205608

metaM cs b deg1 l
initial amount: NaN
type: Species
is: SBO:0000247
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
is: CHEBI:57455
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
is: HMDB01354
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false

metaR r2355
product: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#
is: SBO:0000185
kinetic law: MODEL1310110052#
fast: false
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110052#_89ad8624_0a55_4c22_bc5d_4ec8f69ba6e4
is: P60891
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
name: PRPS1
is encoded by: hsa:5631
has only substance units: false

metaM meoh c
is: CHEBI:17790
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
name: methanol
initial concentration: 1.0
boundary condition: false
is: HMDB01875
constant: false
type: Species

metaR ADRNCPT2
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
modifier: MODEL1310110052#
is: SBO:0000176
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
product: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#

metaR r0002
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
kinetic law: MODEL1310110052#
fast: false
reversible: true
reactant: MODEL1310110052#
is: SBO:0000185
product: MODEL1310110052#
name: Active transport

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_baf2a005_d311_4226_a3e8_696292cb84b9
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:55512
initial concentration: NaN
name: SMPD3
boundary condition: true
is: A8K0T6
type: Species

metaR DHFtm
kinetic law: MODEL1310110052#
name: dihydrofolate reversible mitochondrial transport
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reversible: true
fast: false
product: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_7c01ea1d_5972_4bec_b4a2_9a86d009d2e7
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:515
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is: SBO:0000297
boundary condition: true

metaM thymd e
is: C00214
constant: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
name: Thymidine
boundary condition: false
is: HMDB00273
is: CHEBI:17748
initial concentration: 1.0
is: SBO:0000247

metaM mlthf m
type: Species
initial amount: NaN
is: C00143
is: SBO:0000247
boundary condition: false
has only substance units: false
name: 5,10-Methylenetetrahydrofolate
constant: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: HMDB01533
initial concentration: 1.0
is: CHEBI:15636

http://identifiers.org/biomodels.db/MODEL1310110052#_14f9ebcc_9f54_4d27_939c_45affa249e9a
name: _AU149534_1_m
is encoded by: hsa:AU149534
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species

metaM CE0849 m
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:57795
name: cis,cis-palmito-7,10-dienoyl-CoA
boundary condition: false
type: Species
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
initial concentration: 1.0
initial amount: NaN

metaR FACOAL244 1
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
fast: false
reactant: MODEL1310110052#
name: fatty-acid--CoA ligase
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110052#

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaM taur x
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00251
name: taurine
is: CHEBI:15891
boundary condition: false
is: SBO:0000247
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
type: Species
initial concentration: 1.0

metaM lnlc r
is: CHEBI:30245
boundary condition: false
constant: false
name: linoleate
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00673
initial amount: NaN
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
initial concentration: 1.0

metaR PCRNtc
reversible: false
name: transport into the cytosol from peroxisome (carnitine)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
kinetic law: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
is: SBO:0000185
type: Reaction
product: MODEL1310110052#

metaM pep m
name: Phosphoenolpyruvate
has only substance units: false
is: C00074
constant: false
initial amount: NaN
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
is: CHEBI:18021
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00263
type: Species

metaR FATP8t
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110052#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.7
reactant: MODEL1310110052#
name: fatty acid electroneutral transport
modifier: MODEL1310110052#
product: MODEL1310110052#
fast: false
is: SBO:0000185
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR FAOXC204
kinetic law: MODEL1310110052#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
fast: false
modifier: MODEL1310110052#
name: Beta oxidation of long chain fatty acid
product: MODEL1310110052#
reactant: MODEL1310110052#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM 2dp6mobq m
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C57H86O3 CHARGE: 0 INCHI: InChI=1S/C57H86O3/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58)43-56(60-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
name: 2-decaprenyl-6-methoxy-1,4-benzoquinone
is: CHEBI:50773
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false

metaM C02528 r
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
name: chenodeoxycholate
constant: false
is: CHEBI:36234
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00518

metaM HC00460 c
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
name: 2,5-dihydroxybenzoate
has only substance units: false
is: CHEBI:58044
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR 34DHXMANDACOX
modifier: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
notes: GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
is described by: ECO:0000269
reversible: false
type: Reaction

metaM prostgf2 e
initial concentration: 1.0
is: CHEBI:57404
is: SBO:0000247
name: prostaglandin F2alpha(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
boundary condition: false
type: Species
initial amount: NaN
is: HMDB01139
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_4aa86340_c178_47d5_8709_193558cfb0ff
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:64077
name: LHPP
is: Q9H008
type: Species

metaM dcsptn1 e
type: Species
name: docosa-4,7,10,13,16-pentaenoic acid
boundary condition: false
is: http://identifiers.org/pubchem.compound/5282848
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
is: HMDB13123

metaM thymd c
is: SBO:0000247
has only substance units: false
is: C00214
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
name: Thymidine
boundary condition: false
initial concentration: 1.0
is: HMDB00273
is: CHEBI:17748

metaR S6TASE9ly
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: true
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_77e9304f_4fa4_4e2e_b476_82014558cb84
type: Species
is encoded by: hsa:8659
initial concentration: NaN
constant: false
name: ALDH4A1
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is: P30038

metaM ptdcacrn m
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
is: CHEBI:18303
constant: false
name: pendtadenoyl carnitine
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR r0360
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.16
is described by: ECO:0000000
fast: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
type: Reaction
reactant: MODEL1310110052#
is: SBO:0000176
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#

metaR 3AIBtm
modifier: MODEL1310110052#
name: 3-amino-isobutyrate transport, mitochondrial
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.6.1.19
reactant: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110052#
reversible: false
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110052#_8a5202dc_5009_4acc_83c0_218dc1037f53
constant: false
type: Species
initial concentration: NaN
has only substance units: false
name: GCH1
initial amount: NaN
boundary condition: true
is: Q8IZH9
is encoded by: hsa:2643
is: SBO:0000252

metaM dcyt c
constant: false
initial concentration: 1.0
is: SBO:0000247
name: Deoxycytidine
is: HMDB00014
boundary condition: false
is: C00881
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
has only substance units: false
type: Species
is: CHEBI:15698
initial amount: NaN

metaM prostgf2 c
boundary condition: false
type: Species
is: CHEBI:57404
name: prostaglandin F2alpha(1-)
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01139

http://identifiers.org/biomodels.db/MODEL1310110052#_c58c6118_74f4_4b42_a4c3_beeaae5115c4
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:376497
initial concentration: NaN
boundary condition: true
name: SLC27A1

http://identifiers.org/biomodels.db/MODEL1310110052#_ffd1de83_7770_44f5_b98d_c7c863f2ecc3
initial amount: NaN
boundary condition: true
is: P32189
is encoded by: hsa:2710
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: GK
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_530bea70_bfc1_47a5_86f8_7030fb5ffe13
is encoded by: hsa:4717
constant: false
initial amount: NaN
boundary condition: true
name: NDUFC1
is: O43677
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species

metaM L2aadp6sa c
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
name: L-allysine
is: HMDB01263
is: SBO:0000247
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
is: CHEBI:17917
type: Species

metaM decdp c
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
name: all trans Decaprenyl diphosphate
type: Species
notes: FORMULA: C50H81O7P2 CHARGE: -3 INCHI: InChI=1/C50H90O7P2/c1-41(2)21-31-53-58(51,54-32-22-42(3)4)57-59(52,35-25-45(9)10,36-26-46(11)12,37-27-47(13)14,38-28-48(15)16,39-29-49(17)18,40-30-50(19)20,55-33-23-43(5)6)56-34-24-44(7)8/h21-30H,31-40H2,1-20H3
is: SBO:0000247
initial concentration: 1.0
is: HMDB06288

metaR r0119
is version of: http://identifiers.org/ec-code/5.1.3.14
reactant: MODEL1310110052#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
kinetic law: MODEL1310110052#
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
product: MODEL1310110052#
reversible: false
is: SBO:0000176
modifier: MODEL1310110052#

metaR r2359
reactant: MODEL1310110052#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110052#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reversible: true

metaM ocdcea l
type: Species
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9- HEPATONET_1.0_ABBREVIATION: HC00510 EHMN_ABBREVIATION: C00712
initial concentration: 1.0
boundary condition: false
is: CHEBI:30823
is: SBO:0000247
initial amount: NaN
name: oleate
constant: false
is: HMDB00207

http://identifiers.org/biomodels.db/MODEL1310110052#_0ba35625_e724_429b_af95_d61d75e45c81
boundary condition: true
is encoded by: hsa:518
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
type: Species
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_a8fd6e70_e24f_4efc_9fbc_621ce74382dc
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
name: ST3GAL3
constant: false
is encoded by: hsa:6487

metaM 4mptnl c
has only substance units: false
is: HMDB01318
name: 4-methylpentanal
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
initial amount: NaN
type: Species
is: CHEBI:17998
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR r2095
modifier: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110052#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110052#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true

metaR r2371
reactant: MODEL1310110052#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110052#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
type: Reaction
is: SBO:0000185

metaM 6pgl r
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
is: HMDB01127
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
constant: false
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:57955

metaR FAOXC150m
fast: false
modifier: MODEL1310110052#
is: SBO:0000176
reactant: MODEL1310110052#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of long chain fatty acid (odd chain)
is described by: ECO:0000269
product: MODEL1310110052#

metaR GALSIDEtg
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
name: galactocerebroside intracellular transport
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#
is: SBO:0000185
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110052#_f3b43cc9_29d6_46fd_8a5b_32df58e65e0d
is: P50226
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:6799
boundary condition: true
name: SULT1A2
initial concentration: NaN

metaR r0570
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.3.2
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reversible: true
fast: false
product: MODEL1310110052#
reactant: MODEL1310110052#
modifier: MODEL1310110052#

metaR FADtx
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110052#
name: FAD transporter, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ

metaM 3htdcoa m
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
name: (S)-3-Hydroxytetradecanoyl-CoA
is: SBO:0000247
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
is: HMDB02288

metaR r2372
type: Reaction
kinetic law: MODEL1310110052#
is described by: ECO:0000000
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: true

metaR r2094
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: true
modifier: MODEL1310110052#
is described by: ECO:0000000

metaR DURIt
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
name: deoxyuridine transport via diffusion
is: SBO:0000185
product: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#

metaM ddece1crn c
notes: FORMULA: C19H35NO4 CHARGE: 0
name: dodecenoyl carnitine
initial amount: NaN
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB03712

metaR r0791
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110052#

metaM ksii core2 pre4 g
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 4
notes: FORMULA: C53H86N4O38X CHARGE: -1
is: C00130
is: SBO:0000247
is: CHEBI:58053
initial amount: NaN
has only substance units: false
constant: false

metaR CO2ter
kinetic law: MODEL1310110052#
fast: false
type: Reaction
reactant: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000185
name: CO2 endoplasmic reticular transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true

metaM ksi pre4 g
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
name: keratan sulfate I biosynthesis, precursor 4
constant: false
notes: FORMULA: C101H165N7O72X CHARGE: -1
is: HMDB00175
has only substance units: false
is: CHEBI:58053
is: C00130

metaR r0571
is described by: ECO:0000000
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.17 Confidence Level: 0 AUTHORS: PMID:3071714,PMID:6885824 NOTES:
name: (S)-Methylmalonyl-CoA hydrolase Propanoate metabolism EC:3.1.2.17
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.5.1.8
modifier: MODEL1310110052#
fast: false
product: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_25983324_1fec_415d_a39c_e9538760708f
is: P15121
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
name: AKR1B1
initial concentration: NaN
is encoded by: hsa:231
constant: false

metaR r2093
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110052#
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
modifier: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

metaR IDPtn
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
is: SBO:0000185
reversible: true
name: IDP nuclear transport
product: MODEL1310110052#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_bea43876_87fd_4c5d_b5c6_3b1126c507b6
constant: false
name: CLC
is encoded by: hsa:1178
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: C5HZ13
initial concentration: NaN
has only substance units: false

metaR r2373
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110052#
reversible: true
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000

metaM 4mptnl e
is: HMDB01318
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
has only substance units: false
initial amount: NaN
name: 4-methylpentanal
constant: false
is: SBO:0000247
type: Species
is: CHEBI:17998
initial concentration: 1.0
boundary condition: false

metaM ps hs c
name: ps_hs[c]
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:18303

metaM datp n
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
type: Species
is: SBO:0000247
has only substance units: false
name: dATP
boundary condition: false
is: CHEBI:61404
is: C00131
is: HMDB01532
constant: false
initial concentration: 1.0
initial amount: NaN

metaR EX 3tdcrn
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-tetradecanoyl carnitine
type: Reaction

metaR G14T14g
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
reversible: false
is: SBO:0000176
modifier: MODEL1310110052#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

http://identifiers.org/biomodels.db/MODEL1310110052#_91dde179_857c_4bc2_b50b_31a432726a2a
initial concentration: NaN
is encoded by: hsa:9091
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
type: Species
name: PIGQ
is: Q9BRB3

metaR M13N2Tg
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
modifier: MODEL1310110052#
is: SBO:0000176
type: Reaction
reversible: false
reactant: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.101
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_3bea49c0_c92e_4e0b_a353_2c0c3c3715bc
has part: P15531
has part: P22392
type: Species
has only substance units: false
initial concentration: NaN
name: NME1:NME2
is encoded by: hsa:4831
initial amount: NaN
is encoded by: hsa:4830
is: SBO:0000297
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_ef294a23_300a_4c41_bc08_eacc74ede75e
initial concentration: NaN
constant: false
boundary condition: true
type: Species
name: DCXR
initial amount: NaN
is: SBO:0000252
is: Q7Z4W1
is encoded by: hsa:51181
has only substance units: false

metaR SERTHRNaEx
reversible: false
kinetic law: MODEL1310110052#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110052#
name: L-serine/L-threonine Na-dependent exchange (Ser-L in)
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
type: Reaction
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_e6210edb_c948_4ac3_ba59_412561b05a90
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:AI440329
initial amount: NaN
has only substance units: false
name: _AI440329_1_r
constant: false
boundary condition: true

metaM prostge1 c
type: Species
is: HMDB01442
constant: false
has only substance units: false
name: prostaglandin E1(1-)
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: CHEBI:57397
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR r2374
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: true
type: Reaction

metaR r2092
reversible: true
kinetic law: MODEL1310110052#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110052#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110052#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110052#

metaR r0792
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
is: SBO:0000176
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
product: MODEL1310110052#
reversible: true
type: Reaction
reactant: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#

metaM fol c
name: Folate
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C19H18N7O6 CHARGE: -1
is: HMDB00121
type: Species

metaM ksi deg36 l
type: Species
is: HMDB00143
constant: false
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
name: keratan sulfate I, degradation product 36
boundary condition: false
is: CHEBI:12936
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110052#_d677cb0c_0b32_42b5_a0d7_b7bb7a74c46b
type: Species
boundary condition: true
initial concentration: NaN
name: ACP2
constant: false
initial amount: NaN
is: SBO:0000252
is: E9PCI1
is encoded by: hsa:53
has only substance units: false

metaR CHOLt4
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
kinetic law: MODEL1310110052#
reversible: true
modifier: MODEL1310110052#
fast: false
type: Reaction
name: choline, sodium cotransport
reactant: MODEL1310110052#
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_dd449165_c279_4269_bdf7_58688046803a
initial concentration: NaN
is encoded by: hsa:5145
is: SBO:0000252
is: P16499
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
name: PDE6A

metaM 5htrp c
name: 5-hydroxy-L-tryptophan
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00472
type: Species
boundary condition: false
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
is: CHEBI:17780

metaR r0797
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
product: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
name: glycine N-choloyltransferase EC:2.3.1.65
is: SBO:0000176
reversible: true
modifier: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_9df58058_d23d_4365_bcf2_b936a6cc9469
initial amount: NaN
is: Q13011
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:1891
name: ECH1
is: SBO:0000252
type: Species

metaM ps hs e
name: phosphatidylserine
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18303
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
has only substance units: false

metaR BHBtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110052#
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
kinetic law: MODEL1310110052#
product: MODEL1310110052#

metaR r2091
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is: SBO:0000185
reversible: true
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110052#
fast: false
is described by: ECO:0000000

metaR r2375
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reversible: true
kinetic law: MODEL1310110052#
is: SBO:0000185
reactant: MODEL1310110052#
type: Reaction
product: MODEL1310110052#

metaM fald e
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01426
boundary condition: false
is: CHEBI:16842
constant: false
name: formaldehyde
is: SBO:0000247
type: Species

metaR PIK3
is version of: http://identifiers.org/ec-code/2.7.1.154
is: SBO:0000176
name: phosphatidylinositol 3-kinase
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
fast: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.137
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.1.153
reversible: false
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

metaR AICART
is: SBO:0000176
reversible: true
product: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
reactant: MODEL1310110052#
is described by: ECO:0000269
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.1.2.3
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_58e65ff3_86ed_40e8_9bb9_c201e5502a49
is encoded by: hsa:5296
has only substance units: false
has part: O00459
boundary condition: true
name: PIK3CA:PIK3R2
type: Species
has part: P42336
is: SBO:0000297
constant: false
is encoded by: hsa:5290
initial concentration: NaN
initial amount: NaN

metaM prostge1 e
boundary condition: false
is: HMDB01442
has only substance units: false
is: CHEBI:57397
type: Species
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
name: prostaglandin E1(1-)
initial concentration: 1.0
constant: false
initial amount: NaN

metaR r2376
reactant: MODEL1310110052#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM cs a deg4 l
is: HMDB01354
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
initial amount: NaN
is: SBO:0000247
is: CHEBI:57455
initial concentration: 1.0
notes: FORMULA: C31H49NO29S CHARGE: -2
type: Species
constant: false
boundary condition: false
has only substance units: false

metaM ddcacoa c
initial amount: NaN
is: HMDB03571
is: C01832
is: SBO:0000247
name: Dodecanoyl-CoA (n-C12:0CoA)
initial concentration: 1.0
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
boundary condition: false
is: CHEBI:57375
constant: false
has only substance units: false
type: Species

metaR r1809
name: Y+LAT2 Utilized transport
reversible: false
modifier: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110052#_80eef993_f51b_4a78_ad37_a707a8d7d5ac
initial concentration: NaN
name: SLC6A8
has only substance units: false
is: B4DIA3
is encoded by: hsa:6535
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
boundary condition: true

metaM nrpphr e
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
type: Species
is: CHEBI:33569
has only substance units: false
is: HMDB00216
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: Norepinephrine

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaM fol e
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00121
notes: FORMULA: C19H18N7O6 CHARGE: -1
name: Folate

metaR r2090
kinetic law: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110052#
reactant: MODEL1310110052#
modifier: MODEL1310110052#
is described by: ECO:0000000
fast: false
reversible: true

metaM dd2coa x
is: CHEBI:57330
is: SBO:0000247
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
name: trans-Dodec-2-enoyl-CoA
is: HMDB03712
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110052#_1368869f_2fc3_497e_8e39_16a6cd94de25
type: Species
has only substance units: false
is: P00390
boundary condition: true
name: GSR
initial amount: NaN
is encoded by: hsa:2936
is: SBO:0000252
initial concentration: NaN
constant: false

metaR r2377
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110052#
is: SBO:0000185
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110052#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110052#

metaR ARACHDt2
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
type: Reaction
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110052#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_df59ce14_b010_4e5d_a2a1_082c63287118
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: LDHD
constant: false
is encoded by: hsa:197257
has only substance units: false
type: Species
initial concentration: NaN
is: Q86WU2

http://identifiers.org/biomodels.db/MODEL1310110052#_552c8bbc_7890_49e1_9611_8c31938ede61
is encoded by: hsa:204
constant: false
is: P54819
initial amount: NaN
name: AK2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_ee7541aa_6e56_4182_b02f_4b9d6fad4703
name: DGKG
is encoded by: hsa:1608
initial concentration: NaN
constant: false
type: Species
is: P49619
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM 3m4hpga c
initial amount: NaN
is: HMDB04061
type: Species
constant: false
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
boundary condition: false
is: http://identifiers.org/pubchem.compound/7909
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: C05583

http://identifiers.org/biomodels.db/MODEL1310110052#_7ed9be6c_55fb_4189_9dcb_2c23e0f586e2
initial amount: NaN
boundary condition: true
is encoded by: hsa:4695
initial concentration: NaN
has only substance units: false
name: NDUFA2
is: O43678
type: Species
is: SBO:0000252
constant: false

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

metaR IMPD
name: IMP dehydrogenase
product: MODEL1310110052#
is: SBO:0000176
fast: false
modifier: MODEL1310110052#
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.205
type: Reaction
notes: GENE_ASSOCIATION: (3614.1) or (3615.1) or (3614.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.1.1.205 Confidence Level: 4 AUTHORS: PMID:16464785 NOTES:

metaM ocdcea e
name: octadecenoate (n-C18:1)
has only substance units: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1
is: HMDB00207
is: C00712
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:0

metaR AKR1D2
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
type: Reaction
fast: false
kinetic law: MODEL1310110052#
is: SBO:0000176
modifier: MODEL1310110052#
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.3
reactant: MODEL1310110052#
product: MODEL1310110052#

metaM fald c
type: Species
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB01426
is: CHEBI:16842
name: formaldehyde
constant: false

metaM L2aadp6sa m
is: CHEBI:17917
boundary condition: false
is: SBO:0000247
name: L-allysine
has only substance units: false
is: HMDB01263
constant: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
initial concentration: 1.0
type: Species
initial amount: NaN

metaR C6DCc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_d74698b6_9cf4_472e_a6ae_c1f0e64c32e2
is: P00441
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:6647
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
name: SOD1

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaM gsn c
initial amount: NaN
name: Guanosine
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: C00387
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: CHEBI:16750
is: HMDB00133
is: SBO:0000247
type: Species

metaR r2378
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110052#
type: Reaction
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000

metaR EX chtn LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chitin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_16ab38be_c614_41fe_b99d_d119d9b85824
name: CPT1B
is encoded by: hsa:1375
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q92523
initial concentration: NaN
constant: false
type: Species
initial amount: NaN

metaR FORtr
type: Reaction
kinetic law: MODEL1310110052#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: FOR transporter, endoplasmic reticulum
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: true
fast: false
is described by: ECO:0000000

metaM pep c
initial concentration: 1.0
is: C00074
constant: false
is: SBO:0000247
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
is: HMDB00263
name: Phosphoenolpyruvate
initial amount: NaN
boundary condition: false
is: CHEBI:18021
has only substance units: false
type: Species

metaR NACHEXA21ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
fast: false
kinetic law: MODEL1310110052#
type: Reaction
modifier: MODEL1310110052#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110052#
reversible: false
product: MODEL1310110052#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR r0796
product: MODEL1310110052#
is: SBO:0000176
modifier: MODEL1310110052#
reversible: true
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
fast: false
reactant: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
is described by: ECO:0000000

metaR r1749
modifier: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110052#
name: Y+LAT2 Utilized transport
product: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
reversible: false
is: SBO:0000185

metaR DRPA
reversible: false
kinetic law: MODEL1310110052#
is: SBO:0000176
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
name: deoxyribose-phosphate aldolase
reactant: MODEL1310110052#
product: MODEL1310110052#

metaR PIK4
is: SBO:0000176
modifier: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (5298.1) or (55361.1) or (5297.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.67 Confidence Level: 4 AUTHORS: PMID:12324459,PMID:164238,PMID:8662589 NOTES:NJ
reactant: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
name: phosphatidylinositol 4-kinase
reversible: false
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.1.67
fast: false

metaM 3octdece1crn c
type: Species
has only substance units: false
notes: FORMULA: C25H47NO5 CHARGE: 0
initial concentration: 1.0
is: HMDB13336
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
name: 3-hydroxy-octadecenoyl carnitine

metaR S6TASE22ly
is version of: http://identifiers.org/ec-code/3.2.1.23
name: galactose-6-sulfate sulfatase, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: true
product: MODEL1310110052#
reactant: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176

metaR r0423
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.2.1.3

metaR ME2m
kinetic law: MODEL1310110052#
name: malic enzyme (NADP), mitochondrial
is version of: http://identifiers.org/ec-code/1.1.1.40
modifier: MODEL1310110052#
reversible: false
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
product: MODEL1310110052#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.38
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_3db04e1e_da0c_4a23_b1d3_cf25e9c05c10
is: Q9Y6K8
initial concentration: NaN
constant: false
name: AK5
is encoded by: hsa:26289
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species

metaM crn x
is: HMDB00062
name: L-Carnitine
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: C00318
type: Species
is: CHEBI:16347
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

metaM utp n
name: UTP(4-)
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: CHEBI:46398
constant: false
type: Species
is: HMDB00285
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_1e33ae51_9e7b_44f3_9838_8dea0b02cc20
is encoded by: hsa:7166
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is: P17752
type: Species
boundary condition: true
name: TPH1
has only substance units: false

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaM ptdca e
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
constant: false
is: HMDB00826
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/22169126
has only substance units: false
initial amount: NaN
name: pentadecanoate
is: SBO:0000247
initial concentration: 1.0

metaR O2Stm
name: superoxide anion transport via diffusion (mitochondria)
reversible: true
is described by: ECO:0000000
product: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110052#

metaR P4502C18
name: cytochrome P450 2C18
kinetic law: MODEL1310110052#
product: MODEL1310110052#
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1562.1) SUBSYSTEM: Cytochrome metabolism EC Number: 1.14.14.1 Confidence Level: 2 AUTHORS: PMID:15579107,PMID:8110777 NOTES:antipyrine N-demethylation assumed to take place on outer membrane stoichiometry inferred (methanol production vs methane production?) NJ
modifier: MODEL1310110052#
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.14.14.1

metaM phyt x
type: Species
boundary condition: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
is: CHEBI:37257
constant: false
initial amount: NaN
name: phytanate
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00801

http://identifiers.org/biomodels.db/MODEL1310110052#_92efad2e_8d6c_49f4_b84a_cd5aabdaacff
constant: false
is: P57054
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:51227
boundary condition: true
name: PIGP
type: Species
has only substance units: false

metaR IMPC
is: SBO:0000176
fast: false
is described by: ECO:0000269
name: IMP cyclohydrolase
modifier: MODEL1310110052#
reactant: MODEL1310110052#
reversible: true
type: Reaction
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.1.2.3
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:

metaR r0578
is described by: ECO:0000000
reactant: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/4.1.2.27
fast: false
modifier: MODEL1310110052#
reversible: true
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
type: Reaction
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_9c8682ad_7607_412a_b7fd_f2bcbd87591f
is: SBO:0000252
is: O43916
is encoded by: hsa:8534
has only substance units: false
type: Species
initial amount: NaN
name: CHST1
constant: false
initial concentration: NaN
boundary condition: true

metaR RE3005M
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110052#
name: RE3005
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#

metaR 3MOX4HOXPGALDOX NADP
reversible: true
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110052#
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase
is described by: ECO:0000304
type: Reaction
product: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR r0641
fast: false
modifier: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
reversible: true
is: SBO:0000176
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.2.4

metaM 3octdece1crn e
is: SBO:0000247
name: 3-hydroxy-octadecenoyl carnitine
boundary condition: false
is: HMDB13336
initial concentration: 1.0
type: Species
notes: FORMULA: C25H47NO5 CHARGE: 0
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_b98dd9e9_b230_488a_881a_97b1998c2e74
name: SLC17A1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:6568
type: Species
boundary condition: true
initial amount: NaN
is: Q14916

http://identifiers.org/biomodels.db/MODEL1310110052#_2ce4eb3f_e96b_4740_962b_3fb448825816
boundary condition: true
has only substance units: false
is: B4E0V8
initial concentration: NaN
constant: false
is encoded by: hsa:3034
is: SBO:0000252
type: Species
initial amount: NaN
name: HAL

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_3e52f2a7_0be1_4055_9541_bf26d50193f0
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:10935
boundary condition: true
is: SBO:0000252
name: PRDX3
type: Species
is: E9PH29
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_1202e89e_324a_4c96_b8ec_e98d02aca317
type: Species
initial concentration: NaN
name: CHAT
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1103
is: D3DX95

metaR NMNATr
type: Reaction
modifier: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
product: MODEL1310110052#
is: SBO:0000176
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
reversible: true
name: nicotinamide-nucleotide adenylyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.1
kinetic law: MODEL1310110052#

metaR KSIt
is: SBO:0000185
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
name: keratan sulfate I transport, golgi to extracellular
fast: false
reactant: MODEL1310110052#
reversible: false
kinetic law: MODEL1310110052#

metaR LYStiDF
reversible: false
fast: false
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
name: L-lysine transport via diffusion (extracellular to cytosol)
product: MODEL1310110052#

metaM doldp L r
type: Species
is: CHEBI:15750
constant: false
notes: FORMULA: C1080H1758O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
is: SBO:0000247
name: Dolichol diphosphate, human liver homolog
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR r0579
product: MODEL1310110052#
modifier: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/1.13.11.19
kinetic law: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176

metaR RE3567C
name: RE3567
product: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110052#
is: SBO:0000176

metaR UMPK6n
is: SBO:0000176
product: MODEL1310110052#
is described by: ECO:0000269
modifier: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (dCTP),nuclear
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
type: Reaction
reactant: MODEL1310110052#

metaM 4mptnl m
name: 4-methylpentanal
boundary condition: false
type: Species
constant: false
is: CHEBI:17998
initial concentration: 1.0
is: HMDB01318
is: SBO:0000247
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
has only substance units: false
initial amount: NaN

metaM 34dhoxmand m
is: CHEBI:27637
constant: false
name: 3,4-Dihydroxymandelate
initial amount: NaN
is: HMDB01866
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM ptdca c
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
type: Species
is: HMDB00826
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/22169126
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: pentadecanoate
constant: false

metaM ocdcea r
is: C00712
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00207
name: octadecenoate (n-C18:1)
initial concentration: 1.0
is: CHEBI:0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_99c6553b_a426_4cfe_a3f2_6e73609fd902
constant: false
is encoded by: hsa:4718
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: NDUFC2
is: Q549M5

metaM 2obut m
boundary condition: false
has only substance units: false
is: CHEBI:16763
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
type: Species
constant: false
name: 2-oxobutanoate
initial amount: NaN
is: HMDB00005

metaM T antigen g
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
name: T antigen (core 1)
is: CHEBI:22783
boundary condition: false
has only substance units: false
notes: FORMULA: C14H24NO10X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110052#_bf292ae4_b3de_4d2e_aca9_f86498aed478
constant: false
is: SBO:0000252
is: Q9UBY0
name: SLC9A2
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:6549

http://identifiers.org/biomodels.db/MODEL1310110052#_6bc3eb66_479b_45f0_b3af_fa5cdd811dec
is encoded by: hsa:23396
boundary condition: true
initial concentration: NaN
name: PIP5K1C
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is: O60331

metaR RE2625M
fast: false
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
is described by: ECO:0000000
name: RE2625
is: SBO:0000176
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15

metaR CORE2GTg
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110052#
is: SBO:0000176
reversible: false
type: Reaction
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110052#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.102
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_4734ce49_9b4f_4a28_be9a_20d45df242ba
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
name: PDE9A
has only substance units: false
is encoded by: hsa:5152
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_6417bcf3_6015_4514_995f_74caa7ae42aa
is: SBO:0000252
type: Species
has only substance units: false
name: DDC
initial concentration: NaN
initial amount: NaN
is: Q53Y41
is encoded by: hsa:1644
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_709ad1ea_0e4b_4580_9c3a_8485ed7df98e
type: Species
name: TPI1P2
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:286016
initial amount: NaN
initial concentration: NaN

metaR BUTt2r
is: SBO:0000185
type: Reaction
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
name: Butyrate transport via proton symport, reversible
reversible: true
reactant: MODEL1310110052#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110052#_82812171_cf44_42d2_ae62_d9c5eb8aa269
name: SLC11A2
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4891
constant: false
type: Species
boundary condition: true
is: B4DK84
initial concentration: NaN
initial amount: NaN

metaR RE2079R
is described by: ECO:0000000
kinetic law: MODEL1310110052#
name: RE2079
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
fast: false
product: MODEL1310110052#
type: Reaction
reversible: true
is: SBO:0000176

metaR AG13T16g
reversible: false
product: MODEL1310110052#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
fast: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110052#_8581cc30_2b77_4460_b2b4_384c7508eb60
name: _H17063_1_c
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:H17063
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_8d5e084e_1186_420a_a1a5_8d37ea07e6f5
name: PPAP2C
initial amount: NaN
is: E9PAY8
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:8612
has only substance units: false
initial concentration: NaN

metaM trdrd m
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
name: Reduced thioredoxin
is: CHEBI:15967

http://identifiers.org/biomodels.db/MODEL1310110052#_6b9f9a78_cc69_4cfe_93ae_b13705654bb4
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3295
is: E9PB82
name: HSD17B4
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_ebd416f7_ef94_49b0_a87d_806a61302311
is: P13073
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:1327
name: COX4I1
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252

metaM ps hs m
name: ps_hs[m]
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18303
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false

metaR 7DHCHSTEROLtr
reversible: true
reactant: MODEL1310110052#
is: SBO:0000185
name: cholesterol precursor intracellular transport
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110052#_e688a0c3_bd95_4f37_9705_388a509eb6d5
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
name: CRAT
is encoded by: hsa:1384
has only substance units: false
constant: false
initial amount: NaN

metaR MI1345PP
modifier: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#
type: Reaction
is described by: ECO:0000269
fast: false
reversible: false
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.3.56
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.36
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.86

metaM odecoa c
is: HMDB01322
is: SBO:0000247
constant: false
is: CHEBI:3793
boundary condition: false
initial concentration: 1.0
name: Octadecenoyl-CoA (n-C18:1CoA)
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_82eeb3f3_a4c6_4093_b3cb_72f000f8d96c
initial amount: NaN
type: Species
is encoded by: hsa:10005
boundary condition: true
name: ACOT8
has only substance units: false
is: O14734
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_48e4f5b4_57bb_4aa1_80e2_5b54bfaf41ea
type: Species
boundary condition: true
has only substance units: false
name: AKR1D1
initial concentration: NaN
is: SBO:0000252
is: P51857
is encoded by: hsa:6718
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_7fb08231_0a1e_4cec_b98f_b545487dc5d9
is: Q9BWD1
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:39
is: SBO:0000252
name: ACAT2
boundary condition: true

metaR METtec
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reversible: true
product: MODEL1310110052#
is: SBO:0000185
modifier: MODEL1310110052#
is described by: ECO:0000269
name: L-methionine transport via diffusion (extracellular to cytosol)
fast: false
type: Reaction
reactant: MODEL1310110052#

metaM fol m
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00121
type: Species
name: Folate
notes: FORMULA: C19H18N7O6 CHARGE: -1 INCHI: InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00396 EHMN_ABBREVIATION: C00504
is: CHEBI:27470
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_b2aac390_78e5_400d_a206_9b07ba5090b7
is: SBO:0000252
is encoded by: hsa:4907
initial amount: NaN
constant: false
name: NT5E
has only substance units: false
is: P21589
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_1003e7d3_8601_4e63_b498_b00c8409b8b7
constant: false
name: AUH
initial amount: NaN
type: Species
is encoded by: hsa:549
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q13825

http://identifiers.org/biomodels.db/MODEL1310110052#_83365327_1827_4b51_9d40_1c1850bfac76
is: Q13613
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
constant: false
name: MTMR1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8776

http://identifiers.org/biomodels.db/MODEL1310110052#_2caa27fe_da1f_439d_8660_eecf01456626
name: SHMT1
constant: false
is encoded by: hsa:6470
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_b9b40718_616d_4e1b_b626_8800477c2f7c
is encoded by: hsa:79087
is: Q9BV10
type: Species
is: SBO:0000252
name: ALG12
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true

metaR r0860
is: SBO:0000185
modifier: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
reversible: true
type: Reaction
name: Utilized transport
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.1.2.27

metaM 34dhmald m
has only substance units: false
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/7903
is: C05577
constant: false
name: 3,4-Dihydroxymandelaldehyde
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: HMDB06242
initial amount: NaN

metaR r0575
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
kinetic law: MODEL1310110052#
fast: false
modifier: MODEL1310110052#
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.1.48
reversible: true
type: Reaction
reactant: MODEL1310110052#
is described by: ECO:0000000

metaM adn m
boundary condition: false
has only substance units: false
is: CHEBI:16335
constant: false
is: HMDB00050
initial amount: NaN
type: Species
is: SBO:0000247
name: adenosine
initial concentration: 1.0
notes: FORMULA: C10H13N5O4 CHARGE: 0 INCHI: InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212

http://identifiers.org/biomodels.db/MODEL1310110052#_6c4881cc_4c2e_4733_a8e5_d689c1c4e317
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:D87002
name: _D87002_1_m
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_c8e90cb3_6489_4dae_8822_019a0a9ed490
boundary condition: true
initial amount: NaN
name: ATP1B4:ATP1A2
type: Species
initial concentration: NaN
has only substance units: false
has part: Q9UN42
is: SBO:0000297
constant: false
is encoded by: hsa:23439
is encoded by: hsa:477
has part: P50993

metaM ksi deg17 l
is: SBO:0000247
constant: false
type: Species
is: HMDB00143
has only substance units: false
name: keratan sulfate I, degradation product 17
boundary condition: false
is: CHEBI:12936
initial amount: NaN
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
initial concentration: 1.0

metaR ADK3m
type: Reaction
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
product: MODEL1310110052#
modifier: MODEL1310110052#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.10
fast: false
name: adentylate kinase (GTP)
is described by: ECO:0000269
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110052#_9250a87c_913a_4a50_91f4_dd6f3f2a78b5
boundary condition: true
name: PDE9A
is encoded by: hsa:5152
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_ab00e751_51ce_4940_9ca7_616308c7ff0e
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:4710
has only substance units: false
is: O95168
name: NDUFB4
is: SBO:0000252

metaM cs e deg6 l
initial amount: NaN
has only substance units: false
is: HMDB01354
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6
type: Species
boundary condition: false
constant: false
is: CHEBI:57455
is: SBO:0000247
notes: FORMULA: C31H48NO32S2 CHARGE: -3

metaR O2Stn
type: Reaction
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
name: superoxide anion transport via diffusion (nucleus)
is described by: ECO:0000000
fast: false
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is: SBO:0000185
reversible: true

metaR NAtx
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
name: sodium transport via diffusion (perioxisome)
is: SBO:0000185
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_59c4c251_7fc9_4ebd_b5b7_e76af3189106
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q9BZ23
type: Species
name: PANK2
has only substance units: false
is encoded by: hsa:80025
is: SBO:0000252
constant: false

metaR PPItx
name: Diphosphate transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110052#
reversible: true
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_bcdd509f_883c_484d_99bc_f5002274f4ff
is: Q14117
initial amount: NaN
constant: false
name: DPYS
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:1807

metaR q10h2tc
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
type: Reaction
name: transport of ubiquinol into cytosol
kinetic law: MODEL1310110052#
is described by: ECO:0000134
product: MODEL1310110052#
is: SBO:0000185
reversible: true
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_c3bcad1b_653b_4f98_9c66_6b9617056bad
type: Species
name: ACOT2
constant: false
is encoded by: hsa:10965
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P49753

http://identifiers.org/biomodels.db/MODEL1310110052#_051b8144_7e0c_4cdf_b369_a2c6e4e3bf85
type: Species
boundary condition: true
is: P05091
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:217
name: ALDH2
constant: false
initial concentration: NaN

metaR NACHEXA18ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reactant: MODEL1310110052#
is: SBO:0000176
name: beta-N-acetylhexosaminidase A, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110052#
type: Reaction
modifier: MODEL1310110052#
fast: false
product: MODEL1310110052#
reversible: false
is described by: ECO:0000000

metaM lgnc e
name: lignocerate
initial concentration: 1.0
is: CHEBI:31014
boundary condition: false
is: SBO:0000247
is: HMDB02003
initial amount: NaN
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
has only substance units: false
constant: false
type: Species

metaM thcholstoic m
type: Species
is: CHEBI:18402
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB03873
boundary condition: false
is: SBO:0000247
has only substance units: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate

metaM spmd e
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:57834
boundary condition: false
is: C00315
is: HMDB01257
name: Spermidine
has only substance units: false

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaR PROSTGE2t
product: MODEL1310110052#
modifier: MODEL1310110052#
reversible: true
name: prostaglandin transport via bicarbonate countertransport
reactant: MODEL1310110052#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110052#
is: SBO:0000185
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
type: Reaction

metaR EX CE2250 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-oxodocosanoyl-CoA exchange
type: Reaction

metaM glyb m
constant: false
name: glycine betaine
is: HMDB00043
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:17750
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR FAOXC227C226m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_b45cf050_3c69_4d78_9415_80e91d682b61
initial concentration: NaN
is encoded by: hsa:NM 013421
type: Species
has only substance units: false
boundary condition: true
constant: false
name: _NM_013421_1_m
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_fefb6d4f_1a44_498e_b088_3b7af83fc1e1
constant: false
has only substance units: false
initial amount: NaN
is: O43272
is encoded by: hsa:5625
is: SBO:0000252
name: PRODH
type: Species
initial concentration: NaN
boundary condition: true

metaM adn c
type: Species
is: HMDB00050
has only substance units: false
is: CHEBI:16335
is: SBO:0000247
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: Adenosine
is: C00212
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_a8c0aca4_446c_4b03_88a1_93a676fc3074
is encoded by: hsa:2977
constant: false
is: P33402
name: GUCY1A2
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR CAATPS
product: MODEL1310110052#
is described by: ECO:0000269
reversible: false
type: Reaction
name: Ca ATPase
is: SBO:0000185
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.6.3.8
modifier: MODEL1310110052#
fast: false

metaM fad e
is: HMDB01248
constant: false
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:16238
initial amount: NaN
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: C00016
initial concentration: 1.0
name: Flavin adenine dinucleotide oxidized
boundary condition: false

metaR DURIPP
reactant: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.3
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110052#
name: deoxyuridine phosphorylase

metaR P450SCC1m
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
name: cholesterol monooxygenase
reactant: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000176
reversible: true
type: Reaction

metaM lgnc c
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: CHEBI:31014
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
is: SBO:0000247
is: HMDB02003
initial amount: NaN
has only substance units: false
name: lignocerate

metaR MM6B2g
modifier: MODEL1310110052#
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
is: SBO:0000176
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.113
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110052#_81b2f18e_9f10_4f36_acfa_686df2031ce9
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: O95954
is encoded by: hsa:10841
type: Species
constant: false
name: FTCD
boundary condition: true
initial concentration: NaN

metaR ITCOALm
is: SBO:0000176
is described by: ECO:0000212
kinetic law: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.4
fast: false
modifier: MODEL1310110052#
product: MODEL1310110052#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.5
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
reactant: MODEL1310110052#

metaM acgam r
initial amount: NaN
is: HMDB00215
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
boundary condition: false
constant: false
name: N-acetyl-D-glucosamine
is: CHEBI:17411
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR r0647
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110052#
is: SBO:0000176
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
kinetic law: MODEL1310110052#
reversible: true
name: Spontaneous reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_0d788ee9_5dbe_4e00_8d74_38bb5119a513
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: MYO5B
is encoded by: hsa:4645
is: Q9H6Y6
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_ef757c94_8458_4bfd_bcdf_11019bfbb8ed
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:220
constant: false
is: P47895
name: ALDH1A3
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM forglu c
is: CHEBI:18327
is: HMDB00854
initial amount: NaN
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
is: SBO:0000247
name: N-Formimidoyl-L-glutamate
has only substance units: false
boundary condition: false
is: C00439
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_bc491051_9fd3_437f_b02c_b9ecc8c6e533
initial concentration: NaN
is encoded by: hsa:54344
is: Q86TM7
name: DPM3
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaR PCHOLP hs
fast: false
is described by: ECO:0000269
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.4.4
product: MODEL1310110052#
name: choline phosphatase
modifier: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110052#_836eac2d_8be1_4e4a_8a48_bb83ba034f26
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
name: RDH14
is: SBO:0000252
initial concentration: NaN
is: Q9HBH5
type: Species
is encoded by: hsa:57665

http://identifiers.org/biomodels.db/MODEL1310110052#_b7971729_1c71_4eab_bcd2_a337b986dd64
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
name: PDE5A
is: SBO:0000252
is encoded by: hsa:8654

http://identifiers.org/biomodels.db/MODEL1310110052#_96eb0328_a64d_4421_85be_63fef9d97f2a
is encoded by: hsa:51205
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is: Q9NPH0
name: ACP6
initial amount: NaN
boundary condition: true

metaR PNTOte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#
type: Reaction
is: SBO:0000185
name: Transport of (R)-Pantothenate
is described by: ECO:0000134
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_da30bd05_cb3a_4b3c_95cf_3e71eb122b84
constant: false
initial amount: NaN
is: SBO:0000252
is: O00142
has only substance units: false
initial concentration: NaN
name: TK2
boundary condition: true
is encoded by: hsa:7084
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_d411686b_5beb_460e_b5d5_061443688444
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5295
initial concentration: NaN
name: PIK3R1
is: P27986
type: Species

metaR FADDPle
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.1
reversible: false
type: Reaction
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (5167.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110052#
is described by: ECO:0000134
kinetic law: MODEL1310110052#
is: SBO:0000176
name: FAD diphosphatase
product: MODEL1310110052#

metaR EX coa LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for coa
type: Reaction

metaR ACITL
modifier: MODEL1310110052#
name: ATP-Citrate lyase
type: Reaction
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
reversible: false
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.3.8
is: SBO:0000176
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110052#

metaM h2o x
type: Species
initial amount: NaN
constant: false
name: H2O
is: SBO:0000247
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
is: C00001
is: HMDB02111
has only substance units: false
boundary condition: false

metaR C10DCCACT
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacoyl carnitine into cytosol
type: Reaction

metaR RE0569E
kinetic law: MODEL1310110052#
reversible: false
modifier: MODEL1310110052#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (4017.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
product: MODEL1310110052#
type: Reaction
name: RE0569
is: SBO:0000176
reactant: MODEL1310110052#

metaR r1811
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
fast: false
reversible: false
is: SBO:0000185
reactant: MODEL1310110052#

metaR ACNAMPH
is: SBO:0000176
name: N-Acetylneuraminate 9-phosphate phosphohydrolase
is described by: ECO:0000000
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110052#
type: Reaction
reversible: false
reactant: MODEL1310110052#
fast: false

metaR PTPATe
reversible: true
kinetic law: MODEL1310110052#
is: SBO:0000176
name: PTPATe
reactant: MODEL1310110052#
product: MODEL1310110052#
fast: false
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110052#_42709596_4712_40fd_8fd6_ce203ffc9b2d
initial amount: NaN
is: SBO:0000252
name: _AL525798_1_c
is encoded by: hsa:AL525798
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_998907b5_460b_43f4_b7c7_ea656b173e17
has only substance units: false
initial amount: NaN
boundary condition: true
name: HSD11B1
is: P28845
is: SBO:0000252
type: Species
is encoded by: hsa:3290
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_c48c493b_7136_4c2c_b38d_6b85dd26f89e
name: GBA
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:2629
boundary condition: true
is: B7Z6S9

metaR S2L2N2M2MASNtly
kinetic law: MODEL1310110052#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
name: s2l2n2m2masn transport, extracellular to lysosome
reactant: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110052#

metaM mercplac c
is: C05823
is: SBO:0000247
type: Species
is: HMDB02127
has only substance units: false
boundary condition: false
initial amount: NaN
name: 3-Mercaptolactate
constant: false
initial concentration: 1.0
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
is: http://identifiers.org/pubchem.compound/8118

http://identifiers.org/biomodels.db/MODEL1310110052#_3a4bfb3d_d9c1_4050_b99c_ef2575fcd71d
name: ETFB
boundary condition: true
is: P38117
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2109
constant: false

metaR ARACHDCOAtx
type: Reaction
reactant: MODEL1310110052#
is described by: ECO:0000000
name: fatty acid intracellular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110052#
is: SBO:0000185
product: MODEL1310110052#
reversible: true

metaR PNTEH
reversible: false
name: Hydrolase Class ( RXN R02973)
modifier: MODEL1310110052#
type: Reaction
is: SBO:0000176
product: MODEL1310110052#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
is version of: http://identifiers.org/ec-code/3.5.1.92
reactant: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_4a212d7c_4e13_419a_84d1_0216660f3274
initial concentration: NaN
boundary condition: true
is encoded by: hsa:53354
initial amount: NaN
name: PANK1
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is: Q8TE04

metaR OMHPALTD
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

metaR C12DCTD
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Dodecanedioic acid by diffusion
type: Reaction

metaM ivcrn e
is: HMDB00688
is: SBO:0000247
initial concentration: 1.0
name: isovaleryl carnitine
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C12H23NO4 CHARGE: 0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_16658655_e800_43dd_9dc7_3623d4e93ee0
constant: false
is: SBO:0000297
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:9551
is encoded by: hsa:522
has part: P56134

http://identifiers.org/biomodels.db/MODEL1310110052#_99d5570f_ca94_472a_a50d_ba66ac822efc
name: GPX4
initial amount: NaN
is: P36969
boundary condition: true
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2879

metaR O2Stx
product: MODEL1310110052#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110052#
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reactant: MODEL1310110052#
name: superoxide anion transport via diffusion (peroxisome)

metaM cs a deg5 l
initial concentration: 1.0
is: CHEBI:15936
type: Species
is: SBO:0000247
notes: FORMULA: C23H36O24S CHARGE: -2
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5

metaR EX c51crn
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

metaR FUCASE2ly
name: alpha-fucosidase, lysosomal
reactant: MODEL1310110052#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.51
reversible: false
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
product: MODEL1310110052#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_f2712add_a803_4b88_acd5_714bb26c8dc0
type: Species
is: P28331
name: NDUFS1
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:4719
initial amount: NaN

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

metaR r0644
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
fast: false
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110052#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110052#_929dd171_144a_41f4_a73d_b23f89aefcd1
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2180
is: P33121
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: ACSL1
constant: false

metaM sT antigen g
is: CHEBI:16565
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C25H40N2O18X CHARGE: -1
type: Species
name: sialyl-T antigen
has only substance units: false
initial concentration: 1.0

metaR BALAtmr
fast: false
kinetic law: MODEL1310110052#
type: Reaction
reversible: true
product: MODEL1310110052#
name: Beta-alanine reversible mitochondrial transport (diffusion)
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
reactant: MODEL1310110052#

metaM uacgam g
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:57705
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
boundary condition: false
is: SBO:0000247
is: HMDB00290
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
initial amount: NaN

metaM pcrn m
initial concentration: 1.0
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
name: propionyl-carnitine
is: HMDB00824
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/107738
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
type: Species

metaR S6T7g
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: false
modifier: MODEL1310110052#
fast: false

metaR r0355
is: SBO:0000176
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
reversible: false
reactant: MODEL1310110052#
modifier: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.3
kinetic law: MODEL1310110052#
fast: false

metaR PPItr
is described by: ECO:0000000
fast: false
reactant: MODEL1310110052#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110052#
name: Diphosphate transporter, endoplasmic reticulum
reversible: true
kinetic law: MODEL1310110052#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_eebaa518_3f47_4124_be4f_c426e8d56eb6
is encoded by: hsa:2645
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: GCK

metaR RE2626C
type: Reaction
reactant: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
name: RE2626
is described by: ECO:0000000
product: MODEL1310110052#
reversible: true
is: SBO:0000176

metaR CHOLATEt
is described by: ECO:0000269
modifier: MODEL1310110052#
reactant: MODEL1310110052#
name: cholate transport via bicarbonate countertransport
product: MODEL1310110052#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
type: Reaction
fast: false

metaR EX meoh LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: methanol exchange
type: Reaction

metaM methf m
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
name: (6R)-5,10-methenyltetrahydrofolate
is: HMDB01354
is: CHEBI:57455
constant: false
has only substance units: false
initial amount: NaN

metaM ivcrn c
has only substance units: false
is: HMDB00688
type: Species
notes: FORMULA: C12H23NO4 CHARGE: 0
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: isovaleryl carnitine
boundary condition: false

metaR r0643
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
is described by: ECO:0000000
type: Reaction
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
kinetic law: MODEL1310110052#
fast: false
is: SBO:0000176
reactant: MODEL1310110052#
product: MODEL1310110052#

metaR FAOXC163C164Gm
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

metaR FACOAL245 1
name: fatty-acid--CoA ligase
type: Reaction
kinetic law: MODEL1310110052#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110052#
is: SBO:0000176
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_eec866ee_eae4_42c5_b609_7454879d84ed
initial amount: NaN
name: AK2
is encoded by: hsa:204
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_a2fe3f6a_2038_4b28_aec7_c09848dffd6d
is: P15328
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2348
boundary condition: true
is: SBO:0000252
name: FOLR1
constant: false

metaR GLYK
fast: false
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.1.30
type: Reaction
product: MODEL1310110052#
is described by: ECO:0000269
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (2710.2) or (2712.1) or (2710.1) or (2713.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: glycerol kinase
is: SBO:0000176
reversible: false

metaM e4p c
has only substance units: false
is: HMDB01321
is: C00279
is: CHEBI:16897
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: D-Erythrose 4-phosphate
type: Species
boundary condition: false
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279

metaM crn r
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial amount: NaN
is: HMDB00062
type: Species
constant: false
boundary condition: false
has only substance units: false
name: (R)-carnitine
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16347

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaR GALASE9ly
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
product: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110052#
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
is: SBO:0000176

metaR r0642
kinetic law: MODEL1310110052#
fast: false
reversible: true
reactant: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
type: Reaction
product: MODEL1310110052#
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
is: SBO:0000176

metaM odecoa m
type: Species
has only substance units: false
boundary condition: false
name: Octadecenoyl-CoA (n-C18:1CoA)
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB01322
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
is: CHEBI:57387

http://identifiers.org/biomodels.db/MODEL1310110052#_759b849a_24dd_4d17_84cb_76d76ed3c931
is: SBO:0000252
boundary condition: true
constant: false
is: P52788
is encoded by: hsa:6611
has only substance units: false
name: SMS
initial concentration: NaN
initial amount: NaN
type: Species

metaM fad c
boundary condition: false
is: C00016
type: Species
initial concentration: 1.0
is: HMDB01248
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: CHEBI:16238
constant: false
has only substance units: false
name: Flavin adenine dinucleotide oxidized
is: SBO:0000247
initial amount: NaN

metaR FACOAL245 2
fast: false
kinetic law: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110052#
reactant: MODEL1310110052#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110052#
is described by: ECO:0000269
is: SBO:0000176
name: fatty-acid--CoA ligase

metaM adn e
name: Adenosine
boundary condition: false
is: CHEBI:16335
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
constant: false
type: Species
is: HMDB00050
initial concentration: 1.0
is: C00212

metaM c3dc e
has only substance units: false
type: Species
name: malonyl carnitine
initial amount: NaN
is: SBO:0000247
is: HMDB02095
notes: FORMULA: C10H16NO6 CHARGE: -1
boundary condition: false
constant: false
initial concentration: 1.0

metaM but e
is: SBO:0000247
type: Species
is: HMDB00039
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
name: butyrate
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: CHEBI:17968

metaR DNDPt18m
is: SBO:0000185
reactant: MODEL1310110052#
name: dUDP transport via ADP antiport
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
is described by: ECO:0000269
product: MODEL1310110052#
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: false

metaM retinal cis 13 r
name: 13-cis-retinal
has only substance units: false
type: Species
constant: false
is: HMDB06220
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: CHEBI:45487

metaR r1961
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000185
reversible: false
reactant: MODEL1310110052#
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
modifier: MODEL1310110052#
type: Reaction

metaR FAOXC101C8m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

metaM datp c
has only substance units: false
is: C00131
boundary condition: false
type: Species
is: HMDB01532
name: dATP
initial amount: NaN
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
constant: false
initial concentration: 1.0
is: CHEBI:61404
is: SBO:0000247

metaM focytC m
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:16928
type: Species
boundary condition: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
is: SBO:0000247
name: Ferrocytochrome C
constant: false

metaR r0425
is version of: http://identifiers.org/ec-code/1.17.1.4
modifier: MODEL1310110052#
name: EC:1.1.1.42
kinetic law: MODEL1310110052#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:
reactant: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_85f80b94_a354_4192_b207_557e89d5614a
boundary condition: true
is encoded by: hsa:U37519
name: _U37519_1_e
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
constant: false

metaM glyb c
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00043
constant: false
type: Species
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
name: glycine betaine
is: CHEBI:17750
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110052#_054918c8_e0c1_4e04_b977_0d5b630c127e
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:3155
name: HMGCL
has only substance units: false
is: Q6IBC0
initial concentration: NaN
initial amount: NaN

metaR r2368
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110052#
reversible: true
is described by: ECO:0000000
product: MODEL1310110052#
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_b2f3ad64_b993_4768_b14c_3a6664fb945e
name: RBAK
is: SBO:0000252
is: Q9NYW8
has only substance units: false
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:57786

metaR ASNTHRNaEx
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110052#
name: L-threonine/L-asparagine Na-dependent exchange (Asn-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000185
reactant: MODEL1310110052#
type: Reaction

metaM c3dc c
is: HMDB02095
type: Species
initial amount: NaN
notes: FORMULA: C10H16NO6 CHARGE: -1
constant: false
name: malonyl carnitine
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM methf c
is: C00445
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57455
is: HMDB01354
has only substance units: false
type: Species
name: 5,10-Methenyltetrahydrofolate

metaM mescon m
is: SBO:0000247
type: Species
is: HMDB00749
constant: false
name: Mesaconate
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
boundary condition: false
is: CHEBI:36986
initial amount: NaN

metaR DCSPTN1t
is described by: ECO:0000000
kinetic law: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
name: fatty acid transport via diffusion
fast: false

metaM ksi deg21 l
is: SBO:0000247
constant: false
boundary condition: false
name: keratan sulfate I, degradation product 21
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00143
is: CHEBI:12936
initial concentration: 1.0
notes: FORMULA: C132H213N9O114S6 CHARGE: -6

metaR r0424
is: SBO:0000176
kinetic law: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is version of: http://identifiers.org/ec-code/1.17.1.4
modifier: MODEL1310110052#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
product: MODEL1310110052#
reversible: true
type: Reaction
is described by: ECO:0000000

metaM ocdcea c
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:0
is: SBO:0000247
is: C00712
notes: FORMULA: C18H33O2 CHARGE: -1
initial concentration: 1.0
is: HMDB00207
name: octadecenoate (n-C18:1)
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_10107b29_07a8_467f_91aa_d1598ddd36a8
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
name: DGKI
is: O75912
type: Species
is encoded by: hsa:9162
is: SBO:0000252
boundary condition: true

metaR PTDCAt
is described by: ECO:0000000
name: fatty acid transport via diffusion
reversible: true
reactant: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is: SBO:0000185
kinetic law: MODEL1310110052#

metaM fad m
type: Species
is: CHEBI:16238
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
name: Flavin adenine dinucleotide oxidized
initial amount: NaN
is: SBO:0000247
is: C00016
constant: false
initial concentration: 1.0
is: HMDB01248
boundary condition: false
has only substance units: false

metaR r0127
is version of: http://identifiers.org/ec-code/3.5.4.16
fast: false
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.38 Confidence Level: 0 AUTHORS: PMID:4311065,PMID:4894450 NOTES:
is: SBO:0000176
modifier: MODEL1310110052#
product: MODEL1310110052#
reversible: false
reactant: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#
name: L-Asparagine amidohydrolase Alanine and aspartate metabolism / Cyanoamino acid metabolism / Nitrogen metabolism EC:3.5.1.1 EC:3.5.1.38
type: Reaction

metaM alpro m
has only substance units: false
type: Species
name: S-Aminomethyldihydrolipoylprotein
boundary condition: false
initial amount: NaN
is: CHEBI:16882
constant: false
notes: FORMULA: CH6NS2X CHARGE: 1 EHMN_ABBREVIATION: C01242
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110052#_04d8c4d7_a3a8_4ea9_b610_d2f904af1362
is: SBO:0000252
is encoded by: hsa:56953
is: Q9NPB1
name: NT5M
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_c876f4d3_651c_416d_8eff_efe6f110a896
is: E9KL42
boundary condition: true
is: SBO:0000252
name: ACOT1
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:641371
initial concentration: NaN

metaR r2367
is described by: ECO:0000000
kinetic law: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reversible: true
fast: false

metaR TTDCAFATPc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaM srtn e
is: HMDB00259
constant: false
initial concentration: 1.0
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: CHEBI:350546
has only substance units: false
boundary condition: false
is: SBO:0000247
name: serotonin(1+)
type: Species
initial amount: NaN

metaM mercppyr c
name: 3-mercaptopyruvate
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:57678
initial amount: NaN
is: HMDB01368
constant: false
initial concentration: 1.0
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957

metaM h2o r
initial amount: NaN
boundary condition: false
is: HMDB02111
is: SBO:0000247
is: CHEBI:15377
name: H2O
constant: false
is: C00001
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

metaR r0354
is version of: http://identifiers.org/ec-code/6.2.1.3
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is: SBO:0000176
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
kinetic law: MODEL1310110052#
fast: false
reversible: false
modifier: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110052#

metaM glyb e
type: Species
name: glycine betaine
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
has only substance units: false
is: CHEBI:17750
is: HMDB00043
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

metaR C4CRNCPT2
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of butyryl carnitine in the mitochondrial matrix for final hydrolysis
type: Reaction

metaM lald L c
is: HMDB03052
type: Species
name: (S)-lactaldehyde
is: CHEBI:18041
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
initial amount: NaN

metaM ocde9ecoa x
initial concentration: 1.0
type: Species
name: 9-octadecenoylcoa
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280355

http://identifiers.org/biomodels.db/MODEL1310110052#_11eb5c2a_20e8_4d5a_a9f4_1856f6f56806
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: SLC25A12
is: O75746
constant: false
is encoded by: hsa:8604
boundary condition: true
initial concentration: NaN

metaM 6dhf e
initial amount: NaN
name: hexaglutamyl folate (DHF)
is: HMDB06563
is: SBO:0000247
type: Species
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0

metaR r0013
reversible: false
reactant: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
name: beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.52 Confidence Level: 0 AUTHORS: PMID:10481922,PMID:2423070,PMID:6219664,PMID:758959 NOTES:
modifier: MODEL1310110052#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
kinetic law: MODEL1310110052#

metaR ABTti
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reactant: MODEL1310110052#
reversible: false
name: L-arabinitol transport via passive diffusion
product: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_2dda4fa4_4c1f_4d09_8210_a839f54bd454
is encoded by: hsa:7001
type: Species
has only substance units: false
boundary condition: true
constant: false
name: PRDX2
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR FAOXC2252053m
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
name: Beta oxidation of long chain fatty acid
product: MODEL1310110052#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110052#
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaM thcholstoic c
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:18402
constant: false
has only substance units: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: HMDB03873
initial amount: NaN
boundary condition: false

metaR LNLNCGt
kinetic law: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
product: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110052#_049aaf49_9ebc_4dd0_b2d0_4c8f2c2869ef
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: O95167
name: NDUFA3
type: Species
is encoded by: hsa:4696
initial amount: NaN

metaR r1964
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110052#
name: Y+LAT2 Utilized transport
fast: false
is: SBO:0000185
modifier: MODEL1310110052#
type: Reaction
reversible: false

metaR M7MASNBterg
is: SBO:0000185
reactant: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000000
reversible: false
name: m7masnB transport from endoplasmic reticulum to Golgi apparatus
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction

metaM crn e
is: C00318
name: L-Carnitine
boundary condition: false
type: Species
constant: false
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: HMDB00062
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_007043e0_77d8_4b7f_be7a_8d797e043c37
is encoded by: hsa:AI915649
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
name: _AI915649_1_c
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_476fd90d_ebeb_4c0c_a530_19d210d54df1
is: Q16698
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
name: DECR1
is encoded by: hsa:1666
type: Species
constant: false

metaM g1p c
is: HMDB01586
is: CHEBI:58601
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
boundary condition: false
is: C00103
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
name: D-Glucose 1-phosphate
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_c5d320c3_994a_4869_a6d8_7c5f30310c86
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: O00764
is encoded by: hsa:8566
is: SBO:0000252
constant: false
boundary condition: true
name: PDXK

metaR C161OHc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecenoylcarnitine
type: Reaction

metaR r0426
reactant: MODEL1310110052#
product: MODEL1310110052#
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.34
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
is: SBO:0000176

metaR PAPtg
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: adenosine 3',5'-bisphosphate Golgi transport
type: Reaction
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110052#_3e930030_502b_45db_af5a_27f75ae52a2f
has only substance units: false
name: PNP
is: P00491
type: Species
constant: false
boundary condition: true
is encoded by: hsa:4860
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM val L m
name: L-valine
initial concentration: 1.0
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:16414
is: SBO:0000247
has only substance units: false
is: HMDB00883

metaR r2369
product: MODEL1310110052#
type: Reaction
name: Organic anion transporter 5 Utilized transport
fast: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
reactant: MODEL1310110052#
is: SBO:0000185
is described by: ECO:0000000

metaM srtn c
constant: false
is: CHEBI:350546
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00259
has only substance units: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
name: serotonin(1+)
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_9f8f22e3_891d_46a8_8a3c_b016e061fa21
boundary condition: true
has only substance units: false
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:26
is: SBO:0000252
name: ABP1
is: P19801
initial concentration: NaN

metaR ORNt4m
fast: false
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
name: ornithine mitochondrial transport exchange with citruline
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
is: SBO:0000185
type: Reaction
product: MODEL1310110052#
modifier: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_406ff58d_273d_4562_bcfd_50537f2149f8
boundary condition: true
is: SBO:0000252
is: Q8NFM4
has only substance units: false
is encoded by: hsa:196883
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
name: ADCY4

http://identifiers.org/biomodels.db/MODEL1310110052#_535cb3c2_61d4_4417_8547_28653f978b18
name: OGDH
is encoded by: hsa:4967
type: Species
constant: false
is: SBO:0000252
is: Q02218
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true

metaR GALSIDEtl
reversible: true
reactant: MODEL1310110052#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110052#
fast: false
type: Reaction
name: galactocerebroside intracellular transport
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ

metaM acgam l
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
name: N-acetyl-D-glucosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: HMDB00215
type: Species
is: CHEBI:17411

metaM f6p c
boundary condition: false
is: HMDB00124
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/3385
is: C00085
is: CHEBI:57579
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: D-Fructose 6-phosphate
constant: false

metaM 34hpl m
is: HMDB00755
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8,10-11H,5H2,(H,12,13)/p-1
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
name: 3-(4-hydroxyphenyl)lactate
constant: false
type: Species
is: SBO:0000247
is: CHEBI:36659

metaR r2098
product: MODEL1310110052#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110052#
is described by: ECO:0000000
modifier: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#

metaR DPCOAtl
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110052#
name: dephospho-CoA transport from lysosome via diffusion
fast: false
reactant: MODEL1310110052#
reversible: true
product: MODEL1310110052#

metaR DOPABMO
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (26002.1) or (1621.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.17.1 Confidence Level: 4 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.14.17.1
name: dopamine beta-monooxygenase
reactant: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110052#_b81c8198_53ad_47e8_aad2_2075c91fa68e
initial amount: NaN
has only substance units: false
name: HSD17B10
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:3028
initial concentration: NaN
is: Q99714

metaR EX progly LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for prolyl-glycine
type: Reaction

metaR CYSSERNaEx
modifier: MODEL1310110052#
type: Reaction
reversible: false
name: L-serine/L-cysteine Na-dependent exchange (Cys-L in)
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110052#
is: SBO:0000185
product: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
is described by: ECO:0000269

metaR XOL27OHtm
reactant: MODEL1310110052#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
name: 27 hydroxy cholesterol transport
product: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: true
fast: false

metaR CHSTEROLtrc
product: MODEL1310110052#
type: Reaction
reversible: true
is: SBO:0000185
name: transport of cholesterol into the cytosol
kinetic law: MODEL1310110052#
is described by: ECO:0000134
reactant: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.

http://identifiers.org/biomodels.db/MODEL1310110052#_63a38d7a_ba01_43d4_9cde_48c657a23034
initial concentration: NaN
name: PC
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5091
initial amount: NaN
type: Species
has only substance units: false

metaR N2M2NMASNtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: n2m2nmasn transport, extracellular to lysosome
fast: false
kinetic law: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
reactant: MODEL1310110052#
reversible: false
is described by: ECO:0000000
is: SBO:0000185

metaM crn m
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:16347
type: Species
is: C00318
is: HMDB00062
initial amount: NaN
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
name: L-Carnitine
boundary condition: false
is: SBO:0000247

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_d3a6fed9_944a_410b_a285_337fc15b46c7
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q96Q11
name: TRNT1
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:51095

metaM 13dampp c
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00002
is: CHEBI:57484
initial amount: NaN
name: trimethylenediaminium
type: Species

metaR FATP9t
product: MODEL1310110052#
name: fatty acid electroneutral transport
type: Reaction
is: SBO:0000185
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is version of: http://identifiers.org/ec-code/6.2.1.7
reactant: MODEL1310110052#
fast: false

metaR FACOAL246 1
kinetic law: MODEL1310110052#
type: Reaction
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
fast: false
product: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true

metaR r0202
is: SBO:0000176
kinetic law: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
reactant: MODEL1310110052#
reversible: true
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
fast: false
type: Reaction

metaR r2099
modifier: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110052#

metaM h2o n
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
type: Species
constant: false
is: HMDB02111
is: CHEBI:15377
name: water

metaR C50CPT1
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of isovalerylcarnitine
type: Reaction

metaR GALASE3ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
is described by: ECO:0000000
product: MODEL1310110052#
reactant: MODEL1310110052#
reversible: false
name: beta-galactosidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR C101CPT1
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decenoylcarnitine
type: Reaction

metaM pail35p hs c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
is: CHEBI:57923
has only substance units: false
type: Species
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
boundary condition: false
constant: false

metaM phyt c
boundary condition: false
has only substance units: false
is: HMDB00801
initial amount: NaN
is: CHEBI:37257
name: phytanate
type: Species
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
constant: false
is: SBO:0000247
initial concentration: 1.0

metaM spmd c
initial concentration: 1.0
is: CHEBI:57834
name: Spermidine
constant: false
initial amount: NaN
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: SBO:0000247
is: HMDB01257
is: C00315
has only substance units: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_b446991e_684e_41f2_a8fe_5a3040a30c5a
is encoded by: hsa:4597
is: SBO:0000252
has only substance units: false
boundary condition: true
is: P53602
initial concentration: NaN
name: MVD
constant: false
type: Species
initial amount: NaN

metaM ddece1crn e
initial concentration: 1.0
constant: false
is: HMDB02250
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C19H35NO4 CHARGE: 0
boundary condition: false
name: dodecenoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110052#_fc8e8b79_c280_4d5c_91c9_711866bf1aae
initial concentration: NaN
initial amount: NaN
constant: false
name: GPX6
boundary condition: true
is encoded by: hsa:257202
is: P59796
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_634f7989_4226_43c7_8703_3fd42ea58dcc
initial concentration: NaN
type: Species
initial amount: NaN
is: P00326
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:126
name: ADH1C
is: SBO:0000252

metaR RDH3a
name: retinol dehydrogenase (11-cis,NADPH)
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.105
is described by: ECO:0000269
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.1.300
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
reactant: MODEL1310110052#
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#

metaR AG13T2g
type: Reaction
fast: false
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110052#

metaR r2096
product: MODEL1310110052#
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110052#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110052#

metaR NACHEXA10ly
type: Reaction
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
product: MODEL1310110052#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
is described by: ECO:0000000

metaM man1p c
type: Species
is: HMDB06330
initial concentration: 1.0
initial amount: NaN
name: D-Mannose 1-phosphate
boundary condition: false
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
is: SBO:0000247
is: CHEBI:35374
has only substance units: false

metaM h2o m
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
is: SBO:0000247
name: H2O
is: C00001
initial amount: NaN
is: CHEBI:15377
is: HMDB02111
type: Species

metaR FAOXC183806m
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110052#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
fast: false
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#

metaM 3htdcoa c
type: Species
is: HMDB02014
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: (S)-3-Hydroxytetradecanoyl-CoA

metaM pcrn c
has only substance units: false
boundary condition: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
name: propionyl-carnitine
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/107738
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00824

metaR LNLNCGCRNt
reactant: MODEL1310110052#
fast: false
product: MODEL1310110052#
is described by: ECO:0000269
name: transport into the mitochondria (carnitine)
type: Reaction
modifier: MODEL1310110052#
is: SBO:0000185
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false

metaR GALt4
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
name: galactose transport via sodium symport
is described by: ECO:0000269
reversible: true
is: SBO:0000185
reactant: MODEL1310110052#
fast: false
type: Reaction
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110052#_d1bddebb_087d_408e_a61b_8c6881cf8769
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9926
name: LPGAT1
is: Q92604
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

metaR DM anth
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_68902f0a_82fe_423b_b0a1_2bdf5c601d0d
is: SBO:0000252
is encoded by: hsa:1374
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q8WZ48
name: CPT1A
type: Species
initial amount: NaN

metaR 4HGLSDm
reversible: true
is: SBO:0000176
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.5.1.12
reactant: MODEL1310110052#
type: Reaction
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
modifier: MODEL1310110052#
fast: false
is described by: ECO:0000212

metaM hexdectecoa m
initial concentration: 1.0
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: HMDB02288
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: 2,4,7,10-hexadecatetraenoylcoa
constant: false

metaM h2o l
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:15377
is: HMDB02111
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
name: water

http://identifiers.org/biomodels.db/MODEL1310110052#_a656af7d_0dc0_4e6d_b3da_890725fe6514
is: P14555
initial amount: NaN
is: SBO:0000252
name: PLA2G2A
boundary condition: true
constant: false
is encoded by: hsa:5320
initial concentration: NaN
has only substance units: false
type: Species

metaM core4 g
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:16478
notes: FORMULA: C24H40N3O15X CHARGE: 0
name: Core 4
initial amount: NaN
constant: false

metaR r2097
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110052#
fast: false
type: Reaction
kinetic law: MODEL1310110052#
reversible: true
modifier: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000000

metaR THRALANaEx
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110052#
is described by: ECO:0000269
kinetic law: MODEL1310110052#
type: Reaction
reversible: false
modifier: MODEL1310110052#
fast: false
name: L-alanine/L-threonine Na-dependent exchange (Thr-L in)
product: MODEL1310110052#
is: SBO:0000185

metaR r0129
type: Reaction
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000176
fast: false
reactant: MODEL1310110052#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
reversible: true
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.40

http://identifiers.org/biomodels.db/MODEL1310110052#_1c88d341_dd7b_49b6_a8a2_f63965d33a30
is: P16066
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4881
constant: false
name: NPR1

metaR DCSPTN1CRNt
type: Reaction
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110052#
reversible: false
is: SBO:0000185
name: transport into the mitochondria (carnitine)

metaR RE2069C
product: MODEL1310110052#
name: RE2069
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false

metaM phyt e
is: HMDB00801
boundary condition: false
initial amount: NaN
is: CHEBI:37257
has only substance units: false
type: Species
name: phytanate
constant: false
is: SBO:0000247
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110052#_58d42d30_cc12_4133_a37f_d88bd7344869
is encoded by: hsa:AA203143
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
name: _AA203143_1_c
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_7be672bf_bfcd_4125_8efd_929b4083f533
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:27124
is: Q15735
initial concentration: NaN
boundary condition: true
constant: false
name: INPP5J
has only substance units: false

metaM 5aop m
constant: false
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:17549
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: HMDB01149
boundary condition: false
name: 5-Amino-4-oxopentanoate
is: C00430

metaR SPODM
is: SBO:0000176
reactant: MODEL1310110052#
fast: false
type: Reaction
is described by: ECO:0000269
name: superoxide dismutase
product: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: false
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.15.1.1

metaM coucoa m
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: 4-coumaroyl-CoA(4-)
is: C00223
notes: FORMULA: C30H38N7O18P3S1 CHARGE: -4 INCHI: InChI=1S/C30H42N7O18P3S/c1-30(2,25(42)28(43)33-10-9-20(39)32-11-12-59-21(40)8-5-17-3-6-18(38)7-4-17)14-52-58(49,50)55-57(47,48)51-13-19-24(54-56(44,45)46)23(41)29(53-19)37-16-36-22-26(31)34-15-35-27(22)37/h3-8,15-16,19,23-25,29,38,41-42H,9-14H2,1-2H3,(H,32,39)(H,33,43)(H,47,48)(H,49,50)(H2,31,34,35)(H2,44,45,46)/p-4/t19-,23-,24-,25+,29-/m1/s1
is: CHEBI:57355

metaR ALCD21 D
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.1
modifier: MODEL1310110052#
fast: false
is: SBO:0000176
name: alcohol dehydrogenase (D-1,2-propanediol)
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.99.24
reversible: false
type: Reaction
is described by: ECO:0000304
product: MODEL1310110052#
kinetic law: MODEL1310110052#

metaR PEPCKm
reactant: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
is version of: http://identifiers.org/ec-code/4.1.1.32
is: SBO:0000176
kinetic law: MODEL1310110052#
name: Phosphoenolpyruvate carboxykinase (GTP)
type: Reaction
reversible: false
modifier: MODEL1310110052#
fast: false
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_07deb75a_7aaf_4f0f_89e8_f93d17ef4f8f
constant: false
initial concentration: NaN
name: NT5C
is: SBO:0000252
is encoded by: hsa:30833
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is: Q8TCD5

metaM 3hexdtricoa m
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: HMDB02288
initial concentration: 1.0
type: Species
name: 3,7,10-hexadecatrienoylcoa
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: SBO:0000247

metaR OCDCEAtr
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reversible: true
type: Reaction
name: fatty acid transport via diffusion
reactant: MODEL1310110052#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110052#

metaM 34dhpac c
initial concentration: 1.0
is: CHEBI:27978
is: SBO:0000247
has only substance units: false
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043
constant: false
initial amount: NaN
type: Species
is: HMDB03791
name: 3,4-Dihydroxyphenylacetaldehyde
boundary condition: false

metaR FAOXC226C225m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaR r0384
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000176
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
is described by: ECO:0000000
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:

metaR FACOAL140i
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
kinetic law: MODEL1310110052#
name: fatty-acid--CoA ligase (tetradecanoate)
type: Reaction
is described by: ECO:0000269
fast: false
reversible: false
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110052#
is: SBO:0000176
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_0ae060b0_c8ed_4322_a172_c4ba3db1826a
initial concentration: NaN
name: COX5A
boundary condition: true
is: P20674
is: SBO:0000252
type: Species
is encoded by: hsa:9377
has only substance units: false
constant: false
initial amount: NaN

metaR ESTSULT
kinetic law: MODEL1310110052#
is described by: ECO:0000269
name: Estrogen sulfotransferase
reactant: MODEL1310110052#
reversible: false
type: Reaction
is: SBO:0000176
product: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.8.2.1
fast: false
notes: GENE_ASSOCIATION: (6783.1) or (6817.4) or (6817.1) or (6817.3) or (6817.2) or (6817.5) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.4 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:8185618 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.8.2.4

metaM utp c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00285
is: CHEBI:46398
name: UTP
is: C00075
initial amount: NaN
boundary condition: false
type: Species
constant: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075

metaM itp c
constant: false
type: Species
name: ITP(3-)
is: SBO:0000247
is: HMDB00189
initial concentration: 1.0
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
has only substance units: false
is: CHEBI:57614
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_33a529aa_6a0b_474b_b271_b2948959df22
is: Q92185
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:6489
is: SBO:0000252
name: ST8SIA1

metaM acgpail hs c
initial concentration: 1.0
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
has only substance units: false
is: CHEBI:57265
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_4319e7ff_fe32_4c80_b024_5ef8d65cc8f7
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: HADHA
is: E9KL44
is encoded by: hsa:3030
constant: false

metaR ARACHt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
fast: false
is: SBO:0000185
product: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#

metaR FAOXC2442246x
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110052#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110052#
name: Beta oxidation of long chain fatty acid
reversible: false
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c24:4,n-6 -> c22:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
kinetic law: MODEL1310110052#
is described by: ECO:0000269
product: MODEL1310110052#

metaM HC02214 e
is: SBO:0000247
name: prostaglandin-f1alpha
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: CHEBI:28852
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaM ametam c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137
is: HMDB00988
boundary condition: false
name: S-Adenosylmethioninamine
initial concentration: 1.0
is: C01137
type: Species
initial amount: NaN
constant: false
is: CHEBI:57443

http://identifiers.org/biomodels.db/MODEL1310110052#_f99b8c65_e7da_43c9_a7a5_b4846c460b01
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:23305
has only substance units: false
name: ACSL6
type: Species
initial amount: NaN
is: B2RB13

http://identifiers.org/biomodels.db/MODEL1310110052#_f1c02a04_5695_4e01_bdc5_e4565c3c927b
type: Species
initial concentration: NaN
constant: false
name: ACOX1
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51
is: B4DK61
initial amount: NaN

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_d6a89650_6dd8_40db_878f_c8e69adff5a9
constant: false
initial amount: NaN
initial concentration: NaN
name: SCD
is: O00767
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6319

http://identifiers.org/biomodels.db/MODEL1310110052#_2e300883_10a2_4f3e_a419_ad9d9205da60
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6508
has only substance units: false
is: SBO:0000252
type: Species
name: SLC4A3

metaR G6PDH1rer
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
is version of: http://identifiers.org/ec-code/1.1.1.47
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
is: SBO:0000176
fast: false
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
reversible: true

metaM adp m
initial amount: NaN
is: CHEBI:456216
initial concentration: 1.0
is: SBO:0000247
is: C00008
boundary condition: false
has only substance units: false
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/3310
name: ADP
is: HMDB01341

http://identifiers.org/biomodels.db/MODEL1310110052#_8dc5553e_124f_45d2_870e_64b73f5b0d8a
is: B7Z5T8
type: Species
boundary condition: true
is encoded by: hsa:1375
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: CPT1B

metaR RE3627M
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110052#
fast: false
reversible: true
reactant: MODEL1310110052#
product: MODEL1310110052#
modifier: MODEL1310110052#
name: RE3627
is described by: ECO:0000000
type: Reaction

metaM acald e
boundary condition: false
constant: false
is: CHEBI:15343
type: Species
initial amount: NaN
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial concentration: 1.0
is: HMDB00990
is: SBO:0000247
has only substance units: false
name: acetaldehyde

metaR r0400
reactant: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.4.4
fast: false
reversible: true
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2

metaR r0385
reactant: MODEL1310110052#
fast: false
reversible: false
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
kinetic law: MODEL1310110052#
is: SBO:0000176
product: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:

metaR EX tethex3 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosahexaenoic acid, n-3 exchange
type: Reaction

metaR ACGALK
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
reversible: false
name: N-acetylgalactosamine kinase
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110052#

metaM ksii core2 deg3 l
is: CHEBI:12936
type: Species
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00143
is: SBO:0000247
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
name: keratan sulfate II (core 2-linked), degradation product 3
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110052#_e4f5376f_a355_4aee_91a0_5cdb6694c63e
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
name: HK1
is: SBO:0000252
constant: false
is: B3KXY9
initial concentration: NaN
is encoded by: hsa:3098

metaM hLkynr c
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
name: 3-hydroxy-L-kynurenine
is: HMDB11631
has only substance units: false
is: CHEBI:17380
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR sink tetdece1coa LPAREN c RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDECE1COASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_5147af9f_c72f_401c_ba24_0d7549788bce
initial amount: NaN
type: Species
is encoded by: hsa:3614
name: IMPDH1
is: C9JV30
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_7670adb9_edd6_4c4e_992f_7844843ac1c9
is: SBO:0000252
name: _AW299740_1_m
has only substance units: false
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AW299740
initial amount: NaN

metaM c81coa c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
is: HMDB03949
is: C05276
initial amount: NaN
name: octenoylcoa
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_4ea14caf_e30f_472f_bba1_570a56fe8618
name: SCP2
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:6342
is: C9JC79

http://identifiers.org/biomodels.db/MODEL1310110052#_242a4c06_b43f_43c8_a329_c0fe96dd19c0
name: LDHD
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:197257
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false

metaM itp e
is: HMDB00189
constant: false
is: CHEBI:57614
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial amount: NaN
name: ITP(3-)

metaM utp e
constant: false
boundary condition: false
type: Species
name: UTP(4-)
initial concentration: 1.0
is: CHEBI:46398
is: SBO:0000247
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
initial amount: NaN
has only substance units: false
is: HMDB00285

metaM HC02214 c
type: Species
name: prostaglandin-f1alpha
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: SBO:0000247
is: CHEBI:28852
has only substance units: false
initial amount: NaN
constant: false

metaM nicrnt c
is: C01185
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
is: SBO:0000247
name: Nicotinate D-ribonucleotide
is: HMDB01132
is: CHEBI:57502

metaM lys L c
initial concentration: 1.0
is: CHEBI:32551
boundary condition: false
constant: false
type: Species
initial amount: NaN
has only substance units: false
name: L-lysinium(1+)
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: SBO:0000247
is: HMDB00182

metaM ksii core2 deg9 l
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:12936
name: keratan sulfate II (core 2-linked), degradation product 9
constant: false
is: HMDB00143
initial concentration: 1.0
notes: FORMULA: C30H50N3O20X CHARGE: 0

metaR DOPASFt
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
name: Dopamine 3-0-sulfate transport (diffusion)
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_53f4d0d2_5420_4f83_8404_4e1042406445
is encoded by: hsa:8802
is: SBO:0000297
type: Species
initial amount: NaN
has part: Q96I99
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8801
constant: false
name: SUCLG2:SUCLG1
has part: P53597
boundary condition: true

metaM CE5132 c
type: Species
is: CHEBI:57923
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
constant: false
is: SBO:0000247
boundary condition: false

metaR TKT1
name: transketolase
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.2.1.1
product: MODEL1310110052#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is described by: ECO:0000000
reactant: MODEL1310110052#
type: Reaction
reversible: true
modifier: MODEL1310110052#

metaR EX malcoa LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: malonyl-CoA(4-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_2e0247f0_dcd4_431d_844f_5a84d72521c4
name: INPP5E
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:56623
boundary condition: true
initial amount: NaN
is: Q9NRR6
has only substance units: false
constant: false

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

metaM adp n
type: Species
constant: false
is: HMDB01341
is: SBO:0000247
has only substance units: false
name: ADP(3-)
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial amount: NaN
boundary condition: false
is: CHEBI:456216

metaM caro c
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:17579
constant: false
is: HMDB00561
name: beta-carotene
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM dgsn c
is: C00330
name: Deoxyguanosine
is: HMDB00085
is: CHEBI:17172
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
constant: false

metaR ACONTm
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is described by: ECO:0000134
name: Aconitate hydratase
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/4.2.1.3
reactant: MODEL1310110052#
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110052#_9ddc5a31_9004_4064_be5a_bf8ab2e0e781
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
name: SGPL1
initial concentration: NaN
is: O95470
is encoded by: hsa:8879
boundary condition: true

metaR H2O2tn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
is: SBO:0000185
name: hydrogen peroxide nuclear transport
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110052#
reversible: true

metaR FACOAL80i
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
product: MODEL1310110052#
name: fatty-acid--CoA ligase (octanoate)
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110052#
is: SBO:0000176
is described by: ECO:0000269

metaR r0407
is version of: http://identifiers.org/ec-code/1.4.3.5
fast: false
kinetic law: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110052#
type: Reaction
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
reactant: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
reversible: true

metaR TKT2
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.2.1.1
product: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110052#
name: transketolase
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is: SBO:0000176

metaR LTD4DP
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
is described by: ECO:0000000
product: MODEL1310110052#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
reversible: true
name: Leukotriene D4 dipeptidase

metaM ficytC m
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
initial concentration: 1.0
constant: false
name: Ferricytochrome c
is: CHEBI:15991
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false

metaR r0388
kinetic law: MODEL1310110052#
reversible: true
product: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
is described by: ECO:0000000
name: Pyridoxamine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.4.3.5
type: Reaction

metaM eitetcoa m
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
constant: false
name: 5,8,11,14-eicosatetraenoylcoa
initial concentration: 1.0
boundary condition: false

metaR H2O2tm
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
kinetic law: MODEL1310110052#
is described by: ECO:0000000
name: hydrogen peroxide mitochondrial transport

metaR UMPK7
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
name: UMP kinase (dGTP)
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110052#

metaR r0517
kinetic law: MODEL1310110052#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
product: MODEL1310110052#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_0133f39e_34f4_415d_93c5_520045bad536
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:2222
name: FDFT1
initial concentration: NaN
constant: false
is: P37268
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_f82a88e1_b2f0_4374_832a_54610739645b
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: HADH
is: Q16836
constant: false
is encoded by: hsa:3033

metaR DMANTIPYRINEte
is: SBO:0000185
reactant: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
name: xenobiotic transport
reversible: true
product: MODEL1310110052#
is described by: ECO:0000000

metaR RE1845C
type: Reaction
is: SBO:0000176
product: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
name: RE1845

metaM cs b deg3 l
is: CHEBI:21338
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 3
initial concentration: 1.0
notes: FORMULA: C37H55NO38S2 CHARGE: -4
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
is: HMDB02704
constant: false

metaR EX antipyrene LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: antipyrene exchange
type: Reaction

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaM dgsn e
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:17172
boundary condition: false
is: HMDB00085
initial concentration: 1.0
name: Deoxyguanosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: C00330

metaR r2433
product: MODEL1310110052#
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
reversible: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaR sink decdicoa LPAREN c RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Sink for 2,6-dodecadienoylcoa(c)
type: Reaction

metaR G14T10g
modifier: MODEL1310110052#
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110052#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110052#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110052#

metaR UMPK6
kinetic law: MODEL1310110052#
is described by: ECO:0000269
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110052#
fast: false
reversible: true
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
type: Reaction
name: UMP kinase (dCTP)

metaR EX dmhptcrn LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2,6 dimethylheptanoyl carnitine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_696dff8e_34c1_4a1e_9387_1aa9f7849b6a
is encoded by: hsa:57127
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
type: Species
name: RHBG
is: Q9H310
initial concentration: NaN
is: SBO:0000252

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

metaR r1657
is described by: ECO:0000000
product: MODEL1310110052#
reversible: true
fast: false
reactant: MODEL1310110052#
is: SBO:0000185
modifier: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR FAOXC15C13m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C15-->C13)m
type: Reaction

metaM CE5119 m
is: CHEBI:57923
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
name: trans-3-cis-8-tetradecadienoyl-CoA
is: SBO:0000247

metaM adp c
has only substance units: false
is: http://identifiers.org/pubchem.compound/3310
initial concentration: 1.0
is: CHEBI:16761
name: ADP
initial amount: NaN
type: Species
constant: false
is: HMDB01341
boundary condition: false
is: SBO:0000247
is: C00008

metaR C2tcx
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of acetylcarnitine from peroxisomes to cytosol
type: Reaction

metaR DPMVDx
type: Reaction
name: diphosphomevalonate decarboxylase
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.1.33 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
is described by: ECO:0000134
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
is: SBO:0000176
product: MODEL1310110052#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.33
reactant: MODEL1310110052#

metaR 5MTAte
type: Reaction
fast: false
reactant: MODEL1310110052#
product: MODEL1310110052#
name: Transport of 5-S-methyl-5-thioadenosine
kinetic law: MODEL1310110052#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110052#_a299228b_2355_481c_8f3b_728be0f4cd1f
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: _AI373818_1_m
is encoded by: hsa:AI373818
type: Species
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_144f2adc_0e8b_40ce_bcdb_e9c5e9ad9dc6
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
name: _R51273_1_c
boundary condition: true
constant: false
is encoded by: hsa:R51273
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_7d0f5e9c_b80b_4a17_a356_667960afc74f
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
has part: Q8TEQ8
boundary condition: true
is encoded by: hsa:84720
name: PIGF:PIGO
constant: false
has part: Q07326
is encoded by: hsa:5281

metaR ALCD21 L
modifier: MODEL1310110052#
fast: false
is: SBO:0000176
name: alcohol dehydrogenase (L-1,2-propanediol)
product: MODEL1310110052#
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.99.24
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000304
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD

metaR FAOXC225C226m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

metaR C162ACBP
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxy trans7,10-hexadecadienoylcoa from mitochondria into cytosol
type: Reaction

metaR DNDPt10m
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dADP transport via dCDP antiport
is: SBO:0000185
modifier: MODEL1310110052#
reversible: false
is described by: ECO:0000269
fast: false
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_928cc7c4_1f55_45df_a966_352292daede1
constant: false
is encoded by: hsa:7359
name: _7359_1_c
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN

metaR r1656
fast: false
reactant: MODEL1310110052#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction

metaR LNSTLSr
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
is version of: http://identifiers.org/ec-code/5.4.99.7
type: Reaction
modifier: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110052#
name: lanosterol synthase
is described by: ECO:0000134
kinetic law: MODEL1310110052#

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR RE2814R
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110052#
name: RE2814
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction

metaM his L m
initial amount: NaN
constant: false
is: SBO:0000247
name: L-histidine
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: HMDB00177
is: CHEBI:15971
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110052#_abef98f0_0279_40fd_9f9d_6eea020c8af6
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:5288
is: SBO:0000252
constant: false
initial amount: NaN
name: PIK3C2G
is: O75747
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_63ac0042_d008_47a3_ab9c_3d2a41140d6f
is encoded by: hsa:85365
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
name: ALG2

metaM 34dhmald c
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
type: Species
boundary condition: false
initial amount: NaN
is: HMDB06242
name: 3,4-Dihydroxymandelaldehyde
is: http://identifiers.org/pubchem.compound/7903
is: C05577
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaR DDECCRNe
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of lauroyl carnitine into extra cellular space
type: Reaction

metaR r1078
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000000
fast: false
name: Vesicular transport
is: SBO:0000185
kinetic law: MODEL1310110052#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110052#_705cbaf2_4b07_47b2_9aa3_051682928112
initial amount: NaN
type: Species
is: Q8NEB9
initial concentration: NaN
is encoded by: hsa:5289
constant: false
name: PIK3C3
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR S6T9g
is: SBO:0000176
modifier: MODEL1310110052#
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110052#_de11fc70_2f94_47dd_aff7_2fb63d5a3622
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: SLC46A1
type: Species
is encoded by: hsa:113235
initial amount: NaN
is: Q96NT5

metaM adp e
is: CHEBI:456216
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
name: ADP(3-)
has only substance units: false
type: Species
constant: false
is: HMDB01341

metaR r1655
product: MODEL1310110052#
reversible: true
is described by: ECO:0000000
fast: false
modifier: MODEL1310110052#
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_6fa38584_c123_46ce_9a42_e12d30ca547d
is: A8K092
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
name: ATP5A1
constant: false
initial amount: NaN
is encoded by: hsa:498
has only substance units: false

metaR RETI2
is: SBO:0000176
reversible: true
type: Reaction
product: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
fast: false
name: retinol isomerase (9-cis)
reactant: MODEL1310110052#

metaR r0408
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.4.3.5
fast: false
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
reactant: MODEL1310110052#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_ee1f63f0_691b_4bd8_9ae3_8a85aabecfb9
type: Species
is: SBO:0000252
name: ADH7
is: P40394
has only substance units: false
constant: false
is encoded by: hsa:131
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR G14T21g
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_7de44ee2_b963_42a4_9f55_156a15ab329a
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:NOS2A
name: _NOS2A_1_c
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_642ce1c1_0572_4883_a4de_b0b228419e6c
initial amount: NaN
name: PDE5A
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:8654
is: SBO:0000252
constant: false
is: G5E9C5

http://identifiers.org/biomodels.db/MODEL1310110052#_a79b105b_3461_440f_872d_c10fdf580cfc
constant: false
is: Q6FGV9
is: SBO:0000252
type: Species
is encoded by: hsa:10654
name: PMVK
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM lys L e
is: CHEBI:32551
initial concentration: 1.0
is: SBO:0000247
name: L-lysinium(1+)
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00182
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047

http://identifiers.org/biomodels.db/MODEL1310110052#_a982f500_4b6c_4365_bfca_8fd7f17f9364
has only substance units: false
is encoded by: hsa:26279
initial concentration: NaN
name: PLA2G2D
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is: Q9UNK4
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_7cf89dfb_fcbf_4c33_b118_ad98b9f9025d
is encoded by: hsa:513
constant: false
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: ATP5D

metaM btcoa m
is: CHEBI:57371
is: HMDB01088
initial amount: NaN
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
name: Butanoyl-CoA
is: C00136
constant: false
initial concentration: 1.0

metaR r1654
type: Reaction
fast: false
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
modifier: MODEL1310110052#
product: MODEL1310110052#

metaR C40CPT1
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

metaM fn2m2masn g
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
has only substance units: false
is: CHEBI:32984
initial amount: NaN
type: Species

metaM mescoa m
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
initial amount: NaN
type: Species
is: CHEBI:27969
name: Mesaconyl-CoA
has only substance units: false
is: C06028
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false

metaR r0514
product: MODEL1310110052#
name: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
reactant: MODEL1310110052#
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:

metaR Asn X Ser Thrtr
is described by: ECO:0000269
name: Asn-X-Ser/Thr transport (from ER to lysosome)
kinetic law: MODEL1310110052#
fast: false
product: MODEL1310110052#
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
reactant: MODEL1310110052#

metaM CE2705 n
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial amount: NaN
name: quinonoid dihydrobiopterin
boundary condition: false
is: CHEBI:15374
type: Species
initial concentration: 1.0
is: HMDB02281
is: SBO:0000247
has only substance units: false
constant: false

metaR GLYt7 211 r
is described by: ECO:0000269
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110052#
reversible: true
name: glycine reversible transport via sodium and chloride symport (2:1:1)
fast: false
is: SBO:0000185
kinetic law: MODEL1310110052#
type: Reaction
product: MODEL1310110052#

metaM 3deccrn e
is: SBO:0000247
name: 3-hydroxydecanoylcarnitine
notes: FORMULA: C17H33NO5 CHARGE: 0
type: Species
is: HMDB02250
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaM caro e
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094
name: beta-carotene
is: HMDB00561
boundary condition: false
type: Species
is: SBO:0000247
constant: false
is: CHEBI:17579

metaM octdececrn m
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
is: HMDB06351
boundary condition: false
constant: false
notes: FORMULA: C25H47NO4 CHARGE: 0
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM hxcoa m
is: HMDB06522
name: Hexanoyl-CoA (n-C6:0CoA)
is: SBO:0000247
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
has only substance units: false

metaR RE0830N
fast: false
reactant: MODEL1310110052#
product: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.96
is: SBO:0000176
is described by: ECO:0000000
name: RE0830

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaM 3hpcoa m
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:58528
boundary condition: false
initial concentration: 1.0
name: 3-hydroxypropanoyl-CoA(4-)
type: Species
constant: false
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
is: HMDB06807

metaR NOt
reactant: MODEL1310110052#
name: NO transport (diffusion)
product: MODEL1310110052#
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
is described by: ECO:0000000
is: SBO:0000185

metaM pyr c
notes: FORMULA: C3H3O3 CHARGE: -1
is: SBO:0000247
is: CHEBI:15361
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: HMDB00243
is: C00022
initial amount: NaN
name: pyruvate
boundary condition: false
is: http://identifiers.org/pubchem.compound/3324

metaM HC02180 c
initial amount: NaN
constant: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:28728
name: thromboxane-b2
type: Species
initial concentration: 1.0

metaM acald c
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:15343
name: acetaldehyde
has only substance units: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: HMDB00990
constant: false

metaR r1653
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110052#_405ddeae_abcd_409d_a6e5_3c931a652b44
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4832
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: NME3
is: Q13232

metaR NCKt
kinetic law: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
name: Na+/Ca2+-K+ exchange
is described by: ECO:0000269
reactant: MODEL1310110052#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
fast: false
modifier: MODEL1310110052#

metaR 3HLYTCL
is described by: ECO:0000269
fast: false
reversible: false
reactant: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: NOTES:SAB
type: Reaction
name: 3-Hydroxy-L-tyrosine carboxy-lyase
is version of: http://identifiers.org/ec-code/4.1.1.28
is: SBO:0000176
modifier: MODEL1310110052#

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaR ACCOAgt
name: acetyl-coa transport
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
modifier: MODEL1310110052#

metaM g1m8masn r
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C76H127N2O60X CHARGE: 0
is: C05875
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR HOCTDECCRNe
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyoctadecanoyl carnitine into extra cellular space
type: Reaction

metaM 3hbcoa m
is: HMDB01166
constant: false
initial amount: NaN
name: (S)-3-hydroxybutanoyl-CoA(4-)
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
is: CHEBI:57316
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species

metaR FALDH
reactant: MODEL1310110052#
modifier: MODEL1310110052#
reversible: true
kinetic law: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.1
is: SBO:0000176
fast: false
is described by: ECO:0000269
product: MODEL1310110052#
name: formaldehyde dehydrogenase

metaR r0512
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
product: MODEL1310110052#
modifier: MODEL1310110052#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3

metaR r1652
modifier: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110052#
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110052#_c594506e_593e_47e0_9a43_c190dc5c49fb
is: SBO:0000252
constant: false
type: Species
is: O15254
boundary condition: true
initial amount: NaN
name: ACOX3
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8310

http://identifiers.org/biomodels.db/MODEL1310110052#_b8e6264f_1430_4a0b_99e1_c64e0635167c
type: Species
has only substance units: false
constant: false
is: O14734
boundary condition: true
initial amount: NaN
name: ACOT8
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10005

metaM 3deccrn c
name: 3-hydroxydecanoylcarnitine
constant: false
initial amount: NaN
notes: FORMULA: C17H33NO5 CHARGE: 0
boundary condition: false
type: Species
is: HMDB00651
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR FAOXC8C6x
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_ca59fdaf_0aec_479e_aca2_491c8a196780
is: B4DYG5
has only substance units: false
type: Species
is encoded by: hsa:5297
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
name: PI4KA

http://identifiers.org/biomodels.db/MODEL1310110052#_fd08e5e5_aedb_4a79_8bac_386d933d5495
constant: false
initial concentration: NaN
boundary condition: true
name: NME1
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:4830
initial amount: NaN
is: P15531

http://identifiers.org/biomodels.db/MODEL1310110052#_4bac3957_e7ad_40dc_8d81_180d7bf180f3
constant: false
initial concentration: NaN
is: P49753
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: ACOT2
type: Species
has only substance units: false
is encoded by: hsa:10965

metaR FATP6t
fast: false
kinetic law: MODEL1310110052#
is: SBO:0000185
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110052#
is described by: ECO:0000269
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is version of: http://identifiers.org/ec-code/6.2.1.7
modifier: MODEL1310110052#
name: fatty acid electroneutral transport

metaR DOLASNT Ler
is version of: http://identifiers.org/ec-code/2.4.1.119
reversible: false
fast: false
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (liver)
is described by: ECO:0000000
modifier: MODEL1310110052#
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110052#_ddf2beb8_57c0_4824_a384_11a602354523
type: Species
boundary condition: true
is encoded by: hsa:51557
constant: false
is: Q5TDP6
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: LGSN

http://identifiers.org/biomodels.db/MODEL1310110052#_dda7307a_b983_430f_8de1_9b18d5aad6fe
type: Species
is: Q8N0W3
has only substance units: false
name: FUK
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:197258
boundary condition: true
constant: false

metaR r0276
is version of: http://identifiers.org/ec-code/1.1.1.21
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.1.2
fast: false
is: SBO:0000176
reactant: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
reversible: true

metaM dctp n
is: CHEBI:16311
type: Species
initial amount: NaN
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: C00458
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00998
constant: false
name: dCTP

metaM ach n
boundary condition: false
name: acetylcholine
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
has only substance units: false
is: HMDB00895
is: SBO:0000247
constant: false
type: Species
is: CHEBI:15355
initial amount: NaN
initial concentration: 1.0

metaR r1651
is: SBO:0000185
fast: false
kinetic law: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110052#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110052#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_d02b3738_0627_48f2_8cb4_7da0a21d4272
is: SBO:0000252
is: A7E2E5
initial concentration: NaN
name: PDE3B
boundary condition: true
is encoded by: hsa:5140
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaM 7thf e
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB06559
notes: FORMULA: C49H57N13O24 CHARGE: -8
has only substance units: false
boundary condition: false
name: heptaglutamyl folate (THF)
initial concentration: 1.0

metaR C204CPT2
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
product: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110052#
modifier: MODEL1310110052#
name: arachidonic acid transport into the mitochondria
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
fast: false
kinetic law: MODEL1310110052#

metaR GCC2cm
type: Reaction
name: glycine-cleavage complex (lipoamide), mitochondrial
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.4.2
product: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.8.1.4
reactant: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.1.2.10

metaR r1650
kinetic law: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
modifier: MODEL1310110052#

metaR S6T13g
kinetic law: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
modifier: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176

metaR TALA
is version of: http://identifiers.org/ec-code/2.2.1.2
modifier: MODEL1310110052#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110052#
fast: false
product: MODEL1310110052#
name: transaldolase
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_52bf02df_101a_4131_8dbc_db386d911dbf
initial amount: NaN
is: P27144
constant: false
is encoded by: hsa:205
boundary condition: true
has only substance units: false
initial concentration: NaN
name: AK4
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_2b8b4cf2_7327_4cce_b4ef_13de701f3c25
initial concentration: NaN
is: P00441
is encoded by: hsa:6647
is: SBO:0000252
has only substance units: false
boundary condition: true
name: SOD1
constant: false
initial amount: NaN
type: Species

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_947f1970_5f78_4484_9a9a_980631a02d32
constant: false
is encoded by: hsa:517
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000297
has only substance units: false
has part: Q06055

metaM hxcoa x
is: SBO:0000247
initial amount: NaN
name: Hexanoyl-CoA (n-C6:0CoA)
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
is: HMDB00705
has only substance units: false
constant: false
type: Species
boundary condition: false
initial concentration: 1.0

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaM octdececrn c
initial concentration: 1.0
is: HMDB06351
initial amount: NaN
type: Species
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
constant: false
has only substance units: false
notes: FORMULA: C25H47NO4 CHARGE: 0
boundary condition: false
is: SBO:0000247

metaR PI4PLC
reversible: false
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.4.11
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
modifier: MODEL1310110052#
reactant: MODEL1310110052#
name: phosphatidylinositol 4-phosphate phospholipase C
product: MODEL1310110052#

metaR PIt8
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
kinetic law: MODEL1310110052#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110052#
fast: false
product: MODEL1310110052#
name: phosphate transport in/out via Na+ symporter
modifier: MODEL1310110052#
reversible: true
is described by: ECO:0000006

http://identifiers.org/biomodels.db/MODEL1310110052#_ac67e4de_1752_4b6b_b007_56e80d916362
type: Species
name: SLC6A2
has only substance units: false
is encoded by: hsa:6530
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: Q96KH8
is: SBO:0000252

metaM btcoa c
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
is: HMDB01088
is: C00136
is: SBO:0000247
is: CHEBI:57371
has only substance units: false
name: Butanoyl-CoA
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_f0543f58_de24_40ab_9f1e_32dd73e094c6
type: Species
name: ALDH5A1
is: Q546H9
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7915
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_1d8a3ad3_8fe3_465a_965e_acb1277cd8cf
name: _AI684467_1_m
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:AI684467
type: Species
is: SBO:0000252
initial concentration: NaN

metaM his L c
is: CHEBI:15971
constant: false
initial amount: NaN
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
has only substance units: false
name: L-histidine
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00177

metaM dag hs r
constant: false
is: CHEBI:18035
type: Species
name: diglyceride
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
is: SBO:0000247
has only substance units: false

metaM andrstrn r
name: androsterone
initial amount: NaN
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
constant: false
is: CHEBI:16032
boundary condition: false
is: HMDB00031
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false

metaM Asn X Ser Thr l
is: C01342
notes: FORMULA: XH CHARGE: 0
has only substance units: false
initial amount: NaN
is: CHEBI:28938
is: SBO:0000247
constant: false
boundary condition: false
name: protein-linked asparagine residue (N-glycosylation site)
is: HMDB00051
type: Species
initial concentration: 1.0

metaR NACHEX22ly
fast: false
type: Reaction
modifier: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110052#
kinetic law: MODEL1310110052#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110052#_d4599072_b1dc_4dcf_bba3_837e090fe09d
has only substance units: false
name: _AI653169_1_c
is encoded by: hsa:AI653169
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_9bf7a5fb_f94d_4ff4_bceb_e139e75f99c7
is encoded by: hsa:6392
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: SDHD
constant: false
is: O14521
boundary condition: true
initial concentration: NaN

metaR PGK
modifier: MODEL1310110052#
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.2.3
fast: false
is: SBO:0000176
type: Reaction
name: phosphoglycerate kinase
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: true
is described by: ECO:0000134

metaM HC00900 c
constant: false
is: SBO:0000247
name: Methylmalonate
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
initial amount: NaN
is: CHEBI:30860
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_cbf15371_55b6_4767_9a6c_48b13472b81e
boundary condition: true
initial concentration: NaN
constant: false
is: B3KT86
name: ADCY3
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:109
has only substance units: false

metaR FAOXC22C20x
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22-->C20)x
type: Reaction

metaR C161CRNt
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction
name: C161 transport into the mitochondria
reversible: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
modifier: MODEL1310110052#
fast: false
product: MODEL1310110052#

metaM oaa c
constant: false
type: Species
name: Oxaloacetate
is: C00036
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00223
notes: FORMULA: C4H2O5 CHARGE: -2
is: SBO:0000247
is: CHEBI:3338
boundary condition: false

metaM aicar e
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C9H13N4O8P CHARGE: -2
has only substance units: false
is: HMDB01517
type: Species
is: CHEBI:58475
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
initial amount: NaN
is: C04677

metaR RE1525M
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110052#
type: Reaction
modifier: MODEL1310110052#
fast: false
reversible: true
name: RE1525
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_4de96f78_fe12_46a5_aafd_fbdcbe676c6a
has only substance units: false
type: Species
is: SBO:0000252
name: SLC25A2
initial amount: NaN
is encoded by: hsa:83884
boundary condition: true
constant: false
is: Q9BXI2
initial concentration: NaN

metaM dgchol c
name: glycochenodeoxycholate
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial amount: NaN
is: CHEBI:36252
constant: false
is: HMDB00637

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaM lys L m
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: HMDB00182
name: L-lysinium(1+)
is: CHEBI:32551
initial concentration: 1.0

metaR 3MOPt2im
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
reactant: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#
is: SBO:0000185
type: Reaction
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
reversible: false

metaR PIt7
is described by: ECO:0000269
reversible: true
is: SBO:0000185
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
fast: false
type: Reaction
product: MODEL1310110052#
name: phosphate transport in/out via three Na+ symporter
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_4f7b5de7_2cb0_412f_9c2f_6f75275e299f
name: _AA977580_1_c
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:AA977580
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_27f1ff7d_e57f_4545_8001_423350c24386
is encoded by: hsa:23556
initial concentration: NaN
constant: false
name: PIGN
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_86728d68_027a_49c2_8a51_868861753588
has only substance units: false
initial amount: NaN
name: OGDHL
boundary condition: true
type: Species
is encoded by: hsa:55753
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q9ULD0

MODEL1310110052#
species: metaM chsterol e
species: metaM 4mop c
species: metaM h r
species: metaM cs a deg2 l
species: metaM tymsf c
species: metaM core6 l
species: metaM c6dc x
species: metaM doco13ecoa c
species: metaM nadp c
species: metaM glx m
species: metaM thcholstoic x
species: metaM dmnoncrn c
species: metaM retinal 11 cis c
species: metaM dgdp c
name: HEXA:HEXB
species: metaM ksii core2 pre6 g
species: metaM dag hs c
species: metaM gchola e
species: metaM 4mptnl e
species: metaM 4hphac e
species: metaM acgpail hs c
species: metaM cmpacna c
species: metaM paf hs e
species: metaM mthgxl c
species: metaM dheas c
species: metaM 3pg c
species: metaM fru e
species: metaM ptdca c
species: metaM tettet6coa x
species: metaM so3 m
species: metaM m6mpdol L r
species: metaM f6p c
species: metaM bhb e
species: metaM gcald c
species: metaM h2o e
stoichiometry: 0.31269
species: metaM dump m
species: metaM pristcoa x
species: metaM nrpphr e
species: metaM coa l
species: metaM phyt c
species: metaM apoC Lys btn c
species: metaM tetpent6coa c
stoichiometry: 1.5
species: metaM inost e
species: metaM betald c
species: metaM dopasf c
name: ATP1A1:ATP1B1
species: metaM e4hglu m
species: metaM rbt e
species: metaM lald D c
species: metaM ksii core2 pre1 g
species: metaM g3pc c
species: metaM ksi deg9 l
species: metaM btamp m
species: metaM strdnc c
species: metaM pyr x
species: metaM dudp n
species: metaM pchol hs m
species: metaM h2o2 c
species: metaM pail3p hs n
species: metaM HC02205 c
species: metaM ach c
species: metaM nac c
species: metaM ocdca e
species: metaM pheme e
species: metaM cs b deg1 l
species: metaM hexdiac r
species: metaM anth c
species: metaM g3p c
species: metaM m2gacpail hs r
species: metaM hdd2crn c
species: metaM lneldccoa m
stoichiometry: 0.046571
species: metaM acrn c
species: metaM utp e
species: metaM caro e
species: metaM dopa c
species: metaM dtdp n
species: metaM s2l2n2m2masn l

metaR PGI
is version of: http://identifiers.org/ec-code/5.3.1.9
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
fast: false
name: glucose-6-phosphate isomerase
reactant: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000176
type: Reaction
reversible: true
modifier: MODEL1310110052#
is described by: ECO:0000134

metaM HC02180 e
is: CHEBI:28728
is: SBO:0000247
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
type: Species
initial concentration: 1.0
name: thromboxane-b2
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_e1142416_62b5_43e2_99c9_2712e3f19de3
constant: false
is encoded by: hsa:AI694761
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
name: _AI694761_1_c
is: SBO:0000252

metaM pyr e
is: CHEBI:15361
is: SBO:0000247
name: pyruvate
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
constant: false
initial concentration: 1.0
is: HMDB00243
initial amount: NaN

metaR CMPACNAtg
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
product: MODEL1310110052#
reactant: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
type: Reaction
name: CMP-Sia Golgi transport via CMP antiport
is: SBO:0000185
kinetic law: MODEL1310110052#
is described by: ECO:0000269
reversible: true

metaM mn l
name: beta-1,4-mannose-N-acetylglucosamine
initial amount: NaN
boundary condition: false
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
has only substance units: false
is: SBO:0000247
constant: false
type: Species
is: HMDB06535
initial concentration: 1.0

metaM leuktrD4 e
initial amount: NaN
is: HMDB03080
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
boundary condition: false
name: Leukotriene D4
is: SBO:0000247
constant: false
is: CHEBI:28666
has only substance units: false
initial concentration: 1.0
type: Species

metaM gua e
is: CHEBI:16235
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: SBO:0000247
name: guanine
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00132
type: Species

metaR EX dmantipyrine LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: demethylated antipyrine exchange
type: Reaction

metaM q10h2 m
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: HMDB13111
type: Species
name: Ubiquinol-10
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/6504740

metaR C100CPT1
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decanoylcarnitine
type: Reaction

metaR r1492
reversible: false
reactant: MODEL1310110052#
name: Utilized transport
is: SBO:0000185
product: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false

metaM aicar c
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
has only substance units: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: HMDB01517
constant: false
is: C04677
type: Species
is: CHEBI:58475
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_8fa4a037_5491_4e62_8c0b_9a99da2e3670
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: ALDOC
initial amount: NaN
constant: false
is encoded by: hsa:230
is: P09972

metaM CE2435 m
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57795
type: Species
name: trans,cis-deca-2,4-dienoyl-CoA
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435

metaM Rtotal e
is: HMDB00244
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
name: R total
constant: false
notes: FORMULA: CO2FULLR CHARGE: -1
is: C00255
is: CHEBI:3554
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_9c1933ae_40ff_4e5b_9136_8584717b8af0
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:7498
is: SBO:0000252
type: Species
initial amount: NaN
is: P47989
name: XDH
initial concentration: NaN

metaR P4508B13r
name: sterol 12-alpha-hydroxylase (nadh)
type: Reaction
is: SBO:0000176
reactant: MODEL1310110052#
reversible: false
fast: false
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
kinetic law: MODEL1310110052#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.13.95
modifier: MODEL1310110052#

metaM dgchol e
constant: false
name: glycochenodeoxycholate
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:36252
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
has only substance units: false
boundary condition: false
is: HMDB00637

http://identifiers.org/biomodels.db/MODEL1310110052#_b1ae82df_3945_4a25_b4cd_1aac25379a78
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
name: NDUFA11
initial amount: NaN
is encoded by: hsa:126328
constant: false
is: C9JT23

metaR PRGNLONEtm
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
fast: false
reversible: true
name: pregnenolone intracellular transport
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_509ab3a3_9225_43b9_bf87_e34837a6047f
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:7296
name: TXNRD1
constant: false
type: Species

metaR MI134P4P
type: Reaction
fast: false
name: inositol-1,3,4-trisphosphate 4-phosphatase
reactant: MODEL1310110052#
is: SBO:0000176
product: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110052#_fe04b3d6_12cf_4ace_b842_dd72d3c53da5
name: ESCO2
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:157570
is: SBO:0000252
is: Q56NI9
constant: false

metaR IVCOAACBP
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Isovaleryl-CoA from mitochondria into cytosol
type: Reaction

metaR EX 3ttetddcoacrn
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy trans5,8tetradecadienoyl carnitine
type: Reaction

metaR GGH 7THFe
modifier: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (7THF), extracellular
reversible: false
is: SBO:0000176
fast: false
type: Reaction

metaR FAOXC5C5DCc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of glutaryl carnitine
type: Reaction

metaR PTE3x
name: peroxisomal acyl-CoA thioesterase
fast: false
reactant: MODEL1310110052#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110052#
reversible: false
is described by: ECO:0000000
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.2.2

http://identifiers.org/biomodels.db/MODEL1310110052#_641de73c_c084_414a_af71_4c96e686cb97
is: Q9Y5B8
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
name: NME7
is encoded by: hsa:29922

metaM leuktrD4 c
has only substance units: false
is: SBO:0000247
constant: false
name: Leukotriene D4
initial amount: NaN
type: Species
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
boundary condition: false
is: HMDB03080
initial concentration: 1.0
is: CHEBI:28666

metaR ADNK1m
product: MODEL1310110052#
name: adenosine kinase, mitochondrial
fast: false
is described by: ECO:0000000
reactant: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.20 Confidence Level: 1 AUTHORS: NOTES:IT

metaR r1658
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110052#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110052#
fast: false
modifier: MODEL1310110052#

metaR PAPStg
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: true
name: 3'-Phosphoadenylyl sufate Golgi transport
is described by: ECO:0000269
is: SBO:0000185
fast: false
modifier: MODEL1310110052#

metaM CE2839 e
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247
constant: false
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
initial concentration: 1.0
initial amount: NaN
type: Species
name: maltodecaose
is: C01936

http://identifiers.org/biomodels.db/MODEL1310110052#_b278fd87_d9c7_4c4f_b117_958aa4eea223
initial concentration: NaN
type: Species
is encoded by: hsa:53354
name: PANK1
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_a1ac44b6_8df0_44f0_8e01_86dea9bf9c07
boundary condition: true
has only substance units: false
is: Q9Y6M9
initial concentration: NaN
name: NDUFB9
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:4715

metaR NAIt
name: Na+ / iodide cotransport
type: Reaction
product: MODEL1310110052#
is: SBO:0000185
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
reactant: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
reversible: true
is described by: ECO:0000269

metaR INSTt2r
type: Reaction
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
fast: false
modifier: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000185
name: inositol transport in via proton symport
reversible: true
reactant: MODEL1310110052#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110052#_ef331b86_d2da_4501_ad68_1db370bc01e4
is: SBO:0000252
name: _AI971036_1_m
type: Species
initial concentration: NaN
is encoded by: hsa:AI971036
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_61fdde08_82e9_4464_97f2_db944355d46b
is encoded by: hsa:28976
boundary condition: true
name: ACAD9
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is: Q9H845
initial concentration: NaN

metaR CHOLK
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.1.32
is described by: ECO:0000269
reactant: MODEL1310110052#
reversible: false
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Choline kinase
product: MODEL1310110052#

metaR 4MPTNLte
is: SBO:0000185
reactant: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: true
name: 4-methylpentanal transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:

metaM Rtotal c
notes: FORMULA: CO2FULLR CHARGE: -1
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:16189
has only substance units: false
is: HMDB01448
initial concentration: 1.0
name: R total
type: Species
is: SBO:0000247

metaM his L e
is: HMDB00177
type: Species
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
has only substance units: false
name: L-histidine
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:15971
initial amount: NaN

metaR TRDR
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.8.1.9
fast: false
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
type: Reaction
name: thioredoxin reductase (NADPH)
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110052#
reversible: false

metaR r1659
is described by: ECO:0000000
modifier: MODEL1310110052#
is: SBO:0000185
reactant: MODEL1310110052#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110052#
fast: false

metaR C204CRNt
is described by: ECO:0000000
product: MODEL1310110052#
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110052#
name: arachidonic acid transport into the mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
reversible: false
reactant: MODEL1310110052#

metaM tetpent6coa c
boundary condition: false
name: tetracosapentaenoyl coenzyme A, n-6
is: SBO:0000247
is: C16172
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_9388f3c9_d852_4808_9795_12ee1c809695
constant: false
is encoded by: hsa:79966
type: Species
is: Q86SK9
name: SCD5
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR FAOXC165C164m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

metaM ile L c
constant: false
name: L-isoleucine
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17191
boundary condition: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: HMDB00172
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_be698327_fab1_4a2d_986d_0dda003551d1
is: SBO:0000252
initial amount: NaN
name: TM7SF2
boundary condition: true
is: O76062
has only substance units: false
constant: false
type: Species
is encoded by: hsa:7108
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_2e561816_dda2_4005_bda7_88c4c9b0cdfb
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8395
is: O14986
constant: false
name: PIP5K1B
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_5487330f_16c5_4229_8880_696354bba47d
initial concentration: NaN
name: PLCH2
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:9651
constant: false
is: O75038
type: Species

metaR UMPK3
reactant: MODEL1310110052#
is described by: ECO:0000269
reversible: true
fast: false
product: MODEL1310110052#
name: UMP kinase (UTP)
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110052#
is: SBO:0000176

metaM 4izp c
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB01014
initial concentration: 1.0
name: 4-Imidazolone-5-propanoate
boundary condition: false
has only substance units: false
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
constant: false
is: CHEBI:57255

metaR OCD11CRNCPT2
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaM oh1 e
notes: FORMULA: HO CHARGE: -1
name: hydroxide ion
is: HMDB01039
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: C01328
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_5c361dcc_b86a_4ea1_8a1a_4bf3aef68fe6
type: Species
is: Q8NE62
has only substance units: false
boundary condition: true
is encoded by: hsa:55349
name: CHDH
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_64ae2173_c3ef_47ee_87d5_274ea22ffa1e
initial amount: NaN
is: A5JJ20
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:8671
type: Species
initial concentration: NaN
name: SLC4A4

http://identifiers.org/biomodels.db/MODEL1310110052#_b40b6d9c_d3b0_4c3a_8676_123cec21634b
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:262
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: AMD1
is: P17707

metaR RE0926E
modifier: MODEL1310110052#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
type: Reaction
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
name: RE0926
is version of: http://identifiers.org/ec-code/3.2.1.1
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is described by: ECO:0000000
product: MODEL1310110052#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110052#_871f61b2_a821_4451_bb66_8d481a247d8e
boundary condition: true
initial amount: NaN
constant: false
type: Species
name: GUCY1B2
has only substance units: false
is encoded by: hsa:2974
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_98901fd8_8213_4cf1_8699_619c8821e045
name: PIK3CD:PIK3R1
initial concentration: NaN
constant: false
is: SBO:0000297
has only substance units: false
boundary condition: true
has part: E7EX19
initial amount: NaN
is encoded by: hsa:5295
type: Species

metaM HC02205 c
type: Species
boundary condition: false
is: SBO:0000247
constant: false
name: prostaglandin-b2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
initial concentration: 1.0
has only substance units: false
is: CHEBI:28099
initial amount: NaN

metaR UMPK4
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110052#
name: UMP kinase (GTP)
reactant: MODEL1310110052#
is described by: ECO:0000269
modifier: MODEL1310110052#
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110052#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110052#_9e338337_c7d7_4048_a1d7_50a38b2eddb3
constant: false
name: _H45672_1_m
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:H45672

metaR PMTCOAtx
type: Reaction
reversible: true
name: fatty acid intracellular transport
kinetic law: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000185
fast: false

metaR r0963
product: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
reversible: false
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
kinetic law: MODEL1310110052#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaM bamppald c
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
constant: false
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
name: beta-Aminopropion aldehyde
initial concentration: 1.0
is: HMDB01106
is: http://identifiers.org/pubchem.compound/7975
is: C05665

metaR NDPK5n
is: SBO:0000176
is described by: ECO:0000304
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
product: MODEL1310110052#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
modifier: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_89e610e9_68bc_4e2c_ba4e_8f0f936c1ba6
initial concentration: NaN
is encoded by: hsa:9107
initial amount: NaN
is: SBO:0000252
type: Species
name: MTMR6
constant: false
is: Q9Y217
boundary condition: true
has only substance units: false

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

metaR UMPK5
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
modifier: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
name: UMP kinase (dATP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110052#_ae42d1d9_551e_495d_95a6_e6c534229452
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P46459
type: Species
initial amount: NaN
constant: false
name: NSF
is encoded by: hsa:4905
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_5d7957ce_45e9_45e4_a2a2_e66c4e34ad64
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
is: Q16718
name: NDUFA5
initial amount: NaN
is encoded by: hsa:4698

metaR SUCOASm
fast: false
reactant: MODEL1310110052#
is: SBO:0000176
modifier: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
is version of: http://identifiers.org/ec-code/6.2.1.5
type: Reaction
name: Succinate--CoA ligase (ADP-forming)
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110052#
reversible: true
is described by: ECO:0000000

metaR EX 3aib LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-3-Amino-isobutanoate exchange
type: Reaction

metaM s2l2n2m2mn l
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C76H123N5O57 CHARGE: -2
has only substance units: false
is: SBO:0000247
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)
is: HMDB00573
initial amount: NaN
boundary condition: false
is: CHEBI:30825

metaM cs a l
has only substance units: false
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
constant: false
type: Species
is: CHEBI:36005
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB02183

metaR FAOXC8C6m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)m
type: Reaction

metaR FACOAL2252
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
is: SBO:0000176
reversible: true
name: fatty-acid--CoA ligase

metaM ile L e
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
name: L-isoleucine
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:17191
initial amount: NaN
is: HMDB00172
type: Species
boundary condition: false
constant: false

metaR r0962
is: SBO:0000185
product: MODEL1310110052#
fast: false
reversible: false
name: Facilitated diffusion
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:

metaR FAOXC200180m
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110052#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of long chain fatty acid
reversible: false
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110052#
type: Reaction
is: SBO:0000176

metaR C120CPT1
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanoylcarnitine
type: Reaction

metaM glyclt c
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00115
name: glycolate
boundary condition: false
is: CHEBI:29805
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160

metaR PETHCT
is: SBO:0000176
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (5833.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.14 Confidence Level: 4 AUTHORS: NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.7.14
type: Reaction
product: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
name: phosphoethanolamine cytidyltransferase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110052#_7712f167_61ff_417d_b246_a24e2153818f
constant: false
initial concentration: NaN
name: PPAP2A
is encoded by: hsa:8611
is: SBO:0000252
boundary condition: true
is: G3XA95
initial amount: NaN
type: Species
has only substance units: false

metaR EX nrvnc LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nervonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_fb69622f_2cf1_4b2f_893f_99b77ac31e5c
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is: O95168
constant: false
name: NDUFB4
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4710

metaM oh1 c
has only substance units: false
is: HMDB01039
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
is: C01328
notes: FORMULA: HO CHARGE: -1
name: hydroxide ion

metaR BTND1
product: MODEL1310110052#
name: biotinidase (biotin)
kinetic law: MODEL1310110052#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:IT
type: Reaction
modifier: MODEL1310110052#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.12
is described by: ECO:0000269
reactant: MODEL1310110052#

metaR r0390
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110052#
fast: false
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
product: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction
reversible: true

metaM xan c
constant: false
is: CHEBI:17712
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
initial amount: NaN
is: C00385
boundary condition: false
name: Xanthine
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00292
initial concentration: 1.0

metaM malttr e
is: C01835
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: maltotriose
constant: false
is: CHEBI:27931
is: HMDB01262
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835

http://identifiers.org/biomodels.db/MODEL1310110052#_633f567d_5bbf_41f4_a50d_85ad34d7f978
name: PLCB4
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: E2QRH8
is encoded by: hsa:5332
is: SBO:0000252

metaR EX 3hdececrn
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecenoyl carnitine
type: Reaction

metaR IPDPtx
fast: false
name: Isopentenyl diphosphate transport (peroxisome)
reactant: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
is: SBO:0000185
product: MODEL1310110052#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
reversible: true

metaR EX dgsn LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyguanosine
type: Reaction

metaR UMPK2
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000269
fast: false
product: MODEL1310110052#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (CTP)
is: SBO:0000176
kinetic law: MODEL1310110052#

metaR TRDRm
notes: GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES:NCD
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.8.1.9
kinetic law: MODEL1310110052#
is described by: ECO:0000269
name: thioredoxin reductase (NADPH)

http://identifiers.org/biomodels.db/MODEL1310110052#_e98564b6_ea06_4b03_911a_2065dd45526a
constant: false
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:55825
name: PECR
is: Q9BY49
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM pyr m
is: CHEBI:15361
is: HMDB00243
is: SBO:0000247
boundary condition: false
is: C00022
is: http://identifiers.org/pubchem.compound/3324
name: pyruvate
initial concentration: 1.0
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
has only substance units: false
type: Species
initial amount: NaN
constant: false

metaM cs e deg3 l
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00127
notes: FORMULA: C37H53NO44S4 CHARGE: -6
initial amount: NaN
is: CHEBI:15748
constant: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
boundary condition: false
type: Species

metaR GAPD
kinetic law: MODEL1310110052#
fast: false
type: Reaction
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.2.1.12
reactant: MODEL1310110052#
is described by: ECO:0000134
name: glyceraldehyde-3-phosphate dehydrogenase
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
is: SBO:0000176
product: MODEL1310110052#
reversible: true

metaR ACRNtm
name: O-acetylcarnintine transport into mitochondria via diffusion
is described by: ECO:0000269
reactant: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
reversible: false
kinetic law: MODEL1310110052#
is: SBO:0000185
product: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:977593 NOTES:NCD

metaR r0960
reactant: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
type: Reaction
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000000

metaM c4dc c
is: C02862
name: succinyl carnitine
initial concentration: 1.0
is: HMDB02013
notes: FORMULA: C11H18NO6 CHARGE: -1
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/213144
has only substance units: false

metaR ARACHCOAtx
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
fast: false
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000000

metaR MCITS
product: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
is: SBO:0000176
name: 2-methylcitrate synthase
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 2.3.3.5 Confidence Level: 2 AUTHORS: PMID:426765,PMID:4507604 NOTES:NCD new EC is 2.3.3.5 - NCD

http://identifiers.org/biomodels.db/MODEL1310110052#_f642bde1_acf7_4ec6_8c08_f798a607f378
is: Q5SYN6
type: Species
name: SLC22A3
is encoded by: hsa:6581
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_1cfd56bc_9422_432c_a84e_cac312be66a2
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:386757
type: Species
name: SLC6A10P
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR DGULND
kinetic law: MODEL1310110052#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110052#
reversible: true
product: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
is described by: ECO:0000000
name: dehydro-L-gulonate decarboxylase

metaR r0392
reactant: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3

metaM ksi pre11 g
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28067
type: Species
name: keratan sulfate I biosynthesis, precursor 11
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C129H208N9O101S3X CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110052#_ceffbab2_a832_4b1a_a7c0_6d40a3bce621
has only substance units: false
constant: false
name: OXCT2
is encoded by: hsa:64064
is: SBO:0000252
is: Q9BYC2
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR MI145PK
product: MODEL1310110052#
name: inositol-1,4,5-trisphosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.127
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
fast: false
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110052#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_f3033787_8d75_49bd_987d_bf3ac5e01269
is encoded by: hsa:3418
has only substance units: false
initial concentration: NaN
type: Species
name: IDH2
boundary condition: true
is: P48735
constant: false
is: SBO:0000252
initial amount: NaN

metaM dlnlcgcoa m
name: dihomo-gamma-linolenyl coenzyme A
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:27979
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_121ed1b4_7b98_4bfe_9819_086fbaec70b0
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P02730
constant: false
is encoded by: hsa:6521
name: SLC4A1
boundary condition: true
initial concentration: NaN
type: Species

metaR SIAASE4ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.6.4
name: sialidase, lysosomal
fast: false
product: MODEL1310110052#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR r0391
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
reactant: MODEL1310110052#
reversible: true
type: Reaction
fast: false
product: MODEL1310110052#
kinetic law: MODEL1310110052#
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
is: SBO:0000176

metaR EX phyt LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phytanic acid exchange
type: Reaction

metaR PI45P3K
reactant: MODEL1310110052#
type: Reaction
modifier: MODEL1310110052#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.11.1
kinetic law: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
fast: false
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.1.153

metaR PI4P3K
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.11.1
kinetic law: MODEL1310110052#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.154
name: phosphatidylinositol 4-phosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.153
product: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
reversible: false
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD

metaM Asn X Ser Thr r
initial concentration: 1.0
is: SBO:0000247
name: protein-linked asparagine residue (N-glycosylation site)
is: C01342
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00051
constant: false
notes: FORMULA: XH CHARGE: 0
is: CHEBI:28938

metaM c4dc e
is: C02862
is: HMDB02013
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: succinyl carnitine
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C11H18NO6 CHARGE: -1
constant: false
is: http://identifiers.org/pubchem.compound/213144

http://identifiers.org/biomodels.db/MODEL1310110052#_30ccd364_e83b_4c2b_b053_37b0cc93bca3
is: Q9UJM8
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: HAO1
initial concentration: NaN
is encoded by: hsa:54363
is: SBO:0000252
boundary condition: true

metaR FACOAL2042
reactant: MODEL1310110052#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
product: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
name: fatty-acid--CoA ligase
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000

metaR FUM
product: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/4.2.1.2
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110052#
name: fumarase
is: SBO:0000176
kinetic law: MODEL1310110052#

metaR RE3272N
reactant: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000176
name: RE3272
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
type: Reaction
is described by: ECO:0000000

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR PHEACGLNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
name: PHEACGLN extracellular transport via diffusion
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#

metaR r0394
product: MODEL1310110052#
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000176
is described by: ECO:0000000

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_5d482764_ae2f_4d56_9ada_60c9afa85234
constant: false
initial concentration: NaN
has only substance units: false
type: Species
name: COL4A3BP
is: SBO:0000252
is: Q9Y5P4
initial amount: NaN
boundary condition: true
is encoded by: hsa:10087

metaM HC00900 m
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:30860
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
type: Species
boundary condition: false
name: Methylmalonate

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaR FAOXC184C164m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)m
type: Reaction

metaM ksi pre14 g
is: CHEBI:28067
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
type: Species
name: keratan sulfate I biosynthesis, precursor 14
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_3b043815_d072_4c5e_b41b_7875932de1e2
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is: Q4J699
type: Species
is encoded by: hsa:491
name: ATP2B2
boundary condition: true

metaM HC02205 e
boundary condition: false
name: prostaglandin-b2
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:28099
initial concentration: 1.0

metaM 35cgmp c
has only substance units: false
is: HMDB01314
is: CHEBI:57746
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
name: 3',5'-cyclic GMP(1-)
constant: false
initial concentration: 1.0

metaR RE1532M
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110052#
name: RE1532
fast: false
product: MODEL1310110052#

metaR OCD11COACPT1
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR r0393
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
product: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
reversible: false
modifier: MODEL1310110052#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.1.74

metaM ksi pre6 g
boundary condition: false
is: HMDB00175
is: C00130
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 6
initial amount: NaN
has only substance units: false
notes: FORMULA: C107H174N7O80SX CHARGE: -2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_01ae4e53_8c05_47d6_9e44_4aad46c769b6
is: SBO:0000252
type: Species
is encoded by: hsa:6818
boundary condition: true
has only substance units: false
is: P50224
initial amount: NaN
initial concentration: NaN
name: SULT1A3
constant: false

metaR VITD3t2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
product: MODEL1310110052#
reversible: false
is: SBO:0000185
name: Vitamin D3 uptake
kinetic law: MODEL1310110052#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110052#
type: Reaction

metaR SPH1Pte
reactant: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110052#
name: sph1p transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110052#_17c1047b_e337_4b3b_8042_416de57f82ec
is: P27707
is: SBO:0000252
name: DCK
initial concentration: NaN
is encoded by: hsa:1633
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_319110f4_3284_4d4b_8e48_625cd91a1642
type: Species
is: Q8TBF5
has only substance units: false
initial amount: NaN
name: PIGX
is encoded by: hsa:54965
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_04231aea_ce1f_4a66_9e3d_d60072f30277
initial concentration: NaN
name: TUSC3
is: Q13454
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:7991
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_24ccd99c_03e5_4fe1_bee1_c89f70cd1e76
boundary condition: true
type: Species
is encoded by: hsa:10935
is: P30048
constant: false
name: PRDX3
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR PUNP4
is: SBO:0000176
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
modifier: MODEL1310110052#
type: Reaction
reversible: true
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
name: purine-nucleoside phosphorylase (Deoxyguanosine)
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1

metaM c12dccoa c
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
name: dodecanedioylcoa
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00623
type: Species
has only substance units: false
is: SBO:0000247
constant: false

metaM biocyt c
constant: false
initial concentration: 1.0
is: C05552
is: HMDB03134
is: http://identifiers.org/pubchem.compound/7886
is: SBO:0000247
boundary condition: false
has only substance units: false
name: Biocytin
initial amount: NaN
type: Species
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552

metaR OCT11EFATP
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of vaccenic acid by cells
type: Reaction

metaM sebacid c
is: HMDB00792
is: C08277
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C10H16O4 CHARGE: -2
name: sebacicacid
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_3f281ef9_091e_4a3c_acff_209ea1fc4f9f
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q5FC00
type: Species
initial concentration: NaN
constant: false
name: CA6
is: SBO:0000252
is encoded by: hsa:765

metaM biocyt e
is: SBO:0000247
is: HMDB03134
is: http://identifiers.org/pubchem.compound/7886
has only substance units: false
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: C05552
constant: false
type: Species
initial amount: NaN
name: Biocytin
boundary condition: false
initial concentration: 1.0

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaR VACCt
fast: false
product: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
is: SBO:0000185
name: fatty acid transport via diffusion
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaR GALASE4ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
is: SBO:0000176
name: beta-galactosidase, lysosomal
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110052#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#

metaM 3hdeccoa c
type: Species
is: HMDB02014
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
constant: false
name: 3-hydroxyhexadecenoylcoa
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR BTNPLm
is described by: ECO:0000000
kinetic law: MODEL1310110052#
product: MODEL1310110052#
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
modifier: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
reversible: false
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.10
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism

http://identifiers.org/biomodels.db/MODEL1310110052#_a7845364_edd2_40ba_874d_d2df75cd156a
initial concentration: NaN
boundary condition: true
is encoded by: hsa:23439
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is: Q9UN42
type: Species
name: ATP1B4

metaR C160CRNt
is described by: ECO:0000269
product: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
name: C160 transport into the mitochondria
is: SBO:0000185
reactant: MODEL1310110052#
reversible: false
modifier: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_3c54d6f3_f14f_4f0f_8164_13bc9289ca1b
name: MTMR2
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8898
boundary condition: true
is: A6NN98
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_ad242bf5_22ce_42d8_9332_96d8e71efe2f
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
name: AOC2
is encoded by: hsa:314
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_aca56c51_3240_4750_a990_9ee15186e120
is: Q96P26
constant: false
boundary condition: true
is encoded by: hsa:93034
name: NT5C1B
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN

metaR ACOAO7p
reversible: false
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
modifier: MODEL1310110052#
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
fast: false
kinetic law: MODEL1310110052#
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110052#_944fcb8c_2812_4751_8aa0_1b588f593ea3
constant: false
initial amount: NaN
name: PKM2
boundary condition: true
is encoded by: hsa:5315
is: P14618
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR 3AIBTm
fast: false
modifier: MODEL1310110052#
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.6.1.19
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD
name: L-3-aminoisobutyrate transaminase, mitochondrial
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reversible: true
is: SBO:0000176

metaM glyc3p c
initial concentration: 1.0
is: CHEBI:57597
initial amount: NaN
is: SBO:0000247
is: C00093
is: HMDB00126
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
name: Glycerol 3-phosphate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_715bc7dc_10eb_4fe9_84ba_d43d188a8e18
initial concentration: NaN
constant: false
has only substance units: false
name: UCK1
is: Q5JT09
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:83549

metaM fadh2 m
has only substance units: false
is: C01352
name: Flavin adenine dinucleotide reduced
initial concentration: 1.0
type: Species
is: CHEBI:58307
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: HMDB01197
initial amount: NaN

metaM tdec4ecoa m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
is: C08277
is: HMDB00792
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
name: trans4decenoylcoa
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_f343b3f7_25d6_455b_9bb8_a0d47f87a523
is: SBO:0000252
name: ALDH3B1
is: P43353
is encoded by: hsa:221
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
type: Species

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

metaM ksi deg30 l
name: keratan sulfate I, degradation product 30
has only substance units: false
is: HMDB00143
initial amount: NaN
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:12936
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_6815b1db_08f6_4d08_8639_76cd18ad7600
initial concentration: NaN
name: SLC27A5
constant: false
is: Q9Y2P5
initial amount: NaN
type: Species
is encoded by: hsa:10998
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR RE0583C
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
product: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
name: RE0583
reactant: MODEL1310110052#
type: Reaction

metaM ksii core4 pre2 g
is: C00130
name: keratan sulfate II boisynthesis, precursor 2
type: Species
notes: FORMULA: C47H76N4O33X CHARGE: -1
boundary condition: false
constant: false
is: HMDB00175
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58053
has only substance units: false

metaM pyr x
type: Species
initial amount: NaN
is: C00022
has only substance units: false
constant: false
is: HMDB00243
is: http://identifiers.org/pubchem.compound/3324
initial concentration: 1.0
name: pyruvate
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: CHEBI:15361
is: SBO:0000247
boundary condition: false

metaR DMATTx
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
fast: false
kinetic law: MODEL1310110052#
name: dimethylallyltranstransferase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.1
product: MODEL1310110052#
is described by: ECO:0000134
reactant: MODEL1310110052#
modifier: MODEL1310110052#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_5d5b5b0a_e4d6_4726_a065_8d85a89148fd
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10195
initial amount: NaN
constant: false
name: ALG3
has only substance units: false
type: Species

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_3af08085_b293_4185_957f_18a481851640
is: SBO:0000297
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:2974
initial concentration: NaN
constant: false
name: GUCY1B2:GUCY1A3
boundary condition: true
is encoded by: hsa:2982
has part: D6RDW3

http://identifiers.org/biomodels.db/MODEL1310110052#_4bc9ac3b_96a5_4b58_b21a_999af9468ae9
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q01581
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:3157
name: HMGCS1

http://identifiers.org/biomodels.db/MODEL1310110052#_4e359d2a_2164_4617_be96_0e3cade7bf23
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is: P61457
initial amount: NaN
constant: false
name: PCBD1
has only substance units: false
is encoded by: hsa:5092

metaM btn m
initial amount: NaN
boundary condition: false
is: CHEBI:57586
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00030
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
is: SBO:0000247
name: biotinate

metaR PUNP3
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.2.1
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000176
fast: false
modifier: MODEL1310110052#
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Guanosine)
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110052#_d24f22ab_b0c9_4215_b2ef_e6f95a5f70cd
is encoded by: hsa:7358
initial concentration: NaN
is: O60701
is: SBO:0000252
initial amount: NaN
name: UGDH
constant: false
boundary condition: true
has only substance units: false
type: Species

metaM dlnlcgcoa c
boundary condition: false
is: CHEBI:27979
has only substance units: false
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
initial concentration: 1.0
is: SBO:0000247
name: dihomo-gamma-linolenyl coenzyme A

metaM pristcoa c
initial concentration: 1.0
initial amount: NaN
name: pristanoyl coa
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
has only substance units: false
boundary condition: false
is: CHEBI:51341
type: Species
constant: false
is: SBO:0000247

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaM mag hs c
initial concentration: 1.0
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
name: monoacylglycerol 2
is: CHEBI:60479
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR r2420
is: SBO:0000185
product: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reversible: true
reactant: MODEL1310110052#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_aea35f7e_264f_4130_a9a2_4e019ce4462c
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: LDHAL6B
is: Q9BYZ2
type: Species
is encoded by: hsa:92483
initial amount: NaN
has only substance units: false

metaR r0377
modifier: MODEL1310110052#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
kinetic law: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000000
reactant: MODEL1310110052#
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
fast: false

metaR AMANK
kinetic law: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
is: SBO:0000176
name: N-acetyl-D-mannosamine kinase
is version of: http://identifiers.org/ec-code/2.7.1.59
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.3.14
notes: GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES:JLR - Kegg R02705
modifier: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000269

metaR DECDICRNe
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of decadienoyl carnitine into the extra cellular space
type: Reaction

metaM saccrp L m
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C11H19N2O6 CHARGE: -1 INCHI: InChI=1S/C11H20N2O6/c12-7(10(16)17)3-1-2-6-13-8(11(18)19)4-5-9(14)15/h7-8,13H,1-6,12H2,(H,14,15)(H,16,17)(H,18,19)/p-1/t7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00363
initial concentration: 1.0
has only substance units: false
is: CHEBI:57951
constant: false
name: L-saccharopinate(1-)
is: HMDB00279
boundary condition: false

metaM ksi pre29 g
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 29
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C213H340N15O179S9X CHARGE: -10

metaR EX adp
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adp exchange
type: Reaction

metaM cmpacna c
boundary condition: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
name: CMP-N-acetyl-beta-neuraminate(2-)
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB01176
is: CHEBI:57812
initial amount: NaN
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_020bff85_3df0_47a6_861f_c5af20999398
is: P00374
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: DHFR
is encoded by: hsa:1719
is: SBO:0000252
constant: false

metaR TYRTAm
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.1
modifier: MODEL1310110052#
reactant: MODEL1310110052#
reversible: true
fast: false
kinetic law: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (6898.1) or (2806.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: PMID:1973834 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.5
name: tyrosine transaminase, mitochondrial
type: Reaction

metaR HOMt4
type: Reaction
modifier: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
name: L-homoserine via sodium symport
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6541.1) or (84889.1) or (6542.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110052#_3f788b4c_fd4a_49c4_ae39_8e28f69352a2
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: P45954
initial concentration: NaN
name: ACADSB
is encoded by: hsa:36
is: SBO:0000252

metaR VALTA
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110052#
reactant: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
kinetic law: MODEL1310110052#
is described by: ECO:0000269
is: SBO:0000176
name: valine transaminase

http://identifiers.org/biomodels.db/MODEL1310110052#_2fac246a_5df7_422a_80ce_79ee73b632ee
name: PIK3CD:PIK3R3
is encoded by: hsa:8503
type: Species
has part: A7E2E0
is: SBO:0000297
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:5293
boundary condition: true
has part: Q92569

metaM dag hs c
name: diglyceride
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:18035
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110052#_b05f6390_4f77_4f4c_8c60_47cff215f476
has only substance units: false
is: Q06830
is encoded by: hsa:5052
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
name: PRDX1

metaR PUNP1
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110052#
is: SBO:0000176
modifier: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
type: Reaction
reversible: true
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Adenosine)

metaR r1751
kinetic law: MODEL1310110052#
fast: false
is: SBO:0000185
product: MODEL1310110052#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110052#
name: Y+LAT2 Utilized transport
type: Reaction
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR NRPPHRt4 2 r
kinetic law: MODEL1310110052#
name: Norepinephrine reversible transport in via sodium symport (1:2)
is: SBO:0000185
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110052#
type: Reaction
fast: false
product: MODEL1310110052#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_2c34efe3_eab6_49e6_8a87_68312d41419b
initial amount: NaN
type: Species
initial concentration: NaN
is: O43488
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
name: AKR7A2
is encoded by: hsa:8574

http://identifiers.org/biomodels.db/MODEL1310110052#_7736362a_ca73_4d5e_b563_9493aa0630fb
initial amount: NaN
is: P21399
is encoded by: hsa:48
type: Species
has only substance units: false
name: ACO1
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN

metaR FAOXC61C4m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

metaM mag hs e
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
is: CHEBI:60479
constant: false
name: monoacylglycerol 2
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_3eb76516_3f73_41ed_823b_5662bd8094b4
constant: false
is: O15496
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: PLA2G10
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:8399

metaM cs a deg2 l
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2
notes: FORMULA: C37H55NO38S2 CHARGE: -4
constant: false
is: HMDB00127
type: Species
is: CHEBI:15748
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_36259d02_9942_464b_9632_833118252887
constant: false
type: Species
is: SBO:0000252
name: SLC3A2
boundary condition: true
is: P08195
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6520

metaR RE3628M
reversible: true
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
type: Reaction
name: RE3628
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.3.3.8
product: MODEL1310110052#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_b3165e71_8501_4249_a105_3c43fda25e04
is: Q96AT9
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: RPE
is encoded by: hsa:6120
initial concentration: NaN
initial amount: NaN
constant: false

metaR FACOAL2251
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
type: Reaction
product: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110052#

metaM betald c
boundary condition: false
is: HMDB01252
name: betaine aldehyde
initial amount: NaN
constant: false
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
is: CHEBI:15710
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM 3ttetddcoa m
is: HMDB02014
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: 3-hydroxy trans5,8tetradecadienoyl coa
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
boundary condition: false
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_e9ee91f3_9a75_41ef_a5b2_eea70d674d02
is encoded by: hsa:84569
name: LYZL1
initial concentration: NaN
type: Species
is: Q6UWQ5
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN

metaR G14T11g
modifier: MODEL1310110052#
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
fast: false
reactant: MODEL1310110052#
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

http://identifiers.org/biomodels.db/MODEL1310110052#_6554ea3f_fee2_45bd_80f1_6bb299857cbc
is: E7EQF2
constant: false
name: CROT
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:54677

metaM succ m
initial amount: NaN
is: CHEBI:30031
is: SBO:0000247
is: C00042
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
initial concentration: 1.0
is: HMDB00254
boundary condition: false
type: Species
constant: false
name: Succinate
has only substance units: false

metaR DOLPMT4 Ler
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
reversible: false
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
product: MODEL1310110052#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110052#_95325a93_8be7_4f02_b5f9_8c00f11ae7e9
is encoded by: hsa:3417
is: O75874
initial concentration: NaN
type: Species
name: IDH1
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true

metaM tetpent3coa c
type: Species
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: C16167
name: tetracosapentaenoyl coenzyme A, n-3

metaR C10OHc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdecanoylcarnitinec
type: Reaction

metaM ksi pre33 g
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
constant: false
is: C00130
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 33
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:58053
type: Species
is: HMDB00175

metaR TETHEX3t
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
is: SBO:0000185
name: fatty acid transport via diffusion
fast: false
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction
product: MODEL1310110052#

metaR TETTET6t
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110052#
reversible: true
type: Reaction
name: fatty acid transport via diffusion
fast: false
is: SBO:0000185
reactant: MODEL1310110052#
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_f087d294_7715_479e_88d8_65ad1d7bea4b
type: Species
is encoded by: hsa:5295
name: PIK3R1
initial amount: NaN
is: SBO:0000252
is: E7EX19
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN

metaM oaa m
constant: false
name: Oxaloacetate
has only substance units: false
is: C00036
is: CHEBI:16452
is: SBO:0000247
is: HMDB00223
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
initial amount: NaN

metaR ACOAD9m
product: MODEL1310110052#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110052#
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_df1ea7dd_3e49_4642_9337_53960e8ec2c1
has only substance units: false
constant: false
name: ATP1B1
is: SBO:0000252
is encoded by: hsa:481
type: Species
boundary condition: true
initial amount: NaN
is: A3KLL5
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_228debff_322a_40f0_8402_ea603ea35434
type: Species
is: P31350
initial concentration: NaN
name: RRM2
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:6241

metaM ptdcacoa c
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB06499
initial amount: NaN
name: pentadecanoyl Coenzyme A
type: Species
constant: false
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1

metaR C142ACBP
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradeca dienoyl coa from mitochondria into cytosol
type: Reaction

metaR r0525
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.9 Confidence Level: 0 AUTHORS: PMID:235294,PMID:4774398 NOTES:
type: Reaction
kinetic law: MODEL1310110052#
reversible: true
fast: false
product: MODEL1310110052#
is described by: ECO:0000000
name: N6-(L-1,3-Dicarboxypropyl)-L-lysine:NAD+ oxidoreductase; N6-(L-1,3-Dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming) Lysine degradation EC:1.5.1.9
reactant: MODEL1310110052#

metaM nicrns c
constant: false
name: Nicotinate D-ribonucleoside
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58527
notes: FORMULA: C11H13NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01628 EHMN_ABBREVIATION: C05841
boundary condition: false
is: HMDB06809
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_fa8269f5_8b01_47eb_889b_2b1760df9b43
initial amount: NaN
has only substance units: false
type: Species
name: SLC1A4
is encoded by: hsa:6509
initial concentration: NaN
constant: false
is: SBO:0000252
is: P43007
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_57e8814e_423a_47fb_83fc_c0a9be20f7c6
initial amount: NaN
name: TM7SF2
has only substance units: false
boundary condition: true
is: O76062
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:7108
constant: false

metaR FAOXC164C165m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

metaR r0268
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
fast: false
product: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.3.1
kinetic law: MODEL1310110052#
is: SBO:0000176
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
reactant: MODEL1310110052#
type: Reaction
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.2

metaM pap c
is: SBO:0000247
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
boundary condition: false
name: adenosine 3',5'-bismonophosphate(4-)
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:58343
initial concentration: 1.0
is: HMDB00061
type: Species

metaR NDPK5
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
type: Reaction
is: SBO:0000176
fast: false
name: Nucleoside-diphosphate kinase (ATP:dGDP)
kinetic law: MODEL1310110052#
is described by: ECO:0000269
reactant: MODEL1310110052#
product: MODEL1310110052#

metaR r1643
product: MODEL1310110052#
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110052#_6cac3c96_1b5f_4f77_8f14_d3b5c5b5240f
initial concentration: NaN
is: P30838
name: ALDH3A1
type: Species
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:218
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_f9c94729_4109_495e_9df1_6fba74e5fb0a
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2098
is: SBO:0000252
constant: false
type: Species
is: P10768
initial amount: NaN
name: ESD

metaM fadh2 c
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB01197
type: Species
constant: false
is: CHEBI:58307
name: FADH2(2-)
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352

metaR ADPACDAc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of adipic acid for formation of adipoyl carnitine
type: Reaction

metaR C161CPT22
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110052#
type: Reaction
name: C161 transport into the mitochondria
kinetic law: MODEL1310110052#
fast: false
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110052#

metaM btn c
name: Biotin
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C10H15N2O3S CHARGE: -1
initial amount: NaN
is: CHEBI:3420
constant: false
is: C00120
is: HMDB00030
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_3f11b379_204a_4b4f_99bd_1ef0fc01a66c
name: SLC4A2
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6522
boundary condition: true
is: F8W682
initial concentration: NaN
initial amount: NaN

metaR FAOXC18C18OHm
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18-->C18OH)m
type: Reaction

metaM fe2 e
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
name: Fe2+
is: CHEBI:29033
is: HMDB00692
is: SBO:0000247
has only substance units: false
type: Species
is: C00023
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0

metaR FAOXC226
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
product: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: false
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
is: SBO:0000176

metaR ETF
modifier: MODEL1310110052#
reversible: false
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
name: electron transfer flavoprotein
product: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_916c9ab0_71b9_4d88_8f10_bbc1ba499e1e
is encoded by: hsa:5244
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
has only substance units: false
name: ABCB4
is: P21439
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_6da2fce0_918f_4617_896d_ba55de4e8c94
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: PEMT
has only substance units: false
boundary condition: true
is encoded by: hsa:10400
type: Species
constant: false

metaM succ c
is: C00042
initial concentration: 1.0
initial amount: NaN
name: Succinate
is: CHEBI:30031
is: SBO:0000247
has only substance units: false
is: HMDB00254
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
type: Species
constant: false

metaM m7masnB r
notes: FORMULA: C64H107N2O50X CHARGE: 0
initial amount: NaN
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: C05881

metaR r1088
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Active transport
kinetic law: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#
type: Reaction
is: SBO:0000185

metaR r1642
reactant: MODEL1310110052#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110052#

metaM glu L e
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:29985
has only substance units: false
name: L-glutamate(1-)
boundary condition: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: SBO:0000247
type: Species
is: HMDB00148

metaR NDPK6
type: Reaction
reactant: MODEL1310110052#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110052#
name: Nucleoside-diphosphate kinase (ATP:dUDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: true
is described by: ECO:0000269

metaM na1 x
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
initial concentration: 1.0
is: HMDB00588
name: sodium(1+)
boundary condition: false
is: CHEBI:29101

metaR GDPFUCtg
reactant: MODEL1310110052#
fast: false
name: GDPFuc Golgi transport via CMP antiport
type: Reaction
reversible: true
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
product: MODEL1310110052#
modifier: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_fc566dd2_7d48_4dae_9fbd_dd687532970c
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
name: PPT1
constant: false
is: Q6FGQ4
boundary condition: true
initial amount: NaN
is encoded by: hsa:5538

metaM gua c
name: Guanine
initial concentration: 1.0
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB00132
is: C00242
type: Species
constant: false
is: CHEBI:16235

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaR PI5P4K
reactant: MODEL1310110052#
name: phosphatidylinositol-5-phosphate 4-kinase
modifier: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.1.67
notes: GENE_ASSOCIATION: (5297.1) or (55361.1) or (5298.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.149 Confidence Level: 4 AUTHORS: PMID:10358929,PMID:9211928,PMID:9367159 NOTES:NCD

metaR r0527
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000176
type: Reaction

metaR RE3301C
reversible: true
is version of: http://identifiers.org/ec-code/3.1.4.4
is: SBO:0000176
kinetic law: MODEL1310110052#
name: RE3301
fast: false
modifier: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
reactant: MODEL1310110052#
type: Reaction

metaR A MANASEly
reversible: false
type: Reaction
name: alpha-mannosidase, lysosomal
modifier: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.2.1.24
fast: false
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
is: SBO:0000176
product: MODEL1310110052#
reactant: MODEL1310110052#

metaM 3dphb m
type: Species
name: 3-Decaprenyl-4-hydroxybenzoate
is: SBO:0000247
initial concentration: 1.0
is: HMDB06251
has only substance units: false
notes: FORMULA: C57H85O3 CHARGE: -1 INCHI: InChI=1/C57H86O3/c1-44(2)21-12-22-45(3)23-13-24-46(4)25-14-26-47(5)27-15-28-48(6)29-16-30-49(7)31-17-32-50(8)33-18-34-51(9)35-19-36-52(10)37-20-38-53(11)39-40-54-43-55(57(59)60)41-42-56(54)58/h21,23,25,27,29,31,33,35,37,39,41-43,58H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,59,60)/b45-23+,46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+
boundary condition: false
initial amount: NaN
constant: false

metaR r1645
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110052#
reversible: true
fast: false
reactant: MODEL1310110052#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110052#

metaR CRNtx
reactant: MODEL1310110052#
reversible: true
product: MODEL1310110052#
is: SBO:0000185
type: Reaction
name: carnitine transport peroxisome to mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
fast: false
kinetic law: MODEL1310110052#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110052#_f03cb61f_ec7d_4142_b0f4_95f014e8828e
initial concentration: NaN
is: Q7LG56
is: SBO:0000252
has only substance units: false
name: RRM2B
type: Species
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:50484

metaR NDPK7
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:dCDP)
product: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269

metaM pnto R e
is: CHEBI:7916
type: Species
name: (R)-Pantothenate
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: SBO:0000247
is: HMDB00210
initial amount: NaN
initial concentration: 1.0

metaM btn e
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: Biotin
type: Species
constant: false
is: CHEBI:3420
is: C00120
is: HMDB00030
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: SBO:0000247

metaR sink dd2coa LPAREN c RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: DD2COASINK
type: Reaction

metaR OCOAT1m
type: Reaction
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
name: 3-oxoacid CoA-transferase
product: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (5019.1) or (64064.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.8.3.5 Confidence Level: 4 AUTHORS: PMID:10964512,PMID:11756565 NOTES:TDV
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.3.5
reversible: true
is described by: ECO:0000269

metaR LEULEUPEPT1tc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR EX c3dc
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for malonyl carnitine
type: Reaction

metaM arachcrn m
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
name: arachidyl carnitine
is: HMDB06460

http://identifiers.org/biomodels.db/MODEL1310110052#_e4f21b06_6c87_4901_839c_cde303681958
boundary condition: true
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:23530
has only substance units: false
is: SBO:0000252
name: NNT

http://identifiers.org/biomodels.db/MODEL1310110052#_0f66ac0f_71b8_408d_b00b_0a9de86f6fd1
initial concentration: NaN
is: Q5JT09
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:83549
has only substance units: false
name: UCK1
constant: false

metaM ksii core2 deg6 l
is: CHEBI:12936
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C44H72N4O33SX CHARGE: -1
initial amount: NaN
name: keratan sulfate II (core 2-linked), degradation product 6
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: HMDB00143

metaR r1644
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
fast: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110052#
is: SBO:0000185
reversible: true

metaR r0267
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.5.1.9
is: SBO:0000176
kinetic law: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110052#
fast: false
reactant: MODEL1310110052#

metaR NDPK8
fast: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110052#
reversible: true
product: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
is: SBO:0000176
name: Nucleoside-diphosphate kinase (ATP:dADP)

http://identifiers.org/biomodels.db/MODEL1310110052#_d5ba4e49_a4b1_4686_9dac_07c7b0d8050a
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
name: PFKL
is: Q7L2M7
is encoded by: hsa:5211

http://identifiers.org/biomodels.db/MODEL1310110052#_2e20f4b9_eb80_4c4a_9f78_72b6edba32f9
initial concentration: NaN
type: Species
is: P50747
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:3141
initial amount: NaN
boundary condition: true
name: HLCS

metaM pap g
boundary condition: false
constant: false
is: SBO:0000247
name: adenosine 3',5'-bismonophosphate(4-)
is: HMDB00061
initial amount: NaN
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
initial concentration: 1.0
type: Species
is: CHEBI:58343
has only substance units: false

metaR NP1
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110052#
type: Reaction
is described by: ECO:0000304
name: nucleotide phosphatase
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: false
product: MODEL1310110052#
is: SBO:0000176
reactant: MODEL1310110052#

metaR ACHtn
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110052#
name: Acetylcholin transport, nuclear trhough pores
product: MODEL1310110052#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_7987b548_e3c8_47c4_ae9a_0105d3aab020
name: AOC3
is encoded by: hsa:8639
boundary condition: true
is: Q16853
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaR CRVNCtr
product: MODEL1310110052#
name: fatty acid transport via diffusion
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110052#
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110052#

metaM rnam c
constant: false
type: Species
name: N-Ribosylnicotinamide
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C11H15N2O5 CHARGE: 1 INCHI: InChI=1S/C11H14N2O5/c12-10(17)6-2-1-3-13(4-6)11-9(16)8(15)7(5-14)18-11/h1-4,7-9,11,14-16H,5H2,(H-,12,17)/p+1/t7-,8-,9-,11-/m1/s1 EHMN_ABBREVIATION: C03150
is: HMDB00855
initial concentration: 1.0
is: CHEBI:15927
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_146e8dcc_b24b_41ae_a240_909e83bc89a5
is encoded by: hsa:4706
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: NDUFAB1
is: O14561
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_43fe61ce_6925_4f64_947f_911c20dc224e
is encoded by: hsa:1593
boundary condition: true
is: Q02318
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
name: CYP27A1

metaR sink c101coa LPAREN c RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C101COASINK
type: Reaction

metaR NDPK9
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
name: nucleoside-diphosphate kinase (ATP:IDP)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
reactant: MODEL1310110052#
product: MODEL1310110052#
fast: false
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#

metaR KYNATESYN
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
reactant: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
reversible: false
type: Reaction
is: SBO:0000176
product: MODEL1310110052#
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
is described by: ECO:0000000

metaR CMPACNAtn
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false
name: CMP-Sia nuclear export
is: SBO:0000185
kinetic law: MODEL1310110052#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_41313f99_2713_4989_bb14_ed01572c6a8d
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:84532
type: Species
constant: false
is: Q9NUB1
name: ACSS1
initial amount: NaN

metaM docohexcoa m
name: 2,4,7,10,13,16-docosahexenoylcoa
has only substance units: false
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_4139f50c_d5e8_467a_b3dc_32c1dfa5f455
initial concentration: NaN
type: Species
constant: false
boundary condition: true
name: SLC26A2
initial amount: NaN
is encoded by: hsa:1836
is: P50443
is: SBO:0000252
has only substance units: false

metaR FUMTSULtm
name: Fumarate:thiosulfate antiport, mitochondrial
type: Reaction
reactant: MODEL1310110052#
reversible: true
modifier: MODEL1310110052#
is: SBO:0000185
kinetic law: MODEL1310110052#
is described by: ECO:0000269
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false

metaM ser L e
type: Species
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
initial amount: NaN
constant: false
name: L-serine
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00187
is: CHEBI:17115
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_3f47d919_bc07_4594_b03a_a70933223ea3
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
boundary condition: true
name: B3GNTL1
has only substance units: false
is: Q67FW5
is: SBO:0000252
is encoded by: hsa:146712

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_07433b99_0309_4853_9f1d_73499a1495b4
name: ETFDH
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2110
boundary condition: true
is: Q16134
type: Species
initial amount: NaN

metaM pnto R c
name: (R)-Pantothenate
initial amount: NaN
boundary condition: false
is: CHEBI:7916
has only substance units: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
type: Species
is: SBO:0000247
constant: false
is: HMDB00210
initial concentration: 1.0

metaR EX caro LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Carotene exchange
type: Reaction

metaM ptdcacoa m
name: pentadecanoyl Coenzyme A
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
constant: false
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
has only substance units: false
is: HMDB06499

metaR r0522
reversible: false
fast: false
kinetic law: MODEL1310110052#
product: MODEL1310110052#
modifier: MODEL1310110052#
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
reactant: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
is: SBO:0000176
type: Reaction

metaR ICDHy
reversible: false
notes: GENE_ASSOCIATION: (3417.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES:Two reactions (ICDH1 and ICDH2) for isocitrate dehydrogenase
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42
fast: false
product: MODEL1310110052#
name: isocitrate dehydrogenase (NADP)
is: SBO:0000176
kinetic law: MODEL1310110052#
is described by: ECO:0000269
reactant: MODEL1310110052#
modifier: MODEL1310110052#

metaM g1m8mpdol L r
type: Species
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
notes: FORMULA: C1840H3028N20O670P20 CHARGE: -20
is: C05870
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false

metaR RDH1a
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.300
reversible: true
product: MODEL1310110052#
modifier: MODEL1310110052#
name: retinol dehydrogenase (all-trans,NADPH)
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.105
fast: false
reactant: MODEL1310110052#
is described by: ECO:0000269
kinetic law: MODEL1310110052#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_9ec3bded_e59b_44e2_87a3_550da770cd1d
initial concentration: NaN
constant: false
is: P05496
is encoded by: hsa:516
name: ATP5G1
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR RE1527M
reactant: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#
type: Reaction
fast: false
modifier: MODEL1310110052#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1527
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
reversible: true
kinetic law: MODEL1310110052#

metaR C102CPT1
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decadienoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_651cb9bb_f989_4750_9a7a_11bef6248b39
has only substance units: false
initial concentration: NaN
is: Q9HCC0
name: MCCC2
constant: false
is encoded by: hsa:64087
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species

metaM CE2416 x
name: (2R,6S,10S)-pristanate
type: Species
initial concentration: 1.0
is: CHEBI:57923
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)/p-1/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: CE2416
initial amount: NaN
is: SBO:0000247

metaR INSTt4 2
type: Reaction
is: SBO:0000185
reactant: MODEL1310110052#
name: inositol transport via sodium symport
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
fast: false
reversible: true
product: MODEL1310110052#
modifier: MODEL1310110052#
is described by: ECO:0000006
kinetic law: MODEL1310110052#

metaR NAGLCAly
type: Reaction
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: false
name: N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
product: MODEL1310110052#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110052#_95cb1ad8_d7d6_4ab2_9d37_9044fe20ed5e
type: Species
boundary condition: true
name: SULT1A1
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:6817
initial amount: NaN

metaR r1641
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110052#
reactant: MODEL1310110052#
is: SBO:0000185

metaR r0523
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
is version of: http://identifiers.org/ec-code/1.17.4.1
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
is described by: ECO:0000000
modifier: MODEL1310110052#
reversible: false

metaR FATP7t
is described by: ECO:0000000
modifier: MODEL1310110052#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.7
fast: false
name: fatty acid electroneutral transport
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110052#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110052#
product: MODEL1310110052#

metaM ser L c
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
constant: false
has only substance units: false
name: L-serine
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17115
type: Species
is: HMDB00187
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_fff273ab_e85a_423e_8cbf_2cd72f50f80e
is encoded by: hsa:8659
type: Species
name: ALDH4A1
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR MM7B2g
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
is: SBO:0000176
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.113
product: MODEL1310110052#

metaR CYTK6n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110052#
name: cytidylate kinase (CMP,CTP),nuclear
fast: false
reactant: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM 3octpencoa m
initial concentration: 1.0
name: 3,6,9,12,15-octadecapentenoylcoa
boundary condition: false
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/5280355
initial amount: NaN
type: Species
is: SBO:0000247

metaR GGH 6DHFe
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
name: Gamma-glutamyl hydrolase (6DHF), extracellular
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110052#_ac85440e_6ff1_4398_8dc5_b38fc3795fdb
name: DPM3
type: Species
is encoded by: hsa:54344
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q9P2X0

metaR DHCRD1
name: dihydroceramide desaturase
modifier: MODEL1310110052#
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
is described by: ECO:0000269
product: MODEL1310110052#
reversible: false

metaM glu L c
is: SBO:0000247
is: CHEBI:29985
initial amount: NaN
is: HMDB00148
boundary condition: false
type: Species
has only substance units: false
name: L-glutamate(1-)
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial concentration: 1.0
constant: false

metaR PUNP7
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Xanthosine)
is: SBO:0000176
reversible: true
modifier: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110052#
product: MODEL1310110052#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_8ce6672b_8565_421c_b9fb_1f105e77e12f
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:83697
constant: false
initial concentration: NaN
name: SLC4A9
is: E9PDK1

metaR r1640
is described by: ECO:0000000
reactant: MODEL1310110052#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaR S6T14g
is: SBO:0000176
reversible: false
product: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110052#

metaM apoC m
type: Species
is: HMDB00182
constant: false
name: Apocarboxlase (no lys residue)
initial amount: NaN
is: CHEBI:32551
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: XH CHARGE: 0
has only substance units: false

metaM succ e
is: HMDB00254
constant: false
name: succinate(2-)
initial amount: NaN
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:30031
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_3847c2eb_be97_42b8_a738_78ae3e99c5db
boundary condition: true
is encoded by: hsa:11001
is: O14975
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
name: SLC27A2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_f6a48468_a708_4a38_857f_ae8f1eb4f788
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:686
is: SBO:0000252
is: P43251
name: BTD
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_d4f32d76_95c5_4fd1_8d48_abcd30f400e1
constant: false
is: P06576
name: ATP5B
has only substance units: false
is encoded by: hsa:506
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM ksi deg8 l
is: SBO:0000247
name: keratan sulfate I, degradation product 8
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
is: CHEBI:12936
is: HMDB00143
constant: false
boundary condition: false
has only substance units: false

metaM na1 r
constant: false
name: sodium(1+)
is: HMDB00588
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
initial amount: NaN
boundary condition: false
is: CHEBI:29101
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species

metaM 2mop c
boundary condition: false
type: Species
is: HMDB01172
is: CHEBI:57700
is: SBO:0000247
name: 2-methyl-3-oxopropanoate
initial concentration: 1.0
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
has only substance units: false
initial amount: NaN

metaR AHEXASE2ly
fast: false
reactant: MODEL1310110052#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
modifier: MODEL1310110052#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.2.1.52

metaM oxa c
name: oxalate(2-)
boundary condition: false
constant: false
is: CHEBI:30623
is: SBO:0000247
is: HMDB02329
initial concentration: 1.0
type: Species
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_c1b33642_0d50_4f06_9264_fe7dd6cbdde0
constant: false
initial concentration: NaN
is encoded by: hsa:8801
type: Species
is: SBO:0000252
is: Q96I99
has only substance units: false
name: SUCLG2
initial amount: NaN
boundary condition: true

metaR SIAASE3ly
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
name: sialidase, lysosomal
fast: false
kinetic law: MODEL1310110052#
is described by: ECO:0000000
modifier: MODEL1310110052#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23

http://identifiers.org/biomodels.db/MODEL1310110052#_e28b5afc_cd6f_4a7f_94dd_664a85b734b2
has only substance units: false
name: ECHS1
is: P30084
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1892
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_16a29be7_b23f_49cc_94a8_fa2e32e1fe26
has only substance units: false
is encoded by: hsa:3636
initial concentration: NaN
name: INPPL1
boundary condition: true
is: SBO:0000252
is: O15357
type: Species
constant: false
initial amount: NaN

metaR 3MOBte
name: Transport of 3-methyl-2-oxobutanoate
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
reversible: true
product: MODEL1310110052#
type: Reaction
fast: false

metaR GLUt2m
reversible: true
notes: GENE_ASSOCIATION: (83733.1) or (8604.1) or (79751.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
modifier: MODEL1310110052#
reactant: MODEL1310110052#
product: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
name: L-glutamate reversible transport via proton symport, mitochondrial

metaR DPPS
reversible: false
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
type: Reaction
fast: false
name: decaprenyl synthase
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 2 AUTHORS: PMID:16262699 NOTES:by analogy to other dimethyl transferase rxns. See PMID: 10586494, human interemidate (from C15 ->C50) not explicitly determined yet, however it is known to occur since this pathway is essential in Q10 synthesis. For human metabolism: may be associated w/ GeneID: 23590 TPRT - recheck lit in future IT and NJ
product: MODEL1310110052#

metaR TYMSFt
is: SBO:0000185
reactant: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
kinetic law: MODEL1310110052#
is described by: ECO:0000000
fast: false
name: Tyramine O-sulfate transport (diffusion)
reversible: false
product: MODEL1310110052#

metaR EX tettet6 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosatetraenoic acid n-6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_1e6e194a_7682_46e0_b704_c31f3e395d51
name: GBA
type: Species
initial concentration: NaN
is encoded by: hsa:2629
is: B7Z6S1
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252

metaR GCCam
is version of: http://identifiers.org/ec-code/1.8.1.4
type: Reaction
kinetic law: MODEL1310110052#
product: MODEL1310110052#
name: glycine-cleavage complex (lipoylprotein), mitochondrial
is: SBO:0000176
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.1.2.10
fast: false
is version of: http://identifiers.org/ec-code/1.4.4.2
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD

metaR RIBt
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
type: Reaction
reversible: true
name: ribose transport via diffusion
reactant: MODEL1310110052#
product: MODEL1310110052#

metaR H2CO3D
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.1
reversible: true
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
fast: false
modifier: MODEL1310110052#
is: SBO:0000176
reactant: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#
name: carboxylic acid dissociation
product: MODEL1310110052#

metaR RE2269E
fast: false
reactant: MODEL1310110052#
name: RE2269
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
is version of: http://identifiers.org/ec-code/3.4.21.39
type: Reaction
reversible: true
modifier: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000000
kinetic law: MODEL1310110052#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110052#_81a5335b_d341_4bf2_a884_d4cc352989bd
has only substance units: false
name: UROC1
is: Q68CJ7
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:131669
constant: false

metaM zymst r
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
constant: false
initial amount: NaN
is: HMDB06271
is: CHEBI:18252
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
name: zymosterol

metaM c4dc x
name: succinyl carnitine
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/213144
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C11H18NO6 CHARGE: -1
is: C02862
is: HMDB02013
type: Species

metaR BACCL
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
fast: false
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110052#
name: biotin-[acetyl-CoA-carboxylase] ligase
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/6.3.4.10

metaM rib D c
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: HMDB00283
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:16988
name: D-ribose
type: Species

metaM 3tetd7ecoacrn e
type: Species
name: 3-hydroxy tetradecenoyl-7-carnitine
is: SBO:0000247
notes: FORMULA: C21H39NO5 CHARGE: 0
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB02014

metaR C6COAt
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of of hexanoylcoa for transport into cytosol
type: Reaction

metaR RE1526M
type: Reaction
reversible: true
reactant: MODEL1310110052#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1526
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
product: MODEL1310110052#
modifier: MODEL1310110052#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_c05f731f_d07e_46fd_bc7f_8a6ac618e4f6
constant: false
type: Species
boundary condition: true
name: PI4K2A
is encoded by: hsa:55361
has only substance units: false
is: Q9BTU6
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110052#_f627f7c5_3618_482e_93ca_0d960708d275
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:29929
name: ALG6
has only substance units: false
constant: false
is: Q9Y672
type: Species
initial concentration: NaN

metaM CE2705 c
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
name: quinonoid dihydrobiopterin
initial amount: NaN
is: CHEBI:36781
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false

metaM creat c
has only substance units: false
is: HMDB00064
boundary condition: false
is: SBO:0000247
name: creatine
type: Species
initial amount: NaN
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: CHEBI:16919
constant: false
initial concentration: 1.0

metaM HC01406 m
is: CHEBI:28264
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
name: 3-Oxooctanoyl-CoA
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_35190889_3f8a_4e02_b3d7_a09bd23d1514
is encoded by: hsa:5321
constant: false
name: PLA2G4A
boundary condition: true
type: Species
has only substance units: false
is: P47712
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM dhbpt c
type: Species
boundary condition: false
is: CHEBI:20680
initial concentration: 1.0
name: 6,7-dihydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00038

metaR LNLCCRNt
fast: false
type: Reaction
product: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110052#
name: transport into the mitochondria (carnitine)
reactant: MODEL1310110052#
is: SBO:0000185
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110052#_18b06786_04fc_4b49_a320_b7c47bffebe6
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:84812
name: PLCD4
type: Species
is: SBO:0000252
is: Q9BRC7
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_e02ca975_9d33_497c_9ae7_9b5658a53294
has part: P23921
has only substance units: false
is: SBO:0000297
is encoded by: hsa:6240
initial amount: NaN
type: Species
is encoded by: hsa:6241
has part: P31350
name: RRM1:RRM2
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_f6057e4e_13b1_4193_8267_5a263f75479a
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
name: ACSL1
is encoded by: hsa:2180
has only substance units: false
initial amount: NaN
is: P33121

http://identifiers.org/biomodels.db/MODEL1310110052#_535076ec_38b2_4151_834d_40940f29f1e1
initial amount: NaN
boundary condition: true
name: CDO1
initial concentration: NaN
is encoded by: hsa:1036
has only substance units: false
is: SBO:0000252
constant: false
is: Q16878
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_9e456d6f_5b8d_4896_9d96_920e9065ec69
initial concentration: NaN
type: Species
boundary condition: true
name: CA14
constant: false
is: A8K3J4
is encoded by: hsa:23632
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM 34dhphe c
type: Species
name: L-dopa
is: CHEBI:15765
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
is: HMDB00181
initial concentration: 1.0
initial amount: NaN

metaM rib D e
is: HMDB00283
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
name: D-ribose
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:16988
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false

metaR RE2799C
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110052#
is: SBO:0000176
name: RE2799
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000

metaR EX tetpent3 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-3 exchange
type: Reaction

metaM ksi deg35 l
constant: false
is: CHEBI:12936
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00143
is: SBO:0000247
boundary condition: false
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
name: keratan sulfate I, degradation product 35

http://identifiers.org/biomodels.db/MODEL1310110052#_5c612e9a_5722_4c97_8d2a_6756772458d9
type: Species
constant: false
is encoded by: hsa:5152
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: PDE9A
initial concentration: NaN
has only substance units: false

metaR NDPK1
type: Reaction
reversible: true
fast: false
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:GDP)
is described by: ECO:0000134
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110052#
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_119a4e3f_2849_4a78_ae31_5bb826d577bb
name: SLC33A1
is encoded by: hsa:9197
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: O00400
has only substance units: false

metaR r1646
kinetic law: MODEL1310110052#
reversible: true
reactant: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110052#
type: Reaction
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR r0954
product: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17180682 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
name: MCT 1 Transport reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_9681190b_e0fe_4df2_9497_009e0dc1777f
initial amount: NaN
is: SBO:0000252
is: Q9Y4K0
type: Species
name: LOXL2
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:4017
initial concentration: NaN

metaR r0841
product: MODEL1310110052#
name: Free diffusion
modifier: MODEL1310110052#
is: SBO:0000185
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.1.1.271
reactant: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
reversible: true
is described by: ECO:0000000
fast: false

metaR EX ddecrn
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lauroyl carnitine
type: Reaction

metaR GALASE7ly
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110052#
reversible: false
kinetic law: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110052#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
reactant: MODEL1310110052#
type: Reaction

metaR RE1233C
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
name: RE1233
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
modifier: MODEL1310110052#
is: SBO:0000176
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.6.1.64
type: Reaction
fast: false

metaM ser L m
is: CHEBI:17115
initial amount: NaN
initial concentration: 1.0
is: HMDB00187
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
constant: false
name: L-serine

http://identifiers.org/biomodels.db/MODEL1310110052#_3baa7292_5aa5_4e38_bf95_db52796a53b1
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:6888
name: TALDO1
is: P37837
type: Species

metaM creat e
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: CHEBI:16919
has only substance units: false
type: Species
is: HMDB00064
name: creatine
is: SBO:0000247

metaM 34dhphe e
initial concentration: 1.0
is: CHEBI:15765
name: L-dopa
is: HMDB00181
is: SBO:0000247
constant: false
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species

metaR PTDCACRNt
is: SBO:0000185
name: pentadecanoate transport into the mitochondria
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110052#
product: MODEL1310110052#
modifier: MODEL1310110052#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110052#_f682b11e_3566_4995_90d6_24800425a296
name: ST3GAL5
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8869
is: Q9UNP4
initial concentration: NaN
initial amount: NaN
type: Species
constant: false

metaR NDPK4n
is described by: ECO:0000304
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110052#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#

metaR PRISTCOAtcx
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

metaR r1647
fast: false
is described by: ECO:0000000
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110052#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reversible: true

metaM c12dccoa x
initial amount: NaN
boundary condition: false
is: HMDB03712
constant: false
type: Species
has only substance units: false
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
name: dodecanedioylcoa
is: SBO:0000247
initial concentration: 1.0

metaM 3hdeccoa m
type: Species
is: HMDB02288
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
name: 3-hydroxyhexadecenoylcoa
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_61eec050_dd35_4ba5_b2e3_faae3be80e17
initial amount: NaN
is encoded by: hsa:514
type: Species
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is: SBO:0000297
is encoded by: hsa:509
initial concentration: NaN
has part: P56381
has part: P36542
has part: P30049
has only substance units: false
boundary condition: true
has part: P06576
is encoded by: hsa:498
is encoded by: hsa:506
has part: A8K092
constant: false
is encoded by: hsa:513

metaM oxa e
is: CHEBI:30623
has only substance units: false
constant: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB02329
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
name: oxalate(2-)

metaM digalside hs l
initial concentration: 1.0
is: C06126
is: http://identifiers.org/pubchem.compound/8383
constant: false
boundary condition: false
type: Species
is: SBO:0000247
name: Digalactosylceramide
initial amount: NaN
has only substance units: false
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126

metaR PTE4x
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.1.2.2
name: peroxisomal acyl-CoA thioesterase
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
fast: false
reversible: false
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_d7f378e9_14e6_4fca_a3bb_f2db24fad107
name: GGT2
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:728441
initial concentration: NaN
boundary condition: true

metaR SUCD1m
type: Reaction
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.3.5.1
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
name: succinate dehydrogenase
fast: false
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
reversible: true
modifier: MODEL1310110052#

metaM cs b deg2 l
is: HMDB01354
initial amount: NaN
is: CHEBI:57455
notes: FORMULA: C37H54NO41S3 CHARGE: -5
boundary condition: false
has only substance units: false
type: Species
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR NDPK4
is described by: ECO:0000269
product: MODEL1310110052#
name: nucleoside-diphosphate kinase (ATP:dTDP)
modifier: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is: SBO:0000176

metaR DDECE1CRNe
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of dodecenoyl carnitine into extra cellular space
type: Reaction

metaM paf hs e
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
has only substance units: false
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
is: CHEBI:36707
constant: false
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_0ec9f3ed_a740_466d_ae2a_9103bd7fa7cb
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:218
boundary condition: true
is: P30838
has only substance units: false
constant: false
initial amount: NaN
name: ALDH3A1

metaM 2dodtricoa m
is: SBO:0000247
has only substance units: false
is: HMDB03952
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: C05280
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
name: 2,6,9-dodecatrienoylcoa
initial amount: NaN

metaR r1648
reactant: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110052#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110052#
fast: false
modifier: MODEL1310110052#
type: Reaction
reversible: true
is: SBO:0000185

metaM fe2 c
boundary condition: false
has only substance units: false
type: Species
is: HMDB00692
initial amount: NaN
name: Fe2+
constant: false
is: C00023
initial concentration: 1.0
is: CHEBI:29033
is: SBO:0000247
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaM HC01410 m
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:28706
is: SBO:0000247
constant: false
name: (2E)-Hexenoyl-CoA
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271

metaR NDPK2
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reactant: MODEL1310110052#
name: nucleoside-diphosphate kinase (ATP:UDP)
modifier: MODEL1310110052#
fast: false
type: Reaction
kinetic law: MODEL1310110052#
product: MODEL1310110052#

metaR NDPK3
name: nucleoside-diphosphate kinase (ATP:CDP)
type: Reaction
reversible: true
is: SBO:0000176
fast: false
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110052#
is described by: ECO:0000269
product: MODEL1310110052#

metaM glyc3p x
is: C00093
initial concentration: 1.0
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
has only substance units: false
initial amount: NaN
is: HMDB00126
is: SBO:0000247
boundary condition: false
is: CHEBI:57597
constant: false
type: Species
name: Glycerol 3-phosphate

metaR CYSSNAT5tc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR r1649
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110052#
reversible: true

metaR HMGCOAtx
reversible: true
product: MODEL1310110052#
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
fast: false
is described by: ECO:0000000
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
kinetic law: MODEL1310110052#
type: Reaction
is: SBO:0000185

metaM dhcholestancoa r
is: HMDB02159
type: Species
boundary condition: false
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
is: CHEBI:15494
has only substance units: false

metaR r0842
reversible: true
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
name: Postulated transport reaction
is version of: http://identifiers.org/ec-code/1.3.1.72
fast: false
modifier: MODEL1310110052#
type: Reaction
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaR METS
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110052#
name: methionine synthase
reversible: false
product: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (4548.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.1.1.13 Confidence Level: 4 AUTHORS: PMID:8968736,PMID:9013615 NOTES:Human Y/N: Y
is described by: ECO:0000134
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.1.1.13

metaR NACHEXA20ly
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110052#
fast: false
product: MODEL1310110052#
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
type: Reaction
reversible: false
name: beta-N-acetylhexosaminidase A, lysosomal
kinetic law: MODEL1310110052#
is described by: ECO:0000000
is: SBO:0000176

metaM thr L c
is: HMDB00167
name: L-threonine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:16857
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR FAOXC226205m
modifier: MODEL1310110052#
type: Reaction
name: Beta oxidation of long chain fatty acid
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_369b950a_4bdf_4d04_bc1b_d078750a82db
name: PIGW
constant: false
type: Species
is: Q7Z7B1
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:284098
is: SBO:0000252
initial concentration: NaN

metaM ha e
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:16336
name: hyaluronan
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_85edea41_6569_4b54_b12b_c90d2b452a4e
type: Species
has only substance units: false
name: ACOX1
is encoded by: hsa:51
is: B4DK61
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false

metaM l2n2m2mn l
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
is: SBO:0000247
is: CHEBI:12936
initial amount: NaN
is: HMDB00143
has only substance units: false
constant: false
notes: FORMULA: C54H91N3O41 CHARGE: 0
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110052#_af3df66f_1a6b_462d_a91b_8c4af0dc8765
has part: H0UI06
has part: Q6FGA0
is encoded by: hsa:1347
type: Species
has part: Q96KJ9
is encoded by: hsa:9377
is: SBO:0000297
is encoded by: hsa:125965
is encoded by: hsa:1345
is encoded by: hsa:1350
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: P24310
is encoded by: hsa:4512
has part: Q02221
has only substance units: false
is encoded by: hsa:170712
is encoded by: hsa:1349
has part: Q7GXZ8
is encoded by: hsa:1337
is encoded by: hsa:9167
is encoded by: hsa:1340
has part: P20674
has part: Q8TF08
is encoded by: hsa:4514
has part: Q6YFQ2
has part: P13073
is encoded by: hsa:1339
has part: Q7GXY8
is encoded by: hsa:1327
initial concentration: NaN
has part: Q53YB7
has part: Q7Z4L0
has part: P24311
is encoded by: hsa:1329
constant: false
is encoded by: hsa:1351
is encoded by: hsa:1346
has part: Q53XN1
has part: P12074
boundary condition: true
is encoded by: hsa:4513
has part: P14854
has part: P09669
has part: P15954
initial amount: NaN
is encoded by: hsa:341947
is encoded by: hsa:84701
has part: P00414

http://identifiers.org/biomodels.db/MODEL1310110052#_43083d30_0e2f_4e08_8830_9f9daa633725
boundary condition: true
constant: false
is encoded by: hsa:570
has only substance units: false
initial amount: NaN
is: Q14032
initial concentration: NaN
type: Species
is: SBO:0000252
name: BAAT

metaR G14T12g
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
reversible: false
is: SBO:0000176
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38

metaM 2mop m
is: HMDB01172
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
boundary condition: false
is: CHEBI:57700
name: 2-methyl-3-oxopropanoate
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false

metaM biocyt m
boundary condition: false
has only substance units: false
is: SBO:0000247
is: C05552
type: Species
initial amount: NaN
is: HMDB03134
name: Biocytin
is: http://identifiers.org/pubchem.compound/7886
constant: false
initial concentration: 1.0
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552

metaM cmpacna g
initial amount: NaN
is: CHEBI:57812
constant: false
is: HMDB01176
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: SBO:0000247
initial concentration: 1.0
name: CMP-N-acetyl-beta-neuraminate(2-)

http://identifiers.org/biomodels.db/MODEL1310110052#_10942fa3_0433_47ae_8942_5f65e9c58013
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q9UHV8
is: SBO:0000252
is encoded by: hsa:29124
name: LGALS13
constant: false
initial amount: NaN
type: Species

metaR DSREDUCr
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
modifier: MODEL1310110052#
type: Reaction
is: SBO:0000176
product: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
reversible: false
name: Desmosterol reductase
is version of: http://identifiers.org/ec-code/1.3.1.72
kinetic law: MODEL1310110052#

metaM hxcoa c
type: Species
name: Hexanoyl-CoA (n-C6:0CoA)
has only substance units: false
is: HMDB13130
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_e03689eb_fc49_430b_a5c6_1c9e8fe6ad5b
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: AHCYL1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10768

metaR MALSO4tm
is described by: ECO:0000269
product: MODEL1310110052#
name: Malate:sulfate antiport, mitochondrial
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_b63f4b73_0b35_4bfd_bac1_141f2b4abe0f
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: P34949
constant: false
boundary condition: true
name: MPI
type: Species
is encoded by: hsa:4351

http://identifiers.org/biomodels.db/MODEL1310110052#_beabfd9f_c84a_4099_ba48_64078820c264
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q02318
constant: false
is encoded by: hsa:1593
type: Species
name: CYP27A1

http://identifiers.org/biomodels.db/MODEL1310110052#_eb3fafe8_776c_4e8f_8e4f_6401918ed16e
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110052#_69ffb563_11f8_4c5c_b075_9a686fd09b70
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
name: GSTZ1
initial amount: NaN
has only substance units: false
is encoded by: hsa:2954

metaM dctp c
is: HMDB00998
has only substance units: false
is: SBO:0000247
boundary condition: false
name: dCTP
is: C00458
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: CHEBI:16311

http://identifiers.org/biomodels.db/MODEL1310110052#_44a196b1_ec6c_4eb7_8d7c_fb0d0cda4b5a
constant: false
has only substance units: false
boundary condition: true
name: MIA3
is: Q5JRA6
type: Species
is encoded by: hsa:375056
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM 4nphsf c
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
is: HMDB06492
type: Species
is: SBO:0000247
name: 4-Nitrophenyl sulfate
is: CHEBI:35422
constant: false
initial concentration: 1.0
has only substance units: false

metaM na1 e
constant: false
boundary condition: false
name: Sodium
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: Na CHARGE: 1
is: HMDB00588
has only substance units: false
is: CHEBI:4541
is: C01330
type: Species

metaR r1757
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110052#
product: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
name: Y+LAT2 Utilized transport
is: SBO:0000185
reversible: false

metaR FAOXC5OHc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: (3-hydroxyisovalerylcoa-->3-hydroxyisovalerylcarnitine)c
type: Reaction

metaR GUAt
product: MODEL1310110052#
name: Guanine transport
type: Reaction
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
reversible: true
kinetic law: MODEL1310110052#
is: SBO:0000185
modifier: MODEL1310110052#
reactant: MODEL1310110052#

metaR NACHEX21ly
is described by: ECO:0000000
product: MODEL1310110052#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: false

metaR HACD9m
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
reactant: MODEL1310110052#
fast: false
type: Reaction
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000134
product: MODEL1310110052#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110052#_f077b203_14a2_4461_b427_02760d06a72d
initial amount: NaN
is: Q53FV7
is encoded by: hsa:1375
constant: false
name: CPT1B
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true

metaM adp r
is: SBO:0000247
name: ADP(3-)
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
boundary condition: false
is: CHEBI:456216
is: HMDB01341
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_61f99fed_60e5_47ec_9a62_f60fd5baaf61
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
is: P09972
type: Species
boundary condition: true
is encoded by: hsa:230
name: ALDOC

http://identifiers.org/biomodels.db/MODEL1310110052#_42bb59a4_315a_4221_8203_c13cd3884625
type: Species
initial concentration: NaN
is: B7Z763
constant: false
name: AMPD3
is encoded by: hsa:272
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR HMGCOAtm
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110052#
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
type: Reaction
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_42b7e2b6_70e7_4996_8303_22e27559c373
initial amount: NaN
name: ATP5I
type: Species
is: P56385
is encoded by: hsa:521
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR CHSTEROLt1
fast: false
modifier: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
reversible: true
reactant: MODEL1310110052#
is described by: ECO:0000304
name: cholesterol intracellular transport
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
is: SBO:0000185
kinetic law: MODEL1310110052#

metaR NDP7g
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.6
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
reversible: false
reactant: MODEL1310110052#
name: nucleoside-diphosphatase (UDP), Golgi apparatus
type: Reaction
fast: false
product: MODEL1310110052#
is described by: ECO:0000269
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#

metaR DHDPBMTm
type: Reaction
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.1.1.114
is: SBO:0000176
fast: false
modifier: MODEL1310110052#
reversible: false
product: MODEL1310110052#
name: dihydroxydecaprenylbenzoate methyltransferase
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: 2.1.1.114 Confidence Level: 4 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.1.1.114 IT
kinetic law: MODEL1310110052#
is described by: ECO:0000269

metaR RE1533M
name: RE1533
reactant: MODEL1310110052#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
modifier: MODEL1310110052#
is: SBO:0000176
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_1c510cc3_d752_427e_be77_33418ae1dfd6
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
name: MUT
is encoded by: hsa:4594
is: P22033

metaR RE3347C
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
name: RE3347
product: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
reversible: true

metaR LTA4H
product: MODEL1310110052#
type: Reaction
modifier: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
is described by: ECO:0000134
reversible: false
name: Leukotriene A-4 hydrolase
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.3.2.6
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110052#_17b8bb77_0585_42c7_b869_6363e40beffa
is: P18283
initial amount: NaN
is encoded by: hsa:2877
name: GPX2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_1e5372fd_e89b_429c_86d3_8de66425611c
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6579
boundary condition: true
is: P46721
type: Species
has only substance units: false
constant: false
name: SLCO1A2

metaR ADK1m
modifier: MODEL1310110052#
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
reversible: true
type: Reaction
kinetic law: MODEL1310110052#
fast: false
product: MODEL1310110052#
is described by: ECO:0000269
name: adenylate kinase, mitochondrial
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110052#_cb851a9c_1465_4798_89d3_013a60ce4d90
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:AA278423
name: _AA278423_1_m
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_11086149_e917_41ec_a7ba_578c92d9d759
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:1583
has only substance units: false
boundary condition: true
initial concentration: NaN
is: G3XAD7
name: CYP11A1
is: SBO:0000252

metaM na1 c
initial concentration: 1.0
is: HMDB00588
name: Sodium
notes: FORMULA: Na CHARGE: 1
is: C01330
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: CHEBI:4541

metaR CHSTEROLt2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is described by: ECO:0000000
name: cholesterol intracellular transport
is: SBO:0000185
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_a8db3e75_5ad4_4182_821f_a3bea858710c
initial concentration: NaN
boundary condition: true
name: GLUL
initial amount: NaN
is: P15104
is: SBO:0000252
type: Species
is encoded by: hsa:2752
has only substance units: false
constant: false

metaR ETFQO
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110052#
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
reversible: false
modifier: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.5.1
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977

metaR HXPRT
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.4.2.8
type: Reaction
fast: false
modifier: MODEL1310110052#
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
reactant: MODEL1310110052#
is described by: ECO:0000269
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110052#_80ad8afc_52ec_4155_8565_ac84083fad39
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2542
type: Species
initial amount: NaN
is: A8K0S7
constant: false
name: SLC37A4
boundary condition: true

metaM 4nphsf e
initial amount: NaN
name: 4-Nitrophenyl sulfate
is: SBO:0000247
is: CHEBI:35422
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB06492
constant: false
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
boundary condition: false

metaM adp x
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:456216
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
type: Species
is: HMDB01341
name: ADP(3-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_b16bccc9_acf5_49f9_90b2_35afcca7bb0f
has only substance units: false
name: PANK4
boundary condition: true
is encoded by: hsa:55229
is: Q9NVE7
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
initial amount: NaN

metaR MMMm
is: SBO:0000176
kinetic law: MODEL1310110052#
is described by: ECO:0000269
reactant: MODEL1310110052#
fast: false
product: MODEL1310110052#
name: methylmalonyl-CoA mutase
reversible: true
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.99.2
modifier: MODEL1310110052#

metaM 3tetd7ecoacrn c
notes: FORMULA: C21H39NO5 CHARGE: 0
type: Species
constant: false
initial amount: NaN
name: 3-hydroxy tetradecenoyl-7-carnitine
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB02014

http://identifiers.org/biomodels.db/MODEL1310110052#_cabfc92c_d8d5_4fb2_a41a_e6056962d350
initial amount: NaN
name: PI4KA
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5297
type: Species
constant: false
has only substance units: false
boundary condition: true
is: B4DYG5

http://identifiers.org/biomodels.db/MODEL1310110052#_82242711_7d02_4015_836d_3ca986fd81d1
is encoded by: hsa:2109
boundary condition: true
initial concentration: NaN
is: SBO:0000297
name: ETFA:ETFB
is encoded by: hsa:2108
type: Species
constant: false
has only substance units: false
has part: P13804
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_42c49b97_29fd_4717_901a_0084d571416f
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: _AV713053_1_m
initial concentration: NaN
is encoded by: hsa:AV713053
type: Species

metaM betald m
initial amount: NaN
name: betaine aldehyde
constant: false
boundary condition: false
type: Species
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
initial concentration: 1.0
is: HMDB01252
is: SBO:0000247
has only substance units: false
is: CHEBI:15710

metaR Ser Thrtg
kinetic law: MODEL1310110052#
type: Reaction
name: Ser/Thr transport (from golgi to lysosome)
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
product: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
is: SBO:0000185
is described by: ECO:0000269

metaR CHSTEROLt3
fast: false
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
name: cholesterol intracellular transport
is: SBO:0000185
is described by: ECO:0000000

metaM dhcholestancoa x
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
is: SBO:0000247
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
type: Species
initial amount: NaN
is: HMDB02159
is: CHEBI:15494
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

metaR GRTTx
is: SBO:0000176
reactant: MODEL1310110052#
reversible: false
product: MODEL1310110052#
name: geranyltranstransferase
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
fast: false
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.5.1.1
type: Reaction
modifier: MODEL1310110052#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110052#_548955b4_bffe_4368_b260_b27c611167d2
is: Q9H0N5
is: SBO:0000252
name: PCBD2
constant: false
is encoded by: hsa:84105
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN

metaR ARGt4
modifier: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000304
name: L-arginine transport in via sodium symport
type: Reaction
fast: false
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB

metaM 12ppd S c
is: SBO:0000247
is: CHEBI:29002
initial concentration: 1.0
constant: false
has only substance units: false
name: (S)-propane-1,2-diol
initial amount: NaN
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
type: Species
is: HMDB06213
boundary condition: false

metaR S4TASE1ly
modifier: MODEL1310110052#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.12
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is: SBO:0000176
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
product: MODEL1310110052#

metaR r0381
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
reversible: true
type: Reaction
reactant: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110052#
is described by: ECO:0000000
fast: false

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaM btcoa x
has only substance units: false
is: HMDB01088
boundary condition: false
is: C00136
initial concentration: 1.0
name: Butanoyl-CoA
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C25H38N7O17P3S CHARGE: -4
type: Species
constant: false

metaM no c
initial amount: NaN
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
name: Nitric oxide
boundary condition: false
is: CHEBI:16480
is: C00533
initial concentration: 1.0
is: HMDB03378
type: Species
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_70f90f1f_1b77_451c_9780_096ec89b1da9
initial concentration: NaN
constant: false
is encoded by: hsa:6487
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
name: ST3GAL3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_c872c75e_e87f_4c72_8621_2c714030a851
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: Q9HAS3
is encoded by: hsa:64078
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: SLC28A3

metaR CGLYt3 2
is described by: ECO:0000304
product: MODEL1310110052#
reversible: false
reactant: MODEL1310110052#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
modifier: MODEL1310110052#
name: Cys-Gly transport in via proton symport
kinetic law: MODEL1310110052#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110052#_e1f959ff_efe0_47ee_9809_9dc7a2cfb0a5
constant: false
type: Species
initial concentration: NaN
is: Q53XN1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1351
name: COX8A
initial amount: NaN
has only substance units: false

metaR NADPtxu
reactant: MODEL1310110052#
fast: false
reversible: false
name: NADP transporter, peroxisome
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ potential for free H NJ
is described by: ECO:0000000
kinetic law: MODEL1310110052#
product: MODEL1310110052#
type: Reaction

metaM digalside hs c
constant: false
name: Digalactosylceramide
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
type: Species
initial concentration: 1.0
is: C06126
is: http://identifiers.org/pubchem.compound/8383
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR r0410
is: SBO:0000176
type: Reaction
product: MODEL1310110052#
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
is described by: ECO:0000000

metaR DM 4abut LPAREN n RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID: 16643338 NOTES:GABA in the intestine may aid in differentiation and proliferation of epithelial cells. GABA intake by oral administration has been shown to alleviate stress, worry and anxiety and additionally it can also improve human immunity (PMID: 16971751). However the PAT1 transporter located at the apical side of enterocytes have very low affinity for GABA. I have presumed that this oral GABA is used within intestine (unless administered at high very high pharmacological doses, GABA exit from the enterocytes may be mediated by other specifc transporters).
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for 4-Aminobutanoate(n)
type: Reaction

metaR ACOX22x
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 2 AUTHORS: PMID:11181649 NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 analog as per KEGG added NJ
name: acyl-Coenzyme A oxidase 2, branched chain
is: SBO:0000176
reversible: false
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/1.17.99.3
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
is described by: ECO:0000304
type: Reaction

metaM ha l
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:16336
has only substance units: false
boundary condition: false
type: Species
name: hyaluronan
initial amount: NaN

metaM cmpacna n
initial concentration: 1.0
is: HMDB01176
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:57812
boundary condition: false
name: CMP-N-acetyl-beta-neuraminate(2-)
has only substance units: false
type: Species
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128

http://identifiers.org/biomodels.db/MODEL1310110052#_f1daef19_61cf_4b24_9c4b_6eced94ff4c3
is: A8K7W0
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:8875
name: VNN2
type: Species
is: SBO:0000252

metaM cs e deg5 l
boundary condition: false
type: Species
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
initial amount: NaN
notes: FORMULA: C31H47NO35S3 CHARGE: -4
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:57737
is: HMDB00868
is: SBO:0000247

metaM no e
constant: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16480
is: C00533
has only substance units: false
is: HMDB03378
name: Nitric oxide
boundary condition: false
initial amount: NaN
type: Species

metaM ksii core2 pre2 g
is: SBO:0000247
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 2
type: Species
notes: FORMULA: C39H63N3O28X CHARGE: -1
is: C00130
is: HMDB00175
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:58053
constant: false

metaR PItg
reversible: false
fast: false
is: SBO:0000185
reactant: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110052#
name: phosphate transport, Golgi apparatus
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_468ed24f_afbd_4c94_a733_3a98071d84a1
is: P22392
type: Species
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
name: NME2
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4831

metaM malthp e
initial concentration: 1.0
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
is: http://identifiers.org/pubchem.compound/5041
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: C01936
constant: false
name: maltoheptaose

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_36f6e31f_f61d_44a4_9e89_085a41de8c60
is encoded by: hsa:5238
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: PGM3
is: B4DX94
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_b2a0a446_e32e_4aef_a721_df9f9fdbe39e
type: Species
is: O60762
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8813
name: DPM1
boundary condition: true
has only substance units: false

metaR r1051
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
name: Vesicular transport
fast: false
reversible: true
reactant: MODEL1310110052#
is: SBO:0000185
type: Reaction

metaM galgluside hs g
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
is: C00015
is: HMDB00295
name: galactosyl glucosyl ceramide
has only substance units: false
type: Species
is: CHEBI:58223
initial amount: NaN
is: SBO:0000247

metaR RBTt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110052#
is: SBO:0000185
fast: false
reactant: MODEL1310110052#
is described by: ECO:0000000
name: ribitol transport via passive diffusion
reversible: false
type: Reaction
product: MODEL1310110052#

metaM ocdececrn c
initial amount: NaN
boundary condition: false
is: HMDB06351
initial concentration: 1.0
constant: false
has only substance units: false
name: 11-octadecenoyl carnitine
type: Species
notes: FORMULA: C25H47NO4 CHARGE: 0
is: SBO:0000247

metaR SUCCCROT
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of succinyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_3821d6ad_135a_4f7a_ab69_44f3fbc51a12
has only substance units: false
is encoded by: hsa:6184
is: SBO:0000252
initial concentration: NaN
is: P04843
initial amount: NaN
name: RPN1
type: Species
boundary condition: true
constant: false

metaR C161CPT12
is: SBO:0000176
kinetic law: MODEL1310110052#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1375.1) or (1375.2) or (1374.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110052#
modifier: MODEL1310110052#
reversible: false
name: carnitine O-palmitoyltransferase
type: Reaction
reactant: MODEL1310110052#
fast: false

metaM taur c
initial concentration: 1.0
is: HMDB00251
notes: FORMULA: C2H7NO3S CHARGE: 0
constant: false
name: Taurine
type: Species
is: C00245
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:3544
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_ef39aad9_724a_4912_90c7_0bd89aee5704
has only substance units: false
name: GALNT2
constant: false
type: Species
is: Q10471
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2590

metaM 10fthf m
is: CHEBI:57454
initial amount: NaN
name: 10-formyltetrahydrofolate(2-)
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00972
type: Species
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234

http://identifiers.org/biomodels.db/MODEL1310110052#_94c80eca_4c98_4893_ba60_49df751fc857
initial amount: NaN
type: Species
is: SBO:0000252
name: PDE7B
boundary condition: true
has only substance units: false
is encoded by: hsa:27115
constant: false
is: Q9NP56
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_5512c091_60a3_4261_a4da_3d69b99c0882
has only substance units: false
is: Q86U05
initial amount: NaN
is encoded by: hsa:23428
type: Species
name: SLC7A8
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR HDCAtr
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
is: SBO:0000185
name: fatty acid transport via diffusion

metaR 34DHPLACOX
fast: false
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110052#
is: SBO:0000176
modifier: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (218.1) or (222.1) or (220.1) or (221.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
kinetic law: MODEL1310110052#
name: 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase

metaM orn c
initial concentration: 1.0
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: HMDB00214
is: CHEBI:0
constant: false
boundary condition: false
type: Species
is: SBO:0000247
is: C01602
initial amount: NaN
name: Ornithine
has only substance units: false

metaM dhlpro m
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: Dihydrolipolprotein
notes: FORMULA: H2S2X CHARGE: 0 EHMN_ABBREVIATION: C02972
constant: false
is: CHEBI:16194
type: Species

metaR C141CPT1
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecenoylcarnitine
type: Reaction

metaR r1050
name: Vesicular transport
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110052#
is: SBO:0000185
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
product: MODEL1310110052#
reversible: true

metaM fmn e
boundary condition: false
name: FMN
constant: false
is: CHEBI:58210
has only substance units: false
is: SBO:0000247
notes: FORMULA: C17H19N4O9P CHARGE: -2
type: Species
initial amount: NaN
is: C00061
is: HMDB01520
initial concentration: 1.0

metaM tmndnccoa m
is: SBO:0000247
is: HMDB06514
name: timnodonyl coenzyme A
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false

metaM pan4p e
constant: false
is: HMDB01416
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: C01134
boundary condition: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2
name: Pantetheine 4'-phosphate
is: CHEBI:47942

metaR r1789
product: MODEL1310110052#
name: Y+LAT2 Utilized transport
is: SBO:0000185
modifier: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false

metaR SPHS1Ptr
product: MODEL1310110052#
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
reactant: MODEL1310110052#
is described by: ECO:0000000
name: sphingosine-1-phosphate transport
fast: false
reversible: true
is: SBO:0000185
type: Reaction

metaR FAOXC226C227m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

metaR SUCCTD
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_732bf17f_5354_4a30_9d06_82ec35c5ea05
boundary condition: true
name: NDUFB7
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P17568
is encoded by: hsa:4713
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_45682b3f_e32d_46a6_8f8e_fbc88ab00b89
is encoded by: hsa:10449
name: ACAA2
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: P42765

metaM pmtcoa c
name: Palmitoyl-CoA (n-C16:0CoA)
has only substance units: false
constant: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: CHEBI:3454
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01338
is: C00154
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_ce0e6923_6825_41cf_9f37_dbecb43db29f
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
name: PDE4B
is encoded by: hsa:5142
initial amount: NaN
is: Q5TEK5
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_1ee85b5f_592c_4e19_a3b0_feee234689e0
is: SBO:0000252
is encoded by: hsa:1562
has only substance units: false
name: CYP2C18
initial concentration: NaN
boundary condition: true
is: P33260
constant: false
type: Species
initial amount: NaN

metaM orn e
name: Ornithine
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:0
notes: FORMULA: C5H13N2O2 CHARGE: 1
boundary condition: false
type: Species
is: SBO:0000247
is: C01602
initial amount: NaN
is: HMDB00214

http://identifiers.org/biomodels.db/MODEL1310110052#_eb056fc2_38df_46c6_a55c_5fda0fc3d7ed
initial amount: NaN
name: ALOX5
type: Species
is: P09917
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:240

http://identifiers.org/biomodels.db/MODEL1310110052#_d42c6f31_55cb_4f07_a855_4ddf6ec1d73c
is encoded by: hsa:767
is: SBO:0000252
is: P35219
boundary condition: true
name: CA8
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_c872e6e9_be01_4f7a_9696_8430873eccd2
boundary condition: true
is encoded by: hsa:8813
name: DPM3:DPM1:DPM2
constant: false
has part: O94777
is encoded by: hsa:54344
has part: O60762
initial amount: NaN
has only substance units: false
has part: Q86TM7
type: Species
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:8818

metaR GLRASE
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 1.1.1.20 Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
name: glucuronolactone reductase
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
product: MODEL1310110052#
fast: false

metaR NTD10
type: Reaction
reversible: false
modifier: MODEL1310110052#
name: 5'-nucleotidase (XMP)
product: MODEL1310110052#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:15699053 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Rat
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000254

metaM oxa x
has only substance units: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB02329
constant: false
is: CHEBI:30623
name: oxalate(2-)
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_aa9a5868_bb65_484f_a7fe_c126d84b9556
constant: false
is encoded by: hsa:2271
name: FH
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is: P07954
boundary condition: true
initial amount: NaN

metaM 5forthf c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57456
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
constant: false
type: Species
name: 5-Formiminotetrahydrofolate
is: C00664
has only substance units: false
is: HMDB01534

http://identifiers.org/biomodels.db/MODEL1310110052#_7cf3bbd9_c813_4705_b729_e209df236477
constant: false
is encoded by: hsa:7086
is: E7EPA7
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
name: TKT
is: SBO:0000252

metaM fmn c
name: FMN
boundary condition: false
has only substance units: false
is: CHEBI:58210
constant: false
type: Species
is: SBO:0000247
is: C00061
initial amount: NaN
initial concentration: 1.0
is: HMDB01520
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061

metaM so3 c
is: SBO:0000247
has only substance units: false
is: CHEBI:17137
boundary condition: false
constant: false
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: C00094
initial amount: NaN
type: Species
name: Sulfite
is: HMDB00240
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110052#_9b572898_26cc_499f_b115_bfc15fd2841f
is: SBO:0000252
has only substance units: false
is: P23378
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:2731
name: GLDC
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_02b75bf7_b005_45a5_96dc_b70cbe117e74
is: Q9NQ66
is encoded by: hsa:23236
constant: false
name: PLCB1
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_bcb12314_68c3_4d6d_bc3e_c0bc1360acc4
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:43
name: ACHE
has only substance units: false
constant: false
type: Species
initial concentration: NaN

metaR APRGSTRNte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
name: hydroxyprogesterone transport
fast: false
kinetic law: MODEL1310110052#
is described by: ECO:0000000
reactant: MODEL1310110052#
reversible: true
type: Reaction
product: MODEL1310110052#
is: SBO:0000185

metaR PCt
kinetic law: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.3.44
reactant: MODEL1310110052#
fast: false
name: phosphatidylcholine transporter
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110052#
modifier: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ

metaR GLYt7 311 r
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reversible: true
is: SBO:0000185
is described by: ECO:0000006
name: glycine reversible transport via sodium and chloride symport (3:1:1)
reactant: MODEL1310110052#
type: Reaction
fast: false
modifier: MODEL1310110052#

metaR RE3050R
name: RE3050
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110052#_fded509a_7d22_4913_8585_63d4b1261ab4
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
name: _AA788780_1_c
boundary condition: true
has only substance units: false
is encoded by: hsa:AA788780
initial concentration: NaN

metaR GASNASEly
name: glycosylasparaginase, lysosomal
is described by: ECO:0000000
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/3.5.1.26
reversible: false
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110052#
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110052#
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_a7e43320_6a24_436d_a45a_a749b99c3358
name: TAZ
type: Species
is encoded by: hsa:6901
is: Q16635
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_22dd999f_2fc0_4509_b712_d8a6c7b973db
initial concentration: NaN
type: Species
name: PDHX
is: O00330
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:8050
boundary condition: true

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaR CYTK14n
name: cytidylate kinase (dCMP,CTP),nuclear
modifier: MODEL1310110052#
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reversible: true
fast: false
is: SBO:0000176
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_a003baf6_e93a_4afc_ada1_e1846f14ac02
boundary condition: true
is: SBO:0000252
constant: false
name: ALDH3A2
initial concentration: NaN
initial amount: NaN
is: P51648
is encoded by: hsa:224
type: Species
has only substance units: false

metaR FAOXC181C161m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C16:1)m
type: Reaction

metaM tdcoa c
boundary condition: false
is: SBO:0000247
is: C02593
is: CHEBI:57385
name: Tetradecanoyl-CoA (n-C14:0CoA)
initial amount: NaN
is: HMDB01521
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
type: Species
constant: false

metaR r1785
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110052#
product: MODEL1310110052#
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false
reversible: false
reactant: MODEL1310110052#

metaR FAOXC14C12m
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)m
type: Reaction

metaM amet c
is: SBO:0000247
initial concentration: 1.0
name: S-Adenosyl-L-methionine
is: C00019
is: HMDB01185
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:15414
has only substance units: false
constant: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019

metaR EX fuc L LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Fucose exchange
type: Reaction

metaM 2hexdtetcoa m
is: SBO:0000247
is: HMDB02288
name: 2,7,10,13-hexadecatetraenoylcoa
type: Species
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN

metaM dudp c
constant: false
is: C01346
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:60471
name: dUDP
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: HMDB01000

http://identifiers.org/biomodels.db/MODEL1310110052#_850abe64_b297_4236_9007_99bb2fea9d6b
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: E7EML0
name: SLC4A8
is encoded by: hsa:9498
constant: false

metaM 2amac c
type: Species
is: SBO:0000247
name: 2-aminoacrylic acid
boundary condition: false
is: CHEBI:17123
constant: false
has only substance units: false
initial amount: NaN
is: HMDB03609
notes: FORMULA: C3H5NO2 CHARGE: 0 INCHI: InChI=1S/C3H5NO2/c1-2(4)3(5)6/h1,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00906 EHMN_ABBREVIATION: C02218
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110052#_73569a9c_6144_43ab_aeb1_287658402d03
constant: false
has only substance units: false
boundary condition: true
name: PDE9A
is: SBO:0000252
is encoded by: hsa:5152
initial concentration: NaN
initial amount: NaN
type: Species

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_26a2a0c3_d405_458e_9a1c_eb2865dcb8d5
is encoded by: hsa:80308
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: FLAD1
boundary condition: true
initial concentration: NaN

metaM dheas c
initial amount: NaN
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
type: Species
is: HMDB01032
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
boundary condition: false
is: CHEBI:57905
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_537c3645_ca9d_4acd_9e44_165583d88caf
has only substance units: false
type: Species
is: Q6LEN5
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
name: CHAT
is encoded by: hsa:1103
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_9743e93d_4853_4a4b_94b9_7107524a6a04
initial amount: NaN
initial concentration: NaN
name: NOS3
has only substance units: false
is: A0S0A7
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:4846
boundary condition: true

metaR EX 3octdece1crn
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-octadecenoyl carnitine
type: Reaction

metaM dmnoncoa m
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
name: 4,8 dimethylnonanoyl-CoA
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: HMDB11604
boundary condition: false
initial concentration: 1.0

metaM pan4p m
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: CHEBI:47942
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01416
has only substance units: false
name: pantetheine 4'-phosphate(2-)

metaM succoa c
is: HMDB01022
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
name: Succinyl-CoA
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
initial concentration: 1.0
type: Species

metaM xoldiolone r
initial amount: NaN
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
type: Species
is: CHEBI:28477
is: HMDB02197
has only substance units: false

metaR r0829
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/4.1.1.37
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000000
modifier: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
product: MODEL1310110052#
is: SBO:0000185
fast: false

metaR PYDAMtr
reactant: MODEL1310110052#
product: MODEL1310110052#
name: pyridoxamine transport via diffusion
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110052#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_2d89cb8c_61ad_4d62_9218_bb945974daf1
is encoded by: hsa:5315
boundary condition: true
constant: false
type: Species
is: B4DNK4
initial concentration: NaN
name: PKM2
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR AMETtd
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
reactant: MODEL1310110052#
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000185
type: Reaction
name: diffusion of S-Adenosyl-L-methionine
reversible: true
fast: false

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_3e888b7f_e156_4de6_a85c_ab10dd1eb861
is: SBO:0000252
is: Q13733
name: ATP1A4
is encoded by: hsa:480
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110052#_c53afd5f_91d3_48c1_b120_6a92bee6c0e8
initial concentration: NaN
is: SBO:0000252
constant: false
name: ENPP3
boundary condition: true
type: Species
initial amount: NaN
is: Q308M7
is encoded by: hsa:5169
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_a81d7273_fa36_4795_ba77_6c9a010240d5
type: Species
constant: false
is encoded by: hsa:686
is: P43251
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: BTD
is: SBO:0000252
boundary condition: true

metaM 44mzym r
is: CHEBI:18364
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB01286
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
boundary condition: false
name: 14-demethyllanosterol

metaR GNDer
reversible: false
name: phosphogluconate dehydrogenase, endoplasmic reticulum
is: SBO:0000176
product: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
is described by: ECO:0000000

metaM HC02203 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial concentration: 1.0
has only substance units: false
constant: false
name: prostaglandin-a2
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:27820

metaM pmtcoa m
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:57379
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
boundary condition: false
is: C00154
is: HMDB01338
type: Species

metaM xoldiolone c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
initial concentration: 1.0
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
is: HMDB02197
type: Species
is: CHEBI:28477
initial amount: NaN
constant: false
has only substance units: false

metaR r1781
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110052#
type: Reaction
reversible: false
name: Y+LAT2 Utilized transport
product: MODEL1310110052#
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#

metaM oxa m
is: SBO:0000247
name: oxalate(2-)
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
type: Species
initial amount: NaN
boundary condition: false
is: HMDB02329
is: CHEBI:30623
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_7227bb28_c6a4_48cf_af70_df76401b46f7
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:80025
type: Species
is: Q6P1K9
initial concentration: NaN
name: PANK2
is: SBO:0000252
initial amount: NaN

metaR ATP1ter
name: ADP/ATP transporter, endoplasmic reticulum
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110052#
product: MODEL1310110052#
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_9f9c38c4_cd2c_4570_acee_756b2a0f7f31
is encoded by: hsa:5091
initial concentration: NaN
is: P11498
initial amount: NaN
is: SBO:0000252
type: Species
name: PC
boundary condition: true
has only substance units: false
constant: false

metaM dec24dicoa m
type: Species
is: HMDB01168
constant: false
name: 2,4-decadienoylcoa
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110052#_98bf6513_2427_4806_af3a_09899a9efc85
boundary condition: true
name: ACSS1
initial concentration: NaN
is: Q9NUB1
type: Species
constant: false
is encoded by: hsa:84532
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110052#_c5d8a159_afac_4956_a455_52343a2c38e8
is encoded by: hsa:10993
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
name: SDS
boundary condition: true
is: P20132

metaR AICARte
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110052#
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
fast: false
reactant: MODEL1310110052#
is described by: ECO:0000134
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_f5f10923_8672_42d9_9fc9_04b3e3d7a46f
name: _AI631997_1_m
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:AI631997

metaR RE3326M
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
reactant: MODEL1310110052#
name: RE3326
kinetic law: MODEL1310110052#
product: MODEL1310110052#
type: Reaction
fast: false
modifier: MODEL1310110052#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.4
reversible: true
is described by: ECO:0000000

metaM 10fthf c
is: HMDB00972
name: 10-Formyltetrahydrofolate
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: C00234
is: CHEBI:57454

http://identifiers.org/biomodels.db/MODEL1310110052#_8337bc23_fbe2_44d1_910c_3e562d0c6773
constant: false
boundary condition: true
is encoded by: hsa:9551
is: P56134
name: ATP5J2
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR NACHEX2ly
product: MODEL1310110052#
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
type: Reaction
reversible: false
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110052#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110052#

metaM hdcea c
boundary condition: false
name: Hexadecenoate (n-C16:1)
type: Species
has only substance units: false
constant: false
is: CHEBI:32372
initial amount: NaN
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: HMDB03229
is: SBO:0000247
initial concentration: 1.0

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

metaM HC02203 c
initial concentration: 1.0
name: prostaglandin-a2
type: Species
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:27820
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953

metaM 3hdcoa m
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
constant: false
type: Species
boundary condition: false
name: (S)-3-Hydroxydecanoyl-CoA
initial concentration: 1.0
notes: FORMULA: C31H50N7O18P3S CHARGE: -4

metaM sucsal m
constant: false
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
type: Species
has only substance units: false
boundary condition: false
is: HMDB01259
name: Succinic semialdehyde
is: CHEBI:57706
is: SBO:0000247
initial amount: NaN

metaM ksi deg29 l
is: HMDB00143
type: Species
initial amount: NaN
is: CHEBI:12936
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
has only substance units: false
constant: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 29
boundary condition: false
is: SBO:0000247

metaR BTNDe
reversible: false
name: biotinidase (biotin), extracellular
type: Reaction
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT
modifier: MODEL1310110052#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.1.12
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000176

metaR BHBt
name: (R)-3-Hydroxybutanoate transport via H+ symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110052#
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110052#
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_a0f0e928_98d6_4c5d_823c_f45f64576aa9
name: NT5C1B
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:93034
is: B3KUK6
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_c521bc02_948a_466a_b7be_29439e47bed3
constant: false
boundary condition: true
is: Q4W5N8
is encoded by: hsa:51166
name: AADAT
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR ECOAH9m
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
reversible: true
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000304
type: Reaction

metaM hexdicoa r
constant: false
name: hexadecanedioylcoa
is: SBO:0000247
is: C08260
is: HMDB00672
initial amount: NaN
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species

metaR EX pydx5p LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of pyridoxal 5-phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_5c05e122_23ac_455d_856a_5d17570d0065
boundary condition: true
constant: false
name: HKDC1
is encoded by: hsa:80201
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: B3KT70

metaR GAO1g
reversible: false
product: MODEL1310110052#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
name: Ganglioside O-acetylation
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
fast: false
modifier: MODEL1310110052#

metaR C226CPT2
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
is described by: ECO:0000000
reversible: false
name: C226 transport into the mitochondria
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
type: Reaction
product: MODEL1310110052#
modifier: MODEL1310110052#
fast: false

metaR PYNP2r
reversible: true
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
modifier: MODEL1310110052#
is described by: ECO:0000269
name: pyrimidine-nucleoside phosphorylase (uracil)
kinetic law: MODEL1310110052#
product: MODEL1310110052#
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.3
reactant: MODEL1310110052#

metaR ASNALANaEx
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
name: L-alanine/L-asparagine Na-dependent exchange (Asn-L in)
product: MODEL1310110052#
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
type: Reaction
fast: false

metaR RE1897C
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000176
is described by: ECO:0000000
fast: false
name: RE1897
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
reactant: MODEL1310110052#

metaM 3hdececrn c
name: 3-hydroxyhexadecenoylcarnitine
is: HMDB02014
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C23H43NO5 CHARGE: 0
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110052#_5c476b72_e04e_4c03_97ac_38b4b01073cd
is: P30084
initial concentration: NaN
boundary condition: true
has only substance units: false
name: ECHS1
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1892

http://identifiers.org/biomodels.db/MODEL1310110052#_36f4f7d2_2250_4c87_9545_168ca47e557c
name: ATP5H
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:10476
is: A0PJH2

metaM nadp x
is: CHEBI:58349
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: C00006
type: Species
name: Nicotinamide adenine dinucleotide phosphate
is: SBO:0000247
initial amount: NaN
is: HMDB00217

metaR O2t
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110052#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
name: o2 transport (diffusion)
is: SBO:0000185
reactant: MODEL1310110052#
product: MODEL1310110052#

metaR THFtm
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reactant: MODEL1310110052#
product: MODEL1310110052#
fast: false
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true

metaR r1633
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110052#
is: SBO:0000185
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reversible: true
fast: false
is described by: ECO:0000000

metaR ALCD2yf
kinetic law: MODEL1310110052#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES:NCD
reversible: false
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110052#
modifier: MODEL1310110052#
product: MODEL1310110052#
name: alcohol dehydrogenase (ethanol, NADP), forward reaction

metaR r0539
modifier: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.34
kinetic law: MODEL1310110052#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110052#
product: MODEL1310110052#
fast: false
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19

metaR C226CPT1
kinetic law: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
fast: false
modifier: MODEL1310110052#
name: carnitine C22:6 transferase
reversible: false
reactant: MODEL1310110052#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV

metaM dtdp m
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial concentration: 1.0
name: dTDP
is: C00363
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:58369
initial amount: NaN
type: Species
is: HMDB01274
constant: false

metaR FDH
is described by: ECO:0000304
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.6
type: Reaction
is: SBO:0000176
reversible: false
reactant: MODEL1310110052#
modifier: MODEL1310110052#
name: formate dehydrogenase
kinetic law: MODEL1310110052#
notes: GENE_ASSOCIATION: (10840.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.2.1.2 Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_36f1b4ec_4626_42f9_90dc_863e560463a6
is encoded by: hsa:10327
initial amount: NaN
is: SBO:0000252
name: AKR1A1
initial concentration: NaN
is: P14550
has only substance units: false
boundary condition: true
type: Species
constant: false

metaM dectricoa m
has only substance units: false
boundary condition: false
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
type: Species
name: 2,4,7-decatrienoylcoa

metaM dtdp n
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274
is: CHEBI:58369

metaM gln L c
initial concentration: 1.0
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00641
boundary condition: false
name: L-glutamine
is: CHEBI:18050
has only substance units: false
constant: false

metaR PI5P3K
reactant: MODEL1310110052#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
name: phosphatidylinositol-5-phosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.154
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.137
product: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.7.1.153
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
modifier: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#

metaR ADCim
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110052#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110052#
name: Acetoacetate decarboxylation (irreversible), mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
product: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_fa58de0a_f03c_4e79_931b_b51a9fa8dbcc
is encoded by: hsa:114134
initial concentration: NaN
initial amount: NaN
type: Species
is: Q96QE2
name: SLC2A13
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true

metaR EX decdicrn
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_091e2baf_256c_403d_b0e7_119528fb57f3
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3251
initial amount: NaN
constant: false
name: HPRT1
initial concentration: NaN
type: Species
boundary condition: true
is: P00492

http://identifiers.org/biomodels.db/MODEL1310110052#_fee1f8e8_e762_4bce_aa57_4a31f2206f2d
is: B3KUV7
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:5277
name: PIGA
has only substance units: false
is: SBO:0000252
constant: false

metaR r1632
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110052#
modifier: MODEL1310110052#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110052#

metaR FACOAL184
product: MODEL1310110052#
kinetic law: MODEL1310110052#
is: SBO:0000176
fast: false
reversible: true
modifier: MODEL1310110052#
is described by: ECO:0000000
name: fatty-acid--CoA ligase
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110052#
is version of: http://identifiers.org/ec-code/6.2.1.3

metaM gtp c
type: Species
initial concentration: 1.0
is: HMDB01273
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:37565
name: GTP
initial amount: NaN
is: C00044
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044

http://identifiers.org/biomodels.db/MODEL1310110052#_d075730b_e0de_4203_a4e3_ad7df6dfcc72
has only substance units: false
constant: false
is encoded by: hsa:55568
name: GALNT10
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_b2c30e83_5008_4e11_9f1d_8556ded7b3d8
has only substance units: false
is: P80404
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:18
initial amount: NaN
name: ABAT
type: Species

metaR PCm
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000269
name: pyruvate carboxylase
type: Reaction
is version of: http://identifiers.org/ec-code/6.4.1.1
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
product: MODEL1310110052#
fast: false
is: SBO:0000176
modifier: MODEL1310110052#
reversible: false

metaR 4HBZFm
kinetic law: MODEL1310110052#
name: 4-hydroxybenzoate formation
is: SBO:0000176
reactant: MODEL1310110052#
is described by: ECO:0000000
reversible: false
product: MODEL1310110052#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
fast: false

metaR CYTK9n
kinetic law: MODEL1310110052#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110052#
reactant: MODEL1310110052#
product: MODEL1310110052#
name: cytidylate kinase (CMP,dCTP),nuclear

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_72a0331e_2365_4dbf_86c5_4130cecafd61
constant: false
is: O75908
type: Species
initial amount: NaN
is encoded by: hsa:8435
initial concentration: NaN
name: SOAT2
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR SUBERCACT
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberyl carnitine into cytosol
type: Reaction

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaR r1631
is described by: ECO:0000000
product: MODEL1310110052#
reversible: true
kinetic law: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM c4crn m
initial amount: NaN
has only substance units: false
notes: FORMULA: C11H21NO4 CHARGE: 0
is: http://identifiers.org/pubchem.compound/213144
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
is: C02862
constant: false
name: butyryl carnitine
is: HMDB02013

metaM ocdececrn m
is: HMDB06351
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0
name: 11-octadecenoyl carnitine
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110052#_387f2e18_d095_4f05_a0c2_675656058565
is encoded by: hsa:4129
name: MAOB
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P27338
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110052#_29a6830d_9614_4cae_ba07_5fb1858c8389
type: Species
name: SLC7A2
has only substance units: false
is: P52569
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6542
constant: false

metaR FAOXC181C161x
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C18:1-->C16:1)x
type: Reaction

metaM amet m
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
has only substance units: false
is: C00019
is: HMDB01185
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
name: S-Adenosyl-L-methionine
is: CHEBI:15414
initial concentration: 1.0
boundary condition: false

metaM gln L e
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: CHEBI:18050
has only substance units: false
is: SBO:0000247
name: L-glutamine
is: HMDB00641
type: Species

metaR ASNSERNaEx
is: SBO:0000185
name: L-serine/L-asparagine Na-dependent exchange (Asn-L in)
type: Reaction
fast: false
kinetic law: MODEL1310110052#
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110052#
reversible: false
reactant: MODEL1310110052#
is described by: ECO:0000269

metaR ALATHRNaEx
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110052#
product: MODEL1310110052#
modifier: MODEL1310110052#
fast: false
reactant: MODEL1310110052#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-alanine/L-threonine Na-dependent exchange (Ala-L in)

metaR ADEt
is: SBO:0000185
fast: false
modifier: MODEL1310110052#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
kinetic law: MODEL1310110052#
product: MODEL1310110052#
name: adenine reversible transport, cytosol
is described by: ECO:0000269
reactant: MODEL1310110052#

metaR r1630
reactant: MODEL1310110052#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110052#
kinetic law: MODEL1310110052#

metaM dmnoncoa c
is: HMDB11604
boundary condition: false
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
name: 4,8 dimethylnonanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110052#_5476b998_2d2e_4259_b00e_10863141a9f3
initial concentration: NaN
initial amount: NaN
is: P34059
has only substance units: false
constant: false
is: SBO:0000252
name: GALNS
type: Species
is encoded by: hsa:2588
boundary condition: true

metaR S6T11g
modifier: MODEL1310110052#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110052#
reversible: false
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#

metaR EX bglc LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for beta glucans
type: Reaction

metaM xol7ah3 c
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,26-triol
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
is: CHEBI:28540
is: HMDB12455
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110052#_3c1bea70_94ad_4ad3_80d3_cabe89e90ed1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8288
is: SBO:0000252
has only substance units: false
name: EPX
is: P11678
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110052#_bdfe91f5_da0c_4eb2_8139_be543c50f3d7
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:113
has only substance units: false
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: P51828
name: ADCY7

metaR r1636
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110052#
product: MODEL1310110052#
modifier: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0683
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110052#
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
reactant: MODEL1310110052#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110052#
type: Reaction
is: SBO:0000176
reversible: false

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaM aacoa c
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
boundary condition: false
is: HMDB01484
initial amount: NaN
type: Species
is: C00332
is: SBO:0000247
initial concentration: 1.0
name: Acetoacetyl-CoA
has only substance units: false
is: CHEBI:57286
constant: false

metaR MACACI
kinetic law: MODEL1310110052#
type: Reaction
reactant: MODEL1310110052#
name: maleylacetoacetate isomerase
is described by: ECO:0000269
product: MODEL1310110052#
reversible: false
fast: false
is: SBO:0000176
modifier: MODEL1310110052#
is version of: http://identifiers.org/ec-code/2.5.1.18
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD

metaR TAUBETAtc
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by beta transport system
type: Reaction

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

metaM ksi pre22 g
is: HMDB00175
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 22
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:58053
constant: false
has only substance units: false
is: C00130
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
initial concentration: 1.0

metaM 1p3h5c m
initial concentration: 1.0
initial amount: NaN
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
has only substance units: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:6151
is: HMDB01369
type: Species

metaR R group phosphotase 1
is: SBO:0000176
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110052#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
name: R group phosphotase 1
kinetic law: MODEL1310110052#
type: Reaction
product: MODEL1310110052#

metaR MI14P4P
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
name: inositol-1,4-bisphosphate 4-phosphatase
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
product: MODEL1310110052#
is: SBO:0000176
is described by: ECO:0000000

metaR LNLNCGCPT2
product: MODEL1310110052#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
name: carnitine transferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110052#
fast: false
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
is described by: ECO:0000269
reversible: false

metaR r1637
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110052#
product: MODEL1310110052#
reversible: true
kinetic law: MODEL1310110052#
is described by: ECO:0000000
modifier: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_0d4fe60c_c4b2_42a1_8602_213e7adc0037
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
name: ITPKB
is: SBO:0000252
is: P27987
initial concentration: NaN
constant: false
is encoded by: hsa:3707

metaM dudp n
has only substance units: false
type: Species
constant: false
boundary condition: false
is: CHEBI:60471
is: SBO:0000247
is: HMDB01000
initial amount: NaN
name: dUDP(3-)
initial concentration: 1.0
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346

metaR DIGALSIDEtl
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
type: Reaction
fast: false
product: MODEL1310110052#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110052#
name: digalside hs intracellular transport

metaR r0830
is version of: http://identifiers.org/ec-code/3.5.4.16
type: Reaction
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
product: MODEL1310110052#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
modifier: MODEL1310110052#
reactant: MODEL1310110052#
fast: false
kinetic law: MODEL1310110052#

metaR UDPtl
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
product: MODEL1310110052#
type: Reaction
is described by: ECO:0000000
name: udp intracellular transport
fast: false
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#

http://identifiers.org/biomodels.db/MODEL1310110052#_d710ce2d_03ab_4570_b011_a6558e6c1ca1
name: NDUFA5
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:4698
is: Q16718
type: Species
initial concentration: NaN

metaM ksi deg14 l
is: SBO:0000247
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
name: keratan sulfate I, degradation product 14
is: HMDB00143
initial concentration: 1.0
constant: false
is: CHEBI:12936
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110052#
reactant: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaM lnlncacoa m
constant: false
name: alpha-Linolenoyl-CoA
initial amount: NaN
type: Species
is: CHEBI:51985
is: SBO:0000247
has only substance units: false
is: HMDB06290
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
initial concentration: 1.0
boundary condition: false

metaM dsT antigen g
initial concentration: 1.0
has only substance units: false
name: disialyl-T antigen
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C36H56N3O26X CHARGE: -2
is: CHEBI:16497
constant: false
is: HMDB01440
initial amount: NaN

metaR FATP3t
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reactant: MODEL1310110052#
modifier: MODEL1310110052#
kinetic law: MODEL1310110052#
product: MODEL1310110052#
is described by: ECO:0000269
fast: false
name: fatty acid electroneutral transport
is: SBO:0000185

metaM 3hdcoa c
boundary condition: false
is: HMDB00651
type: Species
constant: false
name: (S)-3-Hydroxydecanoyl-CoA
initial amount: NaN
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaR CHATn
fast: false
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.6
kinetic law: MODEL1310110052#
name: Choline O-acetyltransferase
type: Reaction
product: MODEL1310110052#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110052#
reactant: MODEL1310110052#

metaR IDOURte
is described by: ECO:0000134
name: L-iduronate transport, extracellular
reactant: MODEL1310110052#
kinetic law: MODEL1310110052#
fast: false
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110052#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR C80CPT1
kinetic law: MODEL1310110052#
product: MODEL1310110052#
reactant: MODEL1310110052#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of octanoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110052#_745572a5_b8db_4c53_9686_650efdb095f2
has only substance units: false
is encoded by: hsa:23530
name: NNT
initial amount: NaN
is: Q13423
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
boundary condition: true

metaR MMCDm
reversible: false
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES:JLR mitochondrial isoform - NCD
fast: false
modifier: MODEL1310110052#
type: Reaction
kinetic law: MODEL1310110052#
name: Methylmalonyl-CoA decarboxylase, mitochondrial
is version of: http://identifiers.org/ec-code/4.1.1.9
reactant: MODEL1310110052#
is: SBO:0000176
product: MODEL1310110052#